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https://www.readbyqxmd.com/read/28944807/conjugated-fatty-acid-rich-oil-from-gynostrmma-pentaphyllum-seed-can-ameliorate-lipid-and-glucose-metabolism-in-type-2-diabetes-mellitus-mice
#1
Mingxing Zhang, Nan Du, Lu Wang, Xiaobing Wang, Yaping Xiao, Kun Zhang, Quanhong Liu, Pan Wang
Gynostrmma pentaphyllum seed oil (GPSO), extracted from G. pentaphyllum seeds, is rich in conjugated linolenic acid, which is a special fatty acid consisting of cis-9, trans-11, trans-13 isomers. Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from insulin resistance, and is usually accompanied by hypertension, hyperlipidemia, atherosclerosis (i.e., the metabolic syndrome, or syndrome X), and polycystic ovarian disease. This study aimed to investigate the effect of GPSO on T2DM hepatic lipid metabolism and the underlying mechanism involving level of protein expression...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944646/acute-blood-glucose-cardiovascular-and-exaggerated-responses-to-high-intensity-interval-training-and-moderate-intensity-continuous-training-in-men-with-type-2-diabetes-mellitus
#2
Shohn G Wormgoor, Lance C Dalleck, Caryn Zinn, Nigel K Harris
BACKGROUND: Optimising exercise-induced physiological responses without increasing the risk of negative exaggerated responses is an important aspect of exercise prescription for people with type 2 diabetes mellitus (T2DM). However, knowledge of acute responses, including exaggerated responses, of different training modalities is limited. AIM: To compare acute physiological responses of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) in T2DM...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944497/evolutionarily-derived-networks-to-inform-disease-pathways
#3
Britney E Graham, Christian Darabos, Minjun Huang, Louis J Muglia, Jason H Moore, Scott M Williams
Methods to identify genes or pathways associated with complex diseases are often inadequate to elucidate most risk because they make implicit and oversimplified assumptions about underlying models of disease etiology. These can lead to incomplete or inadequate conclusions. To address this, we previously developed human phenotype networks (HPN), linking phenotypes based on shared biology. However, such visualization alone is often uninterpretable, and requires additional filtering. Here, we expand the HPN to include another method, evolutionary triangulation (ET)...
September 25, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28944055/understanding-the-links-between-resilience-and-type-2-diabetes-self-management-a-qualitative-study-in-south-australia
#4
A L Wilson, D McNaughton, S B Meyer, P R Ward
BACKGROUND: Research conducted by Ward, Muller, Tsourtos, et al. (Soc Sci Med 72(7):1140-1148, 2011) has led to the development of the psycho-social interactive model of resilience, which reveals the interaction between individual resilience factors (i.e. coping, confidence and self esteem) and external resilience environments (i.e. employment, supportive family environments and health promoting policies) in facilitating the development of resilience. This present study explored the utility of this model of resilience for understanding how people self-manage type-2 diabetes...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28943876/dysbiosis-of-the-urinary-microbiota-associated-with-urine-levels-of-proinflammatory-chemokine-interleukin-8-in-female-type-2-diabetic-patients
#5
Zongxin Ling, Fengping Liu, Li Shao, Yiwen Cheng, Lanjuan Li
Evidence has shown that dysbiosis of the urinary microbiota existed in female type 2 diabetes mellitus (T2DM) patients. Perturbations of intestinal microbiota are linked to proinflammatory chemokine interleukin-8 (IL-8); however, the correlations between urinary microbiota and IL-8 are not well studied. Here, we investigated the associations between the altered urinary microbiota and urinary IL-8 in female T2DM patients. A modified four-tube midstream urine technique was used to collect urine specimens from 70 female T2DM patients and 70 matched healthy controls (HCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28943269/ramadan-fasting-in-diabetes-exercise-in-problem-solving
#6
Banshi Saboo
AIM: Appropriate management of a diabetic patient with co-morbidities, who is willing to fast during Ramadan. Case presentation A 45 year old male patient with T2DM for 5 years, current A1c of 8.3% and other co-morbidities is currently treated with metformin 500mg BID and glimepiride 2mg. During the pre-Ramadan assessment, glimepiride 2mg was changed to extended release gliclazide 60mg. It resulted in an improvement in his glycemic and microalbuminuria status without any hypoglycemic episodes...
