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https://www.readbyqxmd.com/read/27913205/trp-channels-in-calcium-homeostasis-from-hormonal-control-to-structure-function-relationship-of-trpv5-and-trpv6
#1
REVIEW
Mark K C van Goor, Joost G J Hoenderop, Jenny van der Wijst
Maintaining plasma calcium levels within a narrow range is of vital importance for many physiological functions. Therefore, calcium transport processes in the intestine, bone and kidney are tightly regulated to respectively fine-tune the rate of absorption, storage and excretion. The TRPV5 and TRPV6 calcium channels are viewed as the gatekeepers of epithelial calcium transport. Several calciotropic hormones control the channels at the level of transcription, membrane expression, and function. Recent technological advances have provided the first near-atomic resolution structural models of several TRPV channels, allowing insight into their architecture...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27891582/versatile-roles-of-intracellularly-located-trpv1-channel
#2
REVIEW
Rui Zhao, Suk Ying Tsang
The ubiquitous expression in many organs throughout the body and the ability to respond to a wide variety of physical and chemical stimuli have brought transient receptor potential (TRP) channels to the vanguards of our sensory systems. TRP vanilloid-1 (TRPV1) is the founding member of the TRPV subfamily. TRPV1 can be activated by noxious heat, protons and vanilloids. Previous studies have shown that TRPV1 is located on the plasma membrane, serving to non-selectively permeate calcium ion from the extracellular region to the cytoplasm...
November 27, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27875791/localization-and-expression-patterns-of-trp-channels-in-submandibular-gland-development
#3
Motoya Fujiseki, Masahito Yamamoto, Sobhan Ubaidus, Takashi Shinomiya, Shinichi Abe, Masakazu Tazaki, Hitoshi Yamamoto
OBJECTIVE: Expression of Transient receptor potential (TRP) channels: TRP canonical (TRPC)1, TRP vanilloid (TRPV)3, TRPV4 and TRP melastatin (TRPM)8 in adult rat salivary gland has recently been reported. The authors investigated expression of these TRP channels in the submandibular gland during early developmental stage in which the cell constitution is different, and discussed the function of TRP in the submandibular gland in early development. DESIGN: Using rat submandibular gland at embryonic days (E)18 and E20 and postnatal days (PN)0 and PN5 and PN28, expression of TRPV3, TRPV4, TRPC1 and TRPM8 was investigated using real-time polymerase chain reaction (RT-PCR) and immunohistochemistry...
November 11, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27871896/gastroprotective-and-ulcer-healing-effects-of-hydroethanolic-extract-of-leaves-of-caryocar-coriaceum-mechanisms-involved-in-the-gastroprotective-activity
#4
Luis Jardelino de Lacerda Neto, Andreza Guedes Barbosa Ramos, Valterlucio Santos Sales, Severino Denicio Gonçalves de Souza, Antonia Thassya Lucas Dos Santos, Larissa Rolim de Oliveira, Marta Regina Kerntopf, Thais Rodrigues de Albuquerque, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans-Júnior, Almir Gonçalves Wanderley, Irwin Rose Alencar de Menezes
This work aimed to determine the chemical fingerprint of hydroethanolic extract of leaves of Caryocar coriaceum (HELCC) and the gastroprotective activity. The chemical fingerprint of HELCC was analyzed by HPLC-DAD, to quantify total phenols and flavonoids were carried out by Folin-Ciocalteu reagent and aluminum chloride assay, while in vitro antioxidant activity was evaluated by the DPPH method. The methods used to determine pharmacological activity were: gastroprotective screening test in classical models of induced acute and chronic gastric lesions and physical barrier test...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27829230/post-transcriptional-regulation-of-5-untranslated-regions-of-human-transient-receptor-potential-vanilloid-type-1-trpv-1-channels-role-in-the-survival-of-glioma-patients
#5
Massimo Nabissi, Maria Beatrice Morelli, Antonietta Arcella, Claudio Cardinali, Matteo Santoni, Giovanni Bernardini, Angela Santoni, Giorgio Santoni, Consuelo Amantini
The Transient Receptor Potential Vanilloid type-1 (TRPV1) channel is a non-selective cation channel belonging to the Transient Receptor Potential family; variation of its expression has been correlated to glioma progression. In human, TRPV1 transcripts display a remarkable homogeneity differing only for the 5'-untranslated region (5'UTR) sequence that generates four variants encoding the same protein. Herein, we investigated the role of the 5'UTR sequences in TRPV1 transcripts stability, regulation of translation, expression in glioma cells and tissues...
