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https://www.readbyqxmd.com/read/28334780/eif4a3-deficient-human-ipscs-and-mouse-models-demonstrate-neural-crest-defects-that-underlie-richieri-costa-pereira-syndrome
#1
Emily E Miller, Gerson S Kobayashi, Camila M Musso, Miranda Allen, Felipe A A Ishiy, Luiz C de Caires Junior, Ernesto S G Guimarães, Karina Griesi-Oliveira, Roseli M Zechi-Ceide, Antonio Richieri-Costa, Debora R Bertola, Maria Rita Passos-Bueno, Debra L Silver
Biallelic loss-of-function mutations in the RNA binding protein EIF4A3 cause Richieri-Costa-Pereira syndrome (RCPS), an autosomal recessive condition mainly characterized by craniofacial and limb malformations. However, the pathogenic cellular mechanisms responsible for this syndrome are entirely unknown. Here we used two complementary approaches, patient-derived induced pluripotent stem cells (iPSCs) and conditional Eif4a3 mouse models, to demonstrate that defective Neural Crest Cell (NCC) development explains RCPS craniofacial abnormalities...
March 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28330575/clinical-management-of-the-homozygous-%C3%AE-thalassemia-with-unusual-mandibular-manifestation-of-hematopoiesis
#2
J A Ruiz-Roca, R E Oñate-Sánchez, I Urrutia-Rodríguez, A Martínez-Izquierdo, D Mengual-Pujante, F J Rodríguez-Lozano
Alpha (α)-thalassemias are the most common genetic disorder of hemoglobin (Hb) synthesis, affecting up to 5% of the world's population. These congenital hemolytic anemias induce extramedullary hematopoiesis, including the liver, spleen, sinuses, and the diploic spaces of the skull. Oral health problems in patients with thalassemias are mostly related to a varied degree of facial deformities, malocclusions, and/or dental arch dimensions. We present a case with a 49-year-old man, diagnosed with homozygous α thalassemia that came to the Faculty of Dentistry at the University of Murcia for a dental treatment...
February 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28328598/simple-percutaneous-transbuccal-approach-for-management-of-mandibular-angular-fracture
#3
Mohammad Waheed El-Anwar, Ahmed Hassan Sweed
OBJECTIVE: To describe a relatively simple, easy, and safe technique for open reduction and internal fixation of the mandibular angle fracture using the combined modified percutaneous and oral approach with no special instrumentation. PATIENTS AND METHODS: This study was carried out on 10 patients who had traumatic mandibular angle fractures. All patients were managed by open reduction and internal fixation. Intraoral exposure and reduction of the fracture was performed through the gingivolabial incision...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28327698/accuracy-and-reliability-of-different-cone-beam-computed-tomography-cbct-devices-for-structural-analysis-of-alveolar-bone-in-comparison-with-multislice-ct-and-micro-ct
#4
Jeroen Van Dessel, Laura Ferreira Pinheiro Nicolielo, Yan Huang, Walter Coudyzer, Benjamin Salmon, Ivo Lambrichts, Reinhilde Jacobs
OBJECTIVE: The aim of this study was to assess whether cone beam computed tomography (CBCT) may be used for clinically reliable alveolar bone quality assessment in comparison to its clinical alternatives, multislice computed tomography and the gold standard (micro-CT). MATERIALS AND METHODS: Six dentate mandibular bone samples were scanned with seven CBCT devices (ProMax 3D Max, NewTom GiANO, Cranex 3D, 3D Accuitomo 170, Carestream 9300, Scanora 3D, I-CAT Next generation), one micro-CT scanner (SkyScan 1174) and one MSCT machine (Somatom Definition Flash) using two protocols (standard and high-resolution)...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28326710/-finite-elemental-analysis-of-the-influence-of-mandibular-plane-angle-on-the-stress-distribution-of-implant-tooth
#5
Xing Weibin, Zheng Shuxian, Yang Shiyi
OBJECTIVE: Finite elemental analysis of the mechanical characteristics of a first mandibular implant molar under different mandibular plane angles determines the load conditions on the implant, thereby providing guidance for clinical application. METHODS: CT data of three mandibular plane angles (low, average, high) were collected. A finite elemental combination model of a dental implant was constructed. The orthogonal experimental research was designed. Results followed data collection and analysis...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326709/-cone-beam-computed-tomography-analysis-of-the-bony-structure-of-the-temporomandibular-joint-during-two-phase-treatment-with-herbst-appliance
