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Lenticule implantation

Leonardo Mastropasqua, Mario Nubile
PURPOSE: To investigate the feasibility of the procedure and the modifications of the corneal curvature and profile obtained with a novel technique of stromal-lentoid implantation in ex vivo human corneas. DESIGN: Experimental ex vivo study in human corneas. MATERIALS AND METHODS: Twelve stromal lentoids were produced by means of hyperopic femtosecond lenticule extraction (FLEx) with the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a refractive power of +8...
September 15, 2016: International Ophthalmology
Yuan Sun, Ting Zhang, Yuehua Zhou, Manli Liu, Yugui Zhou, Xiaonan Yang, Shengbei Weng, Chi-Ho To, Quan Liu
PURPOSE: To evaluate outcomes, reversibility, and wound healing response after the femtosecond laser-assisted endokeratophakia procedure in a rabbit model. METHODS: Allogeneic rabbit corneal lenticules were cryopreserved in liquid nitrogen for 3 months. Twenty rabbits underwent the monocular endokeratophakia procedure and were divided into four groups according to the follow-up periods. The first three groups were killed at 3 days, 2 weeks, and 6 months after endokeratophakia, respectively...
August 1, 2016: Journal of Refractive Surgery
Gary Hin-Fai Yam, Nur Zahirah Binte M Yusoff, Tze-Wei Goh, Melina Setiawan, Xiao-Wen Lee, Yu-Chi Liu, Jodhbir S Mehta
Small incision lenticule extraction (SMILE) becomes a procedure to correct myopia. The extracted lenticule can be used for other clinical scenarios. To prepare for allogeneic implantation, lenticule decellularization with preserved optical property, stromal architecture and chemistry would be necessary. We evaluated different methods to decellularize thin human corneal stromal lenticules created by femtosecond laser. Treatment with 0.1% sodium dodecylsulfate (SDS) followed by extensive washes was the most efficient protocol to remove cellular and nuclear materials...
2016: Scientific Reports
Thais Pinheiro Callou, Renato Garcia, Adriana Mukai, Natalia T Giacomin, Rodrigo Guimarães de Souza, Samir J Bechara
Femtosecond laser technology has become widely adopted by ophthalmic surgeons. The purpose of this study is to discuss applications and advantages of femtosecond lasers over traditional manual techniques, and related unique complications in cataract surgery and corneal refractive surgical procedures, including: LASIK flap creation, intracorneal ring segment implantation, presbyopic treatments, keratoplasty, astigmatic keratotomy, and intrastromal lenticule procedures.
2016: Clinical Ophthalmology
Gitansha Sachdev, Mahipal S Sachdev, Ritika Sachdev, Hemlata Gupta
UNLABELLED: We describe a case of unilateral corneal ectasia in a 26-year-old man following small-incision lenticule extraction. The preoperative corneal topography was normal, with a minimum corneal thickness of 511 μm and 513 μm in the right eye and left eye, respectively. Lenticules of 85 μm and 82 μm were fashioned to offer a refractive correction of -3.75 -1.50 × 180 and -3.50 -1.50 × 165 in the right eye and left eye, respectively. Twelve months after small-incision lenticule extraction, the patient presented with early signs of ectasia in the left eye on corneal topography, which had worsened at the 18-month examination...
September 2015: Journal of Cataract and Refractive Surgery
Ting Zhang, Yuan Sun, Manli Liu, Yugui Zhou, Danyang Wang, Yili Chen, Quan Liu
PURPOSE: To investigate the feasibility of allogeneic corneal lenticule implantation using the femtosecond laser as a method for cornea remodeling. METHODS: Small incision lenticule extraction was performed on the right eyes of 15 New Zealand white rabbits. Corneal intrastromal pockets were created with a femtosecond laser on the left eyes. Allogeneic corneal lenticule implantation was performed on the left eye immediately after the lenticule was extracted from the right eye...
November 2015: Journal of Refractive Surgery
Siamak Delfazayebaher, Sepehr Feizi, Mohammad Ali Javadi, Alireza Baradaran-Rafii, Mohammad Mehdi Sadoughi, Amir Faramarzi
PURPOSE: To describe a sign that can confirm the correct position of donor lenticules during Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: In this clinical and laboratory study, DSAEK was performed in 3 eyes with a diagnosis of pseudophakic bullous keratopathy. Additionally, 2 whole globes and 2 precut corneoscleral buttons were procured for the purpose of the laboratory part of the study. After removal of recipient Descemet membrane, the donor graft was inserted into the anterior chamber, unfolded, and attached to the posterior corneal stroma with an air bubble...
August 2015: Cornea
Rui Liu, Jing Zhao, Ye Xu, Meiyan Li, Lingling Niu, Huiying Liu, Ling Sun, Renyuan Chu, Xingtao Zhou
PURPOSE: Lenticule implantation can be used to correct vision problems. However, it is significantly restrained by the sources of autologous lenticules. The aim of the present study was to investigate the feasibility and effects of femtosecond laser-assisted corneal small incision allogenic intrastromal lenticule implantation (AILI) in monkeys. METHODS: Six healthy adult monkeys were included in this study. Femtosecond lenticule extraction (-4.0 diopter [D] correction, 5...
June 2015: Investigative Ophthalmology & Visual Science
Ling Sun, Peijun Yao, Meiyan Li, Yang Shen, Jing Zhao, Xingtao Zhou
PURPOSE: To evaluate the safety, effectiveness, stability, and predictability of implanting autologous lenticules obtained from small incision lenticule extraction for the treatment of hyperopia. METHODS: Five patients (10 eyes) with one myopic eye and one hyperopic eye were enrolled. The myopic eye was treated with small incision lenticule extraction; a lenticule was extracted and subsequently implanted in the hyperopic eye. Follow-up was at 1 day, 1, 3, 6, and 9 months, and 1 year postoperatively...
