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https://www.readbyqxmd.com/read/28944484/the-stem-cell-club-a-model-for-unrelated-stem-cell-donor-recruitment
#1
Warren Fingrut, Simran Parmar, Ari Cuperfain, Kiran Rikhraj, Erin Charman, Emilie Ptak, Manjot Kahlon, Alice Graham, Susan Luong, Yongjun George Wang, Janice Yu, Neha Arora, Roopa Suppiah, Edward W Li, Anna Lee, Christopher Welsh, Menachem Benzaquen, Alicia Thatcher, Iman Baharmand, Aedan Ladd, Tanya Petraszko, David Allan, Hans Messner
BACKGROUND: Patients with blood, immune, or metabolic diseases may require a stem cell transplant as part of their treatment. However, 70% of patients do not have a suitable human leukocyte antigen match in their family, and need an unrelated donor. Individuals can register as potential donors at stem cell drives, where they provide consent and a tissue sample for human leukocyte antigen typing. The ideal donors are young, male, and from a diversity of ethnic backgrounds. However, in Canada, non-Caucasian males ages 17 to 35 years represent only 8...
September 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28943160/home-health-agency-characteristics-and-quality-outcomes-for-medicare-beneficiaries-with-rehabilitation-sensitive-conditions
#2
Tracy M Mroz, Ann Meadow, Elizabeth Colantuoni, Bruce Leff, Jennifer L Wolff
OBJECTIVE: To examine associations between organizational characteristics of home health agencies (e.g., profit status, rehabilitation therapy staffing model, size, and rurality) and quality outcomes among Medicare beneficiaries with rehabilitation-sensitive conditions, conditions for which occupational, physical, and/or speech therapy have the potential to improve functioning, prevent or slow substantial decline in functioning, or increase ability to remain at home safely. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of Medicare administrative data for 1,006,562 fee-for-service beneficiaries admitted to 9,250 Medicare-certified home health agencies in 2009...
September 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28943061/nutritional-strategies-in-ruminants-a-lifetime-approach
#3
REVIEW
Joseph McGrath, Stéphane M Duval, Luis F M Tamassia, Maik Kindermann, René T Stemmler, Vinícius N de Gouvea, Tiago S Acedo, Irmgard Immig, Scot N Williams, Pietro Celi
This review examines the role of nutritional strategies to improve lifetime performance in ruminants. Strategies to increase ruminants' productive longevity by means of nutritional interventions provide the opportunity not only to increase their lifetime performances and their welfare, but also to decrease their environmental impact. This paper will also address how such nutritional interventions can increase herd efficiency and farm profitability. The key competencies reviewed in this article are redox balance, skeletal development and health, nutrient utilization and sustainability, which includes rearing ruminants without antibiotics and methane mitigation...
September 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28941641/targeting-tumor-associated-macrophages-the-new-challenge-for-nanomedicine
#4
REVIEW
Fernando Torres Andón, Elisabeth Digifico, Akihiro Maeda, Marco Erreni, Alberto Mantovani, María José Alonso, Paola Allavena
The engineering of new nanomedicines with ability to target and kill or re-educate Tumor Associated Macrophages (TAMs) stands up as a promising strategy to induce the effective switching of the tumor-promoting immune suppressive microenvironment, characteristic of tumors rich in macrophages, to one that kills tumor cells, is anti-angiogenic and promotes adaptive immune responses. Alternatively, the loading of monocytes/macrophages in blood circulation with nanomedicines, may be used to profit from the high infiltration ability of myeloid cells and to allow the drug release in the bulk of the tumor...
September 20, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28940917/determinants-of-transient-and-persistent-hospital-efficiency-the-case-of-italy
#5
Roberto Colombi, Gianmaria Martini, Giorgio Vittadini
In this paper, we extend the 4-random-component closed skew-normal stochastic frontier model by including exogenous determinants of hospital persistent (long-run) and transient (short-run) inefficiency, separated from unobserved heterogeneity. We apply this new model to a dataset composed by 133 Italian hospitals during the period 2008-2013. We show that average total inefficiency is about 23%, higher than previous estimates; hence, a model where the different types of inefficiency and hospital unobserved characteristics are not confounded allows us to get less biased estimates of hospital inefficiency...
September 2017: Health Economics
https://www.readbyqxmd.com/read/28939675/for-profit-hospital-status-and-carotid-artery-stent-utilization-in-us-hospitals-performing-carotid-revascularization
#6
Justin V Chandler, Benjamin P George, Adam G Kelly, Robert G Holloway
BACKGROUND AND PURPOSE: Carotid artery stenting may be an economically attractive procedure for hospitals and physicians. We sought to identify the association of hospital ownership (nonprofit versus for-profit) on carotid artery stenting (CAS) versus carotid endarterectomy utilization in US hospitals. METHODS: Using the Nationwide Inpatient Sample admissions for cerebrovascular disease from 2008 to 2011, we identified all private, nonfederal US hospitals performing at least 20 carotid revascularization procedures annually, including carotid artery stenting (International Classification of Diseases-Ninth Revision 00...
