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histone deacetylase reactive oxygen

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https://www.readbyqxmd.com/read/27904046/cocl2-decreases-ec-sod-expression-through-histone-deacetylation-in-cos7-cells
#1
Shuhei Hattori, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
Extracellular-superoxide dismutase (EC-SOD), one of the SOD isozymes, is negatively regulated under hypoxic conditions, and decreases in its expression may exacerbate vascular diseases. Moreover, epigenetics, such as DNA methylation and histone modifications, are known to play a critical role in the progression of cancer, type 2 diabetes, and atherosclerosis. We previously investigated the involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein kinase (MAPK) in decreases in EC-SOD expression in hypoxic COS7 cells; however, the role of epigenetics in this process currently remains unknown...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27903278/an-overview-on-the-role-of-dietary-phenolics-for-the-treatment-of-cancers
#2
REVIEW
Preethi G Anantharaju, Prathima C Gowda, Manjunatha G Vimalambike, SubbaRao V Madhunapantula
Plant derived phenolic compounds have been shown to inhibit the initiation and progression of cancers by modulating genes regulating key processes such as: (a) oncogenic transformation of normal cells; (b) growth and development of tumors; and (c) angiogenesis and metastasis. Recent studies focusing on identifying the molecular basis of plant phenolics-induced cancer cell death have demonstrated down-regulation of: (a) oncogenic survival kinases such as PI3K and Akt; (b) cell proliferation regulators that include Erk1/2, D-type Cyclins, and Cyclin Dependent Kinases (CDKs); (c) transcription factors such as NF-kβ, NRF2 and STATs; (d) histone deacetylases HDAC1 and HDAC2; and (e) angiogenic factors VEGF, FGFR1 and MIC-1...
December 1, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27864177/the-histone-deacetylase-hda-2-regulates-growth-conidiation-blue-light-perception-and-oxidative-stress-responses-in-trichoderma-atroviride
#3
Macario Osorio-Concepción, Gema Rosa Cristóbal Mondragón, Braulio Gutiérrez-Medina, Sergio Casas-Flores
: Fungal blue-light photoreceptors have been proposed as integrators of light and oxidative stress. However, additional elements participating in the integrative pathway remain to be identified. In Trichoderma atroviride, the blue-light receptor proteins BLR-1 and -2 are known to regulate gene transcription, mycelial growth and asexual development upon illumination, and recent global transcriptional analysis revealed that the histone deacetylase encoding gene hda-2 is induced by light...
November 18, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27826689/%C3%AE-hydroxybutyrate-in-the-brain-one-molecule-multiple-mechanisms
#4
Lavanya B Achanta, Caroline D Rae
β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its contribution to energy metabolism in the healthy brain is minimal, it is an interesting metabolite which is not only oxidised but also has other direct and collateral effects which make it a molecule of interest for therapeutic purposes. In brain βOHB can be produced in astrocytes from oxidation of fatty acids or catabolism of amino acids and is metabolised in the mitochondria of all brain cell types although uptake across the blood brain barrier is a metabolic control point...
November 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27802904/panobinostat-induces-apoptosis-via-production-of-reactive-oxygen-species-and-synergizes-with-topoisomerase-inhibitors-in-cervical-cancer-cells
#5
Lubna Wasim, Madhu Chopra
Cervical cancer is the fourth major cause of cancer-related deaths in women worldwide and is the most common cancer in developing countries. Therefore, a search for novel treatment modalities is warranted. The present study is designed to investigate the effect of pan histone deacetylase inhibitor, 'panobinostat', on cervical cancer cells alone and in combination with topoisomerase inhibitors. We assessed the effect of panobinostat on two cervical cancer cell lines, HeLa and SiHa, for cell viability, apoptosis, oxidative stress and mitochondrial function using various assays...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27754271/sy-17-1-dynamic-regulation-of-redox-regulating-factor-ape1-ref-1-on-the-oxidative-stress-and-vascular-inflammation
#6
Byeong Hwa Jeon
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 is essential for cellular survival and embryonic lethal in knockout mouse models. Heterozygous APE1/Ref-1 mice showed impaired endothelium-dependent vasorelaxation, reduced vascular NO levels, and are hypertensive. APE1/Ref-1 reduces intracellular reactive oxygen species production by negatively regulating the activity of the NADPH oxidase...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27686535/function-of-the-sirt3-mitochondrial-deacetylase-in-cellular-physiology-cancer-and-neurodegenerative-disease
#7
Aneesa Ansari, Md Shahedur Rahman, Subbroto K Saha, Forhad K Saikot, Akash Deep, Ki-Hyun Kim
In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members, SIRT3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance. SIRT3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes...
