keyword
MENU ▼
Read by QxMD icon Read
search

centric relation

keyword
https://www.readbyqxmd.com/read/29774413/alterations-in-histone-acetylation-following-exposure-to-60-co-%C3%AE-rays-and-their-relationship-with-chromosome-damage-in-human-lymphoblastoid-cells
#1
Xue-Lei Tian, Xue Lu, Jiang-Bin Feng, Tian-Jing Cai, Shuang Li, Mei Tian, Qing-Jie Liu
Chromosome damage is related to DNA damage and erroneous repair. It can cause cell dysfunction and ultimately induce carcinogenesis. Histone acetylation is crucial for regulating chromatin structure and DNA damage repair. Ionizing radiation (IR) can alter histone acetylation. However, variations in histone acetylation in response to IR exposure and the relationship between histone acetylation and IR-induced chromosome damage remains unclear. Hence, this study investigated the variation in the total acetylation levels of H3 and H4 in human lymphocytes exposed to 0-2 Gy 60 Co γ-rays...
May 17, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29773677/the-relative-resistance-of-children-to-sepsis-mortality-from-pathways-to-drug-candidates
#2
Rose B Joachim, Gabriel M Altschuler, John N Hutchinson, Hector R Wong, Winston A Hide, Lester Kobzik
Attempts to develop drugs that address sepsis based on leads developed in animal models have failed. We sought to identify leads based on human data by exploiting a natural experiment: the relative resistance of children to mortality from severe infections and sepsis. Using public datasets, we identified key differences in pathway activity (Pathprint) in blood transcriptome profiles of septic adults and children. To find drugs that could promote beneficial (child) pathways or inhibit harmful (adult) ones, we built an in silico pathway drug network (PDN) using expression correlation between drug, disease, and pathway gene signatures across 58,475 microarrays...
May 17, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/29768477/faster-clinical-response-to-the-onset-of-adverse-events-a-wearable-metacognitive-attention-aid-for-nurse-triage-of-clinical-alarms
#3
Daniel C McFarlane, Alexa K Doig, James A Agutter, Lara M Brewer, Noah D Syroid, Ranjeev Mittu
OBJECTIVE: This study evaluates the potential for improving patient safety by introducing a metacognitive attention aid that enables clinicians to more easily access and use existing alarm/alert information. It is hypothesized that this introduction will enable clinicians to easily triage alarm/alert events and quickly recognize emergent opportunities to adapt care delivery. The resulting faster response to clinically important alarms/alerts has the potential to prevent adverse events and reduce healthcare costs...
2018: PloS One
https://www.readbyqxmd.com/read/29768053/quality-of-life-and-patients-expectations-in-soft-tissue-sarcoma
#4
Robin L Jones, Axel Le Cesne
Assessment of health-related quality of life (HRQoL) is essential for holistic care. Greater efforts are required to incorporate HRQoL measures into clinical trials and daily practice. Considerable HRQoL data are available for localized soft tissue sarcomas (STS), particularly in the orthopedic setting. In future, HRQoL is expected to become increasingly important in the evaluation of palliative therapy in advanced STS. A patient-centric approach is advocated for STS management. Greater awareness of STS by nonspecialist clinicians, and timely referral to specialized sarcoma reference centers, is crucial for patient welfare...
May 2018: Future Oncology
https://www.readbyqxmd.com/read/29755917/sharing-is-caring-minimizing-the-disruption-with-palliative-care
#5
EDITORIAL
Abd Moain Abu Dabrh, Robert P Shannon, Richard J Presutti
There is an upward trend incidence of multiple chronic life-limiting conditions with a well-documented associated impact on patients and their caregivers. When patients approach the end of life, they are often faced with a challenging multidimensional burden while navigating a complex health care system. Patients and families/caregivers are faced with daily decisions, often with little or no frame of reference or medical knowledge. The "what, how, when, and where" puzzle during this challenging time can be overwhelming for patients and their families, and when clinicians do not contemplate this associated workload's impact on patients and caregivers' capacity for self-care, patients and caregivers scramble to find compensatory solutions, often putting their health care at lower priority...
