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https://www.readbyqxmd.com/read/28926039/tuning-linkage-isomerism-and-magnetic-properties-of-bi-and-tri-metallic-cage-silsesquioxanes-by-cation-and-solvent-effects
#1
Alexey N Bilyachenko, Alexander A Korlyukov, Anna V Vologzhanina, Victor N Khrustalev, Alena N Kulakova, Jérôme Long, Joulia Larionova, Yannick Guari, Marina S Dronova, Ulyana S Tsareva, Pavel V Dorovatovskii, Elena S Shubina, Mikhail M Levitsky
Herein, the effect of replacement of the surrounding solvent and/or the partial substitution of sodium ions in the cage-like copper, sodium phenylsilsesquioxane [(PhSiO1.5)12(CuO)4(NaO0.5)4(n-BuOH)6] 1 with a globular structure was investigated; the synthesis of ten new derivatives of complex 1 was performed, and their crystal structures were determined. Solvate replacement of n-butanol in 1 with dimethyl sulfoxide, acetonitrile, 1,4-dioxane/EtOH, and 1,4-dioxane/PhCN afforded the complexes [(PhSiO1.5)12(CuO)4(NaO0...
September 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28923384/synthesis-and-structure-elucidation-of-novel-salophen-based-dioxo-uranium-vi-complexes-in-vitro-and-in-silico-studies-of-their-dna-bsa-binding-properties-and-anticancer-activity
#2
S Yousef Ebrahimipour, Maryam Mohamadi, Masoud Torkzadeh Mahani, Jim Simpson, Joel T Mague, Iran Sheikhshoaei
The synthesis and characterization of three dioxo U(VI) complexes, [UO2(L(1))(OH2)], [UO2(L(2))DMF], and [UO2(L(2))DMSO], [L(1)](2-) = 1,1'-(4-methyl-1,2-phenylenebis (nitrilomethylidyne))di-2-naphtholate: [L(2)](2-) = 1,1'-(o-phenylenebis (nitrilomethylidyne)) di-2-naphtholate, are reported. Elemental analysis, FT-IR, (1)HNMR, UV-Vis spectroscopy, molar conductivity and single crystal X-ray diffraction were used to characterize the complexes. It was found that the complexes adopt a distorted pentagonal bipyramidal coordination geometry...
September 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28921587/dimethyl-fumarate-treatment-after-traumatic-brain-injury-prevents-depletion-of-antioxidative-brain-glutathione-and-confers-neuroprotection
#3
Tobias Krämer, Theresa Grob, Lutz Menzel, Tobias Hirnet, Eva Griemert, Konstantin Radyushkin, Serge C Thal, Axel Methner, Michael K E Schaefer
Dimethyl fumarate (DMF) is an immunomodulatory therapeutic for multiple sclerosis and psoriasis with neuroprotective potential. Its mechanism of action involves activation of the antioxidant pathway regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) thereby increasing synthesis of the cellular antioxidant glutathione (GSH). The objective of this study was to investigate whether post-traumatic DMF treatment is beneficial after experimental traumatic brain injury (TBI). Adult C57Bl/6 mice were subjected to controlled cortical impact followed by oral administration of DMF (80 mg/kg body weight) or vehicle at 3 h, 24 h, 48 h and 72 h after the inflicted TBI...
