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https://www.readbyqxmd.com/read/29676689/intravenous-acetaminophen-for-postoperative-supratentorial-craniotomy-pain-a-prospective-randomized-double-blinded-placebo-controlled-trial
#1
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29673824/pre-and-postoperative-headache-in-patients-with-intracranial-tumors
#2
Bodil Karoline Ravn Munkvold, Lisa Millgård Sagberg, Asgeir Store Jakola, Ole Solheim
OBJECTIVE: We sought to examine prevalence of headache in patients with histopathologically verified intracranial tumors scheduled for surgery, and assess change in headache 1 and 6 months after surgical resection. Possible tumor and patient related predictors for preoperative headache and early postoperative symptom relief were also explored. METHODS: The European Organization for Research and Treatment of Cancer (EORTC) has developed a quality of life questionnaire (EORTC QLQ-C30) with a brain cancer specific module, QLQ-BN20, containing 20 questions rating symptoms the past week on an ordinal scale ranging from 1-4...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673722/density-spectral-array-of-bis-vista%C3%A2-monitoring-system-in-a-functional-hemispherectomy
#3
C Luis, E Vilà, L Moltó, A Pardo, J L Fernández Candila, S Pacreu
We present the case of an adult patient with drug-resistant epilepsy caused by extensive inflammation in the right cerebral hemisphere. She was scheduled to undergo right functional hemispherectomy, which is common in pediatric surgery, but about which few studies have been published with respect to adult patients. During the intraoperative period, the density spectral array of the bilateral bispectral index (BIS) VISTATM monitoring system was used. We observed a power increase in low frequency (0.1-4Hz) and alpha bands (8-12Hz) in the right hemisphere, where the epileptogenic focus was...
April 16, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29670465/emerging-roles-of-immune-cells-in-postoperative-cognitive-dysfunction
#4
REVIEW
Yue Liu, Yiqing Yin
Postoperative cognitive dysfunction (POCD), a long-lasting cognitive decline after surgery, is currently a major clinical problem with no clear pathophysiological mechanism or effective therapy. Accumulating evidence suggests that neuroinflammation plays a critical role in POCD. After surgery, alarmins are leaked from the injury sites and proinflammatory cytokines are increased in the peripheral circulation. Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29668847/adiponectin-determines-farnesoid-x-receptor-agonism-mediated-cardioprotection-against-post-infarction-remodeling-and-dysfunction
#5
Yunlong Xia, Fuyang Zhang, Shihao Zhao, Yueyang Li, Xiyao Chen, Erhe Gao, Xinyue Xu, Zhenyu Xiong, Xiaomeng Zhang, Jinglong Zhang, Huishou Zhao, Wei Wang, Helin Wang, Yanjie Guo, Yi Liu, Congye Li, Shan Wang, Ling Zhang, Wenjun Yan, Ling Tao
Aims: The farnesoid X receptor (FXR) is a member of the metabolic nuclear receptor superfamily that plays a critical regulatory role in cardiovascular physiology/pathology. However, the role of systemic FXR activation in the chronic phase in myocardial infarction (MI)-induced cardiac remodeling and dysfunction remains unclear. In this study, we aimed to elucidate the role of long-term FXR activation on post-MI cardiac remodeling and dysfunction. Methods and Results: Mice underwent either MI surgery or sham operation...
April 14, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29665808/critical-role-of-nlrp3-caspase-1-pathway-in-age-dependent-isoflurane-induced-microglial-inflammatory-response-and-cognitive-impairment
#6
Zhi Wang, Shiyu Meng, Lin Cao, Ying Chen, Zhiyi Zuo, Shuling Peng
BACKGROUND: Elderly patients are more likely to suffer from postoperative cognitive dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the particular pathogenesis of POCD in elderly patients remains unknown. This study is carried out to determine the critical role of the NOD-like receptor protein 3 (NLRP3)-caspase-1 pathway in isoflurane-induced cognitive impairment. METHODS: Young (6-8 months old) and aged (14 months old) healthy male C57BL/6 mice were exposed to 1...
April 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29662089/time-rescaling-reproduces-eeg-behavior-during-transition-from-propofol-anesthesia-induced-unconsciousness-to-consciousness
#7
S Boussen, A Spiegler, C Benar, M Carrère, F Bartolomei, P Metellus, R Voituriez, L Velly, N Bruder, A Trébuchon
General anesthesia (GA) is a reversible manipulation of consciousness whose mechanism is mysterious at the level of neural networks leaving space for several competing hypotheses. We recorded electrocorticography (ECoG) signals in patients who underwent intracranial monitoring during awake surgery for the treatment of cerebral tumors in functional areas of the brain. Therefore, we recorded the transition from unconsciousness to consciousness directly on the brain surface. Using frequency resolved interferometry; we studied the intermediate ECoG frequencies (4-40 Hz)...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29658939/simultaneous-recordings-of-cortical-local-field-potentials-electrocardiogram-electromyogram-and-breathing-rhythm-from-a-freely-moving-rat
#8
Yu Shikano, Takuya Sasaki, Yuji Ikegaya
Monitoring the physiological dynamics of the brain and peripheral tissues is necessary for addressing a number of questions about how the brain controls body functions and internal organ rhythms when animals are exposed to emotional challenges and changes in their living environments. In general experiments, signals from different organs, such as the brain and the heart, are recorded by independent recording systems that require multiple recording devices and different procedures for processing the data files...
