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https://www.readbyqxmd.com/read/28719615/a-human-tissue-based-functional-assay-platform-to-evaluate-the-immune-function-impact-of-small-molecule-inhibitors-that-target-the-immune-system
#1
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune system to ameliorate disease also carry a risk of immunosuppression that could lead to adverse outcomes. Therefore, it is important to understand the 'immune fingerprint' of novel therapeutics as they relate to current and, clinically used immunological therapies to better understand their potential therapeutic benefit as well as immunosuppressive ability that might lead to adverse events such as infection risks and cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28713763/evaluation-of-three-different-processing-techniques-in-the-fabrication-of-complete-dentures
#2
Vamsi Krishna Chintalacheruvu, Rajasekaran Uttukuli Balraj, Lavanya Sireesha Putchala, Sreelekha Pachalla
AIMS AND OBJECTIVES: The objective of the present study is to compare the effectiveness of three different processing techniques and to find out the accuracy of processing techniques through number of occlusal interferences and increase in vertical dimension after denture processing. MATERIALS AND METHODS: A cross-sectional study was conducted on a sample of 18 patients indicated for complete denture fabrication was selected for the study and they were divided into three subgroups...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28708124/considerations-and-future-research-directions-for-e-cigarette-warnings-findings-from-expert-interviews
#3
Olivia A Wackowski, David Hammond, Richard J O'Connor, Andrew A Strasser, Cristine D Delnevo
Tobacco warning labels are important sources of risk information but research historically has been cigarette-centric. This qualitative study aimed to inform future direction and research on warnings for e-cigarettes. Between June and August 2016, we conducted interviews with 10 researchers with expertise in tobacco warning label research. Interviewees were registrants of a 2016 National Cancer Institute grantee meeting on tobacco warnings. Several participants agreed that the Food and Drug Administration's new nicotine addiction warning for e-cigarettes could be informative but that it might not resonate with young people...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28706470/structure-elucidation-of-metabolite-x17299-by-interpretation-of-mass-spectrometric-data
#4
Qibo Zhang, Lisa A Ford, Anne M Evans, Douglas R Toal
INTRODUCTION: A major bottleneck in metabolomic studies is metabolite identification from accurate mass spectrometric data. Metabolite x17299 was identified in plasma as an unknown in a metabolomic study using a compound-centric approach where the associated ion features of the compound were used to determine the true molecular mass. OBJECTIVES: The aim of this work is to elucidate the chemical structure of x17299, a new compound by de novo interpretation of mass spectrometric data...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28699547/lightweight-predicate-extraction-for-patient-level-cancer-information-and-ontology-development
#5
Muhammad Amith, Hsing-Yi Song, Yaoyun Zhang, Hua Xu, Cui Tao
BACKGROUND: Knowledge engineering for ontological knowledgebases is resource and time intensive. To alleviate these issues, especially for novices, automated tools from the natural language domain can assist in the development process of ontologies. We focus towards the development of ontologies for the public health domain and use patient-centric sources from MedlinePlus related to HPV-causing cancers. METHODS: This paper demonstrates the use of a lightweight open information extraction (OIE) tool to derive accurate knowledge triples that can lead to the seeding of an ontological knowledgebase...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28698312/approaches-for-extending-human-healthspan-from-antioxidants-to-healthspan-pharmacology
#6
REVIEW
Jan Gruber, Barry Halliwell
Dramatic increases in human lifespan and declining population growth are monumental achievements but these same achievements have also led to many societies today ageing at a faster rate than ever before. Extending healthy lifespan (healthspan) is a key translational challenge in this context. Disease-centric approaches to manage population ageing risk are adding years to life without adding health to these years. The growing consensus that ageing is driven by a limited number of interconnected processes suggests an alternative approach...
July 15, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28698311/proteomics-and-metabolomics-in-ageing-research-from-biomarkers-to-systems-biology
#7
REVIEW
Jessica M Hoffman, Yang Lyu, Scott D Pletcher, Daniel E L Promislow
Age is the single greatest risk factor for a wide range of diseases, and as the mean age of human populations grows steadily older, the impact of this risk factor grows as well. Laboratory studies on the basic biology of ageing have shed light on numerous genetic pathways that have strong effects on lifespan. However, we still do not know the degree to which the pathways that affect ageing in the lab also influence variation in rates of ageing and age-related disease in human populations. Similarly, despite considerable effort, we have yet to identify reliable and reproducible 'biomarkers', which are predictors of one's biological as opposed to chronological age...