#6
Chen Weiwei, Sang Ting, Huang Zhen, Wu Jun
OBJECTIVE: This study assessed the effects of two-phase treatment with Herbst appliance on the bony structure of the temporomandibular joint via cone beam computed tomography (CBCT) analysis. METHODS: This study selected 15 patients exhibiting early permanent dentition and classⅡmalocclusion combined with mandibular retrusion treated by a two phase treatment (Herbst and fixed appliance). The CBCT scans of the patients were obtained at the following stages: 2 weeks before Herbst treatment (T1), at the start of treatment when the Herbst appliance was set in place (T2), immediately after removal of the Herbst appliance (T3), and immediately after removal of the edgewise appliance (T4)...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326704/-extramedullary-fixation-combined-with-intramedullary-fixation-in-the-surgical-reduction-of-sagittal-mandibular-condylar-fractures
#7
Chen Chuanjun, Chen Xiaoyang, Chen Jing
OBJECTIVE: This study aimed to evaluate the clinical effect of extramedullary fixation combined with intramedullary fixation during the surgical reduction of sagittal mandibular condylar fractures. METHODS: Twenty-four sagittal fractures of the mandibular condyle in18 patients were fixed by two appliances: intramedullary with one long-screw osteosynthesis or Kirschner wire and extramedullary with one micro-plate. The radiologically-recorded post-operative stability-associated com-plications included the screw/micro-plate loosening, micro-plate twisting, micro-plate fractures, and fragment rotation...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28322450/patient-compliance-following-isolated-mandibular-fracture-repair
#8
J Paul Radabaugh, Adam Van Horn, Stephen A Chan, Jared M Shelton, Thomas J Gal
OBJECTIVE: Compliance with postoperative care in the maxillofacial trauma population often is considered poor. This lack of follow-up does not seem to be a function of decreased access to care but rather its anticipated lack of utilization. The goal of this study is to identify what factors are associated with increased compliance in postoperative management of mandible fractures. STUDY DESIGN: Retrospective cohort study. METHODS: Using Current Procedural Terminology codes to identify maxillofacial injuries requiring operative repair, a subset of isolated mandibular fractures was identified...
March 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28317556/skull-5-from-dmanisi-descriptive-anatomy-comparative-studies-and-evolutionary-significance
#9
G Philip Rightmire, Marcia S Ponce de León, David Lordkipanidze, Ann Margvelashvili, Christoph P E Zollikofer
A fifth hominin skull (cranium D4500 and mandible D2600) from Dmanisi is massively constructed, with a large face and a very small brain. Traits documented for the first time in a basal member of the Homo clade include the uniquely low ratio of endocranial volume to basicranial width, reduced vertex height, angular vault profile, smooth nasal sill coupled with a long and sloping maxillary clivus, elongated palate, and tall mandibular corpus. The convex clivus and receding symphysis of skull 5 produce a muzzle-like form similar to that of Australopithecus afarensis...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28317283/radiological-and-microsurgical-anatomy-for-variation-of-the-mandible-comparative-study-of-human-and-macaca-fascicularis
#10
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Yoko Tabira, Eishi Hirasaki, Christian Fisahn, R Shane Tubbs, Jingo Kusukawa, Koh-Ichi Yamaki
Recent studies using cone-beam computer tomography (CBCT) have added to our understanding of anatomical variation in the mandible of humans. However, the distribution of nerves cannot be revealed by CBCT. There have been investigations of the distribution of nerves relating to the mandible, but some proposed causes of these variations remain controversial. In this study, we observed a total of 10 sides from five mandibles of Macaca fascicularis of unknown age and sex using CBCT and dissection under stereomicroscopy...