April 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29653127/evaluation-of-early-chronic-functional-outcomes-and-their-relationship-to-pre-frontal-cortex-and-hippocampal-pathology-following-moderate-severe-traumatic-brain-injury
#9
Alina Arulsamy, Jason Teng, Holly Colton, Frances Corrigan, Lyndsey Collins-Praino
TBI is a significant risk factor for the development of dementia, with the interaction between structural damage from TBI and neuroinflammation potentially driving this relationship. This study investigated the early chronic post-TBI neuroinflammatory response and its relationship to both neurodegenerative pathology and functional impairment up to 3 months post-injury. Sprague-Dawley rats underwent either sham surgery or the Marmarou model of diffuse moderate-severe TBI. At 1-month and 3-months post-injury, a functional battery encompassing motor function, depressive-like behaviour, anxiety and cognition was performed...
April 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29651746/human-neural-stem-progenitor-cells-derived-from-epileptic-human-brain-in-a-self-assembling-peptide-nanoscaffold-improve-traumatic-brain-injury-in-rats
#10
Ali Jahanbazi Jahan-Abad, Sajad Sahab Negah, Hassan Hosseini Ravandi, Sedigheh Ghasemi, Maryam Borhani-Haghighi, Walter Stummer, Ali Gorji, Maryam Khaleghi Ghadiri
Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Among different cell types, human neural stem cells cultured in self-assembling peptide scaffolds have been suggested as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/PCs) derived from epileptic human brain and human adipose-derived stromal/stem cells (hADSCs) seeded in PuraMatrix hydrogel (PM) on brain function after TBI in an animal model of brain injury...
April 12, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29642894/activation-of-melanocortin-receptor-4-with-ro27-3225-attenuates-neuroinflammation-through-ampk-jnk-p38-mapk-pathway-after-intracerebral-hemorrhage-in-mice
#11
Shengpan Chen, Lianhua Zhao, Prativa Sherchan, Yan Ding, Jing Yu, Derek Nowrangi, Jiping Tang, Ying Xia, John H Zhang
BACKGROUND: Neuroinflammation plays an important role in the pathogenesis of intracerebral hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 (MC4R) has been shown to elicit anti-inflammatory effects in many diseases. The objective of this study was to explore the role of MC4R activation on neuroinflammation in a mouse ICH model and to investigate the contribution of adenosine monophosphate-activated protein kinase (AMPK)/c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) pathway in MC4R-mediated protection...
April 11, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29625312/strokectomy-and-extensive-cerebro-spinal-fluid-drainage-for-the-treatment-of-space-occupying-cerebellar-ischemic-strokes
#12
Fulvio Tartara, Daniele Bongetta, Elena Virginia Colombo, Carlo Bortolotti, Marco Cenzato, Ermanno Giombelli, Paolo Gaetani, Francesco Zenga, Giulia Pilloni, Alfonso Ciccone, Maria Sessa
BACKGROUND: and Purpose: Cerebellar ischemia may lead to space-occupying edema, resulting in potentially fatal complications. Different surgical procedures have been reported to create space for the swollen ischemic brain; still, both the type and timing of surgical treatments are debated in literature. We present here a case series of patients treated with a unilateral craniotomy to perform a cerebellar strokectomy and extensive cerebro-spinal fluid drainage without osteo-dural posterior fossa decompression...
April 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29625310/glioneuronal-heterotopia-presenting-as-a-cerebellopontine-angle-tumor-of-the-cranial-nerve-viii-case-report
#13
M Peris-Celda, C Giannini, F E Diehn, L J Eckel, B A Neff, J J Van Gompel
BACKGROUND: Vestibular schwannomas and meningiomas account for the great majority of lesions arising in the cerebellopontine angle (CPA). In this report, we present a case of glioneuronal heterotopia, also known as glioneuronal hamartoma, arising from the VIII cranial nerve, which is an extremely uncommon lesion. Important radiologic and surgical aspects are reviewed, which may help in early recognition and intraoperative decision making when these lesions are encountered. CASE DESCRIPTION: A healthy 29-year-old female presented with intermittent right facial numbness...
