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https://www.readbyqxmd.com/read/29124853/intracorporeal-robotic-assisted-radical-cystectomy-together-with-an-enhanced-recovery-programme-improves-postoperative-outcomes-by-aggregating-marginal-gains
#1
Wei Shen Tan, Mae-Yen Tan, Benjamin W Lamb, Ashwin Sridhar, Anna Mohammed, Hilary Baker, Senthil Nathan, Timothy Briggs, Melanie Tan, John D Kelly
OBJECTIVE: To assess the cumulative effect of an enhanced recovery after surgery (ERAS) pathway and a minimally invasive RARC with intracorporeal urinary diversion (iRARC) in comparison to open radical cystectomy (ORC) on hospital length of stay (LOS) and perioperative outcomes. MATERIALS & METHODS: Between Feb 2009 and Oct 2017, 304 radical cystectomy cases were performed at a single institution (54 ORC, 250 RARC). Data were prospectively collected. We identified 45 consecutive ORC cases performed without ERAS before the commencement of the RARC programme (Cohort A), 50 consecutive iRARC cases performed without ERAS (Cohort B) and 40 iRARC cases with ERAS (Cohort C)...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29123507/utilizing-biotinylated-proteins-expressed-in-yeast-to-visualize-dna-protein-interactions-at-the-single-molecule-level
#2
Huijun Xue, Yuanyuan Bei, Zhengyan Zhan, Xiuqiang Chen, Xin Xu, Yu V Fu
Much of our knowledge in conventional biochemistry has derived from bulk assays. However, many stochastic processes and transient intermediates are hidden when averaged over the ensemble. The powerful technique of single-molecule fluorescence microscopy has made great contributions to the understanding of life processes that are inaccessible when using traditional approaches. In single-molecule studies, quantum dots (Qdots) have several unique advantages over other fluorescent probes, such as high brightness, extremely high photostability, and large Stokes shift, thus allowing long-time observation and improved signal-to-noise ratios...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29107157/efficacy-reliability-and-safety-of-completely-autologous-fibrin-glue-in-neurosurgical-procedures-single-center-retrospective-large-number-case-study
#3
Noriyuki Nakayama, Hirohito Yano, Yusuke Egashira, Yukiko Enomoto, Naoyuki Ohe, Nobuhiro Kanemura, Junichi Kitagawa, Toru Iwama
OBJECTIVE: Commercially available fibrin glue (Com-FG) used commonly worldwide is produced with pooled human plasma from multiple donors and is added bovine aprotinin, however, which involves the risk of infection, allogenic immunity, and allergic reactions. We evaluate the efficacy, reliability, and safety of completely autologous fibrin glue (CAFG). METHODS: From August 2014 to February 2016, prospective data were collected and analyzed from 153 patients. CAFG was prepared with the CRYOSEAL(®) System using autologous blood and applied during neurosurgical procedures...
October 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29106817/application-of-the-aace-ace-advanced-framework-for-the-diagnosis-of-obesity-and-cardiometabolic-disease-staging-in-a-general-population-from-three-regions-of-venezuela-the-vemsols-study-results
#4
Ramfis Nieto-Martínez, Juan P González-Rivas, Eunice Ugel, Imperia Brajkovich, Alejandro Risquez, W Timothy Garvey, Jeffrey I Mechanick
OBJECTIVE: To determine the prevalence of obesity according to the AACE/ACE framework based on a complications-centric model with further application of the Cardiometabolic Disease Staging (CMDS) system in Venezuelan population. METHODS: 1,320 adults were randomly selected from 3 regions. AACE/ACE framework definitions: overweight: body mass index (BMI) 25 to 29.9 kg/m(2) and no obesity-related complications (ORC); obesity stage 0: BMI ≥ 30 and no ORC; stage 1: BMI ≥ 25 and one or more mild-to-moderate ORC; and stage 2: BMI ≥ 25 and one or more severe ORC...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29074622/replication-origin-flanking-roadblocks-reveal-origin-licensing-dynamics-and-altered-sequence-dependence
#5
Megan D Warner, Ishara F Azmi, Yanding Zhao, Sukhyun Kang, Stephen P Bell
In eukaryotes, DNA replication initiates from multiple origins of replication for timely genome duplication. These sites are selected by origin licensing, during which the core enzyme of the eukaryotic DNA replicative helicase, the Mcm2-7 (minichromosome maintenance) complex, is loaded at each origin. This origin licensing requires loading two Mcm2-7 helicases around origin DNA in a head-to-head orientation. Current models suggest that the origin recognition complex (ORC) and cell-division cycle 6 (Cdc6) proteins recognize and encircle origin DNA and assemble an Mcm2-7 double hexamer around adjacent double-stranded DNA...
