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https://www.readbyqxmd.com/read/28630182/study-of-biodistribution-and-in-vivo-anti-leishmanial-activity-of-a-distigmasterylhemisuccinoyl-glycero-phosphocholine-liposome-intercalated-amphotericin-b
#1
Maryam Iman, Zhaohua Huang, Seyedeh Hoda Alavizadeh, Francis C Szoka, Mahmoud R Jaafari
Distigmasterylhemisuccinoyl-sn-glycero-3- phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Our previous study revealed that a liposome-intercalated Amphotericin B prepared from DSHemsPC (DSHemsPC-Lip-AmB) possess excellent colloidal properties and in vitro antifungal and anti-leishmanial activity similar to AmBisome™. The aim of this study was to determine biodistribution and evaluate the anti-leishmanial effects of DSHemsPC-Lip-AmB in Leishmania major-infected BALB/c mice...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28625033/hydration-status-of-pregnant-women-in-west-jakarta
#2
Erry Yudhya Mulyani, Hardinsyah, Dodik Briawan, Budi Iman Santoso
BACKGROUND AND OBJECTIVES: During pregnancy, the body exhibits dynamic changes in fluid composition. More than 50%of women experience nausea and vomiting during the first trimester. Studies of hydration status in pregnant women are limited, and not in tropical countries, like in Indonesia. The objective of this study was to investigate the hydration status and appropriate biomarkers for determination of hydration status in pregnant women in West Jakarta. METHODS AND STUDY DESIGN: This study was cross-sectional...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28621738/integration-of-p-cuo-thin-sputtered-layers-onto-microsensor-platforms-for-gas-sensing
#3
Lionel Presmanes, Yohann Thimont, Imane El Younsi, Audrey Chapelle, Frédéric Blanc, Chabane Talhi, Corine Bonningue, Antoine Barnabé, Philippe Menini, Philippe Tailhades
P-type semiconducting copper oxide (CuO) thin films deposited by radio-frequency (RF) sputtering were integrated onto microsensors using classical photolithography technologies. The integration of the 50-nm-thick layer could be successfully carried out using the lift-off process. The microsensors were tested with variable thermal sequences under carbon monoxide (CO), ammonia (NH₃), acetaldehyde (C₂H₄O), and nitrogen dioxide (NO₂) which are among the main pollutant gases measured by metal-oxide (MOS) gas sensors for air quality control systems in automotive cabins...
June 16, 2017: Sensors
https://www.readbyqxmd.com/read/28619452/the-role-of-lecithin-degradation-on-the-ph-dependent-stability-of-halofantrine-encapsulated-fat-nano-emulsions
#4
Iman Haidar, Ian H Harding, Ian C Bowater, Daniel S Eldridge, William N Charman
We report on the successful incorporation of the antimalarial drug, halofantrine, into laboratory based soybean oil emulsions which were designed to mimic the commercially available parenteral fat emulsion, Intralipid(®). A high pH (minimum of pH 9, preferable pH of 11) was required for the drug laden emulsion to remain stable on storage and also to resist breaking under various stresses. Ageing of lecithin samples on storage was noted to result in degradation and a decrease in pH. We argue that this is the main reason for a similar decrease in pH for lecithin based emulsions and subsequent instability in drug laden emulsions...
