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https://www.readbyqxmd.com/read/29332647/social-support-a-key-factor-for-adherence-to-multidrug-resistant-tuberculosis-treatment
#1
R D Deshmukh, D J Dhande, K S Sachdeva, A N Sreenivas, A M V Kumar, M Parmar
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is emerging as a major public health problem globally. Treatment success rates in MDR-TB across the globe are not encouraging as completing MDR-TB treatment successfully is challenging due to high proportion of lost to follow up. METHODS: Using qualitative methods and grounded theory approach, in-depth interviews were conducted with MDR-TB patients and treatment providers. The social cognitive framework was explored as a way to guide understanding of the factors affecting treatment adherence among MDR-TB patients...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29323730/biochemical-and-molecular-study-on-interleukin-1%C3%AE-gene-expression-and-relation-of-single-nucleotide-polymorphism-in-promoter-region-with-type-2-diabetes-mellitus
#2
Safaa I Tayel, Eman Am Fouda, Elsayed I Elshayeb, Asmaa Ra Eldakamawy, Salah M El-Kousy
Interleukin-1β (IL-1β) assumes a centric role in the regulation of immune and inflammatory responses and thus has been recognized in immune mediated diseases like type 2 diabetes mellitus (T2DM). We aimed to investigate expressed level of IL-1β and its relation with IL-1β -511T > C polymorphism in T2DM patients. This study enrolled 80 subjects (50 patients with T2DM and 30 healthy control subjects). Laboratory investigations included fasting (FBG) and 2h postprandial blood sugar (2h PBG), HBA1c, lipid profile and renal function tests...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29321019/a-qualitative-study-on-coping-behaviors-and-influencing-factors-among-mothers-in-japan-raising-children-under-three-years-old-while-experiencing-physical-and-mental-subjective-symptoms
#3
Misato Kaso, Kikuko Miyazaki, Takeo Nakayama
BACKGROUND: No studies illustrating the coping behaviors of mothers experiencing physical and mental subjective symptoms, or the factors that contribute to these behaviors, have been investigated. Therefore, the present study sought to develop a conceptual framework on the coping behaviors and contributing factors of mothers experiencing physical and mental subjective symptoms. METHODS: This qualitative study involved theoretical sampling and semi-structured interviews of mothers who were raising children under 3 years of age in Japan and had experienced physical and mental subjective symptoms since giving birth...
January 10, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29304251/the-role-of-leadership-in-people-centred-health-systems-a-sub-national-study-in-the-gambia
#4
Simukai Chigudu, Momodou Jasseh, Umberto d'Alessandro, Tumani Corrah, Adama Demba, Julie Balen
Recently, increasing attention has been given to behavioural and relational aspects of the people who both define and shape health systems, placing them at the core. A growing refrain includes the assertion that important decisions determining health system performance, including agenda setting, policy formulation and policy implementation, are made by people. Within this actor-oriented approach, good leadership has been identified as a key contributing factor in health systems strengthening. However, leadership remains ill-defined and under-researched, especially in resource-limited settings, and understanding the links between leadership and health outcomes remains a challenge...
January 1, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29289333/understanding-neurodevelopmental-disorders-the-promise-of-regulatory-variation-in-the-3-utrome
#5
REVIEW
Kai A Wanke, Paolo Devanna, Sonja C Vernes
Neurodevelopmental disorders have a strong genetic component, but despite widespread efforts, the specific genetic factors underlying these disorders remain undefined for a large proportion of affected individuals. Given the accessibility of exome sequencing, this problem has thus far been addressed from a protein-centric standpoint; however, protein-coding regions only make up ∼1% to 2% of the human genome. With the advent of whole genome sequencing we are in the midst of a paradigm shift as it is now possible to interrogate the entire sequence of the human genome (coding and noncoding) to fill in the missing heritability of complex disorders...
