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https://www.readbyqxmd.com/read/28813502/addressing-the-challenge-of-high-priced-prescription-drugs-in-the-era-of-precision-medicine-a-systematic-review-of-drug-life-cycles-therapeutic-drug-markets-and-regulatory-frameworks
#1
Toon van der Gronde, Carin A Uyl-de Groot, Toine Pieters
CONTEXT: Recent public outcry has highlighted the rising cost of prescription drugs worldwide, which in several disease areas outpaces other health care expenditures and results in a suboptimal global availability of essential medicines. METHOD: A systematic review of Pubmed, the Financial Times, the New York Times, the Wall Street Journal and the Guardian was performed to identify articles related to the pricing of medicines. FINDINGS: Changes in drug life cycles have dramatically affected patent medicine markets, which have long been considered a self-evident and self-sustainable source of income for highly profitable drug companies...
2017: PloS One
https://www.readbyqxmd.com/read/28813093/where-is-sugarcane-cropping-expanding-in-the-brazilian-cerrado-and-why-a-case-study
#2
Murilo R DE Arruda, Ken E Giller, Maja Slingerland
Sugarcane growing area in Brazil sharply expanded between 2000 and 2010 due to the increasing world demand for sugar and ethanol. Since this expansion of sugarcane is said to occur in areas covered by degraded pastures, it is likely not threatening the environment or food production. In order to verify this assumption, we investigate at farm and field levels which types of land use sugarcane cropping replaced between 2005 and 2010 and the reasons for farmers shifting or not shifting to sugarcane, as a case study in two counties in the state of Goiás...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28813028/detection-methodologies-for-pathogen-and-toxins-a-review
#3
REVIEW
Md Eshrat E Alahi, Subhas Chandra Mukhopadhyay
Pathogen and toxin-contaminated foods and beverages are a major source of illnesses, even death, and have a significant economic impact worldwide. Human health is always under a potential threat, including from biological warfare, due to these dangerous pathogens. The agricultural and food production chain consists of many steps such as harvesting, handling, processing, packaging, storage, distribution, preparation, and consumption. Each step is susceptible to threats of environmental contamination or failure to safeguard the processes...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28812228/e-commerce-review-system-to-detect-false-reviews
#4
Manjur Kolhar
E-commerce sites have been doing profitable business since their induction in high-speed and secured networks. Moreover, they continue to influence consumers through various methods. One of the most effective methods is the e-commerce review rating system, in which consumers provide review ratings for the products used. However, almost all e-commerce review rating systems are unable to provide cumulative review ratings. Furthermore, review ratings are influenced by positive and negative malicious feedback ratings, collectively called false reviews...
August 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28811152/how-does-media-coverage-effect-the-consumption-of-antidepressants-a-study-of-the-media-coverage-of-antidepressants-in-danish-online-newspapers-2010-2011
#5
Michael Green Lauridsen, Sofia Kälvemark Sporrong
BACKGROUND: The news media has become a major source of health information for the public, and hence vital in the individuals' opinions and decisions about health topics. The first decrease in the usage of antidepressants in Denmark in over a decade happened alongside an intensive period of media coverage about antidepressants. OBJECTIVES: The aim of this study was to examine the Danish media's coverage of antidepressants during 2010-2011 in order to explore what influence it could have had on the change in the use of antidepressants...
August 2, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28810834/multiple-trait-qtl-mapping-and-genomic-prediction-for-wool-traits-in-sheep
#6
Sunduimijid Bolormaa, Andrew A Swan, Daniel J Brown, Sue Hatcher, Nasir Moghaddar, Julius H van der Werf, Michael E Goddard, Hans D Daetwyler
BACKGROUND: The application of genomic selection to sheep breeding could lead to substantial increases in profitability of wool production due to the availability of accurate breeding values from single nucleotide polymorphism (SNP) data. Several key traits determine the value of wool and influence a sheep's susceptibility to fleece rot and fly strike. Our aim was to predict genomic estimated breeding values (GEBV) and to compare three methods of combining information across traits to map polymorphisms that affect these traits...
August 15, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28810219/industrial-hemp-as-a-potential-bioenergy-crop-in-comparison-with-kenaf-switchgrass-and-biomass-sorghum
#7
Lalitendu Das, Enshi Liu, Areej Saeed, David W Williams, Hongqiang Hu, Chenlin Li, Allison E Ray, Jian Shi
This study takes combined field trial, lab experiment, and economic analysis approaches to evaluate the potential of industrial hemp in comparison with kenaf, switchgrass and biomass sorghum. Agronomy data suggest that the per hectare yield (5437kg) of industrial hemp stem alone was at a similar level with switchgrass and sorghum; while the hemp plants require reduced inputs. Field trial also showed that ∼1230kg/ha hemp grain can be harvested in addition to stems. Results show a predicted ethanol yield of ∼82gallons/dry ton hemp stems, which is comparable to the other three tested feedstocks...
