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Farah Tamirou, Séverine Nieuwland Husson, Damien Gruson, Frédéric Debiève, Bernard R Lauwerys, Frédéric A Houssiau
OBJECTIVE: The low-dose intravenous (IV) cyclophosphamide (CY) Euro-Lupus (EL) regimen (cumulative dose of 3 g) was developped to reduce gonadal toxicity. To address the possibility of a marginal effect on the ovarian reserve, we measured serum anti-Müllerian hormone (AMH) titers in patients suffering from systemic lupus erythematosus (SLE) treated with the EL regimen and compared them to those measured in patients treated with higher doses of IVCY or never treated with IVCY. METHODS: Serum AMH levels were measured by ELISA in a cohort of 155 premenopausal SLE patients, of whom 30 had received the EL regimen and 24 higher doses of IVCY...
February 24, 2017: Arthritis & Rheumatology
N Moore, M Moreno Gonzales, K Bonner, B Smith, W Park, M Stegall
Plasma cells (PCs) are a major source of alloantibody in transplant patients and are resistant to current therapy. Since receptor/ligand interactions in stromal microenvironments play important roles in the localization, development and survival of normal PCs, we hypothesized that interfering with CXCR4/CXCL12 interactions with plerixafor might cause PC depletion and enhance the efficacy of the proteasome inhibitor, bortezomib. PCs in mouse spleen, bone marrow and peripheral blood demonstrated CXCR4 expression...
February 24, 2017: American Journal of Transplantation
Malik Mossa-Basha, Clara Lee
Introduction CT angiogram (CTA) is widely believed to improve operative time and flap outcomes for perforator flap breast reconstruction, but the quality of the evidence is not known. We conducted a systematic review of the efficacy of preoperative CTA for abdominal perforator flap breast reconstruction. Methods Inclusion criteria included published articles in English, CTA group, and control group, between 2000 and March 2013. Medline and PubMed were queried. Study quality criteria were developed based on standards of internal and external validity...
February 24, 2017: Journal of Reconstructive Microsurgery
Carmen Dingemann, Janine Dietrich, Jan Zeidler, Jochen Blaser, Jan Hendrik Gosemann, Martin Lacher, Benno Ure
Introduction We aimed to analyze for the first time the characteristics, treatment modalities, and outcomes in infants with congenital abdominal wall defects (CAWDs) in Germany and to compare the results with current literature reports. Patients and Methods Data of a health insurance covering approximately 10% of the German population were analyzed. Patients who had undergone CAWD closure during a period of nearly 6 years were included. Surgical approach was categorized into primary versus secondary closure...
February 24, 2017: European Journal of Pediatric Surgery
Rajiv C McCoy, Jon Wakefield, Joshua M Akey
Regulatory variation influencing gene expression is a key contributor to phenotypic diversity, both within and between species. Unfortunately, RNA degrades too rapidly to be recovered from fossil remains, limiting functional genomic insights about our extinct hominin relatives. Many Neanderthal sequences survive in modern humans due to ancient hybridization, providing an opportunity to assess their contributions to transcriptional variation and to test hypotheses about regulatory evolution. We developed a flexible Bayesian statistical approach to quantify allele-specific expression (ASE) in complex RNA-seq datasets...
February 23, 2017: Cell
Juliette Fédry, Yanjie Liu, Gérard Péhau-Arnaudet, Jimin Pei, Wenhao Li, M Alejandra Tortorici, François Traincard, Annalisa Meola, Gérard Bricogne, Nick V Grishin, William J Snell, Félix A Rey, Thomas Krey
Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane protein HAP2-GCS1 has been postulated to function in membrane merger. Its presence in the major eukaryotic taxa-animals, plants, and protists (including important human pathogens like Plasmodium)-suggests that many eukaryotic organisms share a common gamete fusion mechanism. Here, we report combined bioinformatic, biochemical, mutational, and X-ray crystallographic studies on the unicellular alga Chlamydomonas reinhardtii HAP2 that reveal homology to class II viral membrane fusion proteins...
