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Reducing alcohol intake

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https://www.readbyqxmd.com/read/29789709/consumption-of-green-tea-but-not-coffee-is-associated-with-the-oral-health-related-quality-of-life-among-an-older-japanese-population-kyoto-kameoka-cross-sectional-study
#1
Hinako Nanri, Yosuke Yamada, Aya Itoi, Emi Yamagata, Yuya Watanabe, Tsukasa Yoshida, Motoko Miyake, Heiwa Date, Kazuko Ishikawa-Takata, Mitsuyoshi Yoshida, Takeshi Kikutani, Misaka Kimura
BACKGROUND/OBJECTIVES: The consumption of both green tea and coffee is known to induce positive health effects; however, it remains unclear whether there is an association between the consumption of these beverages and oral health-related quality of life (OHRQoL). Thus, the present study investigated the relationship between the consumption of green tea and coffee and OHRQoL. SUBJECTS/METHODS: We analyzed cross-sectional baseline data in 2012. The subjects were 7514 Japanese participants (3563 men, 3951 women; ≥65 years of age)...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29788220/obstructive-sleep-apnea-syndrome-and-metabolic-diseases
#2
Min Li, Xiaoying Li, Yan Lu
With the rapid changes of lifestyle in modern society, including high nutritional intake and reduced physical activity, the incidence of metabolic diseases is increasing year by year. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder, usually characterized by sudden pauses of breathing during sleep with interrupted sleep rhythm. Although the pathological mechanism remains poorly understood, it is strongly associated with metabolic diseases, including obesity, insulin resistance, type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD)...
May 18, 2018: Endocrinology
https://www.readbyqxmd.com/read/29782302/reasons-for-not-using-condoms-among-heterosexual-men-in-belgrade-serbia
#3
Milan Bjekić, Sandra Sipetić-Grujičić, Hristina Vlajinac, Aleksandra Nikolić
Dear Editor, Proper and consistent use of male condoms can be a highly effective method of preventing the transmission of sexually transmitted infections (STIs) and HIV (1), but this method relies on men's willingness and ability to use condoms. In the United States of America, about 20% overall and less than 50% of adults with multiple partners used a condom at last intercourse (2). In Serbia in 2013 (3), 50.0% of women and 62.5% of men aged 15-49 who had more than one partner in the past year used a condom during their last intercourse...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781380/finally-a-regimen-to-extend-human-life-expectancy
#4
James Larrick, Andrew R Mendelsohn
The US has the most expensive healthcare system worldwide. Yet measures of healthspan and life expectancy are well below the major industrialized nations. With the US population aged 65 and older projected to double by mid-century a healthcare crisis is looming. Within this context huge interest and investment has emerged in technologies and drugs to address aging with an expected benefit to healthspan. The thesis being that such basic interventions will reduce morbidity caused by many chronic diseases where biological age itself is the major risk factor...
May 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29775679/identification-and-validation-of-midbrain-kcnq4-regulation-of-heavy-alcohol-consumption-in-rodents
#5
Natalie S McGuier, Jennifer A Rinker, Reginald Cannady, Diana B Fulmer, Sara R Jones, Michaela Hoffman, Patrick J Mulholland
Currently available pharmacotherapies for treating alcohol use disorder (AUD) suffer from deleterious side effects and are not efficacious in diverse populations. Clinical and preclinical studies provide evidence that the Kcnq family of genes that encode KV 7 channels influence alcohol intake and dependence. KV 7 channels are a class of slowly activating voltage-dependent K+ channels that regulate neuronal excitability. Studies indicate that the KV 7 channel positive modulator retigabine can decrease dopaminergic neuron firing, alter dopamine (DA) release, and reduce alcohol intake in heavy drinking rodents...