October 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29049055/oxidized-regenerated-cellulose-collagen-dressings-review-of-evidence-and-recommendations
#6
Stephanie Wu, Andrew J Applewhite, Jeffrey Niezgoda, Robert Snyder, Jayesh Shah, Breda Cullen, Gregory Schultz, Janis Harrison, Rosemary Hill, Melania Howell, Marcus Speyrer, Howard Utra, Jean de Leon, Wayne Lee, Terry Treadwell
OBJECTIVE: Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose (ORC)/collagen dressing may offer healthcare providers a robust and cost-effective tool for use in a variety of wounds. DESIGN: A multidisciplinary panel meeting was convened to discuss the use of ORC/collagen dressings in wound care and provide practice recommendations...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29038254/characterization-of-copy-number-control-of-two-haloferax-volcanii-replication-origins-using-deletion-mutants-and-haloarchaeal-artificial-chromosomes-hacs
#7
Sandy Maurer, Katharina Ludt, Jörg Soppa
Haloferax volcanii is polyploid and contains about 20 genome copies under optimal conditions. However, the chromosome copy number is highly regulated and ranges from two during phosphate starvation to more than 40 under phosphate surplus. The aim of this study was the characterization of the influence of two replication origins on the genome copy number. The origin repeats and the genes encoding Origin Recognition Complex (ORC) proteins were deleted. The core origin oriC1-orc1 (ori1) deletion mutant had a lower genome copy number and a higher fitness than the wild-type, in stark contrast to the oriC2-orc5 (ori2) deletion mutant...
October 16, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/29035778/the-over-researched-community-an-ethics-analysis-of-stakeholder-views-at-two-south-african-hiv-prevention-research-sites
#8
Jennifer Koen, Douglas Wassenaar, Nicole Mamotte
Health research in resource-limited, multi-cultural contexts raises complex ethical concerns. The term 'over-researched community' (ORC) has been raised as an ethical concern and potential barrier to community participation in research. However, the term lacks conceptual clarity and is absent from established ethics guidelines and academic literature. In light of the concern being raised in relation to research in low- and middle-income countries (LMICs), a critical and empirical exploration of the meaning of ORC was undertaken...
October 7, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29027351/robotic-assisted-versus-open-radical-cystectomy-in-bladder-cancer-a-meta-analysis-of-four-randomized-controlled-trails
#9
Jin-Qiu Tang, Zhihong Zhao, Yiwen Liang, Guixiang Liao
BACKGROUND: Robot-assisted radical cystectomy (RARC) is increasing annually for treatment of bladder cancer. The objective of this meta-analysis was to compare the safety and efficacy of RARC and open radical cystectomy (ORC) for bladder cancer. METHODS: Our meta-analysis searches were conducted using PubMed, Web of Science, and Cochrane Library databases to identify randomized controlled trials (RCT) assessing the two techniques. RESULTS: Four RCT studies were identified, including 239 cases...
October 12, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29027010/oxidized-regenerated-cellulose-induces-pleural-thickening-in-patients-with-pneumothorax-possible-involvement-of-the-mesothelial-mesenchymal-transition
#10
Hiroki Ebana, Takuo Hayashi, Keiko Mitani, Etsuko Kobayashi, Toshio Kumasaka, Teruaki Mizobuchi, Masatoshi Kurihara, Fumiyuki Takahashi, Kazuhisa Takahashi, Kuniaki Seyama
PURPOSE: The pleural covering technique, i.e., wrapping a part of or the entire surface of the lung with oxidized regenerative cellulose (ORC), reinforces visceral pleura through pleural thickening for patients with pneumothorax and cystic lung diseases. However, it remains undetermined how ORC induces pleural thickening. METHODS: A histopathological examination was performed for lung specimens from patients who had recurrent pneumothoraces after pleural covering and re-operation (n = 5)...
