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histone deacetylase macrophage

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https://www.readbyqxmd.com/read/29734115/transcriptional-and-posttranscriptional-repression-of-histone-deacetylases-by-docosahexaenoic-acid-in-macrophages
#1
Tho X Pham, Minkyung Bae, Yoojin Lee, Young-Ki Park, Ji-Young Lee
Histone deacetylation is one of the posttranslational modifications of histones by which eukaryotic cells alter gene transcription. Although fatty acids are the best known macronutrients that modulate gene expression in inflammatory pathways, it is unclear whether common fatty acids in diets can regulate the expression of histone deacetylases (HDACs) in macrophages. We determined the effects of fatty acids, including palmitic acid (PA), oleic acid (OA), linoleic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the expression of HDAC isoforms in RAW 264...
March 10, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29700327/class-i-histone-deacetylase-hdac-inhibitor-ci-994-promotes-functional-recovery-following-spinal-cord-injury
#2
Suxiang Zhang, Yuki Fujita, Rieko Matsuzaki, Toshihide Yamashita
Spinal cord injury (SCI) induces severe and long-lasting neurological disability. Accumulating evidence has suggested that histone deacetylase (HDAC) inhibitors exert neuroprotective effects against various insults and deficits in the central nervous system. In the present study, we assessed the effect of the class I HDAC inhibitor CI-994 in a mouse model of SCI. Following SCI, mice were treated with either dimethyl sulfoxide (control vehicle) or 1, 10, or 30 mg/kg CI-994. Level of acetylated histone H3 expression was increased in the motor cortex and spinal cord of 10 mg/kg CCI-994-treated mice after SCI...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29680681/hdac-inhibition-helps-post-mi-healing-by-modulating-macrophage-polarization
#3
Denise Kimbrough, Sabina H Wang, Lillianne H Wright, Santhosh K Mani, Harinath Kasiganesan, Amanda C LaRue, Qi Cheng, Satish N Nadig, Carl Atkinson, Donald R Menick
AIMS: Following an acute myocardial infarction (MI) the extracellular matrix (ECM) undergoes remodeling in order to prevent dilation of the infarct area and maintain cardiac output. Excessive and prolonged inflammation following an MI exacerbates adverse ventricular remodeling. Macrophages are an integral part of the inflammatory response that contribute to this remodeling. Treatment with histone deacetylase (HDAC) inhibitors preserves LV function and myocardial remodeling in the post-MI heart...
April 19, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29645094/leishmania-amazonensis-downregulates-macrophage-inos-expression-via-histone-deacetylase-1-hdac1-a-novel-parasite-evasion-mechanism
#4
Teresa C Calegari-Silva, Áislan C Vivarini, Renata de M S Pereira, Karina L Dias-Teixeira, Carolina T Rath, Amanda S S Pacheco, Gabrielle B L Silva, Charlene A S Pinto, José V Dos Santos, Alessandra M Saliba, Carlos E P Corbett, Claudia M de Castro Gomes, Nicolas Fasel, Ulisses G Lopes
The induced expression of nitric oxide synthase (iNOS) controls the intracellular growth of Leishmania in infected macrophages. Histones deacetylases (HDACs) negatively regulate gene expression through the formation of complexes containing transcription factors such as NF-κB p50/50. Herein, we demonstrated the occupancy of p50/p50_HDAC1 to iNOS promoter associated with reduced levels of H3K9Ac. Remarkably, we found increased levels of HDAC1 in L. amazonensis-infected macrophages. HDAC1 upregulation was not found in L...
April 12, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29622848/the-hdac-inhibitor-saha-prevents-colonic-inflammation-by-suppressing-pro-inflammatory-cytokines-and-chemokines-in-dss-induced-colitis
#5
Mohmand Noor Ali, Narantsog Choijookhuu, Hideaki Takagi, Naparee Srisowanna, Mai Nguyen Nhat Huynh, Yuya Yamaguchi, Phyu Synn Oo, Myat Tin Htwe Kyaw, Katsuaki Sato, Ryoji Yamaguchi, Yoshitaka Hishikawa
Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract that is caused by multiple factors, including dysfunction of the immune system and genetic and epigenetic alterations. Aberrant epigenetic regulation, especially histone acetylation, was found in biopsies from IBD patients and mouse models of colitis, suggesting that an epigenetic treatment approach may be useful for IBD therapy. Therefore, we investigated the effects of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), in a mouse model of dextran sulfate sodium (DSS)-induced colitis...
