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Functional brain surgery

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https://www.readbyqxmd.com/read/29456690/protective-effects-of-recombinant-human-brain-natriuretic-peptide-in-perioperative-period-during-open-heart-surgery
#1
Yunbin Xu, Yong Li, Weiguo Bao, Shi Qiu
The aim of the present study was to evaluate the protective effects and safety aspects of recombinant human brain natriuretic peptide (rhBNP) on cardiac functions of patients undergoing open-heart surgery during perioperative period. In total, 150 patients undergoing open heart surgery in the Second Hospital of Shandong Universty from August 2015 to July 2016 were randomly divided into control group and observation group each with 75 cases. Patients in control group were treated by routine rehabilitation while patients in the observation group were treated by both the routine rehabilitation and rhBNP...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29452315/technical-aspects-of-awake-craniotomy-with-mapping-for-brain-tumors-in-a-limited-resource-setting
#2
Rafael Teixeira Magalhaes Leal, Bruno Mendonça Barcellos, Jose Alberto Landeiro
BACKGROUND: Brain tumor surgery near or within eloquent regions is increasingly common and is associated with a high risk of neurological injury. Awake craniotomy with mapping has been shown to be a valid method to preserve neurological function while increasing the extent of resection. However, the technique used varies greatly among centers. Most count on professionals such as neuropsychologists, speech therapists, neurophysiologists or neurologists to help in intraoperative patient evaluation...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451447/peripheral-nerve-grafts-implanted-into-the-substantia-nigra-in-patients-with-parkinson-s-disease-during-deep-brain-stimulation-surgery-1-year-follow-up-study-of-safety-feasibility-and-clinical-outcome
#3
Craig G van Horne, Jorge E Quintero, John T Slevin, Amelia Anderson-Mooney, Julie A Gurwell, Andrew S Welleford, John R Lamm, Renee P Wagner, Greg A Gerhardt
OBJECTIVE Currently, there is no treatment that slows or halts the progression of Parkinson's disease. Delivery of various neurotrophic factors to restore dopaminergic function has become a focus of study in an effort to fill this unmet need for patients with Parkinson's disease. Schwann cells provide a readily available source of such factors. This study presents a 12-month evaluation of safety and feasibility, as well as the clinical response, of implanting autologous peripheral nerve grafts into the substantia nigra of patients with Parkinson's disease at the time of deep brain stimulation (DBS) surgery...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29447794/plasticity-after-pediatric-cochlear-implantation-implication-from-changes-in-peripheral-plasma-level-of-bdnf-and-auditory-nerve-responses
#4
Razieh Alemi, Masoud Motassadi Zarandy, Mohammad Taghi Joghataei, Ali Eftekharian, Mohammad Reza Zarrindast, Nasim Vousooghi
INTRODUCTION: Sensory neural hearing loss could lead to some structural and physiological changes in the auditory pathways, such as alteration in the expression of neurotrophins. These factors, especially Brain-Derived Neurotrophic Factor (BDNF), play an important role in synaptic functions and experience-related plasticity. Restoring cochlear function after hearing loss is possible through cochlear implantation (CI). Evaluation of the blood concentration changes of neurotrophins as prerequisites of plasticity could help scientists to determine the prognosis of CI as in the candidacy procedure or enhancing prosthesis function by adding the exact needed amount of BDNF to the electrode array...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29439655/high-fat-diet-aggravates-postoperative-cognitive-dysfunction-in-aged-mice
#5
Lan Wei, Minmin Yao, Zhimeng Zhao, Hui Jiang, Shengjin Ge
BACKGROUND: Silent Information Regulator 1 (Sirt1) and apoptosis play key roles in postoperative cognitive dysfunction (POCD). Consuming a high-fat diet (HFD), a prevalent type of diet in modern society, has been increasingly recognized as contributing to neurodegenerative diseases. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functional correlations between HFD and POCD. METHODS: Thirty-two aged C57BL/6 male mice were randomly divided into 2 groups: an ad libitum (AL) group (fed a regular diet) and high-fat diet (HF) group (fed a high-fat diet)...
