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https://www.readbyqxmd.com/read/28634646/the-role-of-robotics-in-the-invasive-management-of-bladder-cancer
#1
REVIEW
Pramit Khetrapal, Wei Shen Tan, Benjamin Lamb, Melanie Tan, Hilary Baker, James Thompson, Ashwin Sridhar, John D Kelly, Tim Briggs
Robot-assisted radical cystectomy (RARC) has been adopted widely in many centres, owed largely to the success of robot-assisted laparoscopic prostatectomy (RALP). It aims to replicate the oncological outcomes of open radical cystectomy (ORC), while providing a shorter recovery period. Despite this, previous RCTs have failed to show a benefit for RARC over ORC. These trials have compared extracorporeal RARC (eRARC) with ORC, which requires a further incision to mobilise the bowel for urinary reconstruction with an open technique...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28628910/the-efficacy-of-trimodal-chemoradiotherapy-with-cisplatin-as-a-bladder-preserving-strategy-for-the-treatment-of-muscle-invasive-bladder-cancer
#2
Kazuhiro Nagao, Takahiko Hara, Jun Nishijima, Kosuke Shimizu, Nakanori Fujii, Keita Kobayashi, Yoshihisa Kawai, Ryo Inoue, Yoshiaki Yamamoto, Hiroaki Matsumoto, Hideyasu Matsuyama
INTRODUCTION: Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with those obtained by ORC. PATIENTS AND METHODS: We retrospectively analyzed the data of 50 patients with MIBC treated by trimodal chemoradiotherapy with cisplatin (CDDP-radiation [CDDP-R])...
June 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28624175/prospective-study-comparing-laparoscopic-and-open-radical-cystectomy-surgical-and-oncological-results
#3
C Esquinas, J M Alonso, E Mateo, A Dotor, A M Martín, J F Dorado, I Arance, J C Angulo
INTRODUCTION: Laparoscopic radical cystectomy with lymphadenectomy and urinary diversion is an increasingly widespread operation. Studies are needed to support the oncological effectiveness and safety of this minimally invasive approach. PATIENTS AND METHODS: A nonrandomised, comparative prospective study between open radical cystectomy (ORC) and laparoscopic radical cystectomy (LRC) was conducted in a university hospital. The main objective was to compare cancer-specific survival...
June 14, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28624048/comparison-of-two-different-types-of-oxidized-regenerated-cellulose-for-partial-breast-defects
#4
Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Jung Dug Yang, Jeong Woo Lee, Junjie Li, Ho Yong Park
BACKGROUND: A defect after partial mastectomy, sometimes, is hard to be filled with patient's own breast tissue. Two different types of oxidized regenerated cellulose (ORC) for filling of partial defects in small-sized breasts were compared with respect to clinicopathologic factors and outcomes. METHODS: A total of 45 patients with breast cancer underwent conventional partial mastectomy with insertion of an ORC filling material. The two filling materials used were a hemostasis-purposed ORC and adhesion barrier-purposed ORC...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28606775/oxidized-regenerated-cellulose-fibrillar%C3%A2-reduces-risk-of-postoperative-corporal-bleeding-following-inflatable-penile-prosthesis-surgery
#5
Alexander T Rozanski, Boyd R Viers, Alexander G Liu, Nabeel A Shakir, Travis J Pagliara, Jeremy M Scott, Mary L West, Allen F Morey
OBJECTIVES: To report our initial experience with oxidized regenerated cellulose (ORC; Surgicel Fibrillar™) as a hemostatic adjunct during inflatable penile prosthesis (IPP) surgery. MATERIALS AND METHODS: Beginning in April 2016, ORC pledgets were placed within the corporotomy closures of all men undergoing IPP insertion. Perioperative characteristics and outcomes including cumulative postoperative drain output were evaluated among consecutive cases with (April 2016 to October 2016) and without ORC (December 2015 to March 2016) using an identical surgical technique by a single surgeon...
June 9, 2017: Urology
https://www.readbyqxmd.com/read/28599813/google-dengue-trends-an-indicator-of-epidemic-behavior-the-venezuelan-case
#6
Ricardo A Strauss, Julio S Castro, Ralf Reintjes, Jaime R Torres
INTRODUCTION: Dengue Fever is a neglected increasing public health thread. Developing countries are facing surveillance system problems like delay and data loss. Lately, the access and the availability of health-related information on the internet have changed what people seek on the web. In 2004 Google developed Google Dengue Trends (GDT) based on the number of search terms related with the disease in a determined time and place. The goal of this review is to evaluate the accuracy of GDT in comparison with traditional surveillance systems in Venezuela...