November 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27824033/promotion-of-behavior-and-neuronal-function-by-reactive-oxygen-species-in-c-elegans
#6
Guang Li, Jianke Gong, Haoyun Lei, Jianfeng Liu, X Z Shawn Xu
Reactive oxygen species (ROS) are well known to elicit a plethora of detrimental effects on cellular functions by causing damages to proteins, lipids and nucleic acids. Neurons are particularly vulnerable to ROS, and nearly all forms of neurodegenerative diseases are associated with oxidative stress. Here, we report the surprising finding that exposing C. elegans to low doses of H2O2 promotes, rather than compromises, sensory behavior and the function of sensory neurons such as ASH. This beneficial effect of H2O2 is mediated by an evolutionarily conserved peroxiredoxin-p38/MAPK signaling cascade...
November 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27807168/a-defensive-kicking-behavior-in-response-to-mechanical-stimuli-mediated-by-drosophila-wing-margin-bristles
#7
Jiefu Li, Wei Zhang, Zhenhao Guo, Sophia Wu, Lily Yeh Jan, Yuh-Nung Jan
: Mechanosensation, one of the fastest sensory modalities, mediates diverse behaviors including those pertinent for survival. It is important to understand how mechanical stimuli trigger defensive behaviors. Here, we report that Drosophila melanogaster adult flies exhibit a kicking response against invading parasitic mites over their wing margin with ultrafast speed and high spatial precision. Mechanical stimuli that mimic the mites' movement evoke a similar kicking behavior. Further, we identified a TRPV channel, Nanchung, and a specific Nanchung-expressing neuron under each recurved bristle that forms an array along the wing margin as being essential sensory components for this behavior...
November 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27731314/nicotinamide-is-an-endogenous-agonist-for-a-c-elegans-trpv-osm-9-and-ocr-4-channel
#8
Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J Mickolajczyk, Matthew Shorey, Laura E Rohan, Katherine A Billings, Melissa M Rolls, William O Hancock, Wendy Hanna-Rose
TRPV ion channels are directly activated by sensory stimuli and participate in thermo-, mechano- and chemo-sensation. They are also hypothesized to respond to endogenous agonists that would modulate sensory responses. Here, we show that the nicotinamide (NAM) form of vitamin B3 is an agonist of a Caenorhabditis elegans TRPV channel. Using heterologous expression in Xenopus oocytes, we demonstrate that NAM is a soluble agonist for a channel consisting of the well-studied OSM-9 TRPV subunit and relatively uncharacterized OCR-4 TRPV subunit as well as the orthologous Drosophila Nan-Iav TRPV channel, and we examine stoichiometry of subunit assembly...
October 12, 2016: Nature Communications
https://www.readbyqxmd.com/read/27705979/functional-expression-of-an-osmosensitive-cation-channel-transient-receptor-potential-vanilloid-4-in-rat-vestibular-ganglia
#9
Takefumi Kamakura, Makoto Kondo, Yoshihisa Koyama, Yukiko Hanada, Yusuke Ishida, Yukiko Nakamura, Takahiro Yamada, Yasumitsu Takimoto, Tadashi Kitahara, Yoshiyuki Ozono, Arata Horii, Takao Imai, Hidenori Inohara, Shoichi Shimada
Transient receptor potential vanilloid (TRPV) 4 is a nonselective cation channel expressed in sensory neurons such as those in the dorsal root and trigeminal ganglia, kidney, and inner ear. TRPV4 is activated by mechanical stress, heat, low osmotic pressure, low pH, and phorbol derivatives such as 4α-phorbol 12,13-didecanoate (4α-PDD). We investigated the expression of TRPV4 in rat vestibular ganglion (VG) neurons. The TRPV4 gene was successfully amplified from VG neuron mRNA using reverse-transcription polymerase chain reaction...
