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https://www.readbyqxmd.com/read/28638884/anticancer-activity-of-5-7-dimethoxyflavone-against-liver-cancer-cell-line-hepg2-involves-apoptosis-ros-generation-and-cell-cycle-arrest
#1
Hengping Li, Xiaolei Zhang, Weixing Wang
BACKGROUND: Flavonoids are considered potential anticancer agents owing to their properties to interact with a diversity of cellular entities. Among flavonoids, methylated flavones are more efficient anticancer agents due to their higher stability in vivo. The purpose of the present study was, therefore, to evaluate the anticancer effect of methylated natural flavonoid 5, 7-dimethoxyflavone (5, 7-DMF). MATERIALS AND METHODS: MTT assay was used to determine the anticancer activity and IC50 of 5, -DMF)...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28633807/differential-induction-of-atf3-and-ho-1-in-myeloid-cells-and-keratinocytes-via-dimethylfumarate-or-cyclosporine-a
#2
Stefanie Müller, Nikola Smatlik, Marc Burian, Kamran Ghoreschi, Martin Röcken, Amir S Yazdi
BACKGROUND: Chronic inflammatory skin diseases are characterized by controlled proliferation of keratinocytes. Here, activating transcription factor 3 (ATF3) might play a fundamental role. In these inflammatory diseases, proliferation is controlled and only rarely leads to cancer development which can be supported by an inflammatory microenvironment. ATF3 is a dual function protein as it suppresses pro-inflammatory IL-6 and IL-8, but also acts as a pro-oncogenic factor by the suppression of p53...
June 12, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28631220/applicability-of-upflow-anaerobic-sludge-blanket-and-dynamic-membrane-coupled-process-for-the-treatment-of-municipal-wastewater
#3
Pei Jun Quek, Tsuey Shan Yeap, How Yong Ng
This study investigated the applicability of dynamic membrane filter (DMF) technology in an upflow anaerobic sludge blanket (UASB) and DMF-coupled process for the treatment of municipal wastewater. The overall treatment performance and effects of hydraulic retention time (HRT), operating flux, and mesh pore size on the UASB + DMF were assessed. The UASB + DMF-coupled process demonstrated removal efficiencies of over 64 and 86% for TCOD and TSS, respectively. The effects of filtration flux and support mesh pore size were investigated and it was found that while there was little impact on the treatment performance, a 67% increase in operating flux resulted in a 25% increase in fouling rate...
June 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28630257/contrasting-effects-of-medial-and-lateral-orbitofrontal-cortex-lesions-on-credit-assignment-and-decision-making-in-humans
#4
MaryAnn P Noonan, Bolton Chau, Matthew Fs Rushworth, Lesley K Fellows
The orbitofrontal cortex is critical for goal-directed behavior. Recent work in macaques has suggested the lateral orbitofrontal cortex (lOFC) is relatively more concerned with assignment of credit for rewards to particular choices during value-guided learning, while the medial orbitofrontal cortex (often referred to as ventromedial prefrontal cortex in humans; vmPFC/mOFC) is involved in constraining the decision to the relevant options. We examined whether people with damage restricted to sub-regions of prefrontal cortex showed the patterns of impairment observed in prior investigations of the effects of lesions to homologous regions in macaques...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28623862/stimuli-responsive-mof-with-chemo-switchable-properties-for-colorimetric-detection-of-chcl3
#5
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Ali Morsali
The ligands (3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine), H2DPT, as a pillar spacer and (4,4'-oxybis(benzoic acid)), H2OBA, as a dicarboxylate linker were used to develop a dihydro-tetrazine functionalized pillared-MOF, [Zn(OBA)(H2DPT)0.5].DMF (TMU-34) as functionally convertible stimuli responsive MOF-based Sensor. Sonochemically synthesized powder of TMU-34 was employed in sensing of volatile organic compounds (VOCs). The results show that TMU-34 can act as a solid state naked-eye visual chemosensor for detection of chloroform in liquid and gas phases...