July 15, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28696793/need-for-hyperlipidemia-management-policy-reform-in-china-learning-from-the-global-experience
#8
Wei Yu, Ruizhi Shi, Jim Li, Yong Lan, Qian Li, Shanlian Hu
OBJECTIVE: To evaluate the hyperlipidemia prevention programs and policies in different countries and highlight the need of reforming the hyperlipidemia prevention policies in China to lower the growing cardiovascular disease (CVD) risk. RESEARCH DESIGN AND METHODS: PubMed, Google Scholar and Cochrane were searched for global hyperlipidemia prevention policies. Government-funded policies pertaining to lipid management were considered for this review. For literature purpose, only those studies that evaluated the success of prevention policies on the basis of: i) achievement of hyperlipidemia targets; ii) improvement in CV risk reduction; and iii) outcomes with reduction in hyperlipidemia after implementation of the policy, were included...
July 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28693461/social-network-correlates-of-hiv-risk-related-behaviors-among-male-migrants-in-china
#9
Wenqing Wang, Kathryn E Muessig
BACKGROUND: Significant domestic and global research has focused on HIV risk among China's large internal migrant population. Much of this work takes an individual behavior approach while ignoring the critical role social networks play in shaping HIV risk. METHODS: Based on past studies among migrant men in China of yingchou activities (activities that build and reinforce social networks such as eating, drinking alcohol and patronizing commercial sex), we constructed ego-centric networks for a sample of 385 male migrants recruited from multiple worksites in Beijing...
May 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28692386/the-evolution-of-biosense-lessons-learned-and-future-directions
#10
Deborah W Gould, David Walker, Paula W Yoon
The BioSense program was launched in 2003 with the aim of establishing a nationwide integrated public health surveillance system for early detection and assessment of potential bioterrorism-related illness. The program has matured over the years from an initial Centers for Disease Control and Prevention-centric program to one focused on building syndromic surveillance capacity at the state and local level. The uses of syndromic surveillance have also evolved from an early focus on alerts for bioterrorism-related illness to situational awareness and response, to various hazardous events and disease outbreaks...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28685499/body-image-mediates-the-effect-of-cancer-related-stigmatization-on-depression-a-new-target-for-intervention
#11
Peter Esser, Anja Mehnert, Christoffer Johansen, Beate Hornemann, Andreas Dietz, Jochen Ernst
OBJECTIVE: Since cancer-related stigmatization is prevalent but difficult to change, research on its impact on psychological burden and intervening variables is needed. Therefore, we investigated the effect of stigmatization on depressive symptomatology and whether body image mediates this relationship. METHODS: This bi-centric study assessed patients of four major tumor entities. We measured stigmatization (SIS-D), depressive symptomatology (PHQ-9) and body image (FKB-20)...
July 6, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28671543/quality-and-innovation-redesigning-a-coordinated-and-connected-health-system
#12
Peter W Vaughan
Nova Scotia's consolidated health system was launched on April 1, 2015. This new approach to organizing health administration and services in the province arose out of necessity. When planning began, Nova Scotia was spending 41% of its annual budget on health services. In comparison to other provinces and territories, our per capita health-related spending was among the highest in the country, we had one of Canada's oldest populations and we had some of the worst health outcomes. Clearly, we could not continue to do the same things and expect different results...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/28658253/return-of-warm-conditions-in-the-southeastern-bering-sea-phytoplankton-fish
#13
Janet T Duffy-Anderson, Phyllis J Stabeno, Elizabeth C Siddon, Alex G Andrews, Daniel W Cooper, Lisa B Eisner, Edward V Farley, Colleen E Harpold, Ron A Heintz, David G Kimmel, Fletcher F Sewall, Adam H Spear, Ellen C Yasumishii
In 2014, the Bering Sea shifted back to warmer ocean temperatures (+2 oC above average), bringing concern for the potential for a new warm stanza and broad biological and ecological cascading effects. In 2015 and 2016 dedicated surveys were executed to study the progression of ocean heating and ecosystem response. We describe ecosystem response to multiple, consecutive years of ocean warming and offer perspective on the broader impacts. Ecosystem changes observed include reduced spring phytoplankton biomass over the southeast Bering Sea shelf relative to the north, lower abundances of large-bodied crustacean zooplankton taxa, and degraded feeding and body condition of age-0 walleye pollock...
2017: PloS One
https://www.readbyqxmd.com/read/28641552/a-review-of-the-psychometric-properties-and-use-of-the-rheumatoid-arthritis-quality-of-life-questionnaire-raqol-in-clinical-research
#14
Alice Heaney, Jessica Stepanous, Matthew Rouse, Stephen P McKenna
BACKGROUND: Several patient-reported outcome measures (PROMs) have been used in studies of Rheumatoid Arthritis (RA). Most of these assess health-related quality of life (HRQL). The exception is the Rheumatoid Arthritis Quality of Life questionnaire (RAQoL). This scale measures the impact of RA and its treatment from the patient's perspective, making it suitable for determining the value patients gain from interventions. OBJECTIVE: This review collates literature reporting on the efficacy of the RAQoL as a measure of patient value in clinical studies...