October 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/28992413/phenotypic-optimization-of-urea-thiophene-carboxamides-to-yield-potent-well-tolerated-and-orally-active-protective-agents-against-aminoglycoside-induced-hearing-loss
#11
Sarwat Chowdhury, Kelly N Owens, R Jason Herr, Qin Jiang, Xinchao Chen, Graham Johnson, Vincent E Groppi, David W Raible, Edwin W Rubel, Julian A Simon
Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells, a robust model for mammalian auditory and vestibular hair cells, we identified a urea-thiophene carboxamide, 1 (ORC-001), as protective against aminoglycoside antibiotic (AGA)-induced hair cell death. The 50% protection (HC50) concentration conferred by 1 is 3.2 μM with protection against 200 μM neomycin approaching 100%. Compound 1 was sufficiently safe and drug-like to validate otoprotection in an in vivo rat hearing loss model...
October 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28984408/cost-analysis-of-open-radical-cystectomy-versus-robot-assisted-radical-cystectomy
#12
S S Bansal, T Dogra, P Weston Smith, S Amran, I Auluck, M S Bhambra, M S Sura, E Rowe, A Koupparis
OBJECTIVES: To perform a cost analysis comparing the cost of robot-assisted radical cystectomy (RARC) with open radical cystectomy (ORC) in a UK tertiary referral centre and to identify the key cost drivers. METHODS: Data on hospital stay, operative duration, transfusion rate and volume and complication rate were obtained from a prospectively updated institutional database for patients undergoing RARC or ORC. A cost decision tree model was created. Sensitivity analysis was performed to find key drivers of overall cost and to find breakeven points with ORC...
October 6, 2017: BJU International
https://www.readbyqxmd.com/read/28944964/wnt-%C3%AE-catenin-and-erk-pathway-activation-a-possible-mechanism-of-photobiomodulation-therapy-with-light-emitting-diodes-that-regulate-the-proliferation-of-human-outer-root-sheath-cells
#13
Jung E Kim, Young J Woo, Ki M Sohn, Kwan H Jeong, Hoon Kang
BACKGROUND: Outer root sheath cells (ORSCs) play important roles in maintaining hair follicle structure and provide support for the bulge area. The hair growth promoting effects of photobiomodulation therapy (PBMT) have been reported, but the mechanisms for this in human ORCs (hORSCs) have rarely been studied. OBJECTIVE: The aim of this study was to investigate the effect of various wavelengths of light-emitting diode (LED) irradiation on human ORSCs (hORSCs). METHODS: LED irradiation effects on hORSC proliferation and migration were examined with MTT assay, BrdU incorporation assay and migration assays...
September 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28934063/openness-to-adopting-evidence-based-practice-in-public-substance-use-treatment-in-south-africa-using-task-shifting-caseload-size-matters
#14
Jessica F Magidson, Jasper S Lee, Kim Johnson, Warren Burnhams, J Randy Koch, Ron Manderscheid, Bronwyn Myers
BACKGROUND: In response to the lack of coverage for substance use treatment in the Western Cape province of South Africa, the local government expanded funding for evidence-based practices (EBPs) for treating substance use. Yet, little is known about provider and staff attitudes towards adopting EBPs in this setting, which is particularly relevant in this context where task shifting clinical care increases demands on paraprofessional providers. This study aimed to (1) assess attitudes towards adopting EBPs among a range of staff working in substance use treatment in Cape Town using a task shifting model; and (2) evaluate factors associated with openness towards adopting EBPs in this setting...
September 21, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28931346/subhepatic-mass-occurrence-after-using-oxidized-and-regenerated-cellulose-polymer-in-laparoscopic-cholecystectomy-a-case-series
#15
Erasmo Spaziani, Annalisa Di Filippo, Piero Francioni, Martina Spaziani, Alessandro De Cesare, Marcello Picchio
BACKGROUND: Oxidized regenerated cellulose (ORC) is a bioabsorbable surgical hemostatic. We present the first prospective case series of circumscribed mass occurrence after using ORC in laparoscopic cholecystectomy. METHODS: Tabotamp (Ethicon, Inc., Somerville, NJ) in the form of tightly woven knitted patches was used to achieve hemostasis in 83 patients submitted to LC. RESULTS: A subhepatic mass was detected in five patients and radiologic characteristics were described...
