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https://www.readbyqxmd.com/read/29040546/variation-and-functional-impact-of-neanderthal-ancestry-in-western-asia
#1
Recep Ozgur Taskent, Duha Alioglu, Evrim Fer, Handan Melike Donertas, Mehmet Somel, Omer Gokcumen
Neanderthals contributed genetic material to modern humans via multiple admixture events. Initial admixture events presumably occurred in Western Asia shortly after humans migrated out-of-Africa. Despite being a focal point of admixture, earlier studies indicate lower Neanderthal introgression rates in some Western Asian populations as compared to other Eurasian populations. To better understand the genome-wide and phenotypic impact of Neanderthal introgression in the region, we sequenced whole genomes of 10 present-day Europeans, Africans, and the Western Asian Druze at high depth, and analyzed available whole genome data from various other populations, including 16 genomes from present-day Turkey...
October 13, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29037026/treatment-outcomes-of-extended-field-radiation-therapy-for-thoracic-superficial-esophageal-cancer
#2
Doo Yeul Lee, Sung Ho Moon, Kwan Ho Cho, Tae Hyun Kim, Moon Soo Kim, Jong Yeul Lee, Yang-Gun Suh
PURPOSE: To evaluate the efficacy and safety of extended-field radiation therapy for patients with thoracic superficial esophageal cancer (SEC). MATERIALS AND METHODS: From May 2007 to October 2016, a total of 24 patients with thoracic SEC (T1a and T1b) who underwent definitive radiotherapy and were analyzed retrospectively. The median total radiotherapy dose was 64 Gy (range, 54 to 66 Gy) in conventional fractionation. All 24 patients received radiotherapy to whole thoracic esophagus and 23 patients received elective nodal irradiation...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29033765/celiac-disease-associated-with-a-benign-granulomatous-mass-demonstrating-self-regression-after-initiation-of-a-gluten-free-diet
#3
Abhinav Tiwari, Himani Sharma, Khola Qamar, Zubair Khan, Umar Darr, Anas Renno, Ali Nawras
Celiac disease is a chronic immune-mediated enteropathy in which dietary gluten induces an inflammatory reaction predominantly in the duodenum. Celiac disease is known to be associated with benign small bowel thickening and reactive lymphadenopathy that often regresses after the institution of a gluten-free diet. A 66-year-old male patient with celiac disease presented with abdominal pain and diarrheal illness. Computerized tomography of the abdomen revealed a duodenal mass. Endoscopic ultrasound-guided fine needle aspiration of the mass revealed bizarre stromal cells which represent a nonspecific tissue reaction to inflammation...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033254/nodal-areas-of-potential-geographic-error-in-adjuvant-radiotherapy-for-biliary-tract-cancer
#4
Joanna Socha, Maciej Michalak, Grzegorz Wołąkiewicz, Lucyna Kepka
PURPOSE: To determine the areas of potential geographic error in adjuvant radiotherapy (RT) for biliary-tract cancer (BTC) by comparing pathological-surgical data on the pattern of nodal spread with the extent of elective nodal CTV used in published RT studies in this setting. MATERIAL/METHODS: A literature search was performed to select articles on: 1/adjuvant RT for BTC, that provided information on the lymph node stations (LNS) included in the CTV; 2/the pathological-surgical data on the patterns of nodal involvement/recurrence in BTC...
