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Ketorolac

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https://www.readbyqxmd.com/read/29142546/comparison-of-analgesic-effect-of-preoperative-topical-diclofenac-versus-ketorolac-on-postoperative-pain-after-corneal-collagen-cross-linkage
#1
Murtaza Sameen, Muhammad Saim Khan, Asad Habib, Muhammad Amer Yaqub, Mazhar Ishaq
Objective: To compare post-operative pain relieving effect of topical diclofenac 0.1% versus ketorolac 0.5% in Corneal Collagen Cross Linking (CXL) for patients diagnosed with keratoconus. Methods: This randomized controlled trial was carried out for six months from October 2016 to March 2017. We included young patients having keratoconus with k-readings greater than 47D and central corneal thickness more than 400 microns. All the patients received single dose one drop of topical diclofenac 0...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29134504/ketorolac-and-other-nsaids-increase-the-risk-of-anastomotic-leakage-after-surgery-for-gej-cancers-a-cohort-study-of-557-patients
#2
Kaare Terp Fjederholt, Cecilie Okholm, Lars Bo Svendsen, Michael Patrick Achiam, Jakob Kirkegård, Frank Viborg Mortensen
OBJECTIVE: The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer. Within the last two decades, the incidence of gastro-esophageal-junction cancer has increased in the western world and surgery is the curative treatment modality of choice. Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality...
November 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29123376/intracameral-ketorolac-concentration-at-the-beginning-and-end-of-cataract-surgery-following-preoperative-topical-ketorolac-administration
#3
Douglas A Katsev, Cailyn C Katsev, Jen Pinnow, Catherine M Lockhart
Purpose: To evaluate the intracameral concentration of ketorolac tromethamine (ketorolac) at the beginning and end of cataract surgery following preoperative topical administration. Setting: Santa Barbara Surgery Center, Santa Barbara, CA, USA. Design: This was a pre-post, interventional, single-arm study. Patients and methods: Patients undergoing cataract extraction and lens replacement (CELR) were eligible. Written informed consent was obtained from 14 patients who were prescribed topical ophthalmic ketorolac according to the surgeon's usual practice beginning the day prior to surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29120007/incidence-of-heterotopic-ossification-following-a-multimodal-pain-protocol-in-total-hip-arthroplasty-with-the-posterior-approach
#4
Peter B White, Prem N Ramkumar, Morteza Meftah, Narges Ghazi, Amar S Ranawat, Chitranjan S Ranawat
Heterotopic ossification (HO) is prevalent after total hip arthroplasty (THA). Oral nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors have reduced the incidence of HO; however, to the authors' knowledge, no studies have reported the incidence and severity of HO with a pain protocol highlighted by celecoxib in the pre- and postoperative period with a posterolateral approach. Between October 2014 and October 2015, a retrospective study was conducted of 687 consecutive primary THAs with minimum 1-year follow-up performed between January 2009 and December 2013...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29118499/causes-and-management-of-small-pupil-in-patients-with-cataract
#5
Ioannis Halkiadakis, Irini Chatziralli, Evangelos Drakos, Michail Katzakis, Sotirios Skouriotis, Eleni Patsea, Panagiotis Mitropoulos, Artemios Kandarakis
BACKGROUND: The purpose of the study was to present the causes and management of small pupil (<6 mm) in Greek patients with cataract. METHODS: About 1144 consecutive patients with cataract comprised the study group. The pupil size was measured after maximal dilation by means of Rosenbaum cards and Colvard pupillometer. Dilation regimen included phenylephrine 10%, tropicamide 1%, cyclopentolate 1%, and ketorolac trometamol 0.5% administered 3 times at 5 min intervals starting 1 h before surgery...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29102918/non-steroidal-anti-inflammatory-drugs-attenuate-agonist-evoked-activation-of-transient-receptor-potential-channels
#6
M G Tsagareli, I Nozadze, N Tsiklauri, G Gurtskaia
Transient receptor potential (TRP) cation channels are the largest group of sensory detector proteins expressed in the nerve terminals of many receptors including nociceptors, and are activated by temperature and chemicals that elicit hot or cold sensations. Antagonists of these channels are likely promising targets for new analgesic drugs at the peripheral and central levels. Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels...
