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https://www.readbyqxmd.com/read/27933240/synthesis-of-2-tetrafluoropyridyl-4-5-disubstituted-1-2-3-triazoles
#1
Khalil Beyki, Malek Taher Maghsoodlou, Reza Heydari
ABSTRACT: By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivity of the compounds are confirmed by (19)F-NMR and other spectroscopy. GRAPHICAL ABSTRACT: HASH(0x59e3290)
2016: SpringerPlus
https://www.readbyqxmd.com/read/27931163/preparation-characterization-and-in-vitro-anticoagulant-activity-of-corn-stover-xylan-sulfates
#2
He-Li Cheng, Hao Liu, Qing-Hua Feng, Yi-Min Xie, Huai-Yu Zhan
A new anticoagulant agent was prepared by introducing sulfate groups into corn stover xylan through homogeneous reactions. Three organic solvents, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and formamide (FA), were adopted as reaction media, with the assistance of LiCl. Structural characterization by FT-IR and (13)CNMR showed that xylan sulfate (XS) could be successfully synthesized with SO3∙Pyridine (SO3∙Py) complexes sulfation reagent in the three media. The effect of sulfation temperature, sulfation time, media type and molar ratio of -SO3/-OH on the degree of substitution (DS) and degree of the polymerization (DP) were studied...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27929587/highly-efficient-electrochemiluminescence-based-on-4-amino-1-2-4-triazole-schiff-base-two-dimensional-zn-cd-coordination-polymers
#3
Shu-Hua Zhang, Ji-Ming Wang, Hai-Yang Zhang, Yi-Peng Fan, Yu Xiao
Four coordination polymers, formulated as [Zn(L(1))2]n (1), [Cd(L(1))2]n (2), [Zn(L(2))2]n (3) and [Cd(L(2))2]n (4) (HL1 is (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-4,6-dibromophenol; HL2 is (E)-2-(((4H-1,2,4-triazol-4-yl)imino)methyl)-4,6-dichlorophenol) have been synthesized through vial reactions. The four compounds were structurally characterized by single crystal X-ray diffraction, elemental analysis, PXRD, and fluorescence spectroscopy. For 1-4, a detailed analysis of Hirshfeld surfaces and fingerprint plots facilitates a comparison of intermolecular interactions, which are crucial in building different supramolecular architectures...
December 8, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27924976/simple-and-high-yield-access-to-octafunctional-azido-amine-and-urea-group-bearing-cubic-spherosilicates
#4
Sandra Schäfer, Guido Kickelbick
Spherosilicates and polyhedral oligomeric silsesquioxanes represent unique well-defined rigid building blocks for molecular and hybrid materials. Drawbacks in their synthesis are often low yields and the restricted presence of functional groups either based on incomplete transformation of all corners or the reactivity of the functional groups. Particularly amine-functionalization reveals some synthetic challenges. In this study we report the synthesis of a new class of octafunctionalized hydrogen bond forming spherosilicates via a facile route based on octabromo alkyl functionalized cubic spherosilicates...
December 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27923733/cognitive-control-of-vocalizations-in-the-primate-ventrolateral-dorsomedial-frontal-vlf-dmf-brain-network
#5
REVIEW
Loh Kep Kee, Petrides Michael, Hopkins D William, Procyk Emmanuel, Amiez Céline
This review centers on the neural mechanisms underlying the primate cognitive control of vocalizations i.e. the capacity to regulate vocal productions in a goal-directed manner. In both human and non-human primates (NHPs), two main frontal brain regions are associated with top-down vocal control: a ventrolateral frontal region (VLF), comprising the ventrolateral prefrontal cortex and ventral premotor region; and a dorsomedial frontal region (DMF), comprising the mid-cingulate cortex, pre-supplementary and supplementary motor areas...
December 3, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27923138/metallogel-templated-synthesis-and-stabilization-of-silver-particles-and-its-application-in-catalytic-reduction-of-nitro-arene
#6
Mukesh Sharma, Plaban Jyoti Sarma, Manash Jyoti Goswami, Kusum K Bania
Metallogel of iron-carboxylates was obtained from trans-1,2-cyclohexanedicarboxylic acid in dimethylformamide (DMF) at basic condition. Spectroscopic and SEM morphology study of the iron-metallogel revealed that the iron complex with dicarboxylic acid was linked together via carboxylates and led to a supramolecular helical like architecture. The synthesized metallogel served as an excellent template for in-situ reduction of silver ion to silver particles micro to nano scale range. Variation of AgNO3 concentration shepherd to change the morphology of the Ag-particles...
