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https://www.readbyqxmd.com/read/27916501/association-between-iron-level-glucose-impairment-and-increased-dna-damage-during-pregnancy
#1
Salam Zein, Samar Rachidi, Nadine Shami, Iman Sharara, Khawla Cheikh-Ali, Anne-Sophie Gauchez, Jean-Marc Moulis, Jean-Marc Ayoubi, Pascale Salameh, Isabelle Hininger-Favier
: Elevated circulating ferritin has been reported to increase the risk of gestational diabetes mellitus (GDM). When high ferritin translates into high iron stores, iron excess is also a condition leading to free radical damage. We aimed to evaluate the relationship between oxidative stress (OS) induced by iron status and GDM risk in non iron-supplemented pregnant women. METHODS: This was a pilot observational study conducted on 93 non-anemic pregnant women. Iron status was assessed at the first trimester of gestation...
November 18, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27901474/cerebellar-neurochemical-and-histopathological-changes-in-rat-model-of-parkinson-s-disease-induced-by-intrastriatal-injection-of-rotenone
#2
Yasser A Khadrawy, Iman M Mourad, Haitham S Mohammed, Neveen A Noor, Heba S Aboul Ezz
The aim of the present work was to investigate the neurochemical changes induced in the cerebellum of rat model of Parkinson's disease (PD). Rats were divided into two groups; control and rat model of PD induced by the intrastriatal injection of rotenone. As compared to control, a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine were observed in the cerebellum of rat model of PD...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27896234/frequency-and-associated-factors-of-amphotericin-b-nephrotoxicity-in-hospitalized-patients-in-hematology-oncology-wards-in-the-southwest-of-iran
#3
Iman Karimzadeh, Marziyeh Heydari, Mani Ramzi, Mohammad Mahdi Sagheb
BACKGROUND: Nephrotoxicity is the most clinically significant adverse reaction of amphotericin B. Different aspects of amphotericin B (AmB) nephrotoxicity have not been studied well in our population. OBJECTIVES: The purpose of this study was to assess the frequency, time onset, and possible associated factors of AmB nephrotoxicity in hospitalized patients in hematology-oncology wards in the southwest of Iran. PATIENTS AND METHODS: A cross-sectional, observational study was performed over a period of 9 months at 2 hematology-oncology and 1 hematopoietic stem cell transplantation wards at Namazi Hospital...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27890154/effects-of-tool-handle-dimension-and-workpiece-orientation-and-size-on-wrist-ulnar-radial-torque-strength-usability-and-discomfort-in-a-wrench-task
#4
Iman Dianat, Soleyman Rahimi, Moein Nedaei, Mohammad Asghari Jafarabadi, Ali E Oskouei
The effects of tool handle dimension (three modified designs of wrenches with 30-50 mm diameter cylindrical handles and traditional design with rectangular cross-sectional (5 mm × 25 mm) handle), workpiece orientation (vertical/horizontal) and workpiece size (small/large) as well as user's hand size on wrist ulnar/radial (U/R) torque strength, usability and discomfort, and also the relationship between these variables were evaluated in a maximum torque task using wrenches. The highest and lowest levels of maximal wrist U/R torque strength were recorded for the 30 mm diameter handle and traditional wrench design, respectively...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27886012/histogram-based-feature-extraction-from-individual-gray-matter-similarity-matrix-for-alzheimer-s-disease-classification
#5
Iman Beheshti, Norihide Maikusa, Hiroshi Matsuda, Hasan Demirel, Gholamreza Anbarjafari
Automatic computer-aided diagnosis (CAD) systems have been widely used in classification of patients who suffer from Alzheimer's disease (AD). This paper presents an automatic CAD system based on histogram feature extraction from single-subject gray matter similarity-matrix for classifying the AD patients from healthy controls (HC) using structural magnetic resonance imaging (MRI) data. The proposed CAD system is composed of five stages. In the first stage, segmentation is employed to perform pre-processing on the MRI images, and segment into gray matter, white matter, and cerebrospinal fluid using the voxel-based morphometric toolbox procedure...
