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Jun Luo, Hehe Liu, Jiwen Wang, Liang Li, Chunchun Han, Xinmeng Gan, Yanying Li, Lili Bai, Ahsan Mustafa
As a central immune organ unique to birds, the bursa of Fabricius (BF) provides a proper microenvironment for B-cell development. The bursal B-cells undergo rapid proliferation and differentiation at the embryonic stages, but 95% of them undergo apoptosis after hatching. Few studies have focused on the cause of bursal B-cells apoptosis at the embryonic stages in birds. To explore the cause, we compared the transcriptional profiles of three characteristic embryonic stages in duck, including embryonic day 14 (ED14), 22 (ED22) and 1 day after hatching (D1)...
June 19, 2018: Molecular Immunology
Sameer A Greenall, Jacqueline Donoghue, Terrance G Johns, Timothy E Adams
Hepatocellular carcinoma (HCC) is highly refractory to current therapeutics used in the clinic. DX-2647, a recombinant human antibody, potently neutralizes the action of insulin-like growth factor-II (IGF-II), a ligand for three cell-surface receptors (IGF-IR, insulin receptor A and B isoforms, and the cation-independent mannose-6-phosphate receptor) which is overexpressed in primary human HCC. DX-2647 impaired the growth of tumor xenografts of the HCC cell line, Hep3B; however, xenografts of the HCC cell line, HepG2, were largely unresponsive to DX-2647 treatment...
June 18, 2018: Translational Oncology
Maria Papageorgiou, Daniel Martin, Hannah Colgan, Simon Cooper, Julie P Greeves, Jonathan C Y Tang, William D Fraser, Kirsty J Elliott-Sale, Craig Sale
PURPOSE: We aimed to explore the effects of low energy availability (EA)[15 kcal·kg lean body mass (LBM)-1 ·d-1 ] achieved by diet or exercise on bone turnover markers in active, eumenorrheic women. METHODS: By using a crossover design, ten eumenorrheic women (VO2 peak : 48.1 ± 3.3 ml·kg-1 ·min-1 ) completed all three, 3-day conditions in a randomised order: controlled EA (CON; 45 kcal·kgLBM-1 ·d-1 ), low EA through dietary energy restriction (D-RES; 15 kcal·kgLBM-1 ·d-1 ) and low EA through increasing exercise energy expenditure (E-RES; 15 kcal·kgLBM-1 ·d-1 ), during the follicular phase of three menstrual cycles...
June 19, 2018: Bone
Georgios Vassilakos, Hanqin Lei, Yun Yang, Jason Puglise, Michael Matheny, Julia Durzynska, Matan Ozery, Katherine Bennett, Ray Spradlin, Heather Bonanno, Soohyun Park, Rexford S Ahima, Elisabeth R Barton
Insulin-like growth factors (IGFs) are essential for local skeletal muscle growth and organismal physiology, but these actions are entwined with glucose homeostasis through convergence with insulin signaling. The objective of this work was to determine whether the effects of IGF-I on growth and metabolism could be separated. We generated muscle-specific IGF-I-deficient (MID) mice that afford inducible deletion of Igf1 at any age. After Igf1 deletion at birth or in young adult mice, evaluations of muscle physiology and glucose homeostasis were performed up to 16 wk of age...
June 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Sheila Vilarindo de Sousa, Marcos Jácome de Araújo, Tairon Panunzio Dias E Silva, Carlo Aldrovandi Torreão Marques, Jacira Neves da Costa Torreão, Leilson Rocha Bezerra, Isak Samir de Sousa Lima, Fernanda Patrícia Gottardi
The aim of this study was to evaluate the impact of different levels of dietary supplementation and reproductive stages on dry matter intake, digestibility, milk production, and mineral metabolism in Santa Inês hair ewes. Two dietary supplement levels of 0.5 and 1.5%, based on body weight, were used. A total of 12 hair ewes (six subjected to 0.5 and six subjected to 1.5% of concentrate supplementation based on body weight-BW) of the Santa Inês breed were evaluated in a completely randomized design with fixed effects of supplementation level, period, and its interactions...
