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Jenny Abanto, Evelyn Alvarez Vidigal, Thiago Saads Carvalho, Stella Núbia Coelho de Sá, Marcelo Bönecker
The aim of this study was to assess the clinical and socioeconomic indicators associated with dental anxiety in preschool children with severe dental caries. A total of 100 children between 3 and 5 years of age were selected during a dental screening procedure. The selection criteria were having at least one tooth with dental caries and a visible pulpal involvement, ulceration, fistula, and abscess (PUFA) index of ≥1 in primary teeth. Before the clinical examination or any treatment procedure was performed, we evaluated the children's dental anxiety using the Facial Image Scale (FIS)...
January 16, 2017: Brazilian Oral Research
Andrew Lee, James Pike, Michael R Edwards, Jennifer Petrillo, John Waller, Eddie Jones
INTRODUCTION: Dimethyl fumarate (DMF) is a novel oral therapy used for the treatment of relapse-remitting multiple sclerosis (RRMS). In two 2-year pivotal Phase 3 trials in patients with RRMS, DMF significantly reduced disease activity based on both clinical and magnetic resonance imaging (MRI) findings and demonstrated an acceptable safety profile. However, there is currently a lack of comparative data which explore the relationship between work productivity and health-related quality of life (HRQoL) outcomes in RRMS and how these differ among RRMS therapies, including DMF...
January 16, 2017: Neurology and Therapy
Hongwei Wu, Pei Zhao, Xin Li, Wenbo Chen, Hans Ågren, Qing Zhang, Liangliang Zhu
CH-π interaction assisted alignment of organic conjugated systems has played an important role to regulate molecular electronic and photophysical properties, whereas harnessing such a smart non-covalent interaction into the tuning of unimolecular complex emissive bands covering a wide spectral region remains a challenging research topic. Since the tuning for visible and near-infrared emissive properties in a single π-functional platform relates to its multi-color luminescent behaviors and potential superior application in analysis, imaging and sensing, we here report that a proportional control of the singlet and triplet emissions that cover visible and near-infrared spectral region, respectively, can be straightforwardly achieved by CH-π interaction assisted self-assembly at the unimolecular level...
January 11, 2017: ACS Applied Materials & Interfaces
Hanying Zhao, Yuanyuan Ju, Cheng Xing, Dongxia Wu, Yunfang Wu, Lianyong Wang
In this research, covalently connected polymer-protein nanostructures were fabricated by reactive self-assembly approach. PtBMA-co-PPDSMA was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. Covalently connected nanostructures (CCNs) with hydrophobic polymer cores and hydrophilic protein coronae were prepared by adding PtBMA-co-PPDSMA/DMF solutions into bovine serum albumin (BSA) aqueous solutions. The thiol-disulfide exchange reaction between the pyridyl disulfide groups on the polymer chains and the thiol groups on the protein molecules plays a key role in the fabrication of CCNs...
January 10, 2017: Chemistry: a European Journal
Yahong Li, Haifeng Zhang, Rui Liu, Jin Zhang, Wei Liu, Yaping Dong
Five hexanuclear lanthanide clusters of compositions [Ln6(μ4-O)2(HCOO)2L4(HL')2(DMF)2] (Ln = Dy (1), Er (2), Ho (3), Tb (4), Gd (5); H2L = 2-((2-(hydroxymethyl)phenylimino)methyl)-6-methoxy-phenol; H3L' = 3-((2-(hydroxymethyl)phenylimino)methyl) benzene-1,2-diol, and H3L' was derived in situ from the H2L ligand) have been prepared under solvothermal conditions. The [Ln6] cores of 1-5 possess an unprecedented motif, namely, two tetrahedron Ln4 units sharing an edge and two vertices. The six LnIII ions of 1-5 are connected via two μ4-O anions...
January 9, 2017: Chemistry, An Asian Journal
Nathaniel Edward Bennett Saidu, Gaëlle Noé, Olivier Cerles, Luc Cabel, Niloufar Kavian-Tessler, Sandrine Chouzenoux, Mathilde Bahuaud, Christiane Chéreau, Carole Nicco, Karen Leroy, Bruno Borghese, Francois Goldwasser, Frédéric Batteux, Jerome Alexandre
The transcription factor NRF2 (NFE2L2), regulates important antioxidant and cytoprotective genes. It enhances cancer cell proliferation and promotes chemoresistance in several cancers. Dimethyl fumarate (DMF) is known to promote NRF2 activity in non-cancer models. We combined in vitro and in vivo methods to examine the effect of DMF on cancer cell death and the activation of the NRF2 antioxidant pathway. We demonstrated that at lower concentrations (< 25 μM), DMF has a cytoprotective role through activation of the NRF2 antioxidant pathway...