November 19, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27884670/preparation-of-ecofriendly-uv-protective-food-packaging-material-by-starch-tio2-bio-nanocomposite-characterization
#6
Vahid Goudarzi, Iman Shahabi-Ghahfarrokhi, Amin Babaei-Ghazvini
In this study, ecofriendly starch/TiO2 bio-nanocomposites were produced using with different nano-TiO2 (TiO2) content (1, 3, and 5 (wt%)). Physical, mechanical, thermal, water-vapor permeability (WVP) properties and UV transmittance were investigated. Our results showed that the increasing TiO2 content increased the hydrophobicity of starch/TiO2 films. WVP of the bio-nanocomposites was reduced, simultaneously. With increasing TiO2 content, tensile strength and Young's modulus of the film specimens were reduced while elongation at break and tensile energy to break were increased...
November 21, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27884618/effect-of-materials-mixture-on-the-higher-heating-value-case-of-biomass-biochar-and-municipal-solid-waste
#7
Imane Boumanchar, Younes Chhiti, Fatima Ezzahrae M'hamdi Alaoui, Amal El Ouinani, Abdelaziz Sahibed-Dine, Fouad Bentiss, Charafeddine Jama, Mohammed Bensitel
The heating value describes the energy content of any fuel. In this study, this parameter was evaluated for different abundant materials in Morocco (two types of biochar, plastic, synthetic rubber, and cardboard as municipal solid waste (MSW), and various types of biomass). Before the evaluation of their higher heating value (HHV) by a calorimeter device, the thermal behavior of these materials was investigated using thermogravimetric (TGA) and Differential scanning calorimetry (DSC) analyses. The focus of this work is to evaluate the calorific value of each material alone in a first time, then to compare the experimental and theoretical HHV of their mixtures in a second time...
November 21, 2016: Waste Management
https://www.readbyqxmd.com/read/27882069/hepatitis-c-and-g-virus-infection-prevalence-among-hemodialysis-patients-and-associated-risk-factors-in-the-hormozgan-province-of-southern-iran
#8
Ali Kargar Kheirabad, Fahime Bahri, Mohammad Kargar, Iman Ghasemzadeh
BACKGROUND: Infection with blood-borne viruses including hepatitis C (HCV) and hepatitis G (HGV) viruses is a substantial health problem. Varying prevalences of these infections in different studies reflect the role of predisposing risk factors in different countries or even different regions of a country. OBJECTIVES: The objective of the present survey was to assess the prevalences of HCV and HGV virus infections among hemodialysis (HD) patients in Bandar Abbas, Hormozgan, Iran, 2015...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27876903/alternations-in-the-liver-enzymatic-activity-of-common-carp-cyprinus-carpio-in-response-to-parasites-dactylogyrus-spp-and-gyrodactylus-spp
#9
Abulhasan Rastiannasab, Shiva Afsharmanesh, Ruhollah Rahimi, Iman Sharifian
The present study was carried out to investigate the effects of parasites, monogenea, Dactylogyrus spp. and Gyrodactylus spp. on some enzymatic and biochemical components of liver in healthy and infected common carp, Cyprinus carpio. For this purpose, 10 healthy and 10 infected fish were collected from farm. The blood samples were taken and after separation of serum, the values of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) enzymes activities as well as Creatinine and Urea were measured...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27872168/accurate-carbohydrate-counting-is-an-important-determinant-of-postprandial-glycemia-in-children-and-adolescents-with-type-1-diabetes-on-insulin-pump-therapy
#10
Asma Deeb, Ahlam Al Hajeri, Iman Alhmoudi, Nico Nagelkerke
BACKGROUND: Carbohydrate (CHO) counting is a key nutritional intervention utilized in the management of diabetes to optimize postprandial glycemia. The aim of the study was to examine the impact of accuracy of CHO counting on the postprandial glucose in children and adolescents with type 1 diabetes on insulin pump therapy. METHODS: Children/adolescents with type 1 diabetes who were on insulin pump therapy for a minimum of 6 months are enrolled in the study. Patients were instructed to record details of meals consumed, estimated CHO count per meal, and 2-hour postprandial glucose readings over 3-5 days...