June 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28622566/crosslinking-hydroxylated-reduced-graphene-oxide-with-raft-cta-a-nano-initiator-for-preparation-of-well-defined-amino-acid-based-polymer-nanohybrids
#6
Mina Namvari, Chandra S Biswas, Qiao Wang, Wenlang Liang, Florian J Stadler
Here, we demonstrate a novel reversible addition-fragmentation chain transfer agent (RAFT-CTA)-modified reduced graphene oxide nanosheets (CTA-rGONSs) by crosslinking rGONSs with a RAFT-CTA via esterification reaction. These nano CTA-rGONSs were used to polymerize a hydrophobic amino acid-based methacrylamide (N-acryloyl-l-phenylalanine methyl ester) monomer with different monomer/initiator ratios. Thermogravimetric analysis showed that the polymer-graphene composites were thermally more stable than GO itself...
June 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28621710/a-recyclable-cu-mof-74-catalyst-for-the-ligand-free-o-arylation-reaction-of-4-nitrobenzaldehyde-and-phenol
#7
Pedro Leo, Gisela Orcajo, David Briones, Guillermo Calleja, Manuel Sánchez-Sánchez, Fernando Martínez
The activity and recyclability of Cu-MOF-74 as a catalyst was studied for the ligand-free C-O cross-coupling reaction of 4-nitrobenzaldehyde (NB) with phenol (Ph) to form 4-formyldiphenyl ether (FDE). Cu-MOF-74 is characterized by having unsaturated copper sites in a highly porous metal-organic framework. The influence of solvent, reaction temperature, NB/Ph ratio, catalyst concentration, and basic agent (type and concentration) were evaluated. High conversions were achieved at 120 °C, 5 mol % of catalyst, NB/Ph ratio of 1:2, DMF as solvent, and 1 equivalent of K₂CO₃ base...
June 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28616942/two-tetraphenylethene-containing-coordination-polymers-for-reversible-mechanochromism
#8
Si-Si Zhao, Li Chen, Lei Wang, Zhigang Xie
Two fluorescent coordination polymers have been designed and synthesized from a tetraphenylethene (TPE) derivative. These polymers, which can be potentially utilized as mechanical sensors, exhibit reversible mechanochromic luminescence with color changes visible to the naked-eye from blue to green-yellow by grinding or soaking in N,N-dimethylformamide (DMF) under UV irradiation.
June 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28616149/is-iron-unique-in-promoting-electrical-conductivity-in-mofs
#9
Lei Sun, Christopher H Hendon, Sarah S Park, Yuri Tulchinsky, Ruomeng Wan, Fang Wang, Aron Walsh, Mircea Dincă
Identifying the metal ions that optimize charge transport and charge density in metal-organic frameworks is critical for systematic improvements in the electrical conductivity in these materials. In this work, we measure the electrical conductivity and activation energy for twenty different MOFs pertaining to four distinct structural families: M2(DOBDC)(DMF)2 (M = Mg(2+), Mn(2+), Fe(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+)); H4DOBDC = 2,5-dihydroxybenzene-1,4-dicarboxylic acid; DMF = N,N-dimethylformamide), M2(DSBDC)(DMF)2 (M = Mn(2+), Fe(2+); H4DSBDC = 2,5-disulfhydrylbenzene-1,4-dicarboxylic acid), M2Cl2(BTDD)(DMF)2 (M = Mn(2+), Fe(2+), Co(2+), Ni(2+); H2BTDD = bis(1H-1,2,3-triazolo[4,5-b],[4',5'-i]dibenzo[1,4]dioxin), and M(1,2,3-triazolate)2 (M = Mg(2+), Mn(2+), Fe(2+), Co(2+), Cu(2+), Zn(2+), Cd(2+))...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28612110/differential-killing-and-radio-modifying-effects-of-iodoacetate-in-mammalian-normal-and-cancer-cells
#10
Usha Yadav, K B Anjaria, Rajesha Nairy, K B Shirsath, Utkarsha N Desai, Rajesh K Chaurasia, Nagesh N Bhat, B K Sapra
To explore possible applications of iodoacetate (IA), a glycolytic inhibitor, in cancer treatment, we screened its cytotoxicity and radioprotective/sensitizing efficacy in three different mammalian cell lines; A549 (human lung carcinoma), MCF7 (human mammary cancer), a non-cancerous CHO (Chinese hamster ovary) cells and human lymphocytes. Experiments were carried out using IA concentrations ranging from 0.01 to 2.5 µg/ml, with or without (60)Coγ-radiation. In the outcomes, IA was found to exhibit higher toxicity in the cancer cells, whereas it was non-toxic/marginally toxic to the non-cancerous cells...
