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Bone augmentation

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https://www.readbyqxmd.com/read/27906068/novel-use-of-cranial-epidural-space-in-rabbits-as-an-animal-model-to-investigate-bone-volume-augmentation-potential-of-different-bone-graft-substitutes
#1
Ivan Valdivia-Gandur, Wilfried Engelke, Víctor Beltrán, Eduardo Borie, Ramón Fuentes, María Cristina Manzanares-Céspedes
BACKGROUND: The success of bone augmentation to a major degree depends on the biomechanics and biological conditions of the surrounding tissues. Therefore, an animal model is needed providing anatomical sites with similar mechanical pressures for comparing its influence on different biomaterials for bone regeneration. The present report describes the new bone formation associated to biomaterial in a bursa created in the epidural space, between dura mater and cranial calvaria, under the constant pressure of cerebrospinal fluid...
December 1, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27904933/-metastatic-disease-in-long-bones-review-of-surgical-treatment-options
#2
Franz Liska, Philipp Schmitz, Norbert Harrasser, Peter Prodinger, Hans Rechl, Rüdiger von Eisenhart-Rothe
Surgery in metastatic bone disease is currently the most frequent type of surgery in orthopedic oncology. Improved survival rates and an increasing incidence of bone metastasis have led to an increase in complications caused by metastatic disease, such as pathological fractures or hardware failure after operative treatment. Although surgery of metastatic lesions remains a palliative therapy concept, because of sufficient therapy for the primary carcinomas, tumor-specific-oriented follow-up protocols and a variation in the prognosis for the individual entities, an individually adapted treatment strategy is necessary...
November 30, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27904730/intramedullary-nailing-for-pathological-fractures-of-the-proximal-humerus
#3
Eun-Seok Choi, Ilkyu Han, Hwan Seong Cho, In Woong Park, Jong Woong Park, Han-Soo Kim
BACKGROUND: Endoprosthetic reconstruction is widely applied for pathological fractures of the proximal humerus; however, functional impairment is usually unsatisfactory. The aims of the current study are to evaluate the reliability of interlocking intramedullary (IM) nailing with cement augmentation as a fixation method in proximal humeral lesions and to assess functional outcomes. METHODS: We reviewed 32 patients with pathological fractures of the proximal humerus who underwent interlocking IM nailing and cement augmentation...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27901312/female-white-footed-mice-peromyscus-leucopus-trade-off-offspring-skeletal-quality-for-self-maintenance-when-dietary-calcium-intake-is-low
#4
Christina M Schmidt, Wendy R Hood
During gestation and lactation in mammals, calcium and other minerals are transferred from female to offspring to support skeletal ossification. To meet mineral requirements, females commonly mobilize mineral from their own skeleton to augment dietary intake. Because the fitness costs of bone loss are expected to limit the amount of endogenous mineral that females transfer to their young, the amount of mineral allocated to offspring is predicted to be influenced by the availability of mineral in the female's diet...