April 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29619931/approaches-to-radiotherapy-in-metastatic-spinal-cord-compression
#14
Morten Hiul Suppl
Metastatic spinal cord compression is caused by the progression of metastatic lesions within the vicinity of the spinal cord. The consequences are very severe with loss of neurological function and severe pain. The standard treatment is surgical intervention followed by radiotherapy or radiotherapy alone. However, the majority of patients are treated with radiotherapy only due to contraindications to surgery and technical inoperability. Stereotactic body radiotherapy is a technology to deliver higher radiation dose to the radiotherapy target with the use of spatial coordinates...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619099/the-impact-of-deep-brain-stimulation-on-the-quality-of-life-and-swallowing-in-individuals-with-parkinson-s-disease
#15
Maira Rozenfel Olchik, Marciéle Ghisi, Annelise Ayres, Arthur Francisco Shumacher Schuh, Paulo Petry Oppitz, Carlos Roberto de Mello Rieder
Introduction  Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD). However, there is little evidence regarding the effect of DBS on dysphagia. Objective  To assess the swallowing and quality of life of individuals with PD before and after DBS surgery. Methods  Our sample consisted of people who had undergone DBS surgery in a referral hospital in the state of Rio Grande do Sul, Brazil. The inclusion criteria were a diagnosis of PD and having undergone DBS surgery. A cognitive screening, through a questionnaire about depression and quality of life, was conducted...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29618155/von-willebrand-factor-aggravates-hepatic-ischemia-reperfusion-injury-by-promoting-neutrophil-recruitment-in-mice
#16
Yasuyuki Urisono, Asuka Sakata, Hideto Matsui, Shogo Kasuda, Shiro Ono, Kiyomi Yoshimoto, Kenji Nishio, Masayuki Sho, Masashi Akiyama, Toshiyuki Miyata, Kazuo Okuchi, Satoshi Nishimura, Mitsuhiko Sugimoto
Hepatic ischaemia-reperfusion (I/R) injury is a serious liver damage that critically influences the clinical outcome of liver surgery or transplantation. Since recent studies indicated the critical involvement of von Willebrand factor (VWF) in reperfusion injuries of brain and myocardium, we hypothesized that VWF-dependent thrombotic or inflammatory responses also play a role in hepatic I/R injury. Using a mouse model of hepatic I/R injury, we explored the functional relevance of the VWF-ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) axis in this pathologic condition...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29616521/the-relationship-between-cerebral-oxygen-saturation-and-quantitative-metrics-of-neurological-function-after-coronary-bypass-surgery-a-feasibility-study
#17
Joanna S Semrau, Stephen H Scott, Andrew G Hamilton, Dimitri Petsikas, Darrin M Payne, Gianluigi Bisleri, Tarit Saha, J Gordon Boyd
BACKGROUND: It is well-known that patients undergoing coronary artery bypass grafting (CABG) surgery may experience neurological dysfunction following their operation. However, the nature of this dysfunction has not been properly quantified. Furthermore, the relationship between post-operative impairment and cerebral oxygen saturation during surgery has remained unclear. This study aims to define the feasibility of using robotic technology to quantify post- CABG neurocognitive function, and to correlate these objective metrics with intraoperative brain tissue oxygen...
April 3, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29609083/constructional-apraxia-in-elderly-patients-with-brain-tumors-considerations-with-an-up-to-date-review-of-the-literature
#18
Giorgia Abete Fornara, Andrea Di Cristofori, Giulio Andrea Bertani, Giorgio Carrabba, Barbara Zarino
BACKGROUND: Constructional apraxia (CA) is a neuropsychological impairment of either basic perceptual and motor abilities, or executive functions, in absence of any kind of motor or perceptual deficit. Considering patients with focal brain tumors, CA is common in left or right parietal and parieto-occipital lesions. In neuropsychology, Rey-Osterrieth Complex Figure test (ROCF) (or parallel forms) is commonly used for the assessment of CA. This study stems from a clinical observation of a difficulty with CA tests for the majority of neurosurgical elderly patients without occipito-parietal lesions...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29604277/jip3-deficiency-attenuates-cardiac-hypertrophy-by-suppression-of-jnk-pathway
#19
Qinghua Ma, Yuxiu Liu, Lianghua Chen
Pathological cardiac hypertrophy is a leading cause of morbidity and mortality worldwide; however, our understanding of the molecular mechanisms revealing the disease is still unclear. In the present study, we suggested that c-Jun N-terminal kinase (JNK)-interacting protein 3 (JIP3), involved in various cellular processes, played an essential role in regulating pathological cardiac hypertrophy through in vivo and in vitro studies. JIP3 was highly expressed in human hearts with hypertrophic cardiomyopathy (HCM), and in mouse hypertrophic hearts...
March 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29602604/hair-sparing-does-not-compromise-real-time-magnetic-resonance-imaging-guided-stereotactic-laser-fiber-placement-for-temporal-lobe-epilepsy
#20
Shikha Singh, Kevin K Kumar, Matthew J Rabon, Dana Dolce, Casey H Halpern
Pre-operative scalp shaving is conventionally thought to simplify postoperative cranial wound care, lower the rate of wound infections, and ease optimal incision localization. Over the past few decades, some neurosurgeons have refrained from scalp shaving in order to improve patient satisfaction with brain surgery. However, this hair-sparing approach has not yet been explored in the growing field of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT). This study investigated the initial impact of a no-shave technique on post-operative wound infection rate as well as on entry and target accuracy in MRgLITT for mesial temporal epilepsy...
March 27, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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