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histone deacetylase adipose

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https://www.readbyqxmd.com/read/27900262/impaired-histone-deacetylases-5-and-6-expression-mimics-the-effects-of-obesity-and-hypoxia-on-adipocyte-function
#1
Julien Bricambert, Dimitri Favre, Saška Brajkovic, Amélie Bonnefond, Raphael Boutry, Roberto Salvi, Valérie Plaisance, Mohamed Chikri, Giulia Chinetti-Gbaguidi, Bart Staels, Vittorio Giusti, Robert Caiazzo, François Pattou, Gérard Waeber, Philippe Froguel, Amar Abderrahmani
OBJECTIVE: The goal of the study was to investigate the role of histone deacetylases (HDACs) in adipocyte function associated with obesity and hypoxia. METHODS: Total proteins and RNA were prepared from human visceral adipose tissues (VAT) of human obese and normal weight subjects and from white adipose tissue (WAT) of C57Bl6-Rj mice fed a normal or high fat diet (HFD) for 16 weeks. HDAC activity was measured by colorimetric assay whereas the gene and protein expression were monitored by real-time PCR and by western blotting, respectively...
December 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27875543/irisin-ameliorates-hypoxia-reoxygenation-induced-injury-through-modulation-of-histone-deacetylase-4
#2
Yu Tina Zhao, Hao Wang, Shouyan Zhang, Jianfeng Du, Shougang Zhuang, Ting C Zhao
Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissues. However, its effects in the heart remains unknown. This study sought to determine the effects of irisin on hypoxia/reoxygenation injury and its relationship with HDAC4. Wild type and stable HDAC4-overexpression cells were generated from H9c2 cardiomyoblasts. HDAC4 overexpression cells and wild type H9c2 cells were exposed to 24 hours of hypoxia followed by one hour of reoxygenation in vitro in the presence or absence of irisin (5 ng/ml)...
2016: PloS One
https://www.readbyqxmd.com/read/27861911/metabolism-of-ketone-bodies-during-exercise-and-training-physiological-basis-for-exogenous-supplementation
#3
Mark Evans, Karl E Cogan, Brendan Egan
Optimising training and performance through nutrition strategies is central to supporting elite sportspeople, much of which has focussed on manipulating the relative intake of carbohydrate and fat and their contributions as fuels for energy provision. The ketone bodies, namely acetoacetate, acetone, and β-hydroxybutyrate (βHB), are produced in the liver during conditions of reduced carbohydrate availability and serve as an alternative fuel source for peripheral tissues including brain, heart and skeletal muscle...
November 10, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27819724/histone-h3k9-acetylation-influences-growth-characteristics-of-goat-adipose-derived-stem-cells-in-vitro
#4
X Wang, F X Zhang, Z M Wang, Q Wang, H F Wang, Y Ren, D P Tai, H Liang, D J Liu
Adipose-derived stem cells (ADSCs) show nearly unlimited potential in medical and animal science. Currently, understanding of the biological mechanisms regulating ADSC growth in vitro remains very limited. Histone acetylation, an epigenetic modification, plays a key role in maintaining stem cell properties. To further study its effect on ADSC growth characteristics in vitro, we treated goat ADSCs with the histone deacetylase inhibitors trichostatin A (TSA) and vorinostat (SAHA). This inhibited SIRT1 expression and increased histone H3K9 acetylation, leading to decreased cell viability, cell cycle arrest, and apoptosis...
November 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27807598/salt-inducible-kinase-2-and-3-are-downregulated-in-adipose-tissue-from-obese-or-insulin-resistant-individuals-implications-for-insulin-signalling-and-glucose-uptake-in-human-adipocytes
#5
Johanna Säll, Annie M L Pettersson, Christel Björk, Emma Henriksson, Sebastian Wasserstrom, Wilhelm Linder, Yuedan Zhou, Ola Hansson, Daniel P Andersson, Mikael Ekelund, Eva Degerman, Karin G Stenkula, Jurga Laurencikiene, Olga Göransson
AIMS/HYPOTHESIS: Salt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). SIK2 is abundant in adipose tissue. The aims of this study were to investigate the expression of SIKs in relation to human obesity and insulin resistance, and to evaluate whether changes in the expression of SIKs might play a causal role in the development of disturbed glucose uptake in human adipocytes. METHODS: SIK mRNA and protein was determined in human adipose tissue or adipocytes, and correlated to clinical variables...
