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https://www.readbyqxmd.com/read/28728827/the-use-of-perioperative-ketorolac-in-the-surgical-treatment-of-pediatric-spontaneous-pneumothorax
#1
R Michael Dorman, George Ventro, Sarah B Cairo, Kaveh Vali, David H Rothstein
BACKGROUND: We sought to determine the effect of ketorolac on pediatric primary spontaneous pneumothorax recurrence after operation. METHODS: The Pediatric Health Information System database was queried for patients ages 10-16years discharged in the years 2004-2014 with pneumothorax or pleural bleb and a related operative procedure. Deaths and secondary pneumothorax were excluded. Variables included demographics, chronic disease, intensive care unit admission, mechanical ventilation, and lung resection or plication...
June 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28688509/preoperative-prednisolone-and-ketorolac-may-result-in-a-small-reduction-of-postoperative-endodontic-pain-compared-with-placebo
#2
Romina Brignardello-Petersen
No abstract text is available yet for this article.
June 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28668243/effect-of-misoprostol-on-patients-with-aspirin-exacerbated-respiratory-disease-undergoing-aspirin-challenge-and-desensitization
#3
Kristen M Walters, Ronald A Simon, Katharine M Woessner, Nathan E Wineinger, Andrew A White
BACKGROUND: Prostaglandin E2 (PGE2) is an anti-inflammatory compound that inhibits 5-lipoxygenase activity. Diminished PGE2 regulation in aspirin-exacerbated respiratory disease (AERD) leads to respiratory reactions on cyclooxygenase 1 inhibition. In vitro studies have found that exogenous PGE2 stabilizes inflammatory mediator release. OBJECTIVE: To examine whether misoprostol (oral prostaglandin E1 analogue) use during aspirin challenge and desensitization might decrease the severity of aspirin-induced symptoms and make desensitization safer for patients with AERD...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28663395/a-pragmatic-randomised-controlled-trial-comparing-the-efficacy-of-a-femoral-nerve-block-and-periarticular-infiltration-for-early-pain-relief-following-total-knee-arthroplasty
#4
P D H Wall, N R Parsons, H Parsons, J Achten, S Balasubramanian, P Thompson, M L Costa
AIMS: The aim of this study was to compare the effectiveness of a femoral nerve block and a periarticular infiltration in the management of early post-operative pain after total knee arthroplasty (TKA). PATIENTS AND METHODS: A pragmatic, single centre, two arm parallel group, patient blinded, randomised controlled trial was undertaken. All patients due for TKA were eligible. Exclusion criteria included contraindications to the medications involved in the study and patients with a neurological abnormality of the lower limb...
July 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28653583/warm-and-humidified-versus-cold-and-dry-co2-pneumoperitoneum-in-minimally-invasive-colon-resection-a-randomized-controlled-trial
#5
Elie Sutton, Geoffrey Bellini, Michael J Grieco, H M C Shantha Kumara, Xiaohong Yan, Vesna Cekic, Linda Njoh, Richard L Whelan
INTRODUCTION: Peritoneal insufflation with warm-humidified (WH) CO2 gas during minimally invasive surgical procedures is purported to prevent hypothermia and peritoneal desiccation and is associated with decreased postoperative IL-6 levels. This randomized study's purpose was to determine the clinical impact of WH versus cold-dry (CD) CO2 in minimally invasive colon resection (MICR), and to assess perioperative plasma levels of IL-6, TIMP-1, sVEGF-R1, and HSP-70 after MICR. METHODS: Operative and short-term clinical data plus perioperative blood samples were collected on MICR patients randomized to receive either WH (36...
June 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28651711/betamethasone-does-not-seem-to-provide-benefits-in-postoperative-pain%C3%A2-and-swelling-when-added-to-ketorolac-after-placement-of-multiple-implants
#6
Romina Brignardello-Petersen
No abstract text is available yet for this article.
July 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28641495/mixing-local-anaesthetics-corticosteroid-and-ketorolac-tromethamine-leads-to-no-extreme-ph-or-precipitation
#7
M Q H Leow, K S Chua, S C Tay
No abstract text is available yet for this article.