June 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28618725/performing-icsi-with-commercial-microinjection-pipettes-enhanced-pregnancy-rates
#5
Mohammad Ali Khalili, Iman Halvaei, Shahin Ghazali, Mohammad Hossein Razi
BACKGROUND/AIM: Many technical factors can affect intracytoplasmic sperm injection (ICSI) outcomes. The role of the injection micropipette could be of vital importance in ICSI programs. The main goal was to compare ICSI pregnancy outcomes between commercial and home-made injection micropipettes in a large population with male factor infertility. MATERIALS AND METHODS: Five-hundred and eleven ICSI cycles with severe male factor were included in this retrospective study...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28615814/an-anatomical-study-for-localisation-of-zygomatic-branch-of-facial-nerve-and-masseteric-nerve-an-aid-to-nerve-coaptation-for-facial-reanimation-surgery-a-cadaver-based-study-in-eastern-india
#6
Ratnadeep Poddar, Alipta Bhattacharya, Iman Sinha, Asis Kumar Ghosal
CONTEXT: In cases of chronic facial palsy, where direct neurotisation is possible, ipsilateral masseteric nerve is a very suitable motor donor. We have tried to specifically locate the masseteric nerve for this purpose. AIMS: Describing an approach of localisation and exposure of both the zygomatic branch of Facial nerve and the nerve to masseter, with respect to a soft tissue reference point over face. SETTINGS AND DESIGN: Observational cross sectional study, conducted on 12 fresh cadavers...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28609658/a-systems-biology-approach-identifies-fut8-as-a-driver-of-melanoma-metastasis
#7
Praveen Agrawal, Barbara Fontanals-Cirera, Elena Sokolova, Samson Jacob, Christopher A Vaiana, Diana Argibay, Veronica Davalos, Meagan McDermott, Shruti Nayak, Farbod Darvishian, Mireia Castillo, Beatrix Ueberheide, Iman Osman, David Fenyö, Lara K Mahal, Eva Hernando
Association of aberrant glycosylation with melanoma progression is based mainly on analyses of cell lines. Here we present a systems-based study of glycomic changes and corresponding enzymes associated with melanoma metastasis in patient samples. Upregulation of core fucosylation (FUT8) and downregulation of α-1,2 fucosylation (FUT1, FUT2) were identified as features of metastatic melanoma. Using both in vitro and in vivo studies, we demonstrate FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28608562/t11ts-immunotherapy-repairs-pi3k-akt-signaling-in-t-cells-clues-towards-enhanced-t-cell-survival-in-rat-glioma-model
#8
Suhnrita Chaudhuri, Manoj Kumar Singh, Debanjan Bhattacharya, Ankur Datta, Iman Hazra, Somnath Mondal, Omar Faruk Sk Md, Larance Ronsard, Tushar Kanti Ghosh, Swapna Chaudhuri
Malignant glioma is the most fatal of astrocytic lineage tumors despite therapeutic advances. Onset and progression of gliomas is accompanied by severe debilitation of T-cell defense and T-cell survival. One of the chief contributors to T-cell survival downstream of activation is the PI3K-AKT pathway. Our prior studies showed that the novel immunotherapeutic molecule T11-target structure (T11TS) blocks T-cell apoptosis in glioma. We also showed activation of immunological synapse components and calcineurin-NFAT pathway following T11TS immunotherapy of glioma-bearing rats...
June 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28603834/abstracts-of-the-maghreb-medical-congress-2015
#9
A Dahmeni, M Bouchekoua, D Aloui, S Trabelsi, S Khaled, S Gara, B Herbegue, A Chetoui, S Sellami, I Slama, S Antit, E Boussabah, M Thameur, L Zakhama, S Benyoussef, F Guemira, N Bellil, D Gargouri, N Masmoudi, H Elloumi, N Bibani, D Trad, J Kharrat, I Tounsi, N Fakhfakh, A Kallel, N Hadj Salah, S Belhadj, S Ladab, K Kallell, I Ayadi, S Frikha, M Messaoud, S Belhaj, H Triki, K Kallel, S BenHamida, I Ghribi, A Belkhamsa, M Ben Hamida, I Cheikh, B Hamdi, S Maazaoui, A Berraies, H Sakly, H Blibech, J Ammar, A Hamzaoui, S Belaazri, F Lamine, A Baidada, A Kharbach, A Mensi, A Ben Mohammed, S Khedher, L Mouelhi, F Houissa, T Najjar, R BenJemàa, A Oukaa-Kchaou, I Ben Mefteh, A Ayachi, I Morjène, H Trabelsi, M Mourali, H Maghrebi, M Barka, A Haddad, A Jlassi, A Makni, A Daghfous, W Rebai, F Fteriche, F Chebbi, F Ksantini, A Ammous, M Jouini, M J Kacem, Z Ben Safta, M Cherif, H Zaafouri, A Bouhafa, A Ben Maamer, M Ben Khelifa, O Daboussi, K El Jeri, Y Said, M Salem, R Dabbech, M Hadidane, A Triki, H Henchiri, M Driss, J Ben Hassouna, M Hechiche, T Dhieb, K Rahal, J Lamghari, D Khaiz, Y Ghaddou, P Avala, K El Hattabi, F Z Bensardi, M R Lefriyekh, A Fadil, N O Zerouali, I Benahmed, M Karrou, K Benjaout, R Marouf, I Alloubi, L Achouri, M Slimene, B Laamouri, M Jendoubi, L Satouri, F Ghoul, H Reziga, M Malek, M K Makni, A Baba, A M Derbel, L Sellami, M Zili, R Khelifa, I Benahmed, K Benjaout, I Alloubi, R Maarouf, A Youssef, Bnr Amdouni, M Gharrad, M Saadaoui, M Mbarki, H Rezigua, C Shimi, J Semlani, S Amhajer, H Ghouda, Z Imane, M Gaouzi, Y Kriouile, M Attia, A Ben Amor, S Banneni, K Dimassi, A Triki, M F Gara, B Amdouni, L Bennasser, H Magherbi, I Jallouli, S Harabi, S Kbeili, M Derbel, H Gassara, D Louati, K Chaabene
No abstract text is available yet for this article.
