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https://www.readbyqxmd.com/read/28328179/effect-of-delayed-release-dimethyl-fumarate-on-no-evidence-of-disease-activity-in-relapsing-remitting-multiple-sclerosis-integrated-analysis-of-the-phase-iii-define-and-confirm-studies
#1
E Havrdova, G Giovannoni, R Gold, R J Fox, L Kappos, J Theodore Phillips, M Okwuokenye, J L Marantz
BACKGROUND AND PURPOSE: Significant effects on clinical/neuroradiological disease activity have been reported in patients with relapsing-remitting multiple sclerosis treated with delayed-release dimethyl fumarate (DMF) in phase III DEFINE/CONFIRM trials. We conducted a post hoc analysis of integrated data from DEFINE/CONFIRM to evaluate the effect of DMF on achieving no evidence of disease activity (NEDA) in patients with relapsing-remitting multiple sclerosis. METHODS: The analysis included patients randomized to DMF 240 mg twice daily, placebo or glatiramer acetate (CONFIRM only) for ≤2 years...
March 22, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28327767/regioselective-sn2-reactions-for-rapid-syntheses-of-azido-inositols-by-one-pot-sequence-specific-nucleophilysis
#2
Arthi Ravi, Syed Zahid Hassan, Ajithkumar N Vanikrishna, Kana M Sureshan
Triflates of myo-inositol undergo facile solvolysis in DMSO and DMF yielding SN2 products substituted with O-nucleophiles; DMF showed slower kinetics. Axial O-triflate undergoes faster substitution than equatorial O-triflate. By exploiting this difference in kinetics, solvent-tuning and sequence-controlled nucleophilysis, rapid synthesis of three azido-inositols of myo-configuration from myo-inositol itself has been achieved.
March 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28322482/progressive-multifocal-leukoencephalopathy-associated-with-fumaric-acid-esters-treatment-in-psoriasis-patients
#3
Deepak M W Balak, Enes Hajdarbegovic, Wichor M Bramer, Martino H A Neumann, H Bing Thio
BACKGROUND: Fumaric acid esters (FAEs) are a systemic treatment for psoriasis considered to have a favorable long-term safety profile without an increased risk for immunosuppression. However, progressive multifocal leukoencephalopathy (PML), a rare, opportunistic viral infection of the central nervous system, has been linked anecdotally to FAE treatment. OBJECTIVE: to assess clinical features and outcomes of FAE-associated PML cases. METHODS: Systematic literature search in multiple databases up to February, 25(th) 2016 for reports of PML in psoriasis patients treated with FAEs...
March 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28321050/alteration-of-gut-microbial-community-after-n-n-dimethylformamide-exposure
#4
Man Zhang, Min Zheng, Zhijun Wu, Mingyue Guan, Shuai Liu, Wenjin Zhao, Juan Cheng
N,N-Dimethylformamide (DMF), a solvent commonly used in factories, can induce liver toxicities, including hepatitis, fibrosis, cirrhosis and hepatoma. It is well known that the gut microbial community plays a role in the metabolism of many toxic substance and in liver regeneration. However, the effect of DMF on rat gut microbial community is poorly understood. The gut microbiotas in control rats and rats exposed to DMF were characterized by high-throughput sequencing of the bacterial 16S rRNA gene. The levels of biochemical parameters in the serum of rats, including cholesterol, bile acid, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were evaluated...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28318248/ultrastable-1d-europium-complex-for-simultaneous-and-quantitative-sensing-of-cr-iii-and-cr-vi-ions-in-aqueous-solution-with-high-selectivity-and-sensitivity
#5
Jingjuan Liu, Guanfeng Ji, Jiannan Xiao, Zhiliang Liu
A unique metal-organic complex (MOC) with formula [Eu2(tpbpc)4·CO3·4H2O]·DMF·solvent (Htpbpc = 4'-[4,2';6',4″]-terpyridin-4'-yl-biphenyl-4-carboxylic acid) has been successfully constructed under solvothermal conditions. The Eu complex, as proved by structural analysis, exhibits a fascinating 1D linear-type chain structure which is further extended to a 3D H-bonded supramolecular framework. The luminescent investigations confirm that the emission behavior of the Eu complex possesses excellent water stability and pH stability, and it is the first example of a MOC-based fluorescent probe with high selectivity, high sensitivity, and low detection limit, targeting Cr(III) and Cr(VI) (CrO4(2-)/Cr2O7(2-)) ions in aqueous solution...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28318245/dinuclear-rhenium-complex-with-a-proton-responsive-ligand-as-a-redox-catalyst-for-the-electrochemical-co2-reduction
#6
Alexander Wilting, Thorsten Stolper, Ricardo A Mata, Inke Siewert