November 30, 2016: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
https://www.readbyqxmd.com/read/27900710/customized-tantalum-augmented-reverse-shoulder-arthroplasty-for-glenoid-bone-defect-and-excessive-medialization-description-of-the-technique
#5
Nicola Ivaldo, Tony Mangano, Giovanni Caione, Mario Rossoni, Angelo Ligas
BACKGROUND: Glenoid bone defect and excessive medialization could represent challenging issues during reverse shoulder arthroplasty, especially in the setting of revision surgery. Although a solution is offered by the Boileau's BIO-RSA technique in primary cases, only autologous iliac crest bone graft and homologous graft from bone banks are available for revision surgeries, with known disadvantages and risk of graft resorption and implant failure. MATERIALS AND METHODS: We describe in this work a new technique based on a customized porous tantalum device to be used in salvage situations, aimed at lateralization of the glenoid component of a reverse shoulder arthroplasty...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27900098/clinical-effects-of-three-surgical-approaches-for-a-giant-cell-tumor-of-the-distal-radius-and-ulna
#6
Jing Zhang, Yi Li, Dongqi Li, Junfeng Xia, Su Li, Shunling Yu, Yedan Liao, Xiaojuan Li, Huilin Li, Zuozhang Yang
The aim of the present study was to assess the curative effects of three surgical approaches for a giant cell tumor (GCT) of the distal radius and ulna. A total of 27 patients with GCT on distal radius and ulnas (7 and 20, respectively), confirmed by biopsy, were treated with individualized treatment regimens, according to the Campanacci's grade system: i) Curettage plus inactivated tumor bed and allogeneic bone graft/bone cement augmentation for Campanacci's grade I GCT of the distal radius and ulna (Group A); ii) simple en bloc resection for Campanacci's grade II and III GCT of the distal ulna (Group B); iii) en bloc resection and reconstruction with non-vascularized fibular autograft/allogeneic bone graft for Campanacci's II and III GCT of the distal radius (Group C)...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896935/sandcastle-worm-inspired-blood-resistant-bone-graft-binder-using-a-sticky-mussel-protein-for-augmented-in-vivo-bone-regeneration
#7
Hyo Jeong Kim, Bong-Hyuk Choi, Sang Ho Jun, Hyung Joon Cha
Xenogenic bone substitutes are commonly used during orthopedic reconstructive procedures to assist bone regeneration. However, huge amounts of blood accompanied with massive bone loss usually increase the difficulty of placing the xenograft into the bony defect. Additionally, the lack of an organic matrix leads to a decrease in the mechanical strength of the bone-grafted site. For effective bone grafting, this study aims at developing a mussel adhesion-employed bone graft binder with great blood-resistance and enhanced mechanical properties...
November 29, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27896212/effect-of-slow-forced-eruption-on-the-vertical-levels-of-the-interproximal-bone-and-papilla-and-the-width-of-the-alveolar-ridge
#8
Eun-Young Kwon, Ju-Youn Lee, Jeomil Choi
OBJECTIVE: Forced eruption has been proposed for the reconstruction of deficient bone and soft tissue. The aim of this study was to examine the changes in the alveolar ridge width and the vertical levels of the interproximal bone and papilla following forced eruption. METHODS: Patients whose hopeless maxillary anterior teeth were expected to undergo severe bone resorption and soft tissue recession upon extraction were recruited. In addition, patients whose maxillary anterior teeth required forced eruption for restoration due to tooth fracture or dental caries were included...
November 2016: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/27895621/immune-modulatory-effects-of-human-chorionic-gonadotropin-on-dendritic-cells-supporting-fetal-survival-in-murine-pregnancy
#9
Dominique Dauven, Stefanie Ehrentraut, Stefanie Langwisch, Ana Claudia Zenclussen, Anne Schumacher
Dendritic cells (DCs) are critically involved in the determination of immunity vs. tolerance. Hence, DCs are key regulators of immune responses either favoring or disfavoring fetal survival. Several factors were proposed to modulate DC phenotype and function during pregnancy. Here, we studied whether the pregnancy hormone human chorionic gonadotropin (hCG) is involved in DC regulation. In vitro, bone marrow-derived DCs (BMDCs) were stimulated in the presence or absence of urine-purified or recombinant hCG (rhCG) preparations...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27893636/facial-contouring-by-targeted-restoration-of-facial-fat-compartment-volume-the-mid-face
#10
Wenjin Wang, Yun Xie, Ru-Lin Huang, Jia Zhou, Herrler Tanja, Peijuan Zhao, Chen Cheng, Sizheng Zhou, Lee L Q Pu, Qingfeng Li
BACKGROUND: Recent anatomical findings have suggested that facial fat distribution is complex and changes with age. Here, we developed a grafting technique based on the physiological distribution and volume changes of facial fat compartments to achieve a youthful and natural-looking face. METHODS: Forty cadaveric hemifaces were used for the dissection of fat compartments and neurovascular structures in the mid-face area. Seventy-eight patients were treated for cheek atrophy using our targeted restoration of mid-face fat compartment volume...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27893512/flap-designs-for-flap-advancement-during-implant-therapy-a-systematic-review
#11
Alexandra B Plonka, Rachel A Sheridan, Hom-Lay Wang
PURPOSE: Guided bone regeneration (GBR) procedures allow ridge augmentation before or at time of implant placement. GBR outcomes rely on primary passive tension-free wound closure, which may be achieved by a variety of flap designs and surgical procedures. A comprehensive literature review of flap design and management is provided, including material types, incision design, reflection, releasing, and suturing techniques. MATERIALS AND METHODS: Two reviewers completed a literature search using the PubMed database and a manual search of relevant journals...
