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https://www.readbyqxmd.com/read/29451778/rapid-forming-and-self-healing-agarose-based-hydrogels-for-tissue-adhesives-and-potential-wound-dressings
#1
Zhuo Zhang, Xiaolin Wang, Yitong Wang, Jingcheng Hao
To meet the progressive requirements of advanced engineering materials with superior physicochemical performances, self-healing and injectable hydrogels (AD hydrogels) based on agarose with pH-response were prepared through dynamic covalent Schiff-base linkages by simply mixing nontoxic agarose-ethylenediamine conjugate (AG-NH2) and dialdehyde-functionalized polyethylene glycol (DF-PEG) solutions. The self-healing and injectable capabilities of the hydrogels without any external stimulus are ascribed to dynamic covalent Schiff-base linkages between the aldehyde groups of DF-PEG and amine groups on AG-NH2 backbone...
February 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29449604/intravenous-synthetic-platelet-synthoplate-nanoconstructs-reduce-bleeding-and-improve-golden-hour-survival-in-a-porcine-model-of-traumatic-arterial-hemorrhage
#2
DaShawn A Hickman, Christa L Pawlowski, Andrew Shevitz, Norman F Luc, Ann Kim, Aditya Girish, Joyann Marks, Simi Ganjoo, Stephanie Huang, Edward Niedoba, Ujjal D S Sekhon, Michael Sun, Mitchell Dyer, Matthew D Neal, Vikram S Kashyap, Anirban Sen Gupta
Traumatic non-compressible hemorrhage is a leading cause of civilian and military mortality and its treatment requires massive transfusion of blood components, especially platelets. However, in austere civilian and battlefield locations, access to platelets is highly challenging due to limited supply and portability, high risk of bacterial contamination and short shelf-life. To resolve this, we have developed an I.V.-administrable 'synthetic platelet' nanoconstruct (SynthoPlate), that can mimic and amplify body's natural hemostatic mechanisms specifically at the bleeding site while maintaining systemic safety...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444563/recent-update-on-coagulation-management-and-hemostatic-therapies-in-liver-transplantation
#3
Ezeldeen Abuelkasem, Kenichi A Tanaka, Raymond M Planinsic
Liver transplantation is an ever-evolving field and understanding coagulation management and hemostatic therapies is essential for good outcomes. In this review, we discuss current monitoring tools available in the operating room and the hemostatic agents available to control hemostasis. Multifactorial coagulation defects are discussed and point-of care monitoring is reviewed to guide selection of hemostatic agents when indicated.
February 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29443862/red-tides-mass-casualty-and-whole-blood-at-sea-red-tides
#4
Benjamin T Miller, Andrew H Lin, Susan C Clark, Andrew P Cap, Joseph J Dubose
BACKGROUND: The U.S. Navy's casualty-receiving ships provide remote damage control resuscitation (RDCR) platforms to treat injured combatants deployed afloat and ashore. We report a significant mass casualty incident aboard the USS Bataan, and the most warm fresh whole blood (WFWB) transfused at sea for traumatic hemorrhagic shock since the Vietnam War. METHODS: Casualty-receiving ships have robust medical capabilities, including a frozen blood bank with packed red blood cells (pRBC) and fresh frozen plasma (FFP)...