May 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29769465/effects-of-oral-calcium-dosage-and-timing-on-ethanol-induced-sensitization-of-locomotion-in-dba-2-mice
#6
Chikako Shimizu, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima
Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with alcohol. Therefore, we investigated the association among oral Ca ingestion, EtOH-induced locomotor sensitization, and plasma Ca levels on how to consume Ca for moderate drinking. We used DBA/2 CrSlc mice, and CaCl2 as water-soluble Ca salts...
May 16, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29763272/colorectal-cancer-screening-and-prevention
#7
Thad Wilkins, Danielle McMechan, Asif Talukder
Colorectal cancer is a common cause of morbidity and mortality in the United States. Most colorectal cancers arise from preexisting adenomatous or serrated polyps. The incidence and mortality of colorectal cancer can be reduced with screening of average-risk adults 50 to 75 years of age. Randomized controlled trials show evidence of reduced colorectal cancer-specific mortality with guaiac-based fecal occult blood tests and flexible sigmoidoscopy. There are no randomized controlled trials on the effectiveness of colonoscopy to reduce colorectal cancer-specific mortality; however, several randomized controlled trials comparing colonoscopy with other strategies are in progress...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761318/association-of-sugar-sweetened-beverages-consumption-with-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#8
REVIEW
Farzaneh Asgari-Taee, Nahid Zerafati-Shoae, Mohsen Dehghani, Masoumeh Sadeghi, Hamid R Baradaran, Shima Jazayeri
PURPOSE: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. METHODS: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29757972/short-term-soy-protein-isolate-feeding-prevents-liver-steatosis-and-reduces-serum-alt-and-ast-levels-in-obese-female-zucker-rats
#9
Reza Hakkak, Clinton Heath Gauss, Andrea Bell, Soheila Korourian
Non-alcoholic fatty liver disease is a common liver disorder worldwide and is associated with obesity. We investigated effects of obesity and short-term intake of soy protein with isoflavones (SPI) on body weight change, energy intake, liver steatosis, and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and leptin levels. Seventeen lean and seventeen obese ( fa / fa ) female Zucker rats were randomly assigned to either casein or SPI diet for 8 weeks. Body weight was recorded twice weekly; feed intake was measured weekly...
May 14, 2018: Biomedicines
https://www.readbyqxmd.com/read/29741556/eating-at-food-outlets-and-leisure-places-and-on-the-go-is-associated-with-less-healthy-food-choices-than-eating-at-home-and-in-school-in-children-cross-sectional-data-from-the-uk-national-diet-and-nutrition-survey-rolling-program-2008-2014
#10
Nida Ziauddeen, Polly Page, Tarra L Penney, Sonja Nicholson, Sara F L Kirk, Eva Almiron-Roig
Background: Where children eat has been linked to variations in diet quality, including the consumption of low-nutrient, energy-dense food, a recognized risk factor for obesity. Objective: The aim of this study was to provide a comprehensive analysis of consumption patterns and nutritional intake by eating location in British children with the use of a nationally representative survey. Design: Cross-sectional data from 4636 children (80,075 eating occasions) aged 1...
May 7, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29731599/alcohol-related-injuries-among-eastern-croatian-university-students
#11
Ivan Miskulin, Corinne Peek-Asa, Maja Miskulin
The aim of this study was to describe the alcohol consumption patterns and to identify the association of injury with excess drinking among Croatian students. This cross-sectional study was conducted among 845 university students by the use of the WHO AUDIT questionnaire. A total of 39.9% of the university students reported some level of excess drinking and 21.3% reported that injury to themselves or others occurred as a result of their alcohol use. Conclusively, these results demonstrate a significant need for comprehensive programs to reduce alcohol intake and associated alcohol problems, as well as programs to reduce injuries among Croatian university students...
