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Lenticule implantation

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https://www.readbyqxmd.com/read/29408829/femtosecond-laser-assisted-small-incision-endokeratophakia-using-a-xenogeneic-lenticule-in-rhesus-monkeys
#1
Miao He, He Jin, Hong He, Hui Ding, Wei Wang, Liangping Liu, Chi Zhang, Xingwu Zhong
PURPOSE: To evaluate the feasibility and safety of xenogeneic endokeratophakia in rhesus monkeys and to explore the effects of a concave lenticule on refractive power. METHODS: Three adult New Zealand white rabbits and 6 healthy rhesus monkeys were used. The xenogenic concave grafts were created from the rabbits using a modified small incision lenticule extraction technique; after being cryopreserved in glycerol for 1 week, the grafts were implanted into the monkey recipient corneas...
March 2018: Cornea
https://www.readbyqxmd.com/read/29382905/biological-corneal-inlay-for-presbyopia-derived-from-small-incision-lenticule-extraction-smile
#2
Yu-Chi Liu, Ericia Pei Wen Teo, Heng Pei Ang, Xin Yi Seah, Nyein Chan Lwin, Gary Hin Fai Yam, Jodhbir S Mehta
Corneal inlays are a relatively new treatment option for presbyopia. Using biological inlays, derived from lenticules extracted from small incision lenticule extraction, may offer advantages over commercialized synthetic inlays in the aspect of biocompatibility. We conducted a non-human primate study to evaluate the safety, predictability, efficacy and tissue response after autogeneic, decellularized xenogeneic and xenogeneic lenticule implantation. The lenticule implantation effectively resulted in central corneal steepening (simulated keratometric values increased by 1...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315440/femtosecond-laser-assisted-stromal-lenticule-addition-keratoplasty-for-the-treatment-of-advanced-keratoconus-a-preliminary-study
#3
Leonardo Mastropasqua, Mario Nubile, Niccolò Salgari, Rodolfo Mastropasqua
PURPOSE: To investigate the in vivo effect of a novel femtosecond laser-assisted procedure termed stromal lenticule addition keratoplasty for advanced keratoconus. METHODS: Ten patients with stage III and IV stable keratoconus were included. Negative meniscus-shaped stromal lenticules were produced from corneoscleral eye bank buttons with a refractive lenticule extraction procedure with a 500-kHz VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Recipient corneas underwent a modified femtosecond laser flap-cut procedure to produce an intrastromal pocket and lenticules were implanted...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29303885/candida-endophthalmitis-after-descemet-stripping-automated-endothelial-keratoplasty-with-grafts-from-both-eyes-of-a-donor-with-possible-systemic-candidiasis
#4
Sotiria Palioura, Kavitha Sivaraman, Madhura Joag, Adam Sise, Juan F Batlle, Darlene Miller, Edgar M Espana, Guillermo Amescua, Sonia H Yoo, Anat Galor, Carol L Karp
PURPOSE: To report 2 cases with late postoperative Candida albicans interface keratitis and endophthalmitis after Descemet stripping automated endothelial keratoplasty (DSAEK) with corneal grafts originating from a single donor with a history of presumed pulmonary candidiasis. METHODS: Two patients underwent uncomplicated DSAEK by 2 corneal surgeons at different surgery centers but with tissue from the same donor and were referred to the Bascom Palmer Eye Institute with multifocal infiltrates at the graft-host cornea interface 6 to 8 weeks later, and anterior chamber cultures that were positive for the same genetic strain of C...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29259313/tuck-in-lamellar-keratoplasty-with-an-lenticule-obtained-by-small-incision-lenticule-extraction-for-treatment-of-post-lasik-ectasia
#5
Yang Jiang, Ying Li, Shan Yang, Thomas Chengxuan Lu