January 9, 2017: Molecular Cancer Therapeutics
Jens Christoph Natterodt, Janak Sapkota, E Johan Foster, Christoph Weder
Cellulose nanocrystals (CNCs) are mechanically rigid, toxicologically benign, fiber-like nanoparticles. They can easily be extracted from renewable bio-sources and have attracted significant interest as reinforcing fillers in polymers. We here report the modification of CNCs with the 2-ureido-4[1H]pyrimidinone (UPy) motif as an adaptive compatibilizer, which permits the dispersion of UPy-modified CNCs in nonpolar as well as polar media. In toluene, the UPy motifs appear to form intra-CNC dimers, so that the particles are somewhat hydrophobized and well-dispersible in this nonpolar solvent...
January 9, 2017: Biomacromolecules
Dongdong Dong, Hui Deng, Chao Hu, Huaibing Song, Keke Qiao, Xiaokun Yang, Jian Zhang, Fensha Cai, Jiang Tang, Haisheng Song
To date, all the lead halide based full-inorganic or organic-inorganic hybrid perovskites have been synthesized from organic solvent, such as N,N-dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), by a solution method. Herein, water has been utilized as a 'green' solvent to develop an efficient synthetic route to grow various kinds of lead halide perovskite nanowires (NWs). By controlling the proportion of the hybrid cations, Csx(CH3NH3)1-xPbI3 perovskite NWs were successfully synthesized. Every Csx(CH3NH3)1-xPbI3 perovskite NW demonstrated single crystal characteristics with uniform stoichiometric element distribution...
January 9, 2017: Nanoscale
Neha Gupta, Divya Singhal, Ashok Kumar Singh, Neetu Singh, U P Singh
A colorimetric and fluorometric probe (E)-2-((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)hydrazinecarbothioamide based on thiosemicarbazide and julolidine moieties has been synthesised in pure crystalline form and characterized by (1)H NMR, UV-vis, elemental analysis and single crystal XRD. The probe functioned as multitarget ion sensor, detect biologically important metal ions Hg(2+) and Mn(2+) in dual channel mode. Meanwhile, in mixed solvent media DMF/H2O [8:2], probe displayed selectivity for Hg(2+) over other cations by the emission spectrum...
January 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Jianjun Cheng, Wenting Li, Guanghui Tan, Zhiqiang Wang, Shuying Li, Yingxue Jin
Photodynamic therapy (PDT) is entering the mainstream of the cancer treatments recently. Pyropheophorbide-a (Pa), as a degradation product of chlorophyll-a, has been shown to be a potent photosensitizer in photodynamic therapy. In this paper, we investigated the in vitro photodynamic therapy of 13(1)-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a (PHPa) against human HeLa cervical cancer cell line, together with ultraviolet-visible spectra, fluorescence emission spectra, stability in various solvents, and single oxygen quantum yield...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Erum Nosheen, Syed Mujtaba Shah, Zafar Iqbal
This article provides a facile one step synthesis of CdS (cadmium sulphide) and CdS/rGO (reduced graphene oxide CdS nanocomposites) using DMF (N, N-Dimethyl formamide) both as a solvent and a reducing agent for the reduction of grapheme oxide. XRD (X-ray diffraction), FESEM (Field emission scanning electron microscopy), EDX (Elemental dispersive X-ray analysis), TEM (Transmission electron microscopy), UV-Vis (UV-visible) and Raman spectroscopy have been employed for the characterization of prepared samples...
December 30, 2016: Journal of Photochemistry and Photobiology. B, Biology
Pierre Thuéry, Jack Harrowfield
Racemic and enantiopure (1R,2R) forms of trans-1,2-cyclohexanedicarboxylic acid (H2chdc and R-H2chdc, respectively) have been used in the synthesis of a series of 13 uranyl ion complexes, all obtained under solvo-hydrothermal conditions and in the presence of additional metal cations and/or N-donor ligands. While the homometallic complex [UO2(R-chdc)] (1) was only obtained with the enantiopure ligand, complexes [UO2(chdc)(THF)] (2), [UO2(chdc)(DMF)] (3), and [UO2(chdc)(NMP)] (4), with a coordinated solvent molecule, were obtained from the racemic form only; all crystallize as two-dimensional (2D) assemblies...
January 6, 2017: Inorganic Chemistry
Huiying Niu, Lijun Lu, Renyi Shi, Chien-Wei Chiang, Aiwen Lei
Recently, utilizing CO2 as a methylation reagent to construct functional chemicals has attracted significant attention. However, the conversion of CO2 is still a challenge due to its inherent inertness. In this study, we have developed a catalyst-free N-methylation of amines to prepare numerous methylamines using CO2 as a methyl source. By utilizing 2 eq. PhSiH3 as the reductant, amines could undergo N-methylation under 1 atm of CO2 in DMF at 90 °C. Aliphatic and aromatic amines were compatible, generating the desired products in up to 95% yield...
January 5, 2017: Chemical Communications: Chem Comm
Fei Wu, Lei Su, Ping Yu, Lanqun Mao
Improving bioelectrocatalytic current response of redox enzymes on electrodes has been a focus in the development of enzymatic biosensors and biofuel cells. Herein a mediatorless electroreduction of oxygen is effectively improved in terms of a remarkable enhancement by ca. 600% in maximum reductive current by simply adding 20% ethanol into laccase solution during its immobilization onto single-walled carbon nanotubes (SWCNTs). Conformation analysis by circular dichroism and attenuated total reflectance infrared spectroscopy demonstrate promoted laccase-SWCNTs contact by ethanol, thus leading to favorable enzyme orientation on SWCNTs...