November 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29101812/the-effect-of-ketorolac-and-triamcinolone-acetonide-on-adipogenic-and-hepatogenic-differentiation-through-mirnas-16-15-195-possible-clinical-application-in-regenerative-medicine
#7
Sedigheh Fekri Aval, Nosratollah Zarghami, Effat Alizadeh, Seyed Abolghasem Mohammadi
OBJECTIVE: The role of miR-16/15b/195 and complementary compounds in the commitment of mesenchymal stem cells (MSCs) to different lineages is unknown. The aim of this work was to investigate the effect of ketorolac and triamcinolone acetonide on adipogenic and hepatogenic processes, respectively. Also, miR-16/15 and miR-195 expression levels were evaluated under different induction conditions. METHODS: MSCs were isolated, expanded and directed using adipogenesis medium or medium supplemented with ketorolac, and also subjected to hepatogenic differentiation using a cocktail of hepatocyte growth factor (HGF) and Oncostatin M (OSM) either with or without triamcinolone acetonide...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080492/stability-indicating-hplc-dad-method-for-analysis-of-ketorolac-binary-and-ternary-mixtures-in-eye-drops-quantitative-analysis-in-rabbit-aqueous-humor
#8
Fawzy A El Yazbi, Ekram M Hassan, Essam F Khamis, Marwa A A Ragab, Mohamed M A Hamdy
Ketorolac tromethamine (KTC) with phenylephrine hydrochloride (PHE) binary mixture (mixture 1) and their ternary mixture with chlorpheniramine maleate (CPM) (mixture 2) were analyzed using a validated HPLC-DAD method. The developed method was suitable for the in vitro as well as quantitative analysis of the targeted mixtures in rabbit aqueous humor. The analysis in dosage form (eye drops) was a stability indicating one at which drugs were separated from possible degradation products arising from different stress conditions (in vitro analysis)...
October 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29075132/urinary-protein-profiles-in-ketorolac-associated-acute-kidney-injury-in-patients-undergoing-orthopedic-day-surgery
#9
Filippo Mariano, Chiara Cogno, Fulvia Giaretta, Ilaria Deambrosis, Simona Pozza, Maurizio Berardino, Giuseppe Massazza, Luigi Biancone
BACKGROUND: Parenteral administration of ketorolac is very effective in controlling postoperative pain for orthopedic surgery. Ketorolac can induce clinically relevant renal alterations in elderly patients, whereas its short course is considered safe for young adults with normal preoperative renal function. In this study, of a cohort of young adults undergoing elective orthopedic day surgery, we sought cases complicated by readmission due to acute kidney injury (AKI). PATIENTS AND METHODS: Among 1397 young adults, aged 18-32 years who were admitted to undergo orthopedic day surgery from 2013 to 2015, four patients (0...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29065741/intra-incisional-liposomal-bupivacaine-and-its-impact-on-post-cesarean-analgesia-a-retrospective-study
#10
Pavan Parikh, Imran Sunesara, Sukhpreet Singh Multani, Brandy Patterson, Elizabeth Lutz, James N Martin
PURPOSE: The efficacy of long acting intra-incisional bupivacaine in reducing postoperative opioid use amongst women who have undergone a cesarean is currently unknown. MATERIALS AND METHODS: This was a retrospective case-control study with a 1:1 allocation. We identified 40 patients in each group, for a total of 80. The treatment group was administered 266 mg of liposomal bupivacaine after completion of the cesarean and was compared to historical controls. Data regarding anesthesia administered, opioid consumption, nonsteroidal anti-inflammatory use, acetaminophen use, type of cesarean, reason for cesarean and length of postoperative stay were recorded...
October 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29059223/evaluation-of-a-novel-biodegradable-thermosensitive-keto-hydrogel-for-improving-postoperative-pain-in-a-rat-model
#11
Meng-Huang Wu, Ming-Hung Shih, Wei-Bin Hsu, Navneet Kumar Dubey, Wen-Fu Lee, Tsai-Yu Lin, Meng-Yow Hsieh, Chin-Fu Chen, Kuo-Ti Peng, Tsung-Jen Huang, Chung-Sheng Shi, Ren-Shyang Guo, Chang-Jhih Cai, Chiu-Yen Chung, Chung-Hang Wong
This study evaluates the sustained analgesic effect of ketorolac-eluting thermosensitive biodegradable hydrogel in the plantar incisional pain model of the rat hind-paw. A ketorolac-embedded 2, 2'-Bis (2-oxazolin) (BOX) linking methoxy-poly(ethylene glycol) and poly(lactide-co-glycolide) (mPEG-PLGA) diblock copolymer (BOX copolymer) was synthesized as keto-hydrogel based on optimal sol-gel phase transition and in vitro drug release profile. The effect of keto-hydrogel on postoperative pain (POP) was assessed using the established plantar incisional pain model in hind-paw of rats and compared to that of ketorolac solution...
2017: PloS One
https://www.readbyqxmd.com/read/29052805/sublingual-buprenorphine-efficacy-in-renal-colic-pain-relief-a-randomized-placebo-controlled-clinical-trial
#12
Javad Mozafari, Kambiz Masoumi, Arash Forouzan, Hassan Motamed, Malehi Amal Saki, Marzieh Dezham
INTRODUCTION: This study was designed to compare the analgesic efficacy of sublingual (SL) buprenorphine and intravenous (IV) ketorolac for renal colic pain relief. METHODS: The present study was carried out as a double-blind, double-dummy randomized clinical trial in patients diagnosed with acute renal colic attending the emergency department. The study subjects were 63 patients with confirmed renal stones. The subjects were randomly divided into two groups. One group, which included 32 patients, received SL buprenorphine tablets (2 mg) with an IV placebo, and another group, including 31 patients, received ketorolac tromethamine (30 mg) with a SL placebo...
