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https://www.readbyqxmd.com/read/29042430/ideal-cardiovascular-health-and-incident-cardiovascular-disease-heterogeneity-across-event-subtypes-and-mediating-effect-of-blood-biomarkers-the-prime-study
#1
Bamba Gaye, Muriel Tafflet, Dominique Arveiler, Michèle Montaye, Aline Wagner, Jean-Bernard Ruidavets, Frank Kee, Alun Evans, Philippe Amouyel, Jean Ferrieres, Jean-Philippe Empana
BACKGROUND: The aim of this study was to investigate whether the association between baseline cardiovascular health (CVH) and incident cardiovascular disease differs according to coronary heart disease (CHD) and stroke subtypes, and to assess the mediating effect of inflammatory and hemostatic blood biomarkers. METHODS AND RESULTS: The association of ideal CVH with outcomes was derived in 9312 middle-aged men from Northern Ireland and France (whole cohort) in multivariable Cox proportional hazards regression analysis...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29040831/synergy-in-thrombin-graphene-sponge-for-improved-hemostatic-efficacy-and-facile-utilization
#2
Guofeng Li, Kecheng Quan, CongCong Xu, Bo Deng, Xing Wang
Composites are attractive for its potential synergistic effects that can result in high-performance, but the synergy depends on subtle design. In this study, a hemostatic composite, a thrombin/cross-linked graphene sponge (TCGS), was developed through a facile gradient composite strategy. The porous structure of the CGS assures that the thrombin is stably embedded in the TCGS, avoiding a burst release but maintaining its bioactivity. In the synergy between proper thrombin stimulation and the fast absorption of the sponge, TCGS exhibits outstanding hemostatic performance, ultrafast bleeding cessation, within 100s, which is superior to both CGS and equal amounts of native thrombin...
October 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29037192/retroperitoneal-ectopic-pregnancy-a-case-report-and-review-of-the-literature
#3
Man Yang, Lamu Cidan, Dan Zhang
BACKGROUND: Retroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy, with a total of less than 20 cases reported in the English literature. However, failure to recognize REP may result in severe consequences. CASE PRESENTATION: We report a case of 32-year-old woman with REP. She had amenorrhea, left lower abdominal pain, but no vaginal bleeding. Her urine human chorionic gonadotropin (HCG) test was positive and blood HCG level was 1880 m-international units per milliliter (mIU/mL)...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29035656/clinical-laboratory-and-hemostatic-findings-in-cats-with-naturally-occurring-sepsis
#4
Sigal Klainbart, Limor Agi, Tali Bdolah-Abram, Efrat Kelmer, Itamar Aroch
OBJECTIVE To characterize clinical and laboratory findings in cats with naturally occurring sepsis, emphasizing hemostasis-related findings, and evaluate these variables for associations with patient outcomes. DESIGN Prospective, observational, clinical study. ANIMALS 31 cats with sepsis and 33 healthy control cats. PROCEDURES Data collected included history; clinical signs; results of hematologic, serum biochemical, and hemostatic tests; diagnosis; and outcome (survival vs death during hospitalization or ≤ 30 days after hospital discharge)...
November 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29034218/deciphering-babesia-vector-interactions
#5
REVIEW
Sandra Antunes, Catarina Rosa, Joana Couto, Joana Ferrolho, Ana Domingos
Understanding host-pathogen-tick interactions remains a vitally important issue that might be better understood by basic research focused on each of the dyad interplays. Pathogens gain access to either the vector or host during tick feeding when ticks are confronted with strong hemostatic, inflammatory and immune responses. A prominent example of this is the Babesia spp.-tick-vertebrate host relationship. Babesia spp. are intraerythrocytic apicomplexan organisms spread worldwide, with a complex life cycle. The presence of transovarial transmission in almost all the Babesia species is the main difference between their life cycle and that of other piroplasmida...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29031658/randomized-controlled-pilot-study-of-the-preoperative-use-of-brimonidine-0-33-topical-gel-for-hemostasis-in-mohs-micrographic-surgery
#6
Edward Chen, Raj Ajay Patel, Young Jin Kwak, Conway C Huang
BACKGROUND: Brimonidine topical gel may be useful in cutaneous surgical procedures because of its vasoconstricting properties. OBJECTIVE: Assess the hemostatic effect of topically applied brimonidine in patients being treated with anticoagulants and undergoing Mohs micrographic surgery (MMS). METHODS: Subjects undergoing MMS were randomly assigned to the control (n = 10) or study arm (n = 14). Controls received standard-of-care MMS, whereas the study arm received the same and preoperative application of brimonidine...
