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https://www.readbyqxmd.com/read/29052864/short-term-hypoxia-upregulated-mas-receptor-expression-to-repress-the-at1-r-signaling-pathway-and-attenuate-ang-ii-induced-cardiomyocyte-apoptosis
#1
Ruey-Lin Chang, Chih-Fen Chang, Da-Tong Ju, Tsung-Jung Ho, Tung-Ti Chang, Jing-Wei Lin, Jia-Chun Le, Shiu-Min Cheng, Cecilia-Hsuan Day, V Vijaya Padma, Chih-Yang Huang
Hypertension-stimulated cardiac hypertrophy and apoptosis play critical roles in the progression of heart failure. Our previous study suggested that hypertensive angiotensin II (Ang II) enhanced insulin-like growth factor receptor II (IGF-IIR) expression and cardiomyocyte apoptosis, which are involved JNK activation, sirtuin1 (SIRT1) degradation, and heat-shock transcription factor 1 (HSF1) acetylation. Moreover, previous studies have implied that short-term hypoxia (STH) might exert cardioprotective effects...
October 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29052839/effects-of-microrna-206-and-its-target-gene-igf-1-on-sevoflurane-induced-activation-of-hippocampal-astrocytes-in-aged-rats-through-the-pi3k-akt-creb-signaling-pathway
#2
Tie-Jun Liu, Bin Wang, Qun-Xi Li, Xiao-Liu Dong, Xiao-Liang Han, Shu-Bo Zhang
The study aims to explore the effects of microRNA-206 (miR-206) targeting IGF-1 on the activation of hippocampal astrocytes in aged rats induced by sevoflurane through the PI3K/AKT/CREB signaling pathway. Wistar rats and astrocytes were divided into the normal/blank, sham/negative control (NC), sevoflurane (sevo), miR-206 mimics + sevo, miR-206 inhibitors + sevo, miR-206 NC + sevo, IGF-1 shRNA + sevo and miR-206 inhibitors + IGF-1 shRNA + sevo groups. The Morris water maze test was exhibited to assess the cognitive functions...
October 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29051069/procyanidins-from-cinnamomi-cortex-promote-proteasome-independent-degradation-of-nuclear-nrf2-through-phosphorylation-of-insulin-like-growth-factor-1-receptor-in-a549%C3%A2-cells
#3
Tomokazu Ohnuma, Kazuya Sakamoto, Asumi Shinoda, Chiaki Takagi, Shoko Ohno, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka
Many lines of evidence demonstrate that transcription factor nuclear factor-E2-related factor 2 (Nrf2) plays essential roles in cancer cell proliferation and resistance to chemotherapy, thereby indicating that suppression of abnormal Nrf2 activation is needed for a new therapeutic approach. Our previous studies reported that procyanidins prepared from Cinnamomi Cortex extract (CCE) have an ability to suppress cytoprotective enzymes and cell proliferation in human cancer cells with activated Nrf2. In the present study, we investigated the mechanism of CCE procyanidin-mediated antagonization of Nrf2...
October 16, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29045833/intestinal-fork-head-regulates-nutrient-absorption-and-promotes-longevity
#4
Ekin Bolukbasi, Mobina Khericha, Jennifer C Regan, Dobril K Ivanov, Jennifer Adcott, Miranda C Dyson, Tobias Nespital, Janet M Thornton, Nazif Alic, Linda Partridge
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription factor homolog Fork Head (FKH). Intestinal FKH induction extends lifespan, highlighting a role for the gut. FKH binds to and is phosphorylated by AKT and Target of Rapamycin. Gut-specific FKH upregulation improves gut barrier function in aged flies...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29044624/effect-of-chronic-alcohol-abuse-on-anabolic-and-catabolic-signaling-pathways-in-human-skeletal-muscle
#5
Boris S Shenkman, Svetlana P Belova, Olga E Zinovyeva, Nudlya D Samkhaeva, Timur M Mirzoev, Natalia A Vilchinskaya, Erzhena G Altaeva, Olga V Turtikova, Tatiana Y Kostrominova, Tatiana L Nemirovskaya
BACKGROUND: Animal studies showed that alcoholic myopathy is characterized by the reduction of myofiber cross sectional area (CSA) and by impaired anabolic signaling. The goal of the current study was to compare changes in CSA and fiber type composition with modifications in anabolic and catabolic signaling pathways at the early stages of alcohol misuse in humans. METHODS: Skeletal muscle samples from seven male patients with chronic alcohol abuse (AL; 47.7±2.0 years old; alcohol misuse duration 7...