June 22, 2018: Tropical Animal Health and Production
Xiaopeng Guo, Yumo Zhao, Man Wang, Lu Gao, Zihao Wang, Zhuhua Zhang, Bing Xing
PURPOSE: To evaluate the incidence of obstructive sleep apnea-hypopnea syndrome (OSAHS), explore the structural changes in pharyngeal soft tissue underlying OSAHS development and analyze the correlation between hormone levels and pharyngeal soft tissue changes in patients with untreated acromegaly. METHODS: Twenty-five patients with untreated acromegaly were prospectively enrolled. Pituitary hormones were tested, sellar magnetic resonance imaging was confirmed, overnight polysomnography was conducted, and upper airway computed tomography was performed on these patients...
June 21, 2018: Endocrine
Gabor A Fulop, Francisco I Ramirez-Perez, Tamas Kiss, Stefano Tarantini, Marta Noa Valcarcel Ares, Peter Toth, Andriy Yabluchanskiy, Shannon M Conley, Praveen Ballabh, Luis A Martinez-Lemus, Zoltan Ungvari, Anna Csiszar
No abstract text is available yet for this article.
June 21, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
M Buzzi, P Versura, B Grigolo, C Cavallo, A Terzi, M Pellegrini, G Giannaccare, V Randi, E C Campos
INTRODUCTION: Various blood-derived products have been proposed for the topical treatment of ocular surface diseases. The aim of the study was to compare the different content of Growth Factors (GFs) and Interleukins (ILs) in peripheral blood (PB-S) and Cord Blood (CB-S) sera. MATERIALS AND METHODS: Sera were obtained from 105 healthy adult donors (PB-S) and 107 umbilical/placental veins at the time of delivery (CB-S). The levels of epithelial-GF (EGF), fibroblast-GF (FGF), platelet-derived-GF (PDGF), insulin-GF (IGF), transforming-GF alpha (TGF-α,) and beta 1-2-3 (TGF-β1-β2-β3), vascular endothelial-GF (VEGF), nerve-GF (NGF), Interleukin (IL)-1β,IL-4,IL-6,IL-10, and IL-13 were assessed by Bio-Plex Protein Array System (Bio-Rad Laboratories, CA, USA)...
June 13, 2018: Transfusion and Apheresis Science
Heba A Metwaly, Amal M El-Gayar, Mamdouh M El-Shishtawy
AIM OF WORK: The study was conducted for evaluation of the antitumor activity of SSTN92-119 against HCC induced by thioacetamide in rats. METHODS: Sixty male Sprague-Dawley rats were randomized into four equal groups: Control, SSTN92-119 , HCC, and HCC + SSTN92-119 . Liver function tests were measured in serum. Liver homogenate was used for determination of: i) integrinαѴβ3 (ITGαѴβ3), insulin like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2) and alpha-fetoprotein (AFP) levels by ELISA, ii) syndecan-1 (CD-138), IGF-1R and VEGF genes expressions by qRT-PCR, iii) MDA, NO, GSH concentrations and SOD activity...
June 18, 2018: Archives of Biochemistry and Biophysics
Lu Zhang, Cuihua Feng, Yamin Zhou, Qiong Zhou
The present study aimed to identify bladder cancer-associated microRNAs (miRNAs) and target genes, and further analyze the potential molecular mechanisms involved in bladder cancer. The mRNA and miRNA expression profiling dataset GSE40355 was downloaded from the Gene Expression Omnibus database. The Limma package in R was used to identify differential expression levels. The Human microRNA Disease Database was used to identify bladder cancer-associated miRNAs and Target prediction programs were used to screen for miRNA target genes...