October 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29029126/hyalomma-dromedarii-acari-ixodidae-salivary-gland-extract-inhibits-angiogenesis-and-exhibits-in-vitro-antitumor-effects
#7
Chaima Bensaoud, Zaineb Abdelkafi-Koubaa, Hazem Ben Mabrouk, Maram Morjen, Issam Hmila, Adel Rhim, Mohamed El Ayeb, Naziha Marrakchi, Ali Bouattour, Youmna M'ghirbi
Hard ticks (Acari: Ixodidae) are blood-sucking ectoparasites characterized by the extended period of their attachment to their host. To access their bloodmeal, ticks secrete saliva containing a range of molecules that target the host's inflammation, immune system, and hemostatic components. Some of these molecules reportedly possess antiangiogenic and antitumor properties. The present study describes our investigation, the first of its kind, of the antiangiogenic and antitumoral effects of the Hyalomma dromedarii Koch, 1844 (Acari: Ixodidae), salivary gland extract (SGE), which inhibited the adhesion and migration of Human Umbilical Vein Endothelial Cells (HUVECs) in a dose-dependent manner, as well as angiogenesis in the Chick Chorioallantoic Membrane model...
September 25, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29028293/a-large-case-series-on-surgical-outcomes-in-congenital-fxiii-deficiency-patients-in-iran
#8
Majid Naderi, Sezaneh Haghpanah, Ghasem Miri-Aliabad, Hakimeh Tavosi, Mehran Karimi
BACKGROUND: The lack of accepted standardized surgical guidelines leads to dependence on the treating physicians' and centers' experiences. AIM: Our aim is to evaluate the surgical outcomes on a large group of congenital FXIII deficiency (FXIIID) patients. METHODS: A case series study was conducted on congenital FXIIID patients in two major referral centers located in Iran from 2010 to 2016 prior to surgery. All patients were on prophylaxis using plasma factor XIII concentrate (10 U kg(-1) , every 28 days) except three patients...
October 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29026409/hemostasis-in-hypothyroidism-and-autoimmune-thyroid-disorders
#9
REVIEW
Arash Ordookhani, Kenneth D Burman
CONTEXT: There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders. EVIDENCE ACQUISITION: A comprehensive literature search was conducted employing MEDLINE database...
April 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29025669/preparation-and-evaluation-of-squid-ink-polysaccharide-chitosan-as-a-wound-healing-sponge
#10
Na Huang, Jiali Lin, Sidong Li, Yifeng Deng, Songzhi Kong, Pengzhi Hong, Ping Yang, Mingneng Liao, Zhang Hu
A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design-response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS)...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29020709/absorbaseal%C3%A2-vascular-closure-device-a-novel-device-for-hemostasis-following-interventional-peripheral-vascular-procedures
#11
Emily Benham, Koen Deloose, Joren Callaert, Marc Bosiers, Tiffany Cox, Amy Lincourt, B Todd Heniford
INTRODUCTION: Vascular closure devices (VCDs) are designed to achieve rapid hemostasis during percutaneous coronary and peripheral vascular procedures. Studies demonstrate that VCDs improve time to hemostasis (TTH) and time to ambulation (TTA) in comparison to standard manual compression. The available products, however, typically have 13-17 steps in their application, often require hemostatic collagen or other agents as part of the process, and can result in significant scarring at the puncture site that can impact future access...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29019594/allogeneic-mesenchymal-stem-cells-and-xenogenic-platelet-rich-plasma-associated-or-not-in-the-repair-of-bone-failures-in-rabbits-with-secondary-osteoporosis
#12
Mariá Andrade de Carvalho Rocha, Laís Meireles Costa Silva, Wellson Andrade de Oliveira, Dayseanny de Oliveira Bezerra, Gustavo Cardoso da Silva, Lucilene Dos Santos Silva, Brenda Lurian do Nascimento Medeiros, Sílvia de Araújo França Baêta, Maria Acelina Martins de Carvalho, Napoleão Martins Argôlo
PURPOSE: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. METHODS: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic platelet-rich plasma and the association between both...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29019480/design-and-development-of-polysaccharide-hemostatic-materials-and-their-hemostatic-mechanism
#13
REVIEW
Xiao Yang, Wen Liu, Na Li, Mingshan Wang, Bin Liang, Ihsan Ullah, Agnaldo Luis Neve, Yakai Feng, Hao Chen, Changcan Shi
The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body's own coagulation process is not able to accomplish timely hemostasis without the assistance of hemostatic agents. For developing novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and the hemostasis mechanism of different materials. Among hemostatic materials, polysaccharides are naturally derived polymers having excellent biodegradable and biocompatible properties...