September 29, 2016: Aging Cell
https://www.readbyqxmd.com/read/27643268/sy-17-1-dynamic-regulation-of-redox-regulating-factor-ape1-ref-1-on-the-oxidative-stress-and-vascular-inflammation
#8
Byeong Hwa Jeon
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 is essential for cellular survival and embryonic lethal in knockout mouse models. Heterozygous APE1/Ref-1 mice showed impaired endothelium-dependent vasorelaxation, reduced vascular NO levels, and are hypertensive. APE1/Ref-1 reduces intracellular reactive oxygen species production by negatively regulating the activity of the NADPH oxidase...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633396/silencing-of-histone-deacetylase-9-expression-in-podocytes-attenuates-kidney-injury-in-diabetic-nephropathy
#9
Feng Liu, Ming Zong, Xiaofei Wen, Xuezhu Li, Jun Wang, Yi Wang, Wei Jiang, Xiaojun Li, Zhongliang Guo, Hualin Qi
Podocyte dysfunction is important in the onset and development of diabetic nephropathy (DN). Histone deacetylases (HDACs) have been recently proved to play critical roles in the pathogenesis of DN. As one subtype of the class IIa HDACs, HDAC9 is capable to repress/de-repress their target genes in tumor, inflammation, atherosclerosis and metabolic diseases. In the present study, we investigate whether HDAC9 is involved in the pathophysiologic process of DN, especially the podocyte injury. Firstly, we explored the expression patterns and localization of HDAC9 and found that HDAC9 expression was significantly up-regulated in high glucose (HG)-treated mouse podocytes, as well as kidney tissues from diabetic db/db mice and patients with DN...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27624060/the-effects-of-molecular-hydrogen-and-suberoylanilide-hydroxamic-acid-on-paraquat-induced-production-of-reactive-oxygen-species-and-tnf-%C3%AE-in-macrophages
#10
Jiaoyang Li, Xizi Wu, Yao Chen, Renqing Zeng, Yangzi Zhao, Panpan Chang, Danna Wang, Qianwen Zhao, Yunlei Deng, Yongqing Li, Hasan B Alam, Wei Chong
The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) in macrophages. First, the PQ optimal concentration was determined in RAW264.7 macrophage by treating serum-starved cells with PQ at 0, 0.001, 0.01, 0.1, 1, and 10 mM. We evaluated at 1, 2 and 8 h (1) cell viability (by means of trypan blue exclusion method), (2) intracellular ROS levels (with a fluorescent DCFH-DA probe), and (3) TNF-α level in the culture media (determined by enzyme-linked immunosorbent assay, ELISA)...
December 2016: Inflammation
https://www.readbyqxmd.com/read/27578018/p66-shc-sirt1-regulation-of-oxidative-stress-protects-against-cardio-cerebral-vascular-disease
#11
Xiangyi Kong, Jian Guan, Jun Li, Junji Wei, Renzhi Wang
Growing evidence shows that acute and chronic overproduction of reactive oxygen species (ROS) and increased oxidants under pathophysiologic circumstances are of vital importance in the development of cardio-cerebral vascular diseases (CCVDs). It has been revealed that the impact of ROS can be suppressed by sirtuin 1 (SIRT1), a member of the highly conserved nicotinamide adenine dinucleotide-dependent class III histone deacetylases through protecting endothelial cells from oxidative injury. Plenty of evidences indicate that p66Shc stimulates mitochondrial ROS generation through its oxidoreductase activity and plays a vital role in the pathophysiology of CCVDs...
