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Konstantin Huhn, Robert Lämmer, Hanna Zimmermann, Alexandra Lämmer, Anne Waschbisch, Kathrin Utz, René Markus Gieß, Friedemann Paul, Ralf A Linker, De-Hyung Lee
BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS typically affecting younger adults and resulting in neuro-axonal degeneration already at early stages of the disease. Less is known about the effects of a later disease onset (LOMS, onset >50years of age). Analysis of retinal layers by optical coherence tomography (OCT) is a non-invasive method to investigate retinal and neuro-axonal degeneration. We applied OCT to detect differences in retinal damage depending on a later disease manifestation...
November 15, 2016: Journal of the Neurological Sciences
Ryan L O'Hare Doig, Carole A Bartlett, Nicole M Smith, Stuart I Hodgetts, Sarah A Dunlop, Livia Hool, Melinda Fitzgerald
Combinations of Ca(2+) channel inhibitors have been proposed as an effective means to prevent excess Ca(2+) flux and death of neurons and glia following neurotrauma in vivo. However, it is not yet known if beneficial outcomes such as improved viability have been due to direct effects on intracellular Ca(2+) concentrations. Here, the effects of combinations of Lomerizine (Lom), YM872, memantine and/or oxATP to block voltage gated Ca(2+) channels, Ca(2+) permeable AMPA receptors, NMDA receptors and purinergic P2X7 receptors (P2X7R) respectively, on Ca(2+) concentration and viability of primary mixed cortical cultures exposed to hydrogen peroxide (H2O2) insult, were assessed...
October 7, 2016: Neuroscience
X Z Li, S H Choi, C G Yan, J S Shin, S B Smith
Supplementary dietary plant oils have the potential to alter milk fatty acid composition in ruminants as a result of changes in the amount and kind of fatty acid precursors. We hypothesized that linseed oil in combination with malate (a key propionate precursor in the rumen) would increase ∆9 unsaturated fatty acids and specific gene expression in somatic cells and mammary glands of lactating goats. Twelve lactating goats were used in a 3 × 3 Latin square design. Treatments included the basal diet (CON), the CON plus 4% linseed oil (LO), and the CON plus 4% linseed oil and 2% -malate (LOM)...
August 2016: Journal of Animal Science
Seong-In Lim, Hye-Young Jeoung, Byounghan Kim, Jae-Young Song, Jaejo Kim, Ha-Young Kim, In-Soo Cho, Gye-Hyeong Woo, Joong-Bok Lee, Dong-Jun An
The classical swine fever (CSF) vaccine, which is derived from the LOM strain of the CSF virus (CSFV), induces protective immunity against CSFV infection. However, several factors influence vaccine efficacy. Evidence suggests that infection by porcine reproductive and respiratory syndrome virus (PRRSV) and/or porcine circovirus 2 (PCV2) reduces the efficacy of several vaccines. Here, we examined the effect of PRRSV or PCV2 alone or co-infection by PRRSV/PCV2 on the potency of the LOM vaccine in pigs. Neither CSFV antibody levels nor the period during which CSFV antigens were detectable in LOM-vaccinated pigs were negatively affected by infection by PRRSV or PCV2...
September 25, 2016: Veterinary Microbiology
Xiao-hu Dai, Yong-gang Xue, Hua-jie Liu, Ling-ling Dai, Han Yan, Ning Li
Fluoroquinolone antibiotics (FQs), as the common pharmaceuticals and personal care products (PPCPs), are widespread in the environment. FQs contained in wastewater would be ultimately enriched in sludge, posing a potential threat to the consequent sludge utilization. To optimize the analytical method applicable to the determination of FQs in sludge, the authors selected ofloxacin (OFL), norfioxacin (NOR), ciprofloxacin (CIP) and lomefloxacin (LOM) as the target FQs, and established a method which was based on cell lysis, FQs extraction with triethylamine/methanol/water solution, Solid Phase Extraction (SPE) and HPLC-Fluorescence Detection (FLD) determination...
April 15, 2016: Huan Jing Ke Xue= Huanjing Kexue
Ankita Goyal, Manjunath Chaluvaiah Bhadravathi, Adarsh Kumar, Ridhi Narang, Ambika Gupta, Harneet Singh
INTRODUCTION: Sucrose is added as sweetening agent in liquid oral medication (LOM) to mask the acrid taste of medicines which may be potentially cariogenic. Many children under long term LOM therapy for treatment of epilepsy may be susceptible to dental caries. AIM: To assess and compare dental caries experience in children under long term liquid oral medication with those not under such medication among 2-12 years old children suffering from epilepsy. MATERIALS AND METHODS: A cross-sectional study was undertaken on a total of 84 children aged 2-12 years, who were suffering from epilepsy receiving liquid oral medication for more than 3 months were selected (study group) and for comparison 106 children of similar age group and disease but on other forms of medication were included as control group...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
William Grisham, Barbara Lom, Linda Lanyon, Raddy L Ramos
The scale of data being produced in neuroscience at present and in the future creates new and unheralded challenges, outstripping conventional ways of handling, considering, and analyzing data. As neuroinformatics enters into this big data era, a need for a highly trained and perhaps unique workforce is emerging. To determine the staffing needs created by the impending era of big data, a workshop (iNeuro Project) was convened November 13-14, 2014. Participants included data resource providers, bioinformatics/analytics trainers, computer scientists, library scientists, and neuroscience educators...