February 13, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29439328/impact-of-total-knee-arthroplasty-with-general-anesthesia-on-brain-networks-cognitive-efficiency-and-ventricular-volume-predict-functional-connectivity-decline-in-older-adults
#6
Haiqing Huang, Jared Tanner, Hari Parvataneni, Mark Rice, Ann Horgas, Mingzhou Ding, Catherine Price
 Using resting state functional magnetic resonance imaging (RS-fMRI), we explored: 1) pre- to post-operative changes in functional connectivity in default mode, salience, and central executive networks after total knee arthroplasty (TKA) with general anesthesia, and 2) the contribution of cognitive/brain reserve metrics these resting state functional declines. Individuals age 60 and older electing unilateral total knee arthroplasty (TKA; n = 48) and non-surgery peers with osteoarthritis (n = 45) completed baseline cognitive testing and baseline and post-surgery (post-baseline, 48-h post-surgery) brain MRI...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29435967/-the-effect-of-age-on-the-prognosis-of-patients-with-traumatic-brain-injury-who-undergo-a-craniotomy-analysis-of-a-surgical-series
#7
I J Gilete-Tejero, H Z Ippolito-Bastidas, L M Bernal-Garcia, J Mata-Gomez, R Garcia-Moreno, M Ortega-Martinez, J M Cabezudo-Artero
INTRODUCTION: In our setting, the ageing of the population has led to management of traumatic brain injury (TBI) in the later stages of life becoming an increasingly frequent problem. AIM: To evaluate the association between age and the functional and survival prognosis of patients who have undergone surgery due to TBI. PATIENTS AND METHODS: We performed a retrospective analysis of a series of 404 patients submitted to surgery between the years 2000 and 2015: 144 youngsters (12-44 years), 77 adults (45-64 years), 148 geriatric patients (65-79 years) and 26 'super geriatric' patients (> 80 years)...
February 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29434566/assessment-of-platelet-function-in-traumatic-brain-injury-a-retrospective-observational-study-in-the-neuro-critical-care-setting
#8
Caroline Lindblad, Eric Peter Thelin, Michael Nekludov, Arvid Frostell, David W Nelson, Mikael Svensson, Bo-Michael Bellander
Background: Despite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques. Multiple electrode aggregometry (MEA) measures platelet function and could aid in coagulopathy assessment following TBI. The aims of this study were to evaluate MEA temporal dynamics, influence of concomitant therapy, and its capabilities to predict lesion progression and clinical outcome in a TBI cohort...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29432943/functional-based-resection-does-not-worsen-quality-of-life-in-patients-harboring-a-diffuse-low-grade-glioma-involving-eloquent-brain-regions-a-prospective-cohort-study
#9
Jun Muto, Edouard Dezamis, Odile Rigaux-Viode, Sophie Peeters, Alexandre Roux, Marc Zanello, Charles Mellerio, Xavier Sauvageon, Pascale Varlet, Catherine Oppenheim, Johan Pallud
OBJECTIVE: We assessed the impact of surgery on postoperative cognitive function and ability to work in adult patients harboring a diffuse low-grade glioma involving eloquent brain regions and having a functional-based maximal surgical resection using intraoperative corticosubcortical mapping under awake conditions. METHODS: We prospectively included 39 consecutive diffuse IDH-mutant low-grade glioma patients without preoperative and adjuvant oncological treatment and assessed preoperative (mean 24...