October 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29044208/growth-factors-regulate-phospholipid-biosynthesis-in-human-fibroblast-like-synoviocytes-obtained-from-osteoarthritic-knees
#6
Katarzyna D Sluzalska, Gerhard Liebisch, Jochen Wilhelm, Bernd Ishaque, Holger Hackstein, Gerd Schmitz, Markus Rickert, Juergen Steinmeyer
Elevated levels of growth factors and phospholipids (PLs) have been found in osteoarthritic synovial fluid (SF), although the metabolic regulation of PLs is currently unknown. This study aimed to determine the effects of growth factors on the biosynthesis of PLs by fibroblast-like synoviocytes (FLS) obtained from human osteoarthritic knee joints. Electrospray ionization tandem mass spectrometry was applied to analyse the newly synthesized PLs. In the presence of stable isotope-labelled PL precursors, cultured FLS were treated with either transforming growth factor-β1 (TGF-β1), bone morphogenetic protein (BMP)-2, BMP-4, BMP-7 or insulin-like growth factor-1 (IGF-1) alone or in combination with specific inhibitors of cell signalling pathways...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042933/effects-of-exogenous-growth-hormone-administration-on-dexamethasone-induced-growth-impairment-in-adolescent-male-rats
#7
Myung-Gyou Kim, Jeong-Seok Oh, Hye Kyung Kim, Kang-Hyun Leem
Growth impairment (GI) is one of the adverse effects of dexamethasone (DXM), and growth hormone (GH) has been used clinically to improve GI. The present study aimed to evaluate the manner in which DXM disturbs the growth rate of longitudinal bones, and the recovery effects of GH on DXM-induced GI in the longitudinal bones of adolescent male rats. In the first experiment, DXM (0, 0.5, 1, 2 and 5 mg/kg) was administered subcutaneously to identify a potential dose-dependent activity and calculate the median effective dose (ED50) of DXM-induced GI...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042931/delivery-of-biotinylated-igf-1-with-biotinylated-self-assembling-peptides-combined-with-bone-marrow-stem-cell-transplantation-promotes-cell-therapy-for-myocardial-infarction
#8
Ming Zhang, Wen-Wei Ai, Zhi-Liang Mei, Yun-Hua Hu, Zhi-Ling Zhang
Cell therapy is a promising approach for cardiac repair. The aim of the present study was to determine the feasibility of using biotinylated insulin-like growth factor 1 (IGF-1) with biotinylated self-assembling peptides (tethered IGF-1) combined with bone marrow stem cells (BMSCs) transplantation for the treatment of heart failure. Tethered IGF-1 was synthesized and its effect on H9c2 cells was analyzed. Reverse transcription-quantitative polymerase chain reaction and western blot assays demonstrated that tethered IGF-1 did not significantly affect the expression and phosphorylation of AKT, whereas it significantly increased the expression of cardiac troponin T (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040592/the-association-between-igf-i-and-igfbp-3-and-incident-diabetes-in-an-older-population-of-men-and-women-in-the-cardiovascular-health-study
#9
Chino S Aneke-Nash, Xiaonan Xue, Qibin Qi, Mary L Biggs, Anne Cappola, Lewis Kuller, Michael Pollak, Bruce M Psaty, David Siscovick, Kenneth Mukamal, Howard D Strickler, Robert C Kaplan
Context: Insulin like growth factor-I (IGF-I) has structural/functional similarities with insulin and may play a role in glucose homeostasis, along with IGF binding protein-3 (IGFBP-3), which binds the majority of circulating IGF-I. Objective: To assess whether IGF-I and IGFBP-3 are associated with higher risk of incident diabetes in older adults. Design: Participants in the Cardiovascular Health Study (n=3133), a cohort of adults aged ≥65 years, were observed for 16 years (n=3133) for the development of incident diabetes...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29040223/effect-of-losartan-on-the-acute-response-of-human-elderly-skeletal-muscle-to-exercise
#10
Mette Flindt Heisterberg, Jesper L Andersen, Peter Schjerling, Jacob Bülow, Jeppe Bo Lauersen, Heidi L Roeber, Michael Kjaer, Abigail L Mackey
