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https://www.readbyqxmd.com/read/29792956/development-of-photo-modified-starch-kefiran-tio-2-bio-nanocomposite-as-an-environmentally-friendly-food-packaging-material
#1
Vahid Goudarzi, Iman Shahabi-Ghahfarrokhi
This paper reports on an experiment in which starch/kefiran/TiO2 (SKT)-based bio-nanocomposite films were developed and modified by photo-chemical reaction. In so doing, film-forming solutions were exposed to ultraviolet A (UV-A) for different times (1, 6, and 12 h). The obtained results indicated that increasing UV-A exposure time brought about an increase (≈14.9%) in the tensile strength of bio-nanocomposites. However, elongation at break and Young's modulus of irradiated film specimen decreased (≈32%, ≈12%, respectively) by increasing UV-A exposure time, and the moisture-sensitive parameters of specimen decreased using UV-A irradiation...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29789461/co-morbidities-as-predictors-of-airflow-limitation-among-smokers-in-england
#2
Reem Kayyali, Yusur Hassan, Iman Hesso, Roshan Siva
The prevalence of co-morbidities among patients with Chronic Obstructive Pulmonary Disease (COPD) is well documented in the literature. Therefore, this pilot study aimed to identify whether co-morbidities screening would enhance COPD case-finding. Smoking patients were approached at Croydon University Hospital and two local community pharmacies (CPs). Their co-morbidities, respiratory symptoms, smoking pack-years and exercise capacity were collected. Airflow limitation was determined using handheld spirometry (COPD-6) device...
May 22, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29780227/neurophysiologic-tests-screening-cognitive-impairment-in-idiopathic-intracranial-hypertension-patients
#3
Iman A Elbanhawy, Gihan M Ramzy, Mye A Basheer, Diana M Khedr
Background: Idiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure of obscure cause. Patients with IIH may suffer from difficulty in thinking or concentrating. This work aimed at highlighting the neurophysiologic suggestions of cognitive impairment in IIH patients. Methods: Twenty patients with IIH-and a similar number of matched control subjects-were examined in this case-control study. The P300 and contingent negative variation (CNV) were performed...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29776832/an-sar-study-of-hydroxy-trifluoromethylpyrazolines-as-inhibitors-of-orai1-mediated-store-operated-ca-2-entry-in-mda-mb-231-breast-cancer-cells-using-a-convenient-fluorescence-imaging-plate-reader-assay
#4
Ralph J Stevenson, Iman Azimi, Jack U Flanagan, Marco Inserra, Irina Vetter, Gregory R Monteith, William A Denny
The proteins Orai1 and STIM1 control store-operated Ca2+ entry (SOCE) into cells. SOCE is important for migration, invasion and metastasis of MDA-MB-231 human triple negative breast cancer (TNBC) cells and has been proposed as a target for cancer drug discovery. Two hit compounds from a medium throughput screen, displayed encouraging inhibition of SOCE in MDA-MB-231 cells, as measured by a Fluorescence Imaging Plate Reader (FLIPR) Ca2+ assay. Following NMR spectroscopic analysis of these hits and reassignment of their structures as 5-hydroxy-5-trifluoromethylpyrazolines, a series of analogues was prepared via thermal condensation reactions between substituted acylhydrazones and trifluoromethyl 1,3-dicarbonyl arenes...
May 9, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29775228/uroprotective-mechanism-of-quercetin-against-cyclophosphamide-induced-urotoxicity-effect-on-oxidative-stress-and-inflammatory-markers
#5
Iman O Sherif
The urotoxicity is a common complication associated with patients receiving cyclophosphamide (CYP). This study was designed to investigate the uroprotective mechanism of quercetin (Quer) flavonoid against CYP induced urotoxicity via determination of oxidative stress markers as well as inflammatory mediators in bladder tissue. Forty male Wistar rats were divided into four groups; Normal group: received saline for 10 days. Quer control group: received quercetin 50 mg/kg/day for 10 days. CYP group: received saline for 10 days and injected with a single dose of 150 mg/kg CYP intraperitoneal (i...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29773080/adjuvant-ny-eso-1-vaccine-immunotherapy-in-high-risk-resected-melanoma-a-retrospective-cohort-analysis
#6
Michael Lattanzi, Joseph Han, Una Moran, Kierstin Utter, Jeremy Tchack, Rachel Lubong Sabado, Russell Berman, Richard Shapiro, Hsin-Hui Huang, Iman Osman, Nina Bhardwaj, Anna C Pavlick
BACKGROUND: Cancer-testis antigen NY-ESO-1 is a highly immunogenic melanoma antigen which has been incorporated into adjuvant vaccine clinical trials. Three such early-phase trials were conducted at our center among patients with high-risk resected melanoma. We herein report on the pooled long-term survival outcomes of these patients in comparison to historical controls. METHODS: All melanoma patients treated at NYU Langone Health under any of three prospective adjuvant NY-ESO-1 vaccine trials were retrospectively pooled into a single cohort...
