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https://www.readbyqxmd.com/read/28549478/gladiator-a-global-approach-for-elucidating-disease-modules
#1
Yael Silberberg, Martin Kupiec, Roded Sharan
BACKGROUND: Understanding the genetic basis of disease is an important challenge in biology and medicine. The observation that disease-related proteins often interact with one another has motivated numerous network-based approaches for deciphering disease mechanisms. In particular, protein-protein interaction networks were successfully used to illuminate disease modules, i.e., interacting proteins working in concert to drive a disease. The identification of these modules can further our understanding of disease mechanisms...
May 26, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28547865/re-imagining-alzheimer-s-disease-the-diminishing-importance-of-amyloid-and-a-glimpse-of-what-lies-ahead
#2
REVIEW
Kai-Hei Tse, Karl Herrup
Many have criticized the amyloid cascade hypothesis of Alzheimer's disease for its inconsistencies and failures to either accurately predict disease symptoms or guide the development of productive therapies. In addition to criticisms, however, we believe that the field would benefit from having alternative narratives and disease models that can either replace or function alongside of an amyloid-centric view of Alzheimer's. This review is an attempt to meet that need. We offer three experimentally verified amyloid-independent mechanisms, each of which plausibly contributes substantially to the etiology of Alzheimer's disease: loss of DNA integrity, faulty cell cycle regulation, regression of myelination...
May 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28546099/accuracy-of-pedicle-screw-placement-in-posterior-lumbosacral-instrumentation-by-computer-tomography-evaluation-a-multi-centric-retrospective-clinical-study
#3
Tianming Yu, Shuang Mi, Yuansong He, Zhenwu Zhang, Wenjie Dai, Jiqing Tian, Zhenghua Hong, Shunwu Fan, Fengdong Zhao
BACKGROUND: Pedicle screw misplacement rates are relatively high with fluoroscopically guided techniques. However, breach rates in the 5th lumbar and the 1st sacral spines in conventional operations have not been specifically concerned because of their broad cross sections. It's a retrospective study to evaluate the accuracy and safety of pedicle screw placement in posterior lumbosacral instrumentation under CT scan with reconstruction. MATERIALS AND METHODS: 401 patients were evaluated under CT scan with reconstruction in 3 hospitals by 2 professional observers after posterior lumbosacral instrumentation including 152 3rd lumbar spines (L3), 219 4th lumbar spines (L4), 270 5th lumbar spines (L5) and 95 1st sacral spines (S1) with screws placed...
May 22, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28545132/proteomics-investigation-of-oscc-specific-salivary-biomarkers-in-a-hungarian-population-highlights-the-importance-of-identification-of-population-tailored-biomarkers
#4
Éva Csősz, Péter Lábiscsák, Gergő Kalló, Bernadett Márkus, Miklós Emri, Adrienn Szabó, Ildikó Tar, József Tőzsér, Csongor Kiss, Ildikó Márton
Oral squamous cell carcinoma (OSCC) accounting for about 90% of malignant oral lesions is the 6th most common malignancy worldwide. Diagnostic delay may contribute to dismal survival rate therefore, there is a need for developing specific and sensitive biomarkers to improve early detection. Hungarian population occupies the top places of statistics regarding OSCC incidence and mortality figures therefore, we aimed at finding potential salivary protein biomarkers suitable for the Hungarian population. In this study we investigated 14 proteins which were previously reported as significantly elevated in saliva of patients with OSCC...
2017: PloS One
https://www.readbyqxmd.com/read/28529704/towards-a-systems-approach-for-chronic-diseases-based-on-health-state-modeling
#5
Michael Rebhan
Rising pressure from chronic diseases means that we need to learn how to deal with challenges at a different level, including the use of systems approaches that better connect across fragments, such as disciplines, stakeholders, institutions, and technologies. By learning from progress in leading areas of health innovation (including oncology and AIDS), as well as complementary indications (Alzheimer's disease), I try to extract the most enabling innovation paradigms, and discuss their extension to additional areas of application within a systems approach...
2017: F1000Research
https://www.readbyqxmd.com/read/28514347/-clinical-and-diagnostic-rationale-for-the-final-stage-of-orthodontic-treatment
#6
O V Dudnik, A A Mamedov, A M Dybov, V V Kharke
The aim of the study was to improve the efficiency of the final stage of orthodontic treatment. The study included 32 patients divided into two groups of 16. Orthodontic treatment was performed using a bracket system active self-ligation straight arc technique with step adjustment anthropometric quantitative evaluation system (The ABO Model Grading System). Centric occlusion and centric relation were analyzed at baseline and after treatment by mandible position indicator MPI (Mandibular Position Indicator)...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28495956/sharing-of-genes-and-pathways-across-complex-phenotypes-a-multilevel-genome-wide-analysis
#7
Hongsheng Gui, Johnny S Kwan, Pak C Sham, Stacey S Cherny, Miaoxin Li
Evidence from genome-wide association studies (GWAS) suggest that pleiotropic effects on human complex phenotypes are very common. Recently an atlas of genetic correlations among complex phenotypes has broadened our understanding of human diseases and traits. Here we examine genetic overlap, from a gene-centric perspective, among the same 24 phenotypes previously investigated for genetic correlations. After adopting the multilevel pipeline (freely available at http://grass.cgs.hku.hk/limx/kgg/) that includes intragenic single nucleotide polymorphisms (SNPs), genes and gene-sets to estimate genetic similarities across phenotypes, large amount of sharing for several biologically related phenotypes is confirmed...