November 20, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27920919/crystal-structure-of-di-methyl-formamidium-bis-tri-fluoro-methane-sulfon-yl-amide-an-ionic-liquid
#7
Allan Jay P Cardenas, Molly O'Hagan
At 100 K, the title mol-ecular salt, C3H8NO(+)·C2F6NO4S2(-), has ortho-rhom-bic (P212121) symmetry; the amino H atom of bis-(tri-fluoro-methane-sulfon-yl)amine (HNTf2) was transferred to the basic O atom of di-methyl-formamide (DMF) when the ionic liquid components were mixed. The structure displays an O-H⋯N hydrogen bond, which links the cation to the anion, which is reinforced by a non-conventional C-H⋯O inter-action, generating an R2(2)(7) loop. A further very weak C-H⋯O inter-action generates an [001] chain...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27919497/comparative-efficacy-and-discontinuation-of-dimethyl-fumarate-and-fingolimod-in-clinical-practice-at-12-month-follow-up
#8
Carrie M Hersh, Thomas E Love, Samuel Cohn, Claire Hara-Cleaver, Robert A Bermel, Robert J Fox, Jeffrey A Cohen, Daniel Ontaneda
BACKGROUND: Dimethyl fumarate (DMF) and fingolimod (FTY) are approved oral disease modifying therapies (DMT) for relapsing multiple sclerosis (MS). Phase 3 trials established these agents as effective and generally well tolerated, though comparative efficacy and discontinuation remain unknown. OBJECTIVE: To assess real-world efficacy and discontinuation of DMF and FTY over 12 months in patients with MS. METHODS: We identified 458 DMF-treated and 317 FTY-treated patients in a large academic MS center...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919491/comparing-outcomes-from-clinical-studies-of-oral-disease-modifying-therapies-dimethyl-fumarate-fingolimod-and-teriflunomide-in-relapsing-ms-assessing-absolute-differences-using-a-number-needed-to-treat-analysis
#9
Mark S Freedman, Xavier Montalban, Aaron E Miller, Catherine Dive-Pouletty, Steven Hass, Karthinathan Thangavelu, Thomas P Leist
Dimethyl fumarate (DMF), fingolimod, and teriflunomide are oral disease-modifying therapies (DMTs) indicated for the treatment of relapsing-remitting multiple sclerosis. Despite well-established limitations of cross-trial comparisons, DMTs are still frequently compared in terms of relative reductions in specific endpoints, most commonly annualized relapse rate. Consideration of absolute risk reduction and number needed to treat (NNT) provides an alternative approach to assess the magnitude of treatment effect and can provide valuable additional information on therapeutic gain...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27917419/polyurethanes-with-aggregation-enhanced-emission-characteristics-preparation-and-properties
#10
Kun Wang, Jiping Yang, Chen Gong, Hao Lu
An amino-terminated poly(propylene glycol)-modified tetraaryl-buta-1,3-diene derivative (TABDAA) was introduced to synthesize polyurethanes with different ratios of soft/hard segments. A mixture of TABDAA and poly(tetrahydrofuran) 1000 as the soft segments was reacted with 4,4-diphenylmethane diisocyanate and 1,4-butanediol as the hard segments in molar ratios of 1 : 2 : 1, 2 : 3 : 1, and 3 : 4 : 1 to give the desired polyurethanes named TMPU-211, TMPU-321 and TMPU-431, respectively...
December 5, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27914607/ultra-high-performance-size-exclusion-chromatography-in-polar-solvents
#11
Gertjan Vancoillie, Maarten Vergaelen, Richard Hoogenboom
Size-exclusion chromatography (SEC) is amongst the most widely used polymer characterization methods in both academic and industrial polymer research allowing the determination of molecular weight and distribution parameters, i.e. the dispersity (Ɖ), of unknown polymers. The many advantages, including accuracy, reproducibility and low sample consumption, have contributed to the worldwide success of this analytical technique. The current generation of SEC systems have a stationary phase mostly containing highly porous, styrene-divinylbenzene particles allowing for a size-based separation of various polymers in solution but limiting the flow rate and solvent compatibility...