June 13, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28607757/lymphocyte-subtypes-in-relapsing-remitting-multiple-sclerosis-patients-treated-with-dimethyl-fumarate
#11
C Chaves, R Ganguly, C Ceresia, A Camac
BACKGROUND: Recent data suggest that lymphopenia is more prevalent than reported in relapsing-remitting multiple sclerosis (RRMS) patients taking dimethyl fumarate (DMF). OBJECTIVE: The objective of this study was to investigate the effect of DMF on lymphocyte subtypes in RRMS patients with and without lymphopenia. METHOD: A retrospective study compared lymphocyte subtypes in DMF-treated RRMS patients with low (G1, n = 35) and normal lymphocyte counts (G2, n = 24)...
April 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28606007/dimethyl-fumarate-improves-white-matter-function-following-severe-hypoperfusion-involvement-of-microglia-macrophages-and-inflammatory-mediators
#12
Jill H Fowler, Jamie McQueen, Philip R Holland, Yasmina Manso, Martina Marangoni, Fiona Scott, Emma Chisholm, Robert H Scannevin, Giles E Hardingham, Karen Horsburgh
The brain's white matter is highly vulnerable to reductions in cerebral blood flow via mechanisms that may involve elevated microgliosis and pro-inflammatory pathways. In the present study, the effects of severe cerebral hypoperfusion were investigated on white matter function and inflammation. Male C57Bl/6J mice underwent bilateral common carotid artery stenosis and white matter function was assessed at seven days with electrophysiology in response to evoked compound action potentials (CAPs) in the corpus callosum...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28605412/accuracy-profiles-for-analyzing-residual-solvents-in-textiles-by-gc-ms
#13
Qibei Bao, Kejie Fu, Qingqing Ren, Yingying Zhong, Dan Qian
Excess residual solvents (RSs) in clothes or other textiles could be toxic and pose risks to both humans and the environment. N,N-Dimethylformamide (DMF), N,N-dimethylacetamide (DMAc) and 1-methyl-2-pyrrolidinone (NMP) are important chemicals frequently used as solvents in the textile industry. Several organizations have proposed limiting DMF, DMAc and NMP in textiles, but an appropriate detection method has not been proposed. A sensitive GC-MS method for the quantification of DMF, DMAc and NMP in textiles was developed...
June 9, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28604907/solvent-dependent-selective-cation-exchange-in-anionic-frameworks-based-on-cobalt-ii-and-triphenylamine-linkers-reactor-dependent-synthesis-and-sorption-properties
#14
Oluseun Akintola, David Hornig, Axel Buchholz, Helmar Görls, Winfried Plass
Two cobalt(ii) coordination polymers with anionic networks of formulae {(Me2NH2)2[CoCl(ntb)]}n (JUMP-2) and {(Me2NH2)2[Co5(ntb)4(H2O)3(Me2NH)]}n (previously reported as MIL-144 by Livage et al., Microporous Mesoporous Mater., 2012, 157, 37) have been obtained via a solvothermal reaction of cobalt chloride and 4,4',4''-nitrilotribenzoic acid (H3ntb) in DMF employing two differently-sized reactors, while using the same absolute amount of reactants. Structure analysis revealed that JUMP-2 crystallized in the monoclinic space group P21/n and displays a two-dimensional (2D) network, which by topological analysis was characterized as a layered 3-connected hcb net...
June 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28602891/manufacture-of-autologous-cd34-selected-grafts-in-the-niaid-sponsored-halt-ms-and-scot-multicenter-clinical-trials-for-autoimmune-diseases
#15
Carolyn A Keever-Taylor, Shelly Heimfeld, Kaitlyn C Steinmiller, Richard A Nash, Keith M Sullivan, Christine W Czarniecki, Tomeka C Granderson, Julia S Goldstein, Linda M Griffith
To ensure comparable grafts for autologous HCT in NIAID-sponsored IND protocols for multiple sclerosis (HALT-MS) and systemic sclerosis (SCOT), a DMF approach to control manufacture was implemented, including a common Master Production Batch Record, and site-specific SOPs with "Critical Elements". We assessed comparability of flow cytometry and controlled rate cryopreservation among sites, and stability of cryopreserved grafts, using hematopoietic progenitor cells (HPC) from healthy donors. Auto-CD34+HPC graft specifications included ≥70% viable CD34+ cells before cryopreservation...
