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https://www.readbyqxmd.com/read/28743033/analysis-of-the-genetic-structure-of-the-malay-population-ancestry-informative-marker-snps-in-the-malay-of-peninsular-malaysia
#1
Padillah Yahya, Sarina Sulong, Azian Harun, Hatin Wan Isa, Nur-Shafawati Ab Rajab, Pongsakorn Wangkumhang, Alisa Wilantho, Chumpol Ngamphiw, Sissades Tongsima, Zilfalil Alwi
Malay, the main ethnic group in Peninsular Malaysia, is represented by various sub-ethnic groups such as Melayu Banjar, Melayu Bugis, Melayu Champa, Melayu Java, Melayu Kedah Melayu Kelantan, Melayu Minang and Melayu Patani. Using data retrieved from the MyHVP (Malaysian Human Variome Project) database, a total of 135 individuals from these sub-ethnic groups were profiled using the Affymetrix GeneChip Mapping Xba 50-K single nucleotide polymorphism (SNP) array to identify SNPs that were ancestry-informative markers (AIMs) for Malays of Peninsular Malaysia...
July 14, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28742970/interaction-behaviors-of-fibrinopeptide-a-and-graphene-with-different-functional-groups-a-molecular-dynamics-simulation-approach
#2
Menghao Wang, Qun Wang, Xiong Lu, Ke Feng Wang, Liming Fang, Fuzeng Ren, Guoming Lu, Hongping Zhang
Graphene as a 2-dimentional material has been widely used in the field of biomedical applications. In this study, molecular dynamics simulations are carried out on the fibrinopeptide-A and graphene surfaces with N and O modifications. A new set of parameters for CHARMM force field are developed to describe the behaviors of the surfaces. Our results indicate that the existence of most oxygen and nitrogen groups may enhance the interaction between the surfaces and the peptide, whereas the substitutional nitrogen on the graphene surface does not make a big difference...
July 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28742329/selecting-dna-encoded-chemical-library-against-non-immobilized-proteins-using-a-ligate-crosslink-purify-strategy
#3
Bingbing Shi, Yuqing Deng, Peng Zhao, Xiaoyu Li
DNA-encoded chemical library (DEL) has recently emerged and become an important technology platform in biomedical research and drug discovery. DELs containing large numbers of compounds can be prepared and selected against biological targets to discover novel ligands and inhibitors. In practice, DELs are usually selected against purified and immobilized proteins using the typical "bind-wash-elute" protocol; however, selection methods compatible with non-immobilized proteins would be able to greatly expand the target scope of DELs beyond purified proteins to more complex and biologically relevant targets...
July 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28742047/optimal-broadband-noise-matching-to-inductive-sensors-application-to-magnetic-particle-imaging
#4
Bo Zheng, Patrick W Goodwill, Neerav Dixit, Di Xiao, Wencong Zhang, Beliz Gunel, Kuan Lu, Greig C Scott, Steven M Conolly
Inductive sensor-based measurement techniques are useful for a wide range of biomedical applications. However, optimizing the noise performance of these sensors is challenging at broadband frequencies, owing to the frequency-dependent reactance of the sensor. In this work, we describe the fundamental limits of noise performance and bandwidth for these sensors in combination with a low-noise amplifier. We also present three equivalent methods of noise matching to inductive sensors using transformer-like network topologies...
July 20, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28741862/in-vivo-comparison-of-jellyfish-and-bovine-collagen-sponges-as-prototype-medical-devices
#5
Jonathan P Widdowson, Alex J Picton, Valerie Vince, Chris J Wright, Andrew Mearns-Spragg
Jellyfish have emerged as a source of next generation collagen that is an attractive alternative to existing sources, such as bovine and porcine, due to a plentiful supply and providing a safer source through lack of bovine spongiform encephalopathy (BSE) transmission risk and potential viral vectors, both of which could be transmitted to humans. Here we compare collagen implantable sponges derived for the first time from the Rhizostoma pulmo jellyfish. A further novelty for the research was that there was a comparison for sponges that were either uncrosslinked or crosslinked using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), and an assessment on how this affected resorption, as well as their biocompatibility compared to bovine type I collagen sponges...
July 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28741708/hollow-mxene-spheres-and-3d-macroporous-mxene-frameworks-for-na-ion-storage
#6
Meng-Qiang Zhao, Xiuqiang Xie, Chang E Ren, Taron Makaryan, Babak Anasori, Guoxiu Wang, Yury Gogotsi
2D transition metal carbides and nitrides, named MXenes, are attracting increasing attentions and showing competitive performance in energy storage devices including electrochemical capacitors, lithium- and sodium-ion batteries, and lithium-sulfur batteries. However, similar to other 2D materials, MXene nanosheets are inclined to stack together, limiting the device performance. In order to fully utilize MXenes' electrochemical energy storage capability, here, processing of 2D MXene flakes into hollow spheres and 3D architectures via a template method is reported...