November 20, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27870112/erratum
#11
Samah F Ibrahim, Iman F Gaballah, Laila A Rashed
No abstract text is available yet for this article.
November 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27869240/relationship-between-occupational-stress-and-cardiovascular-diseases-risk-factors-in-drivers
#12
Hamed Biglari, Mohammad Hossein Ebrahimi, Maryam Salehi, Mohsen Poursadeghiyan, Iman Ahmadnezhad, Milad Abbasi
OBJECTIVES: Of all work stressors, occupational stress is the leading cause of many disorders among workers. Drivers are classified as a high risk group for work related stress. This study set out to determine the relationship between risk factors of cardiovascular diseases and occupational stress among drivers. MATERIAL AND METHODS: Two hundred and twenty two Ilam's intercity drivers were selected for the study. For measuring work stress, the Osipow work stress questionnaire was used...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27864044/localization-methods-for-excisional-biopsy-in-women-with-nonpalpable-mammographic-abnormalities
#13
Christine Rodhouse, Iman Soliman, Mariah Cruse, Joseph Kastrenakes, C J Augustine, Alexis Ludy, Eric Reintgen, Alexa Hoadley, Divya Desai, Minh Nguyen, Douglas Scott Reintgen
INTRODUCTION: With the advent and proliferation of breast cancer screening programs, more women are being diagnosed with mammographic abnormalities that require tissue diagnosis. If imaged-guided biopsy is not possible or previous image-guided biopsies reveal pathologies that require more extensive surgery, guided excisional biopsy/lumpectomy may be necessary. METHODS: Fifteen women were enrolled in the study of the feasibility of off-site or day-before wire-localization excisional biopsy of the breast with mammographic abnormalities...
October 19, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27863452/mutation-in-non-coding-rna-rnu12-causes-early-onset-cerebellar-ataxia
#14
Mahmoud Fawzi Elsaid, Nader Chalhoub, Tawfeg Ben-Omran, Pankaj Kumar, Hussein Kamel, Khalid Ibrahim, Yasmin Mohamoud, Eman Al-Dous, Iman Al-Azwani, Joel A Malek, Karsten Suhre, M Elizabeth Ross, Alice Abdel Aleem
OBJECTIVE: Exome sequences account for only 2% of the genome and may overlook mutations causing disease. To obtain a more complete view, whole genome sequencing (WGS) was analyzed in a large consanguineous family in which members displayed autosomal recessively inherited cerebellar ataxia manifesting before two years of age. METHODS: WGS from blood derived gDNA was used for homozygosity mapping and a rare variant search. RNA from isolated blood leukocytes was used for quantitative PCR, RNA sequencing and comparison of the transcriptomes of affected and unaffected family members...
November 18, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27858324/a-bifunctional-aminoglycoside-acetyltransferase-phosphotransferase-conferring-tobramycin-resistance-provides-an-efficient-selectable-marker-for-plastid-transformation
#15
Iman Tabatabaei, Stephanie Ruf, Ralph Bock
A new selectable marker gene for stable transformation of the plastid genome was developed that is similarly efficient as the aadA, and produces no background of spontaneous resistance mutants. More than 25 years after its development for Chlamydomonas and tobacco, the transformation of the chloroplast genome still represents a challenging technology that is available only in a handful of species. The vast majority of chloroplast transformation experiments conducted thus far have relied on a single selectable marker gene, the spectinomycin resistance gene aadA...