July 29, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28942509/technology-interventions-to-manage-food-intake-where-are-we-now
#7
REVIEW
Margaret Allman-Farinelli, Luke Gemming
PURPOSE OF REVIEW: This review describes the state-of-the-art for dietary assessment using smartphone apps and digital technology and provides an update on the efficacy of technology-mediated interventions for dietary change. RECENT FINDINGS: Technology has progressed from apps requiring entry of foods consumed, to digital imaging to provide food intake data. However, these methods rely on patients being active in data collection. The automated estimation of the volume and composition of every meal consumed globally is years away...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28942507/physical-exercise-improves-heart-rate-variability-in-patients-with-type-2-diabetes-a-systematic-review
#8
REVIEW
Santos Villafaina, Daniel Collado-Mateo, Juan Pedro Fuentes, Eugenio Merellano-Navarro, Narcis Gusi
PURPOSE OF REVIEW: The aim of the present systematic review is to provide an up-to-date analysis of the research on the effects of exercise programs on heart rate variability (HRV) in individuals with type 2 diabetes mellitus (T2DM). An electronic search of the literature (PubMed, PEDro and Web of Science) was performed. "HRV", "heart rate variability", "exercise", "physical" and "diabetes" were the terms used for article retrieval. Lastly, 15 articles were selected. PRISMA methodology was employed and data were extracted according to the PICOS approach...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28942038/the-enpp1-k121q-polymorphism-modulates-developing-of-bone-disorders-in-type-2-diabetes-a-cross-sectional-study
#9
Nahid Neamati, Seyed Reza Hosseini, Mahmood Hajiahmadi, Sohrab Halalkhor, Hajighorban Nooreddini, Haleh Akhavan Niaki, Bahare Korani, Hadi Parsian
BACKGROUND: Osteoporosis and osteopenia are common diseases in every population. Type 2 diabetes mellitus (T2DM) can lead to the development of various complications, such as bone disorders especially among elderly individuals. Studies suggested that ectonucleotide pyrophosphatase/phosphodiesterase1 (ENPP1) is contributed in insulin resistance and also the inhibition of bone mineralization. In this study, association of K121Q (rs1044498) polymorphism of the ENPP1 gene with T2DM and bone disorders is evaluated...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941595/lipidome-as-a-predictive-tool-in-progression-to-type-2-diabetes-in-finnish-men
#10
Tommi Suvitaival, Isabel Bondia-Pons, Laxman Yetukuri, Päivi Pöhö, John J Nolan, Tuulia Hyötyläinen, Johanna Kuusisto, Matej Orešič
BACKGROUND: There is a need for early markers to track and predict the development of type 2 diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In this study we tested whether the plasma molecular lipidome has biomarker potential to predicting the onset of T2DM. METHODS: We applied global lipidomic profiling on plasma samples from well-phenotyped men (107 cases, 216 controls) participating in the longitudinal METSIM study at baseline and at five-year follow-up...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28941578/hypoglycaemia-in-the-over-75s-understanding-the-predisposing-factors-in-type-2-diabetes-t2dm
#11
Adrian Hugh Heald, Simon George Anderson, Gabriela Janet Cortes, Videlina Cholokova, Marcos Narajos, Adnan Khan, Gemma Donnahey, Mark Livingston
INTRODUCTION: Hypoglycaemia has been recognised as a problem in the treatment for type 2 diabetes. Here we describe how levels of HbA1C and treatment with a sulphonylurea or insulin relate to risk of significant hypoglycaemia. METHODS: Incident hypoglycaemia as recorded for the previous 10 years was determined from the GP records for patients with T2DM aged 75 years or more. RESULTS: The anonymised GP records of 5974 T2DM patients (2934 men and 3040 women) aged 75 years or more were analysed...
