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https://www.readbyqxmd.com/read/29684380/sustained-or-higher-levels-of-growth-factors-in-platelet-rich-plasma-during-7-day-storage
#1
Ying-Hao Wen, Wan-Ying Lin, Chi-Jui Lin, Yu-Chen Sun, Pi-Yueh Chang, Hsin-Yao Wang, Jang-Jih Lu, Wen-Lin Yeh, Tzong-Shi Chiueh
BACKGROUND: The effectiveness of platelet-rich plasma (PRP) for treating soft tissue injuries is still controversial. Most of PRPs were prepared simply by concentrating in volume and were injected right after preparation in physician offices. Neither platelet count nor growth factors were quantitated in advance. We prepared and stored leukocyte and platelet-rich plasma (L-PRP) by regular separation protocols for blood components in the blood bank. And we investigated the dynamic change of growth factors in the L-PRPs over the period of storage...
April 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29680817/relationships-between-plasma-insulin-like-growth-factor-1-and-insulin-concentrations-in-multiparous-dairy-cows-with-cytological-endometritis
#2
Merle Valdmann, Jevgeni Kurykin, Tanel Kaart, Gret-Kristel Mällo, Andres Waldmann
Cytological endometritis (CYTO) is a uterine inflammation characterised by the percentage of polymorphonuclear neutrophils in endometrial cytology. This observational study evaluated the association of blood plasma insulin-like growth factor-1 (IGF-1) and insulin concentrations at -2 weeks prepartum, +1 week and +3 weeks postpartum with the development of CYTO in 119 multiparous Holstein cows. Overall CYTO prevalence was 30.3 per cent. Multivariable logistic regression model revealed the odds of developing CYTO were 3...
April 21, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29679919/the-effect-of-growth-hormone-on-bioactive-igf-in-overweight-obese-women
#3
Laura E Dichtel, Mette Bjerre, Melanie Schorr, Miriam A Bredella, Anu V Gerweck, Brian M Russell, Jan Frystyk, Karen K Miller
OBJECTIVE: Overweight/obesity is characterized by decreased growth hormone (GH) secretion whereas circulating IGF-I levels are less severely reduced. Yet, the activity of the circulating IGF-system appears to be normal in overweight/obese subjects, as estimated by the ability of serum to activate the IGF-I receptor in vitro (bioactive IGF). We hypothesized that preservation of bioactive IGF in overweight/obese women is regulated by an insulin-mediated suppression of IGF-binding protein-1 (IGFBP-1) and IGFBP-2, and by suppression of IGFBP-3, mediated by low GH...
March 10, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29679075/apkc%C3%AE-dependent-repression-of-yap-is-necessary-for-functional-restoration-of-irradiated-salivary-glands-with-igf-1
#4
Alejandro M Chibly, Wen Yu Wong, Maricela Pier, Hongqiang Cheng, Yongxin Mu, Ju Chen, Sourav Ghosh, Kirsten H Limesand
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of effective treatments for radiation-induced salivary hypofunction, stem cell-based therapies have been suggested to regenerate the irradiated salivary glands. Pharmacologically, restoration of salivary gland function has been accomplished in mice by administering IGF-1 shortly after radiation treatment, but it is not known if salivary stem and progenitor cells play a role...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678421/growth-hormone-receptor-deficient-pigs-resemble-the-pathophysiology-of-human-laron-syndrome-and-reveal-altered-activation-of-signaling-cascades-in-the-liver
#5
Arne Hinrichs, Barbara Kessler, Mayuko Kurome, Andreas Blutke, Elisabeth Kemter, Maren Bernau, Armin M Scholz, Birgit Rathkolb, Simone Renner, Sebastian Bultmann, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Hiroshi Nagashima, Andreas Hoeflich, Werner F Blum, Martin Bidlingmaier, Rüdiger Wanke, Maik Dahlhoff, Eckhard Wolf
OBJECTIVE: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were generated and characterized. METHODS: CRISPR/Cas9 technology was applied to mutate exon 3 of the GHR gene in porcine zygotes. Two heterozygous founder sows with a 1-bp or 7-bp insertion in GHR exon 3 were obtained, and their heterozygous F1 offspring were intercrossed to produce GHR-KO, heterozygous GHR mutant, and wild-type pigs...
