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https://www.readbyqxmd.com/read/28441101/male-centric-and-female-centric-pornography-consumption-relationship-with-sex-life-and-attitudes-in-young-adults
#1
Ilisha M French, Lisa Dawn Hamilton
Pornography availability has increased in recent years and while there is plenty of speculation about its effects, empirical investigation about how porn influences our lives has yielded mixed results. Additionally, few studies have addressed the effects of specific pornography characteristics. Past research has shown that male-centric pornography can be related to negative outcomes, while female-centric pornography is related to more positive outcomes, particularly in women. The present survey study examined the relationship between pornography characteristics (male- and female-centric) and the self-reported attitudes and sexual experiences of men and women...
April 25, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28423861/a-digital-framework-to-support-providers-and-patients-in-diabetes-related-behavior-modification
#2
Samina Abidi, Michael Vallis, Helena Piccinini-Vallis, Syed Ali Imran, Syed Sibte Raza Abidi
We present Diabetes Web-Centric Information and Support Environment (D-WISE) that features: (a) Decision support tool to assist family physicians to administer Behavior Modification (BM) strategies to patients; and (b) Patient BM application that offers BM strategies and motivational interventions to engage patients. We take a knowledge management approach, using semantic web technologies, to model the social cognition theory constructs, Canadian diabetes guidelines and BM protocols used locally, in terms of a BM ontology that drives the BM decision support to physicians and BM strategy adherence monitoring and messaging to patients...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28414473/an-alter-centric-perspective-on-employee-innovation-the-importance-of-alters-creative-self-efficacy-and-network-structure
#3
Travis J Grosser, Vijaya Venkataramani, Giuseppe Joe Labianca
While most social network studies of employee innovation behavior examine the focal employees' ("egos'") network structure, we employ an alter-centric perspective to study the personal characteristics of employees' network contacts-their "alters"-to better understand employee innovation. Specifically, we examine how the creative self-efficacy (CSE) and innovation behavior of employees' social network contacts affects their ability to generate and implement novel ideas. Hypotheses were tested using a sample of 144 employees in a U...
April 17, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28413623/glutamate-plasticity-woven-through-the-progression-to-alcohol-use-disorder-a-multi-circuit-perspective
#4
REVIEW
Lara Hwa, Joyce Besheer, Thomas Kash
Glutamate signaling in the brain is one of the most studied targets in the alcohol research field. Here, we report the current understanding of how the excitatory neurotransmitter glutamate, its receptors, and its transporters are involved in low, episodic, and heavy alcohol use. Specific animal behavior protocols can be used to assess these different drinking levels, including two-bottle choice, operant self-administration, drinking in the dark, the alcohol deprivation effect, intermittent access to alcohol, and chronic intermittent ethanol vapor inhalation...
2017: F1000Research
https://www.readbyqxmd.com/read/28409625/privileged-structural-motif-detection-and-analysis-using-generative-topographic-maps
#5
Shilva Kayastha, Dragos Horvath, Erik Gilberg, Michael Gütschow, Jürgen Bajorath, Alexandre Varnek
Identification of "privileged structural motifs" associated with specific target families is of particular importance for designing novel bioactive compounds. Here, we demonstrate that they can be extracted from a data distribution represented on a two-dimensional map obtained by Generative Topographic Mapping (GTM) . In GTM, structurally related molecules are grouped together on the map. Zones of the map preferentially populated by target-specific compounds were delineated, which helped to capture common substructures on the basis of which these compounds were grouped together by the GTM...
April 14, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28408956/a-controversy-with-respect-to-occlusion
#6
REVIEW
Shunji Fukushima
There are very little controversies on occlusion in healthy individuals, where centric relation is regarded as the criterion for assessing the present occlusion and also for establishing a new occlusal relationship between the upper and the lower jaws. On the other hand, the occlusal position in patients with deformed condyles still remains to be clarified. In this review, the effectiveness and limits of centric relation in these patients are discussed. In addition, the muscle induced occlusal positions, such as the muscular position and the terminal positions of habitual closing movements, are suggested as a substitution for centric relation...
August 2016: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28404159/a-microbiota-centric-view-of-diseases-of-the-upper-gastrointestinal-tract
#7
REVIEW
Gerardo Nardone, Debora Compare, Alba Rocco
The distinctive anatomy and physiology of the upper gastrointestinal tract and the difficulty of obtaining samples led to the theory that it was bacteria free. However, multiomics studies are indicating otherwise. Although influenced by both oral and gastric bacteria, the resident microbial ecosystem in the oesophagus is dominated by Streptococcus. A shift from Gram-positive to Gram-negative bacteria occurs in oesophagitis and Barrett's oesophagus, and this shift might be involved in the pathogenesis of oesophageal adenocarcinoma...