July 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28741643/self-reference-plasmonic-sensors-based-on-double-fano-resonances
#7
Yujia Wang, Chengwei Sun, Hongyun Li, Qihuang Gong, Jianjun Chen
High-sensitivity plasmonic refractive index sensors show great applications in the areas of biomedical diagnostics, healthcare, food safety, environmental monitoring, homeland security, and chemical reactions. However, the unstable and complicated environments considerably limit their practical applications. By employing the independent double Fano resonances in a simple metallic grating, we experimentally demonstrate a self-reference plasmonic sensor, which significantly reduces the error contributions of the light intensity fluctuations in the long-distance propagation and local temperature variations at the metallic grating, and the detection accuracy is guaranteed...
July 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28741141/detonation-nanodiamonds-are-promising-nontoxic-delivery-system-for-urothelial-cells
#8
Daša Zupančič, Mateja Erdani Kreft, Maja Grdadolnik, Dimitar Mitev, Aleš Iglič, Peter Veranič
Detonation nanodiamonds (DNDs) are carbon-based nanomaterials that are among the most promising nanoparticles available for biomedical applications so far. This is due to their biocompatibility, which could be contributed to their inert core and conformable surface nature. However, DNDs cytotoxicity for urothelial cells and the routes of their internalization remains an open question in the aspect of nanodiamond surface. We therefore analyzed four types of DNDs for cytotoxicity and internalization with normal urothelial cells and two types of cancer urothelial cell lines in vitro...
July 24, 2017: Protoplasma
https://www.readbyqxmd.com/read/28740689/types-of-biological-variables
#9
EDITORIAL
Shreemathi S Mayya, Ashma D Monteiro, Sachit Ganapathy
Identification and description of variables used in any study is a necessary component in biomedical research. Statistical analyses rely on the type of variables that are involved in the study. In this short article, we introduce the different types of biological variables. A researcher has to be familiar with the type of variable he/she is dealing with in his/her research to decide about appropriate graphs/diagrams, summary measures and statistical analysis.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740550/boosting-the-peroxidase-like-activity-of-nanostructured-nickel-by-inducing-its-3-oxidation-state-in-lanio3-perovskite-and-its-application-for-biomedical-assays
#10
Xiaoyu Wang, Wen Cao, Li Qin, Tingsheng Lin, Wei Chen, Shichao Lin, Jia Yao, Xiaozhi Zhao, Min Zhou, Cheng Hang, Hui Wei
Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with peroxidase mimicking activities because of their promising applications in biosensing, bioimaging, biomedicine, etc. Till now, lots of functional nanomaterials have been used to mimic peroxidase...
2017: Theranostics
https://www.readbyqxmd.com/read/28739502/development-of-biomedical-5-fluorouracil-nanoplatforms-for-colon-cancer-chemotherapy-influence-of-process-and-formulation-parameters
#11
Elena Pretel, José L Arias, Laura Cabeza, Consolación Melguizo, José C Prados, Mireia Mallandrich, Joaquim Suñer, Beatriz Clares
In the present investigation solvent displacement or nanoprecipitation, and double emulsion/solvent evaporation methods were utilized to optimize poly(D,L-lactide-co-glycolide) nanoparticles for the vehiculization of the 5-fluorouracil. Formulation components from both the aqueous and organic phases, as well as, operating conditions were varied. Particles were characterized in terms of particle size and morphology, electrical properties, rheology, drug loading, stability, and drug release. Furthermore, in vitro cytotoxicity on human colon cells and different colon carcinoma cells was evaluated...
July 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28739161/automated-face-recognition-of-rhesus-macaques
#12
Claire L Witham
BACKGROUND: Rhesus macaques are widely used in biomedical research. Automated behavior monitoring can be useful in various studies (including neuroscience), as well as having applications to animal welfare but current technology lags behind that developed for other species. One difficulty facing developers is the reliable identification of individual macaques within a group especially as pair- and group-housing of macaques becomes standard. Current published methods require either implantation or wearing of a tracking device...
July 21, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28738774/advanced-methods-for-analysis-of-testosterone
#13
Livia Alexandra Gugoasa, Raluca Ioana Stefan-van Staden
Testosterone is the principal endogenous androgenic-anabolic steroid in humans. The levels of testosterone in the human body are correlated with many hormonal disorders (hypogonadism, impotence, etc) mostly in men, and with many types of diseases such as: prostate cancer, metabolic syndrome, obesity, cardiovascular diseases and so on. Testosterone is extensively used among sportsmen willing to increase strength, aggressiveness, and recovery; making it the most commonly reported substance in steroid abuse. Fast, easy and cheap methods for the evaluation of testosterone are extremely needed in clinics and hospitals...