November 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27911034/improved-li-storage-through-homogeneous-n-doping-within-highly-branched-tubular-graphitic-foam
#12
Jinyang Dong, Yanming Xue, Chao Zhang, Qunhong Weng, Pengcheng Dai, Yijun Yang, Min Zhou, Cuiling Li, Qiuhong Cui, Xiaohong Kang, Chengchun Tang, Yoshio Bando, Dmitri Golberg, Xi Wang
A novel carbon structure, highly branched homogeneous-N-doped graphitic (BNG) tubular foam, is designed via a novel N, N-dimethylformamide (DMF)-mediated chemical vapor deposition method. More structural defects are found at the branched portions as compared with the flat tube domains providing abundant active sites and spacious reservoirs for Li(+) storage. An individual BNG branch nanobattery is constructed and tested using in situ transmission electron microscopy and the lithiation process is directly visualized in real time...
December 2, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27910974/fine-tuning-terminal-solvent-ligands-to-rationally-enhance-the-energy-barrier-in-dinuclear-dysprosium-single-molecule-magnets
#13
Kun Zhang, Chen Yuan, Fu-Sheng Guo, Yi-Quan Zhang, Yao-Yu Wang
In search of simple approaches to rationally enhance the energy barriers in polynuclear dysprosium single-molecule magnets, a new system containing two structurally closely related dinuclear dysprosium complexes, namely [Dy2(L)2(DBM)2(DMF)2] (1) and [Dy2(L)2(DBM)2(DMA)2]·2DMA (2) (HDBM = dibenzoylmethane, H2L = 2-hydroxy-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide), is introduced and the structure-dependent magnetic properties are investigated. The two complexes display only slight variations in the coordination geometries of the Dy(iii) ion but display remarkably different magnetic behaviors...
December 2, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27906967/platinum-ii-iodido-complexes-of-7-azaindoles-with-significant-antiproliferative-effects-an-old-story-revisited-with-unexpected-outcomes
#14
Pavel Štarha, Ján Vančo, Zdeněk Trávníček, Jan Hošek, Jarmila Klusáková, Zdeněk Dvořák
A series of platinum(II) diiodido complexes containing 7-azaindole derivatives, having the general formula cis-[PtI2(naza)2] (1-8), has been prepared and thoroughly characterized, including X-ray structure analysis of cis-[PtI2(2Me4Claza)2]∙DMF (8∙DMF; 2Me4Claza = 2-methyl-4-chloro-7-azaindole). Complexes showed high in vitro cytotoxicity against nine human cancer cell lines (IC50 ranging from 0.4 to 12.8 μM), including the cisplatin-resistant ovarian cancer cell line (A2780R; IC50 = 1.0-3.5 μM). The results of in vivo testing, using the L1210 lymphocytic leukaemia model, at the equimolar doses of Pt with cisplatin (2 mg/kg) confirmed the activity of complex 8 comparable to cisplatin...
2016: PloS One
https://www.readbyqxmd.com/read/27896615/bioprospecting-hot-spring-metagenome-lipase-for-the-production-of-biodiesel
#15
Rajesh Kumar Sahoo, Mohit Kumar, Lala Behari Sukla, Enketeswara Subudhi
Screening of metagenomic library from Taptapani Hot Spring (Odisha) yielded a positive lipase clone (pUC-lip479). Sequence analysis showed an ORF (RK-lip479) of 416 amino acid residues which was overexpressed in Escherichia coli BL21 (DE3). Optimum pH and temperature of purified lipase RK-lip479 were 8.0 and 65 °C, respectively, and found to be stable over a pH range of 7.0-9.0 and temperatures 55-75 °C. RK-lip479 could hydrolyse a wide range of 4-nitrophenyl esters (4-nitrophenyoctanoate, 4-nitrophenyldodecanoate, 4-nitrophenylpalmitate, 4-nitrophenylmyristate and 4-nitrophenylstearate), and maximum activity was observed with 4-nitrophenyldodecanoate...