February 27, 2018: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/29581526/hdac-genes-play-distinct-and-redundant-roles-in-cryptococcus-neoformans-virulence
#6
Fabiana Brandão, Shannon K Esher, Kyla S Ost, Kaila Pianalto, Connie B Nichols, Larissa Fernandes, Anamélia L Bocca, Marcio José Poças-Fonseca, J Andrew Alspaugh
The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host. To explore the role of chromatin remodeling on the expression of virulence-related traits, we identified and deleted seven genes encoding predicted class I/II histone deacetylases (HDACs) in the C. neoformans genome. These studies demonstrated that individual HDACs control non-identical but overlapping cellular processes associated with virulence, including thermotolerance, capsule formation, melanin synthesis, protease activity and cell wall integrity...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29574768/histone-methylation-and-acetylation-in-macrophages-as-a-mechanism-for-regulation-of-inflammatory-responses
#7
REVIEW
Maria G Daskalaki, Christos Tsatsanis, Sotirios C Kampranis
Macrophages respond to noxious stimuli and contribute to inflammatory responses by eliminating pathogens or damaged tissue and maintaining homeostasis. Response to activation signals and maintenance of homeostasis require tight regulation of genes involved in macrophage activation and inactivation processes, as well as genes involved in determining their polarization state. Recent evidence has revealed that such regulation occurs through histone modifications that render inflammatory or polarizing gene promoters accessible to transcriptional complexes...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29567326/lysine-deacetylases-and-regulated-glycolysis-in-macrophages
#8
REVIEW
Melanie R Shakespear, Abishek Iyer, Catherine Youting Cheng, Kaustav Das Gupta, Amit Singhal, David P Fairlie, Matthew J Sweet
Regulated cellular metabolism has emerged as a fundamental process controlling macrophage functions, but there is still much to uncover about the precise signaling mechanisms involved. Lysine acetylation regulates the activity, stability, and/or localization of metabolic enzymes, as well as inflammatory responses, in macrophages. Two protein families, the classical zinc-dependent histone deacetylases (HDACs) and the NAD-dependent HDACs (sirtuins, SIRTs), mediate lysine deacetylation. We describe here mechanisms by which classical HDACs and SIRTs directly regulate specific glycolytic enzymes, as well as evidence that links these protein deacetylases to the regulation of glycolysis-related genes...
March 19, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29548672/histone-deacetylases-1-and-2-regulate-microglia-function-during-development-homeostasis-and-neurodegeneration-in-a-context-dependent-manner
#9
Moumita Datta, Ori Staszewski, Elena Raschi, Maximilian Frosch, Nora Hagemeyer, Tuan Leng Tay, Thomas Blank, Mario Kreutzfeldt, Doron Merkler, Stephanie Ziegler-Waldkirch, Patrick Matthias, Melanie Meyer-Luehmann, Marco Prinz
Microglia as tissue macrophages contribute to the defense and maintenance of central nervous system (CNS) homeostasis. Little is known about the epigenetic signals controlling microglia function in vivo. We employed constitutive and inducible mutagenesis in microglia to delete two class I histone deacetylases, Hdac1 and Hdac2. Prenatal ablation of Hdac1 and Hdac2 impaired microglial development. Mechanistically, the promoters of pro-apoptotic and cell cycle genes were hyperacetylated in absence of Hdac1 and Hdac2, leading to increased apoptosis and reduced survival...
