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https://www.readbyqxmd.com/read/28088244/study-of-the-variability-of-scapular-inclination-and-the-glenoid-version-considerations-for-preoperative-planning-clinical-radiological-study
#1
Petr Fulin, Martin Kysilko, David Pokorny, Radek Padr, Nikola Kasprikova, Ivan Landor, Antonin Sosna
BACKGROUND: Preoperative planning with the aid of imaging methods is a principal factor in successful surgery on the shoulder. This work aims to evaluate the variability of glenoid version, spiralling twist and scapular inclination in relation to the frontal axis. Studies focusing on measuring the variability of scapular inclination in the standardised rest position are lacking in the literature. METHODS: We evaluated 104 CT scans of the shoulder. We measured the glenoid version with respect to the scapular axis at three levels...
January 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28079125/establishment-of-a-integrative-multi-omics-expression-database-ckddb-in-the-context-of-chronic-kidney-disease-ckd
#2
Marco Fernandes, Holger Husi
Complex human traits such as chronic kidney disease (CKD) are a major health and financial burden in modern societies. Currently, the description of the CKD onset and progression at the molecular level is still not fully understood. Meanwhile, the prolific use of high-throughput omic technologies in disease biomarker discovery studies yielded a vast amount of disjointed data that cannot be easily collated. Therefore, we aimed to develop a molecule-centric database featuring CKD-related experiments from available literature publications...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28059167/splicing-imbalances-in-basal-like-breast-cancer-underpin-perturbation-of-cell-surface-and-oncogenic-pathways-and-are-associated-with-patients-survival
#3
Filipe Gracio, Brian Burford, Patrycja Gazinska, Anca Mera, Aisyah Mohd Noor, Pierfrancesco Marra, Cheryl Gillett, Anita Grigoriadis, Sarah Pinder, Andrew Tutt, Emanuele de Rinaldis
Despite advancements in the use of transcriptional information to understand and classify breast cancers, the contribution of splicing to the establishment and progression of these tumours has only recently starting to emerge. Our work explores this lesser known landscape, with special focus on the basal-like breast cancer subtype where limited therapeutic opportunities and no prognostic biomarkers are currently available. Using ExonArray analysis of 176 breast cancers and 9 normal breast tissues we demonstrate that splicing levels significantly contribute to the diversity of breast cancer molecular subtypes and explain much of the differences compared with normal tissues...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057950/reduction-of-30-day-hospital-readmissions-after-patient-centric-telephonic-medication-therapy-management-services
#4
Daryl E Miller, Teresa E Roane, Karen D McLin
Background: Transitional care programs are a growing topic in health care systems across the country, with a focus on achieving a reduction in hospital readmissions and improving patient and medication safety. Numerous strategies have been employed and studied to determine successful approaches to patient transition from the hospital setting to the home setting. Pharmacist-mediated postdischarge telephonic outreach has demonstrated decreased hospital readmission rates in multiple hospital systems. Objective: To evaluate the effectiveness of pharmacist-facilitated telephonic medication therapy management (MTM) services on reducing hospital readmissions...
December 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/28050989/nonsurgical-management-of-adult-skeletal-class-3-with-deep-bite-utilizing-mini-implants
#5
Ali G Alhalabi, Salah Mahaini, Ghalia Shebib, Khaldoun Darwich, Luai Mahaini
Malocclusions with anterior crossbite are a major esthetic and functional concern for patients. This case report presents a 27-year-old Syrian female who was diagnosed with a class 3 malocclusion, combined with anterior crossbite, deep bite, concave profile, and inadequate maxillary incisor exposure. There was a centric occlusion (CO)/centric relation (CR) discrepancy and the mandible could be manipulated to near edge-to-edge incisal relation. Correction was done by class 3 intermaxillary elastics on upper and lower mini-implants for the first 6 months, followed by preadjusted edgewise appliance...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28039566/the-structure-of-fcpb-a-light-harvesting-complex-in-the-diatom-cyclotella-meneghiniana
#6
Anja Röding, Egbert Boekema, Claudia Büchel
Diatoms possess fucoxanthin chlorophyll proteins (FCP) as light-harvesting systems. These membrane intrinsic proteins bind fucoxanthin as major carotenoid and Chl c as accessory chlorophyll. The relatively high sequence homology to higher plant light-harvesting complex II gave rise to the assumption of a similar overall structure. From centric diatoms like Cyclotella meneghiniana, however, two major FCP complexes can be isolated. FCPa, composed of Fcp2 and Fcp6 subunits, was demonstrated to be trimeric, whereas FCPb, known to contain Fcp5 polypeptides, is of higher oligomeric state...