October 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29030981/mesalazine-treatment-in-organotypic-culture-of-celiac-patients-comparative-study-with-gluten-free-diet
#5
EDITORIAL
Benedetti E, A Viscido, V Castelli, C Maggiani, M d'Angelo, E Di Giacomo, A Antonosante, A Picarelli, G Frieri
Given the central role of gluten in the pathogenesis of celiac disease (CD), a strict gluten-free diet (GFD) is the only validated treatment able to restore epithelium integrity and eliminate risks of complications. The risk of gluten contamination and the persistence of inflammation, even in patients strictly adhering to GFD, may render this treatment not always effective claiming the necessity of different new solutions. Oxidative and nitrosative stress have been indicated to play a pathophysiological role in CD...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29029421/prognostic-value-of-supraclavicular-nodes-and-upper-abdominal-nodes-metastasis-after-definitive-chemoradiotherapy-for-patients-with-thoracic-esophageal-squamous-cell-carcinoma
#6
Xue Li, Lujun Zhao, Wencheng Zhang, Chengwen Yang, Zhen Lian, Shuai Wang, Ningbo Liu, Qingsong Pang, Ping Wang, Jinming Yu
The purpose of this study is to assess the prognostic value of supraclavicular nodes, left gastric nodes, celiac nodes and common hepatic nodes metastasis in esophageal squamous cell carcinoma (ESCC) treated with definitive radiotherapy. A total of 293 ESCC patients treated with radiotherapy or chemoradiotherapy entered the study. The results showed that the presence of supraclavicular nodes (χ(2) = 0.075, P = 0.785) and left gastric nodes (χ(2) = 3.603, P = 0.058) metastasis had no significant influence on survival, while celiac nodes (χ(2) = 33...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026687/ascendobifemoral-bypass-for-the-treatment-of-a-thoracic-endograft-infection
#7
Sebastian Paul Pleger, Nadine Nink, Andreas Böning, Ahmed Koshty
Background  Endograft infections (EIs) are rare complications after endovascular procedures in the thoracic and abdominal aortas. The challenging treatment encloses antibiotic and surgical therapies. Case Description  A 74-year-old male patient developed an EI after an endovascular procedure (thoracic endovascular aortic repair [TEVAR]). Despite a long-term oral antibiotic therapy, the clinical symptoms showed no falling trend. Because of the expanded infection from above the celiac trunk up to the aortic arch, we decided to remove the infected endograft and to implant an extra-anatomic ascendobifemoral bypass...
January 2017: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/29026596/flow-cytometry-of-duodenal-intraepithelial-lymphocytes-improves-diagnosis-of-celiac-disease-in-difficult-cases
#8
Julio Valle, José Mario T Morgado, Juan Ruiz-Martín, Antonio Guardiola, Miriam Lopes-Nogueras, Almudena García-Vela, Beatriz Martín-Sacristán, Laura Sánchez-Muñoz
BACKGROUND: Diagnosis of celiac disease is difficult when the combined results of serology and histology are inconclusive. Studies using flow cytometry of intraepithelial lymphocytes (IELs) have found that celiac patients have increased numbers of γδ IELs, along with a decrease in CD3-CD103 + IELs. OBJECTIVE: The objective of this article is to assess the role of flow cytometric analysis of IELs in the diagnosis of celiac disease in difficult cases. METHODS: A total of 312 patients with suspicion of celiac disease were included in the study...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026595/time-trend-occurrence-of-duodenal-intraepithelial-lymphocytosis-and-celiac-disease-in-an-open-access-endoscopic-population
#9
Gloria Galli, Flaminia Purchiaroni, Edith Lahner, Maria Carlotta Sacchi, Emanuela Pilozzi, Vito Domenico Corleto, Emilio Di Giulio, Bruno Annibale
