keyword
MENU ▼
Read by QxMD icon Read
search

T2dm

keyword
https://www.readbyqxmd.com/read/29155328/mitochondrial-trna-leu-uur-c3275t-trna-gln-t4363c-and-trna-lys-a8343g-mutations-may-be-associated-with-pcos-and-metabolic-syndrome
#1
Yu Ding, Bo-Hou Xia, Cai-Juan Zhang, Guang-Chao Zhuo
Polycystic ovary syndrome (PCOS) is a very prevalent endocrine disease affecting reproductive women. Clinically, patients with this disorder are more vulnerable to develop type 2 diabetes mellitus (T2DM), cardiovascular events, as well as metabolic syndrome (MetS). To date, the molecular mechanism underlying PCOS remains largely unknown. Previously, we showed that mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) mutation was an important cause for PCOS. In the current study, we described the clinical and biochemical features of a three-generation pedigree with maternally transmitted MetS, combined with PCOS...
November 16, 2017: Gene
https://www.readbyqxmd.com/read/29155303/therapeutic-vaccine-against-il-1%C3%AE-improved-glucose-control-in-a-mouse-model-of-type-2-diabetes
#2
Yue Zhang, Xiao-Lin Yu, Jun Zha, Li-Zhen Mao, Jia-Qian Chai, Rui-Tian Liu
AIMS: Inflammation is strongly associated with the mechanisms of β-cell failure in type 2 diabetes. Blockade of the key proinflammatory cytokine IL-1β has been implicated as a promising therapeutic strategy for the prevention and treatment of type 2 diabetes. In this study, we developed an IL-1β-targeted therapeutic vaccine consisting of an IL-1β epitope peptide (A1β) and assessed its efficacy on a diabetic KK-A(y) mouse model. MAIN METHODS: KK-A(y) mice were immunized with A1β for three injections at a 2-week interval...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29155152/higher-prevalence-and-earlier-appearance-of-geriatric-phenotypes-in-old-adults-with-type-2-diabetes-mellitus
#3
Marina Kotsani, Thekla Chatziadamidou, Dimitrios Economides, Athanase Benetos
AIMS: To compare the prevalence of cognitive dysfunction, depression, lower mobility performance, disability and falls in older community-dwelling individuals with type 2 diabetes mellitus (T2DM) and in controls of similar age. METHODS: We conducted a cross-sectional study in primary health care settings in 3 semi-urban regions in Greece. Were assessed 403 community-dwelling older persons (age ≥65years, median: 73), 198 with and 205 without diabetes. Common geriatric syndromes were studied using structured individual interviews and widely-used screening scales...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155120/risk-of-type-2-diabetes-mellitus-associated-with-plasma-lipid-levels-the-rural-chinese-cohort-study
#4
Ming Zhang, Junmei Zhou, Yu Liu, Xizhuo Sun, Xinping Luo, Chengyi Han, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Dongsheng Hu
AIM: To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese. METHODS: Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of T2DM risk and plasma lipid levels and explore the interaction between plasma lipid levels and other risk factors. RESULTS: 11,929 participants were included in the analysis...
November 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154870/the-fto-variant-is-associated-with-chronic-complications-of-diabetes-mellitus-in-czech-population
#5
Jaroslav A Hubacek, Dana Dlouha, Marta Klementova, Vera Lanska, Tomas Neskudla, Terezie Pelikanova
BACKGROUND: Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications. METHODS: Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2339 individuals) - both of Czech origin - were genotyped for the FTO rs17817449 SNP...
November 14, 2017: Gene
https://www.readbyqxmd.com/read/29154443/long-term-outcomes-of-patients-with-type-2-diabetes-attending-a-multidisciplinary-diabetes-kidney-disease-clinic
#6
Serena Low, Su Chi Lim, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Eng Kuang Lim, Yan Li Shao, Winnie Chui, Sharon Fun, Chin Lian Chua, Tavintharan Subramaniam, Chee Fang Sum
BACKGROUND: The best model of care to retard diabetic kidney disease (DKD) in the clinic is under-unexplored. We investigated the long-term renal outcomes of a joint endocrinologist-nephrologist clinic. METHODS: This was a nested case-control study derived from a cohort of patients with type 2 diabetes mellitus (T2DM) seen prospectively at a secondary care Diabetes Centre (DC). Cases ("DKD clinic group") are patients seen at the CKD clinic after being referred by physicians in DC for management of DKD...
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29153226/relationship-between-person-s-health-beliefs-and-diabetes-self-care-management-regimen
#7
Moudi Albargawi, Julia Snethen, Abdulaziz Al Gannass, Sheryl Kelber
PURPOSE: To examine the relationship between the health beliefs of Saudi adults with type 2 diabetes mellitus (T2DM) and their adherence to daily diabetes self-care management regimen. A secondary aim was to examine the health beliefs of adults with a diabetic foot ulcer (DFU) and participants without a DFU. METHOD: Descriptive correlational design with a convenience sample of 30 participants. Participants were recruited for this pilot study from an outpatient clinic at King Abdulaziz Medical City in Riyadh...
