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https://www.readbyqxmd.com/read/29346146/use-of-oxidized-regenerated-cellulose-collagen-matrix-in-chronic-diabetic-foot-ulcers-a-systematic-review
#1
Gisele Chicone, Viviane Fernandes de Carvalho, André Oliveira Paggiaro
OBJECTIVE: Diabetic wounds that do not heal completely usually exhibit inflammatory markers, increased protease activity, and reduced levels of growth factors and cell count. A systematic review was performed to determine whether there is enough evidence to support the use of an oxidized regenerated cellulose/collagen matrix (ORC+C) to treat diabetic foot ulcers (DFUs). METHODS: Study authors analyzed randomized controlled trials (RCTs) on ORC+C dressings for the treatment of DFUs...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29343302/does-previous-abdominal-surgery-adversely-affect-perioperative-and-oncologic-outcomes-of-laparoscopic-radical-cystectomy
#2
Xiaosong Wei, Jinjin Lu, Khurram Mutahir Siddiqui, Fan Li, Qianyuan Zhuang, Weimin Yang, Zhiquan Hu, Zhong Chen, Xiaodong Song, Shaogang Wang, Zhangqun Ye
BACKGROUND: Laparoscopic radical cystectomy (LRC) has been shown to have less estimated blood loss (EBL), transfusion rate, narcotic analgesic requirement, earlier return of bowel function, and shorter hospital stay. The aim of this study was to investigate the feasibility, peri-operative and oncologic outcomes of laparoscopic radical cystectomy (LRC) in patients with previous abdominal surgery (PAS). METHODS: We retrospectively reviewed 243 patients undergoing open radical cystectomy (ORC) or LRC with bilateral pelvic lymph node dissection and urinary diversion or cutaneous ureterostomy at a single center from January 2010 to December 2015...
January 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29317005/a-quantitative-systematic-review-and-meta-analysis-of-the-effectiveness-of-oral-cholera-vaccine-as-a-reactive-measure-in-cholera-outbreaks
#3
Patricia Schwerdtle, Coretta-Kings Onekon, Katrina Recoche
Introduction The efficacy of oral cholera vaccines (OCVs) in laboratory conditions has been established, and the World Health Organization (WHO; Geneva, Switzerland) has recommended their preventative use in high-risk settings. The WHO recommendation has not been fully operationalized, nor has it been extended to apply to the reactive use of OCVs in real field epidemic conditions due to concerns about potential resource diversion, feasibility, cost, and acceptability. The purpose of this study is to assess and synthesize existing evidence of OCV effectiveness when used reactively in real field conditions...
January 10, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29316106/robotic-assisted-radical-cystectomy-with-intracorporeal-urinary-diversion-versus-open-early-australian-experience
#4
Ken Chow, Homayoun Zargar, Niall M Corcoran, Anthony J Costello, Justin S Peters, Philip Dundee
BACKGROUND: The aim of this study was to describe our initial Australian single surgeon experience with robotic-assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) and to compare the outcomes with open radical cystectomy (ORC). METHODS: Between January 2014 and June 2016, consecutive patients diagnosed with muscle invasive and high-risk non-muscle invasive bladder cancer undergoing radical cystectomy were included. Treatment modalities included either RARC with ICUD or ORC...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29315997/systematic-review-and-meta-analysis-of-the-associations-between-maternal-methylenetetrahydrofolate-reductase-polymorphisms-and-preterm-delivery
#5
Qiwen Fang, Yixuan Jiang, Zhenqiu Liu, Zhijie Zhang, Tiejun Zhang
AIM: To date, reported associations between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and preterm delivery are conflicting. The present meta-analysis summarized the existing evidence and evaluated these associations. METHODS: Eligible studies were retrieved from Medline (PubMed), EMBASE, the Chinese Biomedical Literature Database and the Cochrane Library. We calculated pooled odds ratios (ORs) and 95% confidence interval (CIs) within five genetic models using either random-effects or fixed-effects models dependent on study heterogeneity...