March 20, 2018: Immunity
https://www.readbyqxmd.com/read/29523311/mycobacterium-tuberculosis-infection-induces-il-10-gene-expression-by-disturbing-histone-deacetylase-6-and-histonedeacetylase-11-equilibrium-in-macrophages
#10
Xiaolei Wang, Yanhua Wu, Jin Jiao, Qing Huang
Mycobacterium tuberculosis (MTB) infection is a significant contributor to dysregulated T cell-mediated immune response. Here we aimed to evaluate the mechanism of MTB infection in promoting interleukin-10 (IL-10) upregulation. The IL-10 levels in MTB infected THP-1 cells were evaluated with enzyme-linked immunosorbent assay (ELISA) and quantitative real-time PCR (qRT-PCR). In challenged THP-1 cells, the HDAC6 and HDAC11 mRNA and protein levels were monitored at varied duration after MTB infection. Further, chromatin immunoprecipitation (ChIP) analysis was used to investigate the interaction between IL-10 expression and HDAC6 or HDAC11...
January 2018: Tuberculosis
https://www.readbyqxmd.com/read/29501835/evaluation-of-the-efficacy-of-valproic-acid-and-suberoylanilide-hydroxamic-acid-vorinostat-in-enhancing-the-effects-of-first-line-tuberculosis-drugs-against-intracellular-mycobacterium-tuberculosis
#11
Martin Rao, Davide Valentini, Alimuddin Zumla, Markus Maeurer
BACKGROUND: New tuberculosis (TB) drug treatment regimens are urgently needed. This study evaluated the potential of the histone deacetylase inhibitors (HDIs) valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) to enhance the effects of first-line anti-TB drugs against intracellular Mycobacterium tuberculosis. METHODS: M. tuberculosis H37Rv cultures were exposed to VPA or SAHA over 6 days, in the presence or absence of isoniazid (INH) and rifampicin (RIF)...
April 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29497113/tolerance-of-chronic-hdaci-treatment-for-neurological-visceral-and-lung-niemann-pick-type-c-disease-in-mice
#12
Md Suhail Alam, Bruce Cooper, Joseph D Farris, Kasturi Haldar
Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use to treat neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo), 2-hydroxypropyl-beta-cyclodextrin (HPBCD) and polyethylene glycol (PEG) 400 improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1 nmf164 murine model of Niemann-Pick Type C (NPC) disease...
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29464055/-neratinib-valproate-exposure-permanently-reduces-erbb1-and-ras-expression-in-4t1-mammary-tumors-and-enhances-m1-macrophage-infiltration
#13
Laurence Booth, Jane L Roberts, Rumeesa Rais, John Kirkwood, Francesca Avogadri-Connors, Richard E Cutler, Alshad S Lalani, Andrew Poklepovic, Paul Dent
The irreversible ERBB1/2/4 inhibitor neratinib has been shown in vitro to rapidly reduce the expression of ERBB1/2/4 and RAS proteins via autophagic/lysosomal degradation. We have recently demonstrated that neratinib and valproate interact to suppress the growth of 4T1 mammary tumors but had not defined whether the [neratinib + valproate] drug combination, in a mouse, had altered the biology of the 4T1 cells. Exposure of 4T1 mammary tumors to [neratinib + valproate] for three days resulted, two weeks later, in tumors that expressed less ERBB1, K-RAS, N-RAS, indoleamine-pyrrole 2,3-dioxygenase (IDO-1), ornithine decarboxylase (ODC) and had increased Class I MHCA expression...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29432557/epigenetic-modifiers-as-new-immunomodulatory-therapies-in-solid-tumours
#14
S Aspeslagh, D Morel, J-C Soria, S Postel-Vinay
Background: Immune therapies have revolutionized cancer treatment over the last few years by allowing improvements in overall survival. However, the majority of patients is still primary or secondary resistant to such therapies, and enhancing sensitivity to immune therapies is therefore crucial to improve patient outcome. Several recent lines of evidence suggest that epigenetic modifiers have intrinsic immunomodulatory properties, which could be of therapeutic interest. Material and methods: We reviewed preclinical evidence and clinical studies which describe or exploit immunomodulatory properties of epigenetic agents...
April 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29344006/histone-deacetylase-2-hdac2-attenuates-lipopolysaccharide-lps-induced-inflammation-by-regulating-pai-1-expression
#15
Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang, Meng-Chih Lin
Background: Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we developed an effective adjunct therapy mediated by a novel mechanism, to attenuate overt inflammation. LPS-treated macrophages were adopted as an in vitro model of endotoxin-induced inflammation during sepsis. Experiments were carried out using primary mouse peritoneal macrophages and the murine macrophage cell line RAW264...
