Huiyan Ma, Libo Yang, Yajuan Liu, Ru Yan, Rui Wang, Peng Zhang, Zhixia Bai, Yuanyuan Liu, Yi Ren, Yiwei Li, Xin Jiang, Ting Wang, Ping Ma, Qining Zhang, Aifei Li, Mixue Guo, Xiaoxia Zhang, Shaobin Jia, Hao Wang
Chronic low-grade inflammation is regarded to an important signature of atherosclerosis (AS). Macrophage (Mψ) and related polarization have been demonstrated to play a crucial role in the occurrence and development of AS inflammation. Butyrate, a bioactive molecule produced by the intestinal flora, has been increasingly demonstrated to exhibit a vital role for regulating the inflammation in chronic metabolic diseases. However, the effectiveness and multiple anti-inflammation mechanisms of butyrate on AS still need to be further understood...
2023: PloS One