keyword
MENU ▼
Read by QxMD icon Read
search

Ketorolac

keyword
https://www.readbyqxmd.com/read/29317798/visual-outcomes-efficacy-and-surgical-complications-associated-with-intracameral-phenylephrine-1-0-ketorolac-0-3-administered-during-cataract-surgery
#1
Eric D Rosenberg, Alanna S Nattis, David Alevi, Rachel L Chu, Joseph Bacotti, Ronald J LoPinto, Gerald D'Aversa, Eric D Donnenfeld
Aim: The purpose of this study was to compare visual outcomes, surgical time, and perioperative surgical complications after intracameral use of either phenylephrine/ketorolac (P/K) or epinephrine (Epi) during cataract surgery. Methods: This was a single-center, retrospective case review of patients undergoing cataract surgery from August to November 2015. Of the 641 eyes of 389 patients who underwent cataract surgery, 260 eyes were administered phenylephrine 1...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29304875/antinociceptive-tolerance-to-nsaids-in-the-anterior-cingulate-cortex-is-mediated-via-endogenous-opioid-mechanism
#2
Nana Tsiklauri, Natia Pirkulashvili, Ivliane Nozadze, Marina Nebieridze, Gulnaz Gurtskaia, Elene Abzianidze, Merab G Tsagareli
BACKGROUND: In the past decade several studies have reported that in some brain areas, particularly, in the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. Given this evidence, in this study we investigated the development of tolerance to the analgesic effects of NSAIDs diclofenac, ketorolac and xefocam microinjected into the rostral part of anterior cingulate cortex (ACC) in rats...
January 6, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29247538/narrative-review-shows-that-the-short-term-use-of-ketorolac-is-safe-and-effective-in-the-management-of-moderate-to-severe-pain-in-children
#3
REVIEW
Pierluigi Marzuillo, Lorenzo Calligaris, Stefano Amoroso, Egidio Barbi
In June 2013, the European Medicine Agency recommended limiting codeine use in paediatric patients, creating a void in managing moderate pain. We reviewed literature published in English (1985-June 2017) on the pharmacokinetic, pharmacodynamic and safety profile of ketorolac, a possible substitute for codeine and opioids, for treating moderate to severe pain. We found that gastrointestinal side effects were mainly reported with prolonged use, significant bleeding was reported in adenotonsillectomies and adverse renal effects appeared to be limited to patients with specific coexisting risk factors...
December 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29229151/ketorolac-use-may-increase-risk-of-postoperative-pancreatic-fistula-after-pancreaticoduodenectomy
#4
Stacy J Kowalsky, Mazen S Zenati, Jennifer Steve, Kenneth K Lee, Melissa E Hogg, Herbert J Zeh, Amer H Zureikat
BACKGROUND: Ketorolac (Toradol), a commonly used nonselective nonsteroidal anti-inflammatory drug (NSAID) in the postoperative period, has been associated with increased risk of anastomotic leak after colon resection. The effect of postoperative NSAID and ketorolac use on postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) is unknown. METHODS: Retrospective review of consecutive PDs at a high-volume pancreas center from 2012 to 2015. POPF was identified and graded using International Study Group on Pancreatic Fistula criteria...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29227185/alternative-drug-delivery-for-patients-undergoing-cataract-surgery-as-demonstrated-in-a-canine-model
#5
L David Waterbury
PURPOSE: (1) To determine ketorolac concentrations in selected ocular tissues following the intracameral administration of phenylephrine and ketorolac injection 1%/0.3% (OMIDRIA®) delivered in irrigation solution during lens replacement surgery in beagle dogs. (2) To compare the ketorolac initial dose and resultant concentrations from the above study to those achieved in aqueous and vitreous by topical administration in patients undergoing cataract surgery or vitrectomy, respectively...