March 20, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28317243/implant-supported-mandibular-removable-partial-dentures-functional-clinical-and-radiographical-parameters-in-relation-to-implant-position
#11
Charlotte Jensen, Caroline M Speksnijder, Gerry M Raghoebar, Wouter Kerdijk, Henny J A Meijer, Marco S Cune
BACKGROUND: Patients with a Kennedy class I situation often encounter problems with their removable partial denture (RPD). PURPOSE: To assess the functional benefits of implant support to RPDs, the clinical performance of the implants and teeth and to determine the most favorable implant position: the premolar (PM) or molar (M) region. MATERIALS AND METHODS: Thirty subjects received 2 PM and 2 M implants. A new RPD was made. Implant support was provided 3 months later...
March 20, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28316914/morphometric-analysis-of-prognathic-and-non-prognathic-mandibles-in-relation-to-bsso-sites-using-cbct
#12
Tengku Aszraf Tengku Shaeran, Ramizu Shaari, Shafulizan Abdul Rahman, Mohammad Khursheed Alam, Alauddin Muhamad Husin
BACKGROUND: Bilateral sagittal split osteotomy (BSSO) is the most versatile procedure and adopted by many surgeons to relocate the mandible in patients having mandibular prognathism (MP). Injury to the inferior alveolar nerve (IAN) and unfavorable splits are two surgical complications of BSSO which are associated with mandibular morphology. Uses of cone beam computed tomography (CBCT) in providing 3-D images has gained a wider acceptance in surgical field nowadays. Its advantages are including reduced cost, lesser radiation dose and smaller physical footprint comparing to the conventional computed tomography...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28314422/maxillofacial-and-mandibular-fractures-in-sports
#13
REVIEW
Christopher F Viozzi
Sports account for 3% to 29% of facial injuries and 10% to 42% of facial fractures. Fractures of the facial skeleton most commonly occur owing to interpersonal violence or motor vehicle crashes. Facial fractures from sporting activities has clearly decreased over time owing to better preventive measures. However, this decreasing trend is offset by the emergence of more dangerous sports activities, or "pushing the envelope" of traditional sports activities. Fractures can occur from contact between athletes, and between athletes and their surroundings...
April 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28314082/an-international-survey-among-prosthodontists-of-the-use-of-mandibular-implant-supported-dental-prostheses
#14
Mats Kronstrom, Gunnar E Carlsson
PURPOSE: To evaluate the use of implant-supported overdentures (IOD) and implant-supported fixed dental prostheses (IFDP) in patients with edentulous mandibles among international prosthodontists. MATERIALS AND METHODS: A questionnaire was sent by e-mail to all clinically active prosthodontists in the International College of Prosthodontists with questions related to implant treatment of the edentulous mandible performed in 2015. RESULTS: One hundred and sixteen prosthodontists from 33 countries responded to the questionnaire...
March 17, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28306134/further-evidence-of-a-prolonged-hypotensive-and-a-bradycardic-effect-after-mandibular-extension-in-normal-volunteers
#15
C Del Seppia, S Ghione, Paola Foresi, E Fommei, D Lapi, A Colantuoni, R Scuri
We previously reported that in normotensive humans submaximal mouth opening (mandibular extension) obtained by an ad hoc dilator (spring device), associated with partial masticatory movements and prolonged for 10 minutes is followed by a long-lasting reduction of blood pressure (BP) and heart rate (HR). Similar results were obtained by us in anesthetized rats. A recent independent study failed to confirm the results in the normotensive human. We reassessed, in 25 normotensive volunteers, the effects on BP and HR of mandibular extension obtained by the spring device associated with partial masticatory movements compared to a control procedure, consisting in keeping a tongue depressor between the incisor teeth...
