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https://www.readbyqxmd.com/read/28817838/pharmacogenetic-determinants-of-outcomes-on-triplet-hepatic-artery-infusion-and-intravenous-cetuximab-for-liver-metastases-from-colorectal-cancer-european-trial-optiliv-nct00852228
#1
Francis Lévi, Abdoulaye Karaboué, Raphaël Saffroy, Christophe Desterke, Valerie Boige, Denis Smith, Mohamed Hebbar, Pasquale Innominato, Julien Taieb, Carlos Carvalho, Rosine Guimbaud, Christian Focan, Mohamed Bouchahda, René Adam, Michel Ducreux, Gérard Milano, Antoinette Lemoine
BACKGROUND: The hepatic artery infusion (HAI) of irinotecan, oxaliplatin and 5-fluorouracil with intravenous cetuximab achieved outstanding efficacy in previously treated patients with initially unresectable liver metastases from colorectal cancer. This planned study aimed at the identification of pharmacogenetic predictors of outcomes. METHODS: Circulating mononuclear cells were analysed for 207 single-nucleotide polymorphisms (SNPs) from 34 pharmacology genes...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28792014/applicability-of-the-direct-parameters-of-bioelectrical-impedance-in-assessing-nutritional-status-and-surgical-complications-of-women-with-gynecological-cancer
#2
I C R Cardoso, M A Aredes, G V Chaves
BACKGROUND/OBJECTIVES: Bioelectrical impedance vector analysis (BIVA) has been considered a promising technique in monitoring the nutritional and hydration status of patients with different types of diseases. The aim of this study was to assess the nutritional status provided by direct parameters of bioelectrical impedance analysis (BIA), BIVA and phase angle (PA), in patients with cervical and endometrial cancer undergoing surgical treatment, associating to other parameters of nutritional status and surgical outcomes...
August 9, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28792013/a-summary-of-meat-intakes-and-health-burdens
#3
REVIEW
C S C Yip, W Lam, R Fielding
This review summarizes published meta-analysis outcomes on the associations between meat intakes and burden of diseases. A novel assessment process was developed, combining selected Cochrane Review measures, AMSTAR checklist, and other quality measures identified by authors during preliminary phases of the review process. Meat intakes have been found to be statistically significant associated with 21 burden of diseases. A total of 37 risk-outcome best dose-response estimations were identified, all were positively associated, and 21 of them with low to moderate, or insignificant heterogeneity...
August 9, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28760787/bridging-the-age-gap-in-breast-cancer-evaluation-of-decision-support-interventions-for-older-women-with-operable-breast-cancer-protocol-for-a-cluster-randomised-controlled-trial
#4
Karen Collins, Malcolm Reed, Kate Lifford, Maria Burton, Adrian Edwards, Alistair Ring, Katherine Brain, Helena Harder, Thompson Robinson, Kwok Leung Cheung, Jenna Morgan, Riccardo Audisio, Susan Ward, Paul Richards, Charlene Martin, Tim Chater, Kirsty Pemberton, Anthony Nettleship, Christopher Murray, Stephen Walters, Oscar Bortolami, Fiona Armitage, Robert Leonard, Jacqui Gath, Deirdre Revell, Tracy Green, Lynda Wyld
INTRODUCTION: While breast cancer outcomes are improving steadily in younger women due to advances in screening and improved therapies, there has been little change in outcomes among the older age group. It is inevitable that comorbidities/frailty rates are higher, which may increase the risks of some breast cancer treatments such as surgery and chemotherapy, many older women are healthy and may benefit from their use. Adjusting treatment regimens appropriately for age/comorbidity/frailty is variable and largely non-evidence based, specifically with regard to rates of surgery for operable oestrogen receptor-positive disease and rates of chemotherapy for high-risk disease...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28751759/a-comparative-study-of-germline-brca1-and-brca2-mutation-screening-methods-in-use-in-20-european-clinical-diagnostic-laboratories