September 20, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28940555/serum-il-15-and-il-15r%C3%AE-levels-are-decreased-in-lean-and-obese-physically-active-humans
#12
Alberto Pérez-López, David Valadés, Clotilde Vázquez Martínez, Ana Isabel de Cos Blanco, Julia Bujan, Natalio García-Honduvilla
Circulating IL-15 presence is required to stimulate anti-adipogenic effects of the IL-15/IL-15Rα axis in adipose tissue. Although exercise increases blood IL-15 expression post-exercise, it remains inconclusive whether physical activity can alter the baseline concentrations of this cytokine. The aim of this study was to determine whether physical activity regulates circulating IL-15 and IL-15Rα in lean and obese individuals. Two hundred and seventy-six participants were divided into 5 groups according to physical activity (PA), body mass and type 2 diabetes mellitus (T2DM) diagnosis: a) lean PA (N=25); b) lean non-PA (N=28); c) obese PA (N=64), d) obese non-PA (N=79); e) obese non-PA with T2DM (N=80)...
September 20, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28939018/a-comprehensive-review-of-the-fda-approved-labels-of-diabetes-drugs-indications-safety-and-emerging-cardiovascular-safety-data
#13
Evgenia Gourgari, Vanita R Aroda, Erin E Wilhelm, Hamid Hassanzadeh, Ira Shoulson
AIMS: FDA-approved drug labels are an important source of information for clinicians who prescribe medications for treatment of diabetes. We reviewed drug labels to (1) understand the landscape of classes of medications approved for type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), (2) explore the indications and safety information and (3) examine their cardiovascular safety. METHODS: We searched four public references and reviewed all FDA-approved labels for "indication and usage," "adverse effects," "warnings and precautions," and "cardiovascular outcomes" from October 1982 to July 2016...
August 12, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28938514/-2-4-fluorobenzamido-4-methylthiazole-5-carboxylic-acid-a-novel-thiazole-compound-ameliorates-insulin-sensitivity-and-hyperlipidaemia-in-streptozotocin-induced-diabetic-rats-plausible-role-of-inflammatory-and-oxidative-stress-markers
#14
Yam Nath Paudel, Md Rahmat Ali, Mohammad Adil, Sandhya Bawa, Manju Sharma
Emerging evidence suggests that thiazole compounds are of great interest due to their protective effect against DM. Protective effects of thiazole derivatives against hyperglycemia have been demonstrated in earlier in vitro and in vivo studies. Previously, anti-oxidant and free radical scavenging activities of 2-(4-Fluorobenzamido)-4-methylthiazole-5-carboxylicacid, a newly developed thiazole derivative (NDTD), have been well-documented. Current study investigated the pharmacological effect of NDTD on hyperglycaemia, insulin sensitivity, lipid profile, anti-inflammatory and oxidative stress markers in an animal model...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938485/duodenal-sodium-glucose-co-transporter-1-expression-under-fasting-conditions-is-associated-with-post-load-hyperglycemia
#15
Teresa Vanessa Fiorentino, Evelina Suraci, Gaetano Paride Arcidiacono, Antonio Cimellaro, Chiara Mignogna, Ivan Presta, Francesco Andreozzi, Marta Letizia Hribal, Francesco Perticone, Giuseppe Donato, Francesco Luzza, Giorgio Sesti
Context: Type 2 diabetes (T2DM) is associated with a higher intestinal expression of the glucose transporters sodium/glucose co-transporter 1 (SGLT-1) and glucose transporter 2 (GLUT-2). It is currently unsettled whether prediabetes conditions characterized by post-prandial hyperglycemia, such as impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) with 1-h post-load glucose ≥155 mg/dl (8.6 mmol/l) (NGT-1h-high) are associated with increased expression of these glucose carriers in the intestine...