November 28, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27895261/photochemistry-of-framework-supported-m-diimine-co-3x-complexes-in-three-dimensional-lithium-carboxylate-metal-organic-frameworks-monitoring-the-effect-of-framework-cations
#16
Thomas J Reade, Thomas S Murphy, James A Calladine, Raphael Horvath, Ian P Clark, Gregory M Greetham, Michael Towrie, William Lewis, Michael W George, Neil R Champness
The structures and photochemical behaviour of two new metal-organic frameworks (MOFs) are reported. Reaction of Re(2,2'-bipy-5,5'-dicarboxylic acid)(CO)3Cl or Mn(2,2'-bipy-5,5'-dicarboxylic acid)(CO)3Br with LiCl or LiBr, respectively, produces single crystals of {Li2(DMF)2 [(2,2'-bipy-5,5'-dicarboxylate)Re(CO)3Cl]}n ( RELI: ) or {Li2(DMF)2[(2,2'-bipy-5,5'-dicarboxylate)Mn(CO)3Br]}n ( MNLI: ). The structures formed by the two MOFs comprise one-dimensional chains of carboxylate-bridged Li(I) cations that are cross-linked by units of Re(2,2'-bipy-5,5'-dicarboxylate)(CO)3Cl ( RELI: ) or Mn(2,2'-bipy-5,5'- dicarboxylate)(CO)3Br ( MNLI: )...
January 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27895256/a-sr2-metal-organic-framework-with-high-chemical-stability-synthesis-crystal-structure-and-photoluminescence-property
#17
Yan-Yuan Jia, Xiao-Ting Liu, Wen-He Wang, Li-Zhu Zhang, Ying-Hui Zhang, Xian-He Bu
Metal-organic frameworks (MOFs) are typically built by assembly of metal centres and organic linkers, and have emerged as promising crystalline materials in a variety of fields. However, the stability of MOFs is a key limitation for their practical applications. Herein, we report a novel Sr 2+: -MOF [Sr4(Tdada)2(H2O)3(DMF)2] (denoted as NKU- 105: , NKU = Nankai University; H4Tdada = 5,5'-((thiophene-2,5-dicar bonyl)bis(azanediyl))diisophthalic acid; DMF = N,N-dimethylformamide) featuring an open square channel of about 6 Å along the c-axis...
January 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27889959/fumaric-acid-esters-attenuate-secondary-degeneration-following-spinal-cord-injury
#18
Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Spinal cord injury (SCI) causes permanent changes in motor, sensory and autonomic functions. Unfortunately, there are not a stable cures and current treatments include surgical decompression, methylprednisolone and hemodynamic control that lead to modest function recovery. Fumaric acid esters (FAEs) were firstly used in the management of an immunological skin disorder, such as psoriasis. Because of their potent anti-inflammatory effects, they have been introduced in multiple sclerosis. Investigation shown not only anti-inflammatory, but also supposed neuroprotective mechanism of action...
November 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27889674/design-synthesis-characterization-and-cation-sensing-behavior-of-amino-naphthoquinone-receptor-selective-colorimetric-sensing-of-cu-ii-ion-in-nearly-aqueous-solution-with-mimicking-logic-gate-operation
#19
C Parthiban, Kuppanagounder P Elango
An amino-naphthoquione receptor (R1) has been rationally designed, synthesized and characterized using (1)H and (13)C NMR, LCMS and single crystal X-ray diffraction studies. The receptor exhibits an instantaneous colour change from yellow to blue selectively with Cu(II) ions in water-DMF (98:2% v/v) medium. The results of UV-Vis and fluorescence spectral studies indicates that the mechanism of sensing involves formation of a 1:1 complex between R1 and Cu(II) ion. The proposed mechanism has been confirmed through product analysis using FT-IR, UV-Vis, EPR and HRMS studies in addition to magnetic moment and elemental analysis measurements...
November 18, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27879637/temperature-triggered-switchable-helix-helix-inversion-of-poly-phenylacetylene-bearing-l-valine-ethyl-ester-pendants-and-its-chiral-recognition-ability
#20
Yanli Zhou, Chunhong Zhang, Yuan Qiu, Lijia Liu, Taotao Yang, Hongxing Dong, Toshifumi Satoh, Yoshio Okamoto
A phenylacetylene containing the l-valine ethyl ester pendant (PAA-Val) was synthesized and polymerized by an organorhodium catalyst (Rh(nbd)BPh₄) to produce the corresponding one-handed helical cis-poly(phenylacetylene) (PPAA-Val). PPAA-Val showed a unique temperature-triggered switchable helix-sense in chloroform, while it was not observed in highly polar solvents, such as N,N'-dimethylformamide (DMF). By heating the solution of PPAA-Val in chloroform, the sign of the CD absorption became reversed, but recovered after cooling the solution to room temperature...
November 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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