December 30, 2016: Photosynthesis Research
https://www.readbyqxmd.com/read/28034476/defining-cases-of-severe-pediatric-diarrhea-for-an-efficacy-trial-of-an-enterotoxigenic-escherichia-coli-etec-vaccine-report-on-an-international-workshop-washington-dc-march-2016
#7
Thomas F Wierzba, Alexandra Bourgis
Enterotoxigenic Escherichia coli (ETEC) causes severe acute watery diarrhea. No ETEC vaccine is available but candidates are in development, including ETVAX, an oral, whole-cell inactivated vaccine. ETVAX is being tested in a descending-age trial in Bangladesh. If found safe and immunogenic, investigators may test it for efficacy in children. Like oral rotavirus vaccines, we expect that ETVAX will be most effective at decreasing the incidence of moderate-to-severe ETEC episodes. Thus, for an efficacy trial outcome, it will be necessary to triage patients into moderate-to-severe versus mild disease...
December 26, 2016: Vaccine
https://www.readbyqxmd.com/read/28017275/trends-in-publications-in-radiology-journals-designated-as-relating-to-patient-centered-care
#8
Andrew B Rosenkrantz, James V Rawson
PURPOSE: To assess trends in publications in radiology journals designated as dealing with patient-centered care. METHODS: PubMed was searched for articles in radiology journals for which the article's record referenced patient-centered/patient-centric care. Among these, original research articles were identified and assigned major themes. Trends were assessed descriptively. RESULTS: A total of 115 articles in radiology journals designated as dealing with patient-centered care were identified, including 40 original research articles...
December 21, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28013343/warthin-tumor-within-the-superficial-lobe-of-the-parotid-gland-a-suggested-criterion-for-diagnosis
#9
Doron Sagiv, Robert L Witt, Eran Glikson, Jobran Mansour, Bruria Shalmon, Arkadi Yakirevitch, Michael Wolf, Eran E Alon, Guy Slonimsky, Yoav P Talmi
The location of Warthin tumor (WT) in the parotid gland impacts the surgical approach and may be indicative of the elusive origin of this intriguing entity. Location in the deep versus superficial lobe of the gland is not directly addressed when defining WT characteristics. Our observation, of rare occurrence of deep lobe WT, if at all, led to the current investigation. The study design is cohort study. This is a retrospective chart review of all patients undergoing parotidectomy for WT in two tertiary academic referral centers: the Sheba Medical Center (SMC), Israel, and the Christiana Care (CC), Newark, Delaware, USA...
December 24, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28011294/sea-ice-eukaryotes-of-the-gulf-of-finland-baltic-sea-and-evidence-for-herbivory-on-weakly-shade-adapted-ice-algae
#10
Markus Majaneva, Jaanika Blomster, Susann Müller, Riitta Autio, Sanna Majaneva, Kirsi Hyytiäinen, Satoshi Nagai, Janne-Markus Rintala
To determine community composition and physiological status of early spring sea-ice organisms, we collected sea-ice, slush and under-ice water samples from the Baltic Sea. We combined light microscopy, HPLC pigment analysis and pyrosequencing, and related the biomass and physiological status of sea-ice algae with the protistan community composition in a new way in the area. In terms of biomass, centric diatoms including a distinct Melosira arctica bloom in the upper intermediate section of the fast ice, dinoflagellates, euglenoids and the cyanobacterium Aphanizomenon sp...
October 24, 2016: European Journal of Protistology
https://www.readbyqxmd.com/read/28001287/mental-health-and-the-transgender-population
#11
Tamar C Carmel, Laura Erickson-Schroth
Although research into the physical and mental health disparities faced by transgender and gender nonconforming (TGNC) populations is becoming more popular, historically it has been limited. It is now recognized that TGNC people experience disproportionate rates of negative mental health outcomes relative to both their gender-normative, heterosexual peers, as well as their gender-normative lesbian, gay, and bisexual (LGB) peers. The theoretical basis of current transgender mental health research is rooted in the Minority Stress Model, which postulates that we live in a hetero-centric, gender-normative society that stigmatizes and discriminates against lesbian, gay, bisexual, and transgender (LGBT) people, subjecting them to chronic stress (Hendricks & Testa, 2012; Meyer, 1995)...
December 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/27993004/toward-the-rational-design-of-novel-noncentrosymmetric-materials-factors-influencing-the-framework-structures
#12
Kang Min Ok
Solid-state materials with extended structures have revealed many interesting structure-related characteristics. Among many, materials crystallizing in noncentrosymmetric (NCS) space groups have attracted massive attention attributable to a variety of superb functional properties such as ferroelectricity, pyroelectricity, piezoelectricity, and nonlinear optical (NLO) properties. In fact, the characteristics are pivotal to many industrial applications such as laser systems, optical communications, photolithography, energy harvesting, detectors, and memories...