June 2018: Oncology Letters
Antti P Aalto, Ian A Nicastro, James P Broughton, Laura B Chipman, William P Schreiner, Jerry S Chen, Amy E Pasquinelli
Argonaute (AGO) proteins partner with microRNAs (miRNAs) to target specific genes for post-transcriptional regulation. During larval development in Caenorhabditis elegans, Argonaute-Like Gene 1 (ALG-1) is the primary mediator of the miRNA pathway, while the related ALG-2 protein is largely dispensable. Here we show that in adult C. elegans these AGOs are differentially expressed and, surprisingly, work in opposition to each other; alg-1 promotes longevity, whereas alg-2 restricts lifespan. Transcriptional profiling of adult animals revealed that distinct miRNAs and largely non-overlapping sets of protein-coding genes are misregulated in alg-1 and alg-2 mutants...
June 2018: PLoS Genetics
Håvard Hamarsland, Gøran Paulsen, Paul A Solberg, Ole Gunnar Slaathaug, Truls Raastad
INTRODUCTION: The aim of this study was to investigate the effect of an arduous one-week military course on measures of physical performance, body composition and blood biomarkers. METHODS: Participants were apprentices in an annual selection course for the Norwegian Special Forces. Fifteen soldiers (23±4 yrs., 1.81±0.06 m, 78±7 kg) completed a hell-week consisting of rigorous activity only interspersed by 2-3 hours of sleep per day. Testing was conducted before and 0, 1, 3, 7 and 14 days after the hell-week...
June 21, 2018: Medicine and Science in Sports and Exercise
Hong-Fang Yang, Xiao-Jing Lin, Xiao-Hui Wang
OBJECTIVE: To investigate the effects of 4-week moderate aerobic exercise plus diet control on serum levels of total insulin-like growth factor 1(IGF-1) and IGF-1 binding protein-3 (IGFBP-3) as well as IGF-1 activity (reflected by molar ratio of IGF-1/IGFBP-3) in female obese adolescents and youths, and their possible role on fat loss, and improvement of glucose and lipid metabolism. METHODS: Nine female obese youths (age:18~19 y) and 30 female obese adolescents (age:14~16 y) were recruited and undertook 4-week aerobic exercise such as swimming and jogging (6 days/week, twice a day, 2 h/time with 5 min rest per 30 min exercise) with gradual increase of intensity from low (heart rate immediately post-exercise of 1st week:100~120 beats/min) to moderate (heart rate immediately post-exercise of 2nd -4th weeks:120~140 beats/min) level, combined with a diet intervention (total daily energy intake of 1 400 or 1 600 kcal according to basal metabolism rate) in Shanghai Dianfeng weight loss enclosed camp...
January 8, 2018: Chinese Journal of Applied Physiology
Jose C Leyva-Corona, Javier R Reyna-Granados, Ricardo Zamorano-Algandar, Miguel A Sanchez-Castro, Milton G Thomas, R Mark Enns, Scott E Speidel, Juan F Medrano, Gonzalo Rincon, Pablo Luna-Nevarez
Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the PRL and GH/IGF-1 pathways with fertility traits such as services per conception (SPC) and days open (DO) in Holstein cattle lactating under a hot-humid climate. Ambient temperature and relative humidity were used to calculate the temperature-humidity index (THI) which revealed that the cows were exposed to heat stress conditions from June to November of 2012 in southern Sonora, Mexico...
June 20, 2018: Tropical Animal Health and Production
Christina M Lovato, Patricia L Kapsner
A 22-year-old woman presented with worsening vision loss and headaches. A diagnosis of acromegaly was confirmed after detection of an invasive pituitary macroadenoma and biochemical testing. Despite two attempts of surgical debulking of the tumour and administration of long-acting octreotide and cabergoline, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were uncontrolled. The patient experienced persistent headaches despite surgery, gamma knife radiation and ventriculoperitoneal shunt placement; she was then enrolled in the ACCESS trial (ClinicalTrials...