May 11, 2017: Genetics
https://www.readbyqxmd.com/read/28493914/take-me-where-i-want-to-go-institutional-prestige-advisor-sponsorship-and-academic-career-placement-preferences
#8
Diogo L Pinheiro, Julia Melkers, Sunni Newton
Placement in prestigious research institutions for STEM (science, technology, engineering, and mathematics) PhD recipients is generally considered to be optimal. Yet some doctoral recipients are not interested in intensive research careers and instead seek alternative careers, outside but also within academe (for example teaching positions in Liberal Arts Schools). Recent attention to non-academic pathways has expanded our understanding of alternative PhD careers. However, career preferences and placements are also nuanced along the academic pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28490816/rethinking-sexual-citizenship
#9
Diane Richardson
Over the last two decades sexuality has emerged as a key theme in debates about citizenship, leading to the development of the concept of sexual citizenship. This article reviews this literature and identifies four main areas of critical framing: work that contests the significance of sexuality to citizenship; critiques that focus on the possibilities and limitations of mobilising the language of citizenship in sexual politics; analyses of sexual citizenship in relation to nationalisms and border making; and literature that critically examines western constructions of sexuality and sexual politics underpinning understandings of sexual citizenship...
April 2017: Sociology
https://www.readbyqxmd.com/read/28490244/-investigating-the-efficacy-of-nutrition-therapy-for-outpatients-with-inflammatory-bowel-disease
#10
Andrea Molnár, Ágnes Anna Csontos, Sarolta Dakó, Rita Hencz, Dániel Áron Anton, Erzsébet Pálfi, Pál Miheller
INTRODUCTION: Inflammatory bowel diseases can cause malnutrition (due to inflammatory cytokine production, catabolic states after surgery, restricted diet), which is difficult to treat by nutritional therapy. AIM: Investigating the efficacy of nutrition therapy. METHOD: Combined malnutrition risk screening (questionnaires and body composition analysis), at the beginning of the research and after a 1 year period. RESULTS: 205 patients were screened, 82 were malnourished...
May 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28481627/outcomes-after-percutaneous-reduction-and-fixation-of-low-energy-lisfranc-injuries
#11
Michael Vosbikian, Joseph T O'Neil, Christine Piper, Ronald Huang, Steven M Raikin
BACKGROUND: Lisfranc injuries are often missed initially or not anatomically reduced, leading to midfoot collapse, arthrosis, and pain. Operative management of these injuries is also fraught with complications, particularly with respect to the soft tissues. Wound dehiscence and infection are not uncommon. The goal of this study was to analyze the outcomes of a minimally invasive technique in reduction and percutaneous fixation of low-energy minimally displaced Lisfranc injuries and determine if it is a safe alternative to more traditional, open approaches...
May 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28479569/a-web-based-tool-to-enhance-monitoring-and-retention-in-care-for-tuberculosis-affected-patients
#12
Barbara Giannini, Niccolò Riccardi, Antonio Di Biagio, Giovanni Cenderello, Mauro Giacomini
Tuberculosis (TB) is responsible for a global epidemic. TB treatment requires long-term therapy usually with multiple drugs, which have potential side effects and interactions that may influence patients' adherence to treatment. The TB Ge network is a multi-centric web based platform that collects clinical information of TB affected patients to increase their support and retention in care. The system stores the list of all tuberculosis episodes for each patient with the related data, starting from the first visit including follow-ups clinical evaluations, laboratory tests, imaging and therapies...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28475181/a-systematic-review-to-assess-the-treat-and-extend-dosing-regimen-for-neovascular-age-related-macular-degeneration-using-ranibizumab
#13
REVIEW
S R Rufai, H Almuhtaseb, R M Paul, B L Stuart, T Kendrick, H Lee, A J Lotery
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Monthly or as-needed (PRN) dosing strategies of intravitreal ranibizumab have been established as efficacious treatment options for neovascular AMD. More recently, the 'treat-and-extend' dosing regimen (TREX) is being adopted in clinical practice as it represents a patient-centric and economical option, reducing treatment burden by extending injection intervals when possible. However, the efficacy of TREX using ranibizumab monotherapy remains to be defined...