PURPOSE: To investigate the effect of blocking the angiotensin II type I receptor (AT1R) upon the response to acute heavy resistance exercise in elderly human skeletal muscle. The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by downregulation of TGF-β and upregulation of IGF-1 signalling. METHODS: 28 healthy elderly men (+64 years) were randomized into two groups, consuming either AT1R blocker (Losartan, 100mg/day) or Placebo for 18 days prior to exercise...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29039467/insulin-like-growth-factor-binding-protein-6-released-from-human-mesenchymal-stem-cells-confers-neuronal-protection-through-igf-1r-mediated-signaling
#11
Hyo-Jin Jeon, Jihye Park, Joo-Hyun Shin, Mi-Sook Chang
Human bone marrow‑derived mesenchymal stem cells (hMSCs) are a desirable cell source for cell‑based therapy to treat nervous system injuries due to their ability to differentiate into specific cell types. In addition to their multipotency, hMSCs render the tissue microenvironment more favorable for tissue repair by secreting various growth factors. Our previous study demonstrated that hMSCs secrete several growth factors, including several insulin‑like growth factor binding proteins (IGFBPs). Among these, IGFBP‑6 binds with high affinity and inhibits insulin growth factor‑2 (IGF‑2) to inhibit the growth of IGF‑2‑dependent tumors...
October 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038353/cell-cycle-dependent-expression-of-the-cck2-receptor-by-gastrointestinal-myofibroblasts-putative-role-in-determining-cell-migration
#12
Akos Varga, Jothi Dinesh Kumar, Alec W M Simpson, Steven Dodd, Peter Hegyi, Graham J Dockray, Andrea Varro
The well-known action of the gastric hormone gastrin in stimulating gastric acid secretion is mediated by activation of cholecystokinin-2 receptors (CCK2R). The latter are expressed by a variety of cell types suggesting that gastrin is implicated in multiple functions. During wound healing in the stomach CCK2R may be expressed by myofibroblasts. We have now characterized CCK2R expression in cultured myofibroblasts. Immunocytochemistry showed that a relatively small proportion (1-6%) of myofibroblasts expressed the receptor regardless of the region of the gut from which they were derived, or whether from cancer or control tissue...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29038330/can-growth-hormone-treatment-improve-growth-in-children-with-severe-growth-failure-due-to-anorexia-nervosa-a-preliminary-pilot-study
#13
Juliane Leger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Catherine Doyen, Emmanuel Ecosse, Jean-Claude Carel, Marie-France Le Heuzey
BACKGROUND/AIMS: Growth failure is a difficult, but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN. METHODS: We carried out a retrospective observational study. Ten girls diagnosed with AN at 10.0±1.9 years, with prolonged severe growth failure (HV <2.5 cm/year for at least 18 months) at the age of 13...
October 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29037858/co-localization-of-igfbp-1-protein-kinase-csnk-2%C3%AE-and-mtor-in-hepg2-cells-as-demonstrated-by-dual-immunofluorescence-and-in-situ-proximity-ligation-assay
#14
Sahil S Singal, Karen Nygard, Manthan R Dhruv, Kyle Biggar, Majida Abu Shehab, Shawn Shun-Cheng Li, Thomas Jansson, Madhulika B Gupta
Insulin-like growth factor binding protein (IGFBP)-1 influences fetal growth by modifying IGF-I bioavailability. IGFBP-1 phosphorylation, which markedly increases its affinity for IGF-I, is regulated by mTOR and CSNK-2. However, the underlying molecular mechanisms remain unknown. We examined the cellular localization and potential interactions of IGFBP-1, CSNK-2β, and mTOR as a prerequisite for protein-protein interaction. Confocal/Z-stack analysis of dual immunofluorescence images indicated a potential perinuclear co-localization between IGFBP-1+CSNK-2β whereas a nuclear co-localization between CSNK-2β+mTOR...
