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https://www.readbyqxmd.com/read/28231405/three-dimensional-printing-of-x-ray-computed-tomography-datasets-with-multiple-materials-using-open-source-data-processing
#1
Ian M Sander, Matthew T McGoldrick, My N Helms, Aislinn Betts, Anthony van Avermaete, Elizabeth Owers, Evan Doney, Taimi Liepert, Glen Niebur, Douglas Liepert, W Matthew Leevy
Advances in three-dimensional (3D) printing allow for digital files to be turned into a "printed" physical product. For example, complex anatomical models derived from clinical or pre-clinical X-ray computed tomography (CT) data of patients or research specimens can be constructed using various printable materials. Although 3D printing has the potential to advance learning, many academic programs have been slow to adopt its use in the classroom despite increased availability of the equipment and digital databases already established for educational use...
February 23, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28231035/biologically-relevant-heterogeneity-metrics-and-practical-insights
#2
Albert Gough, Andrew M Stern, John Maier, Timothy Lezon, Tong-Ying Shun, Chakra Chennubhotla, Mark E Schurdak, Steven A Haney, D Lansing Taylor
Heterogeneity is a fundamental property of biological systems at all scales that must be addressed in a wide range of biomedical applications, including basic biomedical research, drug discovery, diagnostics, and the implementation of precision medicine. There are a number of published approaches to characterizing heterogeneity in cells in vitro and in tissue sections. However, there are no generally accepted approaches for the detection and quantitation of heterogeneity that can be applied in a relatively high-throughput workflow...
March 2017: SLAS Discov
https://www.readbyqxmd.com/read/28229593/development-of-laser-structured-liquid-infused-titanium-with-strong-biofilm-repellent-properties
#3
Katharina Doll, Elena Fadeeva, Joern Schaeske, Tobias Ehmke, Andreas Winkel, Alexander Heisterkamp, Boris N Chichkov, Meike Stiesch, Nico S Stumpp
Medical implants are commonly used in modern medicine but still harbor the risk of microbial infections caused by bacterial biofilms. As their retrospective treatment is difficult, there is a need for biomedical materials, which inhibit bacterial colonization from the start without using antibacterial agents, as these can promote resistance development. The promising concept of slippery liquid-infused porous surfaces (SLIPS) possesses enormous potential for this purpose. In the present study, this principle was applied to titanium, a common material in implantology, and its biofilm-repellent properties were demonstrated...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229486/biomineralization-from-material-tactics-to-biological-strategy
#4
REVIEW
Shasha Yao, Biao Jin, Zhaoming Liu, Changyu Shao, Ruibo Zhao, Xiaoyu Wang, Ruikang Tang
Biomineralization is an important tactic by which biological organisms produce hierarchically structured minerals with marvellous functions. Biomineralization studies typically focus on the mediation function of organic matrices on inorganic minerals, which helps scientists to design and synthesize bioinspired functional materials. However, the presence of inorganic minerals may also alter the native behaviours of organic matrices and even biological organisms. This progress report discusses the latest achievements relating to biomineralization mechanisms, the manufacturing of biomimetic materials and relevant applications in biological and biomedical fields...
February 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28229350/-set-in-stone-or-ray-of-hope-parents-beliefs-about-cause-and-prognosis-after-genomic-testing-of-children-diagnosed-with-asd
#5
Marian Reiff, Eva Bugos, Ellen Giarelli, Barbara A Bernhardt, Nancy B Spinner, Pamela L Sankar, Surabhi Mulchandani
Despite increasing utilization of chromosomal microarray analysis (CMA) for autism spectrum disorders (ASD), limited information exists about how results influence parents' beliefs about etiology and prognosis. We conducted in-depth interviews and surveys with 57 parents of children with ASD who received CMA results categorized as pathogenic, negative or variant of uncertain significance. Parents tended to incorporate their child's CMA results within their existing beliefs about the etiology of ASD, regardless of CMA result...