April 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28402653/host-cell-protein-profiling-by-targeted-and-untargeted-analysis-of-data-independent-acquisition-mass-spectrometry-data-with-parallel-reaction-monitoring-verification
#8
Simion Kreimer, Yuanwei Gao, Somak Ray, Mi Jin, Zhijun Tan, Nesredin A Mussa, Li Tao, Zhengjian Li, Alexander R Ivanov, Barry L Karger
Host cell proteins (HCPs) are process-related impurities of biopharmaceuticals that remain at trace levels despite multiple stages of downstream purification. Currently, there is interest in implementing LC-MS in biopharmaceutical HCP profiling alongside conventional ELISA, because individual species can be identified and quantitated. Conventional data-dependent LC-MS is hampered by the low concentration of HCP-derived peptides, which are 5-6 orders of magnitude less abundant than the biopharmaceutical-derived peptides...
April 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28378193/regression-based-approaches-to-patient-centered-cost-effectiveness-analysis
#9
Daisuke Goto, Ya-Chen Tina Shih, Pascal Lecomte, Melvin Olson, Chukwukadibia Udeze, Yujin Park, C Daniel Mullins
Achieving comprehensive patient centricity in cost-effectiveness analyses (CEAs) requires a statistical approach that accounts for patients' preferences and clinical and demographic characteristics. Increased availability and accessibility of patient-level health-related utility data from clinical trials or observational database provide enhanced opportunities to conduct more patient-centered CEA. Regression-based approaches that incorporate patient-level data hold great promise for enhancing CEAs to be more patient centered; this paper provides guidance regarding two CEA approaches that apply regression-based approaches utilizing patient-level health-related utility and costs data...
April 4, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28376512/improving-the-evaluation-and-diagnosis-of-clinically-significant-prostate-cancer
#10
Oleksandr N Kryvenko, Jonathan I Epstein
PURPOSE OF REVIEW: This chapter describes important changes in the clinical practice and pathological interpretation of prostate cancer (PCa) that stratify PCa into insignificant and significant disease to allow for better patient management and treatment decisions. RECENT FINDINGS: Among the most important changes over the last half a decade has been the change in PCa grading. A new grading system has been developed that is more patient-centric with more accurate stratification according to risk of disease progression...
May 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28368127/is-centric-relation-always-the-position-of-choice-for-tmds-case-report-of-how-tmd-and-airway-dimension-may-be-associated
#11
William E Harrell, Tim Tatum, Mike Koslin
Centric occlusion (CO) and centric relation (CR) have been controversial topics in dentistry for almost 100 years. The concept of CR emerged due to the search for a reproducible mandibular position that would enable the prosthodontic rehabilitation of patients needing denture treatment. The following case study is unique because of 2 questions. Which mandibular treatment splint position (CR or CO) was appropriate for the initial and eventual final treatment of this patient for her temporomandibular disorder/myofascial pain and dysfunction? Also, how might the mandibular position of CR and CO affect the size and shape of the airway? The airway's size and shape is important as it relates to sleep-disordered breathing and potentially leading to obstructive sleep apnea later in life...
April 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28365915/autoimmune-pancreatitis
#12
REVIEW
Shounak Majumder, Naoki Takahashi, Suresh T Chari
Autoimmune pancreatitis (AIP) is a chronic fibroinflammatory disease of the pancreas that belongs to the spectrum of immunoglobulin G-subclass4-related diseases (IgG4-RD) and typically presents with obstructive jaundice. Idiopathic duct-centric pancreatitis (IDCP) is a closely related but distinct disease that mimics AIP radiologically but manifests clinically most commonly as recurrent acute pancreatitis in young individuals with concurrent inflammatory bowel disease. IgG4 levels are often elevated in AIP and normal in IDCP...
April 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28365140/deregulation-of-crtcs-in-aging-and-age-related-disease-risk
#13
REVIEW
Caroline C Escoubas, Carlos G Silva-García, William B Mair
Advances in public health in the past century have seen a sharp increase in human life expectancy. With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor for multiple chronic conditions that often occur simultaneously within a single individual. An alternative to disease-centric therapeutic approaches is that of 'geroscience', which aims to define molecular mechanisms that link age to overall disease risk. One such mechanism is deregulation of CREB-regulated transcriptional coactivators (CRTCs)...
March 29, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28361102/gene-centric-analysis-implicates-nuclear-encoded-mitochondrial-protein-gene-variants-in-migraine-susceptibility
#14
Shani Stuart, Miles C Benton, David A Eccles, Heidi G Sutherland, Larisa M Haupt, Rodney A Lea, Lyn R Griffiths
BACKGROUND: Migraine is a common neurological disorder which affects a large proportion of the population. The Norfolk Island population is a genetically isolated population and is an ideal discovery cohort for genetic variants involved in complex disease susceptibility given the reduced genetic and environmental heterogeneity. Given that the majority of proteins responsible for mitochondrial function are nuclear encoded, this study aimed to investigate the role of Nuclear Encoded Mitochondrial Protein (NEMP) genes in relation to migraine susceptibility...