August 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28601879/outcomes-in-melanoma-patients-treated-with-braf-mek-directed-therapy-or-immune-checkpoint-inhibition-stratified-by-clinical-trial-versus-standard-of-care
#10
Chloe Goldman, Jeremy Tchack, Eric M Robinson, Sung Won Han, Una Moran, David Polsky, Russell S Berman, Richard L Shapiro, Patrick A Ott, Iman Osman, Hua Zhong, Anna C Pavlick, Melissa Ann Wilson
OBJECTIVES: Since 2011, metastatic melanoma treatment has evolved with commercial approval of BRAF- and MEK-targeted therapy and CTLA-4- and PD-1-blocking antibodies (immune checkpoint inhibitors, ICI). While novel therapies have demonstrated improved prognosis in clinical trials, few studies have examined the evolution of prognosis and toxicity of these drugs among an unselected population. We assess whether survival and toxicity reported in trials, which typically exclude most patients with brain metastases and poor performance status, are recapitulated within a commercial access population...
June 10, 2017: Oncology
https://www.readbyqxmd.com/read/28601426/corrigendum-to-risk-stratification-and-pattern-of-cardiotoxicity-in-pediatric-ewing-sarcoma-j-egypt-natl-cancer-instit-29-2017-53-56
#11
Emad Moussa, Manal Zamzam, Ahmed Kamel, Zeinab Salah, Iman Attia, Lina Gaber, Ranin Soliman, Sameera Ezzat
No abstract text is available yet for this article.
June 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28596810/simulation-of-shear-bands-with-soft-particle-code-sparc-and-fe
#12
Barbara Schneider-Muntau, Chien-Hsun Chen, S M Iman Bathaeian
The aim of this paper is to numerically investigate the development, thickness and orientation of shear bands, in biaxial test with two approaches towards solving problems of continuum mechanics, namely the meshless "Soft PARticle" method and the mesh based Finite Element method. Soft PArticle Code (SPARC) is a straightforward collocation numerical method based on strong formulation, in which a first order polynomial basis is adopted for the evaluation of spatial derivatives in partial differential equations...
2017: GEM
https://www.readbyqxmd.com/read/28595652/effect-of-cochlear-implant-surgery-on-vestibular-function-meta-analysis-study
#13
REVIEW
Iman Ibrahim, Sabrina Daniela da Silva, Bernard Segal, Anthony Zeitouni
IMPORTANCE: Vestibular disorders have been reported following cochlear implant (CI) surgery, but the literature shows a wide discrepancy in the reported clinical impact. The aim of this meta-analysis is to quantify the effect of CI before and after surgery on the outcomes of vestibular tests, postural stability, and subjective perception of dizziness. OBJECTIVE: To evaluate the effects of CI surgery on vestibular function in adult patients (≥18 years) with sensorineural hearing loss who underwent unilateral or bilateral implantation...
June 8, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28594628/three-dimensional-versus-two-dimensional-laparoscopic-cholecystectomy-a-systematic-review
#14
Iman Komaei, Giuseppe Navarra, Giuseppe Currò
BACKGROUND AND AIMS: In the last decades, the three-dimensional (3D) imaging systems have been introduced in an attempt to improve depth perception and image quality during laparoscopic cholecystectomy interventions. The goal of our systematic review was to provide enough convincing evidences on superiority and benefits of 3D over two-dimensional (2D) imaging systems, from both surgeon's and patient's point of view, justifying the cost-effectiveness of newly developed 3D systems. METHODS: Two authors separately performed a full literature search aiming to find randomized controlled trials evaluating the advantages and disadvantages of 3D versus 2D laparoscopic cholecystectomy procedures...
