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https://www.readbyqxmd.com/read/28938746/women-s-career-priority-is-associated-with-attitudes-towards-family-planning-and-ethical-acceptance-of-reproductive-technologies
#1
Michael K Simoni, Lin Mu, Stephen C Collins
STUDY QUESTION: Do women who place high importance on career success have different perceptions of pregnancy planning, delayed reproduction, and the ethical acceptability of ART than women with less emphasis on their career? SUMMARY ANSWER: Career-focused women place more importance on pregnancy planning, have greater confidence in delayed childbearing, and are more ethically accepting of donor gamete ART than women who do not place as much importance on career success...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28932469/ethyl-2-amino-1-4-fluoro-phen-yl-5-oxo-4-5-di-hydro-1h-pyrrole-3-carboxyl-ate-crystal-structure-and-hirshfeld-surface-analysis
#2
U H Patel, Chintan Jotaniya, D A Shah, Bhavesh Socha
In the title mol-ecule, C12H13FN2O3, the central pyrrole ring makes a dihedral angle of 9.2 (3)° with the eth-oxy carbonyl moiety whereas the fluoro-phenyl ring is rotated by 67.6 (2)° from the pyrrole ring. Supra-molecular aggregation is due to off-centric π-π stacking inter-actions involving screw-related pairs of mol-ecules, which are further connected by N-H⋯O and C-H⋯O inter-actions, forming a sinusoidal pattern along the [001] direction on the bc plane. Three-dimensional Hirshfeld surface analysis and two-dimensional fingerprint plots confirm the contributions of these inter-actions...
September 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28914051/chromosome-centric-human-proteome-project-allies-with-developmental-biology-a-case-study-of-the-role-of-y-chromosome-genes-in-organ-development
#3
Anna Meyfour, Paria Pooyan, Sara Pahlavan, Mostafa Rezaei-Tavirani, Hamid Gourabi, Hossein Baharvand, Ghasem Hosseini Salekdeh
One of the main goals of Chromosome-Centric Human Proteome Project is to identify protein evidence for missing proteins (MPs). Here, we present a case study of the role of Y chromosome genes in organ development and how to overcome the challenges facing MPs identification by employing human pluripotent stem cell differentiation into cells of different organs yielding unprecedented biological insight into adult silenced proteins. Y chromosome is a male-specific sex chromosome which escapes meiotic recombination...
September 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28910996/think-adult-think-child-why-should-staff-caring-for-dying-adults-ask-what-the-death-means-for-children-in-the-family
#4
Sir Al Aynsley-Green
Introduction: Bereaved children and young people in the UK are 'hidden mourners'. Sources of data: Review of primary and secondary evidence on childhood bereavement. Area of agreement: Children experience grief that varies according to the circumstance of death and their cognitive ability. Voluntary organizations can be supportive, but provision is patchy and vulnerable to austerity. Areas of concern: Adult-centric denial of the importance and long-term consequences of childhood grief; uncertainty in how best to relate to bereaved children in faiths and in schools...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28910965/actinobacteria-phylogenomics-selective-isolation-from-an-iron-oligotrophic-environment-and-siderophore-functional-characterization-unveil-new-desferrioxamine-traits
#5
Pablo Cruz-Morales, Hilda E Ramos-Aboites, Cuauhtémoc Licona-Cassani, Nelly Selem-Mójica, Paulina M Mejía-Ponce, Valeria Souza-Saldívar, Francisco Barona-Gómez
Desferrioxamines are hydroxamate siderophores widely conserved in both aquatic and soil-dwelling Actinobacteria. While the genetic and enzymatic bases of siderophore biosynthesis and their transport in model families of this phylum are well understood, evolutionary studies are lacking. Here, we perform a comprehensive desferrioxamine-centric (des genes) phylogenomic analysis, which includes the genomes of six novel strains isolated from an iron and phosphorous depleted oasis in the Chihuahuan desert of Mexico...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28882809/the-user-knows-what-to-call-it-incorporating-patient-voice-through-user-contributed-tags-on-a-participatory-platform-about-health-management
#6
Annie T Chen, Rachel M Carriere, Samantha Jan Kaplan
BACKGROUND: Body listening, described as the act of paying attention to the body's signals and cues, can be an important component of long-term health management. OBJECTIVE: The aim of this study was to introduce and evaluate the Body Listening Project, an innovative effort to engage the public in the creation of a public resource-to leverage collective wisdom in the health domain. This project involved a website where people could contribute their experiences of and dialogue with others concerning body listening and self-management...