October 11, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29019069/pro-con-debate-valve-sparing-aortic-root-surgery-pro-reimplantation
#14
Ruggero De Paulis
The remodeling and the reimplantation procedures were described more than 25 years ago with the aim of sparing, otherwise normal aortic valve in the presence of a root aneurysm. Because of its ability to reconstruct the sinuses of Valsalva, the remodeling procedure was considered to be more physiological than the reimplantation. However, because the remodeling lacked annular stabilization, the long-term stability of the procedure was questioned. However, through the years, both procedures have been significantly improved, so that is now possible to perform a reimplantation procedure with neo-sinuses reconstruction or a remodeling procedure with annular stabilization...
October 10, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29017137/ovarian-vein-thrombosis-after-total-laparoscopic-hysterectomy-with-unilateral-adnexectomy-a-case-report
#15
Samer Nikolaos Al-Αchmar, Sofoklis Stavrou, Athanasios Protopapas, Peter Drakakis, Panagiota Siemou, Ioannis Chatzipapas
INTRODUCTION: Ovarian vein thrombosis is a rare but potentially serious complication after surgical and gynecologic procedures such as oophorectomy and hysterectomy. The association of this event with laparoscopic hysterectomy in particular, is very rare. Only two cases have been described so far. PRESENTATION OF CASE: We present a case of ovarian vein thrombosis after laparoscopic hysterectomy in a 40-year-old with deep endometriosis and multiple intramural uterine myomas...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28992806/in-vitro-and-in-vivo-evaluation-of-the-duck-s-feet-collagen-sponge-for-hemostatic-applications
#16
Ye Been Seo, Ok Joo Lee, Md Tipu Sultan, Jung Min Lee, Ye Ri Park, Yeung Kyu Yeon, Ji Seung Lee, Young Jin Lee, Soon Hee Kim, Chan Hum Park
Recently different hemostatic agents have been developed, but most of them are ineffective in severe bleeding and expensive or cause safety concerns. In this study, we fabricated duck's feet collagen-based porous sponges and investigated its use as a hemostatic agent. We determined the sponge's physical and biological characteristics and compared with Avitene via scanning electron microscope analysis, water-uptake abilities and porosity test, and cytotoxicity assay. The duck's feet collagen/silk sponge showed a larger interconnected porous structure compared to others sponges...
October 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28991571/wrist-arthroscopy-under-portal-site-local-anesthesia-without-tourniquet-and-sedation
#17
REVIEW
Siu-Cheong Jeffrey Justin Koo, Pak-Cheong Ho
We had developed the technique of portal site local anaesthesia (PSLA) for wrist arthroscopy. Two percent lidocaine with 1:200,000 epinephrine is injected through a 25G needle to various portal sites. The radiocarpal joint is then distended with saline injection and portal is created with transverse superficial skin incision followed by dilation with curved hemostat. The patient is neither sedated, nor under general or regional anaesthesia. Tourniquet is not routinely used. PSLA can achieve satisfactory comfort level in 88% of our 111 patients without any complication...
November 2017: Hand Clinics
https://www.readbyqxmd.com/read/28991109/patient-blood-management-in-pediatric-cardiac-surgery-a-review
#18
Jill M Cholette, David Faraoni, Susan M Goobie, Victor Ferraris, Nabil Hassan
Efforts to reduce blood product transfusions and adopt blood conservation strategies for infants and children undergoing cardiac surgical procedures are ongoing. Children typically receive red blood cell and coagulant blood products perioperatively for many reasons, including developmental alterations of their hemostatic system, and hemodilution and hypothermia with cardiopulmonary bypass that incites inflammation and coagulopathy and requires systemic anticoagulation. The complexity of their surgical procedures, complex cardiopulmonary interactions, and risk for inadequate oxygen delivery and postoperative bleeding further contribute to blood product utilization in this vulnerable population...
October 5, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28990448/evaluation-of-hemostatic-effect-of-polyelectrolyte-complex-based-dressings
#19
Manisha Buriuli, Wasupalli Geeta Kumari, Devendra Verma
The aim of this work was to develop a polyelectrolyte complex-based hemostatic dressing made from chitosan and polygalacturonic acid. Porous dressings were fabricated by ultrasonication of chitosan and alginate solutions followed by freeze-drying. Since chitosan has inherent hemostatic properties, and polygalacturonic acid is anti-inflammatory in nature, it was desired to combine these two polymers to develop an effective hemostatic dressing, which may also promote wound healing. Porous structure of the bandages was observed using field-emission scanning electron microscope...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28988575/alcohol-s-effects-on-the-cardiovascular-system
#20
Mariann R Piano
Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are outlined in this review. Although many behavioral, genetic, and biologic variants influence the interconnection between alcohol use and CV disease, dose and pattern of alcohol consumption seem to modulate this most. Low-to-moderate alcohol use may mitigate certain mechanisms such as risk and hemostatic factors affecting atherosclerosis and inflammation, pathophysiologic processes integral to most CV disease...
2017: Alcohol Research: Current Reviews
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