#5
Gillian Ellison, Andrew Wallace, Alexander Kohlmann, Simon Patton
BACKGROUND: Thousands of clinically relevant variations in BRCA1 and BRCA2 have been discovered and this poses a significant challenge with respect to the accurate detection, analysis turn-around time, characterisation and interpretation of these sequence variants. METHODS: We evaluated the performance of different BRCA1/2 gene testing practices in routine diagnostic use in 20 European laboratories, with a focus on next-generation sequencing-based strategies as this is the technical approach implemented by or under adoption by most European clinical laboratories...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28664917/harmonisation-of-biobanking-standards-in-endometrial-cancer-research
#6
M Adishesh, A Fyson, S B DeCruze, J Kirwan, H M J Werner, D K Hapangama
BACKGROUND: Endometrial cancer is the most common gynaecological cancer and its incidence is predicted to escalate by 50-100% in 2025 with a parallel increase in associated mortality. Variations in the collection, processing and storage of biospecimens can affect the generalisability of the scientific data. We aimed to harmonise the collection of biospecimens, clinical data relevant to endometrial cancer and to develop standard operative procedures for the collection, processing and storage of endometrial cancer biospecimens...
August 8, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28635950/genetically-predicted-high-body-mass-index-is-associated-with-increased-gastric-cancer-risk
#7
Yingying Mao, Caiwang Yan, Qun Lu, Meng Zhu, Fei Yu, Cheng Wang, Juncheng Dai, Hongxia Ma, Zhibin Hu, Hongbing Shen, Guangfu Jin
Epidemiological studies have linked body mass index (BMI) with risk of gastrointestinal cancers. However, for gastric cancer, the relationship is more controversial. In particular, it is unclear whether the observed association is due to confounding or bias inherent in conventional observational studies. To investigate whether BMI is causally associated with gastric cancer risk, we applied Mendelian randomization using individual-level data from 2631 gastric cancer cases and 4373 cancer-free controls. We derived a weighted genetic risk score (wGRS) using 37 BMI-associated genetic variants as an instrumental variable...
September 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28609434/pharmacologically-directed-strategies-in-academic-anticancer-drug-discovery-based-on-the-european-nci-compounds-initiative
#8
Hans R Hendriks, Anne-Sophie Govaerts, Iduna Fichtner, Sally Burtles, Andrew D Westwell, Godefridus J Peters
BACKGROUND: The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993. The objective was to help the NCI in reducing the backlog of in vivo testing of potential anticancer compounds, synthesised in Europe that emerged from the NCI in vitro 60-cell screen. METHODS: Over a period of more than twenty years the EORTC-Cancer Research Campaign panel reviewed ∼2000 compounds of which 95 were selected for further evaluation...
July 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28609433/prioritising-action-on-occupational-carcinogens-in-europe-a-socioeconomic-and-health-impact-assessment
#9
J W Cherrie, S Hutchings, M Gorman Ng, R Mistry, C Corden, J Lamb, A Sánchez Jiménez, A Shafrir, M Sobey, M van Tongeren, L Rushton
BACKGROUND: Work-related cancer is an important public health issue with a large financial impact on society. The key European legislative instrument is the Carcinogens and Mutagens Directive (2004/37/EC). In preparation for updating the Directive, the European Commission commissioned a study to provide a socioeconomic, health and environmental impact assessment. METHODS: The evaluation was undertaken for 25 preselected hazardous substances or mixtures. Estimates were made of the number of cases of cancer attributable to workplace exposure, both currently and in the future, with and without any regulatory interventions, and these data were used to estimate the financial health costs and benefits...
