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https://www.readbyqxmd.com/read/29164356/investigating-the-impacts-of-treated-effluent-discharge-on-coastal-water-health-visakhapatnam-sw-coast-of-bay-of-bengal-india
#1
Aziz Ur Rahman Shaik, Haimanti Biswas, N Surendra Babu, N P C Reddy, Z A Ansari
The present study investigated the impacts of treated effluent discharge on physicochemical and biological properties of coastal waters from three pharmaceuticals situated along the coast of Visakhapatnam (SW Bay of Bengal). Seawater samples were collected (during the months of December 2013, March 2014 and April 2014) from different sampling locations (Chippada (CHP), Tikkavanipalem (TKP) and Nakkapalli (NKP)) at 0- and 30-m depths within 2-km radius (0.5 km = inner, 1 km = middle and 2 km = outer sampling circles) from the marine outfall points...
November 21, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29161192/patient-preferences-in-subglottic-stenosis-treatment-a-discrete-choice-experiment
#2
Matthew R Naunheim, Margaret L Naunheim, Vinay K Rathi, Ramon A Franco, Mark G Shrime, Phillip C Song
Objectives Subglottic stenosis can be addressed with several different surgical techniques, but patient preferences for these treatment modalities are poorly understood. Economic methods are increasingly being used to understand how patients make decisions. The objective of this pilot study was to assess preferences in subglottic stenosis treatment using patient-centric stated preference techniques. Study Design Discrete choice experiment (DCE). Setting Academic research facility. Subjects and Methods A computer-based DCE was administered in a monitored setting to volunteers from the general population...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29158326/women-and-substance-use-a-qualitative-study-on-sexual-and-reproductive-health-of-women-who-use-drugs-in-delhi-india
#3
Vartika Sharma, Avina Sarna, Waimar Tun, Lopamudra Ray Saraswati, Ibou Thior, Ira Madan, Stanley Luchters
OBJECTIVES: To explore contextual factors that increase vulnerabilities to negative sexual and reproductive health (SRH) outcomes and possible differences in SRH-related behaviours and the needs of women who use drugs (WUD) through non-injecting and injecting routes. DESIGN: Qualitative study design using semi-structured in-depth interviews. PARTICIPANTS: Twenty women who injected drugs in the past 3 months and 28 women who reported using drugs through non-injecting routes in the past 1 month...
November 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29156360/does-the-15-item-geriatric-depression-scale-function-differently-in-old-people-with-different-levels-of-cognitive-functioning
#4
Francesca Chiesi, Caterina Primi, Martina Pigliautile, Marta Baroni, Sara Ercolani, Lucia Paolacci, Virginia Boccardi, Patrizia Mecocci
BACKGROUND: The 15-item version of the Geriatric Depression Scale (GDS-15) is widely employed to screen depression among elderly but little is known about the scale functioning in cognitively impaired individuals when compared to normal ones. The aim of the current study is to investigate Differential Item Functioning (DIF) across groups of older people that differ in terms of cognitive functioning applying Item Response Theory (IRT)-based analyses. METHODS: Data from an Italian multi-centric clinical-based study on cognitive impairment and dementia in old people were employed (N = 1903; Age: M = 77...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29151795/the-influence-of-occlusal-stabilization-appliances-on-cervical-dystonia-symptoms
#5
Camelia Navrotchi, Mîndra Eugenia Badea
Objectives: The aim of this study was to assess the therapeutic efficiency of the occlusal stabilization appliance (OSA) in patients with cervical dystonia (CD). Methods: The study included 11 patients aged between 29 and 80 years, 7 women and 4 men, diagnosed with primary CD. The patients underwent an extra- and intra-oral clinical examination, followed by para-clinical examinations, necessary for the specifications of the OSA. The following data were recorded: demographic parameters, CD duration, management of the disease, dental impression, recording of the centric relationship, recording of the position of the upper jaw with the facial bow...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29150246/development-of-the-autosomal-dominant-polycystic-kidney-disease-impact-scale-a-new-health-related-quality-of-life-instrument
#6
Dorothee Oberdhan, Jason C Cole, Holly B Krasa, Rebecca Cheng, Frank S Czerwiec, Ron D Hays, Arlene B Chapman, Ronald D Perrone
BACKGROUND: The impact of autosomal dominant polycystic kidney disease (ADPKD) on health-related quality of life (HRQoL) is not well understood due to a lack of instruments specific to the condition. STUDY DESIGN: Content for a new self-administered patient-reported outcome (PRO) questionnaire to assess ADPKD-related HRQoL was developed through clinical expert and patient focus group discussions. The new PRO instrument was administered to study patients with ADPKD to evaluate its reliability and validity...
