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https://www.readbyqxmd.com/read/28641056/the-odd-couple-using-biomedical-and-intersectional-approaches-to-address-health-inequities
#1
Olena Hankivsky, Lesley Doyal, Gillian Einstein, Ursula Kelly, Janet Shim, Lynn Weber, Robin Repta
BACKGROUND: Better understanding and addressing health inequities is a growing global priority. OBJECTIVE: In this paper, we contribute to the literature examining complex relationships between biological and social dimensions in the field of health inequalities. Specifically, we explore the potential of intersectionality to advance current approaches to socio-biological entwinements. DESIGN: We provide a brief overview of current approaches to combining both biological and social factors in a single study, and then investigate the contributions of an intersectional framework to such work...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28641018/three-dimensional-imaging-of-transparent-tissues-via-metal-nanoparticle-labeling
#2
Abdullah Muhammad Syed, Shrey Sindhwani, Stefan Wilhelm, Benjamin R Kingston, Dennis S W Lee, Jennifer L Gommerman, Warren C W Chan
Chemical probes are key components of the bioimaging toolbox as they label biomolecules in cells and tissues. The new challenge in bioimaging is to design chemical probes for 3-Dimensional (3D) tissue imaging. Here, we discovered that the scattering of metal nanoparticles can provide imaging contrast in intact tissues in 3D. The nanoparticles can act as a template for chemically growing a metal layer to further enhance the scattering signal. The use of chemically-grown nanoparticles in whole tissues can amplify the scattering to produce a 1...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28641005/electron-crystallography-reveals-atomic-structures-of-metal-organic-nanoplates-with-m12-%C3%AE-3-o-8-%C3%AE-3-oh-8-%C3%AE-2-oh-6-m-zr-hf-secondary-building-units
#3
Ruihan Dai, Fei Peng, Pengfei Ji, Kuangda Lu, Cheng Wang, Junliang Sun, Wenbin Lin
Nanoscale metal-organic frameworks (nMOFs) have shown tremendous potential in cancer therapy and biomedical imaging. However, their small dimensions present a significant challenge in structure determination by single-crystal X-ray crystallography. We report here the structural determination of nMOFs by rotation electron diffraction (RED). Two isostructural Zr- and Hf-based nMOFs with linear biphenyldicarboxylate (BPDC) or bipyridinedicarboxylate (BPYDC) linkers are stable under intense electron beams to allow the collection of high-quality RED data, which reveal a MOF structure with M12(μ3-O)8(μ3-OH)8(μ2-OH)6 (M = Zr, Hf) secondary building units (SBUs)...
June 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28640986/antimonene-quantum-dots-synthesis-and-application-as-near-infrared-photothermal-agents-for-effective-cancer-therapy
#4
Wei Tao, Xiaoyuan Ji, Xiaoding Xu, Mohammad Ariful Islam, Zhongjun Li, Si Chen, Phei Er Saw, Han Zhang, Zameer Bharwani, Zilei Guo, Jinjun Shi, Omid Farokhzad
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28640594/biomedical-diagnostics-enabled-by-integrated-organic-and-printed-electronics
#5
Termeh Ahmadraji, Laura Gonzalez-Macia, Tapio Ritvonen, Andreas Willert, Saara Tuurala, Satu Ylimaula, David Donaghy, Mika Suhonen, Dave Smart, Vitaly Efremov, Aoife Morrin, Reinhard R Baumann, Munira Raja, Antti Kemppainen, Anthony J Killard
Organic and printed electronics integration has the potential to revolutionise many technologies, including biomedical diag-nostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide, and total cholesterol. The single-use device employed printed electrochemical sen-sors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon ICs via pick and place, or using organic electronic circuits...
June 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28637351/tuning-surface-chemistry-of-polyetheretherketone-by-gold-coating-and-plasma-treatment
#6
Zdeňka Novotná, Silvie Rimpelová, Petr Juřík, Martin Veselý, Zdeňka Kolská, Tomáš Hubáček, Jakub Borovec, Václav Švorčík
Polyetheretherketone (PEEK) has good chemical and biomechanical properties that are excellent for biomedical applications. However, PEEK exhibits hydrophobic and other surface characteristics which cause limited cell adhesion. We have investigated the potential of Ar plasma treatment for the formation of a nanostructured PEEK surface in order to enhance cell adhesion. The specific aim of this study was to reveal the effect of the interface of plasma-treated and gold-coated PEEK matrices on adhesion and spreading of mouse embryonic fibroblasts...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28636063/solving-interoperability-in-translational-health-perspectives-of-students-from-the-international-partnership-in-health-informatics-education-iphie-2016-master-class
#7
Anne M Turner, Julio C Facelli, Monique Jaspers, Thomas Wetter, Daniel Pfeifer, Laël Cranmer Gatewood, Terry Adam, Yu-Chuan Li, Ming-Chin Lin, R Scott Evans, Anna Beukenhorst, Hugo Johan Theodoore van Mens, Esmee Tensen, Christian Bock, Laura Fendrich, Peter Seitz, Julian Suleder, Ranyah Aldelkhyyel, Kent Bridgeman, Zhen Hu, Aaron Sattler, Shin-Yi Guo, Islam Md Mohaimenul Mohaimenul, Dina Nur Anggraini Ningrum, Hsin-Ru Tung, Jiantano Bian, Joseph M Plasek, Casey Rommel, Juandalyn Burke, Harkirat Sohih
BACKGROUND: In the summer of 2016 an international group of biomedical and health informatics faculty and graduate students gathered for the 16th meeting of the International Partnership in Health Informatics Education (IPHIE) masterclass at the University of Utah campus in Salt Lake City, Utah. This international biomedical and health informatics workshop was created to share knowledge and explore issues in biomedical health informatics (BHI). OBJECTIVE: The goal of this paper is to summarize the discussions of biomedical and health informatics graduate students who were asked to define interoperability, and make critical observations to gather insight on how to improve biomedical education...