BACKGROUND: Duodenal intraepithelial lymphocytosis (DIL) is a histological finding characterized by the increase of intraepithelial CD3T-lymphocytes over the normal value without villous atrophy, mostly associated to coeliac disease (CD), Helicobacter pylori (Hp) gastritis and autoimmune diseases. OBJECTIVE: To assess the occurrence of DIL, CD and Hp gastritis in an endoscopic population over a 13 year period. METHODS: From 2003 to 2015 we included adult patients who consecutively underwent oesophago-gastro-duodenoscopy (OGD) with duodenal biopsies assessing the overall and annual occurrence of DIL and CD and the prevalence of Hp gastritis...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026594/subtypes-of-chronic-gastritis-in-patients-with-celiac-disease-before-and-after-gluten-free-diet
#10
Dolores Gabrieli, Fabiana Ciccone, Annalisa Capannolo, Angelo Viscido, Giorgio Valerii, Donatella Serva, Stefano Necozione, Gino Coletti, Giuseppe Calvisi, Dina Melideo, Giuseppe Frieri, Giovanni Latella
BACKGROUND: Celiac disease (CD) often manifests with dyspeptic symptoms and chronic gastritis is a common finding. AIM: To evaluate the frequency of lymphocytic gastritis (LG), chronic active gastritis (CAG), and chronic inactive gastritis (CIG) in patients with CD, before and after gluten-free diet (GFD). METHODS: A five-year prospective study including all consecutive patients with a new diagnosis of CD was conducted. Gastric and duodenal biopsy specimens taken both at the time of the CD diagnosis and at the first endoscopic control after 18-24 months on GFD were evaluated...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026365/incidental-finding-of-bronchopulmonary-sequestration-in-a-64-year-old-female
#11
Pichapong Tunsupon, Ayesha Arshad, Sumit Patel, M Jeffery Mador
BACKGROUND: Bronchopulmonary sequestration is a congenital abnormality of the primitive foregut. In adults, the typical age at presentation is 20-25 years. CASE REPORT: A 64-year-old female was referred for evaluation of an 8 × 6-cm right lower lobe cystic lesion. Her medical history was significant for recurrent right lower lobe pneumonia requiring multiple hospitalizations. Her physical examination was significant for crackles at the right lung base. Computed tomography (CT) of the chest with contrast showed cystic changes with thickened septation of the medial segment of the right lower lobe lacking distinct visceral pleura and with arterial supply from the anomalous branch of the thoracic aorta arising near the celiac trunk...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29023457/the-dmt1-ivs4-44c-a-polymorphism-and-the-risk-of-iron-deficiency-anemia-in-children-with-celiac-disease
#12
Carlo Tolone, Giulia Bellini, Francesca Punzo, Alfonso Papparella, Erasmo Miele, Alessandra Vitale, Bruno Nobili, Caterina Strisciuglio, Francesca Rossi
BACKGROUND: Iron deficiency anemia in celiac disease is related to impaired duodenal mucosal uptake, due to villous atrophy. Iron enters the enterocytes through an apical divalent metal transporter, DMT1. Different DMT1 transcripts have been identified, depending on the presence of an iron-responsive element that allows DMT1 up-regulation during iron starvation. An intronic DMT1 polymorphism, IVS4+44C>A, has been associated with metal toxicity, and the CC-carriers show high iron levels...
2017: PloS One
https://www.readbyqxmd.com/read/29022090/radiologic-evaluation-of-patients-undergoing-the-modified-appleby-procedure-for-locally-advanced-pancreatic-neoplasms-a-case-series
#13
Merel A T Vergauwen, Michele Perillo, Alejandro Garces-Descovich, Courtney E Barrows, A James Moser, Koenraad J Mortelé
PURPOSE: Despite advances in medical and surgical care, pancreatic ductal adenocarcinoma remains one of the most locally aggressive neoplastic processes in the abdomen. Unfortunately, most pancreatic adenocarcinomas present late and are unresectable at time of diagnosis. The modified Appleby procedure is a surgical option in patients with locally advanced pancreatic neoplasms of the body and tail with vascular invasion of the celiac trunk. To our knowledge, no radiologic journal has previously reported on the pre-operative evaluation or postoperative imaging findings of such patients...
October 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29020591/celiac-disease-and-autoimmunity-the-missing-ingredient
#14
COMMENT
James T Rosenbaum
New England Journal of Medicine, Volume 377, Issue 15, Page 1489-1490, October 2017.