October 6, 2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27623929/oleoylethanolamine-and-palmitoylethanolamine-modulate-intestinal-permeability-in-vitro-via-trpv1-and-ppar%C3%AE
#10
Mustafa A Karwad, Tara Macpherson, Bo Wang, Elena Theophilidou, Sarir Sarmad, David A Barrett, Michael Larvin, Karen L Wright, Jonathan N Lund, Saoirse E O'Sullivan
Cannabinoids modulate intestinal permeability through CB1 The endocannabinoid-like compounds oleoylethanolamine (OEA) and palmitoylethanolamine (PEA) play an important role in digestive regulation, and we hypothesized they would also modulate intestinal permeability. Transepithelial electrical resistance (TEER) was measured in human Caco-2 cells to assess permeability after application of OEA and PEA and relevant antagonists. Cells treated with OEA and PEA were stained for cytoskeletal F-actin changes and lysed for immunoassay...
September 13, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27614169/endoglin-selectively-modulates-transient-receptor-potential-channel-expression-in-left-and-right-heart-failure
#11
Kevin J Morine, Vikram Paruchuri, Xiaoying Qiao, Mark Aronovitz, Gordon S Huggins, David DeNofrio, Michael S Kiernan, Richard H Karas, Navin K Kapur
INTRODUCTION: Transient receptor potential (TRP) channels are broadly expressed cation channels that mediate diverse physiological stimuli and include canonical (TRPC), melastatin (TRPM), and vanilloid (TRPV) subtypes. Recent studies have implicated a role for TRPC6 channels as an important component of signaling via the cytokine, transforming growth factor beta 1 (TGFβ1) in right (RV) or left ventricular (LV) failure. Endoglin (Eng) is a transmembrane glycoprotein that promotes TRPC6 expression and TGFβ1 activity...
August 21, 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27605519/egfr-cell-survival-signaling-requires-phosphatidylcholine-biosynthesis
#12
Matt Crook, Awani Upadhyay, Liyana J Ido, Wendy Hanna-Rose
Identification of pro-cell-survival signaling pathways has implications for cancer, cardiovascular and neurodegenerative disease. We show that the Caenorhaditis elegans epidermal growth factor receptor LET-23 has a pro-survival function in counteracting excitotoxicity, and we identify novel molecular players required for this pro-survival signaling. uv1 sensory cells in the C. elegans uterus undergo excitotoxic death in response to activation of the OSM-9/OCR-4 TRPV channel by the endogenous agonist nicotinamide...
September 7, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27496302/trp-channels-in-schistosomes
#13
Swarna Bais, Robert M Greenberg
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helminth ion channels have been assessed for their pharmacological properties or for their roles in parasite physiology...
July 27, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27436489/suppression-of-trpv4-channels-ameliorates-anti-dipsogenic-effects-under-hypoxia-in-the-subfornical-organ-of-rats
#14
Fan Yang, Li Zhou, Dong Wang, Li-Li Yang, Guo-Rong Yuan, Qing-Yuan Huang
The phenomenon of water intake reduction during the 1(st) day of hypobaric hypoxia has been known for a long time. However, the reason for the same is yet unknown. The transient receptor potential vanilloid (TRPV) channels, including TRPV1 and TRPV4, are located in the subfornical organ (SFO). These are calcium permeable cationic channels gated by various stimuli such as cell swelling, low pH, and high temperature, and participate in anti-dipsogenic effects when activated. We aimed to explore the drinking behavior of rats and the mechanism of TRPVs under hypoxia...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27409607/regulation-of-intestinal-epithelial-calcium-transport-proteins-by-stanniocalcin-1-in-caco2-cells
#15
Jinmei Xiang, Rui Guo, Chunyun Wan, Liming Wu, Shijin Yang, Dingzong Guo