March 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28358052/hived-a-knowledgebase-for-differentially-expressed-human-genes-and-proteins-during-hiv-infection-replication-and-latency
#15
Chen Li, Sri H Ramarathinam, Jerico Revote, Georges Khoury, Jiangning Song, Anthony W Purcell
Measuring the altered gene expression level and identifying differentially expressed genes/proteins during HIV infection, replication and latency is fundamental for broadening our understanding of the mechanisms of HIV infection and T-cell dysfunction. Such studies are crucial for developing effective strategies for virus eradication from the body. Inspired by the availability and enrichment of gene expression data during HIV infection, replication and latency, in this study, we proposed a novel compendium termed HIVed (HIV expression database; http://hivlatency...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28343340/a-lake-centric-geospatial-database-to-guide-research-and-inform-management-decisions-in-an-arctic-watershed-in-northern-alaska-experiencing-climate-and-land-use-changes
#16
Benjamin M Jones, Christopher D Arp, Matthew S Whitman, Debora Nigro, Ingmar Nitze, John Beaver, Anne Gädeke, Callie Zuck, Anna Liljedahl, Ronald Daanen, Eric Torvinen, Stacey Fritz, Guido Grosse
Lakes are dominant and diverse landscape features in the Arctic, but conventional land cover classification schemes typically map them as a single uniform class. Here, we present a detailed lake-centric geospatial database for an Arctic watershed in northern Alaska. We developed a GIS dataset consisting of 4362 lakes that provides information on lake morphometry, hydrologic connectivity, surface area dynamics, surrounding terrestrial ecotypes, and other important conditions describing Arctic lakes. Analyzing the geospatial database relative to fish and bird survey data shows relations to lake depth and hydrologic connectivity, which are being used to guide research and aid in the management of aquatic resources in the National Petroleum Reserve in Alaska...
March 25, 2017: Ambio
https://www.readbyqxmd.com/read/28336805/what-is-data-ethics
#17
Luciano Floridi, Mariarosaria Taddeo
This theme issue has the founding ambition of landscaping data ethics as a new branch of ethics that studies and evaluates moral problems related to data (including generation, recording, curation, processing, dissemination, sharing and use), algorithms (including artificial intelligence, artificial agents, machine learning and robots) and corresponding practices (including responsible innovation, programming, hacking and professional codes), in order to formulate and support morally good solutions (e.g. right conducts or right values)...
December 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28336477/a-novel-semantic-representation-for-eligibility-criteria-in-clinical-trials
#18
Efthymios Chondrogiannis, Vassiliki Andronikou, Anastasios Tagaris, Efstathios Karanastasis, Theodora Varvarigou, Masatsugu Tsuji
Eligibility Criteria (EC) comprise an important part of a clinical study, being determinant of its cost, duration and overall success. Their formal, computer-processable description can significantly improve clinical trial design and conduction by enabling their intelligent processing, replicability and linkability with other data. For EC representation purposes, related standards were investigated, along with published literature. Moreover, a considerable number of clinicaltrials.gov studies was analyzed in collaboration with clinical experts for the determination and classification of parameters of clinical research importance...
March 21, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28334930/rcas-an-rna-centric-annotation-system-for-transcriptome-wide-regions-of-interest
#19
Bora Uyar, Dilmurat Yusuf, Ricardo Wurmus, Nikolaus Rajewsky, Uwe Ohler, Altuna Akalin
In the field of RNA, the technologies for studying the transcriptome have created a tremendous potential for deciphering the puzzles of the RNA biology. Along with the excitement, the unprecedented volume of RNA related omics data is creating great challenges in bioinformatics analyses. Here, we present the RNA Centric Annotation System (RCAS), an R package, which is designed to ease the process of creating gene-centric annotations and analysis for the genomic regions of interest obtained from various RNA-based omics technologies...
February 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28329385/importance-of-combined-left-atrial-size-and-estimated-pulmonary-pressure-for-clinical-outcome-in-patients-presenting-with-heart-failure-with-preserved-ejection-fraction
#20
Erwan Donal, Lars H Lund, Emmanuel Oger, Christian Bosseau, Amélie Reynaud, Camilla Hage, Elodie Drouet, J-Claude Daubert, Cecila Linde
Aims: Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with various phenotypes and outcomes. The prognostic relevance of echocardiography and the E/e' ratio has previously been reported. We sought to study in addition, the value of estimated pulmonary pressure and left atrial size for diagnosing and determining a prognosis for HFpEF-patients in a prospective multi-centric cohort. Methods and results: Patients with an acute-HF event accompanied with NT-proBNP >300 pg/mL (BNP >100 pg/mL) and LVEF >45% were included (n = 237) and clinically reassessed using echo-Doppler after 4-8 weeks of HF treatment as part of the prospective KaRen HFpEF study...
March 4, 2017: European Heart Journal Cardiovascular Imaging
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