March 15, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29678281/an-orphan-g-protein-coupled-receptor-causes-human-gigantism-and-or-acromegaly-molecular-biology-and-clinical-correlations
#6
REVIEW
Giampaolo Trivellin, Laura C Hernández-Ramírez, Jeremy Swan, Constantine A Stratakis
X-linked acrogigantism (X-LAG) is a recently described form of familial or sporadic pituitary gigantism characterized by very early onset GH and IGF-1 excess, accelerated growth velocity, gigantism and/or acromegaloid features. Germline or somatic microduplications of the Xq26.3 chromosomal region, invariably involving the GPR101 gene, constitute the genetic defect leading to X-LAG. GPR101 encodes a class A G protein-coupled receptor that activates the 3',5'-cyclic adenosine monophosphate signaling pathway...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29677634/physiological-variations-in-reproductive-and-metabolic-features-of-white-tailed-deer-odocoileus-virginianus-bucks-throughout-the-rutting-season
#7
Jamie L Stewart, Clifford F Shipley, Robyn E Ellerbrock, Lauren Schmidt, Fabio S Lima, Igor F Canisso
White-tailed deer farming is a growing industry in the United States, yet there is still a need to improve breeding practices in captive cervids. The objective of this study was to compare reproductive and somatic characteristics of white-tailed bucks early in the breeding season (September), at peak rut (December), and late breeding season (March). We hypothesized that reproductive parameters would improve at the peak of the breeding season. Young, mature bucks (n = 7-11, ages 2-3 yr) were anesthetized via projector with tiletamine-zolazepam and xylazine...
April 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29675290/diagnostic-and-immunosuppressive-potential-of-elevated-mir-424-levels-in-circulating-immune-cells-of-ischemic-stroke-patients
#8
Guangwen Li, Qingfeng Ma, Rongliang Wang, Zhibin Fan, Zhen Tao, Ping Liu, Haiping Zhao, Yumin Luo
Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients with acute ischemic stroke (AIS). Blood samples were collected from 40 patients within 6 hours of symptom onset and 27 control subjects. MiR-424 levels in lymphocytes, neutrophils and plasma were determined by quantitative realtime-PCR...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29673244/changes-in-body-composition-blood-lipid-profile-and-growth-factor-hormone-in-a-patient-with-prader-willi-syndrome-during-24-weeks-of-complex-exercise-a-single-case-study
#9
Hee Joung Joung, In Soo Lim
PURPOSE: Prader-Willi syndrome (PWS) is a genetic disorder characterized by excessive appetite with progressive obesity and growth hormone (GH) deficiency. Excessive eating causes progressive obesity with increased risk of morbidities and mortality. Although GH treatment has beneficial effects on patients with PWS, adverse events have occurred during GH treatment. Exercise potentially has a positive effect on obesity management. The purpose of this research was to examine the effects of 24-week complex exercise program on changes in body composition, blood lipid profiles, and growth factor hormone levels in a patient with PWS...