2016: Frontiers in Neuroinformatics
Hong Jiang, Xu Xiong
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Association Between Periodontitis and Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis. Esteves Lima RP, es Cyrino RM, Dutra BC, da Silveira JO, Martins CC, Cota LOM, Costa FO. J Periodontol 2016;87(1):48-57. SOURCE OF FUNDING: The research was supported by the Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil), the Minas Gerais State Research Foundation (FAPEMIG, Brazil), the National Council of Scientific and Technological Development (CNPq, Brazil), and the Dean of Research from the Federal University of Minas Gerais (PRPq/UFMG, Brazil) TYPE OF STUDY/DESIGN: Systematic review with meta-analysis...
June 2016: Journal of Evidence-based Dental Practice
Michael Nehls
The aim of this review is to propose a Unified Theory of Alzheimer's disease (UTAD) that integrates all key behavioural, genetic and environmental risk factors in a causal chain of etiological and pathogenetic events. It is based on three concepts that emanate from human's evolutionary history: (1) The grandmother-hypothesis (GMH), which explains human longevity due to an evolutionary advantage in reproduction by trans-generational transfer of acquired knowledge. Consequently it is argued that mental health at old-age must be the default pathway of humans' genetic program and not development of AD...
2016: Journal of Molecular Psychiatry
Ye Zhao, Zhaolei Jiang, Wei-Chung Tsai, Yuan Yuan, Kroekkiat Chinda, Eue-Keun Choi, Michael C Fishbein, Shien-Fong Lin, Peng-Sheng Chen, Thomas H Everett
BACKGROUND: Simultaneous activation of the stellate ganglion (SG), the ligament of Marshall (LOM), and the ganglionated plexi often precedes the onset of paroxysmal atrial tachyarrhythmia (PAT). OBJECTIVE: The purpose of this study was to test the hypothesis that ablation of the LOM and the superior left ganglionated plexi (SLGP) reduces atrial vulnerability and results in remodeling of the SG. METHODS: Nerve activity was correlated to PAT and ventricular rate (VR) at baseline, after ablation of the LOM and SLGP, and after atrial fibrillation...
October 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Lionel Schilliger, Véronique Mentré, Rachel E Marschang, Alexandra Nicolier, Barbara Richter
A 2-month-old juvenile central bearded dragon was presented for anorexia and cachexia. Another specimen from the same cage had died suddenly 2 weeks prior. Fecal analysis revealed a high quantity of Isospora amphiboluri and a few pinworm eggs. Other examinations were not performed and the animal died a few days later despite supportive care. A third individual from the same cage presented with anorexia and a distended cœlom and was euthanized. In this third dragon, histological examination revealed intestinal coccidiosis, basophilic intranuclear inclusions compatible with adenovirus infection, acute hepatic necrosis with intrahepatocytic and intraenteritic organisms typical of microsporidia and renal gout...
July 7, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Alessandro Mussa, Cristina Molinatto, Giuseppina Baldassarre, Evelise Riberi, Silvia Russo, Lidia Larizza, Andrea Riccio, Giovanni Battista Ferrero
OBJECTIVE: To compare tumor risk in the 4 Beckwith-Wiedemann syndrome (BWS) molecular subgroups: Imprinting Control Region 1 Gain of Methylation (ICR1-GoM), Imprinting Control Region 2 Loss of Methylation (ICR2-LoM), Chromosome 11p15 Paternal Uniparental Disomy (UPD), and Cyclin-Dependent Kinase Inhibitor 1C gene (CDKN1C) mutation. STUDY DESIGN: Studies on BWS and tumor development published between 2000 and 2015 providing (epi)genotype-cancer correlations with histotype data were reviewed and meta-analysed with cancer histotypes as measured outcome and (epi)genotype as exposure...
September 2016: Journal of Pediatrics
Sanghamitra Majumdar, Jose R Peralta-Videa, Jesica Trujillo-Reyes, Youping Sun, Ana C Barrios, Genhua Niu, Juan P Flores- Margez, Jorge L Gardea-Torresdey
Soil organic matter plays a major role in determining the fate of the engineered nanomaterials (ENMs) in the soil matrix and effects on the residing plants. In this study, kidney bean plants were grown in soils varying in organic matter content and amended with 0-500mg/kg cerium oxide nanoparticles (nano-CeO2) under greenhouse condition. After 52days of exposure, cerium accumulation in tissues, plant growth and physiological parameters including photosynthetic pigments (chlorophylls and carotenoids), net photosynthesis rate, transpiration rate, and stomatal conductance were recorded...
