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Vertical bone augmentation

Yeon Jung Kim, Rafael Rafael de Molon, Fausto Rioiti Horiguti, Guilherme Piragine Contador, Marco Antonio Coelho, Vinicius Ibiapina Mascarenhas, Ana Paula de Souza Faloni, Joni Augusto Cirelli, Wilson Roberto Sendyk
PURPOSE: The objective of this investigation was to assess vertical bone augmentation using deproteinized bovine bone mineral (DBBM) infused or not with recombinant human bone morphogenetic protein (rhBMP-2) in rabbit tibiae. MATERIALS AND METHODS: A total of 18 female rabbits (New Zealand) received two blocks of DBBM in each tibia. The DBBM blocks were randomly assigned into four experimental groups: DBBM (only the bone graft); DBBM associated with absorbable collagen sponge (ACS); DBBM plus rhBMP-2 (1...
March 15, 2018: International Journal of Oral & Maxillofacial Implants
Huseyin Burak Kutlu, Samir Goyushov, Bünyamin Calisan, Tolga F Tözüm
OBJECTIVE: Loss of teeth frequently results in compound horizontal and vertical alveolar bone defects. An appropriate bone structure is the key for implant placement and bony support of soft tissues. Advanced bone augmentation techniques are required for the reconstruction of these defects. This report will present a new bone block grafting technique with 12-month follow-up. METHOD: The seedling technique was used to augment the alveolar bone 3-dimensionally with autologous bone block and an osseointegrated implant in a 2-stage procedure...
March 13, 2018: Journal of Craniofacial Surgery
Adel S Alagl, Marwa Madi
Alveolar ridge deficiency is considered a major limitation for successful implant placement, as well as for the long-term success rate, especially in the anterior maxillary region. Various approaches have been developed to increase bone volume. Among those approaches, inlay and onlay grafts, alveolar ridge distraction, and guided bone regeneration have been suggested. The use of titanium mesh is a reliable method for ridge augmentation. We describe a patient who presented with a localized, combined, horizontal and vertical ridge defect in the anterior maxilla...
January 1, 2018: Journal of International Medical Research
Jonas Lorenz, Alica Kubesch, Sarah Al-Maawi, Frank Schwarz, Robert A Sader, Markus Schlee, Shahram Ghanaati
OBJECTIVES: The aim of the present study was the histological investigation of an allogeneic spongious bone block for horizontal and vertical ridge augmentation in humans. The amount of new bone, soft tissue, and residual bone substitute were histomorphometrically assessed after a mean healing period of 6 months. MATERIALS AND METHODS: Fourteen patients received augmentation with an allogeneic spongious bone block (Tutobone® , Tutogen Medical, Neunkirchen, Germany)...
March 9, 2018: Clinical Oral Investigations
Aladdin Al-Ardah, Nasser Alqahtani, Abdulaziz AlHelal, Brian Goodacre, Rajesh Swamidass, Antoanela Garbacea, Jaime Lozada
This technique describes a novel approach for planning and augmenting a large bony defect using a titanium mesh (TiMe). A 3-dimensional (3D) surgical model was virtually created from a cone beam computed tomography (CBCT) and wax-pattern of the final prosthetic outcome. The required bone volume (horizontally and vertically) was digitally augmented and then 3D printed to create a bone model. The 3D model was then used to contour the TiMe in accordance with the digital augmentation. With the contoured / preformed TiMe on the 3D printed model a positioning jig was made to aid the placement of the TiMe as planned during surgery...
March 2, 2018: Journal of Oral Implantology
Isabella Rocchietta, Luca Ferrantino, Massimo Simion
The reconstruction of deficient alveolar ridges using vertical and/or horizontal guided bone regeneration techniques allows for ideal implant placement, which is crucial for function and also for esthetically successful outcomes. Unlike in the past, when meeting a patient's functional demands was sufficient, many patients now have greater expectations from their implant restoration. Hence, it is no longer enough simply to restore the edentulous space with a functioning tooth or teeth. It has been suggested that patients now measure their final restoration using the contralateral natural tooth as the gold standard...
February 25, 2018: Periodontology 2000
Sara Bernardi, Roberto Gatto, Marco Severino, Gianluca Botticelli, Silvia Caruso, Claudio Rastelli, Ettore Lupi, Adolfo Quiroz Rojas, Enzo Iacomino, Giovanni Falisi
Aim of the study was to evaluate the reliability of 6 mm long implants compared to normal length implants placed in vertical augmented atrophic posterior mandible, supporting cemented single crowns. Thirty-six patients with bilateral posterior edentulous mandible and presented a bone availability height less than 9 mm from the mandibular canal were enrolled for the participation to this study. Patient hemi-arches were randomized to receive both 6 mm-long and normal length implants (10 mm). The technique used for the vertical bone augmentation was the "sandwich" technique, using a bone substitute block as graft...