November 2, 2016: Diabetologia
https://www.readbyqxmd.com/read/27795551/attenuation-of-diet-induced-obesity-and-induction-of-white-fat-browning-with-a-chemical-inhibitor-of-histone-deacetylases
#6
A Ferrari, E Fiorino, R Longo, S Barilla, N Mitro, G Cermenati, M Giudici, D Caruso, A Mai, U Guerrini, E De Fabiani, M Crestani
BACKGROUND/OBJECTIVES: In the last decade a strict link between epigenetics and metabolism has been demonstrated. Histone deacetylases (HDACs) have emerged as key epigenetic regulators involved in metabolic homeostasis in normal and pathologic conditions. Here we investigated the effect of the class I HDAC inhibitor MS-275 in a model of obesity induced by a high fat diet (HFD). METHODS: C57BL6/J male mice were fed HFD for 17 weeks and then randomized in two groups treated intraperitoneally with vehicle (DMSO) or with the class I selective HDAC inhibitor MS-275 every other day for 22 days...
October 31, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27270450/sodium-butyrate-reduces-insulin-resistance-fat-accumulation-and-dyslipidemia-in-type-2-diabetic-rat-a-comparative-study-with-metformin
#7
Sabbir Khan, Gopabandhu Jena
Recent evidences highlighted that histone deacetylases (HDACs) can deacetylate the histone, various transcription factors and regulatory proteins, which directly or indirectly affect glucose metabolism. The present study aimed to evaluate the comparative effects of sodium butyrate (NaB) and metformin on the glucose homeostasis, insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat. Diabetes was developed in Sprague-Dawley rats by the combination of high-fat diet (HFD) and low dose streptozotocin (STZ, 35 mg/kg)...
July 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27247940/a-drosophila-model-for-screening-antiobesity-agents
#8
Tran Thanh Men, Duong Ngoc Van Thanh, Masamitsu Yamaguchi, Takayoshi Suzuki, Gen Hattori, Masayuki Arii, Nguyen Tien Huy, Kaeko Kamei
Although triacylglycerol, the major component for lipid storage, is essential for normal physiology, its excessive accumulation causes obesity in adipose tissue and is associated with organ dysfunction in nonadipose tissue. Here, we focused on the Drosophila model to develop therapeutics for preventing obesity. The brummer (bmm) gene in Drosophila melanogaster is known to be homologous with human adipocyte triglyceride lipase, which is related to the regulation of lipid storage. We established a Drosophila model for monitoring bmm expression by introducing the green fluorescent protein (GFP) gene as a downstream reporter of the bmm promoter...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26944797/valproic-acid-reduces-insulin-resistance-fat-deposition-and-foxo1-mediated-gluconeogenesis-in-type-2-diabetic-rat
#9
Sabbir Khan, Sandeep Kumar, Gopabandhu Jena
Recent evidences highlighted the role of histone deacetylases (HDACs) in insulin-resistance, gluconeogenesis and islet function. HDACs can modulate the expression of various genes, which directly or indirectly affect glucose metabolism. This study was aimed to evaluate the role of valproic acid (VPA) on fat deposition, insulin-resistance and gluconeogenesis in type-2 diabetic rat. Diabetes was developed in Sprague-Dawley rats by the combination of high-fat diet and low dose streptozotocin. VPA at the doses of 150 and 300 mg/kg/day and metformin (positive control) 150 mg/kg twice daily for 10 weeks were administered by oral gavage...
June 2016: Biochimie
https://www.readbyqxmd.com/read/26872126/macrophage-cgi-58-attenuates-inflammatory-responsiveness-via-promotion-of-ppar%C3%AE-signaling
#10
Dan Yang, Haimei Chen, Xu Zeng, Ping Xie, Xincun Wang, Chang Liu
BACKGROUND/AIMS: Comparative gene identification-58 (CGI-58), an adipose triglyceride lipase (ATGL) coactivator, strongly promotes ATGL-mediated triglyceride (TG) catabolism. Beyond its function in promoting lipolysis, other features of CGI-58 have been proposed. Here, we investigated the role of CGI-58 in the regulation of inflammatory responsiveness in macrophages. METHODS: Macrophage-specific GCI-58 transgenic mice (TG) and wild type mice (WT) were fed a high fat diet (HFD), and RAW264...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26785315/programmed-hyperphagia-in-offspring-of-obese-dams-altered-expression-of-hypothalamic-nutrient-sensors-neurogenic-factors-and-epigenetic-modulators
#11
Mina Desai, Guang Han, Michael G Ross
Maternal overnutrition results in programmed offspring obesity, mediated in part, by hyperphagia. This is remarkably similar to the effects of maternal undernutrition on offspring hyperphagia and obesity. In view of the marked differences in the energy environment of the over and under-nutrition exposures, we studied the expression of select epigenetic modifiers associated with energy imbalance including neurogenic factors and appetite/satiety neuropeptides which are indicative of neurogenic differentiation...