Stanniocalcin-1 (STC1) is a calcium and phosphate regulatory hormone. However, the exact molecular mechanisms underlying how STC1 affects Ca(2+) uptake remain unclear. Here, the expression levels of the calcium transport proteins involved in transcellular transport in Caco2 cells were examined following over-expression or inhibition of STC1. These proteins include the transient receptor potential vanilloid members (TRPV) 5 and 6, the plasma membrane calcium ATPase 1b (PMCA1b), the sodium/calcium exchanger (NCX1), and the vitamin D receptor (VDR)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27400483/analysis-of-factors-influencing-moxibustion-efficacy-by-affecting-heat-activated-transient-receptor-potential-vanilloid-channels
#16
REVIEW
Jinfeng Jiang, Xinjun Wang, Xiaojing Wu, Zhi Yu
Moxibustion is an important component part of Traditional Chinese Medicine (TCM). Among differ- ent kinds of moxibustion methods, thermal stimulation seems to be a pivotal impact factor to the theraputic efficacy. Based on its thermal characteristic and treated area-skin, we hypothesize that the thermosensitive TRPV channels may involve in the mechanism of moxibustion. This study, by referring to various experimental and clinical data, analyzes the properties and features of transient receptor potential vanilloid (TRPV) subfamily 1-4 and the impact of moxibustion on these channels...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/27351255/developmental-programming-modulates-olfactory-behavior-in-c-elegans-via-endogenous-rnai-pathways
#17
Jennie R Sims, Maria C Ow, Mailyn A Nishiguchi, Kyuhyung Kim, Piali Sengupta, Sarah E Hall
Environmental stress during early development can impact adult phenotypes via programmed changes in gene expression. C. elegans larvae respond to environmental stress by entering the stress-resistant dauer diapause pathway and resume development once conditions improve (postdauers). Here we show that the osm-9 TRPV channel gene is a target of developmental programming and is down-regulated specifically in the ADL chemosensory neurons of postdauer adults, resulting in a corresponding altered olfactory behavior that is mediated by ADL in an OSM-9-dependent manner...
2016: ELife
https://www.readbyqxmd.com/read/27329106/the-preventive-effect-of-resiniferatoxin-on-the-development-of-cold-hypersensitivity-induced-by-spinal-nerve-ligation-involvement-of-trpm8
#18
Won Uk Koh, Seong-Soo Choi, Ji Hyun Kim, Hye Joo Yoon, Ho-Soo Ahn, Sun Kyung Lee, Jeong Gil Leem, Jun Gol Song, Jin Woo Shin
BACKGROUND: Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated the preventive effect of perineural RTX on the development of cold hypersensitivity induced by spinal nerve ligation (SNL) in rats. Furthermore, we examined the association between the expression level of TRPV1, TRP ankyrin type (TRPA) 1 and TRP melastatin type (TRPM) 8 in the dorsal root ganglion (DRG) and cold hypersensitivity after SNL...
2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27291418/a-molecular-determinant-of-phosphoinositide-affinity-in-mammalian-trpv-channels
#19
Phanindra Velisetty, Istvan Borbiro, Marina A Kasimova, Luyu Liu, Doreen Badheka, Vincenzo Carnevale, Tibor Rohacs
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P2 affinity in mammalian ion channels. Here we report that two members of the Transient Receptor Potential Vanilloid (TRPV) ion channel family, TRPV5 and TRPV6 lack a positively charged residue in the TM4-TM5 loop that was shown to interact with PI(4,5)P2 in TRPV1, which shows high affinity for this lipid...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27278225/aqueous-extract-of-pomegranate-seed-attenuates-glucocorticoid-induced-bone-loss-and-hypercalciuria-in-mice-a-comparative-study-with-alendronate
#20
Yan Zhang, Jin Shao, Zhi Wang, Tieyi Yang, Shuyi Liu, Yue Liu, Xinbing Fan, Weiguang Ye
The present study was performed in order to examine bone loss and calcium homeostasis in mice with glucocorticoid (GC)-induced osteoporosis (GIOP) following treatment with the aqueous extract of pomegranate seed (AE-PS). In addition, a comparative study with alendronate was performed. Biomarkers in the serum and the urine were measured. The tibias, kidney and duodenum were removed in order to measure the levels of bone calcium, protein expression as well as to perform histomorphological analysis of the bone...
August 2016: International Journal of Molecular Medicine
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