November 14, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29142906/hierarchical-modeling-of-patient-and-physician-determinants-of-blood-pressure-outcomes-in-hypertensive-patients-with-and-without-diabetes-pooled-analysis-of-six-observational-valsartan-studies-with-15-282-evaluable-patients
#7
Noha Ashy, Thanh-Nga Nguyen, Kris Denhaerynck, Mahdi Gharaibeh, Abdulaziz Alhossan, Stefaan Vancayzeele, Heidi Brié, Ann Aerts, Karen MacDonald, Ivo Abraham
We pooled data from 6 valsartan-related studies including 3,658 diabetic and 11,624 nondiabetic patients to evaluate blood pressure (BP) outcomes after approximately 90 days of second- or later-line valsartan treatment. Hierarchical linear and logistic regressions were applied to identify determinants of BP outcomes. Similar reductions in BP values and similar BP control rates were achieved in both groups after approximately 90 days of therapy. The modeling analyses identified several common and different patient- and physician-related determinants of BP outcomes for both groups, many of which are modifiable or clinically manageable...
2017: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29141839/patient-health-record-systems-scope-and-functionalities-literature-review-and-future-directions
#8
REVIEW
Lina Bouayad, Anna Ialynytchev, Balaji Padmanabhan
BACKGROUND: A new generation of user-centric information systems is emerging in health care as patient health record (PHR) systems. These systems create a platform supporting the new vision of health services that empowers patients and enables patient-provider communication, with the goal of improving health outcomes and reducing costs. This evolution has generated new sets of data and capabilities, providing opportunities and challenges at the user, system, and industry levels. OBJECTIVE: The objective of our study was to assess PHR data types and functionalities through a review of the literature to inform the health care informatics community, and to provide recommendations for PHR design, research, and practice...
November 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29134064/cancer-and-intercellular-cooperation
#9
REVIEW
Marta Bertolaso, Anna Maria Dieli
The major transitions approach in evolutionary biology has shown that the intercellular cooperation that characterizes multicellular organisms would never have emerged without some kind of multilevel selection. Relying on this view, the Evolutionary Somatic view of cancer considers cancer as a breakdown of intercellular cooperation and as a loss of the balance between selection processes that take place at different levels of organization (particularly single cell and individual organism). This seems an elegant unifying framework for healthy organism, carcinogenesis, tumour proliferation, metastasis and other phenomena such as ageing...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#10
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29119010/epigenetic-impact-of-endocrine-disrupting-chemicals-on-lipid-homeostasis-and-atherosclerosis-a-pregnane-x-receptor-centric-view
#11
Robert N Helsley, Changcheng Zhou
Despite the major advances in developing diagnostic techniques and effective treatments, atherosclerotic cardiovascular disease (CVD) is still the leading cause of mortality and morbidity worldwide. While considerable progress has been achieved to identify gene variations and environmental factors that contribute to CVD, much less is known about the role of "gene-environment interactions" in predisposing individuals to CVD. Our chemical environment has significantly changed in the last few decades, and there are more than 100,000 synthetic chemicals in the market...
October 1, 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29108591/solamente-mexicanos-patterns-and-sources-of-hispanic-diversity-in-u-s-metropolitan-areas
#12
Barrett A Lee, Michael J R Martin, Matthew Hall
Rapid Hispanic growth has been a major source of increasing ethnoracial diversity in the United States. However, diversity within the Hispanic population is frequently obscured by the tendency to lump all Latinos together. Our study examines Hispanic diversity at the local level, drawing insights from the Mexican dominance, Caribbean-centric settlement, spatial assimilation, and economic opportunity perspectives. Measures of the magnitude and structure of Hispanic origin-group diversity during the 1990-2010 period are constructed for 363 metropolitan areas based on each area's shares of Mexicans, Puerto Ricans, Cubans, Dominicans, Salvadorans, Guatemalans, Colombians, and 'others'...