April 1, 2016: Appetite
https://www.readbyqxmd.com/read/26733201/histone-deacetylase-1-hdac1-negatively-regulates-thermogenic-program-in-brown-adipocytes-via-coordinated-regulation-of-histone-h3-lysine-27-h3k27-deacetylation-and-methylation
#12
Fenfen Li, Rui Wu, Xin Cui, Lin Zha, Liqing Yu, Hang Shi, Bingzhong Xue
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces adiposity, and improves insulin sensitivity in obese mice. However, the precise mechanism is poorly understood. Here, we demonstrate that HDAC1 is a negative regulator of the brown adipocyte thermogenic program. The Hdac1 level is lower in mouse brown fat (BAT) than white fat, is suppressed in mouse BAT during cold exposure or β3-adrenergic stimulation, and is down-regulated during brown adipocyte differentiation. Remarkably, overexpressing Hdac1 profoundly blocks, whereas deleting Hdac1 significantly enhances, β-adrenergic activation-induced BAT-specific gene expression in brown adipocytes...
February 26, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26661466/chondrogenic-potential-and-anti-senescence-effect-of-hypoxia-on-canine-adipose-mesenchymal-stem-cells
#13
Jienny Lee, Jeong Su Byeon, Keum Sil Lee, Na-Yeon Gu, Gyeong Been Lee, Hee-Ryang Kim, In-Soo Cho, Sang-Ho Cha
Mesenchymal stem cells (MSCs) have the ability to differentiate into multi-lineage cells, which confers great promise for use in regenerative medicine. In this study, canine adipose MSCs (cAD-MSCs) were isolated from canine adipose tissue. These cells clearly represented stemness (Oct4, Sox2, and Nanog) and differentiation potential into the mesoderm (adipocytes, chondrocytes, and osteoblasts) at early passages. The aim of this study was to evaluate the effects of hypoxia on the differentiation potential into mesoderm, and the expression of anti-apoptotic genes associated with cell survival for the optimal culturing of MSCs...
March 2016: Veterinary Research Communications
https://www.readbyqxmd.com/read/26609312/the-combination-of-resveratrol-and-quercetin-attenuates-metabolic-syndrome-in-rats-by-modifying-the-serum-fatty-acid-composition-and-by-upregulating-sirt-1-and-sirt-2-expression-in-white-adipose-tissue
#14
Ana Elena Peredo-Escárcega, Verónica Guarner-Lans, Israel Pérez-Torres, Sergio Ortega-Ocampo, Elizabeth Carreón-Torres, Vicente Castrejón-Tellez, Eulises Díaz-Díaz, María Esther Rubio-Ruiz
Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS). These natural compounds upregulate and activate sirtuins (SIRTs), a family of NAD-dependent histone deacetylases. We analyzed the effect of two doses of a commercial combination of RSV and QRC on serum fatty acid composition and their regulation of SIRTs 1-3 and PPAR-γ expression in white adipose tissue. MetS was induced in Wistar rats by adding 30% sucrose to drinking water for five months...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26567565/molecular-mechanisms-of-latent-inflammation-in-metabolic-syndrome-possible-role-of-sirtuins-and-peroxisome-proliferator-activated-receptor-type-%C3%AE
#15
REVIEW
I S Stafeev, M Y Menshikov, Z I Tsokolaeva, M V Shestakova, Ye V Parfyonova
The problem of metabolic syndrome is one of the most important in medicine today. The main hazard of metabolic syndrome is development of latent inflammation in adipose tissue, which promotes atherosclerosis, non-alcoholic fatty liver disease, myocarditis, and a number of other illnesses. Therefore, understanding of molecular mechanisms of latent inflammation in adipose tissue is very important for treatment of metabolic syndrome. Three main components that arise during hypertrophy and hyperplasia of adipocytes underlie such inflammation: endoplasmic reticulum stress, oxidative stress, and hypoxia...