2018: Journal of Child & Adolescent Substance Abuse
https://www.readbyqxmd.com/read/29729189/ad-libitum-mediterranean-and-low-fat-diets-both-significantly-reduce-hepatic-steatosis-a-randomized-controlled-trial
#12
Catherine Properzi, Therese A O'Sullivan, Jill L Sherriff, Helena L Ching, Garry P Jeffrey, Rachel F Buckley, Jonathan Tibballs, Gerry C MacQuillan, George Garas, Leon A Adams
Although diet induced weight loss is first-line treatment for patients with non-alcoholic fatty liver disease (NAFLD), long-term maintenance is difficult. The optimal diet for either improvement in NAFLD or associated cardio-metabolic risk factors regardless of weight loss, is unknown. We examined the effect of two ad libitum isocaloric diets [Mediterranean (MD) or Low Fat (LF)] on hepatic steatosis and cardio-metabolic risk factors. Subjects with NAFLD were randomized to a 12-week blinded dietary intervention (MD vs LF)...
May 5, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29722845/mediterranean-diet-and-risk-of-frailty-syndrome-among-women-with-type-2-diabetes
#13
Esther Lopez-Garcia, Kaitlin A Hagan, Teresa T Fung, Frank B Hu, Fernando Rodríguez-Artalejo
Background: Previous research indicates that patients with type 2 diabetes are at higher risk of becoming frail. Emerging evidence also indicates that the Mediterranean diet may prevent frailty in the older population. Objective: The aim of this study was to assess whether a Mediterranean-style diet pattern was associated with lower risk of frailty among older women with diabetes. Design: This was a prospective cohort study in 8970 women aged ≥60 y with type 2 diabetes from the Nurses' Health Study...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29719204/drug-drug-interactions-in-the-treatment-for-alcohol-use-disorders-a-comprehensive-review
#14
REVIEW
Guerzoni Simona, Pellesi Lanfranco, Pini Luigi Alberto, Caputo Fabio
Drug interactions are one of the most common causes of side effects in polypharmacy. Alcoholics are a category of patients at high risk of pharmacological interactions, due to the presence of comorbidities, the concomitant intake of several medications and the pharmacokinetic and pharmacodynamic interferences of ethanol. However, the data available on this issue are limited. These reasons often frighten clinicians when prescribing appropriate pharmacological therapies for alcohol use disorder (AUD), where less than 15% of patients receive an appropriate treatment in the most severe forms...
April 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29713786/interest-of-new-alkylsulfonylhydrazide-type-compound-in-the-treatment-of-alcohol-use-disorders
#15
Jérôme Jeanblanc, Erika Bourguet, Diana Sketriené, Céline Gonzalez, Gautier Moroy, Rémi Legastelois, Mathieu Létévé, Aurélie Trussardi-Régnier, Mickaël Naassila
RATIONALE: Recent preclinical research suggested that histone deacetylase inhibitors (HDACIs) and specifically class I HDAC selective inhibitors might be useful to treat alcohol use disorders (AUDs). OBJECTIVE: The objective of this study was to find a new inhibitor of the HDAC-1 isoenzyme and to test its efficacy in an animal model of AUDs. METHODS: In the present study, we prepared new derivatives bearing sulfonylhydrazide-type zinc-binding group (ZBG) and evaluated these compounds in vitro on HDAC-1 isoenzyme...
April 30, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29712712/impact-of-healthy-lifestyle-factors-on-life-expectancies-in-the-us-population
#16
Yanping Li, An Pan, Dong D Wang, Xiaoran Liu, Klodian Dhana, Oscar H Franco, Stephen Kaptoge, Emanuele Di Angelantonio, Meir Stampfer, Walter C Willett, Frank B Hu
Background -Americans have a shorter life expectancy compared with residents of almost all other high-income countries. We aim to estimate the impact of lifestyle factors on premature mortality and life expectancy in the US population. Methods -Using data from the Nurses' Health Study (1980-2014; n=78 865) and the Health Professionals Follow-up Study (1986-2014, n=44 354), we defined 5 low-risk lifestyle factors as never smoking, body mass index of 18.5 to 24.9 kg/m2 , ≥30 min/d of moderate to vigorous physical activity, moderate alcohol intake, and a high diet quality score (upper 40%), and estimated hazard ratios for the association of total lifestyle score (0-5 scale) with mortality...