June 8, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28593608/tumor-necrosis-factor-%C3%AE-308-a-g-gene-polymorphism-in-children-with-juvenile-idiopathic-arthritis-relation-to-disease-activity-damage-and-functional-status
#15
Iman I El Gazzar, Hanan M Fathy, Tamer A Gheita, Abeer M Nour El-Din, Enas Abdel Rasheed, Rasha H Bassyouni, Sanaa A Kenawy
The study aims to evaluate the clinical significance of serum levels of tumor necrosis factor alpha (TNF-α) and -308 A/G promoter polymorphism in juvenile idiopathic arthritis (JIA) patients and find any association to the subsets, clinical and laboratory features, disease activity, and damage as well as functional disability. Forty-eight JIA children and 30 controls were included in the present study. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated, juvenile arthritis damage index (JADI) was assessed, and Childhood Health Assessment Questionnaire (CHAQ) measured the functional status...
June 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28585040/water-demand-forecasting-review-of-soft-computing-methods
#16
Iman Ghalehkhondabi, Ehsan Ardjmand, William A Young, Gary R Weckman
Demand forecasting plays a vital role in resource management for governments and private companies. Considering the scarcity of water and its inherent constraints, demand management and forecasting in this domain are critically important. Several soft computing techniques have been developed over the last few decades for water demand forecasting. This study focuses on soft computing methods of water consumption forecasting published between 2005 and 2015. These methods include artificial neural networks (ANNs), fuzzy and neuro-fuzzy models, support vector machines, metaheuristics, and system dynamics...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28584310/effects-of-external-loading-on-lumbar-extension-moment-during-squat-lifting
#17
Iman Vahdat, Mostafa Rostami, Farhad Tabatabai Ghomsheh, Siamak Khorramymehr, Ali Tanbakoosaz
OBJECTIVES: The main objective of this study has been qualitative investigation of the effects of external loading on the lumbar extension moment during squat lifting. Findings of this study may allow to determine the factor with the most considerable effect on the lumbar extension moment and may help determine the lumbar spine risk factors at temporo-spatial coordination during squat lifting. MATERIAL AND METHODS: Twelve healthy men volunteered to perform slow and fast squat lifting of a box of varied mass (4 kg, 8 kg and 12 kg)...
May 29, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28580449/administration-of-high-dose-of-methamphetamine-has-detrimental-effects-on-sperm-parameters-and-dna-integrity-in-mice
#18
Mojdeh Sabour, Arezoo Khoradmehr, Seyyed Mehdi Kalantar, Amir Hossein Danafar, Marjan Omidi, Iman Halvaei, Ali Nabi, Saeed Ghasemi-Esmailabad, Ali Reza Talebi
BACKGROUND: Methamphetamine (MA) was shown to have harmful effects on male reproductive system. OBJECTIVE: To investigate probable effects of daily administration of MA on sperm parameters and chromatin/DNA integrity in mouse. MATERIAL AND METHODS: Thirty-five NMRI male mice were divided into five groups including low, medium, and high dosage groups which were injected intraperitoneally with 4, 8 and 15 mg/kg/day for 35 days, respectively...
March 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28578965/preparation-and-evaluation-of-polyurethane-cellulose-nanowhisker-bimodal-foam-nanocomposites-for-osteogenic-differentiation-of-hmscs
#19
Ehsan Shahrousvand, Mohsen Shahrousvand, Marzieh Ghollasi, Ehsan Seyedjafari, Iman Sahebi Jouibari, Amir Babaei, Ali Salimi
Biocompatible and biodegradable polyurethanes (PUs) based on polycaprolactone diol (PCL) were prepared and filled with cellulose nanowhiskers (CNWs) obtained from wastepaper. The incorporated polyurethane nanocomposites were used to prepare foamed scaffolds with bimodal cell sizes through solvent casting/particulate leaching method. Sodium chloride and sugar porogens were also prepared to fabricate the scaffolds. The mechanical and thermal properties of PU/CNW nanocomposites were investigated. Incorporation of different CNWs resulted in various structures with tunable mechanical properties and biodegradability...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28578640/inorganic-and-metal-nanoparticles-and-their-antimicrobial-activity-in-food-packaging-applications
#20
Mahmoud Hoseinnejad, Seid Mahdi Jafari, Iman Katouzian
Nanotechnology has revolutionized almost all the fields of science and technology, particularly the food packaging industry. Accordingly, some nanoparticles can be used in food contact materials to preserve food products for longer periods. To date, many inorganic and metal nanoparticles have been implemented to synthesize active food packaging materials and to extend the shelf-life of foods. Packaging with nanocomposites containing these nanoparticles offers advantages, such as reduction in the usage of preservatives and higher rate of reactions to inhibit the microbial growth...
June 3, 2017: Critical Reviews in Microbiology
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