May 18, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29769012/synthesis-in-silico-and-in-vitro-cytostatic-activity-of-new-lipophilic-derivatives-of-hydroxyurea
#7
Zeynab Khansepid, Asghar Davood, Maryam Iman, Mahdi Fasihi Ramandi
BACKGROUND: Hydroxyurea (HU) is used to treat cancer., HU has a short half-life due to its small molecular weight and high polarity, therefore a high dosage of the drug should be used which introduces side effects and more rapid development of resistance. OBJECTIVE: The objective of the current study is to design a new lipophilic analogues of hydroxyurea with higher stability and better cell penetration. Then Tthe designed compoundsdrug wereas synthesized and then evaluated in terms of theirthe cytostatic activiactivitiesty was evaluated against two human cell linesthe Panc and Hella cell lines...
May 16, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29767391/self-expanding-metallic-biliary-stents-time-to-suit-up
#8
EDITORIAL
Iman Andalib, Michel Kahaleh
No abstract text is available yet for this article.
May 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29762559/gas-spectroscopy-with-integrated-frequency-monitoring-through-self-mixing-in-a-terahertz-quantum-cascade-laser
#9
Rabi Chhantyal-Pun, Alexander Valavanis, James T Keeley, Pierluigi Rubino, Iman Kundu, Yingjun Han, Paul Dean, Lianhe Li, A Giles Davies, Edmund H Linfield
We demonstrate a gas spectroscopy technique, using self-mixing in a 3.4 terahertz quantum-cascade laser (QCL). All previous QCL spectroscopy techniques have required additional terahertz instrumentation (detectors, mixers, or spectrometers) for system pre-calibration or spectral analysis. By contrast, our system self-calibrates the laser frequency (i.e., with no external instrumentation) to a precision of 630 MHz (0.02%) by analyzing QCL voltage perturbations in response to optical feedback within a 0-800 mm round-trip delay line...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29757792/baclofen-pump-replacement-in-a-patient-with-end-stage-amyotrophic-lateral-sclerosis-a-case-report-demonstrating-transversus-abdominis-plane-block-as-the-sole-anesthetic
#10
Iman A Hadaya, Andrew T Gray, Matthias R Braehler
A patient with end-stage amyotrophic lateral sclerosis (ALS) presented for Baclofen pump replacement. She underwent a left transversus abdominis plane block to anesthetize the left lower quadrant of the abdomen. No sedatives or analgesics were administered, and the procedure was successfully completed without complication. It is prudent to consider anesthetic plans that avoid complications associated with general or neuraxial anesthesia in patients with ALS. This case report demonstrates successful placement of a transversus abdominis plane block in a patient with ALS and offers a safe anesthetic technique that can be performed in other high-risk patients...
May 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29756238/otopathologic-evaluation-of-temporalis-fascia-grafts-following-successful-tympanoplasty-in-humans
#11
Danielle R Trakimas, Reuven Ishai, Iman Ghanad, Nicole L Black, Elliott D Kozin, Jeffrey Tao Cheng, Aaron K Remenschneider
OBJECTIVE: Temporalis fascia is a commonly used graft material in tympanoplasty; however, little is known about how the histological structure of fascia remodels postimplantation. Herein, we aim to quantify the pre- and postoperative microstructure of temporalis fascia and compare histological findings to the native tympanic membrane (TM). METHODS: Temporal bone specimens having undergone successful subtotal or total drum replacement using temporalis fascia were identified (n = 3)...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29755568/exosomes-secreted-by-normoxic-and-hypoxic-cardiosphere-derived-cells-have-anti-apoptotic-effect
#12
Helia Namazi, Iman Namazi, Parisa Ghiasi, Hassan Ansari, Sarah Rajabi, Ensiyeh Hajizadeh-Saffar, Nasser Aghdami, Elham Mohit
Cardiosphere-derived cells (CDCs) have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are required for the regenerative effects of human CDCs and mimic the cardioprotective benefits of CDCs such as anti-apoptotic effect in animal myocardial infarction (MI) models. Here we aimed to investigate the anti-apoptotic effect of the hypoxic and normoxic human CDCs-derived exosomes on induced apoptosis in human embryonic stem cell-derived cardiomyocytes (hESC-CMs). In this study, CDCs were cultured under normoxic (18% O2 ) and hypoxic (1% O2 ) conditions and CDC-exosomes were isolated from conditioned media by differential ultracentrifugation...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29755342/mitochondria-estrogen-and-female-brain-aging
#13
REVIEW
Imane Lejri, Amandine Grimm, Anne Eckert
Mitochondria play an essential role in the generation of steroid hormones including the female sex hormones. These hormones are, in turn, able to modulate mitochondrial activities. Mitochondria possess crucial roles in cell maintenance, survival and well-being, because they are the main source of energy as well as of reactive oxygen species (ROS) within the cell. The impairment of these important organelles is one of the central features of aging. In women's health, estrogen plays an important role during adulthood not only in the estrous cycle, but also in the brain via neuroprotective, neurotrophic and antioxidant modes of action...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29754274/neuroprotective-and-antinociceptive-effects-of-rosemary-rosmarinus-officinalis-l-extract-in-rats-with-painful-diabetic-neuropathy
#14
Bahram Rasoulian, Zahra Hajializadeh, Saeed Esmaeili-Mahani, Marzieh Rashidipour, Iman Fatemi, Ayat Kaeidi
Diabetes mellitus is associated with the development of neuronal tissue damage in different central and peripheral nervous system regions. A common complication of diabetes is painful diabetic peripheral neuropathy. We have explored the antihyperalgesic and neuroprotective properties of Rosmarinus officinalis L. extract (RE) in a rat model of streptozotocin (STZ)-induced diabetes. The nociceptive threshold and motor coordination of these diabetic rats was assessed using the tail-flick and rotarod treadmill tests, respectively...