September 20, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28891903/the-effectiveness-of-oxidized-regenerated-cellulose-as-a-graft-material-in-transalveolar-osteotome-sinus-lift-procedure
#16
Laith A Hussein, Thair A L Hassan
The posterior maxilla is challenged with postextraction alveolar bone resorption and pneumatization drive of the Schneiderian membrane that reduces the subantral distance. To overcome such anatomic obstacle a sinus augmentation procedure was introduced either via lateral or crestal approach depending on residual ridge height. The current study evaluated oxidized regenerated cellulose (ORC) as a grafting material versus osteon II by measuring bone gain and graft density, 24 weeks postoperatively. Twenty consecutive patients (24 cases) aged from 20 to 65 years were considered eligible after clinical and radiographic evaluation...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28867350/health-disparities-in-adolescent-bariatric-surgery-nationwide-outcomes-and-utilization
#17
Omar Nunez Lopez, Daniel C Jupiter, Fredrick J Bohanon, Ravi S Radhakrishnan, Kanika A Bowen-Jallow
PURPOSE: Bariatric surgery represents an appropriate treatment for adolescent severe obesity, but its utilization remains low in this patient population. We studied the impact of race and sex on preoperative characteristics, outcomes, and utilization of adolescent bariatric surgery. METHODS: Retrospective analysis (2007-2014) of adolescent bariatric surgery using the Bariatric Outcomes Longitudinal Database, a national database that collects bariatric surgical care data...
November 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28830467/biclamp%C3%A2-vessel-sealing-device-for-open-hepatic-resection-of-malignant-and-benign-liver-tumours-a-single-institution-experience
#18
Yi-Jun Zhao, Da-Chen Zhou, Fu-Bao Liu, Hong-Chuan Zhao, Guo-Bin Wang, Xiao-Ping Geng
BACKGROUND: Intraoperative blood loss during hepatectomy worsens prognosis, and various tools have been used to improve perioperative safety and feasibility. We aimed to retrospectively evaluate the feasibility and safety of the BiClamp® device for open liver resection. METHODS: We included 84 patients undergoing liver resection from a single centre, with all patients operated by the same surgical group. All hepatectomies were performed using BiClamp® (Erbe Elektromedizin GmbH, Tubingen, Germany), an electrosurgical device that simultaneously transects liver parenchyma and seals vessels <7 mm in diameter...
August 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28827288/the-yeast-heterochromatin-protein-sir3-experienced-functional-changes-in-the-aaa-domain-after-gene-duplication-and-subfunctionalization
#19
Ashleigh S Hanner, Laura N Rusche
A key unresolved issue in molecular evolution is how paralogs diverge after gene duplication. For multifunctional genes, duplication is often followed by subfunctionalization. Subsequently, new or optimized molecular properties may evolve once the protein is no longer constrained to achieve multiple functions. A potential example of this process is the evolution of the yeast heterochromatin protein Sir3, which arose by duplication from the conserved DNA replication protein Orc1 We previously found that Sir3 subfunctionalized after duplication...
October 2017: Genetics
https://www.readbyqxmd.com/read/28781123/the-high-affinity-interaction-between-orc-and-dna-that-is-required-for-replication-licensing-is-inhibited-by-2-arylquinolin-4-amines
#20
Nicola J Gardner, Peter J Gillespie, Jamie T Carrington, Emma J Shanks, Stuart P McElroy, Emma J Haagensen, Julie A Frearson, Andrew Woodland, J Julian Blow
In late mitosis and G1, origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2-7. A "licensing checkpoint" delays cells in G1 until sufficient origins have been licensed, but this checkpoint is lost in cancer cells. Inhibition of licensing can therefore kill cancer cells while only delaying normal cells in G1. In a high-throughput cell-based screen for licensing inhibitors we identified a family of 2-arylquinolin-4-amines, the most potent of which we call RL5a...
August 17, 2017: Cell Chemical Biology
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