February 13, 2018: Journal of Oral Implantology
Takako Kawasaki, Seigo Ohba, Yuya Nakatani, Izumi Asahina
The guided bone regeneration (GBR) technique is often applied to provide sufficient bone for ideal implant placement. The objective of this study was to evaluate whether GC membrane®, which has already been used for guided tissue regeneration (GTR), can also be available for GBR. Twenty-three implants in 18 patients were evaluated in the study. All patients underwent implant placement with GBR using GC membrane®. Cone-beam computed tomography was performed at 13-30 weeks after surgery and the amount of augmented bone was assessed...
February 10, 2018: Odontology
Wen-Tao Zhao, Da-Ping Qin, Xiao-Gang Zhang, Zhi-Peng Wang, Zun Tong
BACKGROUND: Clinical results have shown that different vertebral heights have been restored post-augmentation of osteoporotic vertebral compression fractures (OVCFs) and the treatment results are consistent. However, no significant results regarding biomechanical effects post-augmentation have been found with different types of vertebral deformity or vertebral heights by biomechanical analysis. Therefore, the present study aimed to investigate the biomechanical effects between different vertebral heights of OVCFs before and after augmentation using three-dimensional finite element analysis...
February 8, 2018: Journal of Orthopaedic Surgery and Research
Ji-Sun Lee, Jung-Seok Lee, Myung-Hun Kang, Ui-Won Jung, Seong-Ho Choi, Kyoo-Sung Cho
This study aimed to quantify the healing following vertical augmentation of allogenic bone blocks with/without recombinant human bone morphogenetic protein-2 (rhBMP-2) on rabbit calvaria. Experiments were performed using allogenic bone blocks which were grafted bilaterally with or without rhBMP-2 on 20 rabbit calvaria, and these animals were divided to four groups according to the use of rhBMP-2 and healing periods (2 and 8 weeks; n = 10 in each group). Onlay-type bone blocks (8 mm in diameter and 5 mm high) were fixed with a self-tapping screw after removing the cortex in the control group, and the same protocol was applied with the addition of soaking the bone blocks with rhBMP-2 for 15 min in the test group...
February 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Liping Zhao, Tao Xu, Wenjie Hu, Kwok-Hung Chung
BACKGROUND: Studies of the extracted infected-molar ridge preservation are limited. PURPOSE: To compare alterations of hard and soft tissue in infected-molar sockets receiving ridge preservation compared with natural healing. MATERIALS AND METHODS: Thirty-five infected-molar extraction sites either preserving with Bio-Gide membrane covered the Bio-Oss material or receiving natural healing procedure as controls. The soft tissue profile was evaluated before tooth extraction and after 6-month healing...
January 29, 2018: Clinical Implant Dentistry and related Research
Kazuhiro Egashira, Yoshinori Sumita, Weijian Zhong, Takashi I, Seigo Ohba, Kazuhiro Nagai, Izumi Asahina
Bone marrow concentrate (BMC), which is enriched in mononuclear cells (MNCs) and platelets, has recently attracted the attention of clinicians as a new optional means for bone engineering. We previously reported that the osteoinductive effect of bone morphogenetic protein-2 (BMP-2) could be enhanced synergistically by co-transplantation of peripheral blood (PB)-derived platelet-rich plasma (PRP). This study aims to investigate whether BMC can effectively promote bone formation induced by low-dose BMP-2, thereby reducing the undesirable side-effects of BMP-2, compared to PRP...
2018: PloS One
Amparo Aloy-Prósper, David Peñarrocha-Oltra, Maria Peñarrocha-Diago, Federico Hernández-Alfaro, Miguel Peñarrocha-Diago
PURPOSE: To evaluate the peri-implant soft and hard tissues of dental implants placed in vertically regenerated posterior mandibles with intraoral onlay block bone grafts and patient satisfaction at 3-year follow-up. MATERIALS AND METHODS: A retrospective study of patients with dental implants placed in posterior mandibular sites vertically augmented with intraoral onlay block bone grafts was carried out between 2005 and 2009 at the University of Valencia. The outcomes assessed at the 3-year follow-up visit were the peri-implant soft tissues (Plaque Index and Bleeding Index, probing depth, keratinized mucosa width, and recession), implant survival and success rates, marginal bone loss, and patient satisfaction...