July 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28606464/corrigendum-to-phase-ib-dose-finding-study-of-abiraterone-acetate-plus-buparlisib-bkm120-or-dactolisib-bez235-in-patients-with-castration-resistant-prostate-cancer-european-journal-of-cancer-76-2017-36-44
#10
Christophe Massard, Kim Nguyen Chi, Daniel Castellano, Johann de Bono, Gwenaelle Gravis, Luc Dirix, Jean-Pascal Machiels, Alain Mita, Begoña Mellado, Sabine Turri, Joan Maier, Denes Csonka, Arunava Chakravartty, Karim Fizazi
No abstract text is available yet for this article.
August 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28592577/the-esmart-study-protocol-a-randomised-controlled-trial-to-evaluate-electronic-symptom-management-using-the-advanced-symptom-management-system-asyms-remote-technology-for-patients-with-cancer
#11
Roma Maguire, Patricia A Fox, Lisa McCann, Christine Miaskowski, Grigorios Kotronoulas, Morven Miller, Eileen Furlong, Emma Ream, Jo Armes, Elisabeth Patiraki, Alexander Gaiger, Geir V Berg, Adrian Flowerday, Peter Donnan, Paul McCrone, Kathi Apostolidis, Jenny Harris, Stylianos Katsaragakis, Alison R Buick, Nora Kearney
INTRODUCTION: While some evidence exists that real-time remote symptom monitoring devices can decrease morbidity and prevent unplanned admissions in oncology patients, overall, these studies have significant methodological weaknesses. The electronic Symptom Management using the Advanced Symptom Management System (ASyMS) Remote Technology (eSMART) study is designed to specifically address these weaknesses with an appropriately powered, repeated-measures, parallel-group stratified randomised controlled trial of oncology patients...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28585310/direct-acting-antivirals-for-chronic-hepatitis-c
#12
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs) are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). However, it is still questionable if eradication of hepatitis C virus in the blood eliminates hepatitis C in the body, and improves survival and leads to fewer complications...
June 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28513621/body-mass-index-and-mortality-in-lung-cancer-patients-a-systematic-review-and-meta-analysis
#13
REVIEW
J Wang, H Xu, S Zhou, D Wang, L Zhu, J Hou, J Tang, J Zhao, S Zhong
Studies examining the relation of body mass index (BMI) and mortality in patients with lung cancer have shown diverse results. We conducted a meta-analysis to investigate the association using all available studies from January 1982 to October 2016. PubMed and EMBASE were searched to identify relevant studies. We calculated the summary hazard ratio (HR) and 95% confidence interval (CI) using random effects model. The dose-response relationship was assessed by random effects meta-regression model. Fifty-five articles from 51 studies involving 3 152 552 subjects (males, 54...
May 17, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28503636/the-various-roles-of-oncology-nurse-specialists-an-international-perspective
#14
EDITORIAL
Ilana Kadmon
Ilana Kadmon, PhD, RN was for many years a nurse specialist in Breast Cancer at Hadassah Medical Center, Jerusalem, Israel. From 2016, she started the role of a nurse academic consultant at the nursing division at Hadassah. Her PhD is from The University of Edinburgh, UK. Her research involved psychosocial aspects of breast cancer, and the role of the breast care nurse (BCN). She was a pioneer in developing the post of the BCN in Israel. This position was initially developed by her at Hadassah and initiated by the Israel Cancer Association...
April 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28488692/mediterranean-diet-and-multiple-health-outcomes-an-umbrella-review-of-meta-analyses-of-observational-studies-and-randomised-trials
#15
REVIEW
M Dinu, G Pagliai, A Casini, F Sofi
Research has shown that a greater adherence to the Mediterranean diet is associated with a reduced risk of major chronic disease. However, the existing literature leads to debate for different issues, such as the measurement of the adherence to the Mediterranean diet, the use of a wide variety of dietary indices with various food components and the large heterogeneity across the studies. In order to summarise the evidence and evaluate the validity of the association between the adherence to the Mediterranean diet and multiple health outcomes, an umbrella review of the evidence across meta-analyses of observational studies and randomised clinical trials (RCTs) was performed...