March 13, 2018: Curēus
https://www.readbyqxmd.com/read/29741237/-walking-the-tightrope-the-role-of-peer-support-workers-in-facilitating-consumers-participation-in-decision-making
#6
Michelle Cleary, Toby Raeburn, Phil Escott, Sancia West, Violeta Lopez
In adult mental health services, the participation of consumers is essential. The aim of this study was to explore the challenges faced by peer support workers when involving mental health consumers in decision-making about their care and the strategies they employed to overcome these challenges so as to improve mental health consumers' participation in decision-making and recovery. Semi-structured individual interviews were conducted with six peer support workers currently employed in psychiatric hospitals and/or community mental health systems...
May 9, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29731741/a-large-scale-comparative-metagenomic-study-reveals-the-functional-interactions-in-six-bloom-forming-microcystis-epibiont-communities
#7
Qi Li, Feibi Lin, Chen Yang, Juanping Wang, Yan Lin, Mengyuan Shen, Min S Park, Tao Li, Jindong Zhao
Cyanobacterial blooms are worldwide issues of societal concern and scientific interest. Lake Taihu and Lake Dianchi, two of the largest lakes in China, have been suffering from annual Microcystis -based blooms over the past two decades. These two eutrophic lakes differ in both nutrient load and environmental parameters, where Microcystis microbiota consisting of different Microcystis morphospecies and associated bacteria (epibionts) have dominated. We conducted a comprehensive metagenomic study that analyzed species diversity, community structure, functional components, metabolic pathways and networks to investigate functional interactions among the members of six Microcystis -epibiont communities in these two lakes...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29722276/sustained-reductions-in-migraine-days-moderate-to-severe-headache-days-and-days-with-acute-medication-use-for-hfem-and-cm-patients-taking-fremanezumab-post-hoc-analyses-from-phase-2-trials
#8
Rashmi B Halker Singh, Ernesto Aycardi, Marcelo E Bigal, Pippa S Loupe, Mirna McDonald, David W Dodick
Background In phase 2 and 3 studies, fremanezumab, a monoclonal CGRP antibody, was an effective preventive treatment for high-frequency episodic migraine (HFEM) and chronic migraine (CM). Objective Post-hoc analyses evaluated population-wise 50%, 75% and 100% responder rates, and the extent to which individual responders sustained a 50%, 75% and 100% reduction in migraine days, moderate-to-severe (M/S) headache days and days of acute medication use during all three treatment months of the fremanezumab phase 2 studies...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29714694/centric-relation-records-for-implant-overdentures
#9
Roger A Solow
No abstract text is available yet for this article.
May 2018: General Dentistry
https://www.readbyqxmd.com/read/29713376/genome-centric-metatranscriptomes-and-ecological-roles-of-the-active-microbial-populations-during-cellulosic-biomass-anaerobic-digestion
#10
Yangyang Jia, Siu-Kin Ng, Hongyuan Lu, Mingwei Cai, Patrick K H Lee
Background: Although anaerobic digestion for biogas production is used worldwide in treatment processes to recover energy from carbon-rich waste such as cellulosic biomass, the activities and interactions among the microbial populations that perform anaerobic digestion deserve further investigations, especially at the population genome level. To understand the cellulosic biomass-degrading potentials in two full-scale digesters, this study examined five methanogenic enrichment cultures derived from the digesters that anaerobically digested cellulose or xylan for more than 2 years under 35 or 55 °C conditions...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29706222/using-a-single-cone-beam-computed-tomography-scan-to-obtain-full-occlusal-details-with-the-mandible-in-centric-relation-and-maximum-intercuspation
#11
Amr Ragab El-Beialy, Ayman El Nigoumi, Amgad Kaddah, Hisham Afify
INTRODUCTION: One obstacle with the implementation of digital technology in orthodontics is the acquisition of occlusal details while maintaining the mandible in the full interdigitation position. With 1 cone-beam computed tomography (CBCT) scan of the patient and 1 digital scan of the patient's dental models in occlusion, it might be possible to obtain full occlusal details and generate 2 volumes, with the mandible in centric relation and maximum intercuspation positions. The purpose of this article was to describe the technique...