February 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29441021/biology-of-platelet-purinergic-receptors-and-implications-for-platelet-heterogeneity
#5
REVIEW
Milka Koupenova, Katya Ravid
Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic plug, although this activation process becomes problematic in pathological settings of thrombosis. This review briefly outlines the roles and function of currently known platelet purinergic receptors (P1 and P2) in the setting of hemostasis and thrombosis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29439640/an-evaluation-of-hemostatic-abnormalities-in-patients-with-hemophilia-according-to-the-activated-partial-thromboplastin-time-waveform
#6
Haruna Katayama, Takeshi Matsumoto, Hideo Wada, Naoki Fujimoto, Junki Toyoda, Yasunori Abe, Kohshi Ohishi, Yoshiki Yamashita, Makoto Ikejiri, Koji Habe, Naoyuki Katayama
The usefulness of the waveform of activated partial thromboplastin time (APTT) in various diseases has been evaluated in recent years. The APTT waveform was examined in patients with hemophilia and patients positive for lupus anticoagulant (LA). The correlation with the FVIII activity was highest for the height of acceleration peak. The peak time of acceleration, velocity, and ½ fibrin formation, and the width of acceleration and velocity were significantly long and the height of acceleration was significantly low in patients with hemophilia...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29438209/an-unusual-complication-of-bone-wax-utilization
#7
Artur Fahradyan, Levonti Ohanisian, Michaela Tsuha, Matthew J Park, Jeffrey A Hammoudeh
Bone wax is a commonly used hemostatic agent with minimal complications. Some of the known complications include inflammation, granuloma formation, infection, and impaired osteogenesis. Several clinical reports of bone wax migration have also been reported. In this paper, the authors present a rare patient of bone wax migration intracranially in a 6-year-old patient who initially underwent craniotomy for the evacuation of subdural hematoma and repair of depressed skull fracture. The patient then underwent craniotomy scalp scar revision several months later...
February 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29437578/tissue-factor-an-essential-mediator-of-hemostasis-and-trigger-of-thrombosis
#8
REVIEW
Steven P Grover, Nigel Mackman
Tissue factor (TF) is the high-affinity receptor and cofactor for FVII/VIIa. The TF-FVIIa complex is the primary initiator of blood coagulation and plays an essential role in hemostasis. TF is expressed on perivascular and epithelial cells at organ and body surfaces where it forms a hemostatic barrier. TF also provides additional hemostatic protection to vital organs, such as the brain, lung, and heart. Under pathological conditions, TF can trigger both arterial and venous thrombosis. For instance, atherosclerosis plaques contain high levels of TF on macrophage foam cells and microvesicles that drives thrombus formation after plaque rupture...
February 8, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29437487/swim-exercise-inhibits-hemostatic-abnormalities-in-a-rat-model-of-obesity-and-insulin-resistance
#9
Mohammad Dallak, Ismaeel Bin-Jaliah, Hussein F Sakr, Bahjat Al-Ani, Mohamed A Haidara
BACKGROUND: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis. MATERIAL AND METHODS: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-'treated' rats started swim exercise training from the 11 th week until being sacrificed, on Week 15. RESULTS: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers...
February 13, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29433389/phytotherapeutic-activities-of-sanguisorba-officinalis-and-its-chemical-constituents-a-review
#10
Eungyeong Jang, Kyung-Soo Inn, Young Pyo Jang, Kyung-Tae Lee, Jang-Hoon Lee
Sanguisorba officinalis Linne (S. officinalis, Rosaceae) has been used as a medicinal plant for the treatment of burns, hematemesis, melena, intestinal infections, and dermatitis for a long time in China, Korea, and Japan. The therapeutic efficacy of this herb is intimately associated with its anti-oxidant, anti-inflammatory, antiviral, antifungal, hemostatic, and anticancer activities. Its root contains triterpenoid saponins (zigyuglycoside I: C[Formula: see text]H[Formula: see text]O[Formula: see text] and ziyuglycoside II: C[Formula: see text]H[Formula: see text]O8) and tannins (sanguiin H-6: C[Formula: see text]H[Formula: see text]O[Formula: see text])...
February 12, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29432043/prehospital-application-of-hemostatic-agents-in-iraq-and-afghanistan
#11
Steven G Schauer, Michael D April, Jason F Naylor, Joseph K Maddry, Allyson A Arana, Michael A Dubick, Andrew D Fisher, Cord W Cunningham, Anthony E Pusateri
INTRODUCTION: Hemorrhage is the leading cause of death on the battlefield. Development of chitosan- and kaolin-based hemostatic agents has improved hemorrhage control options. Sparse data exists on the use of these agents in the prehospital, combat setting. We describe recent use of these agents and compare patients receiving hemostatic to the baseline population. METHODS: We used a series of emergency department (ED) procedure codes to identify patients within the Department of Defense Trauma Registry (DODTR) from January 2007 to August 2016...