June 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28641097/long-term-complications-after-hematopoietic-cell-transplantation
#15
REVIEW
Navneet S Majhail
The prevalence of autologous and allogeneic hematopoietic cell transplantation (HCT) survivors continues to increase. Among patients whose disease remains in remission for the first 2-5years after transplantation, it is estimated that approximately 80-90% will be alive over the subsequent 10years. However, the relative mortality rates of such patients continue to remain higher than those of their general population peers, with late complications contributing to significant long-term morbidity and mortality...
June 13, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28641068/centric-relation-intercuspal-position-discrepancy-and-its-relationship-with-temporomandibular-disorders-a-systematic-review
#16
Antonio Jiménez-Silva, Julio Tobar-Reyes, Sheilah Vivanco-Coke, Eduardo Pastén-Castro, Hernán Palomino-Montenegro
OBJECTIVE: The objective of this study is to assess the relationship between centric relation-intercuspal position discrepancy (CR-ICP discrepancy) and temporomandibular disorders (TMDs), by systematically reviewing the literature. MATERIALS AND METHODS: A systematic research was performed between 1960 and 2016 based on electronic databases: PubMed, Cochrane Library, Medline, Embase, Scopus, EBSCOhost, BIREME, Lilacs and Scielo, including all languages. Analytical observational clinical studies were identified...
June 22, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28639686/tempor%C3%A3-re-anhebung-der-vertikaldimension-mit-komposit-in-einem-vereinfachten-direkten-spritzgussverfahren
#17
Jürgen Manhart
The comprehensive dental rehabilitation of complex prosthetic cases is often associated with increasing occlusal vertical dimension and transferring horizontal mandibular position in centric relation. The newly defined position of the mandibula should be functionally and esthetically evaluated for a longer time period before irreversible measures are performed. This case report discusses in detail a time-saving and economic direct method for increasing occlusal vertical dimension with long-term provisional composite restorations using a simplified injection molding technique and illustrates the complete intraoral and laboratory workflow...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28639123/a-multispecies-approach-to-co-sleeping-integrating-human-animal-co-sleeping-practices-into-our-understanding-of-human-sleep
#18
Bradley P Smith, Peta C Hazelton, Kirrilly R Thompson, Joshua L Trigg, Hayley C Etherton, Sarah L Blunden
Human sleeping arrangements have evolved over time and differ across cultures. The majority of adults share their bed at one time or another with a partner or child, and many also sleep with pets. In fact, around half of dog and cat owners report sharing a bed or bedroom with their pet(s). However, interspecies co-sleeping has been trivialized in the literature relative to interpersonal or human-human co-sleeping, receiving little attention from an interdisciplinary psychological perspective. In this paper, we provide a historical outline of the "civilizing process" that has led to current sociocultural conceptions of sleep as an individual, private function crucial for the functioning of society and the health of individuals...
September 2017: Human Nature: An Interdisciplinary Biosocial Perspective
https://www.readbyqxmd.com/read/28633796/cotton-osteotomy-in-flatfoot-reconstruction-a-case-report-highlighting-surgical-technique-and-modified-incision-to-protect-the%C3%A2-medial-dorsal-cutaneous-nerve
#19
Troy J Boffeli, Katherine R Schnell
The Cotton osteotomy or opening wedge medial cuneiform osteotomy is a useful adjunctive flatfoot reconstructive procedure that is rarely performed in isolation. The Cotton procedure is relatively quick to perform and effectively corrects forefoot varus deformity after rearfoot fusion or osteotomy to achieve a rectus forefoot to rearfoot relationship. Proper patient selection is critical, because preoperative findings of medial column joint instability, concomitant hallux valgus deformity, or degenerative joint disease of the medial column might be better treated with arthrodesis of the naviculocuneiform or first tarsometatarsal joints...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28630414/predicting-the-reliability-of-drug-target-interaction-predictions-with-maximum-coverage-of-target-space
#20
Antonio Peón, Stefan Naulaerts, Pedro J Ballester
Many computational methods to predict the macromolecular targets of small organic molecules have been presented to date. Despite progress, target prediction methods still have important limitations. For example, the most accurate methods implicitly restrict their predictions to a relatively small number of targets, are not systematically validated on drugs (whose targets are harder to predict than those of non-drug molecules) and often lack a reliability score associated with each predicted target. Here we present a systematic validation of ligand-centric target prediction methods on a set of clinical drugs...
June 19, 2017: Scientific Reports
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