September 11, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937704/a-high-concentration-of-fatty-acids-induces-tnf-%C3%AE-as-well-as-no-release-mediated-by-the-p2x4-receptor-and-the-protective-effects-of-puerarin-in-raw264-7-cells
#16
Yun-Ming Tu, Cheng-Xin Gong, Lu Ding, Xing-Zi Liu, Tao Li, Fang-Fang Hu, Shuo Wang, Chao-Peng Xiong, Shang-Dong Liang, Hong Xu
Circulating levels of free fatty acids (FFAs) are often found to be increased in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). High plasma FFA levels may give rise to maladaptive macrophage activation and promote inflammatory responses, which has been proposed as a potential mechanism for the development of DM and MS. P2X4 receptor (P2X4R), a ligand-gated cation channel activated by extracellular adenosine triphosphate (ATP), plays a primary role in the regulation of inflammatory responses...
September 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28937688/diabetes-new-marker-to-predict-risk-of-t2dm
#17
David Holmes
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28937255/the-assessment-of-the-serum-c-peptide-and-plasma-glucose-levels-by-orally-administered-whey-proteins-in-type-2-diabetes-mellitus
#18
E Wildová, P Kraml, J Potočková, P Dlouhý, M Anděl
A personalized antidiabetic therapy is not yet part of the official guidelines of professional societies for clinical practice. The aim of this study was to evaluate the serum C-peptide and plasma glucose levels in patients with type 2 diabetes mellitus (T2DM) after oral administration of whey proteins. Sixteen overweight T2DM Caucasians with good glycaemic control and with preserved fasting serum C-peptide levels (> 200 nmol/l) were enrolled in this study. Two oral stimulation tests - one with 75 g of glucose (OGTT) and the other with 75 g of whey proteins (OWIST) - were administered for assessing serum C-peptide and plasma glucose levels in each participant...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28936576/improvement-of-continuous-subcutaneous-insulin-infusion-on-patients-with-type-2-diabetes-mellitus-by-3-dimensional-speckle-tracking-echocardiography
#19
Hong-Xia Luo, Xiao-Ling Zhou, Hong-Ju Kou, Xian-Wei Ni, Qing Wu, Chun-Peng Zou, Dao-Zhu Wu, Yong-Fang Liu
Three-dimensional speckle tracking echocardiography (3D-STE) was used to evaluate the improvement of continuous subcutaneous insulin infusion on the left ventricular (LV) systolic function of patients with type 2 diabetes mellitu (T2DM). We recruited T2DM patients (38 cases, diabetic group) and healthy volunteers (35 cases, control group) to collect LV full volume imaging. TomTec software was used for calculating LV global longitudinal strain (LVGLS), global circumferential strain (LVGCS), peak twist (LVTW), peak apical rotation (LVPAR), ejection fraction (LVEF), and torsion (LVT)...
September 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28936150/prevalence-of-poor-glycemic-and-blood-pressure-control-and-pattern-of-drug-use-among-primary-health-care-outpatients-in-al-ahsa-saudi-arabia
#20
Promise M Emeka, Ahmed Al Mukalaf, Hussien Al Helal, Tahir M Khan, Mishial A Almukalf
OBJECTIVES: To assess drug use pattern and the effect on glycemic and blood pressure (BP) control in type 2 diabetes mellitus (T2DM) and hypertensive patients. Furthermore, to evaluate the duration of drug use and antecedence in diagnosis. METHODOLOGY: A cross-sectional study design, comprising interview/questionnaire targeting outpatients attending primary health centers in Al Ahsa was adopted. During the interview, their fasting blood glucose, weight, and height were measured, along with their BP...
July 2017: International Journal of Health Sciences
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