January 5, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29311751/measurement-and-correlation-of-the-viscosity-of-1-1-1-2-2-4-5-5-5-nonafluoro-4-trifluoromethyl-3-pentanone
#6
Chenyang Wen, Xianyang Meng, Marcia L Huber, Jiangtao Wu
The Paris Agreement on climate change, in which many nations have agreed to limit greenhouse gas emissions, has spurred interest in developing working fluids with low global warming potential (GWP) that can satisfy environmental concerns and have thermophysical properties that can meet engineering performance requirements. One such fluid is 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-pentanone (also known as Novec-649 and Novec-1230), which has potential applications in organic Rankine cycles (ORC), electronics cooling, computer/data center cooling and fire extinguishing...
October 12, 2017: Journal of Chemical and Engineering Data
https://www.readbyqxmd.com/read/29301543/towards-evidence-based-palliative-care-in-nursing-homes-in-sweden-a-qualitative-study-informed-by-the-organizational-readiness-to-change-theory
#7
Per Nilsen, Birgitta Wallerstedt, Lina Behm, Gerd Ahlström
BACKGROUND: Sweden has a policy of supporting older people to live a normal life at home for as long as possible. Therefore, it is often the oldest, most frail people who move into nursing homes. Nursing home staff are expected to meet the existential needs of the residents, yet conversations about death and dying tend to cause emotional strain. This study explores organizational readiness to implement palliative care based on evidence-based guidelines in nursing homes in Sweden. The aim was to identify barriers and facilitators to implementing evidence-based palliative care in nursing homes...
January 4, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29281852/evolution-of-cystectomy-care-over-a-11-years-period-in-a-high-volume-tertiary-referral-center
#8
Aldo Brassetti, Axel Möller, Oscar Laurin, Jonas Höijer, Christofer Adding, Ayako Miyakawa, Abolfazl Hosseini, Peter Wiklund
OBJECTIVES: To describe the evolution RC care over 11 years in a referral center. MATERIALS AND METHODS: Clinical data of patients undergoing either open RC (ORC) or robot-assisted RC (RARC) for cT1-4aN0M0 bladder cancer (BCa) at our center between 01/2006 and 12/2016 were retrospectively evaluated. Crude and propensity score weighted log-binomial regression analyses assessed the association between pre-/perioperative variables and the risk of reoperation, intensive care unit (ICU) admission and death within 90 days after RC...
December 27, 2017: BJU International
https://www.readbyqxmd.com/read/29277584/comparative-effectiveness-of-robot-assisted-vs-open-radical-cystectomy
#9
Nawar Hanna, Jeffrey J Leow, Maxine Sun, David F Friedlander, Thomas Seisen, Firas Abdollah, Stuart R Lipsitz, Mani Menon, Adam S Kibel, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
OBJECTIVES: Over the past decade, robot-assisted radical cystectomy (RARC) has gained traction as an alternative to the conventional open approach open radical cystectomy (ORC). However, the benefits of RARC over ORC remain unclear. Our objective was to conduct a comparative effectiveness analysis between RARC and ORC using data from the National Cancer Data Base. MATERIALS AND METHODS: Within the National Cancer Data Base, we identified patients with localized muscle-invasive bladder cancer who underwent RC between 2010 and 2013...
December 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29276424/are-they-ready-organizational-readiness-for-change-among-clinical-teaching-teams
#10
Lindsay Bank, Mariëlle Jippes, Jimmie Leppink, Albert Jja Scherpbier, Corry den Rooyen, Scheltus J van Luijk, Fedde Scheele
Introduction: Curriculum change and innovation are inevitable parts of progress in postgraduate medical education (PGME). Although implementing change is known to be challenging, change management principles are rarely looked at for support. Change experts contend that organizational readiness for change (ORC) is a critical precursor for the successful implementation of change initiatives. Therefore, this study explores whether assessing ORC in clinical teaching teams could help to understand how curriculum change takes place in PGME...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29273826/frax-based-intervention-and-assessment-thresholds-in-seven-latin-american-countries
#11
P Clark, E Denova-Gutiérrez, C Zerbini, A Sanchez, O Messina, J J Jaller, C Campusano, C H Orces, G Riera, H Johansson, J A Kanis
Age-specific intervention and assessment thresholds were developed for seven Latin American countries. The intervention threshold ranged from 1.2% (Ecuador) to 27.5% (Argentina) at the age of 50 and 90 years, respectively. In the Latin American countries, FRAX offers a substantial advance for the detection of subjects at high fracture risk. INTRODUCTION: Intervention thresholds are proposed using the Fracture Risk Assessment (FRAX) tool. We recommended their use to calculate the ten-year probability of fragility fracture (FF) in both, men and women with or without the inclusion of bone mineral density (BMD)...