November 14, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29285407/designing-a-pain-management-protocol-for-craniotomy-a-narrative-review-and-consideration-of-promising-practices
#6
REVIEW
Susana Vacas, Barbara Van de Wiele
Background: Craniotomy is a relatively common surgical procedure with a high incidence of postoperative pain. Development of standardized pain management and enhanced recovery after surgery (ERAS) protocols are necessary and crucial to optimize outcomes and patient satisfaction and reduce health care costs. Methods: This work is based upon a literature search of published manuscripts (between 1996 and 2017) from Pubmed, Cochrane Central Register, and Google Scholar...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29280508/does-freeze-all-policy-affect-ivf-outcomes-in-poor-responders
#7
Matheus Roque, Marcello Valle, Marcos Sampaio, Selmo Geber
OBJECTIVES: To evaluate whether the freeze-all strategy affects in vitro fertilization (IVF) outcomes in poor ovarian responders following the Bologna criteria. METHODS: We performed a retrospective cohort study conducted between January 2012 and December 2016. A total of 433 poor responders (per the Bologna criteria) fulfilled the inclusion/exclusion criteria and were included in the study, with 277 patients included in the fresh group and 156 in the freeze-all group...
December 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29278544/self-management-strategies-in-chronic-obstructive-pulmonary-disease-a-first-step-toward-personalized-medicine
#8
Miriam Barrecheguren, Jean Bourbeau
PURPOSE OF REVIEW: Self-management has gained increased relevance in the management of chronic obstructive pulmonary disease patients. The heterogeneity in self-management interventions has complicated the development of recommendations for clinical practice. In this review, we present the latest findings regarding conceptual definition, effectiveness of self-management interventions and self-management strategies in chronic obstructive pulmonary disease as a first step toward personalized medicine: what, how and to whom? RECENT FINDINGS: Self-management interventions have shown benefits in improving health-related quality of life and reducing hospital admissions...
December 22, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29277587/the-use-of-flow-diverter-in-ruptured-dissecting-intracranial-aneurysms-of-the-posterior-circulation
#9
Volker Maus, Anastasios Mpotsaris, Franziska Dorn, Markus Möhlenbruch, Jan Borggrefe, Pantelis Stavrinou, Nuran Abdullayev, Utako Birgit Barnikol, Thomas Liebig, Christoph Kabbasch
OBJECTIVE: Acute dissecting aneurysms of the posterior circulation are a rare cause of SAH. Established endovascular treatment options include PAO and stent-assisted coiling, but appear to be associated with an increased risk of ischemic stroke. Vessel reconstruction with flow-diverters is an alternative treatment option, however, its safety and efficacy in the acute stage remains unclear. METHODS: Multi-centric retrospective analysis of 15 consecutive acutely ruptured dissecting posterior circulation aneurysms treated with flow-diverters...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29277111/the-value-of-motion-patient-reported-outcome-measures-are-correlated-with-range-of-motion-in-total-ankle-replacement
#10
Travis J Dekker, Kamran S Hamid, Andrew E Federer, John R Steele, Mark E Easley, James A Nunley, Samuel B Adams
BACKGROUND: The proposed benefit of total ankle replacement (TAR) over ankle fusion is preserved ankle motion, thus we hypothesized that an increase in range of motion (ROM) is positively correlated with validated patient-reported outcome measures (PROMs) in individuals receiving TAR. METHODS: Patients undergoing TAR at a single academic medical center between 2007 and 2013 were evaluated in this study. In addition to a minimum of 2-year follow-up, complete preoperative and postoperative outcome measures for the Foot and Ankle Disability Index (FADI), Short Musculoskeletal Function Assessment (SMFA) Bother and Function Indices, Visual Analog Scale (VAS), and 36-Item Short Form Health Survey (SF-36) were requisite for inclusion...
December 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29273574/consumer-adoption-of-future-mydata-based-preventive-ehealth-services-an-acceptance-model-and-survey-study
#11
Timo Koivumäki, Saara Pekkarinen, Minna Lappi, Jere Väisänen, Jouni Juntunen, Minna Pikkarainen
BACKGROUND: Constantly increasing health care costs have led countries and health care providers to the point where health care systems must be reinvented. Consequently, electronic health (eHealth) has recently received a great deal of attention in social sciences in the domain of Internet studies. However, only a fraction of these studies focuses on the acceptability of eHealth, making consumers' subjective evaluation an understudied field. This study will address this gap by focusing on the acceptance of MyData-based preventive eHealth services from the consumer point of view...