December 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27976707/a-pathway-centric-view-of-spatial-proximity-in-the-3d-nucleome-across-cell-lines
#13
Hiren Karathia, Carl Kingsford, Michelle Girvan, Sridhar Hannenhalli
In various contexts, spatially proximal genes have been shown to be functionally related. However, the extent to which spatial proximity of genes in a pathway contributes to the pathway's context-specific activity is not known. Leveraging Hi-C data in six human cell-lines, we show that spatial proximity of genes in a pathway is highly correlated with the pathway's context-specific expression and function. Furthermore, spatial proximity of pathway genes correlates with interactions of their protein products, and the specific pathway genes that are proximal to one another tend to occupy higher levels in the regulatory hierarchy...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27971911/patient-centricity-patient-related-programs-in-the-german-healthcare-environment
#14
R Schwarz, M Freiberg, J Sprick, J Thiele
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27955884/pharmacogenetics-guided-analgesics-in-major-abdominal-surgery-further-benefits-within-an-enhanced-recovery-protocol
#15
Anthony J Senagore, Bradley J Champagne, Eslam Dosokey, Justin Brady, Scott R Steele, Harry L Reynolds, Sharon L Stein, Conor P Delaney
OBJECTIVE: Effective, narcotic sparing analgesia is a major component of Enhanced Recovery Protocols (ERP), however the risk of poor analgesia and opioid related side effects (ORADE) remains an issue related to poor outcomes and satisfaction, and is strongly related to the risk of narcotic dependence after surgery. A variety of genes can impact narcotic and non-steroidal (NSAID) drug efficacy including: the CYP family (drug metabolism-narcotics and NSAID), or COMT/ABCB1/OPRM1 (functional receptor and transport activity for analgesia vs side effects)...
November 22, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27935518/the-idea-of-uniform-change-is-it-time-to-revisit-a-central-tenet-of-rose-s-strategy-of-preventive-medicine
#16
Fahad Razak, George Davey Smith, S V Subramanian
A mean-centric view of populations, whereby a change in the mean of a health variable at the population level is assumed to result in uniform change across the distribution, is a core component of Geoffrey Rose's concept of the "population strategy" to disease prevention. This idea also has a critical role in Rose's observation that individuals who are considered abnormal or sick (the rightward tail of the distribution) and those who are considered normal (the center) are very closely related, and that true preventive medicine must focus on shifting the normal or average...
December 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27935091/fabrication-of-complete-dentures-in-three-visits-using-existing-prosthesis-a-simplified-technique-for-geriatric-patients
#17
Rahul S Kulkarni, Ravindra S Pawar
Complete edentulism often limits patients' ability to masticate and perform other oral functions, resulting in a reduction of oral-health-related quality of life. Although the two-implant mandibular overdenture may be considered as a minimum standard of treatment of complete edentulism, patients often prefer conventional complete dentures due to cost and surgical procedures related to implant supported dentures. Many complete denture patients may have limited access to dental care due to socioeconomic or health issues, hence there is a need in simplification of complete denture fabrication...
December 9, 2016: Special Care in Dentistry
https://www.readbyqxmd.com/read/27933523/integrative-functional-genomics-for-systems-genetics-in-geneweaver-org
#18
Jason A Bubier, Michael A Langston, Erich J Baker, Elissa J Chesler
The abundance of existing functional genomics studies permits an integrative approach to interpreting and resolving the results of diverse systems genetics studies. However, a major challenge lies in assembling and harmonizing heterogeneous data sets across species for facile comparison to the positional candidate genes and coexpression networks that come from systems genetic studies. GeneWeaver is an online database and suite of tools at www.geneweaver.org that allows for fast aggregation and analysis of gene set-centric data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27916279/insights-from-preclinical-choice-models-on-treating-drug-addiction
#19
REVIEW
Matthew L Banks, S Stevens Negus
Substance-use disorders are a global public health problem that arises from behavioral misallocation between drug use and more adaptive behaviors maintained by nondrug alternatives (e.g., food or money). Preclinical drug self-administration procedures that incorporate a concurrently available nondrug reinforcer (e.g., food) provide translationally relevant and distinct dependent measures of behavioral allocation (i.e., to assess the relative reinforcing efficacy of the drug) and behavioral rate (i.e., to assess motor competence)...
December 1, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27912990/cancer-rehabilitation-an-overview-of-current-need-delivery-models-and-levels-of-care
#20
REVIEW
Andrea L Cheville, Karen Mustian, Kerri Winters-Stone, David S Zucker, Gail L Gamble, Catherine M Alfano
The relevance of cancer rehabilitation as a public health issue grows steadily as cancer incidence, survival, and mean patient age increase. Reported rates of physical impairment and disability are already high, prior to the anticipated influx of aged cancer survivors. Despite the high prevalence of cancer-related disablement, treatment rates, even for readily remediable physical impairments, are as low as 1-2%. In addition to low referral rates, a challenge to patient-centric cancer rehabilitation is a fractured system that requires multiple visits to a range of specialists to address even a single issue, and cancer survivors generally have several...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
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