December 11, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29226726/mucosal-co-delivery-of-ketorolac-and-lidocaine-using-polymeric-wafers-for-dental-application
#6
Gina S El-Feky, Rania Farouk Abdulmaguid, Gamal M Zayed, Rabab Kamel
The current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinylpyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy. Nine ketorolac/lidocaine lyophilized wafers were formulated and assessed for their hydration capacity, mucoadhesion ability and in vitro release profile to select the optimum system for further clinical investigation. Wafer F6 containing 2:1 sodium alginate to PVP K-25 and 10% glycerol showed optimum properties and was selected for the clinical study...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29225744/a-comparison-between-ketorolac-and-nefopam-as-adjuvant-analgesics-for-postoperative-patient-controlled-analgesia-a-randomized-double-blind-prospective-study
#7
Ji-Seon Son, Aram Doo, Young-Jun Kwon, Young-Jin Han, Seonghoon Ko
Background: We compared the analgesic efficacy and side effects of ketorolac and nefopam that were co-administered with fentanyl via intravenous patient-controlled analgesia. Methods: One hundred and sixty patients scheduled for laparoscopic cholecystectomy were randomly assigned to ketorolac (Group K) or nefopam (Group N) groups. The anesthetic regimen was standardized for all patients. The analgesic solution contained fentanyl 600 µg and ketorolac 180 mg in Group K, and fentanyl 600 µg and nefopam 120 mg in Group N...
December 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29207772/comparison-of-pain-relief-from-different-intravenous-doses-of-ketorolac-after-reduction-of-mandibular-fractures
#8
Saeed Nezafati, Reza Khorshidi Khiavi, Seyyed Sina Mirinejhad, Dawood Aghamoh Ammadi, Milad Ghanizadeh
Introduction: Pain is an unpleasant feeling due to tissue destruction, which disturbs an individual's daily routines even at its lowest levels. The majority of surgeons and anaesthesiologists are increasingly trying to administer non-opioid analgesics because excessive use of opioids after surgery results in patient dissatisfaction. Aim: To evaluate the analgesic effect of intravenous injection of different doses of ketorolac at different intervals in patients undergoing surgery for unilateral fractures of the mandible...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29194065/delayed-respiratory-depression-secondary-to-opioid-overdose-after-multimodal-analgesia-with-transversus-abdominis-plane-blocks-in-postanesthesia-care-unit-a-case-report
#9
Michael O'Rourke, Emily S Schmidt, Jonathan E Metry, Michael B Majewski
Pain control after open abdominal surgery often includes multimodal analgesia with thoracic epidural or transversus abdominis plane (TAP) block. After liposomal bupivacaine was approved for TAP blocks in 2015, it became an alternative to indwelling catheters. However, the pharmacokinetics and safety of its use during the perioperative period have not been thoroughly investigated, especially in conjunction with parenteral opioids. We present a case report of an elderly patient having urgent laparoscopic converted to open abdominal surgery, who experienced postoperative respiratory depression in the recovery room after multimodal therapy with liposomal bupivacaine TAP blocks, intravenous (IV) opioids, and ketorolac...
November 30, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29187701/association-between-concomitant-use-of-acyclovir-or-valacyclovir-with-nsaids-and-an-increased-risk-of-acute-kidney-injury-data-mining-of-fda-adverse-event-reporting-system
#10
Zhihua Yue, Jinhai Shi, Haona Li, Huiyi Li
NSAIDs are likely to be used concomitantly with acyclovir or valacyclovir in clinical practice, but the study on the safety of such combinations was seldom reported. The objective of the study was to investigate reports of acute kidney injury(AKI) events associated with the concomitant use of oral acyclovir or valacyclovir with an NSAID by using the United States Food and Drug Administration(FDA) Adverse Event Reporting System (AERS) database between January 2004 and June 2012. The frequency of AKI events in patients while simultaneously taking either acyclovir or valacyclovir and an NSAID was compared using the Chi-square test...