February 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29431106/beneficial-effect-of-mas-receptor-deficiency-on-vascular-cognitive-impairment-in-the-presence-of-angiotensin-ii-type-2-receptor
#10
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan-No, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi
BACKGROUND: The classical renin-angiotensin system is known as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. The angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis is known to exert antagonistic actions against the classical renin-angiotensin system axis in the cardiovascular system. However, its roles in the brain remain unclear. We examined possible roles of the angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis in cognitive function, employing vascular cognitive impairment model mice...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29429559/epo-improved-neurologic-outcome-in-rat-pups-late-after-traumatic-brain-injury
#11
Michelle E Schober, Daniela F Requena, Christopher K Rodesch
In adult rats, erythropoietin improved outcomes early and late after traumatic brain injury, associated with increased levels of Brain Derived Neurotrophic Factor. Using our model of pediatric traumatic brain injury, controlled cortical impact in 17-day old rats, we previously showed that erythropoietin increased hippocampal neuronal fraction in the first two days after injury. Erythropoietin also decreased activation of caspase3, an apoptotic enzyme modulated by Brain Derived Neurotrophic Factor, and improved Novel Object Recognition testing 14 days after injury...
February 8, 2018: Brain & Development
https://www.readbyqxmd.com/read/29421977/chronic-alterations-in-systemic-immune-function-after-traumatic-brain-injury
#12
Rodney Ritzel, Sarah Doran, James Barrett, Rebecca Henry, Elise Ma, Alan Faden, David J Loane
There is a compelling link between severe brain trauma and immunosuppression in traumatic brain injury (TBI) patients. Although acute changes in the systemic immune compartment have been linked to outcome severity, the long-term consequences of TBI on systemic immune function is unknown. Here, adult male C57Bl/6 mice were subjected to moderate-level controlled cortical impact (CCI) or sham surgery and systemic immune function was evaluated at 1, 3, 7, 14, and 60 days post-injury. Bone marrow, blood, thymus, and spleen were examined by flow cytometry to assess changes in immune composition, reactive oxygen species (ROS) production, phagocytic activity, and cytokine production...
February 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29420377/modified-lengthening-temporalis-myoplasty-involving-an-extended-lazy-s-incision-to-avoid-facial-scar-formation
#13
Tomito Oji, Akiteru Hayashi, Akihiro Ogino, Kiyoshi Onishi
BACKGROUND: Lengthening temporalis myoplasty is a faster and less invasive alternative to free muscle transfer for smile reconstruction. However, it requires a nasolabial fold incision, which leaves a midfacial scar. Based on esthetic considerations, a modified approach, involving an extended lazy-S (parotidectomy) incision instead of a nasolabial fold incision, was developed. METHODS: A cadaveric study involving 10 hemifaces was conducted. From February 2013 to March 2016, the modified lengthening temporalis myoplasty procedure was employed in 10 patients...
February 7, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29419328/brain-focused-ultrasound-what-s-the-fus-all-about-a-review-of-current-and-emerging-neurological-applications
#14
Laure Bretsztajn, Wladyslaw Gedroyc
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) allows for precise non-invasive thermal ablation of target tissues for a wide range of clinical applications. It is an innovative and rapidly expanding technology which has already established itself as an effective and safe incisionless alternative in the treatment of various soft tissue tumours, with many more research studies underway to extend its therapeutic envelope. The non-invasiveness of the procedure makes FUS particularly attractive in functional neurosurgery, where existing treatment options are not suitable for all patients...
February 8, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29411466/writing-fluency-in-patients-with-low-grade-glioma-before-and-after-surgery
#15
Malin Antonsson, Charlotte Johansson, Lena Hartelius, Ingrid Henriksson, Francesca Longoni, Åsa Wengelin
BACKGROUND: Low-grade glioma (LGG) is a type of brain tumour often situated in or near areas involved in language, sensory or motor functions. Depending on localization and tumour characteristics, language or cognitive impairments due to tumour growth and/or surgical resection are obvious risks. One task that may be at risk is writing, both because it requires intact language and memory function and because it is a very complex and cognitively demanding task. The most commonly reported language deficit in LGG patients is oral lexical-retrieval difficulties, and poor lexical retrieval would be expected to affect writing fluency...