August 30, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27534902/sirtuin-6-suppresses-hypoxia-induced-inflammatory-response-in-human-osteoblasts-via-inhibition-of-reactive-oxygen-species-production-and-glycolysis-a-therapeutic-implication-in-inflammatory-bone-resorption
#12
Kuo-Liang Hou, Sze-Kwan Lin, Ling-Hsiu Chao, Eddie Hsiang-Hua Lai, Cheng-Chi Chang, Chia-Tung Shun, Wan-Yu Lu, Jyh-Horng Wang, Michael Hsiao, Chi-Yuan Hong, Sang-Heng Kok
Elevated glycolytic activity and redox imbalance induced by tissue hypoxia are common phenomena of chronic inflammation, including inflammatory bone diseases such as arthritis. However, relation between glycolysis and redox signaling in the inflammatory milieu is unclear. The histone deacetylase sirtuin 6 (SIRT6) is a crucial modulator of inflammation and glucose metabolism, and it is also involved in cellular protection against oxidative injury. The aims of the study were to examine the connection between glycolysis and reactive oxygen species (ROS) production in human osteoblastic cells (HOB) and whether SIRT6 modulates inflammatory response via regulation of glycolytic activity and ROS generation...
August 18, 2016: BioFactors
https://www.readbyqxmd.com/read/27498117/inhibition-of-histone-deacetylase-reduces-transcription-of-nadph-oxidases-and-ros-production-and-ameliorates-pulmonary-arterial-hypertension
#13
Feng Chen, Xueyi Li, Emily Aquadro, Stephen Haigh, Jiliang Zhou, David W Stepp, Neal L Weintraub, Scott A Barman, David J R Fulton
Excessive levels of reactive oxygen species (ROS) and increased expression of NADPH oxidases (Nox) have been proposed to contribute to pulmonary artery hypertension (PAH) and other cardiovascular diseases (CVD). Nox enzymes are major sources of ROS but the mechanisms regulating changes in Nox expression in disease states remain poorly understood. Epigenetics encompasses a number of mechanisms that cells employ to regulate the ability to read and transcribe DNA. Histone acetylation is a prominent example of an epigenetic mechanism regulating the expression of numerous genes by altering chromatin accessibility...
October 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27423454/histone-deacetylase-inhibitor-induces-cell-apoptosis-and-cycle-arrest-in-lung-cancer-cells-via-mitochondrial-injury-and-p53-up-acetylation
#14
Lianmin Bao, Hua Diao, Nian Dong, Xiaoqiong Su, Bingbin Wang, Qiongya Mo, Heguo Yu, Xiangdong Wang, Chengshui Chen
The reversibility of non-genotoxic phenotypic changes has been explored in order to develop novel preventive and therapeutic approaches for cancer. Quisinostat (JNJ-26481585), a novel second-generation histone deacetylase inhibitor (HDACi), has efficient therapeutic actions on non-small cell lung cancer (NSCLC) cell. The present study aims at investigating underlying molecular mechanisms involved in the therapeutic activity of quisinostat on NSCLC cells. We found that quisinostat significantly inhibited A549 cell proliferation in dose- and time-dependent manners...
December 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27381264/valproic-acid-exposure-decreases-cbp-p300-protein-expression-and-histone-acetyltransferase-activity-in-p19-cells
#15
Christina L Lamparter, Louise M Winn
The teratogenicity of the antiepileptic drug valproic acid (VPA) is well established and its inhibition of histone deacetylases (HDAC) is proposed as an initiating factor. Recently, VPA-mediated HDAC inhibition was demonstrated to involve transcriptional downregulation of histone acetyltransferases (HATs), which was proposed to compensate for the increased acetylation resulting from HDAC inhibition. Cbp and p300 are HATs required for embryonic development and deficiencies in either are associated with congenital malformations and embryolethality...
September 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27342760/regulation-of-oligodendrocyte-differentiation-insights-and-approaches-for-the-management-of-neurodegenerative-disease
#16
REVIEW
Abdullah Mohammad Tauheed, Joseph Olusegun Ayo, Mohammed Umaru Kawu
The development and maturation of oligodendrocyte require complex mechanisms that interact at different levels to regulate neuronal activities. This review examines specific functions and critical roles of oligodendrocyte, regulatory factors involved in its differentiation, including the involvement of glutamate and reactive oxygen species (ROS). Olig2, Id4, Wnt/β-catenin and histone deacetylase (HDAC) appear to play crucial roles in spatio-temporal regulation of the differentiation of oligodendrocytes. Furthermore, HDAC appears to be the rate-limiting factor that may be manipulated to promote myelination as it simultaneously allays contact inhibition of Id4 in the intrinsic pathway and Wnt/β-catenin in the extrinsic pathway...