November 28, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29173273/incidence-of-bleeding-in-children-undergoing-circumcision-with-ketorolac-administration
#11
Bruce Gao
INTRODUCTION: Circumcision is the most common surgical procedure performed by pediatric urologists. Ketorolac has been shown to have an efficacy similar to morphine in multimodal analgesic regimens without the commonly associated adverse effects. Concerns with perioperative bleeding limit the use of ketorolac as an adjunct for pain control in surgical patients. As such, we sought to evaluate our institutional outcomes with respect to ketorolac and postoperative bleeding. METHODS: We retrospectively reviewed all pediatric patients undergoing circumcision from January 1, 2014 to December 31, 2015 at the Alberta Children's Hospital...
December 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29170308/11%C3%A2-topical-nsaids-for-analgesia-in-traumatic-corneal-abrasions-a-systematic-review-and-meta-analysis
#12
Annali Lawrenson, Abel Wakai
BACKGROUND: Traumatic corneal abrasions are common ocular presenTations in the ED. There is no consensus regarding the most appropriate analgesia for this condition. Topical non-steroidal anti-inflammatory drugs (NSAIDs) have been suggested as pain-relief to minimise systemic adverse events associated with oral analgesia. AIM: To identify and evaluate all randomised controlled trials (RCTs) comparing the use of topical NSAIDs with placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions (including corneal abrasions arising from foreign body removal), to reduce pain, and its effects on healing time...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29169987/the-r-enantiomer-of-ketorolac-delays-mammary-tumor-development-in-mouse-mammary-tumor-virus-polyoma-middle-t-antigen-mmtv-pymt-mice
#13
Amanda S Peretti, Dayna Dominguez, Martha M Grimes, Helen J Hathaway, Eric R Prossnitz, Melanie R Rivera, Angela Wandinger-Ness, Donna F Kusewitt, Laurie G Hudson
Epidemiologic studies report improved breast cancer survival in women receiving ketorolac (Toradol®) for post-operative pain relief compared to other analgesics. Ketorolac is a racemic drug. The S-enantiomer inhibits cyclooxygenases; R-ketorolac is a selective inhibitor of the small GTPases Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), which are signaling molecules up-regulated during breast cancer progression and metastasis. our goal was to determine whether R-ketorolac altered breast cancer development in the mouse mammary tumor virus-polyoma middle T-antigen (MMTV-PyMT) model...
November 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29163153/ketogal-a-derivative-ketorolac-molecule-with-minor-ulcerogenic-and-renal-toxicity
#14
Roberto Russo, Carmen De Caro, Bice Avallone, Salvatore Magliocca, Maria Nieddu, Gianpiero Boatto, Roberta Troiano, Rosario Cuomo, Carla Cirillo, Carmen Avagliano, Claudia Cristiano, Giovanna La Rana, Giovanni Sarnelli, Antonio Calignano, Maria G Rimoli
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the high incidence of gastrointestinal and kidney side events. In our previous study, we demonstrated that ketorolac-galactose conjugate (ketogal), synthesized and tested in a single-dose study, was able to reduce ulcerogenicity, while preserving the high pharmacological efficacy of its parent drug...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29153730/effect-of-a-combination-of-intranasal-ketorolac-and-nitrous-oxide-on-the-success-of-the-inferior-alveolar-nerve-block-in-patients-with-symptomatic-irreversible-pulpitis-a-prospective-randomized-double-blind-study
#15
Daniel Stentz, Melissa Drum, Al Reader, John Nusstein, Sara Fowler, Mike Beck
INTRODUCTION: Previous studies in patients with irreversible pulpitis have reported increased success of the inferior alveolar nerve block (IANB) using premedication with ketorolac. Preemptive nitrous oxide administration has also shown an increase in the success of the IANB. Recently, ketorolac has been made available for intranasal delivery. Perhaps combining ketorolac and nitrous oxide would increase success. Therefore, the purpose of this prospective, randomized, double-blind study was to determine the effect of a combination of intranasal ketorolac and nitrous oxide/oxygen on the anesthetic success of the IANB in patients presenting with symptomatic irreversible pulpitis...