February 12, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29430670/the-effect-of-3-resuscitative-fluid-therapies-on-hemostasis-as-measured-by-rotational-thromboelastometry-in-dogs
#12
Sunita Seshia, M Casey Gaunt, Beverly A Kidney, Marion L Jackson
BACKGROUND: Evidence suggests that administration of intravenous fluids impairs hemostasis. Thromboelastometry (TEM) may provide a more sensitive measure of the fluid effects on hemostasis than traditional coagulation tests. OBJECTIVE: The study aim was to determine if resuscitative fluid therapy affects hemostasis, as measured by TEM. MATERIALS AND METHODS: Using a randomized crossover design, 6 healthy dogs were administered intravenous colloid, crystalloid, and hypertonic saline at therapeutic doses...
February 11, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29425720/nanoengineered-injectable-hydrogels-from-kappa-carrageenan-and-two-dimensional-nanosilicates-for-wound-healing-application
#13
Giriraj Lokhande, James K Carrow, Teena Thakur, Janet R Xavier, Madasamy Parani, Kayla J Bayless, Akhilesh K Gaharwar
We report injectable nanoengineered hemostats for enhanced wound healing and tissue regeneration. The nanoengineered system consists of the natural polysaccharide, κ-carrageenan (κCA), loaded with bioactive two-dimensional (2D) nanosilicates. Nanoengineered hydrogels showed shear-thinning characteristics and can be injected for a minimally invasive approach. The hydrogel can be physically crosslinked in presence of monovalent ions and result in mechanically strong hydrogels. By controlling the ratio between κCA and nanosilicates, compressive stiffness of nanoengineered hydrogels can be modulated between 20 to 200kPa...
February 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29424334/reactive-gliosis-mimicking-tumor-recurrence-a-case-series-documenting-mri-abnormalities-and-neuropathological-correlates
#14
Hugh Kearney, Jane Cryan, Alan Beausung, Seamus Looby, Francesca M Brett
The aim of this study is to identify, in our center, all cases of foreign-body reactions to hemostatic agents or other prostheses resulting in a radiological suspicion of tumor recurrence. We interrogated our internal database to identify all such cases and systematically evaluated the MRI brain scans of patients: (i) at the time of initial tumor diagnosis, (ii) postoperatively, (iii) and at the time of suspected tumor recurrence. In addition, we reviewed each patient's operative notes and reviewed the histology of all cases following a second surgical intervention...
February 9, 2018: Clinical Neuropathology
https://www.readbyqxmd.com/read/29420097/hemostatic-comparison-of-a-polysaccharide-powder-and-a-gelatin-powder
#15
Rahul K Singh, Bernhard Baumgartner, Jason R Mantei, Rhea N Parreno, Paul J Sanders, Kevin M Lewis, John J Barry
Purpose/Aim: Powdered hemostats have been widely adopted for their ease-of-use; however, their efficacy has been limited resulting in applications restricted to low-level bleeds. This study investigates the use of bovine-derived gelatin particles (BGP) as a standalone hemostatic powder and compare BGP to commercially available microporous polysaccharide hemospheres (MPH). MATERIALS AND METHODS: The powders were investigated for their hemostatic efficacy in a heparinized pre-clinical bleeding model limited to grade 1 and 2 bleeds on a validated intraoperative bleeding scale, which represents the accepted, clinical use of hemostatic powders...