June 2015: Journal of Refractive Surgery
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2015: Journal of Refractive Surgery
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2015: Journal of Refractive Surgery
(no author information available yet)
No abstract text is available yet for this article.
January 2015: Journal of Refractive Surgery
William R Calhoun, Esen K Akpek, Richard Weiblinger, Ilko K Ilev
PURPOSE: The aim of this study was to evaluate the clarity of gamma-irradiated sterile corneal donor lenticules. METHODS: Broadband UV, visible, and near-infrared (200-850 nm) light transmission was measured through gamma-irradiated, sterile partial-thickness, and full-thickness donor lenticules and fresh corneal tissues and compared with standard acrylic intraocular lens (IOL) implants using a conventional spectrophotometer technique. RESULTS: All tissues had high light transmission (≥ 90%) in the visible and near-infrared regions and very low (<2%) transmission below 290 nm...
February 2015: Cornea
Sri Ganesh, Sheetal Brar, Pallavi A Rao
PURPOSE: To describe the technique of cryopreservation of corneal lenticules extracted after small incision refractive lenticule extraction (ReLEx SMILE) and initial results of femtosecond laser intrastromal lenticular implantation for hyperopia. METHODS: Lenticules were collected from patients undergoing ReLEx SMILE for the correction of myopia and subjected to a tissue processing technique and cryopreservation. These lenticules were subsequently used to treat 8 hyperopic eyes and 1 aphakic eye...
December 2014: Cornea
Louis Hoffart, Gérard Carles, Frédéric Matonti
PURPOSE: Clinical assessment of AlphaCor keratoprosthesis and evaluation of surgical method to treat keratolysis in case of stromal necrosis occurrence. METHODS: This is a noncomparative, retrospective, interventional case series. The medical records of 12 eyes of 12 patients who underwent consecutive AlphaCor keratoprosthesis implantations were reviewed. Patients with severe bilateral corneal pathology unsuitable for a conventional corneal graft, a best-corrected visual acuity (BCVA) from light perception (LP) to 20/200, with no active ocular surface inflammation, controlled intraocular pressure prior to the surgery, and an unstimulated Schirmer test of >2...
January 2015: European Journal of Ophthalmology
Bryan S Lee
PURPOSE OF REVIEW: Treatment of hyperopia presents greater challenges than treatment of myopia for multiple reasons, including the fact that hyperopia tends to progress with age and becomes more symptomatic with the loss of accommodation. RECENT FINDINGS: Despite these issues, surgeons have multiple options to treat hyperopia successfully. Modern laser vision correction has high success rates for most patients and performs acceptably in the presence of high hyperopia or high cylinder...
July 2014: Current Opinion in Ophthalmology
Jeewan S Titiyal, Sana I Tinwala, Himanshu Shekhar, Rajesh Sinha
The purpose of this study was to describe a modified technique of sutureless DSAEK with continuous pressurized internal air tamponade. This was a prospective interventional case series, single-center, institutional study. Twenty-seven patients with corneal decompensation without scarring were included. Aphakic patients and patients with cataractous lens requiring IOL implantation surgery were excluded. Following preparation of the donor tissue, a corneal tunnel was made nasally with two side ports. All incisions were kept long enough to be overlapped by the peripheral part of the donor tissue...
April 2015: International Ophthalmology
Chris H L Lim, Andri K Riau, Nyein C Lwin, Shyam S Chaurasia, Donald T Tan, Jodhbir S Mehta
Presbyopia remains a major visual impairment for patients, who have previously undergone laser refractive correction and enjoyed unaided distance vision prior to the onset of presbyopia. Corneal stromal volume restoration through small incision lenticule extraction (SMILE) lenticule re-implantation presents an opportunity for restoring the patients' non-dominant eye to previous low myopia to achieve a monovision. In this study, we investigated the feasibility of performing LASIK after lenticule re-implantation as a method to create presbyopic monovision...
2013: PloS One
Kishore R Pradhan, Dan Z Reinstein, Glenn I Carp, Timothy J Archer, Marine Gobbe, Reeta Gurung
PURPOSE: To describe endokeratophakia in which a small incision lenticule extraction (SMILE) lenticule from a myopic patient is implanted into a recipient eye through a small incision to correct hyperopia. METHODS: A 23-year-old aphakic woman presented following cataract surgery to remove a childhood congenital cataract with hyperopia of +12.00 -1.50 × 155, corrected distance visual acuity of counting fingers, and exotropia. A SMILE procedure using the VisuMax femto-second laser (Carl Zeiss Meditec, Jena, Germany) was performed on a donor patient with high myopia and the extracted lenticule was stored (power -10...
November 2013: Journal of Refractive Surgery
Andri K Riau, Romesh I Angunawela, Shyam S Chaurasia, Wing S Lee, Donald T Tan, Jodhbir S Mehta
LASIK (laser-assisted in situ keratomileusis) is a common laser refractive procedure for myopia and astigmatism, involving permanent removal of anterior corneal stromal tissue by excimer ablation beneath a hinged flap. Correction of refractive error is achieved by the resulting change in the curvature of the cornea and is limited by central corneal thickness, as a thin residual stromal bed may result in biomechanical instability of the cornea. A recently developed alternative to LASIK called Refractive Lenticule Extraction (ReLEx) utilizes solely a femtosecond laser (FSL) to incise an intrastromal refractive lenticule (RL), which results in reshaping the corneal curvature and correcting the myopia and/or astigmatism...
2013: PloS One
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