November 17, 2016: Plant Molecular Biology
https://www.readbyqxmd.com/read/27856238/evaluation-of-known-and-novel-inhibitors-of-orai1-mediated-store-operated-ca-2-entry-in-mda-mb-231-breast-cancer-cells-using-a-fluorescence-imaging-plate-reader-assay
#16
Iman Azimi, Jack U Flanagan, Ralph J Stevenson, Marco Inserra, Irina Vetter, Gregory R Monteith, William A Denny
The Orai1 Ca(2+) permeable ion channel is an important component of store operated Ca(2+) entry (SOCE) in cells. It's over-expression in basal molecular subtype breast cancers has been linked with poor prognosis, making it a potential target for drug development. We pharmacologically characterised a number of reported inhibitors of SOCE in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader (FLIPR) assay, and show that the rank order of their potencies in this assay is the same as those reported in a wide range of published assays...
November 7, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27855613/hoxb7-and-hsa-mir-222-as-the-potential-therapeutic-candidates-for-metastatic-colorectal-cancer
#17
Maryam Iman, Seyede Samaneh Mostafavi, Seyed Shahriar Arab, Sadegh Azimzadeh, Mansour Poorebrahim
BACKGROUND: Recent studies have shown that the high mortality of patients with colorectal cancer (CRC) is related to its ability to spread the surrounding tissues, thus there is a need for designing and developing new drugs. OBJECTIVE: Here, we proposed a combinational therapy strategy, an inhibitory peptide in combination with miRNA targeting, for modulating CRC metastasis. In this study, some of the recent patents were also reviewed. METHODS: After data analysis with GEO2R and gene annotation using DAVID server, regulatory interactions of differentially expressed genes (DEGs) were obtained from STRING, GeneMANIA, KEGG and TRED databases...
2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27853304/genetic-epidemiology-of-glucose-6-dehydrogenase-deficiency-in-the-arab-world
#18
C George Priya Doss, Dima R Alasmar, Reem I Bux, P Sneha, Fadheela Dad Bakhsh, Iman Al-Azwani, Rajaa El Bekay, Hatem Zayed
A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) in the 22 Arab countries. Our search yielded 43 studies that captured 33 mutations (23 missense, one silent, two deletions, and seven intronic mutations), in 3,430 Arab patients with G6PDD. The 23 missense mutations were then subjected to phenotypic classification using in silico prediction tools, which were compared to the WHO pathogenicity scale as a reference...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847544/effects-of-reynolds-and-womersley-numbers-on-the-hemodynamics-of-intracranial-aneurysms
#19
Hafez Asgharzadeh, Iman Borazjani
The effects of Reynolds and Womersley numbers on the hemodynamics of two simplified intracranial aneurysms (IAs), that is, sidewall and bifurcation IAs, and a patient-specific IA are investigated using computational fluid dynamics. For this purpose, we carried out three numerical experiments for each IA with various Reynolds (Re = 145.45 to 378.79) and Womersley (Wo = 7.4 to 9.96) numbers. Although the dominant flow feature, which is the vortex ring formation, is similar for all test cases here, the propagation of the vortex ring is controlled by both Re and Wo in both simplified IAs (bifurcation and sidewall) and the patient-specific IA...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27843959/antimicrobial-resistance-pattern-of-gram-positive-bacteria-during-three-consecutive-years-at-the-nephrology-ward-of-a-tertiary-referral-hospital-in-shiraz-southwest-iran
#20
Iman Karimzadeh, Mona Mirzaee, Niloofar Sadeghimanesh, Mohammad Mahdi Sagheb
OBJECTIVE: The aim of the present study was to determine the pattern of antimicrobial resistance of Gram-positive bacteria during three consecutive years at the nephrology ward of Namazi Hospital in Shiraz, Southwest of Iran. METHODS: During a 3-year period from 2013 to 2015, data of all biological samples of hospitalized patients at the adult nephrology ward of Namazi Hospital were sent to the central laboratory for identification of Gram-positive microorganisms and subsequently, their antimicrobial susceptibility testing by Kirby-Bauer disc diffusion method were analyzed in a retrospective manner...
October 2016: Journal of Research in Pharmacy Practice
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