February 7, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29406402/impaired-cognitive-performance-in-endothelial-nitric-oxide-synthase-knock-out-mice-after-ischemic-stroke-a-pilot-study
#16
Shanshan Li, Yao Wang, Ze Jiang, Yaping Huai, James K Liao, Kaari A Lynch, Ross Zafonte, Lisa J Wood, Qing Mei Wang
OBJECTIVES: Cognitive dysfunction and dementia are common following ischemic stroke. Endothelial nitric oxide synthase (eNOS) has been found to play an important role in neurological function and cognition. The purpose of the present study was to assess the specific role of eNOS in cognitive performance after stroke. DESIGN: Male wildtype (WT) and mice lacking eNOS (eNOS) underwent middle cerebral artery occlusion (MCAO) or sham-surgery. Primary outcomes were repeated measures of neurological score, limb asymmetry, sensory/motor function and spatial memory/learning assessed at intervals up to 28-days post-surgery...
February 5, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29397529/protein-energy-malnutrition-exacerbates-stroke-induced-forelimb-abnormalities-and-dampens-neuroinflammation
#17
Mariam Alaverdashvili, Sally Caine, Xue Li, Mark J Hackett, Michael P Bradley, Helen Nichol, Phyllis G Paterson
Protein-energy malnutrition (PEM) pre-existing at stroke onset is believed to worsen functional outcome, yet the underlying mechanisms are not fully understood. Since brain inflammation is an important modulator of neurological recovery after stroke, we explored the impact of PEM on neuroinflammation in the acute period in relation to stroke-initiated sensori-motor abnormalities. Adult rats were fed a low-protein (LP) or normal protein (NP) diet for 28 days before inducing photothrombotic stroke (St) in the forelimb region of the motor cortex or sham surgery; the diets continued for 3 days after the stroke...
February 3, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29393749/increase-in-callosal-angle-and-decrease-in-ventricular-volume-after-shunt-surgery-in-patients-with-idiopathic-normal-pressure-hydrocephalus
#18
Johan Virhammar, Katarina Laurell, Kristina Giuliana Cesarini, Elna-Marie Larsson
OBJECTIVE Postoperative decrease in ventricle size is usually not detectable either by visual assessment or by measuring the Evans index in patients with idiopathic normal pressure hydrocephalus (iNPH). The aim of the present study was to investigate whether the angle between the lateral ventricles (the callosal angle [CA]) increases and ventricular volume decreases after shunt surgery in patients with iNPH. METHODS Magnetic resonance imaging of the brain was performed before and 3 months after shunt surgery in 18 patients with iNPH...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29393419/hmgb1-mediates-microglia-activation-via-the-tlr4-nf-%C3%AE%C2%BAb-pathway-in-coriaria-lactone-induced-epilepsy
#19
Yunbo Shi, Lingli Zhang, Junfang Teng, Wang Miao
Epilepsy is a chronic and recurrent disease of the central nervous system, with a complex pathology. Recent studies have demonstrated that the activation of glial cells serve an important role in the development of epilepsy. The objective of the present study was to investigate the role of high‑mobility group box‑1 (HMGB1) in mediating the activation of glial cells through the toll‑like receptor 4 (TLR4)/nuclear factor (NF)‑κB signaling pathway in seizure, and the underlying mechanism. The brain tissue of post‑surgery patients with intractable epilepsy after resection and the normal control brain tissue of patients with craniocerebral trauma induced intracranial hypertension were collected...
January 25, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29390108/dural-and-pial-pain-sensitive-structures-in-humans-new-inputs-from-awake-craniotomies
#20
Denys Fontaine, Fabien Almairac, Serena Santucci, Charlotte Fernandez, Radhouane Dallel, Johan Pallud, Michel Lanteri-Minet
Our knowledge on intracranial pain-sensitive structures in humans comes essentially from observations during neurosurgical procedures performed in awake patients. It is currently accepted that intracranial pain-sensitive structures are limited to the dura mater and its feeding vessels and that small cerebral vessels and pia mater are insensitive to pain, which is inconsistent with some neurosurgical observations during awake craniotomy procedures. We prospectively collected observations of painful events evoked by mechanical stimulation (touching, stretching, pressure, or aspiration) of intracranial structures during awake craniotomies, routinely performed for intraoperative functional mapping to tailor brain tumour resection in the eloquent area...
January 29, 2018: Brain: a Journal of Neurology
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