February 23, 2017: Cell
Zoulikha Bouchiba, Zineb Faiza Boukhatem, Zohra Ighilhariz, Nouria Derkaoui, Benaissa Kerdouh, Hanaa Abdelmoumen, Younes Abbas, Mustapha Missbah El Idrissi, Abdelkader Bekki
A total of 51 bacterial strains were isolated from root nodules of Scorpiurus muricatus sampled from six regions of western Algeria. Strains diversity was assessed by rep-PCR amplification fingerprinting which had allowed grouping the isolates into 28 different clusters. Partial Nucleotide sequencing of 16SrRNA gene and BLAST analysis revealed that root nodules of Scorpiurus muricatus were colonized by different species close to Rhizobium vignae, Rhizobium radiobacter, Rhizobium leguminosarum, Phyllobacterium ifriquiensis, Phyllobacterium endophyticum, Starkeya sp...
February 24, 2017: Canadian Journal of Microbiology
Justin G Coughlin, Lucy A Rose, Daniel J Bain, Emily M Elliott
Emissions of nitrogen oxides (NOx) in the United States (U.S.) from large stationary sources, such as electric generating units, have decreased since 1995, driving decreases in nitrogen deposition. However, increasing NOx emissions from emerging industries, such as unconventional natural gas (UNG) extraction, could offset stationary source emission reductions in shale gas producing regions of the U.S. The Marcellus Shale in the northeastern U.S. has seen dramatic increases in the number of wells and associated natural gas production during the past ten years...
February 24, 2017: Environmental Science & Technology
Aleksandra Lilic, Simona Bennici, Jean-Fraçois Devaux, Jean-Luc Dubois, Aline Auroux
Oxidative coupling of methanol and ethanol represents a new route to produce acrolein. In this work, the overall reaction was decoupled in 2 steps, the oxidation and the aldolization, using two consecutive reactors in order to investigate the role of acid/base properties of silica-supported oxide catalysts. The oxidation of a mixture of methanol and ethanol to formaldehyde and acetaldehyde was performed on a FeMoOx catalyst, then the products mixture was sent in a second reactor, without intermediate separation, where the aldol-condensation and dehydration to acrolein were carried out on the supported oxides...
February 24, 2017: ChemSusChem
Guiyan Wang, Chao Wang, Man Qin
BACKGROUND/AIM: Complicated crown fractures are relatively common in children where the maintenance of the pulp is especially important in young permanent teeth. The aim of this study was to analyze the pulp prognosis of permanent teeth with complicated crown fractures treated with conservative pulp treatment in adolescents. MATERIAL AND METHODS: Complete dental records of teeth with complicated crown fractures treated with conservative pulp treatment were obtained...
February 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Simo Raiskila, Anna Axelin, Liis Toome, Sylvia Caballero, Bente Silnes Tandberg, Rosario Montirosso, Erik Normann, Boubou Hallberg, Björn Westrup, Uwe Ewald, Liisa Lehtonen
AIM: Little is known about the amount of physical parent-infant closeness in neonatal intensive care units (NICUs) and this study explored that issue in six European countries. METHODS: The parents of 328 preterm infants were recruited in 11 NICUs in Finland, Estonia, Sweden, Norway, Italy and Spain. They filled in daily diaries about how much time they spent in the NICU, in skin-to-skin contact (SSC) and holding their babies in the first two weeks of their hospitalisation...
February 24, 2017: Acta Paediatrica
Terez Shea-Donohue, Bolin Qin, Allen Smith
Nutritional immunology, immunometabolism, and identification of novel immunotherapeutic targets, are areas of active investigation in parasitology. There is a well-documented crosstalk among immune cells and cells in metabolically active tissues that is important for homeostasis. The numbers and function of these cells are altered by obesity leading to inflammation. A variety of helminths spend some part of their life cycle in the gastrointestinal tract and even entirely enteral nematode infections exert beneficial effects on glucose and lipid metabolism...
February 24, 2017: Parasite Immunology
Lauri Puustinen, Sonja Boyd, Perttu Arkkila, Helena Isoniemi, Johanna Arola, Martti Färkkilä
BACKGROUND: Autoimmune hepatitis (AIH) often recurs after liver transplantation (LT). Our aim was to evaluate the recurrence rate of AIH after LT, impact of AIH recurrence on survival and fibrosis progression, and find risk factors for AIH recurrence. METHODS: 42 patients with AIH prior to LT with ≥1 protocol biopsy ≥1 year post-LT were included with a median follow-up of 5.0 years (1.0-17.0). Follow-up liver biopsies were re-evaluated for AIH recurrence, fibrosis progression, and cirrhosis development...