May 12, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29750817/ritr-is-an-archetype-for-a-novel-family-of-redox-sensors-in-the-streptococci-that-has-evolved-from-two-component-response-regulators-and-is-required-for-pneumococcal-colonization
#15
David G Glanville, Lanlan Han, Andrew F Maule, Alexandra Woodacre, Devsaagar Thanki, Iman Tajer Abdullah, Julie A Morrissey, Thomas B Clarke, Hasan Yesilkaya, Nicholas R Silvaggi, Andrew T Ulijasz
To survive diverse host environments, the human pathogen Streptococcus pneumoniae must prevent its self-produced, extremely high levels of peroxide from reacting with intracellular iron. However, the regulatory mechanism(s) by which the pneumococcus accomplishes this balance remains largely enigmatic, as this pathogen and other related streptococci lack all known redox-sensing transcription factors. Here we describe a two-component-derived response regulator, RitR, as the archetype for a novel family of redox sensors in a subset of streptococcal species...
May 11, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29750089/comparison-of-the-effect-of-pharmacotherapy-and-neuro-feedback-therapy-on-oral-health-of-children-with-attention-deficit-hyperactivity-disorder
#16
Ali Vafaei, Iman Vafaei, Gholamreza Noorazar, Rafegh Akbarzadeh, Leila Erfanparast, Sajjad Shirazi
Background: Attention deficit hyperactivity disorder (ADHD) is a chronic and progressive mental disorder related to the childhood period. This study aims to compare the oral health of two groups of ADHD children: those under pharmacotherapy and those under neuro-feedback therapy. Material and Methods: 72 ADHD children (aged 6-12) were divided into two 36 member groups: The pharmacotherapy group and the neuro-feedback therapy group. Unstimulated salivary flow (USF), DMFT, and plaque index were assessed in these children...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29749668/signal-detection-on-a-patient-cohort-a-disproportionality-analysis-of-the-anrs-co22-hepather-cohort-to-identify-associations-between-direct-acting-antivirals-and-adverse-events-in-patients-with-hepatitis-c-virus-chronic-infection
#17
Sarah F Feldman, Nathanaël Lapidus, Céline Dorival, Alpha Diallo, Imane Amri, Hélène Fontaine, Stanislas Pol, Fabrice Carrat
No abstract text is available yet for this article.
May 11, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29747796/limited-evidence-suggests-no-benefit-of-temporomandibular-joint-lavage-over-conservative-treatment-for-temporomandibular-joint-pain-and-dysfunction
#18
Huda Fakhry, Iman Abd-Elwahab Radi
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Temporomandibular lavage versus non-surgical treatments for temporomandibular disorders: A systematic review and meta-analysis. Bouchard C, Goulet JP, El-Ouazzani M, Fournier-Turgeon A. J Oral Maxillofac Surg 2017;75:1352-62. SOURCE OF FUNDING: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors TYPE OF STUDY DESIGN: Systematic review and meta-analysis...
June 2018: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29729865/new-leadership-for-the-who-regional-office-for-the-eastern-mediterranean-exceptional-election-in-an-exceptional-time
#19
Samer Jabbour, Sameen Siddiqi, Rita Giacaman, Hani Serag, Jawad Al-Lawati, Amirhossein Takian, Habiba Ben Romdhane, Elsheikh Badr, Laith J Abu-Raddad, Aida Seif El-Dawla, Salwa Najjab, Driss Moussaoui, Mustafa Khogali, Yousef Khader, Bothaina Attal, Iman Nuwayhid
No abstract text is available yet for this article.
May 2, 2018: Lancet
https://www.readbyqxmd.com/read/29720342/-the-refeeding-syndrome-in-anorexia-nervosa
#20
Iman Badr Ibrahim, Alia Arif Hussain, Jan Magnus Sjögren
The refeeding syndrome (RFS) is a potentially fatal condition involving fluid and electrolyte imbalances after refeeding in patients with anorexia nervosa. Low-calorie diet added thiamine and minerals is the standard approach to prevent RFS. In a recent systematic review starting with a higher calorie amount than earlier has been recommended, and in another review, it is proposed that a restriction in the amount of carbohydrates may allow for a higher calorie intake early on to enable a safe and faster weight gain...
April 30, 2018: Ugeskrift for Laeger
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