February 22, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28229306/behavioral-and-social-sciences-at-the-national-institutes-of-health-adoption-of-research-findings-in-health-research-and-practice-as-a-scientific-priority
#6
William T Riley
The National Institutes of Health's Office of Behavioral and Social Sciences Research (OBSSR) recently released its Strategic Plan for 2017 to 2021. This plan highlights three scientific priorities: (1) improve the synergy of basic and applied behavioral and social sciences research, (2) enhance and promote the research infrastructure, methods, and measures needed to support a more cumulative and integrated approach to behavioral and social sciences research, and (3) facilitate the adoption of behavioral and social sciences research findings in health research and in practice...
February 22, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28229227/population-structure-and-infectious-disease-risk-in-southern-africa
#7
REVIEW
Caitlin Uren, Marlo Möller, Paul D van Helden, Brenna M Henn, Eileen G Hoal
The KhoeSan populations are the earliest known indigenous inhabitants of southern Africa. The relatively recent expansion of Bantu-speaking agropastoralists, as well as European colonial settlement along the south-west coast, dramatically changed patterns of genetic diversity in a region which had been largely isolated for thousands of years. Owing to this unique history, population structure in southern Africa reflects both the underlying KhoeSan genetic diversity as well as differential recent admixture. This population structure has a wide range of biomedical and sociocultural implications; such as changes in disease risk profiles...
February 22, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28228350/impact-of-technical-and-assay-variation-on-reporting-of-hemolysis-in-stored-red-blood-cell-products
#8
Ruqayyah J Almizraq, Qi Long Yi, Jason P Acker
BACKGROUND: Hemolysis of RBCs is an important measure of product quality and is influenced by donor factors, blood component manufacturing and storage. Percent hemolysis is determined using hematocrit (Hct), supernatant Hb (SHb) and total Hb (THb), each of which can be measured using a variety of methods. METHODS: Sixteen members of an international collaborative were surveyed to understand equipment and procedural variation in hemolysis testing. In a laboratory-based evaluation, we examined how hemolysis was impacted by: measurement of Hct, SHb, THb and number and force of centrifugations for SHb preparation...
February 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28228077/antioxidant-nanoplatforms-for-dermal-delivery-melatonin
#9
Aroha Belen Sánchez Milán, Ana C Calpena Campmany, Beatriz Clares Naveros
Melatonin (MLT) is emerging as a promising therapeutic agent, mainly due to its role as antioxidant. Substantial evidences show that melatonin is potentially effective on a variety of diseases as cancer, inflammation and neurodegenerative diseases. The excellent antioxidant capacity with pharmacokinetics characteristics and the emerging search for new pharmaceutical nanotechnology based systems, make it particularly attractive to elaborate nanoplatforms based on MLT for biomedical or cosmetic dermal applications...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28228012/investigation-of-thermally-induced-cellular-ablation-and-heat-response-triggered-by-planar-mos2-based-nanocomposite
#10
Shinya Ariyasu, Jing Mu, Xiao Zhang, Ying Huang, Edwin K L Yeow, Hua Zhang, Bengang Xing
In comparison to conventional tumor treatment methods, photothermal therapy (PTT) is one of the innovative therapeutic strategies that employs light to produce the localized heat for targeted ablation of cancer cells. Among various kinds of heat generation nanomaterials, transition metal dichalcogenide nanosheets, especially-molybdenum disulfide (MoS2) have recently been investigated as one of the promising PTT candidates because of their strong absorbance in the near-infrared (NIR) tissue transparency window and excellent photothermal conversion capability...
February 23, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28227935/heart-sound-segmentation-using-fractal-decomposition
#11
Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan, Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan
In order to assist cardiac diagnosis by phonocardiography, the automated identification of fundamental heart sounds for heart beat segmentation in a cardiac cycle plays a significant role in signal processing. Recent advancements in signal processing have also shown the potential of multifractality in biomedical applications. Hence, in this paper, the multifractal property of heart sounds is utilized to identify first and second heart sounds. The root mean square (rms) fluctuation used to obtain multifractal/singularity spectrum is used to decompose the heart sound into its own fractally-important components in time domain along with simultaneous Gaussianity test to filter out fundamental components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227856/multiquadric-spline-based-interactive-segmentation-of-vascular-networks
#12
Sachin Meena, V B Surya Prasath, Yasmin M Kassim, Richard J Maude, Olga V Glinskii, Vladislav V Glinsky, Virginia H Huxley, Kannappan Palaniappan, Sachin Meena, V B Surya Prasath, Yasmin M Kassim, Richard J Maude, Olga V Glinskii, Vladislav V Glinsky, Virginia H Huxley, Kannappan Palaniappan, Virginia H Huxley, Yasmin M Kassim, Sachin Meena, Kannappan Palaniappan, Vladislav V Glinsky, Olga V Glinskii, Richard J Maude, V B Surya Prasath
Commonly used drawing tools for interactive image segmentation and labeling include active contours or boundaries, scribbles, rectangles and other shapes. Thin vessel shapes in images of vascular networks are difficult to segment using automatic or interactive methods. This paper introduces the novel use of a sparse set of user-defined seed points (supervised labels) for precisely, quickly and robustly segmenting complex biomedical images. A multiquadric spline-based binary classifier is proposed as a unique approach for interactive segmentation using as features color values and the location of seed points...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227726/mobile-teleradiology-system-suitable-for-m-health-services-supporting-content-and-semantic-based-image-retrieval-on-a-grid-infrastructure
#13
Alexandra La Cruz, Ruben Medina, Francisco Vega, Wilson Perez, Blanca Ochoa, Victor Saquicela, Mauricio Espinoza, Lizandro Solano-Quinde, Maria-Esther Vidal, Alexandra La Cruz, Ruben Medina, Francisco Vega, Wilson Perez, Blanca Ochoa, Victor Saquicela, Mauricio Espinoza, Lizandro Solano-Quinde, Maria-Esther Vidal, Victor Saquicela, Francisco Vega, Mauricio Espinoza, Lizandro Solano-Quinde, Blanca Ochoa, Maria-Esther Vidal, Alexandra La Cruz, Ruben Medina, Wilson Perez
Teleradiology systems tackle the problem of transferring radiological images between medical image workstations for facilitating different medical activities, e.g., diagnosis, treatment and follow up a patient, medical training, or consulting second opinion. Nowadays, m-Health (aka mobile health) is becoming popular because of high quality of mobile displays, although remains a work in progress. In this paper a mobile teleradiology system is reported, which main contribution is the development of a platform: (1) supported by a Grid infrastructure, (2) using biomedical ontologies for adding semantic annotations on medical images, and (3) supporting semantic and content-based image retrieval...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227705/an-affordable-cuff-less-blood-pressure-estimation-solution
#14
Monika Jain, Niranjan Kumar, Sujay Deb, Monika Jain, Niranjan Kumar, Sujay Deb, Monika Jain, Sujay Deb, Niranjan Kumar
This paper presents a cuff-less hypertension pre-screening device that non-invasively monitors the Blood Pressure (BP) and Heart Rate (HR) continuously. The proposed device simultaneously records two clinically significant and highly correlated biomedical signals, viz., Electrocardiogram (ECG) and Photoplethysmogram (PPG). The device provides a common data acquisition platform that can interface with PC/laptop, Smart phone/tablet and Raspberry-pi etc. The hardware stores and processes the recorded ECG and PPG in order to extract the real-time BP and HR using kernel regression approach...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227676/initial-experiments-of-a-128-channel-fpga-and-pc-based-ultrasound-imaging-system-for-teaching-and-research-activities
#15
Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa, Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa, Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa
Although widely employed in medical diagnostic applications, most of the available commercial ultrasound (US) scanners do not always fit the needs of research users. Access to raw US data, portability, flexibility and advanced user control are essential features to explore alternative biomedical signal and imaging processing algorithms. In this paper, we present the initial results of a reconfigurable, cost-effective and modular 128-channel FPGA and PC-based US system, specifically designed for teaching and medical imaging research...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227622/energy-harvesting-from-human-walking-to-power-biomedical-devices-using-oscillating-generation
#16
Jose A Montoya, Dulce M Mariscal, Edwar Romero, Jose A Montoya, Dulce M Mariscal, Edwar Romero, Dulce M Mariscal, Jose A Montoya, Edwar Romero
This work summarizes the energy generation limits from walking employing a pendulum-based generation system. Self-winding wristwatches have exploited successfully this energy input technique for decades. Pendulum-based planar devices use the rotation to produce energy for inertial generators. Then the oscillations of body motion during locomotion present an opportunity to extract kinetic energy from planar generators. The sinusoidal motion of the center of gravity of the body, on the sagittal and frontal planes, and the limbs swinging are compliant with oscillating devices...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227587/optimal-frequency-for-powering-millimeter-sized-biomedical-implants-inside-an-inductively-powered-homecage
#17
Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani, Hesam Sadeghi Gougheri, Mehdi Kiani
This paper presents the optimal design and operation frequency (f) of an inductively-powered homecage for powering biomedical devices with millimeter (mm) dimensions, implanted inside the body of freely-behaving small animal subjects, for longitudinal behavioral neuroscience and electrophysiology experiments. In order to improve the power transmission efficiency (PTE) for powering mm-sized implants, the geometry of the multi-coil inductive links in the form of 3- and 4-coil links as well as fp need to be co-optimized...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227586/inductive-power-transmission-to-millimeter-sized-biomedical-implants-using-printed-spiral-coils
#18
Ahmed Ibrahim, Mehdi Kiani, Ahmed Ibrahim, Mehdi Kiani, Ahmed Ibrahim, Mehdi Kiani
The operation frequency (f) has been a key parameter in optimizing wireless power transmission links for biomedical implants with millimeter (mm) dimensions. This paper studies the feasibility of using printed spiral coils (PSCs) for powering mm-sized implants with high power transmission efficiency (PTE) at different fps. Compared to wire-wound coils (WWCs), using a PSC in the implant side allows batch fabrication on rigid or flexible substrates, which can also be used as a platform for integrating implant components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227521/eeg-analysis-via-multiscale-lempel-ziv-complexity-for-seizure-detection
#19
N Sertac Artan, N Sertac Artan, N Sertac Artan
Robust seizure detection and seizure prediction continues to be a challenge. Lempel-Ziv Complexity (LZC) is one of the features that has shown to be relevant in seizure detection. Recent work has shown that augmenting LZC can be beneficial to emphasize variations in amplitude or frequency when analyzing biomedical signals. In this paper, we present a first look into evaluating the feasibility of using a recently proposed feature stemmed from LZC, namely the Multiscale Lempel-Ziv Complexity (MLZC) for seizure detection...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227492/biomems-based-coding-for-secure-medical-diagnostic-devices
#20
Tuan Le, Gabriel Salles-Loustau, Laleh Najafizadeh, Mehdi Javanmard, Saman Zonouz, Tuan Le, Gabriel Salles-Loustau, Laleh Najafizadeh, Mehdi Javanmard, Saman Zonouz, Saman Zonouz, Gabriel Salles-Loustau, Laleh Najafizadeh, Tuan Le, Mehdi Javanmard
Trustworthy and usable point-of-care solutions require not only effective disease diagnostic procedures to ensure delivery of rapid and accurate outcomes, but also lightweight privacy-preserving capabilities. In this paper, we present a Biomedical Microelectromachanical System (BioMEMS)-based sensor for portable, inexpensive smartphone-based biomarker detection. The biosensor presented here provides the ability for signal encryption at the physical sensor level to ensure patient's diagnostic confidentiality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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