2018: Journal of Inflammation
https://www.readbyqxmd.com/read/29343087/sulfhydrated-sirtuin-1-increasing-its-deacetylation-activity-is-an-essential-epigenetics-mechanism-of-anti-atherogenesis-by-hydrogen-sulfide
#16
Congkuo Du, Xianjuan Lin, Wenjing Xu, Fengjiao Zheng, Junyan Cai, Jichun Yang, Qinghua Cui, Chaoshu Tang, Jun Cai, Guoheng Xu, Bin Geng
AIMS: Hydrogen sulfide (H2S) has a protective role in the pathogenesis of atherosclerosis by multiple pathways. Sirtuin-1 (SIRT1) is a histone deacetylase, as an essential mediated longevity gene, and has an anti-atherogenic effect by regulating the acetylation of some functional proteins. Whether SIRT1 is involved in protecting H2S in atherosclerosis and its mechanism remains unclear. RESULTS: In ApoE-knockout atherosclerosis mice, treatment with an H2S donor (NaHS or GYY4137) reduced atherosclerotic plaque area, macrophage infiltration, aortic inflammation and plasma lipid level...
January 17, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29242252/correction-for-mounce-et-al-a-conserved-gammaherpesvirus-protein-kinase-targets-histone-deacetylases-1-and-2-to-facilitate-viral-replication-in-primary-macrophages
#17
Bryan C Mounce, Wadzanai P Mboko, Tarin M Bigley, Scott S Terhune, Vera L Tarakanova
No abstract text is available yet for this article.
January 1, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29238349/the-roles-of-glycodelin-in-cancer-development-and-progression
#18
REVIEW
Juan Cui, Yanguo Liu, Xiuwen Wang
Glycodelin is a kind of glycoprotein expressed in secretory endometrium, pregnancy deciduas, and amniotic fluid originally, which is vital for the maintenance of normal human reproductive activities. Recent researches have reported that glycodelin is specifically expressed in various malignancies, including female-specific cancers such as endometrial cancer, ovarian cancer and breast cancer, and non-gender specific cancers including lung cancer, and colon cancer, and glycodelin expression correlates with the diagnosis and prognosis of cancer patients...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29207042/anti-inflammatory-effect-of-lovastatin-is-mediated-via-the-modulation-of-nf-%C3%AE%C2%BAb-and-inhibition-of-hdac1-and-the-pi3k-akt-mtor-pathway-in-raw264-7-macrophages
#19
Hyung-Wook Choi, Pyung-Gyun Shin, Ji-Hyun Lee, Woo-Suk Choi, Min-Jae Kang, Won-Sik Kong, Min-Ji Oh, Yong-Bae Seo, Gun-Do Kim
Lovastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor that is clinically used for the prevention of cardiovascular diseases. Although it has been reported that lovastatin has anti-inflammatory properties in several studies, how lovastatin regulates the inflammation is still unclear. To evaluate the effect of lovastatin on nitric oxide production (NO) in RAW264.7 macrophages, NO production assay was performed. Also, cell viability was measured to confirm cytotoxicity. Level of tumor necrosis factor-α (TNF-α) transcription was measured by reverse transcription polymerase chain reaction (RT-PCR) from total RNA in RAW264...
February 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29203668/epigenetic-therapy-activates-type-i-interferon-signaling-in-murine-ovarian-cancer-to-reduce-immunosuppression-and-tumor-burden
#20
Meredith L Stone, Katherine B Chiappinelli, Huili Li, Lauren M Murphy, Meghan E Travers, Michael J Topper, Dimitrios Mathios, Michael Lim, Ie-Ming Shih, Tian-Li Wang, Chien-Fu Hung, Vipul Bhargava, Karla R Wiehagen, Glenn S Cowley, Kurtis E Bachman, Reiner Strick, Pamela L Strissel, Stephen B Baylin, Cynthia A Zahnow
Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an immune suppressive microenvironment, and response of ovarian cancers to immune therapies has thus far been disappointing. We now find, in a mouse model of EOC, that clinically relevant doses of DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi, respectively) reduce the immune suppressive microenvironment through type I IFN signaling and improve response to immune checkpoint therapy...
December 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
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