November 23, 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27893426/sublethal-exposure-to-alpha-radiation-223ra-dichloride-enhances-various-carcinomas-sensitivity-to-lysis-by-antigen-specific-cytotoxic-t-lymphocytes-through-calreticulin-mediated-immunogenic-modulation
#12
Anthony S Malamas, Sofia R Gameiro, Karin M Knudson, James W Hodge
Radium-223 dichloride (Xofigo®; 223Ra) is an alpha-emitting radiopharmaceutical FDA-approved for the treatment of bone metastases in patients with advanced castration-resistant prostate cancer. It is also being examined clinically in patients with breast and lung carcinoma and patients with multiple myeloma. As with other forms of radiation, the aim of 223Ra is to reduce tumor burden by directly killing tumor cells. External beam (photon) and proton radiation have been shown to augment tumor sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes (CTLs)...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27891670/biomechanical-behavior-of-novel-composite-pmma-cap-bone-cements-in-an-anatomically-accurate-cadaveric-vertebroplasty-model
#13
Shant Aghyarian, Xiaobang Hu, Ram Haddas, Isador H Lieberman, Victor Kosmopoulos, Harry K W Kim, Danieli C Rodrigues
Vertebral compression fractures are caused by many factors including trauma and osteoporosis. Osteoporosis induced fractures are a result of loss in bone mass and quality that weaken the vertebral body. Vertebroplasty and kyphoplasty, involving cement augmentation of fractured vertebrae, show promise in restoring vertebral mechanical properties. Some complications however, are reported due to the performance characteristics of commercially available bone cements. In this study, the biomechanical performance characteristics of two novel composite (PMMA-CaP) bone cements were studied using an anatomically accurate human cadaveric vertebroplasty model...
November 27, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27891557/exogenous-expression-of-nt-3-and-trkc-genes-in-bone-marrow-stromal-cells-elevated-the-survival-rate-of-the-cells-in-the-course-of-neural-differentiation
#14
Houri Edalat, Zahra Hajebrahimi, Vahid Pirhajati, Mahmoud Tavallaei, Mansoureh Movahedin, Seyed Javad Mowla
Bone marrow stromal cells (BMSCs) are attractive cellular sources for cell therapy of many diseases, specifically neurodegenerative ones. The potential capability of BMSCs could be further augmented by enhancing their neuroprotective property, differentiation potential, and survival rate subsequent to transplantation. Therefore, a concurrent upregulation of neurotrophin-3 (NT-3) and its high affinity receptor, tyrosin kinase C (TrkC), was utilized in our study. BMSCs were cotransfected with pDsRed1-N1-NT-3 and pCMX-TrkC plasmids before induction of neural differentiation...
November 28, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27891316/histologic-and-histomorphometric-evaluation-of-two-grafting-materials-cenobone-and-itb-mba-in-open-sinus-lift-surgery
#15
Babak Amoian, Maryam Seyedmajidi, Hamidreza Safipor, Sediqe Ebrahimipour
AIMS AND OBJECTIVES: Alveolar ridge reduction caused after tooth extraction can be minimized through ridge preservation and application of graft materials. The aim of this study was to compare the histologic and histomorphometric aspects of bone particulated allografts, Cenobone and ITB-MBA, in the reconstruction of vertical alveolar ridge after maxillary sinus augmentation. MATERIALS AND METHODS: This clinical trial was performed among 20 patients. The participants were randomly divided into two groups of 10 participants...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27890229/maxillofacial-defects-and-the-use-of-growth-factors
#16
REVIEW
Alan S Herford, Meagan Miller, Fabrizio Signorino
The development and increase in knowledge of the benefits and applications of growth factors in craniofacial reconstruction adds a novel tool in the reconstructive surgeon's armamentarium. The use of growth factors varies according to presentation. Growth factors help to promote healing, angiogenesis, and formation of bone of improved quality and quantity. Growth factors used with stem cells and scaffolds provide a solution or alternative to discomfort created by donor autograft sites. The application and results of these growth factors are displayed in various examples of maxillofacial defects in this article, including reconstruction of a premaxillary cleft and of maxillary augmentation...