December 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29273428/prevalence-of-prediabetes-and-diabetes-among-older-adults-in-ecuador-analysis-of-the-sabe-survey
#12
Carlos H Orces, Carlos Lorenzo
AIMS: To examine the prevalence of prediabetes and diabetes among subjects aged 60 years and older in Ecuador. MATERIALS AND METHODS: The present study used data from the National Survey of Health, Wellbeing, and Aging to describe the prevalence of prediabetes and diabetes among older adults. Logistic regression models were assembled to examine the association between certain demographic and health characteristics of participants and prediabetes and diabetes prevalence rates...
December 16, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29261034/mcm-interference-during-licensing-of-dna-replication-in-xenopus-egg-extracts-possible-role-of-a-c-terminal-region-of-mcm3
#13
Satoru Mimura, Yumiko Kubota, Haruhiko Takisawa
The minichromosome maintenance (MCM) complex, consisting of six subunits, Mcm2-7, is loaded onto replication origins through loading factors (origin recognition complex [ORC], Cdc6, and Cdt1) and forms an MCM double hexamer that licenses the initiation of DNA replication. Previous studies with Xenopus egg extracts showed that loading factors, especially Cdc6, dissociate from chromatin on MCM loading, but the molecular mechanism and physiological significance remain largely unknown. Using a cell-free system for MCM loading onto plasmid DNA in Xenopus egg extracts, we found that MCM loaded onto DNA prevents DNA binding of the loading factors ORC, Cdc6, and Cdt1...
December 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29238233/an-in-vivo-comparison-of-the-efficacy-of-hemostatic-powders-using-two-porcine-bleeding-models
#14
Melinda H MacDonald, Allen Y Wang, Jeffrey W Clymer, Richard W Hutchinson, Richard Kocharian
Background: Usage of topical hemostatic agents in surgery is increasing, including use during minimally invasive procedures, and even for surgeries that have a low risk of bleeding complications. A novel product, Surgicel® Powder - Absorbable Hemostatic Powder (SP), made from oxidized regenerated cellulose (ORC) fabric, has been developed for adjunctive use in surgical procedures to assist in control of oozing bleeding over broad areas and where access could be difficult with a fabric ORC product...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29225619/clinical-application-of-ct-guided-percutaneous-microwave-ablation-for-the-treatment-of-lung-metastasis-from-colorectal-cancer
#15
Lin Li, Ketong Wu, Haiyang Lai, Bo Zhang
Objective: The aim of our research is to explore the clinical efficacy and safety of CT-guided percutaneous microwave ablation (MWA) for the treatment of lung metastasis from colorectal cancer. Materials and Methods: CT-guided percutaneous MWA was performed in 22 patients (male 14, female 8, mean age: 56.05 ± 12.32 years) with a total of 36 lung metastatic lesions from colorectal cancer between February 2014 and May 2017. Clinical data were retrospectively analyzed with respect to the efficacy, safety, and outcome...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29218651/increasing-hip-fracture-rates-among-older-adults-in-ecuador-analysis-of-the-national-hospital-discharge-system-1999-2016
#16
Carlos H Orces, Enrique Lopez Gavilanez
The Ecuadorian hospital discharge system examined trends in hip fracture hospitalization rates among older adults. A significant upward trend in hip fracture rates occurred in both genders over the study period. INTRODUCTION: Previous research has reported increasing hip fracture rates in Ecuador. Thus, this study aimed to extend previous findings by examining the nationwide incidence of hip fractures among adults aged 65 years and older between 1999 and 2016. A secondary objective was to compare hip fracture trends among older Ecuadorians with their counterparts in the United States (U...