December 22, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29261665/molecular-recognition-and-packing-frustration-in-a-helical-protein
#12
Loan Huynh, Chris Neale, Régis Pomès, Hue Sun Chan
Biomolecular recognition entails attractive forces for the functional native states and discrimination against potential nonnative interactions that favor alternate stable configurations. The challenge posed by the competition of nonnative stabilization against native-centric forces is conceptualized as frustration. Experiment indicates that frustration is often minimal in evolved biological systems although nonnative possibilities are intuitively abundant. Much of the physical basis of minimal frustration in protein folding thus remains to be elucidated...
December 19, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29243678/the-relationship-between-pathological-wear-of-teeth-and-temporomandibular-joint-dysfunction
#13
Egle Mickeviciute, Ausra Baltrusaityte, Gaivile Pileicikiene
OBJECTIVE: Temporomandibular joint dysfunction (TMJD) is quite frequent pathology in population. In scientific literature pathological tooth wear (PTW) is listed among the predisposing factors of it. MATERIAL AND METHODS: During the survey 189 primary patients of dental department in polyclinic of Panevezys city were examined. According to the tooth wear degree 2 groups have been formed: control group (grade 0-1) withouth TMJ dysfunction; and experimental group (grade 2-4) with presumable TMJD...
2017: Stomatologija
https://www.readbyqxmd.com/read/29242996/personalized%C3%A2-health-monitoring%C3%A2-system-for-managing-well-being-in-rural-areas
#14
Prema Nedungadi, Akshay Jayakumar, Raghu Raman
Rural India lacks easy access to health practitioners and medical centers, depending instead on community health workers. In these areas, common ailments that are easy to manage with medicines, often lead to medical escalations and even fatalities due to lack of awareness and delayed diagnosis. The introduction of wearable health devices has made it easier to monitor health conditions and to connect doctors and patients in urban areas. However, existing initiatives have not succeeded in providing adequate health monitoring to rural and low-literate patients, as current methods are expensive, require consistent connectivity and expect literate users...
December 14, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29241881/ispor-code-of-ethics-2017-4th-edition
#15
Jessica Santos, Francis Palumbo, Elizabeth Molsen-David, Richard J Willke, Louise Binder, Michael Drummond, Anita Ho, William D Marder, Louise Parmenter, Gurmit Sandhu, Asrul A Shafie, David Thompson
As the leading health economics and outcomes research (HEOR) professional society, ISPOR has a responsibility to establish a uniform, harmonized international code for ethical conduct. ISPOR has updated its 2008 Code of Ethics to reflect the current research environment. This code addresses what is acceptable and unacceptable in research, from inception to the dissemination of its results. There are nine chapters: 1 - Introduction; 2 - Ethical Principles respect, beneficence and justice with reference to a non-exhaustive compilation of international, regional, and country-specific guidelines and standards; 3 - Scope HEOR definitions and how HEOR and the Code relate to other research fields; 4 - Research Design Considerations primary and secondary data related issues, e...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29239815/provider-recommendations-for-patient-reported-muscle-symptoms-on-statin-therapy-insights-from-the-understanding-statin-use-in-america-and-gaps-in-patient-education-survey
#16
Terry A Jacobson, Abdullah Khan, Kevin C Maki, Eliot A Brinton, Jerome D Cohen
BACKGROUND: Statin-associated muscle symptoms are reported by 10% to 29% of patients in clinical practice and are a major determinant of statin nonadherence, discontinuation, and switching. Little is known about what advice patients receive from their providers when dealing with these symptoms. OBJECTIVE: The objective of the study was to assess patient's reports of provider advice when experiencing new or worsened muscle symptoms while taking a statin. METHODS: Data were analyzed from the Understanding Statin Use in America and Gaps in Education survey, a self-administered internet-based survey of 10,138 adults with a reported history of high cholesterol and statin use...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29237241/the-p-patens-chromosome-scale-assembly-reveals-moss-genome-structure-and-evolution