Herein, we present the reduction chemistry of a dinuclear α-diimine rhenium complex, 1, [Re2(L)(CO)6Cl2], with a proton responsive ligand and its application as a catalyst in the electrochemical CO2 reduction reaction (L = 4-tert-butyl-2,6-bis(6-(1H-imidazol-2-yl)-pyridin-2-yl)phenol). The complex has a phenol group in close proximity to the active center, which may act as a proton relay during catalysis, and pyridine-NH-imidazole units as α-diimine donors. The complex is an active catalyst for the electrochemical CO2 reduction reaction...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28294545/oral-health-related-quality-of-life-depending-on-oral-health-and-specific-factors-in-patients-after-lung-transplantation
#7
Gerhard Schmalz, Horst Wendorff, Anna Marcinkowski, Gerhard Weinreich, Helmut Teschler, Rainer Haak, Urte Sommerwerck, Dirk Ziebolz
INTRODUCTION: Patients after lung transplantation (LuTx) were found to present oral health deficiencies. The investigation of potentially underlying or influencing factors appears to be of clinical relevance. OBJECTIVES: Aim of this study was to evaluate the oral health related quality of life (OHRQoL) in a group of patients after LuTx and compare this to a healthy control group (HC). Furthermore, the influence of dental and periodontal condition, as well as specific factors like immunosuppression, time after LuTx and causal underlying disease should be investigated...
March 13, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28291792/synthesis-and-characterization-of-porous-silicon-as-hydroxyapatite-host-matrix-of-biomedical-applications
#8
A Dussan, S D Bertel, S F Melo, F Mesa
In this work, porous-silicon samples were prepared by electrochemical etching on p-type (B-doped) Silicon (Si) wafers. Hydrofluoric acid (HF)-ethanol (C2H5OH) [HF:Et] and Hydrofluoric acid (HF)-dimethylformamide (DMF-C3H7NO) [HF:DMF] solution concentrations were varied between [1:2]-[1:3] and [1:7]-[1:9], respectively. Effects of synthesis parameters, like current density, solution concentrations, reaction time, on morphological properties were studied by scanning electron microscopy (SEM) and atomic force microscopy (AFM) measurements...
2017: PloS One
https://www.readbyqxmd.com/read/28285876/one-pot-synthesis-of-a-new-2-substituted-1-2-3-triazole-1-oxide-derivative-from-dipyridyl-ketone-and-isonitrosoacetophenone-hydrazone-nickel-ii-complex-dna-binding-and-cleavage-properties
#9
Ramazan Gup, Oktay Erer, Nefise Dilek
An efficient and simple one-pot synthesis of a new 1,2,3-triazole-1-oxide via reaction between isonitrosoacetophenone hydrazone and dipyridyl ketone in the EtOH/AcOH at room temperature has been developed smoothly in high yield. The reaction proceeds via metal salt free, in-situ formation of asymmetric azine followed by cyclization to provide 1,2,3-triazole 1-oxide compound. It has been structurally characterized. The 1:1 ratio reaction of the 1,2,3-triazole 1-oxide ligand with nickel(II) chloride gives the mononuclear complex [Ni(L)(DMF)Cl2], hexa-coordinated within an octahedral geometry...
March 3, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28283486/systematic-literature-review-and-network-meta-analysis-in-highly-active-relapsing-remitting-multiple-sclerosis-and-rapidly-evolving-severe-multiple-sclerosis
#10
Eline Huisman, Katerina Papadimitropoulou, James Jarrett, Matthew Bending, Zoe Firth, Felicity Allen, Nick Adlard
OBJECTIVE: Multiple sclerosis (MS) is a chronic, neurodegenerative autoimmune disorder affecting the central nervous system. Relapsing-remitting MS (RRMS) is the most common clinical form of MS and affects ∼85% of cases at onset. Highly active (HA) and rapidly evolving severe (RES) RRMS are 2 forms of RRMS amenable to disease-modifying therapies (DMT). This study explored the efficacy of fingolimod relative to other DMTs for the treatment of HA and RES RRMS. METHODS: A systematic literature review (SLR) was conducted to identify published randomised controlled trials in HA and RES RRMS...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28277679/electrochemical-reduction-of-co2-catalyzed-by-re-pyridine-oxazoline-co-3cl-complexes
#11
John K Nganga, Christian R Samanamu, Joseph M Tanski, Carlos Pacheco, Cesar Saucedo, Victor S Batista, Kyle A Grice, Mehmed Z Ertem, Alfredo M Angeles-Boza
A series of rhenium tricarbonyl complexes coordinated by asymmetric diimine ligands containing a pyridine moiety bound to an oxazoline ring were synthesized, structurally and electrochemically characterized, and screened for CO2 reduction ability. The reported complexes are of the type Re(N-N)(CO)3Cl, with N-N = 2-(pyridin-2-yl)-4,5-dihydrooxazole (1), 5-methyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (2), and 5-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole (3). The electrocatalytic reduction of CO2 by these complexes was observed in a variety of solvents and proceeds more quickly in acetonitrile than in dimethylformamide (DMF) and dimethyl sulfoxide (DMSO)...