November 2017: Social Science Research
https://www.readbyqxmd.com/read/29106817/application-of-the-aace-ace-advanced-framework-for-the-diagnosis-of-obesity-and-cardiometabolic-disease-staging-in-a-general-population-from-three-regions-of-venezuela-the-vemsols-study-results
#13
Ramfis Nieto-Martínez, Juan P González-Rivas, Eunice Ugel, Imperia Brajkovich, Alejandro Risquez, W Timothy Garvey, Jeffrey I Mechanick
OBJECTIVE: To determine the prevalence of obesity according to the AACE/ACE framework based on a complications-centric model with further application of the Cardiometabolic Disease Staging (CMDS) system in Venezuelan population. METHODS: 1,320 adults were randomly selected from 3 regions. AACE/ACE framework definitions: overweight: body mass index (BMI) 25 to 29.9 kg/m(2) and no obesity-related complications (ORC); obesity stage 0: BMI ≥ 30 and no ORC; stage 1: BMI ≥ 25 and one or more mild-to-moderate ORC; and stage 2: BMI ≥ 25 and one or more severe ORC...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29104219/smart-collaborative-caching-for-information-centric-iot-in-fog-computing
#14
Fei Song, Zheng-Yang Ai, Jun-Jie Li, Giovanni Pau, Mario Collotta, Ilsun You, Hong-Ke Zhang
The significant changes enabled by the fog computing had demonstrated that Internet of Things (IoT) urgently needs more evolutional reforms. Limited by the inflexible design philosophy; the traditional structure of a network is hard to meet the latest demands. However, Information-Centric Networking (ICN) is a promising option to bridge and cover these enormous gaps. In this paper, a Smart Collaborative Caching (SCC) scheme is established by leveraging high-level ICN principles for IoT within fog computing paradigm...
November 1, 2017: Sensors
https://www.readbyqxmd.com/read/29077866/are-there-any-relations-among-transplant-centre-volume-surgical-technique-and-anatomy-for-donor-graft-selection-ten-year-multicentric-italian-experience-on-mini-invasive-living-donor-nephrectomy
#15
Matteo Ravaioli, Enzo Capocasale, Lucrezia Furian, Vanessa De Pace, Maurizio Iaria, Gionata Spagnoletti, Maria Paola Salerno, Alessandro Giacomoni, Luciano De Carlis, Caterina Di Bella, Nguefouet Momo Rostand, Luigino Boschiero, Giovanni Pasquale, Andrea Bosio, Andrea Collini, Mario Carmellini, Andrea Airoldi, Gianmarco Bondonno, Pasquale Ditonno, Stefano Vittorio Impedovo, Claudio Beretta, Antenore Giussani, Carlo Socci, Danilo Carlo Parolini, Massimo Abelli, Elena Ticozzelli, Umberto Baccarani, Gian Luigi Adani, Flavia Caputo, Barbara Buscemi, Mauro Frongia, Andrea Solinas, Salvatore Gruttadauria, Marco Spada, Antonio Daniele Pinna, Jacopo Romagnoli
Background: Selection of the right or left living donor kidney for transplantation is influenced by many variables. In the present multi centric study including 21 Italian transplant centres, we evaluated whether centre volume or surgical technique may influence the selection process. Methods: Intra- and perioperative donor data, donor kidney function, and recipient and graft survival were collected among 693 mini-invasive living donor nephrectomies performed from 2002 to 2014...