September 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28875732/pain-management-concerns-from-the-hospice-family-caregivers-perspective
#7
Nai-Ching Chi, George Demiris, Kenneth C Pike, Karla Washington, Debra Parker Oliver
BACKGROUND: Pain management is a challenging task for family caregivers in home hospice care. However, there are limited studies that examine the challenges regarding pain management in hospice care from family caregivers' perspectives. OBJECTIVES: To identify the challenges related to pain management faced by family caregivers in hospice care and to examine the validity of an existing framework that outlines pain management challenges for hospice family caregivers...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28859829/multi-model-based-interactive-authoring-environment-for-creating-shareable-medical-knowledge
#8
Taqdir Ali, Maqbool Hussain, Wajahat Ali Khan, Muhammad Afzal, Jamil Hussain, Rahman Ali, Waseem Hassan, Arif Jamshed, Byeong Ho Kang, Sungyoung Lee
OBJECTIVE: Technologically integrated healthcare environments can be realized if physicians are encouraged to use smart systems for the creation and sharing of knowledge used in clinical decision support systems (CDSS). While CDSSs are heading toward smart environments, they lack support for abstraction of technology-oriented knowledge from physicians. Therefore, abstraction in the form of a user-friendly and flexible authoring environment is required in order for physicians to create shareable and interoperable knowledge for CDSS workflows...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28839479/efficacy-of-selective-grinding-guided-by-an-occlusal-splint-in-management-of-myofascial-pain-a-prospective-clinical-trial
#9
REVIEW
Felipe J Fernández-González, Jorge Cabero-López, Aritza Brizuela, Ivan Suazo, Esteban Pérez-Pevida, Teresa Cobo, Oier Montalban, Markel Diéguez-Pereira, David Chávarri-Prado, Iker Bellanco de la Pinta, Antonio Jiménez-Garrudo
BACKGROUND: For patients whose centric relation (CR) has not been considered at the start and during treatment, the task of achieving an occlusal scheme that works together with the temporomandibular joint, the muscles, and the structures of the stomatognathic apparatus becomes a major concern. OBJECTIVE: This study aims to describe a reproducible, predictable and to date unreported procedure of selective grinding guided by an occlusal splint and to analyze condylar position (CP) based on the skeletal pattern...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28814837/simulating-clinical-trial-visits-yields-patient-insights-into-study-design-and-recruitment
#10
S Sam Lim, Alan J Kivitz, Doug McKinnell, M Edward Pierson, Faye S O'Brien
PURPOSE: We elicited patient experiences from clinical trial simulations to aid in future trial development and to improve patient recruitment and retention. PATIENTS AND METHODS: Two simulations of draft Phase II and Phase III anifrolumab studies for systemic lupus erythematosus (SLE)/lupus nephritis (LN) were performed involving African-American patients from Grady Hospital, an indigent care hospital in Atlanta, GA, USA, and white patients from Altoona Arthritis and Osteoporosis Center in Altoona, PA, USA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28814332/efficacy-and-safety-of-sarolaner-simparica-%C3%A2-in-the-treatment-and-control-of-naturally-occurring-flea-infestations-in-dogs-presented-as-veterinary-patients-in-australia
#11
REVIEW
Raj Packianathan, Sally Colgan, Andrew Hodge, Kylie Davis, Robert H Six, Steven Maeder
BACKGROUND: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica(®), Zoetis) and spinosad (Comfortis(®), Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. METHODS: A total of 162 client-owned dogs (80 in northern study and 82 in southern study) from 105 households were enrolled...
August 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28810956/the-reasons-for-living-scale-military-version-assessing-protective-factors-against-suicide-in-a-military-sample
#12
Anne-Marie Deutsch, R Gregory Lande
INTRODUCTION: Military suicide rates have been rising over the past decade and continue to challenge military treatment facilities. Assessing suicide risk and improving treatments are a large part of the mission for clinicians who work with uniformed service members. This study attempts to expand the toolkit of military suicide prevention by focusing on protective factors over risk factors. In 1983, Marsha Linehan published a checklist called the Reasons for Living Scale, which asked subjects to check the reasons they choose to continue living, rather than choosing suicide...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28805214/the-low-populated-folding-intermediate-of-a-mutant-of-the-fyn-sh3-domain-identified-by-a-simple-model
#13
Jing Wu, Guojun Chen, Zhuqing Zhang, Ping Zhang, Tao Chen
Experimental studies indicate that the A39V/N53P/V55L Fyn SH3 domain folds from the unfolded state to the native state via a low-populated on-pathway intermediate, whereas the folding of the wildtype is two-state-like. To get insights into the biophysical basis of their different folding mechanisms, we used native-centric models with and without additional transferrable, sequence-dependent nonnative hydrophobic interactions to study the folding behaviors of the Fyn SH3 domain and its mutant. The pure native-centric model predicts that both the wildtype and the mutant fold in a two-state manner, without any detectable intermediate...