February 24, 2017: Clinical Transplantation
John F Mondanaro, Peter Homel, Baron Lonner, Jennifer Shepp, Marcela Lichtensztein, Joanne V Loewy
The treatment of pain continues to gain in saliency as a component of defining best practice in medical care. Music therapy is an integrative treatment modality that impacts patient outcomes in the treatment of spinal pain. At Mount Sinai Beth Israel, we conducted a mixed-methods study addressing the effects of music therapy interventions on the recovery of patients after spine surgery. The study combined standard medical approaches and integrative music therapy. Sixty patients (35 female, 25 male) ranging in age from 40 to 55 years underwent anterior, posterior, or anterior-posterior spinal fusion and were randomly assigned to either music therapy plus standard care (medical and nursing care with scheduled pharmacologic pain intervention) or standard care only...
January 2017: American Journal of Orthopedics
Marie Méan, Antoine Garnier, Nathalie Wenger, Julien Castioni, Gérard Waeber, Pedro Marques-Vidal
BACKGROUND: Recent implementation of electronic health records (EHR) has dramatically changed medical ward organization. While residents in general internal medicine use EHR systems half of their working time, whether computer usage impacts residents' workflow remains uncertain. We aimed to observe the frequency of task-switches occurring during resident's work and to assess whether computer usage was associated with task-switching. METHODS: In a large Swiss academic university hospital, we conducted, between May 26 and July 24, 2015 a time-motion study to assess how residents in general internal medicine organize their working day...
2017: PloS One
Emilija Marinkovic, Radmila Djokic, Ivana Lukic, Ana Filipovic, Aleksandra Inic-Kanada, Dejana Kosanovic, Marija Gavrovic-Jankulovic, Marijana Stojanovic
We demonstrated that a recombinant banana lectin (rBanLec), which structural characteristics and physiological impacts highly resemble those reported for its natural counterparts, binds murine peritoneal macrophages and specifically modulates their functional characteristics. By using rBanLec in concentrations ranging from 1 μg to 10 μg to stimulate resident (RMs) and thioglycollate-elicited (TGMs) peritoneal macrophages from BALB/c and C57BL/6 mice, we have shown that effects of rBanLec stimulation depend on its concentration but also on the functional status of macrophages and their genetic background...
2017: PloS One
Matthew Smuck, Christy Tomkins-Lane, Ma Agnes Ith, Renata Jarosz, Ming-Chih Jeffrey Kao
BACKGROUND: Accurate measurement of physical performance in individuals with musculoskeletal pain is essential. Accelerometry is a powerful tool for this purpose, yet the current methods designed to evaluate energy expenditure are not optimized for this population. The goal of this study is to empirically derive a method of accelerometry analysis specifically for musculoskeletal pain populations. METHODS: We extracted data from 6,796 participants in the 2003-4 National Health and Nutrition Examination Survey (NHANES) including: 7-day accelerometry, health and pain questionnaires, and anthropomorphics...
2017: PloS One
Nataliya Tkachenko, Stephen Jarvis, Rob Procter
Increasingly, user generated content (UGC) in social media postings and their associated metadata such as time and location stamps are being used to provide useful operational information during natural hazard events such as hurricanes, storms and floods. The main advantage of these new sources of data are twofold. First, in a purely additive sense, they can provide much denser geographical coverage of the hazard as compared to traditional sensor networks. Second, they provide what physical sensors are not able to do: By documenting personal observations and experiences, they directly record the impact of a hazard on the human environment...
2017: PloS One
Mayumi Watanabe, Akihito Shimazu, Arnold B Bakker, Evangelia Demerouti, Kyoko Shimada, Norito Kawakami
OBJECTIVES: This study of Japanese dual-earner couples examined the impact of family and job demands on one's own and one's partner's fatigue as well as gender differences in these effects. METHODS: A total of 2,502 parents (1,251 couples) were surveyed using a self-administered questionnaire. A crossover model was tested using structural equation modeling. RESULTS: The results of structural equation modeling analyses showed that both job and family demands independently exacerbated fatigue...
2017: PloS One
A M Oberbauer, G G Keller, T R Famula
Canine hip dysplasia (CHD) and elbow dysplasia (ED) impact the health and welfare of all dogs. The first formally organized assessment scheme to improve canine health centered on reducing the prevalence of these orthopedic disorders. Phenotypic screening of joint conformation remains the currently available strategy for breeders to make selection decisions. The present study evaluated the efficacy of employing phenotypic selection on breed improvement of hips and elbows using the Orthopedic Foundation for Animals complete database spanning the 1970-2015 time period...
2017: PloS One
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