September 22, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28937963/ki67-and-lymphocytes-in-the-pretherapeutic-core-biopsy-of-primary-invasive-breast-cancer-positive-markers-of-therapy-response-prediction-and-superior-survival
#7
REVIEW
Claus M Schlotter, Lothar Tietze, Ulf Vogt, Carlos Villena Heinsen, Antje Hahn
Background Core needle biopsy plays a crucial role as diagnostic tool for BC. Both Ki67 and likely tumor-infiltrating lymphocytes (TILs) in the near future are determining the kind of systemic therapy. The role of TILs in BC is still an issue for clinical research, albeit preliminary results of neoadjuvant and adjuvant clinical studies already now highlight the crucial impact of TILs on therapy response and survival. Methods Evaluation of related publications (pubmed) and meeting abstracts (ASCO, SABCS). Results The monoclonal antibody Ki67 recognizing a nuclear antigene in proliferating cells is a positive marker of therapy response and superior survival...
September 22, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28936418/use-of-a-design-challenge-to-develop-postural-support-devices-for-intermediate-wheelchair-users
#8
Brenda N Onguti, Deepti Tanuku, Elizabeth J Himelfarb Hurwitz, Nathaniel C Moller, Youseph Yazdi, Shannon Egan, Eva S Bazant, Anthony Gichangi
The provision of an appropriate wheelchair, one that provides proper fit and postural support, promotes wheelchair users' physical health and quality of life. Many wheelchair users have postural difficulties, requiring supplemental postural support devices for added trunk support. However, in many low- and middle-income settings, postural support devices are inaccessible, inappropriate or unaffordable. This article describes the use of the design challenge model, informed by a design thinking approach, to catalyse the development of an affordable, simple and robust postural support device for low- and middle-income countries...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28935805/teaching-personal-initiative-beats-traditional-training-in-boosting-small-business-in-west-africa
#9
Francisco Campos, Michael Frese, Markus Goldstein, Leonardo Iacovone, Hillary C Johnson, David McKenzie, Mona Mensmann
Standard business training programs aim to boost the incomes of the millions of self-employed business owners in developing countries by teaching basic financial and marketing practices, yet the impacts of such programs are mixed. We tested whether a psychology-based personal initiative training approach, which teaches a proactive mindset and focuses on entrepreneurial behaviors, could have more success. A randomized controlled trial in Togo assigned microenterprise owners to a control group (n = 500), a leading business training program (n = 500), or a personal initiative training program (n = 500)...
September 22, 2017: Science
https://www.readbyqxmd.com/read/28933506/the-international-classification-of-functioning-disability-and-health-icf-in-electronic-health-records-a-systematic-literature-review
#10
Roxanne Maritz, Dominik Aronsky, Birgit Prodinger
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) is the World Health Organization's standard for describing health and health-related states. Examples of how the ICF has been used in Electronic Health Records (EHRs) have not been systematically summarized and described yet. OBJECTIVES: To provide a systematic review of peer-reviewed literature about the ICF's use in EHRs, including related challenges and benefits. METHODS: Peer-reviewed literature, published between January 2001 and July 2015 was retrieved from Medline(®), CINAHL(®), Scopus(®), and ProQuest(®) Social Sciences using search terms related to ICF and EHR concepts...
September 20, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28932204/how-followers-differing-in-career-motivation-gain-career-profits-from-transformational-leaders-a-longitudinal-moderated-mediation-model
#11
Anja Baethge, Thomas Rigotti, Sylvie Vincent-Hoeper
Although, transformational leadership is among the most thoroughly examined leadership theories, knowledge regarding its association with followers' career outcomes is still limited. Furthermore, the underlying mechanisms explaining how transformational leaders affect their employees' career success are yet not well-understood. Based on theoretical assumptions about the processes involved in setting the goal of "making a career," we propose an indirect effect of transformational leadership on subjective and objective career success via development opportunities that depends on the level of career motivation of employees...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28931795/examination-of-factors-that-influence-the-operation-income-and-expenditure-balance-difference-rate-of-20-educational-foundation-universities
#12
Hisato Nakajima, Kouya Yano, Kaoko Nagasawa, Satoka Katou, Kuninobu Yokota
OBJECTIVES: The objective of this study is to examine the factors that influence the operation income and expenditure balance ratio of school corporations running university hospitals by multiple regression analysis. METHODS: 1. We conducted cluster analysis of the financial ratio and classified the school corporations into those running colleges and universities.2. We conducted multiple regression analysis using the operation income and expenditure balance ratio of the colleges as the variables and the Diagnosis Procedure Combination data as the explaining variables...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28930277/biological-activities-of-three-essential-oils-of-the-lamiaceae-family
#13
REVIEW
Gema Nieto
Herbs and spices have been used since ancient times to improve the sensory characteristics of food, to act as preservatives and for their nutritional and healthy properties. Herbs and spices are generally recognized as safe (GRAS) and are excellent substitutes for chemical additives. Essential oils are mixtures of volatile compounds obtained, mainly by steam distillation, from medicinal and aromatic plants. They are an alternative to synthetic additives for the food industry, and they have gained attention as potential sources for natural food preservatives due to the growing interest in the development of safe, effective, natural food preservation...