August 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28789788/alexithymia-and-anesthetic-bladder-capacity-in-interstitial-cystitis-bladder-pain-syndrome
#14
Chui-De Chiu, Ming-Huei Lee, Wei-Chih Chen, Hoi Lam Ho, Huei-Ching Wu
OBJECTIVE: In contrast to the inconsistent results of organic causes, it has been found that psychological risk factors are reliably related to functional somatic syndromes (FSSs), including interstitial cystitis/bladder pain syndrome (IC/BPS). Compared to patients with acute cystitis, a subgroup of IC/BPS patients with a history of childhood relational trauma reported intensified unregulated affective states (i.e., anxiety and depression) and trauma-related psychopathology (i.e., dissociation)...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28762650/ancient-and-modern-hints-of-a-core-post-transcriptional-network-driving-chemotherapy-resistance-in-ovarian-cancer
#15
REVIEW
Sarah Blagden, Mai Abdel Mouti, James Chettle
RNA-binding proteins (RBPs) and noncoding (nc)RNAs (such as microRNAs, long ncRNAs, and others) cooperate within a post-transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP-centric approach, we explore the current knowledge surrounding contributers to post-transcriptional gene regulation (PTGR) in ovarian cancer and identify commonalities that hint at the existence of an evolutionarily conserved core PTGR network...
August 1, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/28762279/family-factors-in-adolescent-problematic-internet-gaming-a-systematic-review
#16
Luke A Schneider, Daniel L King, Paul H Delfabbro
Background and aims Familial influences are known to affect the likelihood of an adolescent becoming a problem gamer. This systematic review examined some of the key findings in empirical research on family factors related to adolescent problem gaming. Methods A total of 14 studies in the past decade were evaluated. Family-related variables included: (a) parent status (e.g., socioeconomic status and mental health), (b) parent-child relationship (e.g., warmth, conflict, and abuse), (c) parental influence on gaming (e...
August 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28754675/connecting-cancer-to-its-causes-requires-incorporation-of-effects-on-tissue-microenvironments
#17
James DeGregori
In a recent paper in Science, Tomasetti et al. present an expanded model for cancer risk, which they claim demonstrates the relative contribution of mutations caused by replication errors, environment and heredity. The foundation of this model is the theory that the overwhelming driver of cancer risk is mutations. This perspective will present experimental evidence and evolutionary theory to challenge the basis of this underlying theory. An argument will be presented that the mutation-centric model of cancer suggests unrealistic solutions to cancer and distracts the research community from more promising approaches that consider tissue context...
July 28, 2017: Cancer Research
https://www.readbyqxmd.com/read/28740266/reproducibility-of-centric-relation-techniques-by-means-of-condyle-position-analysis
#18
Nikolina Holen Galeković, Vesna Fugošić, Vedrana Braut, Robert Ćelić
PURPOSE: The aim of this study was to determine the reproducibility of clinical centric relation (CR) registration techniques (bimanual manipulation, chin point guidance and Roth's method) by means of condyle position analysis. MATERIAL AND METHODS: Thirty two fully dentate asymptomatic subjects (16 female and 16 male) with normal occlusal relations (Angle class I) participated in the study (mean age, 22.6 ± 4.7 years). The mandibular position indicator (MPI) was used to analyze the three-dimensional (anteroposterior (ΔX), superoinferior (ΔZ), mediolateral (ΔY)) condylar shift generated by the difference between the centric relation position (CR) and the maximal intercuspation position (MI) observed in dental arches...
March 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28719615/a-human-tissue-based-functional-assay-platform-to-evaluate-the-immune-function-impact-of-small-molecule-inhibitors-that-target-the-immune-system
#19
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune system to ameliorate disease also carry a risk of immunosuppression that could lead to adverse outcomes. Therefore, it is important to understand the 'immune fingerprint' of novel therapeutics as they relate to current and, clinically used immunological therapies to better understand their potential therapeutic benefit as well as immunosuppressive ability that might lead to adverse events such as infection risks and cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28713763/evaluation-of-three-different-processing-techniques-in-the-fabrication-of-complete-dentures
#20
Vamsi Krishna Chintalacheruvu, Rajasekaran Uttukuli Balraj, Lavanya Sireesha Putchala, Sreelekha Pachalla
AIMS AND OBJECTIVES: The objective of the present study is to compare the effectiveness of three different processing techniques and to find out the accuracy of processing techniques through number of occlusal interferences and increase in vertical dimension after denture processing. MATERIALS AND METHODS: A cross-sectional study was conducted on a sample of 18 patients indicated for complete denture fabrication was selected for the study and they were divided into three subgroups...
June 2017: Journal of International Society of Preventive & Community Dentistry
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