March 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28272376/a-palladium-catalyst-system-for-the-efficient-cross-coupling-reaction-of-aryl-bromides-and-chlorides-with-phenylboronic-acid-synthesis-and-biological-activity-evaluation
#12
Boubakri Lamia, Ahlem Chakchouk-Mtibaa, Bilel Hallouma, Lamjed Mansour, Lotfi Mellouli, Ismail Özdemir, Sedat Yaşar, Naceur Hamdi
New benzimidazolium salts 1a-c and their palladium bis-N-heterocyclic carbene complexes 2a-c and palladium PEPPSI-type complexes 3a-c were designed, synthesized and structurally characterized by NMR (1H and 13C), IR, DART-TOF mass spectrometry and elemental analysis. Then these complexes 2-3 were employed in the Suzuki-Miyaura cross-coupling reaction of substituted arenes with phenylboronic acid under mild conditions in toluene and DMF/H2O (1/1) to afford functionalized biaryl derivatives in good to excellent yields...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28267511/enhancing-cellulose-dissolution-in-ionic-liquid-by-solid-acid-addition
#13
Yahui Meng, Zhiqiang Pang, Cuihua Dong
It's challenging to dissolve natural cellulose in most solvents due to its highly ordered crystalline structure. In this paper, we developed an efficient cellulose dissolution system which incorporates solid acid (SA) with 1-butyl-3-methylimidizolium chloride (BmimCl). The results showed that addition of solid acid both Amberlyst(®) 15 and CsxH3-xPW12O40 could significantly enhance cellulose dissolution in BmimCl, which attributed to the synergistic action of free hydrogen proton from SA and chloride anion in BmimCl on hydroxyl groups of cellulose, and DMF as co-solvent also could facilitate cellulose dissolution in SA/BmimCl...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28260421/successful-pregnancy-after-natalizumab-associated-progressive-multifocal-leukoencephalopathy-in-a-patient-with-multiple-sclerosis
#14
Kalliopi Pitarokoili, Kerstin Hellwig, Carsten Lukas, Ralf Gold
We report the case of a post-progressive multifocal leukoencephalopathy (PML), multiple sclerosis (MS) patient with an uncomplicated pregnancy and delivery. A 28-year-old woman on natalizumab (total of 49 infusions) was diagnosed with PML due to typical magnetic resonance imaging (MRI) and clinical presentation. John Cunningham virus (JCV) was detected in the cerebrospinal fluid (CSF) during the immune reconstitution inflammatory syndrome (IRIS). Nine months after PML onset, JCV negativity in the CSF was observed...
March 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28258191/dimethyl-fumarate-selectively-reduces-memory-t-cells-and-shifts-the-balance-between-th1-th17-and-th2-in-multiple-sclerosis-patients
#15
Qi Wu, Qin Wang, Guangmei Mao, Catherine A Dowling, Steven K Lundy, Yang Mao-Draayer
Dimethyl fumarate (DMF; trade name Tecfidera) is an oral formulation of the fumaric acid ester that is Food and Drug Administration approved for treatment of relapsing-remitting multiple sclerosis. To better understand the therapeutic effects of Tecfidera and its rare side effect of progressive multifocal leukoencephalopathy, we conducted cross-sectional and longitudinal studies by immunophenotyping cells from peripheral blood (particularly T lymphocytes) derived from untreated and 4-6 and 18-26 mo Tecfidera-treated stable relapsing-remitting multiple sclerosis patients using multiparametric flow cytometry...