May 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29691712/gc-formula-see-text-nmf-a-novel-matrix-factorization-framework-for-gene-phenotype-association-prediction
#12
Yaogong Zhang, Jiahui Liu, Xiaohu Liu, Yuxiang Hong, Xin Fan, Yalou Huang, Yuan Wang, Maoqiang Xie
Gene-phenotype association prediction can be applied to reveal the inherited basis of human diseases and facilitate drug development. Gene-phenotype associations are related to complex biological processes and influenced by various factors, such as relationship between phenotypes and that among genes. While due to sparseness of curated gene-phenotype associations and lack of integrated analysis of the joint effect of multiple factors, existing applications are limited to prediction accuracy and potential gene-phenotype association detection...
April 24, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29677964/improving-hospital-services-based-on-patient-experience-data-current-feedback-practices-and-future-opportunities
#13
Johanna Kaipio, Hanna Stenhammar, Susanna Immonen, Lauri Litovuo, Minja Axelsson, Minna Lantto, Pekka Lahdenne
Patient feedback is considered important for healthcare organizations. However, measurement and analysis of patient reported data is useful only if gathered insights are transformed into actions. This article focuses on gathering and utilization of patient experience data at hospitals with the aim of supporting the development of patient-centered services. The study was designed to explore both current practices of collecting and utilizing patient feedback at hospitals as well as future feedback-related opportunities...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29674008/applying-systems-ergonomics-methods-in-sport-a-systematic-review
#14
Adam Hulme, Jason Thompson, Katherine L Plant, Gemma J M Read, Scott Mclean, Amanda Clacy, Paul M Salmon
INTRODUCTION: As sports systems become increasingly more complex, competitive, and technology-centric, there is a greater need for systems ergonomics methods to consider the performance, health, and safety of athletes in context with the wider settings in which they operate. Therefore, the purpose of this systematic review was to identify and critically evaluate studies which have applied a systems ergonomics research approach in the context of sports performance and injury management...
April 16, 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29672929/functional-anatomy-of-the-hair-follicle-the-secondary-hair-germ
#15
REVIEW
Andrey A Panteleyev
The secondary hair germ (SHG) - a transitory structure in the lower portion of the mouse telogen hair follicle (HF) - is directly involved in anagen induction and eventual HF regrowth. Some crucial aspects of SHG functioning and ontogenetic relations with other HF parts, however, remain undefined. According to recent evidence (in contrast to previous bulge-centric views), the SHG is the primary target of anagen-inducing signaling and a source of both the outer root sheath (ORS) and ascending HF layers during the initial (morphogenetic) anagen sub-phase...
April 19, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29669861/informational-limits-of-biological-organisms
#16
Jussi Taipale
No abstract text is available yet for this article.
April 18, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29669705/diabetes-related-behavior-change-knowledge-transfer-to-primary-care-practitioners-and-patients-implementation-and-evaluation-of-a-digital-health-platform
#17
Samina Abidi, Michael Vallis, Helena Piccinini-Vallis, Syed Ali Imran, Syed Sibte Raza Abidi
BACKGROUND: Behavioral science is now being integrated into diabetes self-management interventions. However, the challenge that presents itself is how to translate these knowledge resources during care so that primary care practitioners can use them to offer evidence-informed behavior change support and diabetes management recommendations to patients with diabetes. OBJECTIVE: The aim of this study was to develop and evaluate a computerized decision support platform called "Diabetes Web-Centric Information and Support Environment" (DWISE) that assists primary care practitioners in applying standardized behavior change strategies and clinical practice guidelines-based recommendations to an individual patient and empower the patient with the skills and knowledge required to self-manage their diabetes through planned, personalized, and pervasive behavior change strategies...