January 18, 2017: Journal of the American Chemical Society
Poonam Singh, Joseph H Rheinhardt, Jarred Z Olson, Pilarisetty Tarakeshwar, Vladimiro Mujica, Daniel A Buttry
We describe a new electrochemical cycle that enables capture and release of carbon dioxide. The capture agent is benzylthiolate (RS-), generated electrochemically by reduction of benzyldisulfide (RSSR). Reaction of RS- with CO2 produces a terminal, sulfur-bound monothiocarbonate, RSCO2-, which acts as the CO2 carrier species, much the same as a carbamate serves as the CO2 carrier for amine-based capture strategies. Oxidation of the thiocarbonate releases CO2 and regenerates RSSR. The newly reported S-benzylthiocarbonate (IUPAC name benzylsulfanylformate) is characterized by 1H and 13C NMR, FTIR and electrochemical analysis...
January 4, 2017: Journal of the American Chemical Society
Napapach Chuaychu-Noo, Pachara Thananurak, Vibantita Chankitisakul, Thevin Vongpralub
Little is known about the effects of Cholesterol-Loaded Cyclodextrin (CLC) on post-thaw semen quality in chicken. The aim of the present study is to investigate the efficacy of CLC levels (0, 1, 2 and 3 mg/mL Schramm diluent) on post-thawed semen quality and fertility in two breeds of chicken Pradu Hang Dum (native chicken) and Rhode Island Red. Semen samples of each breed were pooled, divided into 4 aliquots and diluted with Schramm diluents, cooled to 5 °C when DMF was added (6% of final volume). Semen straws were subjected to cryopreservation using the liquid nitrogen vapor method...
December 31, 2016: Cryobiology
Kei Oikawa, Satoshi Itoh, Hiroki Yano, Hideya Kawasaki, Yasushi Obora
We report methylations of alcohols and anilines catalyzed by DMF-stabilized Ir nanoclusters using methanol as the C1 source. The DMF-stabilized Ir nanoclusters were prepared in one step and have diameters of 1-1.5 nm. They react in a borrowing-hydrogen reaction and are efficient methylation catalysts (TON up to 310 000).
January 3, 2017: Chemical Communications: Chem Comm
Suzanne M Adam, Isaac Garcia-Bosch, Andrew W Schaefer, Savita K Sharma, Maxime A Siegler, Edward I Solomon, Kenneth D Karlin
The 4H(+)/4e(-) reduction of O2 to water, a key fuel-cell reaction also carried out in biology by oxidase enzymes, includes the critical O-O bond reductive cleavage step. Mechanistic investigations on active-site model compounds, which are synthesized by rational design to incorporate systematic variations, can focus on and resolve answers to fundamental questions, including protonation and/or H-bonding aspects, which accompany electron transfer. Here, we describe the nature and comparative reactivity of two low-spin heme-peroxo-Cu complexes, LS-4DCHIm, [(DCHIm)F8Fe(III)-(O2(2-))-Cu(II)(DCHIm)4](+), and LS-3DCHIm, [(DCHIm)F8Fe(III)-(O2(2-))-Cu(II)(DCHIm)3](+) (F8 = tetrakis(2,6-difluorophenyl)-porphyrinate; DCHIm = 1,5-dicyclohexylimidazole), toward different proton (4-nitrophenol and [DMF·H(+)](CF3SO3(-))) (DMF = dimethyl-formamide) or electron (decamethylferrocene (Fc*)) sources...
December 28, 2016: Journal of the American Chemical Society
Hongwei Wu, Yunyun Zhou, Liyuan Yin, Cheng Hang, Xin Li, Hans Ågren, Tao Yi, Qing Zhang, Liangliang Zhu
In nanoscience, chirality has shown a significant ability to tune materials' electronic properties, whereas imposing macrochirality into the regulation of singlet-triplet features of organic optoelectronics remains a challenging research topic. Since the tuning for singlet and triplet excited-state properties in a single π-functional molecule connects to its multicolor luminescent application and potential improvement of internal quantum efficiency, we here report that supramolecular chirality can be employed to toggle the singlet and triplet emissions in a well-designed asterisk-shaped molecule...
January 18, 2017: Journal of the American Chemical Society
Kavita Plaka, Khaiwal Ravindra, Suman Mor, Krishan Gauba
The aim of the study was to assess the prevalence of dental fluorosis, dental caries, and associated risk factors in the school children of district Fatehgarh Sahib, Punjab, India, using a cross-sectional study design. Oral health status of children aged between 8 and 15 years was assessed using World Health Organization (WHO) 2013 criteria. Dental fluorosis was assessed using Dean's index, and dental caries were recorded using decayed, missing, filled/decayed, extracted, filled (DMF/def) indices. Four hundred school children were examined, of which 207 were in the 8-11-year-old group and 193 were in the 12-15-year-old group...
January 2017: Environmental Monitoring and Assessment
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