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Bone augmentation

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https://www.readbyqxmd.com/read/29332499/examination-of-an-in-vitro-methodology-to-evaluate-the-biomechanical-performance-of-nucleus-augmentation-in-axial-compression
#1
Sebastien Nf Sikora, Danielle E Miles, Sami Tarsuslugil, Marlène Mengoni, Ruth K Wilcox
Intervertebral disc degeneration is one of the leading causes of back pain, but treatment options remain limited. Recently, there have been advances in the development of biomaterials for nucleus augmentation; however, the testing of such materials preclinically has proved challenging. The aim of this study was to develop methods for fabricating and testing bone-disc-bone specimens in vitro for examining the performance of nucleus augmentation procedures. Control, nucleotomy and treated intervertebral disc specimens were fabricated and tested under static load...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29330392/haploidentical-hematopoietic-sct-using-helical-tomotherapy-for-total-body-irradiation-and-targeted-dose-boost-in-patients-with-high-risk-refractory-acute-lymphoblastic-leukemia
#2
Zujun Jiang, Junsong Jia, Chunyan Yue, Yan Pang, Zenghui Liu, Ling Ouyang, Hongbo Li, Jinjian Zhang, Ting Wen, Jing Li, Zhiqiang Li, Yan Wang, Yang Xiao, Haowen Xiao
A novel conditioning regimen using helical tomotherapy (HT) was developed to deliver 10 Gy for total body irradiation (TBI) and simultaneously augment dose to 12 Gy for targeted dose boost to total marrow, central nervous system leukemia, and extramedullary disease sites in patients with high-risk or relapsed/refractory acute lymphoblastic leukemia (ALL) receiving haploidentical allogeneic hematopoietic stem cell transplantation (allo-HSCT). Fourteen patients were included, eight of these patients were in first complete remission (CR1), one was in CR2, one had a partial response and four patients had refractory disease at transplantation...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29327379/influence-of-varying-stem-and-metaphyseal-sleeve-size-on-the-primary-stability-of-cementless-revision-tibial-trays-used-to-reconstruct-aori-iia-defects-a-simulation-study
#3
Maged Awadalla, Rami M A Al-Dirini, Dermot O'Rourke, Lucian Bogdan Solomon, Mark Heldreth, Mark Taylor
Traditionally, diaphyseal stems have been utilized to augment the stability of revision total knee replacement (rTKR) implants. More recently metaphyseal augments, such as sleeves, have been introduced to further augment component fixation. The effect of augments such as stems and sleeves have on the primary stability of a rTKR implant is poorly understood, however it has important implications on the complexity, costs and survivorship of the procedure. Finite element analysis was used to investigate the primary stability and strain distribution of various size stems and sleeves used in conjunction with a cementless revision tibial tray...
January 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29325202/interfacial-mineral-fusion-and-tubule-entanglement-as-a-means-to-harden-a-bone-augmentation-material
#4
Erik A B Hughes, Sophie C Cox, Megan E Cooke, Owen G Davies, Richard L Williams, Thomas J Hall, Liam M Grover
A new bone augmenting material is reported, which is formed from calcium-loaded hydrogel-based spheres. On immersion of these spheres in a physiological medium, they become surrounded with a sheath of precipitate, which ruptures due to a build-up in osmotic pressure. This results in the formation of mineral tubes that protrude from the sphere surface. When brought into close contact with one another, these spheres become fused through the entanglement and subsequent interstitial mineralization of the mineral tubules...
