Yunhui Du, Yanru Duan, Jianli Zhao, Caihong Liu, Zhen Zhang, John Zhang, Zhijun Meng, Xiaoliang Wang, Wayne Bond Lau, Dina Xie, Bernard L Lopez, Theodore A Christopher, Erhe Gao, Walter W Koch, Huirong Liu, Demin Liu, Xin-Liang Ma, Guoqiang Gu, Yajing Wang
BACKGROUND: APN (adiponectin) and APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) are potent vasculoprotective molecules, and their deficiency (eg, hypoadiponectinemia) contributes to diabetic vascular complications. However, the molecular mechanisms that govern their vasculoprotective genes as well as their alteration by diabetes remain unknown. METHODS: Diabetic medium-cultured rat aortic endothelial cells, mouse aortic endothelial cells from high-fat-diet animals, and diabetic human aortic endothelial cells were used for molecular/cellular investigations...
October 5, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology