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Christian Enders, Achim Schneider, Oliver Keis, Claudia Grab-Kroll, Max Loidl, Jürgen Kampmeier, Gerhard K Lang, Jens Ulrich Werner
BACKGROUND: An increased demand for young physicians in Germany is causing increased competition to attract the best minds, even during their undergraduate studies. Therefore, it is the task of the university hospitals to offer their students the best possible courses in order to arouse interest in the relevant subject area. We therefore examined the impact of an ophthalmosurgical wet lab on teaching undergraduate medical students. MATERIAL/METHODS: Undergraduate medical students were offered voluntary participation in the ophthalmosurgical wet lab during an ophthalmology block week...
July 19, 2018: Klinische Monatsblätter Für Augenheilkunde
Dagmar Beyrau, Helmut Schaaf, Gerhard Hesse
The diagnosis and treatment of tinnitus requires professional competence in neuro-otology and also an appropriate and comprehensible clarification for the individual patient.According to the Tinnitus-Guidelines of 2015 the counselling by the physician in charge is essential regarding the individual aetiopathogenesis, as well as the patient's individual coping mechanism with tinnitus, the prognosis, exacerbating factors and also as to the damaging impact on the ear.Therefore the therapeutic aim is to depathologize the symptom tinnitus and to provide an explanation and a context in the contemporary approved and scientific conception...
July 19, 2018: Laryngo- Rhino- Otologie
Juan Jin, Kang Hu, Meiyu Ye, Diandian Wu, Qiang He
BACKGROUND/AIMS: The purpose of this study was to investigate the impact of rapamycin (RAP) on autophagy in podocytes and the therapeutic effects of RAP on idiopathic membranous nephropathy (IMN). METHODS: We established an in vitro model of IMN by preconditioning mouse podocytes with puromycin aminonucleoside (PAN). A Cell Counting Kit-8 was used to detect the proliferation of each group of podocytes. Podocyte apoptosis was analyzed by flow cytometry via annexin V/propidium iodide dual staining...
July 19, 2018: Cellular Physiology and Biochemistry
Sebastião Freitas de Medeiros, Matheus Antônio Souto de Medeiros, Cinthia Marenza Ormond, Jacklyne Silva Barbosa, Márcia Marly Winck Yamamoto
BACKGROUND/AIMS: Definitive polycystic ovary syndrome (PCOS) diagnosis should exclude thyroid dysfunctions. The purpose of the study is to examine the impact of subclinical hypothyroidism on the characteristics of PCOS patients. METHODS: A meta-analysis of the published observational studies was conducted. Medline, Scopus, and Cochrane database search was performed to identify the studies that compared euthyroid PCOS and subclinical hypothyroidism (SCH)-PCOS patients...
2018: Gynecologic and Obstetric Investigation
Sangkyu Kim, S Michal Jazwinski
The gut microbiota shows a wide inter-individual variation, but its within-individual variation is relatively stable over time. A functional core microbiome, provided by abundant bacterial taxa, seems to be common to various human hosts regardless of their gender, geographic location, and age. With advancing chronological age, the gut microbiota becomes more diverse and variable. However, when measures of biological age are used with adjustment for chronological age, overall richness decreases, while a certain group of bacteria associated with frailty increases...
July 19, 2018: Gerontology
Omri Nativ, Zaher Bahouth, Edmond Sabo, Sarel Halachmi, Boaz Moskovitz, Elias G Hellou, Zaid Abassi, Ofer Nativ
INTRODUCTION: The aim of our study was to examine the influence of tumor complexity and operative variables on the degree and rate of post-nephron sparing surgery (NSS) acute kidney injury (AKI). METHODS: We retrospectively reviewed the records of 477 patients who underwent NSS for enhancing renal masses in our institution. AKI was determined using the latest definition by AKIN and RIFLE criteria. Serum creatinine was assessed daily starting from day 1 post-surgery and until discharge (usually on postoperative day 3)...
July 19, 2018: Urologia Internationalis
Paula Jimenez-Fonseca, Sebastian Krug, Gianluca Tamagno, F Fierro Maya, A Monleon Getino, C I Rodriguez Casado, Frederico Costa, Wouter W de Herder, Henning Jann
<br>Pancreatic neuroendocrine tumours (pNETs) represent rare neoplasms of all NETs often presenting without functional activity. Many sporadic non-functioning pNET patients are already metastatic at the time of diagnosis, and the therapeutic approach to such patients is mostly palliative. In this international, multicenter, retrospective cohort study we assessed the prognostic value of a set of anthropometric, clinical, biochemical, radiological, and pathological parameters at baseline and the impact of the therapeutic strategies on the survival of patients with sporadic grade 1/2, stage IV, non-functioning pNETs...
July 19, 2018: Neuroendocrinology
Morgane Danion, Stéphane Le Floch, Joelle Cabon, Lénaïg Louboutin, Thierry Morin
In the Transchem project, rainbow trout genitors were exposed to environmental concentrations of pendimethalin over a period of 18 months and two new first generations of offspring, F1_2013 and F1_2014, were obtained. We investigated the impact of direct chemical exposure on juveniles as well as the potential cumulative transgenerational and direct effects on the larval development and on the pathogen susceptibility of offspring. Depending on the chemical treatment or not of the adults, their offspring were distributed in the tanks of our experimental system, in two batches i...
July 10, 2018: Aquatic Toxicology
Feng-Jiao Peng, Noël J Diepens, Chang-Gui Pan, Sally A Bracewell, Guang-Guo Ying, Daniel Salvito, Henriette Selck, Paul J Van den Brink
Triclosan (TCS) is an antibacterial agent that is commonly used in personal care products. Because of its sediment-binding properties, TCS exposure presents a potential threat to sediment-dwelling aquatic organisms. Currently our knowledge of the fate and effects of sediment-associated TCS in aquatic systems is limited. To understand the impact of sediment-associated TCS, we used microcosms to assess effects of TCS exposure on a diverse range of organisms selected to mimic a subtropical community, with an exposure period of 28 days...
July 11, 2018: Aquatic Toxicology
Luchuan Chen, Chaojun Lei, Zhongjian Li, Bin Yang, Xingwang Zhang, Lecheng Lei
Electrochemical advanced oxidation processes (EAOPs) based on hydroxyl radicals (OH) have some limitations when they are applied to real wastewater treatment, such like strict requirements on pH (acidic electrolyte) and high energy consumption. Compared to OH, Sulfate radicals (SO4 - ) have high redox potential in wider range of pH (2-9). In this study, SO4 - were efficiently produced by electrochemical activation of SO4 2- at boron doped diamond (BDD) anode. The degradation rate of 2,4-DCP (k = 0.828 ± 0...
July 12, 2018: Chemosphere
Yuting Chen, Na Zhu, Yuyi Luo, Keqi Hu, Yungang Liu
Polychlorinated biphenyls (PCBs) as a group of persistent organic pollutants are confirmed human carcinogens; however, their mutagenicity remains mostly unknown. We have reported the mutagenicity of some PCBs with one to four chlorines in mammalian cells expressing human CYP2E1. To further explore the structural requirements for the mutagenicity of PCBs, eight tri- and tetrachlorobiphenyls untested before were investigated for the induction of gene mutations and micronuclei in a V79-derived cell line expressing both human CYP2E1 and sulfotransferase (SULT) 1A1 (V79-hCYP2E1-hSULT1A1), with SULT1A1 activity inhibited by pentachlorophenol, a potent SULT1 inhibitor...
July 11, 2018: Chemosphere
Sara Leitão, Vera J C Mc Carthy, Birgit A Greiner
BACKGROUND/AIMS: Health and Safety Practitioners (HSPs), as frontline professionals advocating for health and safety (HS) working conditions, have crucial roles for the wellbeing of employees. However, research studying HSPs psychosocial working conditions - i.e. job demands, control and support (JDCS) -, safety climate (SC) and their impact on HSPs health and wellbeing is scarce. This novel study aims to examine the link of JDCS and SC with HSPs' health, wellbeing and efficacy. METHODS: A web-survey was completed by 879 HSPs, members of the Institution of Occupational Safety and Health (IOSH) in Ireland and the UK...
July 16, 2018: Accident; Analysis and Prevention
Bo Yu, Yuren Chen, Shan Bao, Duo Xu
Owing to constrained topography and road geometry, mountainous highways are subjected to frequent traffic accidents, and these crashes have relatively high mortality rates. In middle and high mountains, most roads are two-lane highways. Most two-lane mountain highways are located in rural areas in China, where traffic volume is relatively small; namely, traffic accidents are mainly related to the design of roads, rather than the impact of traffic flow. Previous studies primarily focused on the relationship between actual road geometry and traffic safety...
July 16, 2018: Accident; Analysis and Prevention
Keyong Huang, Qingyang Xiao, Xia Meng, Guannan Geng, Yujie Wang, Alexei Lyapustin, Dongfeng Gu, Yang Liu
Exposure to fine particulate matter (PM2.5 ) remains a worldwide public health issue. However, epidemiological studies on the chronic health impacts of PM2.5 in the developing countries are hindered by the lack of monitoring data. Despite the recent development of using satellite remote sensing to predict ground-level PM2.5 concentrations in China, methods for generating reliable historical PM2.5 exposure, especially prior to the construction of PM2.5 monitoring network in 2013, are still very rare. In this study, a high-performance machine-learning model was developed directly at monthly level to estimate PM2...
July 11, 2018: Environmental Pollution
Cheng Huang, Qingyao Hu, Hanyu Wang, Liping Qiao, Sheng'ao Jing, Hongli Wang, Min Zhou, Shuhui Zhu, Yingge Ma, Shengrong Lou, Li Li, Shikang Tao, Yingjie Li, Diming Lou
On-board emissions measurements were performed on a Handysize-class bulk carrier operating under real-world conditions. Emission factors (EFs) were determined for criteria pollutants such as NOx , CO, total hydrocarbons (THC), and PM; PM composition, including organic and elemental carbon (OC and EC), inorganic species, and a variety of organic compounds and VOC species (including alkanes, alkenes, single-ring aromatics, and oxygenated VOCs) were also analyzed. To investigate the impacts of engine type, fuel, and operating conditions on emissions, measurements were conducted on one main and one auxiliary engines using low- and high-sulfur fuels (LSF and HSF) under actual operating conditions, including at-berth, maneuvering, and cruising at different engine loads...
July 16, 2018: Environmental Pollution
Dennis Mazingi, George C Jakanani, Prudance Mushayavanhu
INTRODUCTION: The Morel-Lavallée lesion is an infrequently described, post-traumatic closed de-gloving wound that results from separation of the skin and subcutaneous tissues from the underlying deep fascia as a result of shearing forces that tear perforating vessels and lymphatics. This condition is rare in children and to our knowledge it represents the youngest case of Morel-Lavallée lesion yet reported. PRESENTATION OF CASE: We report on a twelve-month-old girl who presented after a motor vehicle accident with a tender fluctuant mass of the back and buttocks...
July 12, 2018: International Journal of Surgery Case Reports
Belén Abarrategui, Luciana Rodrigues De Marchi, Mirian Salvadori Bittar Guaranha, Elza Márcia Targas Yacubian
PURPOSE: To characterize semiology and EEG features of praxis-induced (PI) myoclonia and to describe the subjective perception of juvenile myoclonic epilepsy (JME) patients with this reflex trait. METHODS: Patients with JME who presented myoclonia during a Video-EEG Neuropsychological Protocol were selected. We analyzed the semiology of upper limbs myoclonia and the ictal EEG patterns on Video-EEG. We explored the subjective aspects of PI by performing a semi-structured interview to each patient...
June 30, 2018: Seizure: the Journal of the British Epilepsy Association
Gwenny Thomassen, Miet Van Dael, Steven Van Passel
This study performs an environmental techno-economic assessment (ETEA) for multiple microalgae biorefinery concepts at different locations, those being Belgium and India. The ETEA methodology, which integrates aspects of the TEA and LCA methodologies and provides a clear framework for an integrated assessment model, has been proposed and discussed. The scenario in India has a higher profitability with a NPV of €40 million over a period of 10 years, while the environmental impact in Belgium is lower. The inclusion of a medium recycling step provides the best scenario from both perspectives...
July 10, 2018: Bioresource Technology
Giuliana D'Imporzano, Roberto Pilu, Luca Corno, Fabrizio Adani
Maize silage contributes to biogas production in Lombardy Region (400 anaerobic digestion plants) employing 47,000 Ha (Production Model - PM1). Reducing the area devoted to this energy crop is a goal to free soil for food production. Double cropping (PM2) and Arundo donax L. (PM3) have been proposed and tested to measure the impacts for the three Production Models by Life Cycle Assessment (LCA). The impact category related to Climate Change remained stable for PM2 while it decreased by 17% for Arundo donax L...
July 12, 2018: Bioresource Technology
Punitha Subramaniam, Jadwiga Rogowska, Jennifer DiMuzio, Melissa Lopez-Larson, Erin McGlade, Deborah Yurgelun-Todd
BACKGROUND: Prevalence of marijuana (MJ) use among adolescents has been on the rise. MJ use has been reported to impact several brain regions, including frontal regions such as the orbitofrontal cortex (OFC). The OFC is involved in emotion regulation and processing and has been associated with symptoms of depression and anxiety. Therefore, we hypothesized that adolescent MJ users would show disruptions in OFC connectivity compared with healthy adolescents (HC) which would be associated with symptoms of mood and anxiety...
July 3, 2018: Journal of Affective Disorders
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