April 18, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29659834/an-open-source-integrated-pedigree-data-management-and-visualization-tool-for-genetic-epidemiology
#18
Thilina Ranaweera, Enes Makalic, John L Hopper, Adrian Bickerstaffe
With advances in genetic epidemiology, increasingly large amounts of pedigree-related information are being collected by family studies, including twin studies. To date, biomedical data management systems that cater for family data have usually done so as part of their standard (non-family-centric) data model. Consequently, data managers with computing expertise are needed to extract family datasets and perform family-centric operations. We present a robust approach to handling large family datasets. Our approach is implemented as a new module which extends the capabilities of The Ark, an open-source web-based biomedical data management tool...
April 5, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29656859/dual-molecular-effects-of-dominant-rora-mutations-cause-two-variants-of-syndromic-intellectual-disability-with-either-autism-or-cerebellar-ataxia
#19
Claire Guissart, Xenia Latypova, Paul Rollier, Tahir N Khan, Hannah Stamberger, Kirsty McWalter, Megan T Cho, Susanne Kjaergaard, Sarah Weckhuysen, Gaetan Lesca, Thomas Besnard, Katrin Õunap, Lynn Schema, Andreas G Chiocchetti, Marie McDonald, Julitta de Bellescize, Marie Vincent, Hilde Van Esch, Shannon Sattler, Irman Forghani, Isabelle Thiffault, Christine M Freitag, Deborah Sara Barbouth, Maxime Cadieux-Dion, Rebecca Willaert, Maria J Guillen Sacoto, Nicole P Safina, Christèle Dubourg, Lauren Grote, Wilfrid Carré, Carol Saunders, Sander Pajusalu, Emily Farrow, Anne Boland, Danielle Hays Karlowicz, Jean-François Deleuze, Monica H Wojcik, Rena Pressman, Bertrand Isidor, Annick Vogels, Wim Van Paesschen, Lihadh Al-Gazali, Aisha Mohamed Al Shamsi, Mireille Claustres, Aurora Pujol, Stephan J Sanders, François Rivier, Nicolas Leboucq, Benjamin Cogné, Souphatta Sasorith, Damien Sanlaville, Kyle Retterer, Sylvie Odent, Nicholas Katsanis, Stéphane Bézieau, Michel Koenig, Erica E Davis, Laurent Pasquier, Sébastien Küry
RORα, the RAR-related orphan nuclear receptor alpha, is essential for cerebellar development. The spontaneous mutant mouse staggerer, with an ataxic gait caused by neurodegeneration of cerebellar Purkinje cells, was discovered two decades ago to result from homozygous intragenic Rora deletions. However, RORA mutations were hitherto undocumented in humans. Through a multi-centric collaboration, we identified three copy-number variant deletions (two de novo and one dominantly inherited in three generations), one de novo disrupting duplication, and nine de novo point mutations (three truncating, one canonical splice site, and five missense mutations) involving RORA in 16 individuals from 13 families with variable neurodevelopmental delay and intellectual disability (ID)-associated autistic features, cerebellar ataxia, and epilepsy...
April 10, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29652214/staff-perceptions-of-symptoms-approaches-to-assessment-and-challenges-to-assessment-among-children-with-cancer
#20
Lauri A Linder, Sarah E Wawrzynski
Nurses are often the first to recognize and respond to children's symptoms. This descriptive, exploratory study characterized how pediatric oncology health care providers characterize and assess children's cancer-related symptoms. The study also explored challenges associated with symptom assessment and information perceived as helpful in planning interventions. The setting was a Children's Oncology Group-affiliated hospital in the Intermountain West of the United States. Twenty-two pediatric oncology health care providers (95% female; 68% nurses) participated in one of four focus group sessions...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
keyword
keyword
44913
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"