March 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28254330/selective-colorimetric-and-fluorescence-turn-on-sensor-for-ag-and-in-situ-sensing-of-cn-off-on-off-via-displacement-approach
#16
Nirma Maurya, Shubhrajyotsna Bhardwaj, Ashok Kumar Singh
In this contemporary work we designed and synthesized a simple tetra dentate Schiff base, which displays colorimetric and fluorescence "turn on" sensing behavior towards Ag(+) in aqueous DMF (50%) solution. Benesi Hildebrand-plot reveals 1:2 binding mode between probe and Ag(+) with limit of detection down to 1.12μM. Cyclic voltammograms exhibits high anodic shift with Ag(+) due to the charge transfer from ligand to metal ion. The binding mode was proved by NMR titrations, FE-SEM elemental analysis & advance DFT calculation...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28252608/-clinical-guidelines-for-the-use-of-dimethyl-fumarate-in-relapsing-remitting-multiple-sclerosis
#17
V M Alifirova, A N Boiko, Ya V Vlasov, M V Davydovskaya, M N Zakharova, N A Malkova, E V Popova, S A Sivertseva, N N Spirin, N V Khachanova, Т Е Shmidt
Multiple sclerosis is a chronic demyelinating and neurodegenerative disease of the central nervous system, in which autoimmune inflammation and oxidative stress play essential pathogenetic roles. Activation and infiltration of immune cells in brain tissues, lipid peroxidation products, mitochondrial dysfunction, defective antioxidant protection, and many other pathological factors result in demyelination, axonal injury and death, and apoptosis of oligodendrocytes and neurons, all of which causes constant progression of the disease...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28250669/xylitol-in-preventing-dental-caries-a-systematic-review-and-meta-analyses
#18
REVIEW
Chandrashekar Janakiram, C V Deepan Kumar, Joe Joseph
Xylitol is a sugar alcohol having the properties that reduce levels of mutans streptococci (MS) in the plaque and saliva. To assess the role of xylitol in preventing dental caries. Systematic review and meta-analysis developed by Cochrane cooperation were adapted. Electronic search was carried out in PubMed through the period up to 2014. Included clinical studies were done on (1) humans (2) participants include both individuals and as pairs (mother-child) (3) participants using orthodontic appliances (4) xylitol dispensed in any form (5) compare the effect of xylitol on dental caries and on other phenotype that determines the preventive effect on dental caries, such as decayed, missing, and filled (DMF/dmf) and salivary or plaque MS level...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28247911/opposing-effects-of-nrf2-and-nrf2-activating-compounds-on-the-nlrp3-inflammasome-independent-of-nrf2-mediated-gene-expression
#19
Martha Garstkiewicz, Gerhard E Strittmatter, Serena Grossi, Jennifer Sand, Gabriele Fenini, Sabine Werner, Lars E French, Hans-Dietmar Beer
The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress-induced protein complexes. They are critically involved in acute and chronic inflammation through caspase-1-mediated activation of pro-inflammatory cytokines. Here, we demonstrate that Nrf2 is as a positive regulator of the NLRP3 inflammasome. In contrast, Nrf2-activating compounds, including the anti-inflammatory drug dimethyl fumarate (DMF), inhibit inflammasome activation...
March 1, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28247882/anion-templated-nanosized-silver-clusters-protected-by-mixed-thiolate-and-diphosphine
#20
Xiao-Yu Li, Zhi Wang, Hai-Feng Su, Sheng Feng, Mohamedally Kurmoo, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
S(2-), MoO4(2-), and Mo6O22(8-) were successfully employed as templates in the formation of six high-symmetry polynuclear silver clusters as exemplified in the single-crystal X-ray structures of [S@Ag18((t)BuC6H4S)16(dppp)4]·DMF·5CH3CN·3CH3OH (1), [MoO4@Ag24(MeC6H4S)12(dppm)6(MoO4)4]·2BF4·C2H5NO (2), [MoO4@Ag24(MeC6H4S)12(dppm)6(MoO4)4]·2CF3SO3 (3), [MoO4@Ag24(MeC6H4S)12(dppf)6(MoO4)4]·2CF3SO3 (4), [MoO4@Ag24(MeC6H4S)12(dppb)6(MoO4)4]·2CF3SO3 (5) and [Mo6O22@Ag46((t)BuC6H4S)32(dppm)4(CH3CN)8]·6CF3SO3 (6) (dppp = 1,3-bis(diphenylphosphino)propane, dppm = bis(diphenylphosphino)methane, dppf = 1,1'-bis(diphenylphosphino)ferrocene and dppb = 1,4-bis(diphenylphosphino)butane)...
March 1, 2017: Nanoscale
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