Veena S Rao, Juan B Ivey-Miranda, Zachary L Cox, Julieta Moreno-Villagomez, Christopher Maulion, Lavanya Bellumkonda, John Chang, M Paul Field, Daniel R Wiederin, Javed Butler, Sean P Collins, Jeffrey M Turner, F Perry Wilson, Silvio E Inzucchi, Christopher S Wilcox, David H Ellison, Jeffrey M Testani
SIGNIFICANCE STATEMENT: The effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on regional tubular sodium handling is poorly understood in humans. In this study, empagliflozin substantially decreased lithium reabsorption in the proximal tubule (PT) (a marker of proximal tubular sodium reabsorption), a magnitude out of proportion to that expected with only inhibition of sodium-glucose cotransporter-2. This finding was not driven by an "osmotic diuretic" effect; however, several parameters changed in a manner consistent with inhibition of the sodium-hydrogen exchanger 3...
February 1, 2024: Journal of the American Society of Nephrology: JASN