October 2015: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/26464423/preclinical-investigation-of-the-novel-histone-deacetylase-inhibitor-ar-42-in-the-treatment-of-cancer-induced-cachexia
#16
Yu-Chou Tseng, Samuel K Kulp, I-Lu Lai, En-Chi Hsu, Wei A He, David E Frankhouser, Pearlly S Yan, Xiaokui Mo, Mark Bloomston, Gregory B Lesinski, Guido Marcucci, Denis C Guttridge, Tanios Bekaii-Saab, Ching-Shih Chen
BACKGROUND: Cancer cachexia is a debilitating condition that impacts patient morbidity, mortality, and quality of life and for which effective therapies are lacking. The anticachectic activity of the novel HDAC inhibitor AR-42 was investigated in murine models of cancer cachexia. METHODS: The effects of AR-42 on classic features of cachexia were evaluated in the C-26 colon adenocarcinoma and Lewis lung carcinoma (LLC) models. Effects on survival in comparison with approved HDAC inhibitors (vorinostat, romidepsin) were determined...
December 2015: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26317058/role-of-histone-deacetylase-9-in-regulating-adipogenic-differentiation-and-high-fat-diet-induced-metabolic-disease
#17
Tapan K Chatterjee, Joshua E Basford, Kan Hui Yiew, David W Stepp, David Y Hui, Neal L Weintraub
Adipose tissue serves as both a storage site for excess calories and as an endocrine organ, secreting hormones such as adiponectin that promote metabolic homeostasis. In obesity, adipose tissue expands primarily by hypertrophy (enlargement of existing adipocytes) rather than hyperplasia (generation of new adipocytes via adipogenic differentiation of preadipocytes). Progressive adipocyte hypertrophy leads to inflammation, insulin resistance, dyslipidemia, and ectopic lipid deposition, the hallmark characteristics of metabolic disease...
October 2014: Adipocyte
https://www.readbyqxmd.com/read/26260473/a-72-hour-high-fat-diet-increases-transcript-levels-of-the-neuropeptide-galanin-in-the-dorsal-hippocampus-of-the-rat
#18
Ling Gan, Emily England, Jeong-Yeh Yang, Natalie Toulme, Suresh Ambati, Diane L Hartzell, Richard B Meagher, Clifton A Baile
BACKGROUND: Recent evidence identifies the hippocampus, a brain structure commonly associated with learning and memory, as key to the regulation of food intake and the development and consequences of obesity. Intake of a high fat diet (HFD) results in altered consumptive behavior, hippocampal damage, and cognitive deficits. While many studies report the effects of HFD after chronic consumption and in the instance of obesity, few examine the events that occur following acute HFD consumption...
2015: BMC Neuroscience
https://www.readbyqxmd.com/read/26236282/age-associated-weight-gain-leptin-and-sirt1-a-possible-role-for-hypothalamic-sirt1-in-the-prevention-of-weight-gain-and-aging-through-modulation-of-leptin-sensitivity
#19
REVIEW
Tsutomu Sasaki
The hypothalamus is the principal regulator of body weight and energy balance. It modulates both energy intake and energy expenditure by sensing the energy status of the body through neural inputs from the periphery as well as direct humoral inputs. Leptin, an adipokine, is one of the humoral factors responsible for alerting the hypothalamus that enough energy is stored in the periphery. Plasma leptin levels are positively linked to adiposity; leptin suppress energy intake and stimulates energy expenditure...
2015: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/26211746/hdac3-deficiency-increases-marrow-adiposity-and-induces-lipid-storage-and-glucocorticoid-metabolism-in-osteochondroprogenitor-cells
#20
Meghan E McGee-Lawrence, Lomeli R Carpio, Ryan J Schulze, Jessica L Pierce, Mark A McNiven, Joshua N Farr, Sundeep Khosla, Merry Jo Oursler, Jennifer J Westendorf
Bone loss and increased marrow adiposity are hallmarks of aging skeletons. Conditional deletion of histone deacetylase 3 (Hdac3) in murine osteochondroprogenitor cells causes osteopenia and increases marrow adiposity, even in young animals, but the origins of the increased adiposity are unclear. To explore this, bone marrow stromal cells (BMSCs) from Hdac3-depleted and control mice were cultured in osteogenic medium. Hdac3-deficient cultures accumulated lipid droplets in greater abundance than control cultures and expressed high levels of genes related to lipid storage (Fsp27/Cidec, Plin1) and glucocorticoid metabolism (Hsd11b1) despite normal levels of Pparγ2...
January 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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