August 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28809590/brand-trust-and-image-effects-on-customer-satisfaction
#8
Sayed Hamid Khodadad Hosseini, Leila Behboudi
Purpose The purpose of this paper is to investigate brand trust and brand image effects on healthcare service users. Nowadays, managers and health activists are showing increased tendency to marketing and branding to attract and satisfy customers. Design/methodology/approach The current study's design is based on a conceptual model examining brand trust and brand image effects on customer satisfaction. Data obtained from 240 questionnaires (310 respondents) were analyzed using path analysis. Findings Results revealed that the most effective items bearing the highest influence on customer satisfaction and on benefiting from healthcare services include brand image, staff sincerity to its patients, interactions with physicians and rapport...
August 14, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28807704/palliative-care-albania
#9
Rudina Rama, Valbona Mane-Carcani, Fatmir Prifti, Kristo Huta, Ali Xhixha, Stephen R Connor
Sixty-percent of cancer patients are diagnosed with advanced stages of disease and those diagnosed in early stages face challenges to receive adequate treatment. Palliative care has had significant developments in recent years in Albania, due to a close partnership with the Ministry of Health, local non-profit organizations, and the Open Society Foundation Albania. In 2011, a five-year action plan for palliative care as one of four parts of the National Cancer Control Plan was approved. At the end of 2014, the first palliative care law was approved by Parliament...
August 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28807603/stem-cell-industry-update-2012-to-2016-reveals-accelerated-investment-but-market-capitalization-and-earnings-lag
#10
Mitchell Ng, Simon Song, Nicolas S Piuzzi, Kenneth Ng, Chukwuweike Gwam, Michael A Mont, George F Muschler
Treatments based on stem cells have long been heralded for their potential to drive the future of regenerative medicine and have inspired increasing medical and business interest. The stem cell therapy market has been expanding since 2012, but earnings and profitability still lag the broader health care sector (compounded annual growth rate in annual financing of 31.5% versus 13.4%, respectively). On the basis of historical financial data, approximately $23 billion has been invested in stem cell companies since 1994, with more than 80% of this raised from 2011 through 2016...
August 11, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28805913/feeding-distillers-grains-soybean-hulls-or-a-mixture-of-both-to-cows-as-a-forage-replacement-effects-on-intake-digestibility-and-ruminal-fermentation-characteristics
#11
W B Smith, K P Coffey, R T Rhein, E B Kegley, D Philipp, J G Powell, J D Caldwell, A N Young
Coproduct feedstuffs offer a unique and potentially profitable avenue for cattle feeding strategies. However, research is lacking in the evaluation of varying coproducts on ruminal fermentation and digestive characteristics when included as the major component of the diet of cows. Our objective was to determine the effect of coproduct feedstuffs as a forage replacement on digestive and fermentative characteristics of cows. Eight ruminally fistulated cows (672 ± 32.0 kg initial BW and approximately 9 yr of age) were stratified by BW and randomly allocated to 1 of 4 diets (2 cows∙diet∙period) in a 2-period study: soybean hulls (SH), distillers' dried grains with solubles (DG), an isoenergetic mixture of soybean hulls and distillers' dried grains with solubles (MX), or ad libitum hay plus 0...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805470/quality-and-readability-of-english-language-internet-information-for-aphasia
#12
Jamie H Azios, Monica Bellon-Harn, Ashley L Dockens, Vinaya Manchaiah
PURPOSE: Little is known about the quality and readability of treatment information in specific neurogenic disorders, such as aphasia. The purpose of this study was to assess quality and readability of English-language Internet information available for aphasia treatment. METHOD: Forty-three aphasia treatment websites were aggregated using five different country-specific search engines. Websites were then analysed using quality and readability assessments. Statistical calculations were employed to examine website ratings, differences between website origin and quality and readability scores, and correlations between readability instruments...
August 14, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28802338/context-in-quality-of-care-improving-teamwork-and-resilience
#13
REVIEW
Daniel S Tawfik, John Bryan Sexton, Kathryn C Adair, Heather C Kaplan, Jochen Profit
Quality improvement in health care is an ongoing challenge. Consideration of the context of the health care system is of paramount importance. Staff resilience and teamwork climate are key aspects of context that drive quality. Teamwork climate is dynamic, with well-established tools available to improve teamwork for specific tasks or global applications. Similarly, burnout and resilience can be modified with interventions such as cultivating gratitude, positivity, and awe. A growing body of literature has shown that teamwork and burnout relate to quality of care, with improved teamwork and decreased burnout expected to produce improved patient quality and safety...