June 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28625001/nanostructured-sba-15-host-applied-in-ketorolac-tromethamine-release-system
#8
Jorgelina Cussa, Juliana M Juárez, Marcos B Gómez Costa, Oscar A Anunziata
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28615924/comparison-of-the-frequency-of-use-of-a-pupil-expansion-device-with-and-without-an-intracameral-phenylephrine-and-ketorolac-injection-1-0-3-at-the-time-of-routine-cataract-surgery
#9
Frank A Bucci, Breanne Michalek, Angel T Fluet
PURPOSE: The objective of this study is to evaluate whether a phenylephrine and ketorolac injection 1%/0.3% (phenyl/keto injection) (Omidria(®)) prior to capsulotomy decreases the need for the Malyugin Ring(®) to manage small pupils. SETTING: Bucci Laser Vision Institute, Wilkes-Barre, PA, USA. DESIGN: Retrospective analysis of cataract surgeries performed by a single surgeon at a single center. METHODS: A historical control group of 1,004 consecutive cases (December 2013 to February 2015) did not receive a phenyl/keto intracameral injection prior to capsulotomy and were compared with 915 consecutive cases in the treatment group (June 2015 to April 2016) for the rate of use of the Malyugin Ring...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28609318/biochemical-and-pharmacological-characterization-of-a-mice-model-of-complex-regional-pain-syndrome
#10
Vaskar Das, Jeffrey S Kroin, Mario Moric, Asokumar Buvanendran
BACKGROUND AND OBJECTIVES: Complex regional pain syndrome is a challenging disease to treat. Recently, a mouse fracture model of complex regional pain syndrome has been developed that has many signs of the clinical syndrome. However, many aspects of the sensory neuron biochemistry and behavioral and pharmacological characterization of this model remain to be clarified. METHODS: Mice were randomly assigned to fracture/cast or control (naive) groups. Fracture/cast mice underwent a closed distal tibia facture, with hindlimb wrapped in casting tape for 3 weeks...
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28602319/intracameral-ketorolac-and-phenylephrine-effect-on-intraoperative-pupil-diameter-and%C3%A2-postoperative-pain-in-cataract-surgery
#11
Eric D Donnenfeld, J Steven Whitaker, Mitchell A Jackson, John Wittpenn
PURPOSE: To evaluate the study drug OMS302 (Omidria [phenylephrine and ketorolac injection 1.0%/0.3%]) compared with a balanced salt solution (vehicle), ketorolac, and phenylephrine on pupil diameter during cataract surgery and early postoperative ocular pain. SETTING: Twenty-three centers in the United States. DESIGN: Randomized clinical trial. METHODS: Patients were randomized (1:1:1:1) to receive vehicle, phenylephrine, ketorolac, or the study drug containing phenylephrine and ketorolac administered intracamerally during surgery...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28600856/in-vitro-anti-lps-dose-determination-of-ketorolac-tromethamine-and-in-vivo-safety-of-repeated-dosing-in-healthy-horses
#12
A W Bianco, G E Moore, B R Cooper, S D Taylor
Flunixin meglumine (FM) is a commonly used Nonsteroidal anti-inflammatory drug (NSAID) in horses, but clinical efficacy is often unsatisfactory. Ketorolac tromethamine (KT) demonstrates superior efficacy compared to other NSAIDs in humans, but its anti-inflammatory effects have not been investigated in the horse. Safety of repeated dosing of KT has not been evaluated. The first objective was to conduct a dose determination study to verify that a previously described dosage of KT would inhibit Lipopolysaccharide (LPS)-induced eicosanoid production in vitro, and to compare KT effects of this inhibition to those of FM...
June 10, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28592157/correlation-between-nasal-epithelial-injury-and-in-vitro-cytotoxicity-using-a-series-of-small-molecule-protein-tyrosine-phosphatase-1b-inhibitors-investigated-for-reversal-of-leptin-resistance-in-obesity
#13
Alan P Brown, Chandrassegar Saravanan, Patrick Devine, Maria Magnifico, Jiaping Gao, Valerie Beaulieu, Fupeng Ma, Kayo Yasoshima, David Barnes-Seeman, Ken Yamada
This research provides a cautionary example when evaluating changes in behavioral end points with respect to postulated pharmacologic activity. Various small molecule substrate mimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors were investigated as pharmacologic agents for decreasing food consumption using intranasal (IN) dosing as a means for direct nose-to-brain delivery along the olfactory/trigeminal nerve pathways. Although food consumption was decreased in diet-induced obese (DIO) mice, nasal discharge was observed...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28591085/influence-of-oprm1-polymorphism-on-post-operative-pain-after-intrathecal-morphine-administration-in-italian-patients-undergoing-elective-cesarean-section
#14
Eleonora Pettini, Massimo Micaglio, Ubaldo Bitossi, Angelo Raffaele De Gaudio, Duccio Rossi Degl'Innocenti, Lorenzo Tofani, Vittorio Limatola, Chiara Adembri, Alessandro Di Filippo
OBJECTIVES: the aim of this prospective observational study was to evaluate the influence of OPRM1 polymorphism on the analgesic efficacy (including VAS scores and requirement for rescue analgesia) of a standard dose of intrathecal morphine METHODS:: an Italian cohort of 63 parturients, scheduled for elective cesarean section at a tertiary University Hospital, received a spinal anesthesia with hyperbaric bupivacaine and morphine 100 mcg. For the first 48 hours in the post-operative period the patients received acetaminophen 1 g IV q6hr...