June 20, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28635300/pyridine-dinucleotides-from-molecules-to-man
#8
Joshua P Fessel, William M Oldham
SIGNIFICANCE: Pyridine dinucleotides, NAD and NADP, were discovered over 100 years ago as necessary cofactors for fermentation in yeast extracts. Since that time, these molecules have been recognized as fundamental players in a variety of cellular processes, including energy metabolism, redox homeostasis, cellular signaling, and gene transcription, among many others. Given their critical role as mediators of cellular responses to metabolic perturbations, it is unsurprising that dysregulation of NAD and NADP metabolism has been associated with the pathobiology of many chronic human diseases...
June 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28635132/the-fabrication-of-iron-oxide-nanoparticle-nanofiber-composites-by-electrospinning-and-their-applications-in-tissue-engineering
#9
REVIEW
Chris J Mortimer, Chris J Wright
This paper reviews the use of iron oxide nanoparticle-nanofiber composites in tissue engineering with a focus on the electrospinning technique. Electrospinning is an established method of scaffold fabrication offering a number of key advantages which include its facile nature, with electrospun materials offering a high surface area to volume ratio, potential for the release of drugs and antimicrobials, controllable fiber diameters and high porosity and permeability. A number of different techniques for the preparation of iron oxide nanoparticles including their functionalization are discussed along with their applications in the biomedical field...
June 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28635130/prothrombin-complex-concentrate-for-emergent-reversal-of-warfarin-an-international-survey-of-hospital-protocols
#10
J Gorlin, S Kinney, M K Fung, A Tinmouth
For emergent warfarin reversal, four-factor prothrombin complex concentrates (4FPCCs) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC, 25% use PCC+ plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed.
June 21, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28634603/high-resolution-and-multi-range-particle-separation-by-microscopic-vibration-in-an-optofluidic-chip
#11
Y Z Shi, S Xiong, L K Chin, Y Yang, J B Zhang, W Ser, J H Wu, T N Chen, Z C Yang, Y L Hao, B Liedberg, P H Yap, Y Zhang, A Q Liu
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created with combined optical and fluidic constraints. It is the first demonstration of separating single nanoparticles with diameters ranging from 60 to 100 nm with a resolution of 10 nm. Nanoparticles vibrate with an amplitude of 3-7 μm in the loosely overdamped potential wells in the microchannel...
June 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28634590/the-immune-epitope-database-how-data-are-entered-and-retrieved
#12
REVIEW
Ward Fleri, Kerrie Vaughan, Nima Salimi, Randi Vita, Bjoern Peters, Alessandro Sette
Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epitope and assay information related to infectious diseases, autoimmune diseases, allergic diseases, and transplant/alloantigens for humans, nonhuman primates, mice, and any other species studied. It contains T cell, B cell, MHC binding, and MHC ligand elution experiments...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28634344/omniga-optimized-omnivariate-decision-trees-for-generalizable-classification-models
#13
Arturo Magana-Mora, Vladimir B Bajic
Classification problems from different domains vary in complexity, size, and imbalance of the number of samples from different classes. Although several classification models have been proposed, selecting the right model and parameters for a given classification task to achieve good performance is not trivial. Therefore, there is a constant interest in developing novel robust and efficient models suitable for a great variety of data. Here, we propose OmniGA, a framework for the optimization of omnivariate decision trees based on a parallel genetic algorithm, coupled with deep learning structure and ensemble learning methods...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634117/to-assess-the-effects-of-parathyroidectomy-tptx-versus-tptx-at-for-secondary-hyperparathyroidism-in-chronic-renal-failure-a-meta-analysis
#14
REVIEW
Nian-Cun Qiu, Si-Luo Zha, Miao-E Liu, Zhi-Peng Du, Yi-Fan Wang, Qiang Wang, Qi Chen, Ying Jiang, Cheng-Xiang Shan, Ming Qiu
BACKGROUND: Secondary Hyperparathyroidism (SHPT) requiring parathyroidectomy (PTX) occurs more commonly in patients with progressive chronic kidney disease and in those on long-term lithium therapy. Successful PTX often results in a dramatic drop of parathyroid hormone level, relieves the patient from clinical symptoms, and reduces mortality. However, there is an ongoing debate on the optimal surgical treatment of SHPT. Currently, no clinical guidelines or trials have definitely answered the question of whether Total Parathyroidectomy (TPTX) is superior or equal to Total Parathyroidectomy with Autotransplantation (TPTX + AT)...