Corneal ectasia is a rare but serious post-operative complication of LASIK. Our main aim was to describe and evaluate the efficacy and safety of tuck-in lamellar keratoplasty with an lenticule obtained by SMILE for treatment of Post LASIK Ectasia. Tuck-in lamellar keratoplasty was performed on three post-LASIK cornea ectasia patients (three eyes) with central corneal thickness less than 400 µm. Each patient was monitored for at least 12 months. Our primary outcomes measured pre and post-operatively included: Anterior segment optical coherence tomography(AS-OCT), corneal topography and monitored by slit-lamp microscopy...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227511/predictive-formula-for-refraction-of-autologous-lenticule-implantation-for-hyperopia-correction
#6
Meng Li, Meiyan Li, Ling Sun, Katherine Ni, Xingtao Zhou
PURPOSE: To create a formula to predict refractive correction of autologous lenticule implantation for correction of hyperopia (with myopia in one eye and hyperopia in the contralateral eye). METHODS: In this prospective study, 10 consecutive patients (20 eyes) who had myopia in one eye and hyperopia in the contralateral eye were included. The preoperative spherical equivalent was -3.31 ± 1.73 diopters (D) for the myopic eyes and +4.46 ± 1.97 D for the hyperopic eyes...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28965357/in-vivo-confocal-microscopic-investigation-of-the-cornea-after-autologous-implantation-of-lenticules-obtained-through-small-incision-lenticule-extraction-for-treatment-of-hyperopia
#7
Meiyan Li, Meng Li, Ling Sun, Tian Han, Lan Ding, Jun Xiang, Xingtao Zhou
PURPOSE: To investigate re-innervation in the implanted lenticule, as well as changes to the cornea, after correcting hyperopia with an autologous implantation of a lenticule obtained through small incision lenticule extraction (SMILE). METHODS: This study retrospectively analysed re-innervation in the implanted lenticule, as well as microscopic morphological changes in the corneal architecture of the recipient cornea in five patients (with myopia in one eye and hyperopia in the contralateral eye) who received SMILE in the myopic eye and femtosecond laser in situ keratomileusis (FS-LASIK) combined with lenticule implantation in the contralateral hyperopic eye...
January 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28880334/a-multicenter-retrospective-survey-of-refractive-surgery-in-78-248-eyes
#8
Kazutaka Kamiya, Akihito Igarashi, Ken Hayashi, Kazuno Negishi, Masaki Sato, Hiroko Bissen-Miyajima
PURPOSE: To retrospectively evaluate the current practice, trends, and outcomes of refractive surgery in Japan. METHODS: This multicenter survey comprised 78,248 eyes of 39,727 consecutive patients who underwent refractive surgery at 45 major institutions in Japan. The corresponding ophthalmologists responded to a selfadministered questionnaire. The authors especially evaluated the safety, efficacy, predictability, stability, and adverse events of LASIK and phakic intraocular lens (IOL) implantation 3 months postoperatively...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28777101/new-graft-insertion-device-for-descemet-stripping-automated-endothelial-keratoplasty
#9
Takeshi Soma, Shizuka Koh, Naoyuki Maeda, Kikuo Mitomo, Andrew J Quantock, Kohji Nishida
PURPOSE: Corneal endothelial dysfunction is a major indication for corneal graft surgery worldwide, and although surgical intervention through a range of posterior lamellar surgeries has proven to be hugely beneficial, challenges remain. This is especially so where the anterior chamber is relatively shallow, as is often the case in the Asian population, though not exclusively so. In this study, we introduce a new insertion device to deliver endothelial graft tissue for Descemet stripping automated endothelial keratoplasty (DSAEK)...