October 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29018909/the-depth-from-the-skin-to-the-celiac-artery-measured-using-computed-tomography-is-a-simple-predictive-index-for-longer-operation-time-during-laparoscopic-distal-gastrectomy
#15
Hironobu Goto, Shingo Kanaji, Takashi Yasuda, Taro Oshikiri, Masashi Yamamoto, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yasuhiro Fujino, Masahiro Tominaga, Yoshihiro Kakeji
BACKGROUND: Body mass index (BMI) is commonly used to classify obesity. However, BMI does not always reflect the degree of visceral fat. This study aimed to clarify the usefulness of measuring the depth from the skin to the celiac artery using computed tomography, as a simple predictive index for longer operation time during laparoscopic distal gastrectomy (LDG). METHODS: From September 2012 to March 2016, 66 patients who underwent LDG with D1+ lymph node dissection were included...
October 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29018047/type-1-diabetes-and-celiac-disease-causal-association-or-true-true-unrelated
#16
Christine T Ferrara, Stephen E Gitelman
No abstract text is available yet for this article.
October 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/29018046/co-occurrence-of-type-1-diabetes-and-celiac-disease-autoimmunity
#17
William Hagopian, Hye-Seung Lee, Edwin Liu, Marian Rewers, Jin-Xiong She, Anette-G Ziegler, Åke Lernmark, Jorma Toppari, Stephen S Rich, Jeffrey P Krischer, Henry Erlich, Beena Akolkar, Daniel Agardh
BACKGROUND AND OBJECTIVES: Few birth cohorts have prospectively followed development of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities to determine timing, extent of co-occurrence, and associated genetic and demographic factors. METHODS: In this prospective birth cohort study, 8676 children at high genetic risk of both diseases were enrolled and 5891 analyzed in median follow-up of 66 months. Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed...
October 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/29016614/patterns-and-rates-of-abdominal-lymphatic-metastasis-following-esophageal-carcinoma
#18
Junqiang Chen, Wenjie Cai, Yu Lin, Yuanmei Chen, Qingfeng Zheng, Jianji Pan, Chuanben Chen
AIM: To determine the rate of abdominal lymph node metastasis after radical surgery for esophageal cancer and define the radiotherapy target area. METHODS: Of the 1593 patients who underwent R0 radical esophagectomy for thoracic esophageal squamous cell carcinoma (TE-SCC), 148 developed abdominal lymph node (LN) metastases within three years of surgery. During that time interval, patients were examined by various imaging methods (enhanced computer tomography, magnetic resonance imaging, and positron emission tomography-CT) at set time points...
2017: PloS One
https://www.readbyqxmd.com/read/29016564/the-role-of-an-iga-igg-deamidated-gliadin-peptide-point-of-care-test-in-predicting-persistent-villous-atrophy-in-patients-with-celiac-disease-on-a-gluten-free-diet
#19
Michelle S Lau, Peter D Mooney, William L White, Michael A Rees, Simon H Wong, Matthew Kurien, Nick Trott, Daniel A Leffler, Marios Hadjivassiliou, David S Sanders
OBJECTIVES: Mucosal healing is important in celiac disease (CD) for the prevention of complications. However, obtaining duodenal biopsies is invasive, and there is currently no reliable surrogate marker for histological remission in clinical practice. We aimed to assess the role of a point-of-care test (POCT) based on IgA/IgG-deamidated gliadin peptide, in detecting persistent villous atrophy (VA) in CD. METHODS: We prospectively recruited patients with CD attending endoscopy for the assessment of histological remission...
October 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28993260/improved-bone-microarchitecture-in-patients-with-celiac-disease-after-3-years-on-a-gluten-free-diet
#20
María B Zanchetta, Ana F Costa, Vanesa Longobardi, Roberto Mazure, Fernando Silveira, María P Temprano, Horacio Vázquez, César Bogado, Sonia I Niveloni, Edgardo Smecuol, María L Moreno, Andrea González, Eduardo Mauriño, José R Zanchetta, Julio C Bai
No abstract text is available yet for this article.
October 6, 2017: Clinical Gastroenterology and Hepatology
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