February 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/27888757/bmp4-id2-signaling-pathway-is-a-novel-therapeutic-target-for-late-outgrowth-endothelial-progenitor-cell-mediated-endothelial-injury-repair
#17
Wen-Hao Xia, Long Chen, Jian-Wen Liang, Xiao-Yu Zhang, Chen Su, Xinzhu Tong, Jiang He, Yan Li, Zheng Cao, Xiu-Fang Lin, Jun Tao
BACKGROUND: Endothelial progenitor cells (EPCs) play a pivotal role in endothelial repair following artery injury, however, the molecular mechanism of late outgrowth EPCs (LEPCs) in endothelial repair remained to be studied. Bone morphogenetic protein 4 (BMP4) is involved in vascular injury-mediated mobilization and homing of LEPCs. Here, we investigated the influence of BMP4-modified signaling pathway in LEPC-related endothelial repair of human and underlying molecular mechanism. METHODS AND RESULTS: In vitro, after a 28day culture, human LEPCs were pretreated with different concentrations of recombinant BMP4 (0, 10, 50, or 100ng/mL), which markedly augmented the migration and adhesion in vitro and demonstrated a significantly accelerated in vivo endothelial repair capacity of human LEPCs after transplantation into nude mice with carotid artery denudation injury...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27887876/an-accuracy-study-of-computer-planned-implant-placement-in-the-augmented-maxilla-using-osteosynthesis-screws
#18
L M Verhamme, G J Meijer, A Soehardi, S J Bergé, T Xi, T J J Maal
Previous research on the accuracy of flapless implant placement of virtually planned implants in the augmented maxilla revealed unfavourable discrepancies between implant planning and placement. By using the osteosynthesis screws placed during the augmentation procedure, the surgical template could be optimally stabilized. The purpose of this study was to validate this method by evaluating its clinically relevant accuracy. Twelve consecutive fully edentulous patients with extreme resorption of the maxilla were treated with a bone augmentation procedure...
November 22, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27887871/radiographic-results-of-augmented-all-polyethylene-glenoids-in-the-presence-of-posterior-glenoid-bone-loss-during-total-shoulder-arthroplasty
#19
Scott P Stephens, Edwin E Spencer, Michael A Wirth
BACKGROUND: Chronic osteoarthritis can result in glenohumeral subluxation and loss of posterior glenoid bone. This can alter normal glenohumeral biomechanics and affect the stress placed on the glenoid implant after total shoulder arthroplasty. This study evaluated the clinical and radiographic results of an augmented all-polyethylene glenoid for the treatment of glenoid osteoarthritis in the presence of posterior glenoid bone loss and determined whether any failures or complications occurred with short-term follow-up...
November 22, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27887870/involvement-of-indian-hedgehog-signaling-in-mesenchymal-stem-cell-augmented-rotator-cuff-tendon-repair-in-an-athymic-rat-model
#20
Jian-Chun Zong, Michael J Mosca, Ryan M Degen, Amir Lebaschi, Camila Carballo, Andrew Carbone, Guang-Ting Cong, Liang Ying, Xiang-Hua Deng, Scott A Rodeo
BACKGROUND: Bone marrow aspirate has been used in recent years to augment tendon-to-bone healing, including in rotator cuff repair. However, the healing mechanism in cell-based therapy has not been elucidated in detail. METHODS: Sixteen athymic nude rats were randomly allocated to 2 groups: experimental (human mesenchymal stem cells in fibrin glue carrier) and control (fibrin glue only). Animals were sacrificed at 2 and 4 weeks. Immunohistochemical staining was performed to evaluate Indian hedgehog (Ihh) signaling and SOX9 signaling in the healing enthesis...
November 22, 2016: Journal of Shoulder and Elbow Surgery
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