June 6, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28590059/sympatholytic-effect-of-intravascular-atp-is-independent-of-nitric-oxide-prostaglandins-na-k-atpase-and-kir-channels-in-humans
#15
Christopher M Hearon, Jennifer C Richards, Mathew L Racine, Gary J Luckasen, Dennis G Larson, Michael J Joyner, Frank A Dinenno
Exercise and intravascular ATP elicit vasodilatation that is dependent on activation of inwardly rectifying potassium (KIR ) channels, with a modest reliance on nitric oxide (NO) and prostaglandin (PG) synthesis.  Both exercise and intravascular ATP attenuate sympathetic α-adrenergic vasoconstriction (sympatholysis). However, KIR channels, NO, PGs and Na(+) /K(+) -ATPase activity are not obligatory to observe sympatholysis during exercise. To further determine similarities between exercise and intravascular ATP, we tested the hypothesis that inhibition of KIR channels, NO and PG synthesis, and Na(+) /K(+) -ATPase, would not alter the ability of ATP to blunt α1 -adrenergic vasoconstriction...
June 7, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28574391/non-steroidal-anti-inflammatory-drugs-s-antinociception-mediated-by-the-opioid-mechanism-in-the-nucleus-raphe-magnus
#16
T Gorgiladze, I Nozadze, E Abzianidze, M Tsagareli
It has been established that the midbrain periaqueductal gray matter (PAG) and rostral ventro-medial medulla (RVM) are involved in the descending pain control system. The latter involves the midline nucleus raphe magnus (NRM) and adjacent reticular formation. These brain structures are is one of important parts of CNS circuit that controls nociceptive transmission at the level of spinal cord. Here we report that microinjection of commonly used non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac, ketorolac, metamizol, and xefocam into the NRM produces strong antinociception which is mediated by the opioid mechanism...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28570221/nasal-ketorolac-challenge-using-acoustic-rhinometry-in-patients-with-aspirin-exacerbated-respiratory-disease
#17
J Quiralte-Castillo, M R Ávila-Castellano, S Cimbollek, P Benaixa, S Leguisamo, K Baynova, M Labella, J Quiralte
BACKGROUND AND OBJECTIVE: Safer and less time-consuming alternatives to single-blind placebo-controlled oral challenge (SBPCOC) have been sought for the diagnosis of aspirin-exacerbated respiratory disease (AERD). Nasal challenges with various nonsteroidal anti-inflammatory drugs and assessment methods have been developed. Objective: Our objective was to evaluate the utility and safety of nasal ketorolac challenge (NKC) using acoustic rhinometry in patients with suspected AERD. METHODS: The study population comprised 36 patients with suspected AERD...
June 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28564673/postoperative-multimodal-analgesia-pain-management-with-nonopioid-analgesics-and-techniques-a-review
#18
Elizabeth C Wick, Michael C Grant, Christopher L Wu
Importance: Amid the current opioid epidemic in the United States, the enhanced recovery after surgery pathway (ERAS) has emerged as one of the best strategies to improve the value and quality of surgical care and has been increasingly adopted for a broad range of complex surgical procedures. The goal of this article was to outline important components of opioid-sparing analgesic regimens. Observations: Regional analgesia, acetaminophen, nonsteroidal anti-inflammatory agents, gabapentinoids, tramadol, lidocaine, and/or the N-methyl-d-aspartate class of glutamate receptor antagonists have been shown to be effective adjuncts to narcotic analgesia...
July 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28540502/developing-transdermal-applications-of-ketorolac-tromethamine-entrapped-in-stimuli-sensitive-block-copolymer-hydrogels
#19
Mireia Mallandrich, Francisco Fernández-Campos, Beatriz Clares, Lyda Halbaut, Cristina Alonso, Luisa Coderch, Maria L Garduño-Ramírez, Berenice Andrade, Alfonso Del Pozo, Majella E Lane, Ana C Calpena
PURPOSE: In order to obtain dermal vehicles of ketorolac tromethamine (KT) for the local treatment of inflammation and restrict undesirable side effects of systemic levels hydrogels (HGs) of poloxamer and carbomer were developed. METHODS: KT poloxamer based HG (KT-P407-HG) and KT carbomer based HG (KT-C940-HG) were elaborated and characterized in terms of swelling, degradation, porosity, rheology, stability, in vitro release, ex vivo permeation and distribution skin layers...
August 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28532934/effects-of-topical-ketorolac-tromethamine-0-45-on-intraoperative-miosis-and-prostaglandin-e2-release-during-femtosecond-laser-assisted-cataract-surgery
#20
Jong Hwa Jun, Young-Sik Yoo, Sung A Lim, Choun-Ki Joo
PURPOSE: To determine the effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 (PGE2) release during femtosecond laser-assisted cataract surgery. SETTING: Seoul St. Mary's Hospital, Seoul, Korea. DESIGN: Prospective case series. METHODS: The study comprised the following 3 groups: conventional cataract surgery without topical NSAIDs (conventional group); femtosecond laser-assisted cataract surgery with preoperative topical ketorolac tromethamine 0...
April 2017: Journal of Cataract and Refractive Surgery
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