December 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28302228/anaesthetic-management-in-a-child-with-goldenhar-syndrome
#16
Waqas Ahmed Khan, Bushra Salim, Ausaf Ahmed Khan, Shakaib Chughtai
Goldenhar syndrome is a congenital disorder involving deformities of the face. It usually affects one side of the face only and poses significant challenges in the airway management. We herein, report an 8-year boy, known case of Goldenhar syndrome, who presented to our radiology suite for a magnetic resonance imaging (MRI) brain, followed by a computed tomography (CT) scan brain. The boy had various features of Goldenhar syndrome, e.g. cleft palate, absent right eye and ear, right mandibular hypoplasia, micrognathia, and preauricular tags...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28300494/three-dimensional-morphological-characterization-of-malocclusions-with-mandibular-lateral-displacement-using-cone-beam-computed-tomography
#17
Roberto L Velásquez, Jorge C Coro, Alejandra Londoño, Susan P McGorray, Timothy T Wheeler, Sadao Sato
OBJECTIVE: The purpose of this study was to evaluate the morphologic characteristics of MLD malocclusions using 3D imaging. MATERIALS AND METHODS: MLD characteristics were examined using CBCT data in 40 subjects. A 3D Cephalometric analysis was developed to describe the spatial position of the mandible and temporal bones. RESULTS: Vertical dental heights were shorter and the posterior occlusal plane (POP) presented a steeper sagittal inclination on the shifted side (the side of the laterally displaced bony chin) than on the contralateral side...
March 16, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28296166/bony-pits-in-the-ostrich-struthio-camelus-and-emu-dromaius-novaehollandiae-bill-tip
#18
Martina R Crole, John T Soley
A specialized region of the bill tip characterized by a complex arrangement of mechanoreceptors and referred to as a bill tip organ, has been identified in numerous avians. A bill tip organ was initially inferred in kiwi species by the presence of numerous, bony pits in the rostrum of the bill, and later confirmed histologically. This study enumerates and compares the number and distribution of pits present in the bill tip in the ostrich and emu. The heads from 10 ostrich and 5 emu were prepared for osteological examination...
March 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28294380/oral-appliance-therapy-versus-nasal-continuous-positive-airway-pressure-in-obstructive-sleep-apnea-syndrome-a-randomized-placebo-controlled-trial-on-self-reported-symptoms-of-common-sleep-disorders-and-sleep-related-problems
#19
Maria Nikolopoulou, Anna Byraki, Jari Ahlberg, Martijn W Heymans, H L Hamburger, Jan De Lange, Frank Lobbezoo, Ghizlane Aarab
Obstructive sleep apnea syndrome (OSAS) is associated with several sleep disorders and sleep-related problems. Therefore, the aim of this study was to compare the effects of a mandibular advancement device (MAD) with those of nasal continuous positive airway pressure (nCPAP) on self-reported symptoms of common sleep disorders and sleep-related problems in mild and moderate OSAS patients. In this randomized placebo-controlled trial sixty-four OSAS patients (52.0± 9.6 years) were randomly assigned to an MAD, nCPAP or an intra-oral placebo appliance in a parallel design...
March 10, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28292598/clinical-and-radiographic-characteristics-of-vertical-root-fractures-in-endodontically-and-nonendodontically-treated-teeth
#20
Wan-Chuen Liao, Yi-Ling Tsai, Chen-Ying Wang, Mei-Chi Chang, Wei-Ling Huang, Hsueh-Jen Lin, Hsin-Cheng Liu, Chiu-Po Chan, Shu-Hui Chang, Jiiang-Huei Jeng
INTRODUCTION: A vertical root fracture (VRF) is a root fracture extending along the longitudinal axis of roots and is often noted in endodontically treated teeth. However, the clinical and radiographic characteristics of VRFs are not completely known. METHODS: A total of 65 teeth with 68 vertical fractured roots in 58 Chinese patients were investigated. The clinical examination records and radiographic images were reviewed in detail. RESULTS: A total of 24 male (41...
March 11, 2017: Journal of Endodontics
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