November 1, 2016: Science of the Total Environment
Tatiana Martelloni, Paolo Tomassetti, Paola Gennaro, Danilo Vani, Emma Persia, Marco Persiano, Riccardo Falchi, Salvatore Porrello, Mauro Lenzi
Superficial soft sediment resuspension and partial fragmentation of high density opportunistic macroalgal mats were investigated by boat to determine the impact on zoobenthic assemblages in a eutrophic Mediterranean lagoon. Sediment resuspension was used to oxidise superficial organic sediments as a method to counteract the effects of eutrophication. Likewise, artificial decay of macroalgal mat was calculated to reduce a permanent source of sediment organic matter. An area of 9ha was disturbed (zone D) and two other areas of the same size were left undisturbed (zones U)...
September 15, 2016: Marine Pollution Bulletin
Susanne Eriksen Boonen, Andrea Freschi, Rikke Christensen, Federica Maria Valente, Dorte Launholt Lildballe, Lucia Perone, Orazio Palumbo, Massimo Carella, Niels Uldbjerg, Angela Sparago, Andrea Riccio, Flavia Cerrato
BACKGROUND: The overgrowth-associated Beckwith-Wiedemann syndrome (BWS) and the undergrowth-associated Silver-Russell syndrome (SRS) are characterized by heterogeneous molecular defects affecting a large imprinted gene cluster at chromosome 11p15.5-p15.4. While maternal and paternal duplications of the entire cluster consistently result in SRS and BWS, respectively, the phenotypes associated with smaller duplications are difficult to predict due to the complexity of imprinting regulation...
2016: Clinical Epigenetics
Csaba Szekely, Stephen D Atkinson, Kalman Molnar, Laszlo Egyed, Andras Gubanyi, Gabor Cech
Myxozoans (Cnidaria: Myxozoa) are almost exclusively endoparasites of aquatic vertebrates and invertebrates, with the notable exception being two species of Soricimyxum Prunescu, Prunescu, Pucek et Lom, 2007 described from terrestrial shrews (Soricidae) in central Europe. Myxospores of the two parasites are morphologically indistinguishable, but have SSU rDNA sequences that differ by about 4%. Herein, we report additional molecular and histology data from Soricimyxum fegati Prunescu, Prunescu, Pucek et Lom, 2007 from common shrew (Sorex araneus Linnaeus) from Hungary, and add a new geographic record for S...
2016: Folia Parasitologica
Frederic Brioude, Carole Nicolas, Isabelle Marey, Stephan Gaillard, Michèle Bernier, Cristina Das Neves, Yves Le Bouc, Philippe Touraine, Irene Netchine
BACKGROUND: Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome with an increased risk of cancer. Most BWS patients show a molecular defect in the 11p15 region that contains imprinted genes. BWS has been associated with malignant neoplasms during infancy. Descriptions of benign tumors, especially in adult patients, are rarer. METHODS/RESULTS: We report the case of a BWS patient with pituitary adenoma caused by loss of methylation (LOM) at ICR2 (locus CDKN1C/KCNQ1OT1)...
June 3, 2016: Hormone Research in Pædiatrics
Young Joo Suh, Sak Lee, Dong Jin Im, Suyon Chang, Yoo Jin Hong, Hye-Jeong Lee, Jin Hur, Byoung Wook Choi, Byung-Chul Chang, Chi Young Shim, Geu-Ru Hong, Young Jin Kim
BACKGROUND: The added value of cardiac computed tomography (CT) with transesophageal echocardiography (TEE) for evaluating mechanical aortic valve (AV) dysfunction has not yet been investigated. The purposes of this study were to investigate the added value of cardiac CT for evaluation of mechanical AVs and diagnoses of pannus compared to TEE, with surgical findings of redo-aortic valve replacement (AVR) used as a standard reference. METHODS: 25 patients who underwent redo-AVR due to mechanical AV dysfunction and cardiac CT before redo-AVR were included...
July 1, 2016: International Journal of Cardiology
Yorick Sandberg, Anton W Langerak, King H Lam, Anita W Rijneveld, Kirsten van Lom
BACKGROUND: Adult T-cell leukaemia/lymphoma (ATLL) is a rare mature T-cell malignancy that occurs in patients infected with human T-cell leukaemia virus type 1 (HTLV-1). Only a minority of HTLV-1 carriers develop neoplastic transformation to ATLL after a 40- to 60-year latency period. CASE DESCRIPTION: A 49-year-old Columbian male presented to the Emergency Department with abdominal pain, weight loss, generalized cutaneous papules and epistaxis. Extensive cytomorphological, histopathological, immunophenotypical, serological, and molecular (cyto)genetic analysis all contributed to reach the diagnosis of acute HTLV-1 associated ATLL...
2016: Nederlands Tijdschrift Voor Geneeskunde
Farhad B Hashemi, Kris Barreto, Wendy Bernhard, Pargol Hashemi, Adam Lomness, Ivan Sadowski
UNLABELLED: Understanding the mechanisms of HIV proviral latency is essential for development of a means to eradicate infection and achieve a cure. We have previously described an in vitro latency model that reliably identifies HIV expression phenotypes of infected cells using a dual-fluorescence reporter virus. Our results have demonstrated that ∼50% of infected cells establish latency immediately upon integration of provirus, a phenomenon termed early latency, which appears to occur by mechanisms that are distinct from epigenetic silencing observed with HIV provirus that establishes productive infections...
June 1, 2016: Journal of Virology
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