September 16, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28920991/single-ion-magnetism-in-seven-coordinate-yb-iii-complexes-with-distorted-d5h-coordination-geometry
#4
Dong-Qing Wu, Dong Shao, Xiao-Qin Wei, Fu-Xing Shen, Le Shi, Yi-Quan Zhang, Xin-Yi Wang
Two seven-coordinate compounds with pentagonal bipyramidal Yb(III) centers, namely, [Yb(H3Bmshp)(DMF)2Cl2]·DMF·1.5H2O (1) and [Yb(H3Bmshp)(DMF)2Cl2]·H4Bmshp (2) (H4Bmshp = (2,6-bis[(3-methoxysalicylidene)hydrazinecarbonyl]-pyridine)) were synthesized by changing the molar ratio of reactants in DMF. The structures of compounds 1 and 2 are very similar, except for the existence of different lattice molecules: one DMF and one and a half water molecules in 1, and one neutral uncoordinated ligand in 2. The coordination geometries of both the pentagonal bipyramidal Yb(III) centers (YbCl2N1O4) in compounds 1 and 2 are also very similar with only slight differences...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28918452/pro-oxidant-status-and-nrf2-levels-in-psoriasis-vulgaris-skin-tissues-and-dimethyl-fumarate-treated-hacat-cells
#5
Yoon Jin Lee, Jin Ho Bae, Sang-Gue Kang, Sung Woo Cho, Dong-Il Chun, Seung Min Nam, Chul Han Kim, Hae Seon Nam, Seon Hwa Lee, Sang Han Lee, Moon Kyun Cho
Reactive oxygen species (ROS) contribute to pathogenesis of many inflammatory skin diseases, including psoriasis. The aim of this study is to compare antioxidant protein expression in psoriasis vulgaris (PV) skin tissues with that in normal skin tissues in vivo and to evaluate the effects of dimethyl fumarate (DMF), used for the treatment of psoriasis, on ROS generation and apoptosis in a human keratinocyte cell line HaCaT. Compared with normal skin tissues, PV skin tissues showed increased protein oxidation as well as down-regulation of Nrf2 and its regulatory proteins such as HO-1 and AKR1C3...
September 16, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28917448/in-vitro-antitumor-activity-of-novel-benzimidazole-based-cu-ii-complexes
#6
Jiyong Hu, Yan Guo, Jin'an Zhao, Junshuai Zhang
Four benzimidazole-based Cu(II) complexes: Cu2(p-2-bmp)2Br4 (1), Cu2(p-2-bmp)2Cl4 (2), Cu2(p-2-bmb)2(DMF)2Br4·(CHCl3) (3), and Cu(p-2-bmb)(NO3)2·(CHCl3) (4) were isolated and characterized, where p-2-bmp is 1-((2-(pyridine-2-yl)-1H-benzoimidazol-1-yl)methyl)-1H-pyridine and p-2-bmb is 1-((2-(pyridin-2-yl)-1-benzoimidazol-1-yl)methyl)-1H-benzotriazole. Complexes 1 and 2 have binuclear configurations, 3 has a mononuclear structure, and 4has a one-dimensional (1-D) chain skeleton. To evaluate their potential anticancer effects on human carcinoma cells, anti-proliferation, DNA binding and cleavage, and apoptosis elicitation were examined...
September 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28915022/cobalt-ii-ions-connecting-co-ii-4-helicates-into-a-2-d-coordination-polymer-showing-slow-relaxation-of-the-magnetization
#7
Paula Cucos, Lorenzo Sorace, Catalin Maxim, Sergiu Shova, Delia Patroi, Andrea Caneschi, Marius Andruh
The reactions of cobalt(II) perchlorate with a diazine tetratopic helicand, H4L, in the presence of sodium carbonate afford two coordination polymers constructed from tetranuclear anionic helicates as building blocks: ∞(3)[Co4L3Na4(H2O)4]·4H2O (1) and ∞(2)[Co5L3Na2(H2O)9]·2.7H2O·DMF (2). The tetranuclear triple-stranded helicates, {Co(II)4L3}(4-), are connected in 1 by sodium(I) ions and in 2 by sodium(I) and cobalt(II) ions (H4L results from the condensation reaction between 3-formylsalicylic acid and hydrazine)...