September 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28799292/profits-and-prophets-derrida-on-linguistic-bereavement-and-im-possibility-in-nursing
#14
Barbara Pesut
The work of Jacques Derrida has received relatively little attention within nursing philosophy. Perhaps this is because Derrida is known best for deconstructing philosophy itself, a task he performed by making language unintelligible to make a point. This in itself makes his work daunting for nurses who do applied philosophy. Despite these difficulties, Derrida's focus on holding open a space for ideas, particularly those ideas that are invisible or unpopular, holds potential for enhancing the diversity of ideas within nursing...
August 11, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/28798848/a-mechanical-cell-disruption-microfluidic-platform-based-on-an-on-chip-micropump
#15
Yinuo Cheng, Yue Wang, Zhiyuan Wang, Liang Huang, Mingzhao Bi, Wenxiao Xu, Wenhui Wang, Xiongying Ye
Cell disruption plays a vital role in detection of intracellular components which contain information about genetic and disease characteristics. In this paper, we demonstrate a novel microfluidic platform based on an on-chip micropump for mechanical cell disruption and sample transport. A 50 μl cell sample can be effectively lysed through on-chip multi-disruption in 36 s without introducing any chemical agent and suffering from clogging by cellular debris. After 30 cycles of circulating disruption, 80...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28796916/fragrance-contact-allergens-in-5-588-cosmetic-products-identified-through-a-novel-smartphone-application
#16
Niels Højsager Bennike, Nikoline Bang Oturai, Stine Müller, Christel Søgaard Kirkeby, Claus Jørgensen, Anne Beck Christensen, Claus Zachariae, Jeanne Duus Johansen
BACKGROUND: More than 25% of the adult European population suffers from contact allergy, with fragrance substances recognized as one of the main causes. Since 2005, 26 fragrance contact allergens have been mandatory to label in cosmetic products within the EU if present at 10 ppm or above in leave-on and 100 ppm or above in wash-off cosmetics. OBJECTIVE: To examine exposure, based on ingredient labelling, to the 26 fragrances in a sample of 5,588 fragranced cosmetic products...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28795858/the-history-of-enhanced-recovery-after-surgery-and-the-eras-society
#17
Olle Ljungqvist, Tonia Young-Fadok, Nicolas Demartines
This short historical overview explains the development of enhanced recovery from a small group of surgeons in European academic centers to the establishment of ERAS(®)Society, a not-for-profit multiprofessional multidisciplinary medical-academic society, reaching all major continents and involving a wide range of surgical and anesthesia disciplines.
August 10, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28794204/chromosome-topology-guides-the-drosophila-dosage-compensation-complex-for-target-gene-activation
#18
Tamás Schauer, Yad Ghavi-Helm, Tom Sexton, Christian Albig, Catherine Regnard, Giacomo Cavalli, Eileen Em Furlong, Peter B Becker
X chromosome dosage compensation in Drosophila requires chromosome-wide coordination of gene activation. The male-specific lethal dosage compensation complex (DCC) identifies and binds to X-chromosomal high-affinity sites (HAS) from which it boosts transcription. A sub-class of HAS, PionX sites, represent first contacts on the X. Here, we explored the chromosomal interactions of representative PionX sites by high-resolution 4C and determined the global chromosome conformation by Hi-C in sex-sorted embryos. Male and female X chromosomes display similar nuclear architecture, concordant with clustered, constitutively active genes...
August 9, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28790959/brain-processing-of-contagious-itch-in-patients-with-atopic-dermatitis
#19
Christina Schut, Hideki Mochizuki, Shoshana K Grossman, Andrew C Lin, Christopher J Conklin, Feroze B Mohamed, Uwe Gieler, Joerg Kupfer, Gil Yosipovitch
Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that AD-patients could profit from when they are confronted with itch-inducing situations in daily life...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28783570/speech-reception-with-different-bilateral-directional-processing-schemes-influence-of-binaural-hearing-audiometric-asymmetry-and-acoustic-scenario
#20
Tobias Neher, Kirsten C Wagener, Matthias Latzel
Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric (N = 20) or asymmetric (N = 19) hearing thresholds for frequencies below 2 kHz, a large spread in the binaural intelligibility level difference (BILD), and no difference in age, overall degree of hearing loss, or performance on a measure of selective attention took part...
July 29, 2017: Hearing Research
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