March 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29672904/growth-hormone-gh-insulin-like-growth-factor-1-igf-1-axis-hyperactivity-on-bone-fibrous-dysplasia-in-mccune-albright-syndrome
#10
Daniele Tessaris, Alison M Boyce, Margaret Zacharin, Patrizia Matarazzo, Roberto Lala, Luisa de Sanctis, Michael T Collins
CONTEXT: In fibrous dysplasia (BFD) normal bone and bone marrow are replaced by fibro-osseous tissue, leading to fracture, deformity and pain. BFD may be isolated, or in association with cutaneous hyperpigmentation and/or hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). GH hypersecretion has been described in 10-20% of MAS-BFD patients. Aim of the study is to determine the impact of GH-insulin like growth factor 1 (IGF1) axis hyperactivity on MAS-BFD morbidities and the efficacy of GH excess therapy...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29672153/p21-activated-kinase4-in-pancreatic-acini-is-activated-by-gi-hormones-growth-factors-by-novel-signaling-and-is-needed-to-stimulate-secretory-growth-cascades
#11
Irene Ramos-Alvarez, Robert T Jensen
p21-activated kinases(PAKs) are highly conserved serine/threonine protein kinases, which are divided into two groups:Group-I(PAKs1-3) and Group-II(PAKs4-6). In various tissues, Group-II PAKs play important roles in cytoskeletal dynamics, cell growth as well as neoplastic development/progression. However, little is known about Group-II PAKs role in a number of physiological events including their ability to be activated by gastrointestinal(GI) hormones/neurotransmitters/growth-factors(GFs). We used rat pancreatic acini to explore the ability of GI-hormones/neurotransmitters/GFs to activate Group-II-PAKs and the signaling cascades involved...
April 19, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29671767/effects-of-whey-protein-hydrolysate-ingestion-on-postprandial-aminoacidemia-compared-with-a-free-amino-acid-mixture-in-young-men
#12
Kyosuke Nakayama, Chiaki Sanbongi, Shuji Ikegami
To stimulate muscle protein synthesis, it is important to increase the plasma levels of essential amino acids (EAA), especially leucine, by ingesting proteins. Protein hydrolysate ingestion can induce postprandial hyperaminoacidemia; however, it is unclear whether protein hydrolysate is associated with higher levels of aminoacidemia compared with a free amino acid mixture when both are ingested orally. We assessed the effects of whey protein hydrolysate (WPH) ingestion on postprandial aminoacidemia, especially plasma leucine levels, compared to ingestion of a free amino acid mixture...
April 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29671256/effects-of-growth-hormone-on-pregnancy-rates-of-patients-with-thin-endometrium
#13
N Cui, A-M Li, Z-Y Luo, Z-M Zhao, Y-M Xu, J Zhang, A-M Yang, L-L Wang, G-M Hao, B-L Gao
PURPOSE: To investigate whether growth hormone (GH) could improve pregnancy rates of patients with thin endometrium by clinical study and laboratory experiments. MATERIALS AND METHODS: Ninety-three patients were randomized to either the GH-received group (40) or the routine exogenous administration of estrogens control group (53) for clinical study. The human endometrial carcinoma cell line RL95-2 was used for testing the role of GH with Western blot and real-time PCR by exposure to various concentrations of GH (0...
April 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29671202/pharmacokinetics-and-pharmacodynamics-of-once-weekly-somapacitan-in-children-and-adults-supporting-dosing-rationales-with-a-model-based-analysis-of-three-phase-i-trials
#14
Rasmus Vestergaard Juul, Michael Højby Rasmussen, Henrik Agersø, Rune Viig Overgaard
BACKGROUND: Somapacitan, a long-acting growth hormone (GH) derivative, has been well-tolerated in children with GH deficiency (GHD) and adults (healthy and adult GHD), in phase I, single- and multiple-dose trials, respectively, and has pharmacokinetic and pharmacodynamic properties supporting a once-weekly dosing regimen. OBJECTIVE: In the absence of a multiple-dose phase I trial in children with GHD, the aim was to develop a pharmacokinetic/pharmacodynamic model to predict somapacitan exposure and insulin-like growth factor-I (IGF-I) response after once-weekly multiple doses in both children and adults with GHD...