June 5, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28602832/fumarate-decreases-edema-volume-and-improves-functional-outcome-after-experimental-stroke
#16
Bettina Hjelm Clausen, Louise Lundberg, Minna Yli-Karjanmaa, Nellie Anne Martin, Martina Svensson, Maria Zeiler Alfsen, Simon Bertram Flæng, Kristina Lyngsø, Antonio Boza-Serrano, Helle H Nielsen, Pernille B Hansen, Bente Finsen, Tomas Deierborg, Zsolt Illes, Kate Lykke Lambertsen
BACKGROUND: Oxidative stress and inflammation exacerbate tissue damage in the brain after ischemic stroke. Dimethyl-fumarate (DMF) and its metabolite monomethyl-fumarate (MMF) are known to stimulate anti-oxidant pathways and modulate inflammatory responses. Considering these dual effects of fumarates, we examined the effect of MMF treatment after ischemic stroke in mice. METHODS: Permanent middle cerebral artery occlusion (pMCAO) was performed using adult, male C57BL/6 mice...
June 8, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28598483/the-photocurrent-response-in-the-perovskite-device-based-on-coordination-polymers-structure-topology-band-gap-and-matched-energy-levels
#17
Hai-Qiang Luo, Xiao-Han Xing, Pan Zhang, Zhi-Shuo Yan, Qing-Feng Zhou, Yun Gong, Jian-Hua Lin
Using a rigid ditopic ligand, 4,5-di(4'-carboxylphenyl)benzene (H2L), three coordination polymers (CPs) formulated as MnL(H2O)2 (1), CdL(H2O) (2) and Mn2L2(DMF)3 (3) have been synthesized and structurally characterized by single-crystal X-ray diffraction. These three CPs display 2D architectures but with different topologies. The experimental data and DFT calculation indicate that CP 2 is a semiconductor, and its CB/VB energy levels match with those of the perovskite CH3NH3PbI3. A FTO/TiO2/CH3NH3PbI3/CP 2 device is fabricated and the CP-based device shows much larger photoresponse under visible light illumination (650 nm > λ > 350 nm, 100 mW cm(-2)) than the individual CP 2...
June 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28597547/controlled-growth-of-monocrystalline-organo-lead-halide-perovskite-and-its-application-in-photonic-devices
#18
Wenxin Mao, Jialu Zheng, Yupeng Zhang, Anthony S R Chesman, Qingdong Ou, Jamie Hicks, Feng Li, Ziyu Wang, Brenton Graystone, Toby Bell, Mathias Uller Rothmann, Noel Duffy, Yibing Cheng, Leone Spiccia, Qiaoliang Bao, Udo Bach
Organo-lead halide perovskites as a new class of exceptional optoelectronic materials has been found use in many applications. However, conventional methods for forming single crystals of OHPs afford limited control over the product morphology, rendering the assembly of defined microstructures difficult. We overcame this by synthesising for the first time (MA)[PbBr3]·DMF (1), and demonstrating its facile transformation into monocrystalline MAPbBr3 microplatelets, which exhibit excellent waveguiding porperty with an ultra-low propagation loss of 0...
June 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28589165/effects-of-fumarates-on-inflammatory-human-astrocyte-responses-and-oligodendrocyte-differentiation
#19
Dylan A Galloway, John B Williams, Craig S Moore
OBJECTIVE: Dimethyl fumarate (DMF) is a fumaric acid ester approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). In both the brain and periphery, DMF and its metabolite monomethyl fumarate (MMF) exert anti-inflammatory and antioxidant effects. Our aim was to compare the effects of DMF and MMF on inflammatory and antioxidant pathways within astrocytes, a critical supporting glial cell in the central nervous system (CNS). Direct effects of fumarates on neural progenitor cell (NPC) differentiation toward the oligodendrocyte lineage were also assessed...
June 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28585895/an-examination-of-mce-filter-morphology-and-implications-on-preparation-and-analysis-of-air-samples-for-asbestos
#20
Myron Getman, James Webber, Samuel Bowser
Morphological imperfections of mixed-cellulose ester filters and their possible influence on sample preparation and analysis of asbestos were examined. Filters were identified with large regions of non-porous "dead zones" which could negatively affect fiber deposition and, therefore, fiber recovery and analysis by Transmission Electron Microscopy (TEM). As these imperfections are effectively erased during the preparation of the sample, they may not be readily observed by TEM. Un-collapsed filters as well as those collapsed using dimethylformamide (DMF) and two acetone techniques were examined...
June 6, 2017: Journal of Occupational and Environmental Hygiene
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