August 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930198/joint-decisions-on-production-and-pricing-with-strategic-consumers-for-green-crowdfunding-products
#14
Yuting Chen, Rong Zhang, Bin Liu
Green crowdfunding is developing as a novel and popular transaction method, which can largely improve the efficiency of raising initial funds and selling innovative green products or services. In this paper, we explore the creator's joint decisions regarding green crowdfunding products of different quality levels that can sufficiently satisfy consumer preferences. Firstly, considering the characteristics of a green crowdfunding product, we present four pricing strategies when substitutes exist. Then we propose the optimal pricing strategies to maximize the total profit for the creator under different circumstances, facing strategic and myopic consumers...
September 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28929942/comparing-hospital-mission-statement-content-in-a-changing-healthcare-field
#15
Cory E Cronin, Douglas S Bolon
Mission statements are key elements of how an organization communicates its purpose and priorities to its community. This study considers how mission statements from Ohio, Florida, and Texas hospitals approach key concepts in healthcare - access, cost, and quality. It also considers the concept of community benefit, given its recent prevalence in policy changes. The analysis found quality represented within hospital mission statements at a rate of 65%, compared to 21% for access, 21% for cost, and 24% for community benefit...
September 20, 2017: Hospital Topics
https://www.readbyqxmd.com/read/28929315/somali-older-adults-and-their-families-perceptions-of-adult-home-health-services
#16
Sarah Miner, Dianne V Liebel, Mary H Wilde, Jennifer K Carroll, Sadiya Omar
Many studies have identified the vulnerability of ethnic elders, and there is promising evidence indicating home health care (HHC) services can improve the health outcomes of Somali older adults. This study used a community-engaged qualitative descriptive approach with the participation of non-profit organization Refugees Helping Refugees. The purpose of this study was to explore and describe Somali older adults' and their families' perceptions of and experiences with HHC services in order to improve its use and access...
September 20, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28929284/effects-of-beneficial-microorganisms-on-lowland-rice-development
#17
Adriano Stephan Nascente, Marta Cristina Corsi de Filippi, Anna Cristina Lanna, Thatyane Pereira de Sousa, Alan Carlos Alves de Souza, Valácia Lemes da Silva Lobo, Gisele Barata da Silva
Microorganisms can promote plant growth by increasing phytomass production, nutrient uptake, photosynthesis rates, and grain yield, which can result in higher profits for farmers. However, there is limited information available about the physiological characteristics of lowland rice after treatment with beneficial microorganisms in the tropical region. This study aimed to determine the effects of different beneficial microorganisms and various application forms on phytomass production, gas exchange, and nutrient contents in the lowland rice cultivar 'BRS Catiana' in a tropical region...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929207/-securpharm-e-%C3%A2-v-a%C3%A2-protective-shield-against-falsified-medicines
#18
REVIEW
Martin Bergen, Reinhard Hoferichter
It is the declared objective of the Falsified Medicines Directive 2011/62/EU to further improve the protection of patients from falsified pharmaceuticals. Therefore, it stipulates measures based on which falsified medicines in the supply chain can be more easily identified. This is the European legislature's reaction to an increase in falsified medicines. The EU Falsified Medicines Directive aims to create a uniform, standardized solution for protection from falsified drugs. From 9 February 2019 onward (according to the EU Regulation No...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28929171/-impact-of-european-e-commerce-liberalisation-on-pharmaceutical-crime-the-alpha-research-project
#19
REVIEW
Arndt Sinn
The trading of illicit and falsified pharmaceuticals is a growth market. Factors influencing this illegal market are high profit margins, a low risk of detection, low control density, an obscure legal situation, and lastly, the easy and anonymous ways of selling over the Internet, usually across national borders. This situation was the background for the research project on the impact of European e‑commerce liberalisation on pharmaceutical crime (ALPhA). The goal of the project was to develop concrete recommendations for action regarding the improved prosecution of internet-based pharmaceutical crime and to create a broad body of data for effective law-making by legislators...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28928730/fpr2-a-novel-promising-target-for-the-treatment-of-influenza
#20
REVIEW
Marie-Christine Alessi, Nicolas Cenac, Mustapha Si-Tahar, Béatrice Riteau
The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit. Annexin A1, one of the multiple ligands of FPR2, is incorporated in the budding virus membrane of influenza A viruses (IAV). Thereby, once IAV infect a host cell, FPR2 is activated. FPR2-signaling leads to an increase in viral replication, a dysregulation of the host immune response and a severe disease...
2017: Frontiers in Microbiology
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