January 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29323266/aif-loss-deregulates-hematopoiesis-and-reveals-different-adaptive-metabolic-responses-in-bone-marrow-cells-and-thymocytes
#5
Lauriane Cabon, Audrey Bertaux, Marie-Noëlle Brunelle-Navas, Ivan Nemazanyy, Laurianne Scourzic, Laure Delavallée, Laura Vela, Mathieu Baritaud, Sandrine Bouchet, Cécile Lopez, Vu Quang Van, Kevin Garbin, Danielle Chateau, Françoise Gilard, Marika Sarfati, Thomas Mercher, Olivier A Bernard, Santos A Susin
Mitochondrial metabolism is a tightly regulated process that plays a central role throughout the lifespan of hematopoietic cells. Herein, we analyze the consequences of the mitochondrial oxidative phosphorylation (OXPHOS)/metabolism disorder associated with the cell-specific hematopoietic ablation of apoptosis-inducing factor (AIF). AIF-null (AIF-/Y ) mice developed pancytopenia that was associated with hypocellular bone marrow (BM) and thymus atrophy. Although myeloid cells were relatively spared, the B-cell and erythroid lineages were altered with increased frequencies of precursor B cells, pro-erythroblasts I, and basophilic erythroblasts II...
January 11, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29323045/does-vitamin-c-have-the-ability-to-augment-the-therapeutic-effect-of-bone-marrow-derived-mesenchymal-stem-cells-on-spinal-cord-injury
#6
Nesrine Salem, Mohamed Y Salem, Mohammed M Elmaghrabi, Moataz A Elawady, Mona A Elawady, Dina Sabry, Ashraf Shamaa, Abdel-Haleem H Elkasapy, Noha Ibrhim, Azza Elamir
Methylprednisolone (MP) is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury (SCI). Vitamin C (VC) is a natural water-soluble antioxidant that exerts neuroprotective effects through eliminating free radical damage to nerve cells. Bone marrow mesenchymal stem cells (BMMSCs), as multipotent stem cells, are promising candidates in SCI repair. To evaluate the therapeutic effects of MP, VC and BMMSCs on traumatic SCI, 80 adult male rats were randomly divided into seven groups: control, SCI (SCI induction by weight-drop method), MP (SCI induction, followed by administration of 30 mg/kg MP via the tail vein, once every other 6 hours, for five times), VC (SCI induction, followed by intraperitoneal administration of 100 mg/kg VC once a day, for 28 days), MP + VC (SCI induction, followed by administration of MP and VC as the former), BMMSCs (SCI induction, followed by injection of 3 × 106 BMMSCs at the injury site), and BMMSCs + VC (SCI induction, followed by BMMSCs injection and VC administration as the former)...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29322970/minimally-invasive-transforaminal-lumbar-interbody-fusion-using-bone-cement-augmented-pedicle-screws-for-lumbar-spondylolisthesis-in-patients-with-osteoporosis-case-series-and-review-of-literature
#7
Venkata Ramesh Chandra Vemula, Bodapati Chandramowliswara Prasad, M A Jagadeesh, Jayachandar Vuttarkar, Sanjeev Kumar Akula
BACKGROUND: Instrumentation in patients with osteoporosis is challenging. Bone cement-augmented fenestrated pedicle screw fixation is a new procedure for fixation in the osteoporotic bone; and, applying minimally invasive techniques to the above is a challenging and novel concept. AIMS: To evaluate the clinical and radiological outcome of minimally invasive spine surgery transforaminal lumbar interbody fusion (MIS-TLIF) in patients with spondylolisthesis and poor bone quality, performed with rigid instrumentation using bone cement [poly(methylmethacrylate)]-augmented fenestrated pedicle screws...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29321277/intrathymic-deletion-of-il-7-reveals-a-contribution-of-the-bone-marrow-to-thymic-rebound-induced-by-androgen-blockade
#8
Pedro M Rodrigues, Ana R Ribeiro, Nicolas Serafini, Catarina Meireles, James P Di Santo, Nuno L Alves
Despite the well-documented effect of castration in thymic regeneration, the singular contribution of the bone marrow (BM) versus the thymus to this process remains unclear. The chief role of IL-7 in pre- and intrathymic stages of T lymphopoiesis led us to investigate the impact of disrupting this cytokine during thymic rebound induced by androgen blockade. We found that castration promoted thymopoiesis in young and aged wild-type mice. In contrast, only young germline IL-7-deficient (Il7-/- ) mice consistently augmented thymopoiesis after castration...