June 19, 2018: BMJ Case Reports
Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo, Carla Giordano
OBJECTIVE: To evaluate the impact of gender on the clinical and metabolic parameters in prepubertal GHD children at diagnosis and during GH treatment (GHT). DESIGN: The data of 105 prepubertal children (61 males, 44 females, mean age 6.8 ± 0.7 years) affected by idiopathic GHD were retrospectively evaluated. METHODS: Body height, BMI, waist circumference (WC), IGF-I, HbA1c, lipid profile, fasting and after-OGTT glucose and insulin levels, insulin sensitivity and secretion indices were evaluated at baseline and after 24 months of GHT...
June 20, 2018: Endocrine Connections
Z Zhang, L Li, Z K Li, F Wu, B Y Hang, B Y Cai, Z F Weng, L Zhao, C F Ding, Y G Du
Objective: To observe the effects of mulberry leaf polysaccharide (MLP) on insulin-like growth factor 1 (IGF-1) and insulin-like growth factor blinding protein 3 (IGFBP-3) as well as the expression of IGF-1 and IGFBP-3 mRNA in the kidney of type 1 Diabetic Nephropathy (DN) rats, and to investigate its therapeutic effects and underlying mechanisms. Methods: Type 1 DN rat model was established by intraperitoneally injecting streptozocin (STZ). SD rats were randomly divided into the control, model, insulin and MLP groups, with eight rats in each group...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Edward J Goetzl, Carlos Nogueras-Ortiz, Maja Mustapic, Roger J Mullins, Erin L Abner, Janice B Schwartz, Dimitrios Kapogiannis
Exosomes derived from chondroitin sulfate proteoglycan (CSPG) 4 type neural precursor cells (CSPG4Es) were purified from human plasma by sequential immunoabsorption with anti-CSPG4 and anti-platelet growth factor receptor α mAb to characterize the potential in vivo roles of CSPG4 cells in neuronal repair. Hepatocyte growth factor, fibroblast growth factors (FGFs)-2 and -13, and type 1 insulin-like growth factor (IGF-1), which enhance neuronal survival and functions, were quantified in CSPG4E extracts. For CSPG4Es of 24 healthy control subjects, mean levels of hepatocyte growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly higher by up to 7-fold than in their neuronal-derived exosomes, and mean levels of all 4 growth factors were significantly higher by up to 8-fold than in their astrocyte-derived exosomes...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Clara I Juárez-Vázquez, Carmen M Gurrola-Díaz, Belinda Vargas-Guerrero, José A Domínguez-Rosales, Jessica F Rodriguez-Ortiz, Patricio Barros-Núñez, Silvia E Flores-Martínez, José Sánchez-Corona, Mónica A Rosales-Reynoso
Objectives: The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues. This study aimed to evaluate the Igf-1r , Insr , and Igf-1 gene expression in colon and liver of streptozotocin-induced diabetic rats in response to insulin glargine, neutral protamine Hagedorn (NPH) insulin, and metformin treatments. Materials and Methods: Male Wistar rats were induced during one week with streptozotocin to develop Type 2 Diabetes (T2D) and then randomly distributed into four groups...
May 2018: Iranian Journal of Basic Medical Sciences
Muna Alemi Yahya, Shilhav Meisel Sharon, Shay Hantisteanu, Mordechai Hallak, Ilan Bruchim
Treatment of patients with gynecologic malignancies diagnosed at advanced stages remains a therapeutic challenge. Survival rates of these patients remain significantly low, despite surgery and chemotherapy. Advances in understanding the role of the immune system in the pathogenesis of cancer have led to the rapid evolution of immunotherapeutic approaches. Immunotherapeutic strategies, including targeting specific immune checkpoints, as well as dendritic cell (DC) immunotherapy are being investigated in several malignancies, including gynecological cancers...
2018: Frontiers in Endocrinology
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