February 8, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29415371/effectiveness-of-the-polysaccharide-hemostatic-powder-in-non-variceal-upper-gastrointestinal-bleeding-using-propensity-score-matching
#16
Jun Chul Park, Yeong Jin Kim, Eun Hye Kim, Jinae Lee, Hyun Su Yang, Eun Hwa Kim, Kyu Yeon Hahn, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
BACKGROUND AND AIM: Recently, the application of hemostatic powder to the bleeding site has been used to treat active upper gastrointestinal bleeding (UGIB). We aimed to assess the effectiveness of the polysaccharide hemostatic powder (PHP) in patients with non-variceal UGIB. METHODS: We reviewed prospectively collected 40 patients with UGIB treated with PHP therapy between April 2016 and January 2017 (PHP group) and 303 patients with UGIB treated with conventional therapy between April 2012 and October 2014 (conventional therapy group)...
February 7, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29413859/brain-damage-and-neurological-symptoms-induced-by-t-2-toxin-in-rat-brain
#17
Pu Guo, Aimei Liu, Deyu Huang, Qinghua Wu, Zainab Fatima, Yanfei Tao, Guyue Cheng, Xu Wang, Zonghui Yuan
T-2 toxin, a trichothecene mycotoxin, is a common contaminant in food and animal feed, and is also present in processed cereal products. The most common route of T-2 toxin exposure in humans is through dietary ingestion. The cytotoxic effects of T-2 toxin include modifications to feeding behavior, nervous disorders, cardiovascular alterations, immunosuppression, and hemostatic derangements. However, to date, effects on the central nervous system (CNS) have rarely been reported. In the present study, female Wistar rat were given a single dose of T-2 toxin at 2 mg/kg b...
January 27, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29412690/platelet-procoagulant-phenotype-is-modulated-by-a-p38-mk2-axis-regulating-rtn4-nogo-proximal-to-the-endoplasmic-reticulum-utility-of-pathway-analysis
#18
Özgün Babur, Anh T P Ngo, Rachel A Rigg, Jiaqing Pang, Zhoe T Rub, Ariana E Buchanan, Annachiara Mitrugno, Larry L David, Owen J T McCarty, Emek Demir, Joseph E Aslan
Upon encountering physiological cues associated with damaged or inflamed endothelium, blood platelets set forth intracellular responses to ultimately support hemostatic plug formation and vascular repair. To gain insights into the molecular events underlying platelet function, we used a combination of interactome, pathway analysis and other systems biology tools to analyze associations amongst proteins functionally modified by reversible phosphorylation upon platelet activation. While an interaction analysis mapped out a relative organization of intracellular mediators in platelet signaling, pathway analysis revealed directional signaling relations around protein kinase C (PKC) isoforms and mitogen activated protein kinases (MAPKs) associated with platelet cytoskeletal dynamics, inflammatory responses and hemostatic function...
February 7, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29411561/a-case-of-intraoperative-anaphylaxis-caused-by-bovine-derived-thrombin
#19
Hye Jung Park, Kyung Soo Suk, Jung Won Park
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29410404/a-microengineered-vascularized-bleeding-model-that-integrates-the-principal-components-of-hemostasis
#20
Yumiko Sakurai, Elaissa T Hardy, Byungwook Ahn, Reginald Tran, Meredith E Fay, Jordan C Ciciliano, Robert G Mannino, David R Myers, Yongzhi Qiu, Marcus A Carden, W Hunter Baldwin, Shannon L Meeks, Gary E Gilbert, Shawn M Jobe, Wilbur A Lam
Hemostasis encompasses an ensemble of interactions among platelets, coagulation factors, blood cells, endothelium, and hemodynamic forces, but current assays assess only isolated aspects of this complex process. Accordingly, here we develop a comprehensive in vitro mechanical injury bleeding model comprising an "endothelialized" microfluidic system coupled with a microengineered pneumatic valve that induces a vascular "injury". With perfusion of whole blood, hemostatic plug formation is visualized and "in vitro bleeding time" is measured...
February 6, 2018: Nature Communications
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