September 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/27159442/mir-124-regulates-amadori-glycated-albumin-induced-retinal-microglial-activation-and-inflammation-by-targeting-rac1
#17
Ning Dong, Bing Xu, Hong Shi, Yan Lu
PURPOSE: To characterize whether the activation of Rac1 is involved in the inflammatory effects produced by Amadori-glycated albumin (AGA) in retinal microglia and to further explore the pathologic pathways of AGA-induced retinal microglial activation and inflammation via a microRNA-dependent mechanism. METHODS: Primary rat retinal microglia were separated and cultured. The levels of TNF-α mRNA and soluble TNF-α produced by the retinal microglia in response to AGA were measured with quantitative RT-PCR (qRT-PCR) and ELISA...
May 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27108737/low-dose-spiruchostatin-b-a-potent-histone-deacetylase-inhibitor-enhances-radiation-induced-apoptosis-in-human-lymphoma-u937-cells-via-modulation-of-redox-signaling
#18
Mati Ur Rehman, Paras Jawaid, Qing Li Zhao, Peng Li, Koichi Narita, Tadashi Katoh, Tadamichi Shimizu, Takashi Kondo
Spiruchostatin B (SP-B), is a potent histone deacetylase (HDAC) inhibitor, in addition to HDAC inhibition, the pharmacological effects of SP-B are also attributed to its ability to produce intracellular reactive oxygen species (ROS), particularly H2O2. In this study, we investigated the effects of low dose (non-toxic) SP-B on radiation-induced apoptosis in human lymphoma U937 cells in vitro. The treatment of cells with low-dose SP-B induced the acetylation of histones, however, does not induce apoptosis. Whereas, the combined treatment with SP-B and radiation significantly enhanced the radiation-induced apoptosis, suggesting the potential role of this combined treatment for future radiation therapy...
June 2016: Free Radical Research
https://www.readbyqxmd.com/read/27078845/histone-deacetylase-inhibitor-induced-cancer-stem-cells-exhibit-high-pentose-phosphate-pathway-metabolism
#19
Bisrat G Debeb, Lara Lacerda, Richard Larson, Adam R Wolfe, Savitri Krishnamurthy, James M Reuben, Naoto T Ueno, Michael Gilcrease, Wendy A Woodward
PURPOSE: We recently demonstrated that histone deacetylase (HDAC) inhibitors can "reprogram" differentiated triple-negative breast cancer cells to become quiescent stem-like cancer cells. We hypothesized that the metabolic state of such cells differs from that of their differentiated progeny. RESULTS: In untreated cells, glucose uptake was higher in ALDH+ cells than in ALDH- cells (p = 0.01) but lactate production was not different; treating ALDH- or ALDH+ cells with VA or SAHA similarly increased glucose uptake without changing lactate production but upregulated G6PD, a rate-limiting enzyme in pentose phosphate pathway metabolism...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27074555/therapeutic-potential-and-functional-interaction-of-carfilzomib-and-vorinostat-in-t-cell-leukemia-lymphoma
#20
Minjie Gao, Gege Chen, Houcai Wang, Bingqian Xie, Liangning Hu, Yuanyuan Kong, Guang Yang, Yi Tao, Ying Han, Xiaosong Wu, Yiwen Zhang, Bojie Dai, Jumei Shi
We previously showed that the proteasome inhibitor carfilzomib and the histone deacetylase inhibitor (HDACI) vorinostat cooperated to induce cell apoptosis in one T-cell leukemia cell line in vitro, implying the possibility of the combination treatment of carfilzomib and vorinostat as a potential therapeutic strategy in human T-cell leukemia/lymphoma. Here we report that combination treatment of carfilzomib and vorinostat enhanced cell apoptosis and induced a marked increase in G2-M arrest, reactive oxygen species (ROS) generation, and activated the members of mitogen-activated protein kinases (MAPK) family, including the stress-activated kinases JNK, p38MAPK, and ERK1/2...
May 17, 2016: Oncotarget
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