August 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28594939/ambiguity-in-the-processing-of-mandarin-chinese-relative-clauses-one-factor-cannot-explain-it-all
#7
Michael P Mansbridge, Katsuo Tamaoka, Kexin Xiong, Rinus G Verdonschot
This study addresses the question of whether native Mandarin Chinese speakers process and comprehend subject-extracted relative clauses (SRC) more readily than object-extracted relative clauses (ORC) in Mandarin Chinese. Presently, this has been a hotly debated issue, with various studies producing contrasting results. Using two eye-tracking experiments with ambiguous and unambiguous RCs, this study shows that both ORCs and SRCs have different processing requirements depending on the locus and time course during reading...
2017: PloS One
https://www.readbyqxmd.com/read/28591683/a-quantitative-risk-assessment-system-qr-as-evaluating-operation-safety-of-organic-rankine-cycle-using-flammable-mixture-working-fluid
#8
Hua Tian, Xueying Wang, Gequn Shu, Mingqiang Wu, Nanhua Yan, Xiaonan Ma
Mixture of hydrocarbon and carbon dioxide shows excellent cycle performance in Organic Rankine Cycle (ORC) used for engine waste heat recovery, but the unavoidable leakage in practical application is a threat for safety due to its flammability. In this work, a quantitative risk assessment system (QR-AS) is established aiming at providing a general method of risk assessment for flammable working fluid leakage. The QR-AS covers three main aspects: analysis of concentration distribution based on CFD simulations, explosive risk assessment based on the TNT equivalent method and risk mitigation based on evaluation results...
May 22, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28549758/prevalence-of-abdominal-obesity-and-its-association-with-cardio-metabolic-risk-factors-among-older-adults-in-ecuador
#9
Carlos H Orces, Martha Montalvan, Daniel Tettamanti
AIMS: To describe the prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador. MATERIALS AND METHODS: The present study used data from the National Survey of Health, Wellbeing, and Aging survey to examine the prevalence of abdominal obesity according to certain demographic, behavioral, and health characteristics of the participants. Logistic regression models adjusted for potential confounders were used to evaluate the association of abdominal obesity with cardio metabolic risk factors...
May 15, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28539704/comparison-of-antidiabetic-medications-during-the-treatment-of-atherosclerosis-in-t2dm-patients
#10
Xiaojie Liu, Tao Mei, Wei Chen, Shandong Ye
Type 2 diabetes is often associated with arterial atherosclerosis in large blood vessels. We set out to elucidate whether commonly used antidiabetic drugs metformin, sitagliptin, and pioglitazone will reduce atherosclerosis in T2DM patients. We enrolled 176 individuals with type 2 diabetes, which were divided into four treatment groups according to different oral drugs: metformin alone, sitagliptin alone, pioglitazone alone, or combination of metformin and sitagliptin. We assessed changes in glycometabolism, lipid metabolism, cytokine released, and carotid artery intima-media thickness as the readout for improvement in atherosclerosis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28506299/developmental-hip-dysplasia-treated-by-total-hip-arthroplasty-using-a-cementless-wagner-cone-stem-in-young-adult-patients-with-a-small-physique
#11
Ping Zhen, Jun Liu, Hao Lu, Hui Chen, Xusheng Li, Shenghu Zhou
BACKGROUND: Developmental hip dysplasia (DDH) may lead to severe acetabular and femoral abnormalities that can render total hip arthroplasty (THA) challenging, especially in DDH patients with a small physique. Most conventional cemented or cementless femoral components are often difficult to implant in the narrow femoral canal and require slight version correction during surgery. The aim of this study was to present the mid-term results of THA in the treatment of DDH patients with a small physique using a cementless Wagner cone prosthesis (Zimmer®, US)...
May 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28501329/eukaryotic-dna-replication-orchestrated-action-of-multi-subunit-protein-complexes
#12
REVIEW
Sukhyun Kang, Mi-Sun Kang, Eunjin Ryu, Kyungjae Myung
Genome duplication is an essential process to preserve genetic information between generations. The eukaryotic cell cycle is composed of functionally distinct phases: G1, S, G2, and M. One of the key replicative proteins that participate at every stage of DNA replication is the Mcm2-7 complex, a replicative helicase. In the G1 phase, inactive Mcm2-7 complexes are loaded on the replication origins by replication-initiator proteins, ORC and Cdc6. Two kinases, S-CDK and DDK, convert the inactive origin-loaded Mcm2-7 complex to an active helicase, the CMG complex in the S phase...