December 7, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29195597/organizational-readiness-for-change-orc-test-used-in-the-implementation-of-assessment-instruments-and-treatment-methods-in-a-swedish-national-study
#17
Johan Billsten, Mats Fridell, Robert Holmberg, Andréas Ivarsson
Organizational climate and related factors are associated with outcome and are as such of vital interest for healthcare organizations. Organizational Readiness for Change (ORC) is the questionnaire used in the present study to assess the influence of organizational factors on implementation success. The respondents were employed in one of 203 Swedish municipalities within social work and psychiatric substance/abuse treatment services. They took part in a nationwide implementation project organized by the Swedish Association of Local Authorities and Regions (SALAR), commissioned by the Swedish National Board of Health and Welfare...
January 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29193757/effects-of-the-consumption-of-milk-biofortified-with-selenium-vitamin-e-and-different-fatty-acid-profile-on-immune-response-in-the-elderly
#18
Karina Pfrimer, Eduardo Ferriolli, Paula Lumy Takeuchi, Márcia Msv Salles, Arlindo Saran-Netto, Marcus A Zanetti, Luiz C Roma-Junior, Camila Bitu Moreno Braga, Fernanda A Domenici, Yara Ml Valim, Adriana Bp Paschoalato, Larissa F Marchi, Ana Ecs Azzolini, Eduardo A Donadi, Edson Martinez, Helio Vannucchi
SCOPE: Nutrition is a major contributing factor for immunocompetence. The aim was to assess the immune status of older after consuming a milk produced by lactating cows fed with one of the following diets: control diet(C), C+vitaminE+selenium(C+A), C+sunfloweroil(C+O), orC+sunflower oil+vitaminE+selenium(A+O). METHODS AND RESULTS: 60elderly received one of these biofortified milks during 12weeks. Immune response was assessed by measurement of the expression of COX-1,2, MCP-1, PPAR(δ,α and β/δ)genes, neutrophil production of oxygen reactive species induced by immune complexes, neutrophil phagocytosis and lytic activity of the alternative pathway of the complement system and cytokine levels...
November 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29187216/use-of-a-flowable-haemostat-versus-an-oxidised-regenerated-cellulose-agent-in-primary-elective-cardiac-surgery-economic-impact-from-a-uk-healthcare-perspective
#19
Mayur R Joshi, Jacqueline Latham, Gabriel Okorogheye
BACKGROUND: Flowable haemostatic agents have been shown to be superior to non-flowable agents in terms of haemostatic control and need for transfusion products in patients undergoing cardiac surgery. We investigated the economic impact of the use of a flowable haemostatic agent (Floseal) compared with non-flowable oxidised regenerated cellulose (ORC) agent in primary elective cardiac surgery from the perspective of the UK National Health Service (NHS). METHODS: A cost-consequence framework based upon clinical data from a prospective trial and an observational trial and NHS-specific actual reference costs (2016) was developed to compare the economic impact of Floseal with that of ORC...
November 29, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29159177/effectiveness-of-chinese-herbal-medicine-combined-with-antibiotics-for-extensively-drug-resistant-enterobacteria-and-nonfermentative-bacteria-infection-real-life-experience-in-a-retrospective-cohort
#20
Yangping Cai, Qing Zhang, Yuefeng Fu, Li Li, Ning Zhao, Aiping Lu, Qingquan Liu, Miao Jiang
Chinese herbal medicines (CHMs) have been successfully used in the treatment of infectious diseases, yet the effectiveness of CHMs for extensively drug-resistant enterobacteria (XDRE) infection remains unclear. Herein we developed a retrospective multicenter study including 766 patients with XDRE and nonfermentative bacteria (NFB) infection to investigate the effectiveness of CHMs combined with antibiotics in the treatment of XDRE infections in clinical daily practice in a cohort of patients and compared the regular antibiotics monotherapy...
2017: BioMed Research International
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