#17
Daniel Lang, Kristian K Ullrich, Florent Murat, Jörg Fuchs, Jerry Jenkins, Fabian B Haas, Mathieu Piednoel, Heidrun Gundlach, Michiel Van Bel, Rabea Meyberg, Cristina Vives, Jordi Morata, Aikaterini Symeonidi, Manuel Hiss, Wellington Muchero, Yasuko Kamisugi, Omar Saleh, Guillaume Blanc, Eva L Decker, Nico van Gessel, Jane Grimwood, Richard D Hayes, Sean W Graham, Lee E Gunter, Stuart McDaniel, Sebastian N W Hoernstein, Anders Larsson, Fay-Wei Li, Pierre-Francois Perroud, Jeremy Phillips, Priya Ranjan, Daniel S Rokshar, Carl J Rothfels, Lucas Schneider, Shengqiang Shu, Dennis W Stevenson, Fritz Thümmler, Michael Tillich, Juan Carlos Villarreal A, Thomas Widiez, Gane Ka-Shu Wong, Ann Wymore, Yong Zhang, Andreas D Zimmer, Ralph S Quatrano, Klaus F X Mayer, David Goodstein, Josep M Casacuberta, Klaas Vandepoele, Ralf Reski, Andrew C Cuming, Jerry Tuskan, Florian Maumus, Jérome Salse, Jeremy Schmutz, Stefan A Rensing
The draft genome of the moss model, Physcomitrella patens, comprised approximately 2,000 unordered scaffolds. In order to enable analyses of genome structure and evolution we generated a chromosome-scale genome assembly using genetic linkage as well as (end) sequencing of long DNA fragments. We find that 57% of the genome comprises transposable elements (TEs), some of which may be actively transposing during the life cycle. Unlike in flowering plant genomes, gene- and TE-rich regions show an overall even distribution along the chromosomes...
December 13, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29229843/machine-learning-shows-association-between-genetic-variability-in-pparg-and-cerebral-connectivity-in-preterm-infants
#18
Michelle L Krishnan, Zi Wang, Paul Aljabar, Gareth Ball, Ghazala Mirza, Alka Saxena, Serena J Counsell, Joseph V Hajnal, Giovanni Montana, A David Edwards
Preterm infants show abnormal structural and functional brain development, and have a high risk of long-term neurocognitive problems. The molecular and cellular mechanisms involved are poorly understood, but novel methods now make it possible to address them by examining the relationship between common genetic variability and brain endophenotype. We addressed the hypothesis that variability in the Peroxisome Proliferator Activated Receptor (PPAR) pathway would be related to brain development. We employed machine learning in an unsupervised, unbiased, combined analysis of whole-brain diffusion tractography together with genomewide, single-nucleotide polymorphism (SNP)-based genotypes from a cohort of 272 preterm infants, using Sparse Reduced Rank Regression (sRRR) and correcting for ethnicity and age at birth and imaging...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29212925/done-in-100-ms-path-dependent-visuomotor-transformation-in-the-human-upper-limb
#19
Chao Gu, J Andrew Pruszynski, Paul L Gribble, Brian D Corneil
A core assumption underlying mental chronometry is that more complex tasks increase cortical processing, prolonging reaction times. Here we show that increases in task complexity alter the magnitude, rather than the latency, of the output for a circuit that rapidly transforms visual information into motor actions. We quantified visual stimulus-locked responses (SLRs), which are changes in upper limb muscle recruitment that evolve at a fixed latency ~100 ms after novel visual stimulus onset. First, we studied the underlying reference frame of the SLR, by dissociating initial eye and hand position...
December 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29208740/ecosystem-resilience-and-limitations-revealed-by-soil-bacterial-community-dynamics-in-a-bark-beetle-impacted-forest
#20
Kristin M Mikkelson, Brent M Brouillard, Chelsea M Bokman, Jonathan O Sharp
Forested ecosystems throughout the world are experiencing increases in the incidence and magnitude of insect-induced tree mortality with large ecologic ramifications. Interestingly, correlations between water quality and the extent of tree mortality in Colorado montane ecosystems suggest compensatory effects from adjacent live vegetation that mute responses in less severely impacted forests. To this end, we investigated whether the composition of the soil bacterial community and associated functionality beneath beetle-killed lodgepole pine was influenced by the extent of surrounding tree mortality...
December 5, 2017: MBio
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