August 2, 2017: Cornea
https://www.readbyqxmd.com/read/28407161/preliminary-evidence-of-successful-near-vision-enhancement-with-a-new-technique-presbyopic-allogenic-refractive-lenticule-pearl-corneal-inlay-using-a-smile-lenticule
#10
Soosan Jacob, Dhivya Ashok Kumar, Amar Agarwal, Athiya Agarwal, Ramalingam Aravind, A I Saijimol
PURPOSE: To describe a new technique (PrEsbyopic Allogenic Refractive Lenticule [PEARL] inlay) using an allogenic corneal inlay prepared from a small incision lenticule extraction (SMILE) lenticule. METHODS: A SMILE lenticule of specified thickness (mean: 61.5 ± 3.32 µm) was trephined at the center to 1-mm diameter and implanted in the cornea on the coaxially sighted light reflex under a femtosecond laser-created cap of 120 µm in the nondominant eye of presbyopic patients...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28399038/intraoperative-optical-coherence-tomography-assisted-descemet-stripping-automated-endothelial-keratoplasty-for-anterior-chamber-fibrous-ingrowth
#11
Tarek A Shazly, Lillian K To, Ian P Conner, Ladan Espandar
PURPOSE: Here, we present the first reported case of intraoperative optical coherence tomography (OCT)-assisted Descemet membrane stripping automated endothelial keratoplasty (DSAEK) in a patient with anterior segment fibrous ingrowth. METHODS: A 61-year-old woman with corneal edema and chronic angle-closure glaucoma secondary to fibrous ingrowth after 2 glaucoma shunt device implantations underwent dissection and removal of anterior chamber fibrous ingrowth and DSAEK...
June 2017: Cornea
https://www.readbyqxmd.com/read/28060071/corneal-lenticule-allotransplantation-after-femtosecond-laser-small-incision-lenticule-extraction-in-rabbits
#12
Jing Zhao, Yang Shen, Mi Tian, Ling Sun, Yu Zhao, Xiaoyu Zhang, Xingtao Zhou
PURPOSE: To investigate the feasibility of allotransplanting extracted lenticules after femtosecond laser-assisted small incision lenticule extraction (SMILE) in rabbits and the subsequent healing process. METHODS: Fourteen New Zealand white rabbits were divided evenly into 2 groups. The rabbits in group A received SMILE procedures with a -6.00 D correction. The lenticules from group A were immediately inserted into a femtosecond laser-created corneal stromal pocket in group B...
February 2017: Cornea
https://www.readbyqxmd.com/read/28034710/a-multicenter-prospective-cohort-study-on-refractive-surgery-in-15-011-eyes
#13
RANDOMIZED CONTROLLED TRIAL
Kazutaka Kamiya, Akihito Igarashi, Ken Hayashi, Kazuno Negishi, Masaki Sato, Hiroko Bissen-Miyajima
PURPOSE: To assess the clinical outcomes of currently used refractive surgery procedures performed in 2015. DESIGN: Prospective, multicenter cohort study. METHODS: This prospective study included 15 011 eyes of 7622 consecutive patients who underwent laser in situ keratomileusis (LASIK), surface ablation, refractive lenticule extraction (ReLEx), or phakic intraocular lens (IOL) implantation at 42 major institutions. We determined the safety, efficacy, predictability, stability, and adverse events of these surgeries preoperatively and at 1 week and 1 and 3 months postoperatively...
March 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27975341/refractive-lenticule-implantation-for-correction-of-ametropia-case-reports-and-literature-review
#14
REVIEW
A Lazaridis, A Messerschmidt-Roth, W Sekundo, S Schulze
The ReLEx® technique allows correction of refractive errors through the creation and extraction of refractive stromal lenticules. Contrary to excimer laser corneal refractive procedures, where the stromal tissue is photoablated, the extracted lenticules obtained with ReLEx® can be preserved. Recent studies and case reports have described autologous re-implantation and allogeneic implantation of refractive lenticules into femtosecond-laser created stromal pockets in order to reverse the refractive outcome of a myopic corneal refractive procedure, correct hyperopia, aphakia, presbyopia and treat keratoconus...