September 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28914496/silver-thiolate-nano-sized-molecular-clusters-and-their-supramolecular-covalent-frameworks-an-approach-toward-pre-templated-synthesis
#8
Zi-Yi Chen, Dennis Y S Tam, Leon Li-Min Zhang, Thomas Chung Wai Mak
A series of seven new complexes including silver-thiolate molecular clusters and their covalent supramolecular frameworks have been assembled from the silver carbide precursor Ag2C2 using a C22- pre-templated approach. Herein, two prototype clusters Ag14(SR)6 and CO3@Agm(SR)10 (R = isopropyl, cyclohexyl or tert-butyl; m = 18 or 20) are employed to construct cluster-based metal-organic frameworks of different dimensions. In particular, both new ellipsoidal tetradecanuclear molecular cluster compounds, namely Ag14(S-iPr)6(CF3CO2)8·DMSO6 (two polymorphic forms 1, 2) and [Ag14(S-Cy)6(CO2CF3)8(DMSO)4] · DMSO3 (3), and a cluster-based metal-organic framework {Ag3[Ag14(S-iPr)6(CF3CO2)11(H2O)3CH3OH] · (H2O)2...
September 15, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28911982/upper-aerodigestive-tract-cancer-and-oral-health-status-before-radiotherapy-a-cross-sectional-study-of-154-patients
#9
A Raskin, M Ruquet, L Weiss-Pelletier, J Mancini, O Boulogne, J Michel, N Fakhry, J M Foletti, C Chossegros, R Giorgi
OBJECTIVES: We aimed to determine primarily the oral health status of patients with upper aerodigestive tract cancer before radiotherapy, and secondarily the prevalence of risk factors for poor oral status. METHODS: A cross-sectional study was conducted in Marseille University hospital. Assessment criteria were the Decay, Missing and Filled (DMF) index and periodontal status. RESULTS: One hundred and fifty-four patients, mean age 60.9 years, were included...
September 11, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28906152/relapse-outcomes-safety-and-treatment-patterns-in-patients-diagnosed-with-relapsing-remitting-multiple-sclerosis-and-initiated-on-subcutaneous-interferon-%C3%AE-1a-or-dimethyl-fumarate-a-real-world-study
#10
Frank R Ernst, Peri Barr, Riad Elmor, Schiffon L Wong
OBJECTIVE: To estimate real-world treatment patterns, safety, and relapse outcomes of subcutaneous (sc) interferon (IFN) β-1a (Rebif®) versus dimethyl fumarate (DMF; Tecfidera(®)), to treat relapsing-remitting multiple sclerosis (RRMS). METHODS: A U.S. retrospective chart review of 450 randomly selected adults newly diagnosed with RRMS who received sc IFN β-1a (n = 143) or DMF (n = 307) was conducted. Patients were either (a) treatment-naïve, initiating first-line treatment with sc IFN β-1a or DMF, or (b) previously treated, switching to sc IFN β-1a or DMF...
September 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28901358/cadmium-1-4-cyclohexanedicarboxylato-coordination-polymers-bearing-different-di-alkyl-2-2-bipyridines-syntheses-crystal-structures-and-photoluminescence-studies
#11
Luis D Rosales-Vázquez, Víctor Sánchez-Mendieta, Alejandro Dorazco-González, Diego Martínez-Otero, Iván García-Orozco, Raúl A Morales-Luckie, Jonathan Jaramillo-Garcia, Antonio Téllez-López
Four coordination polymers have been synthesized using self-assembly solution reactions under ambient conditions, reacting Cd(ii) ions with 1,4-cyclohexanedicarboxylic acid in the presence of different 2,2'-bipyridine co-ligands: {[Cd(H2O)(e,a-cis-1,4-chdc)(2,2'-bpy)]·H2O}n (1); [Cd2(H2O)2(e,a-cis-1,4-chdc)2(4,4'-dmb)2]n (2); {[Cd(e,a-cis-1,4-chdc)(5,5'-dmb)]·H2O·CH3OH}n (3) and {[Cd(e,e-trans-1,4-chdc)(4,4'-dtbb)]·CH3OH}n (4), where 1,4-chdc = 1,4-cyclohexanedicarboxylato, 2,2'-bpy = 2,2'-bipyridine, 4,4'-dmb = 4,4'-dimethyl-2,2'-bipyridine, 5,5'-dmb = 5,5'-dimethyl-2,2'-bipyridine and 4,4'-dtbb = 4,4'-di-tert-butyl-2,2'-bipyridine...
