Veena S Rao, Juan B Ivey-Miranda, Zachary L Cox, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Daniel Neville, Natasha Balkcom, Jennifer L Asher, Lavanya Bellumkonda, Tamar Bigvava, Tamaz Shaburishvili, Jozef Bartunek, F Perry Wilson, Fredrick Finkelstein, Christopher Maulion, Jeffrey M Turner, Jeffrey M Testani
AIMS: Loop diuretics may exacerbate cardiorenal syndrome (CRS) in heart failure (HF). Direct sodium removal (DSR) using the peritoneal membrane, in conjunction with complete diuretic withdrawal, may improve CRS and diuretic resistance. METHODS AND RESULTS: Patients with HF requiring high-dose loop diuretics were enrolled in two prospective, single-arm studies: RED DESERT (n = 8 euvolaemic patients), and SAHARA (n = 10 hypervolaemic patients)...
March 31, 2024: European Journal of Heart Failure