May 10, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28488675/comparison-of-the-efficiency-of-colorectal-cancer-screening-programs-based-on-age-and-genetic-risk-for-reduction-of-colorectal-cancer-mortality
#16
Oliver Stanesby, Mark Jenkins
Given that colorectal cancer risk depends partly on inherited factors, screening program efficiency may be increased by incorporating genetic factors. We compared the efficiency of screening based on age and genetic risk in a simulated population. We simulated a population matching the size, age distribution and colorectal cancer incidence and mortality of Australia. We also simulated the distribution of genetic risk for colorectal cancer based on the expected number of inherited risk alleles of 45 single-nucleotide polymorphisms (SNPs) previously reported as associated with colorectal cancer...
June 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28441385/preoperative-clinical-pathway-of-breast-cancer-patients-determinants-of-compliance-with-eusoma-quality-indicators
#17
MULTICENTER STUDY
Delphine Héquet, Cyrille Huchon, Sandrine Baffert, Séverine Alran, Fabien Reyal, Thuy Nguyen, Alix Combes, Caroline Trichot, Karine Alves, Hélène Berseneff, Roman Rouzier
BACKGROUND: The European Society of Breast Cancer Specialists (EUSOMA) has defined quality indicators for breast cancer (BC). The aim of this study was to describe the preoperative clinical pathway of breast cancer patients and evaluate the determinants of compliance with EUSOMA quality indicators in the Optisoins01 cohort. METHODS: Optisoins01 is a prospective, multicentric study. Data from operable BC patients were collected, including results from before surgery to 1 year follow-up...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28378849/prediagnostic-enterolactone-concentrations-and-mortality-among-danish-men-diagnosed-with-prostate-cancer
#18
A K Eriksen, C Kyrø, N Nørskov, A K Bolvig, J Christensen, A Tjønneland, K Overvad, R Landberg, A Olsen
BACKGROUND/OBJECTIVES: Evidence on the role of diet in relation to prostate cancer progression is sparse. Foods rich in lignans have shown beneficial effects on prostate cancer progression in both animal studies and small human intervention studies, including beneficial effects on prostate-specific antigen levels and tumour growth. The lignan metabolite, enterolactone, has further shown to slow prostate cancer cell growth in vitro. The aim was to investigate the association between prediagnostic enterolactone concentrations and mortality among men with prostate cancer...
April 5, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28291621/a-comparison-of-research-into-cachexia-wasting-and-related-skeletal-muscle-syndromes-in-three-chronic-disease-areas
#19
Andrew J Stewart Coats, Louise G Shewan
INTRODUCTION: We compared the frequency of cancer, heart and lung related cachexia and cachexia-related research articles in the specialist journal, Journal of Cachexia, Sarcopenia and Muscle (JCSM) to those seen in a leading European journal in each specialist area during 2015 and 2016 to assess whether work on cachexia and related fields is relatively over or under represented in each specialist area. RESULTS: In the dedicated journal, Journal of Cachexia, Sarcopenia and Muscle, there were 44 references related to cancer, 5 related to respiratory disease, 5 related to heart failure, and 21 related to more than one of these chronic diseases...
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28272536/prediction-of-years-of-life-after-diagnosis-of-breast-cancer-using-omics-and-omic-by-treatment-interactions
#20
Agustín González-Reymúndez, Gustavo de Los Campos, Lucía Gutiérrez, Sophia Y Lunt, Ana I Vazquez
Breast cancer (BC) is the second most common type of cancer and a major cause of death for women. Commonly, BC patients are assigned to risk groups based on the combination of prognostic and prediction factors (eg, patient age, tumor size, tumor grade, hormone receptor status, etc). Although this approach is able to identify risk groups with different prognosis, patients are highly heterogeneous in their response to treatments. To improve the prediction of BC patients, we extended clinical models (including prognostic and prediction factors with whole-omic data) to integrate omics profiles for gene expression and copy number variants (CNVs)...
May 2017: European Journal of Human Genetics: EJHG
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