May 5, 2017: Eye
https://www.readbyqxmd.com/read/28469608/genome-centric-analysis-of-a-thermophilic-and-cellulolytic-bacterial-consortium-derived-from-composting
#14
Leandro N Lemos, Roberta V Pereira, Ronaldo B Quaggio, Layla F Martins, Livia M S Moura, Amanda R da Silva, Luciana P Antunes, Aline M da Silva, João C Setubal
Microbial consortia selected from complex lignocellulolytic microbial communities are promising alternatives to deconstruct plant waste, since synergistic action of different enzymes is required for full degradation of plant biomass in biorefining applications. Culture enrichment also facilitates the study of interactions among consortium members, and can be a good source of novel microbial species. Here, we used a sample from a plant waste composting operation in the São Paulo Zoo (Brazil) as inoculum to obtain a thermophilic aerobic consortium enriched through multiple passages at 60°C in carboxymethylcellulose as sole carbon source...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28461533/tackling-patient-centricity-a-report-from-the-grappa-2016-annual-meeting
#15
Niti Goel, Denis O'Sullivan, Ingrid Steinkoenig, Jana James, Chris A Lindsay, Laura C Coates, John Latella, Alexis Ogdie, Jeffrey Chau, Heidi Bertheussen, Willemina Campbell
In line with the global trend to have disease-related organizations be more patient-centric in their approach, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) has made substantial progress incorporating patient research partners (PRP) into psoriatic arthritis and psoriasis research. Herein we summarize the involvement of PRP at the GRAPPA 2016 annual meeting. Plans for future PRP engagement were also discussed.
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28461520/prologue-2016-annual-meeting-of-the-group-for-research-and-assessment-of-psoriasis-and-psoriatic-arthritis-grappa
#16
Philip S Helliwell, Dafna D Gladman, Alice B Gottlieb
The 2016 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) was held in Miami, Florida, USA, and attended by rheumatologists, dermatologists, and representatives of biopharmaceutical companies and patient groups. As in previous years, GRAPPA members held a symposium for trainees to discuss their research in psoriatic disease with experts in the field. A strategic planning session was convened by the Steering Committee this year to review the work of GRAPPA since its inception in 2003...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28459247/conservative-functional-and-esthetic-rehabilitation-of-severe-palatal-erosion-class-iv-using-modified-dahl-approach
#17
Aliasger Tunkiwala, Rajeev Chitguppi
This article demonstrates the clinical application of biomechanical and occlusal principles to conservatively provide optimal clinical outcomes in restoring an eroded anterior dentition. The authors manage a challenging case involving limited palatal clearance (ie, deep bite) coupled with palatal erosion and wear by combining the centric relation (CR) and Dahl principles to create anterior interocclusal space to reduce the need for more invasive palatal reduction. The combined use of adhesive restorations-resin composites on the palatal surface and indirect porcelain veneers on the facial/incisal surfaces-through enamel and dentin bonding helped optimize esthetic and functional/biomechanical aspects...
May 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28457361/robot-assisted-harvesting-of-kidneys-for-transplantation-and-global-complications-for-the-donor
#18
A Giacomoni, L Centonze, S Di Sandro, A Lauterio, A L Ciravegna, V Buscemi, F Ferla, M Tripepi, G Concone, R De Carlis, G Colussi, M Gregorini, L De Carlis
INTRODUCTION: Robot-assisted kidney harvesting from living donors is feasible and safe. We report the results of a mono-centric experience relative to 98 consecutive robotic nephrectomies with emphasis on global donor complications. MATERIALS AND METHODS: This is a retrospective cohort study. Donors underwent robot-assisted kidney harvesting. The preferred kidney was the left one even in the presence of vascular anomalies. In the first cases we used a robotic hand-assisted technique, then the totally robotic technique, and finally the modified totally robot-assisted technique...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28455113/a-synopsis-of-brown-adipose-tissue-imaging-modalities-for-clinical-research
#19
REVIEW
L Sun, J Yan, L Sun, S S Velan, M K S Leow
Body weight gain results from a chronic excess of energy intake over energy expenditure. Accentuating endogenous energy expenditure has been accorded considerable attention ever since the presence of brown adipose tissue (BAT) in adult humans was recognized, given that BAT is known to increase energy expenditure via thermogenesis. Besides classic BAT, significant strides in our understanding of inducible brown adipocytes have been made regarding its development and function. While it is ideal to study BAT histologically, its relatively inaccessible anatomical locations and the inherent risks associated with biopsy preclude invasive techniques to evaluate BAT on a routine basis...
April 25, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28454800/rationale-and-design-of-family-based-approach-in-a-minority-community-integrating-systems-biology-for-promotion-of-health-familia
#20
Sameer Bansilal, Rajesh Vedanthan, Jason C Kovacic, Ana Victoria Soto, Jacqueline Latina, Johan L M Björkegren, Risa Jaslow, Maribel Santana, Samantha Sartori, Chiara Giannarelli, Venkatesh Mani, Roger Hajjar, Eric Schadt, Andrew Kasarskis, Zahi A Fayad, Valentin Fuster
BACKGROUND: The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease...
May 2017: American Heart Journal
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