November 15, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29142546/comparison-of-analgesic-effect-of-preoperative-topical-diclofenac-versus-ketorolac-on-postoperative-pain-after-corneal-collagen-cross-linkage
#16
Murtaza Sameen, Muhammad Saim Khan, Asad Habib, Muhammad Amer Yaqub, Mazhar Ishaq
Objective: To compare post-operative pain relieving effect of topical diclofenac 0.1% versus ketorolac 0.5% in Corneal Collagen Cross Linking (CXL) for patients diagnosed with keratoconus. Methods: This randomized controlled trial was carried out for six months from October 2016 to March 2017. We included young patients having keratoconus with k-readings greater than 47D and central corneal thickness more than 400 microns. All the patients received single dose one drop of topical diclofenac 0...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29134504/ketorolac-and-other-nsaids-increase-the-risk-of-anastomotic-leakage-after-surgery-for-gej-cancers-a-cohort-study-of-557-patients
#17
Kaare Terp Fjederholt, Cecilie Okholm, Lars Bo Svendsen, Michael Patrick Achiam, Jakob Kirkegård, Frank Viborg Mortensen
OBJECTIVE: The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer. Within the last two decades, the incidence of gastro-esophageal-junction cancer has increased in the western world and surgery is the curative treatment modality of choice. Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality...
November 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29123376/intracameral-ketorolac-concentration-at-the-beginning-and-end-of-cataract-surgery-following-preoperative-topical-ketorolac-administration
#18
Douglas A Katsev, Cailyn C Katsev, Jen Pinnow, Catherine M Lockhart
Purpose: To evaluate the intracameral concentration of ketorolac tromethamine (ketorolac) at the beginning and end of cataract surgery following preoperative topical administration. Setting: Santa Barbara Surgery Center, Santa Barbara, CA, USA. Design: This was a pre-post, interventional, single-arm study. Patients and methods: Patients undergoing cataract extraction and lens replacement (CELR) were eligible. Written informed consent was obtained from 14 patients who were prescribed topical ophthalmic ketorolac according to the surgeon's usual practice beginning the day prior to surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29120007/incidence-of-heterotopic-ossification-following-a-multimodal-pain-protocol-in-total-hip-arthroplasty-with-the-posterior-approach
#19
Peter B White, Prem N Ramkumar, Morteza Meftah, Narges Ghazi, Amar S Ranawat, Chitranjan S Ranawat
Heterotopic ossification (HO) is prevalent after total hip arthroplasty (THA). Oral nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors have reduced the incidence of HO; however, to the authors' knowledge, no studies have reported the incidence and severity of HO with a pain protocol highlighted by celecoxib in the pre- and postoperative period with a posterolateral approach. Between October 2014 and October 2015, a retrospective study was conducted of 687 consecutive primary THAs with minimum 1-year follow-up performed between January 2009 and December 2013...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29118499/causes-and-management-of-small-pupil-in-patients-with-cataract
#20
Ioannis Halkiadakis, Irini Chatziralli, Evangelos Drakos, Michail Katzakis, Sotirios Skouriotis, Eleni Patsea, Panagiotis Mitropoulos, Artemios Kandarakis
BACKGROUND: The purpose of the study was to present the causes and management of small pupil (<6 mm) in Greek patients with cataract. METHODS: About 1144 consecutive patients with cataract comprised the study group. The pupil size was measured after maximal dilation by means of Rosenbaum cards and Colvard pupillometer. Dilation regimen included phenylephrine 10%, tropicamide 1%, cyclopentolate 1%, and ketorolac trometamol 0.5% administered 3 times at 5 min intervals starting 1 h before surgery...
September 2017: Oman Journal of Ophthalmology
keyword
keyword
44910
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"