December 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29152661/apolipoprotein-status-in-type-2-diabetes-mellitus-and-its-complications-review
#8
Puhong Zhang, Jialin Gao, Chun Pu, Yao Zhang
Dyslipidaemia in type 2 diabetes mellitus (T2DM) is characterized by high plasma triglyceride concentrations, reduced high‑density lipoprotein concentrations and increased small density low‑density lipoprotein concentrations. Dyslipidaemia may lead to cardiovascular disease (CVD) and other complications. Apolipoproteins mainly comprise six species, apolipoprotein (apo)A, apoB, apoC, apoD, apoE and apoM, which are important components of plasma lipoproteins that carry lipids and stabilize the structure of lipoproteins...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29152139/igf1-gene-polymorphisms-associated-with-diabetic-retinopathy-risk-in-chinese-han-population
#9
Jian Zhang, Xiao Chen, Like Zhang, Yi Peng
Objective: This study aimed to explore the association of insulin-like growth factor 1 gene (IGF1) polymorphisms with diabetic retinopathy (DR) in a Chinese Han population. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. Genotype frequencies were compared by chi-square test. Odds ratio (OR) with 95% confidence interval (95%CI) was calculated to express the risk intensity of DR. Linkage disequilibrium between IGF1 polymorphisms was analyzed by Haploview...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151334/investigation-of-glucocorticoid-receptor-and-calpain-10-gene-polymorphisms-in-turkish-patients-with-type-2-diabetes-mellitus
#10
Naciye Selcen Bayramcı, Leyla Açık, Çağdaş Kalkan, İlhan Yetkin
Background/aim: We proposed to investigate the role of calpain-10 (CAPN10) gene single nucleotide polymorphism (SNP)-19 and SNP-44 and glucocorticoid receptor (NR3C1) gene N363S polymorphisms in Turkish patients with type 2 diabetes mellitus (T2DM).Materials and methods: Peripheral blood samples were obtained from 125 patients with T2DM and 112 healthy volunteers. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There were no statistically significant differences found between the allele and genotype frequencies of CAPN10 SNP-19, CAPN10 SNP-44, and NR3C1 N363S polymorphisms and T2DM development (P > 0...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151315/effect-of-treatment-of-iron-deficiency-anemia-onhemoglobin-a1c-in-type-2-diabetic-patients
#11
Ensieh Naslı-Esfahani, Bagher Larijani, Peyvand Amini, Robabeh Ghodssi-Ghassemabadi, Rezvan Razmandeh
Background/aim: Iron deficiency anemia (IDA) affects hemoglobin A1c (HbA1c) levels. This study aimed to evaluate the effect of treatment of iron deficiency anemia on hemoglobin A1c in type 2 diabetic patients.Materials and methods: Ninety type 2 diabetes mellitus (T2DM) patients with IDA were included in a randomized, placebo-controlled, single-blind clinical trial. The intervention group (n = 45) received 200 mg/day oral iron for 3 months and the control group (n = 45) received an oral placebo for the same period...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151224/the-potential-role-of-the-osteopontin-osteocalcin-osteoprotegerin-triad-in-the-pathogenesis-of-prediabetes-in-humans
#12
Giuseppe Daniele, Deidre Winnier, Andrea Mari, Jan Bruder, Marcel Fourcaudot, Zuo Pengou, Andrea Hansis-Diarte, Christopher Jenkinson, Devjit Tripathy, Franco Folli
AIMS: To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes. METHODS: Individuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m(2)) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m(2)) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin (OCN), osteoprotegerin (OPG), and PTH levels were measured at fasting...
November 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29151065/the-mrna-expression-levels-of-uncoupling-proteins-1-and-2-in-mononuclear-cells-from-patients-with-metabolic-disorders-obesity-and-type-2-diabetes-mellitus
#13
Sona Margaryan, Agata Witkowicz, Anna Partyka, Levon Yepiskoposyan, Gayane Manukyan, Lidia Karabon
INTRODUCTION: Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders whose major hallmark is insulin resistance. Impaired mitochondrial activity, such as reduced ratio of energy production to respiration, has been implicated in the development of insulin resistance. Uncoupling proteins (UCPs) are proton carriers, expressed in the mitochondrial inner membrane, that uncouple oxygen consumption by the respiratory chain from ATP synthesis. AIM: The aim of the study was to determine transcriptional levels of UCP1 and UCP2 in peripheral blood mononuclear cells (PBMCs) from patients with metabolic disorders: T2DM, obesity and from healthy individuals...