September 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28901042/calcium-coordination-solids-for-ph-triggered-release-of-olsalazine
#12
Dana Jaya Levine, Miguel I Gonzalez, Christina M Legendre, Tomče Runčevski, Julia Oktawiec, Kristen A Colwell, Jeffrey R Long
Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H₄olz), an anti-inflammatory compound used for treatment of ulcerative colitis. The materials include one-dimensional Ca(H₂olz)·4H₂O chains, two-dimensional Ca(H₂olz)·2H₂O sheets, and a three-dimensional metal-organic framework Ca(H₂olz)·2DMF (DMF = N,N-dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H₂olz) phase when exposed to aqueous HCl. The compounds Ca(H₂olz)·xH₂O (x = 0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH-neutral intestines...
September 12, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28900067/-dimethyl-fumarate-in-multiple-sclerosis
#13
Masami Tanaka, Yuko Shimizu
At the end of 2016, dimethyl fumarate (DMF) was approved as the sixth disease-modifying drug for multiple sclerosis by the Pharmaceuticals and Medical Devices Agency of Japan. Two randomized, placebo-controlled, phase III studies (DEFINE and CONFIRM) showed beneficial effects in patients in Western countries, with relapsing-remitting multiple sclerosis (RRMS). Some of the benefits included a decreased annual relapse rate, inhibition of disease activity (shown using brain magnetic resonance imaging), and a decreased proportion of patients with confirmed disease progression...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28885741/fused-1-2-3-thiaselenazoles-synthesized-from-1-2-3-dithiazoles-via-selective-chalcogen-exchange
#14
Lidia S Konstantinova, Ilia V Baranovsky, Elena A Pritchina, Maksim S Mikhailov, Irina Yu Bagryanskaya, Nikolay A Semenov, Irina G Irtegova, Georgy E Salnikov, Konstantin A Lyssenko, Nina P Gritsan, Andrey V Zibarev, Oleg A Rakitin
A new approach to the synthesis of variously fused 1,2,3-thiaselenazoles, i.e. rare 5-membered heterocycles with two different chalcogens, from the corresponding 1,2,3-dithiazoles and selenium dioxide has been accomplished via selective exchange of S and Se atoms. The fused carbo- and heterocycles were indene, naphthalenone, cyclohexadienone, cyclopentadiene, benzoannulene and benzoxazine. Molecular structures of thiaselenadiazoles 2 and 12 and dithia precursor 7 of the latter were confirmed by single-crystal X-ray diffraction...
September 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28880527/two-analogous-polyhedron-based-mofs-with-high-density-of-lewis-basic-sites-and-open-metal-sites-significant-co2-capture-and-gas-selectivity-performance
#15
Bing Liu, Shuo Yao, Xinyao Liu, Xu Li, Rajamani Krishna, Guanghua Li, Qisheng Huo, Yunling Liu
By means of modulating the axial ligand and adopting supermolecular building blocks (SBBs) strategy, two polyhedron-based metal-organic frameworks (PMOFs) have been successfully synthesized [Cu6(C17O9N2H8)3(C6H12N2)(H2O)2(DMF)2]·3DMF·8H2O (JLU-Liu46) and [Cu6(C17O9N2H8)3(C4H4N2)(H2O)2(DMF)2]·3DMF·8H2O (JLU-Liu47), which possess a high density of Lewis basic sites (LBSs) and open metal sites (OMSs). Since the size of axial ligand in JLU-Liu47 is smaller than that in JLU-Liu46, JLU-Liu47 shows larger pore volume and higher BET surface area...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28873360/bioanalysis-of-monomethyl-fumarate-in-human-plasma-by-a-sensitive-and-rapid-lc-ms-ms-method-and-its-pharmacokinetic-application-lc-ms-ms-determination-of-monomethyl-fumarate-in-human-plasma
#16
Imam Pasha S, Murali Balaram Varanasi, Ibrahim Mohammed
Dimethyl fumarate (DMF) is the methyl ester of fumaric acid, after oral administration completely converts to its active metabolite monomethyl fumarate (MMF). A simple, rapid and sensitive LC-MS/MS method was developed and validated for the quantification of MMF in human plasma. Monomethyl fumarate d3 was used as an internal standard (IS). The analyte and the IS were extracted from plasma using a selective solid phase extraction technique. The clean samples were chromatographed on a C18 column using formic acid and acetonitrile (25:75, v/v) as mobile phase...