April 18, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29670907/improvement-activity-of-1-deoxynojirimycin-in-the-growth-of-dairy-goat-primary-mammary-epithelial-cell-through-upregulating-lef-1-expression
#15
Shengyue Ji, Ming Liu, Yuping Zhang, Hongfu Zhang
LEF-1/wnt10b is one of the most important signaling pathways regulating mammary gland growth and development and is also a potential target for molecular breeding. In this work, 1-deoxynojirimycin (DNJ), a natural alkaloid extracted from plant mulberry or microorganism, was found to have a positive activity in primary breast epithelial cell growth of dairy goats. The findings showed that, compared to the control, 6  μ M DNJ in the DMEM/F12 medium in vitro greatly improved the density of dairy goat breast epithelial cell and significantly increased the LEF-1 mRNA level ( P < 0...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29670680/gengnianchun-extends-the-lifespan-of-caenorhabditis-elegans-via-the-insulin-igf-1-signalling-pathway
#16
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against A β -induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans . However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29669759/multi-kinase-inhibitor-ct-707-targets-liver-cancer-by-interrupting-the-hypoxia-activated-igf-1r-yap-axis
#17
Hong Zhu, Dan-Dan Wang, Tao Yuan, Fang-Jie Yan, Chen-Ming Zeng, Xiao-Yang Dai, Zi-Bo Chen, Ying Chen, Tianyi Zhou, Guang-Han Fan, Meidan Ying, Ji Cao, Peihua Luo, Xi-Jie Liu, Yuandong Hu, Yong Peng, Qiaojun He, Bo Yang
Given that YAP signaling acts as a critical survival input for hypoxic cancer cells in hepatocellular carcinoma (HCC), disruption of YAP function and the maintenance of hypoxia is an attractive way to treat HCC. Utilizing a cell-based YAP-TEAD luciferase reporter assay and functional analyses, we identified CT-707, a China-FDA approved multi-kinase inhibitor under clinical trial with remarkable inhibitory activity against YAP function. CT-707 exhibited prominent cytotoxicity under hypoxia on HCC cells, which was attributable to the inhibition of YAP signaling...
April 18, 2018: Cancer Research
https://www.readbyqxmd.com/read/29669302/cytotoxic-and-partial-hepatoprotective-activity-of-sodium-ascorbate-against-hepatocellular-carcinoma-through-inhibition-of-sulfatase-2-in-vivo-and-in-vitro
#18
Abdullah Alyoussef, Mohammed M H Al-Gayyar
Hepatocellular carcinoma (HCC) is characterized by elevation in the activity of sulfatase-2, an extracellular enzyme that catalyzes removal of 6-O-sulfate groups from heparan sulfate. Therefore, we conducted this study to investigate the cytotoxic activity of the strong water-soluble antioxidant, sodium ascorbate, against HCC both in vivo and in vitro. Sodium ascorbate enhanced animal survival in vivo and reduced HepG2 cells survival. The protein levels of heparan sulfate proteoglycans (HSPGs), insulin like growth factor (IGF)-2, sulfatase-2 and glypican-3 were assessed...
April 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29668981/wnts-role-in-bovine-folliculogenesis-and-estrogen-production
#19
B I Gomez, B H Aloqaily, C A Gifford, D M Hallford, J A Hernandez Gifford
Appreciation of mechanisms that affect steroidogenesis is critical to identifying compromising signals that may decrease reproductive efficiency. Follicle maturation and steroidogenesis requires coordinated actions from the pituitary gonadotropins, and local ovarian signaling molecules. Beta-catenin (CTNNB1), the lynchpin molecule of canonical wingless-type mouse mammary tumor virus integration site (WNT) signaling is required for maximal gonadotropin stimulation of steroid production from granulosa (GC) and luteal cells...
April 13, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29668890/luteinizing-hormone-facilitates-antral-follicular-maturation-and-survival-via-thecal-paracrine-signaling-in-cattle
#20
Katsushige Hattori, Makoto Orisaka, Shin Fukuda, Kimihisa Tajima, Yukiko Yamazaki, Tetsuya Mizutani, Yoshio Yoshida
The use of LH supplementation in assisted reproductive technology (ART) cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral follicles, we used an in vitro two-cell system that involved co-culturing bovine granulosa cells (GC) and theca cells (TC) on a collagen membrane. Treatment of TC with LH stimulated androgen production in TC by inducing the expression of androgenic factors, subsequently increasing estrogen biosynthesis in GC by providing androgen substrates and inducing aromatase expression...
April 13, 2018: Endocrinology
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