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27824384/refractive-lenticule-transplantation-for-correction-of-iatrogenic-hyperopia-and-high-astigmatism-after-lasik
#15
Apostolos Lazaridis, Dan Z Reinstein, Timothy J Archer, Stephan Schulze, Walter Sekundo
PURPOSE: To design a technique for intrastromal transplantation of stromal lenticules with specific refractive power for correction of post-LASIK induced hyperopia and astigmatism. METHODS: A 28-year-old patient was referred for consultation after complicated LASIK for moderate myopia and astigmatism. The refractive error of the right eye was severely overcorrected due to data entry error. Post-LASIK refraction showed high astigmatism (right eye: +6.50 -9.00 @ 84°) and corrected distance visual acuity (CDVA) of 20/32...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27628587/corneal-thickening-and-central-flattening-induced-by-femtosecond-laser-hyperopic-shaped-intrastromal-lenticule-implantation
#16
Leonardo Mastropasqua, Mario Nubile
PURPOSE: To investigate the feasibility of the procedure and the modifications of the corneal curvature and profile obtained with a novel technique of stromal-lentoid implantation in ex vivo human corneas. DESIGN: Experimental ex vivo study in human corneas. MATERIALS AND METHODS: Twelve stromal lentoids were produced by means of hyperopic femtosecond lenticule extraction (FLEx) with the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a refractive power of +8...
August 2017: International Ophthalmology
https://www.readbyqxmd.com/read/27505318/reversible-femtosecond-laser-assisted-endokeratophakia-using-cryopreserved-allogeneic-corneal-lenticule
#17
Yuan Sun, Ting Zhang, Yuehua Zhou, Manli Liu, Yugui Zhou, Xiaonan Yang, Shengbei Weng, Chi-Ho To, Quan Liu
PURPOSE: To evaluate outcomes, reversibility, and wound healing response after the femtosecond laser-assisted endokeratophakia procedure in a rabbit model. METHODS: Allogeneic rabbit corneal lenticules were cryopreserved in liquid nitrogen for 3 months. Twenty rabbits underwent the monocular endokeratophakia procedure and were divided into four groups according to the follow-up periods. The first three groups were killed at 3 days, 2 weeks, and 6 months after endokeratophakia, respectively...
August 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27210519/decellularization-of-human-stromal-refractive-lenticules-for-corneal-tissue-engineering
#18
Gary Hin-Fai Yam, Nur Zahirah Binte M Yusoff, Tze-Wei Goh, Melina Setiawan, Xiao-Wen Lee, Yu-Chi Liu, Jodhbir S Mehta
Small incision lenticule extraction (SMILE) becomes a procedure to correct myopia. The extracted lenticule can be used for other clinical scenarios. To prepare for allogeneic implantation, lenticule decellularization with preserved optical property, stromal architecture and chemistry would be necessary. We evaluated different methods to decellularize thin human corneal stromal lenticules created by femtosecond laser. Treatment with 0.1% sodium dodecylsulfate (SDS) followed by extensive washes was the most efficient protocol to remove cellular and nuclear materials...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27143847/advances-in-femtosecond-laser-technology
#19
REVIEW
Thais Pinheiro Callou, Renato Garcia, Adriana Mukai, Natalia T Giacomin, Rodrigo Guimarães de Souza, Samir J Bechara
Femtosecond laser technology has become widely adopted by ophthalmic surgeons. The purpose of this study is to discuss applications and advantages of femtosecond lasers over traditional manual techniques, and related unique complications in cataract surgery and corneal refractive surgical procedures, including: LASIK flap creation, intracorneal ring segment implantation, presbyopic treatments, keratoplasty, astigmatic keratotomy, and intrastromal lenticule procedures.
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26603410/unilateral-corneal-ectasia-following-small-incision-lenticule-extraction
#20
Gitansha Sachdev, Mahipal S Sachdev, Ritika Sachdev, Hemlata Gupta
UNLABELLED: We describe a case of unilateral corneal ectasia in a 26-year-old man following small-incision lenticule extraction. The preoperative corneal topography was normal, with a minimum corneal thickness of 511 μm and 513 μm in the right eye and left eye, respectively. Lenticules of 85 μm and 82 μm were fashioned to offer a refractive correction of -3.75 -1.50 × 180 and -3.50 -1.50 × 165 in the right eye and left eye, respectively. Twelve months after small-incision lenticule extraction, the patient presented with early signs of ectasia in the left eye on corneal topography, which had worsened at the 18-month examination...
September 2015: Journal of Cataract and Refractive Surgery
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