May 1, 2017: Mutation Research
https://www.readbyqxmd.com/read/28480342/a-preliminary-oncologic-outcome-and-postoperative-complications-in-patients-undergoing-robot-assisted-radical-cystectomy-initial-experience
#13
Satoru Muto, Kousuke Kitamura, Takeshi Ieda, Fumitaka Shimizu, Masayoshi Nagata, Shuji Isotani, Hisamitsu Ide, Raizo Yamaguchi, Shigeo Horie
PURPOSE: Robot-assisted radical cystectomy (RARC) was originally intended to replace open radical cystectomy (ORC) as a minimally invasive surgery for patients with invasive bladder cancer. The purpose of this study was to evaluate the advantages of robotic surgery, comparing perioperative and oncologic outcomes between RARC and ORC. MATERIALS AND METHODS: Between June 2012 and August 2016, 49 bladder cancer patients were given a radical cystectomy, 21 robotically and 28 by open procedure...
May 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28460449/laparoscopic-versus-open-radical-cystectomy-for-patients-with-bladder-cancer-over-75-year-old-a-prospective-randomized-controlled-trial
#14
Chen Yong, Chen Daihui, Zhou Bo
The aim of this study was to compare the morbidity, mortality, oncological results and quality of life between laparoscopic radical cystectomy (LRC) and open radical cystectomy (ORC) in the elderly patients over 75 years old. Between January 2012 and January 2015, 60 patients were recruited into this study, who were randomly assigned in a 1:1 ratio to either LRC or ORC group. Baseline patient characteristics, pathological factors, operative and postoperative characteristics, postoperative complications and survival data were retrospectively collected, analyzed and compared between the two groups...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427839/the-prevalence-of-metabolic-syndrome-among-older-adults-in-ecuador-results-of-the-sabe-survey
#15
Carlos H Orces, Enrique Lopez Gavilanez
AIMS: To describe the prevalence of metabolic syndrome among older adults in Ecuador. A secondary objective was to examine the relationship between metabolic syndrome and its components and insulin resistance among non-diabetic participants. MATERIALS AND METHODS: The National Survey of Health, Wellbeing, and Aging survey was used to examine the prevalence of metabolic syndrome according to demographic, behavioral, and health characteristics of the participants...
April 11, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28388886/allograft-tendon-reconstruction-of-the-anterior-talofibular-ligament-and-calcaneofibular-ligament-in-the-treatment-of-chronic-ankle-instability
#16
Weikai Wang, Guo Hong Xu
BACKGROUND: The purpose was retrospectively to investigate functional and clinical outcomes after anterior talofibular ligament (ATFL) and calcaneofibular ligament (CFL) reconstruction using a single allograft. METHODS: Patients with severe chronic lateral instability of the ankle underwent surgery after conservative treatment failed. Ultrasounds of the ankle were performed, and if the AFTL and CFL were completely torn without enough soft tissue for repair, the ligaments were reconstructed using allograft tendon...
April 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28365594/similar-dynamics-for-orc-and-y-rnas-in-replication
#17
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28353367/infant-behavior-questionnaire-revised-very-short-form-a-new-factor-structure-s-associations-with-parenting-perceptions-and-child-language-outcomes
#18
Elizabeth R Peterson, Karen E Waldie, Jatender Mohal, Elaine Reese, Polly E Atatoa Carr, Cameron C Grant, Susan M B Morton
The Infant Behavior Questionnaire Revised-Very Short Form (IBQ-R VSF; Putnam, Helbig, Gartstein, Rothbart, & Leerkes, 2014 ) is a new publicly available measure of infant temperament measuring positive affectivity/surgency (PAS), negative emotionality (NEG), and orienting and regulatory capacity (ORC). Although the initial psychometric properties of the 3-factor model appear promising, it has not been administered to a large and diverse sample and its predictive validity has not been established. This study administered the IBQ-R VSF to a diverse sample of 5,639 mothers of infants aged between 23 and 52 weeks...
March 29, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28350238/safety-and-effectiveness-of-robot-assisted-versus-open-radical-cystectomy-for-bladder-cancer-a-systematic-review-and-meta-analysis
#19
Soo Kyung Son, Na Rae Lee, Seok Ho Kang, Seon Heui Lee
OBJECTIVES: To evaluate the safety and effectiveness of robot-assisted radical cystectomy (RARC) compared with open radical cystectomy (ORC) in bladder cancer. METHODS: A literature search for the systematic review was conducted using international databases as well as domestic databases up to April 2015. Outcomes of interest included baseline characteristics, complication rates, perioperative, and oncologic outcomes. RESULTS: Twenty-four articles were finally selected for inclusion in the meta-analysis...
March 28, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28322723/nucleosomes-influence-multiple-steps-during-replication-initiation
#20
Ishara F Azmi, Shinya Watanabe, Michael F Maloney, Sukhyun Kang, Jason A Belsky, David M MacAlpine, Craig L Peterson, Stephen P Bell
Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct nucleosomal landscapes, different chromatin-remodeling enzymes (CREs) were used to remodel nucleosomes on origin-DNA templates. Nucleosomal organization influenced two steps of replication initiation: origin licensing and helicase activation...
March 21, 2017: ELife
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