June 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28634022/goals-and-objectives-of-the-italian-network-for-tumor-biotherapy-nibit
#15
Vincenzo Russo, Alberto Amadori, Marco Bregni, Luana Calabrò, Mario Paolo Colombo, Massimo Di Nicola, Pier Francesco Ferrucci, Enrico Proietti, Michele Maio, Matteo Bellone
The explosion in the immuno-oncology field, exemplified by the clinical implementation of immune checkpoint inhibitor blockade and other immunotherapeutic strategies was quickly recognized by the Italian biomedical community, thanks to the networking activities of the Italian Network for Tumor Biotherapy (NIBIT), which has been active since 2004 in the diffusion of new scientific and clinical findings in the fields of tumor immunology and immunotherapy. Numerous activities of NIBIT have also helped to overcome the hurdles associated with the clinical implementation of cancer immune-biotherapeutic strategies at the national and international levels...
June 16, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28633953/reversal-learning-and-resurgence-of-operant-behavior-in-zebrafish-danio-rerio
#16
Toshikazu Kuroda, Yuto Mizutani, Carlos R X Cançado, Christopher A Podlesnik
Zebrafish are used extensively as vertebrate animal models in biomedical research for having such features as a fully sequenced genome and transparent embryo. Yet, operant-conditioning studies with this species are scarce. The present study investigated reversal learning and resurgence of operant behavior in zebrafish. A target response (approaching a sensor) was reinforced in Phase 1. In Phase 2, the target response was extinguished while reinforcing an alternative response (approaching a different sensor)...
June 17, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28633930/phospholipase-a2-in-the-venom-of-three-cottonmouth-snake-species
#17
Ying Jia, Boris Ermolinsky, Aryana Garza, Daniele Provenzano
Two phospholipase A2s (PLA2s), Asp49 (D49) and Lys49 (K49), were purified by one-step reverse-phase high performance liquid chromatography (RP-HPLC) from the venom of each of the three subspecies of cottonmouth snake, Western cottonmouth (Agkistrodon piscivorus leucostoma; Apl), Eastern cottonmouth (Agkistrodon piscivorus piscivorus; App) and Florida cottonmouth (Agkistrodon piscivorus conanti; Apc). Venom protein profiles and PLA2s elution pattern of the three cottonmouth snakes were remarkably similar displaying four similar sharp and two wide peaks; in all cases K49 PLA2 eluted first followed by D49 PLA2...
June 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28633813/multi-stimuli-responsive-smart-chitosan-based-microcapsules-for-targeted-drug-delivery-and-triggered-drug-release
#18
Xuejun Cui, Xinyu Guan, Shuangling Zhong, Jie Chen, Houjuan Zhu, Zhanfeng Li, Fengzhi Xu, Peng Chen, Hongyan Wang
In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633659/computing-patient-data-in-the-cloud-practical-and-legal-considerations-for-genetics-and-genomics-research-in-europe-and-internationally
#19
Fruzsina Molnár-Gábor, Rupert Lueck, Sergei Yakneen, Jan O Korbel
Biomedical research is becoming increasingly large-scale and international. Cloud computing enables the comprehensive integration of genomic and clinical data, and the global sharing and collaborative processing of these data within a flexibly scalable infrastructure. Clouds offer novel research opportunities in genomics, as they facilitate cohort studies to be carried out at unprecedented scale, and they enable computer processing with superior pace and throughput, allowing researchers to address questions that could not be addressed by studies using limited cohorts...
June 20, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28633401/biomedical-text-mining-for-research-rigor-and-integrity-tasks-challenges-directions
#20
Halil Kilicoglu
An estimated quarter of a trillion US dollars is invested in the biomedical research enterprise annually. There is growing alarm that a significant portion of this investment is wasted because of problems in reproducibility of research findings and in the rigor and integrity of research conduct and reporting. Recent years have seen a flurry of activities focusing on standardization and guideline development to enhance the reproducibility and rigor of biomedical research. Research activity is primarily communicated via textual artifacts, ranging from grant applications to journal publications...
June 13, 2017: Briefings in Bioinformatics
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