October 19, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29151018/study-of-the-nlrp3-inflammasome-component-genes-and-downstream-cytokines-in-patients-with-type-2-diabetes-mellitus-with-carotid-atherosclerosis
#14
Junli Lee, Jing Wan, Linyun Lee, Changhua Peng, Hailong Xie, Chengbin Lee
BACKGROUND: A role for the NLRP3 inflammasome has been reported in various diseases, such as diabetes mellitus, atherosclerosis (AS), nephropathy, rheumatism, and others, although limited information is available concerning the role of the NLRP3 inflammasome, interleukin-1β (IL-1β) and interleukin-18 (IL-18) in patients with type 2 diabetes mellitus (T2DM) and carotid atherosclerosis (CAS). Therefore, this cross-sectional study investigated these inflammatory components in patients with T2DM complicated with carotid atherosclerosis (T2DM + CAS)...
November 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29150850/comparison-of-pharmacodynamic-effects-of-ticagrelor-vs-prasugrel-in-type-2-diabetes-mellitus-patients-with-coronary-heart-disease
#15
L-L Shang, D-D Guo, H-Y Zhao, A-J Quan, P-G Cao
WHAT IS KNOWN AND OBJECTIVE: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of thrombotic complications. Studies have indicated that patients with T2DM have impaired clopidogrel-induced antiplatelet effect. Ticagrelor and prasugrel are two latest generation P2Y12 inhibitors with advantageous platelet inhibitory profiles. However, the pharmacodynamic differences between the two drugs in patients with T2DM remain poorly explored. METHODS: This study, involving 140 patients with T2DM following percutaneous coronary intervention (PCI), evaluated the efficacy of aspirin upon concomitant use of prasugrel (10 mg/d) or ticagrelor (90 mg/d)...
November 17, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29150631/effect-of-long-term-incretin-based-therapies-on-ischemic-heart-diseases-in-patients-with-type-2-diabetes-mellitus-a-network-meta-analysis
#16
Che-Yi Chou, Ying-Tzu Chang, Jia-Lian Yang, Jiun-Yi Wang, Tsui-Er Lee, Ruey-Yun Wang, Chin-Chuan Hung
Patients with type 2 diabetes mellitus (T2DM) experience many cardiovascular complications. Several studies have demonstrated the cardioprotective effects of incretin-based therapies; however, there are few studies on the effects of long-term incretin-based therapies on cardiovascular events. Therefore, the present study conducted a systematic review and network meta-analysis to evaluate the effects of long-term incretin-based therapies on ischaemic diseases. We searched PubMed, CENTRAL, and Clinicaltrial.gov to retrieve randomised control trials reported until December 2016 and enrolled only RCTs with more than a 1-year follow-up...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29147909/the-role-of-the-antioxidant-protein-dj-1-in-type-2-diabetes-mellitus
#17
Daniel Eberhard, Eckhard Lammert
Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder resulting from insulin resistance and functional loss of insulin-producing beta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, endoplasmic reticulum stress, and streptozotocin- and cytokine-induced stress and preserves beta cell viability and insulin secretion...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29147664/reduced-inspiratory-muscle-strength-in-patients-with-type-2-diabetes-mellitus-and-obstructive-sleep-apnoea
#18
Thomas Rehling, Anne Margareta Banghøj, Marie Hvelplund Kristiansen, Lise Tarnow, Stig Molsted
Background: Obstructive sleep apnoea (OSA) is related to type 2 diabetes (T2DM), and it may be associated with reduced inspiratory muscle strength (IMS). The aim of this study was to investigate the IMS in patients with T2DM, with or without OSA. Methods: Patients with T2DM with OSA (n = 33) and without OSA (n = 28) were included. The maximum IMS was tested using the POWERbreathe KH2 device. Reference IMS values were data calculated using an algorithm based on general populations and adjusted for age and gender...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29147551/development-of-proteolytically-stable-n-methylated-peptide-inhibitors-of-aggregation-of-the-amylin-peptide-implicated-in-type-2-diabetes
#19
Idira Obasse, Mark Taylor, Nigel J Fullwood, David Allsop
Islet amyloid polypeptide, also known as amylin, is the main component of the amyloid deposits present in approximately 90% of people with type 2 diabetes mellitus (T2DM). In this disease, amylin aggregates into multimeric β-pleated sheet structures which cause damage to pancreatic islet β-cells. Inhibitors of early-stage amylin aggregation could therefore provide a disease-modifying treatment for T2DM. In this study, overlapping peptides were designed to target the 'binding' region (RLANFLVHSS, residues 11-20) of human amylin, and their effects on amyloid fibril formation were determined by thioflavin-T assay...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147492/alterations-in-adult-hippocampal-neurogenesis-aberrant-protein-s-nitrosylation-and-associated-spatial-memory-loss-in-streptozotocin-induced-diabetes-mellitus-type-2-mice
#20
Aneeqa Noor, Saadia Zahid
Objectives: Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible molecular links between T2DM and AD, the present study investigated the status of neurodegeneration, adult hippocampal neurogenesis, and nitrosative stress induced protein S-nitrosylation in streptozotocin (STZ) induced mice models of T2DM...
October 2017: Iranian Journal of Basic Medical Sciences
keyword
keyword
44982
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"