August 23, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28871290/image-based-feedback-and-analysis-system-for-digital-microfluidics
#17
Philippe Q N Vo, Mathieu C Husser, Fatemeh Ahmadi, Hugo Sinha, Steve C C Shih
Digital microfluidics (DMF) is a technology that provides a means of manipulating nL-μL volumes of liquids on an array of electrodes. By applying an electric potential to an electrode, these discrete droplets can be controlled in parallel which can be transported, mixed, reacted, and analyzed. Typically, an automation system is interfaced with a DMF device that uses a standard set of basic instructions written by the user to execute droplet operations. Here, we present the first feedback method for DMF that relies on imaging techniques that will allow online detection of droplets without the need to reactivate all destination electrodes...
September 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28871145/reversible-keap1-inhibitors-are-preferential-pharmacological-tools-to-modulate-cellular-mitophagy
#18
Nikolaos D Georgakopoulos, Michele Frison, Maria Soledad Alvarez, Hélène Bertrand, Geoff Wells, Michelangelo Campanella
Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without collapsing their membrane potential (ΔΨm). PMI is an inhibitor of the protein-protein interaction (PPI) between the transcription factor Nrf2 and its negative regulator, Keap1 and is able to up-regulate the expression of autophagy-associated proteins, including p62/SQSTM1...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870693/therapeutic-targeting-of-taz-and-yap-by-dimethyl-fumarate-in-systemic-sclerosis-fibrosis
#19
Tetsuo Toyama, Agnieszka P Looney, Brendon M Baker, Lukasz Stawski, Paul Haines, Robert Simms, Aleksander D Szymaniak, Xaralabos Varelas, Maria Trojanowska
Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera®) have shown therapeutic effects in several disease models, prompting us to determine whether DMF is effective as a treatment for SSc dermal fibrosis. We found that DMF blocks the pro-fibrotic effects of TGFβ in SSc skin fibroblasts. Mechanistically, we found that DMF treatment reduced nuclear localization of TAZ and YAP proteins via inhibition of PI3-K/Akt1 pathway...
September 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28869262/the-effects-of-exfoliation-organic-solvents-and-anodic-activation-on-the-catalytic-hydrogen-evolution-reaction-of-tungsten-disulfide
#20
Wanglian Liu, John Benson, Craig Dawson, Andrew Strudwick, Arun Prakash Aranga Raju, Yisong Han, Meixian Li, Pagona Papakonstantinou
The rational design of transition metal dichalcogenide electrocatalysts for efficiently catalyzing the hydrogen evolution reaction (HER) is believed to lead to the generation of a renewable energy carrier. To this end, our work has made three main contributions. At first, we have demonstrated that exfoliation via ionic liquid assisted grinding combined with gradient centrifugation is an efficient method to exfoliate bulk WS2 to nanosheets with a thickness of a few atomic layers and lateral size dimensions in the range of 100 nm to 2 nm...
September 4, 2017: Nanoscale
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