Shirin Yaghoobpoor, Mobina Fathi, Kimia Vakili, Fatemeh Sayehmiri, Milad Alipour, Zahra Sadat Miriran, Hani Ghayyem, Zohreh Tutunchian, Ramtin Hajibeygi, Zehra Batool, Moein Mirzadeh, Mohammad Hossein Aghazadeh, Mohammadreza Hajiesmaeili
BACKGROUND AND OBJECTIVE: Multiple sclerosis (MS) is a chronic progressive autoimmune disorder of the central nervous system (CNS) that can cause inflammation, demyelination, and axon degeneration. Insulin-like growth factor-1 (IGF-1) is a single-chain polypeptide mainly synthesized in the liver and brain. IGF-1 causes neuronal and non-neuronal cell proliferation, survival, and differentiation. Therefore, it can be used in treating neuro-demyelinating diseases such as MS. The current systematic review and meta-analysis aims to compare the levels of IGF-1 in MS patients and healthy controls and also investigates IGF binding proteins (IGF-BP) and growth hormone (GH) levels between MS patients and healthy controls...
2024: PloS One