January 2018: International Journal of Oral & Maxillofacial Implants
Yuchao Chen, Pan Mao, Antoine M Snijders, Daojing Wang
Cellular senescence plays an important role in organismal aging and age-related diseases. However, it is challenging to isolate low numbers of senescent cells from small volumes of biofluids for downstream analysis. Furthermore, there is no technology that could selectively remove senescent cells in a high-throughput manner. In this work, we developed a novel microfluidic chip platform, termed senescence chip, for ultrahigh-throughput isolation and removal of senescent cells. The core component of our senescence chip is a slanted and tunable 3D micropillar array with a variety of shutters in the vertical direction for rapid cell sieving, taking advantage of the characteristic cell size increase during cellular senescence...
January 16, 2018: Aging Cell
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
The activity and the distribution of osteogenic cells around octacalcium phosphate (OCP) granules combined with gelatin matrix (OCP/Gel) onlaid on rat calvaria were analyzed histomorphometrically and immunohistochemically during vertical bone augmentation under mechanical or non-mechanical environment until 8 weeks. OCP/Gel disk was placed in subperiosteal pocket on the calvaria with or without polytetrafluoroethylene (PTFE) support. The latter is a non-mechanical stress model to alleviate the mechanical stress from the subcutaneous tissues...
January 9, 2018: Journal of Biomedical Materials Research. Part A
R J de Groot, M A E M Oomens, T Forouzanfar, E A J M Schulten
INTRODUCTION: Long-standing loss of natural teeth in the mandible can lead to severe jaw atrophy and even mandibular fracture. There is no consensus on the best preprosthetic surgical treatment to reconstruct the atrophic edentulous mandible. The purpose of this review is to provide an overview of the existing literature and to give an evidence-based recommendation for bone grafting and future research. MATERIALS AND METHODS: This systematic review was conducted according to the PRISMA statement...
January 4, 2018: Journal of Oral Rehabilitation
Leonardo Ciocca, Giuseppe Lizio, Paolo Baldissara, Alessandro Sambuco, Roberto Scotti, Giuseppe Corinadesi
This study evaluated the outcomes of CAD-CAM customized titanium mesh used for prosthetically guided bone augmentation related to the occlusion driven implant position; to the vertical bone volume gain of mandible and maxilla; and to complications, like mesh exposure.. Nine patients scheduled for bone augmentation of atrophic sites were treated with custom titanium mesh and particulate bone grafts with autologous bone and anorganic bovine bone in a 1:1 ratio prior to implant surgery. The bone volume needed to augment was virtually projected based on implants position, width and length, and the mesh design was programmed for the necessary retaining screws...
January 5, 2018: Journal of Oral Implantology
Xi Jiang, Yu Zhang, Ping Di, Ye Lin
BACKGROUND: Guided bone regeneration (GBR) is currently the most widely used technique to reconstruct localized peri-implant bone defects. OBJECTIVES: To evaluate hard tissue volume stability during the healing stage of GBR with particulate bone graft and resorbable collagen membrane. MATERIALS AND METHODS: Twenty-eight patients who were missing a single maxillary incisor and required implant placement combined with GBR were randomly assigned to 2 groups: submerged (n = 14) and transmucosal (n = 14) healing groups...
February 2018: Clinical Implant Dentistry and related Research
Jésica Zuchuat, Marcelo Berli, Ysaí Maldonado, Oscar Decco
Cr-Co-Mo (ASTM F75) alloy has been used in the medical environment, but its use as a rigid barrier membrane for supporting bone augmentation therapies has not been extensively investigated. In the present study, Cr-Co-Mo membranes of different heights were placed in New Zealand white, male rabbit tibiae to assess the quality and volume of new bone formation, without the use of additional factors. Animals were euthanized at 20, 30, 40, and 60 days. Bone formation was observed in all of the cases, although the tibiae implanted with the standard membranes reached an augmentation of bone volume that agreed with the density values over the timecourse...
December 26, 2017: Journal of Functional Biomaterials
Jose M Reuss, Joan Pi-Anfruns, Peter K Moy
PURPOSE: The aim of this study was to assess the clinical effectiveness of alveolar distraction osteogenesis (ADO) versus recombinant human bone morphogenetic protein-2 (rh-BMP-2) for vertical ridge augmentation. Few data have been published on vertical bone regeneration using rh-BMP-2. MATERIALS AND METHODS: The authors implemented a retrospective cohort study and enrolled a sample composed of patients with deficient alveolar vertical bone height. The primary predictor variable was vertical augmentation with BMP-2 and a titanium mesh or ADO...
November 29, 2017: Journal of Oral and Maxillofacial Surgery
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