October 25, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29061646/kras-mutation-and-consensus-molecular-subtypes-2-and-3-are-independently-associated-with-reduced-immune-infiltration-and-reactivity-in-colorectal-cancer
#16
Neeraj Lal, Brian S White, Ghaleb Goussous, Oliver J Pickles, Michael Mason, Andrew D Beggs, Philippe Taniere, Benjamin E Willcox, Justin Guinney, Gary Middleton
PURPOSE: KRAS mutation is a common canonical mutation in CRC, found at differing frequencies in all Consensus Molecular Subtypes (CMS). The independent immunobiological impacts of RAS mutation and CMS are unknown. Thus, we explored the immunobiological effects of KRAS mutation across the CMS spectrum. EXPERIMENTAL DESIGN: Transcriptional analysis of immune genes/signatures was performed with RNA-seq using The Cancer Genome Atlas (TCGA) and the KFSYSCC data set. Multivariate analysis included KRAS status, CMS, tumour location, MSI status, and neoantigen load...
October 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29061117/diatom-flagellar-genes-and-their-expression-during-sexual-reproduction-in-leptocylindrus-danicus
#17
Deepak Nanjappa, Remo Sanges, Maria I Ferrante, Adriana Zingone
BACKGROUND: Flagella have been lost in the vegetative phase of the diatom life cycle, but they are still present in male gametes of centric species, thereby representing a hallmark of sexual reproduction. This process, besides maintaining and creating new genetic diversity, in diatoms is also fundamental to restore the maximum cell size following its reduction during vegetative division. Nevertheless, sexual reproduction has been demonstrated in a limited number of diatom species, while our understanding of its different phases and of their genetic control is scarce...
October 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29059488/stereoelectroencephalography-and-surgical-outcome-in-polymicrogyria-related-epilepsy-a-multicentric-study
#18
Louis Georges Maillard, Laura Tassi, Fabrice Bartolomei, Hélène Catenoix, François Dubeau, William Szurhaj, Philippe Kahane, Anca Nica, Petr Marusic, Ioana Mindruta, Francine Chassoux, Georgia Ramantani
OBJECTIVE: We aimed to (1) assess the concordance between various polymicrogyria (PMG) types and the associated epileptogenic zone (EZ), as defined by stereoelectroencephalography (SEEG), and (2) determine the postsurgical seizure outcome in PMG-related drug-resistant epilepsy. METHODS: We retrospectively analyzed 58 cases: 49 had SEEG and 39 corticectomy or hemispherotomy. RESULTS: Mean age at SEEG or surgery was 28.3 years (range, 2-50)...
October 23, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29057508/impact-of-antiviral-prophylaxis-in-adults-ebv-seronegative-kidney-recipients-on-early-and-late-ptld-onset-a-retrospective-cohort-study
#19
Simon Ville, Berthe-Marie Imbert-Marcille, Marianne Coste-Burel, Claire Garandeau, Aurélie Meurette, Diego Cantarovitch, Magali Giral, Maryvonne Hourmant, Gilles Blancho, Jacques Dantal
Post-transplantation lympho-proliferative disorder (PTLD) pathogenesis is related to EBV infection. Mismatch with the donor (EBV D+/R-) is the main risk factor for both early PTLD (< 1 year post transplantation) and late (> 1 year). In these at-risk patients, the role of antiviral prophylaxis for preventing PTLD remains controversial. We analysed the impact of antiviral drugs given to prevent CMV disease in a mono-centric retrospective cohort of 73 adult kidney or kidney-pancreas EBV seronegative recipients, transplanted between 01/01/2000 and 01/01/2016...
October 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29053274/from-racemic-metal-nanoparticles-to-optically-pure-enantiomers-in-one-pot
#20
Huayan Yang, Juanzhu Yan, Yu Wang, Guocheng Deng, Haifeng Su, Xiaojing Zhao, Chaofa Xu, Boon K Teo, Nanfeng Zheng
A general strategy, using mixed ligands, is utilized to synthesize atomically precise, intrinsically chiral nanocluster [Ag78(DPPP)6(SR)42] (Ag78) where DPPP is the achiral 1,3-bis(diphenyphosphino)propane and SR = SPhCF3. Ag78 crystallizes as racemates in a centric space group. Using chiral diphosphines BDPP = 2,4-bis(diphenylphosphino)pentane, the enantiomeric pair [Ag78(R/S-BDPP)6(SR)42] can be prepared with 100% optical purity. The chiral diphosphines gives rise to, separately, two asymmetric surface coordination motifs composed of tetrahedral R3PAg(SR)3 moieties...
November 15, 2017: Journal of the American Chemical Society
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