April 30, 2018: Circulation
https://www.readbyqxmd.com/read/29710765/a-vitamin-e-enriched-antioxidant-diet-interferes-with-the-acute-adaptation-of-the-liver-to-physical-exercise-in-mice
#17
Miriam Hoene, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Hans-Ulrich Häring, Cora Weigert
Physical exercise is beneficial for general health and is an effective treatment for metabolic disorders. Vitamin E is widely used as dietary supplement and is considered to improve non-alcoholic fatty liver disease by reducing inflammation and dyslipidemia. However, increased vitamin E intake may interfere with adaptation to exercise training. Here, we explored how vitamin E alters the acute exercise response of the liver, an organ that plays an essential metabolic role during physical activity. Mice fed a control or an α-tocopherol-enriched diet were subjected to a non-exhaustive treadmill run...
April 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29709884/chronic-moderate-alcohol-drinking-alters-insulin-release-without-affecting-cognitive-and-emotion-like-behaviors-in-rats
#18
Nnamdi G Nelson, Faten A Suhaidi, Wen Xuan Law, Nu-Chu Liang
Because the consumption of alcoholic beverages prevails in society, its effects on diabetes risk is a subject of interest. Extant literature on this issue often disagrees. Here, we probed the effects of chronic moderate ethanol consumption on glucose metabolism in rats. The effect of chronic moderate alcohol drinking on depression- and anxiety-like behaviors and memory was also explored. Adolescent male and female Long-Evans rats consumed saccharin-sweetened 5% (1 week) and 10% ethanol (7 weeks) under a 7.5-h/day (Monday-Friday) access schedule...
December 16, 2017: Alcohol
https://www.readbyqxmd.com/read/29706079/modulation-of-ampk-dependent-lipogenesis-mediated-by-p2x7r-nlrp3-inflammasome-activation-contributes-to-the-amelioration-of-alcoholic-liver-steatosis-by-dihydroquercetin
#19
Yu Zhang, Quan Jin, Xia Li, Jiang Min, Ben-Wen Cui, Kai-Li Xia, Yan-Ling Wu, Li-Hua Lian, Ji-Xing Nan
Dihydroquercetin (TAX) is the most abundant dihydroflavone found in onions, milk thistle and Douglas fir bark. We investigated whether TAX could inhibit the lipid accumulation in alcoholic liver steatosis in vivo and in vitro. An in vivo model was established by intragastrically treating mice with ethanol, and an in vitro model was created by treating HepG2 cells with ethanol. TAX regulated SREBP1 and ACC expression via elevating LKB1/AMPK phosphorylation. Also, TAX upregulated SIRT1 expression, which suppressed by ethanal intake...
April 28, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29705237/%C3%AE-hydroxybutyrate-protects-from-alcohol-induced-liver-injury-via-a-hcar2-camp-dependent-pathway
#20
Yonglin Chen, Xinshou Ouyang, Rafaz Hoque, Irma Garcia-Martinez, Muhammad Nadeem Yousaf, Sarah Tonack, Stefan Offermanns, Laurent Dubuquoy, Alexandre Louvet, Philippe Mathurin, Veronica Massey, Bernd Schnabl, Ramon Alberola Bataller, Wajahat Zafar Mehal
BACKGROUND & AIMS: Sterile inflammation resulting in alcoholic hepatitis (AH) occurs unpredictably after many years of excess alcohol intake. The factors responsible for the development of AH are not known but mitochondrial damage with loss of mitochondrial function are common features. Hcar2 is a G-protein coupled receptor which is activated by β-hydroxybutyrate (BHB). We aimed to determine the relevance of the BHB-Hcar2 pathway in alcoholic liver disease. METHODS: We tested if loss of BHB production can result in increased liver inflammation...
April 27, 2018: Journal of Hepatology
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