July 24, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28738657/a-new-strategy-for-fabrication-of-water-dispersible-and-biodegradable-fluorescent-organic-nanoparticles-with-aie-and-esipt-characteristics-and-their-utilization-for-bioimaging
#14
Dazhuang Xu, Meiying Liu, Hui Zou, Jianwen Tian, Hongye Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Fluorescence probes play a crucial role in optical imaging for visualization of complex biological processes. As compared with conventional organic fluorogens, the probes with aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics show significant advantages in high quantum yield at concentrated and aggregated state, large Stokes shift and low cytotoxicity. However, the synthesis of AIE-active fluorescent probes through the ESIPT mechanism has received only very limited attention...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738605/rapid-one-pot-synthesis-of-mmta-protected-fluorescent-gold-nanoclusters-for-selective-and-sensitive-detection-of-ferric-ion
#15
Jingjing Jiang, Pengfei Gao, Yan Zhang, Guomei Zhang, Ying Zhou, Chuan Dong, Shaomin Shuang
Herein, we demonstrate a straightforward synthesis of fluorescent gold nanoclusters (AuNCs), employing 2-Mercapto-4-methyl-5-thiazoleacetic acid (MMTA) as a reducing and protecting agent by a rapid one-pot synthesis method with a short time of 20min. The as-synthesized MMTA-AuNCs exhibited bright blue emission with a strong peak centered at 430nm and the quantum yield (QY) was evaluated to be 4.0%. Based on the fluorescence quenching mechanism of a surface chelating reaction between MMTA and ferric ion (Fe(3+)), the MMTA-AuNCs were exploited as a fluorescence sensor for sensitive and selective detection of Fe(3+)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738477/-meta-analysis-on-influence-of-psychological-nursing-on-quality-of-life-of-aids-patients
#16
Q Liu, R Zhao, Q Wu, G H Zhuang
Objective: To evaluate the effect of psychological nursing intervention on the quality of life of AIDS patients. Methods: The experimental studies about the influence of psychological nursing intervention on the quality of life of AIDS patients were systematically retrieved in the following databases: PubMed, Web of Science, Cochrane Library, Chinese biomedical literature database (CBM), China journal full text database (CNKI), Wanfang database and VIP Chinese science and technology periodical database (VIP)...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738316/-what-kept-me-going-a-qualitative-study-of-avoidant-responses-to-war-related-adversity-and-perpetration-of-violence-by-former-forcibly-recruited-children-and-youth-in-the-acholi-region-of-northern-uganda
#17
Helle Harnisch, Edith Montgomery
This qualitative study investigates what, according to 36 former forcibly recruited women and men, enabled them to "keep on going" during and after their forced recruitment in the twenty-year-long civil war in northern Uganda. Furthermore, the study conveys the ways most of the former forcibly recruited kept on going and today cope with ongoing war-related adversity and difficult reintegration processes without relying on psycho-social intervention. Thirty-five of the 36 women and men were forcibly recruited when they were children by the Lord's Resistance Army (LRA) from the Acholi region of northern Uganda...
July 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28737893/uncondensed-graphitic-carbon-nitride-on-reduced-graphene-oxide-for-oxygen-sensing-via-a-photoredox-mechanism
#18
James E Ellis, Dan C Sorescu, Seth C Burkert, David L White, Alexander Star
Melon, a polymeric, uncondensed graphitic carbon nitride with a two-dimensional structure has been coupled with reduced graphene oxide (rGO) to create an oxygen chemiresistor sensor that is active under UV photoactivation. Oxygen gas is an important sensor target in a variety of areas including industrial safety, combustion process monitoring, as well as environmental and biomedical fields. Due to the intimate electrical interface formed between melon and rGO, charge transfer of photoexcited electrons occurs between the two materials when under UV (λ=365 nm) irradiation...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28737465/the-effect-of-ozone-gas-sterilization-on-the-properties-and-cell-compatibility-of-electrospun-polycaprolactone-scaffolds
#19
Carolina Fracalossi Rediguieri, Paul A De Bank, Maria Helena Ambrosio Zanin, Patrícia Leo, Natalia Neto Pereira Cerize, Adriano Marim de Oliveira, Terezinha de Jesus Andreoli Pinto
The growing area of tissue engineering has the potential to alleviate the shortage of tissues and organs for transplantation, and electrospun biomaterial scaffolds are extremely promising devices for translating engineered tissues into a clinical setting. However, to be utilized in this capacity, these medical devices need to be sterile. Traditional methods of sterilization are not always suitable for biomaterials, especially as many commonly used biomedical polymers are sensitive to chemical-, thermal- or radiation-induced damage...
July 24, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28737336/-reorientation-of-health-services-and-health-promotion-a-review-of-the-situation
#20
Hassane Alami, Marie-Pierre Gagnon, El-Kebir Ghandour, Jean-Paul Fortin
<ce:para>The Ottawa Charter constitutes a major turning point in the world’s vision of health, resources and the strategies to be implemented in order to respond to the populations expectations in this field. However, these expectations are no longer limited to the conventional biomedical concept of health, strongly care-oriented and focused on diseases. They currently integrate prevention of diseases and health promotion. Five main strategic actions have been identified to achieve these goals: 1) elaboration of public health policies; 2) creation of supportive environments; 3) strengthening of community actions; 4) development of individual skills; and 5) reorientation of health services...
April 27, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
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