January 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29318899/influence-of-transmucosal-height-in-abutments-of-single-and-multiple-implant-supported-prostheses-a-non-linear-three-dimensional-finite-element-analysis
#9
Eduardo Borie, Eduardo Leal, Iara Augusta Orsi, Carlos Salamanca, Fernando José Dias, Benjamin Weber
The aim of this study was to analyze the influence of three different transmucosal heights of the abutments in single and multiple implant-supported prostheses through the finite element method. External hexagon implants, MicroUnit, and EsthetiCone abutments were scanned and placed in an edentulous maxillary model obtained from a tomography database. The simulations were divided into two groups: (1) one implant with 3.75 × 10 mm placed in the upper central incisor, simulating a single implant-supported fixed prosthesis with an EsthetiCone abutment; and (2) two implants with 3...
January 10, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29318175/trends-in-shoulder-stabilization-techniques-used-in-the-united-states-based-on-a-large-private-payer-database
#10
Andrew J Riff, Rachel M Frank, Shelby Sumner, Nicole Friel, Bernard R Bach, Nikhil N Verma, Anthony A Romeo
Background: Arthroscopic stabilization is the most broadly used surgical procedure in the United States for management of recurrent shoulder instability. Latarjet coracoid transfer has been considered a salvage surgical procedure for failed arthroscopic repairs or cases of significant glenoid bone loss; however, with recent literature suggesting reduced risk of recurrent instability with Latarjet, several surgeons have advocated its broader utilization as a primary operation for treatment of shoulder instability...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317260/growth-factor-delivery-strategies-for-rotator-cuff-repair-and-regeneration
#11
Anupama Prabhath, Varadraj N Vernekar, Enid Sanchez, Cato T Laurencin
The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of surgical repair such as autografts, allografts, and xenografts are confounded by donor site morbidity, immunogenicity, and disease transmission, respectively. In contrast, these risks may be alleviated via growth factor therapy, which can actively influence the healing environment to promote functional repair...
January 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29316380/implant-insertion-into-an-augmented-bone-region-using-the-canine-mandible-augmented-by-the-casing-method
#12
Wataru Ono, Kiichi Maruyama, Makoto Ogiso, Seiji Mineno, Yuichi Izumi
The purpose of this study was to examine the efficacy of bone augmentation using the "Casing Method", which enables large-scale osteogenesis, and the feasibility of using the augmented bone in dental implants. Three Beagle dogs were used. After tooth extraction, a polyethylene terephthalate case (20 mm × 5 mm × 10 mm) was placed on the buccal surface of the mandible. A mixture of hydroxyapatite and beta-tricalcium phosphate (volume ratio=1:1) was infiltrated into a suspension of autologous superfine bone powder and plasma, and the resulting mixture was packed into the case...
January 6, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29316231/osteogenic-cellular-activity-around-onlaid-octacalcium-phosphate-gelatin-composite-onto-rat-calvaria
#13
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
The activity and the distribution of osteogenic cells around octacalcium phosphate (OCP) granules combined with gelatin matrix (OCP/Gel) onlaid on rat calvaria were analyzed histomorphometrically and immunohistochemically during vertical bone augmentation under mechanical or non-mechanical environment until 8 weeks. OCP/Gel disk was placed in subperiosteal pocket on the calvaria with or without polytetrafluoroethylene (PTFE) support. The latter is a non-mechanical stress model to alleviate the mechanical stress from the subcutaneous tissues...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316182/lateral-bone-augmentation-in-narrow-posterior-mandibles-description-of-a-novel-approach-and-analysis-of-results
#14
Ilan Beitlitum, Alon Sebaoun, Carlos E Nemcovsky, Shimshon Slutzkey
BACKGROUND: Combination of particulate grafts and collagen membranes is widely used for augmentation of bony defects for implant placement. Fixation of the barrier membrane may avoid complications due to unfavorable mechanical properties and poor stability leading to collapse of the augmented area. PURPOSE: To evaluate a new simplified method for resorbable collagen membrane fixation in lateral bone augmentation procedures in narrow posterior mandibles. MATERIALS AND METHODS: This retrospective study analyzed 16 procedures performed in 15 patients who followed lateral ridge augmentation procedures before implant placement in the posterior mandible...