October 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29037141/analysis-of-four-circulating-complexes-of-insulin-like-growth-factor-binding-proteins-in-human-blood-during-aging
#15
O Nedić, M Šunderić, N Gligorijević, V Malenković, G Miljuš
The primary role of insulin-like growth factor binding proteins (IGFBPs) is to regulate availability of IGFs for interacting with receptors, but IGFBPs perform IGF-independent actions as well. The availability and activity of IGFBPs in the circulation is influenced primarily by their concentration and structural modifications, but possibly also by interaction with major plasma proteins such as transferrin, alpha-2-macroglobulin (α2M), and fibrinogen. Four types of circulating IGFBP complexes were examined in this study by immuno- and ligand-binding assays in adults of different age...
October 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29036907/a-functional-interplay-between-igf-1-and-adiponectin
#16
REVIEW
Stefania Orrù, Ersilia Nigro, Annalisa Mandola, Andreina Alfieri, Pasqualina Buono, Aurora Daniele, Annamaria Mancini, Esther Imperlini
A functional relationship is suggested between two well-known protein hormones, insulin-like growth factor 1 (IGF-1) and adiponectin. In the last two decades in fact, different experimental evidence has indicated a non-random link between them. Here, we describe briefly the IGF-1 and adiponectin systems, and we then focus on their putative interplay in relation to several pathological conditions, including obesity, diabetes, insulin resistance, cardiovascular disease, and cancer. Although the existing studies are hardly comparable, they definitely indicate a functional connection between these two protein hormones...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29031906/suckling-induced-insulin-like-growth-factor-1-igf-1-release-in-mother-rats
#17
András H Lékó, Melinda Cservenák, Árpád Dobolyi
OBJECTIVE: Lactation involves significant neuroendocrine changes. The elevated prolactin (PRL) release from the pituitary, induced markedly by suckling, is the most relevant example. Suckling also causes a significant and rapid elevation in growth hormone (GH) levels. GH is necessary for milk synthesis as milk yield is stopped completely in the absence of PRL and GH, while the absence of PRL alone causes only a 50% reduction. Insulin-like growth factor-1 (IGF-1) plays an important role in the GH axis...
October 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29031714/dwarfism-and-insulin-resistance-in-male-offspring-caused-by-%C3%AE-1-adrenergic-antagonism-during-pregnancy
#18
Rebecca Oelkrug, Beate Herrmann, Cathleen Geissler, Lisbeth Harder, Christiane Koch, Hendrik Lehnert, Henrik Oster, Henriette Kirchner, Jens Mittag
OBJECTIVE: Maternal and environmental factors control the epigenetic fetal programming of the embryo, thereby defining the susceptibility for metabolic or endocrine disorders in the offspring. Pharmacological interventions required as a consequence of gestational problems, e.g. hypertension, can potentially interfere with correct fetal programming. As epigenetic alterations are usually only revealed later in life and not detected in studies focusing on early perinatal outcomes, little is known about the long-term epigenetic effects of gestational drug treatments...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29031555/beneficial-effects-of-dietary-restriction-in-aging-brain
#19
REVIEW
Ibanylla Kynjai Hynniewta Hadem, Teikur Majaw, Babiangshisha Kharbuli, Ramesh Sharma
Aging is a multifactorial complex process that leads to the deterioration of biological functions wherein its underlying mechanism is not fully elucidated. It affects the organism at the molecular and cellular level that contributes to the deterioration of structural integrity of the organs. The central nervous system is the most vulnerable organ affected by aging and its effect is highly heterogeneous. Aging causes alteration in the structure, metabolism and physiology of the brain leading to impaired cognitive and motor-neural functions...
October 12, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29031192/growth-and-endocrine-function-in-children-with-dravet-syndrome
#20
Krista Eschbach, Sharon Scarbro, Elizabeth Juarez-Colunga, Victoria Allen, Stephanie Hsu, Kelly Knupp
PURPOSE: Dravet syndrome is an intractable childhood epilepsy syndrome most often associated with an SCN1A mutation. In our clinical practice, several patients with Dravet syndrome were noted to have short stature and endocrine dysfunction. This has not been reported in the literature. Our study aim was to describe growth measurements and endocrine abnormalities in children with Dravet syndrome. METHOD: A retrospective chart review was performed at a single institution...
September 29, 2017: Seizure: the Journal of the British Epilepsy Association
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