Si-Chong Ren, Xiangqi Chen, Hui Gong, Han Wang, Chuan Wu, Pei-Heng Li, Xiao-Feng Chen, Jia-Hua Qu, Xiaoqiang Tang
Aging is a key risk factor for angiogenic dysfunction and cardiovascular diseases, including heart failure, hypertension, atherosclerosis, diabetes, and stroke. Members of the NAD+ -dependent class III histone deacetylase family, sirtuins, are conserved regulators of aging and cardiovascular and cerebrovascular diseases. The sirtuin SIRT6 is predominantly located in the nucleus and shows deacetylase activity for acetylated histone 3 lysine 56 and lysine 9 as well as for some non-histone proteins. Over the past decade, experimental analyses in rodents and non-human primates have demonstrated the critical role of SIRT6 in extending lifespan...
July 11, 2022: Aging and Disease