January 8, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29314739/histological-changes-in-alveolar-bone-after-onlay-augmentation-using-the-casing-method
#15
Kiichi Maruyama, Wataru Ono, Makoto Ogiso, Seiji Mineno, Yuichi Izumi
OBJECTIVE: Numerous studies on alveolar bone augmentation have been reported. However, it remains challenging to obtain favorable new bone, especially for onlay bone augmentation. For successful onlay bone augmentation, it is necessary to use a graft material with high bone-forming activity and wound stabilization. We performed onlay bone augmentation on the buccal surface of mandibular alveolar bone in dogs, using a polyethylene terephthalate (PET) case (Casing method). The aim of this study was to histologically examine the feasibility of Casing method for external onlay bone augmentation...
January 3, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29314144/bone-augmentation-followed-by-implant-surgery-in-the-edentulous-mandible-a-systematic-review
#16
REVIEW
R J de Groot, M A E M Oomens, T Forouzanfar, E A J M Schulten
INTRODUCTION: Long-standing loss of natural teeth in the mandible can lead to severe jaw atrophy and even mandibular fracture. There is no consensus on the best preprosthetic surgical treatment to reconstruct the atrophic edentulous mandible. The purpose of this review is to provide an overview of the existing literature and to give an evidence-based recommendation for bone grafting and future research. MATERIALS AND METHODS: This systematic review was conducted according to the PRISMA statement...
January 4, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29311623/basal-p53-expression-is-indispensable-for-mesenchymal-stem-cell-integrity
#17
Siddaraju V Boregowda, Veena Krishnappa, Jacqueline Strivelli, Christopher L Haga, Cori N Booker, Donald G Phinney
Marrow-resident mesenchymal stem cells (MSCs) serve as a functional component of the perivascular niche that regulates hematopoiesis. They also represent the main source of bone formed in adult bone marrow, and their bifurcation to osteoblast and adipocyte lineages plays a key role in skeletal homeostasis and aging. Although the tumor suppressor p53 also functions in bone organogenesis, homeostasis, and neoplasia, its role in MSCs remains poorly described. Herein, we examined the normal physiological role of p53 in primary MSCs cultured under physiologic oxygen levels...
January 8, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29310917/mid-term-results-of-graft-augmentation-prosthesis-ii-cage-and-impacted-allograft-bone-in-revision-hip-arthroplasty
#18
Hazem A H Hosny, Ahmed El-Bakoury, Helmy Fekry, Jonathan Keenan
BACKGROUND: Several techniques have been described for management of severe acetabular bone defects during revision hip surgery including reconstructive cages. The purpose of this study is to analyze the survival and the mid-term clinical and radiological outcome using the Graft Augmentation Prosthesis (GAP II cage) (Stryker Orthopaedics, Mahwah, NJ) in addition to impaction grafting for acetabular defects in revision hip surgery. METHODS: This is a retrospective review of all patients who underwent acetabular revision hip replacement using GAP II cage and impaction bone grafting between 2009 and 2013 at our institution...
December 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29310362/wrapping-grafting-for-congenital-pseudarthrosis-of-the-tibia-a-preliminary-report
#19
An Yan, Hai-Bo Mei, Kun Liu, Jiang-Yan Wu, Jin Tang, Guang-Hui Zhu, Wei-Hua Ye
OBJECTIVE: Treatment of congenital pseudarthrosis of the tibia (CPT) remains a challenge. The autogenic iliac bone graft is important consistent of treatment for CPT. The purpose of this study was to investigate the role of wrapping autogenic iliac bone graft in improvement of the curing opportunities of CPT. METHODS: We combined Ilizarov fixator with intramedullary rodding of the tibia and wrapping autogenic iliac bone graft for treatment 51 cases of CPT between 2007 and 2010...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29304988/uncertainty-about-the-benefits-of-bone-augmentation-procedures-in-patients-receiving-immediate-implants
#20
Romina Brignardello-Petersen
No abstract text is available yet for this article.
December 29, 2017: Journal of the American Dental Association
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