October 20, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29048209/percuflex-helical-sup-tm-sup-ureteral-stents-significantly-reduce-patient-analgesic-requirements-compared-to-control-stents
#13
Ben H Chew, Karla A Rebullar, David Harriman, Elspeth M McDougall, Ryan F Paterson, Dirk Lange
INTRODUCTION AND OBJECTIVES: Ureteral stent symptoms are experienced by the majority of patients with ureteral stents. No one stent or technology has shown a clear advantage.  The Helical<sup>TM</sup> stent, a spirally cut stent made of proprietary Percuflex<sup>TM</sup> material was designed to conform to the shape of the ureter and better accommodate patient movement.  We prospectively sought to compare unscheduled visits, analgesic use and pain scores in patients who received a Percuflex Helical ureteral stent following ureteroscopy compared to a historical control group...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29037195/comparison-between-xcelligence-biosensor-technology-and-conventional-cell-culture-system-for-real-time-monitoring-human-tenocytes-proliferation-and-drugs-cytotoxicity-screening
#14
Chih-Hao Chiu, Kin Fong Lei, Wen-Ling Yeh, Poyu Chen, Yi-Sheng Chan, Kuo-Yao Hsu, Alvin Chao-Yu Chen
BACKGROUND: Local injections of anesthetics, NSAIDs, and corticosteroids for tendinopathies are empirically used. They are believed to have some cytotoxicity toward tenocytes. The maximal efficacy dosages of local injections should be determined. A commercial 2D microfluidic xCELLigence system had been developed to detect real-time cellular proliferation and their responses to different stimuli and had been used in several biomedical applications. The purpose of this study is to determine if human tenocytes can successfully proliferate inside xCELLigence system and the result has high correlation with conventional cell culture methods in the same condition...
October 16, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29028762/intermittent-versus-continuous-and-intermittent-medications-for-pain-and-sedation-after-pediatric-cardiothoracic-surgery-a-randomized-controlled-trial
#15
Jamie S Penk, Cheryl A Lefaiver, Colleen M Brady, Christine M Steffensen, Kimberly Wittmayer
OBJECTIVES: Compare continuous infusions of morphine and midazolam in addition to intermittent doses with an intermittent only strategy for pain and sedation after pediatric cardiac surgery. DESIGN: Randomized controlled trial. SETTING: Advocate Children's Hospital, Oak Lawn, IL. PATIENTS: Sixty patients 3 months to 4 years old with early extubation after pediatric cardiac surgery. INTERVENTIONS: Patients received a continuous infusion of morphine and midazolam or placebo for 24 hours...
October 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29026810/the-role-of-local-bupivacaine-irrigation-in-postoperative-pain-control-after-augmentation-mammoplasty-a-systematic-review-and-meta-analysis
#16
Shan Shan Qiu, Marta Roque, Yi-Chieh Chen
BACKGROUND: The objective of this study is to analyze the efficacy of local bupivacaine irrigation after augmentation mammoplasty for the control of postoperative pain. METHODS: A systematic review and meta-analysis was conducted including all randomized controlled trials (RCTs) that compared the irrigation of bupivacaine (±ketorolac) versus normal saline or no irrigation for pain control after breast augmentation. The primary outcome was postoperative pain measured by visual analog scale...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/28993164/pre-emptive-ketorolac-for-prevention-of-intraoperative-shoulder-pain-in-patients-undergoing-cesarean-section-a-double-blind-randomized-clinical-trial
#17
Mostafa Samy Abbas, Omnia Ahmed Askar, Ahmed Ali Abdel Aleem
BACKGROUND: Shoulder pain is a commonly observed but mostly neglected consequence of cesarean section and little is known as well as explored about intraoperative shoulder pain. We conducted this randomized prospective double-blinded study to evaluate the efficacy of ketorolac in reducing the incidence and severity of intraoperative shoulder pain in patients undergoing cesarean section. METHODS: Two hundred ASA I and II patients scheduled to undergo elective cesarean section under spinal anesthesia were randomized to receive either intravenous ketorolac 30 mg (ketorolac group) or normal saline (control group)...
September 20, 2017: Asian J Anesthesiol
https://www.readbyqxmd.com/read/28987613/treatment-of-cystoid-macular-edema-secondary-to-retinitis-pigmentosa-a-systematic-review
#18
REVIEW
Malini Bakthavatchalam, Frank H P Lai, Shi Song Rong, Danny S Ng, Marten E Brelen
There are various treatments for cystoid macular edema (CME) secondary to retinitis pigmentosa (RP); however, the evidence for these treatments has not been previously systematically reviewed. Our review that includes 23 studies shows that oral carbonic anhydrase inhibitors (CAI) (including acetazolamide, methazolamide) and topical CAI (dorzolamide and brinzolamide) are effective first line treatments. In patients unresponsive to CAI treatment, intravitreal steroids (triamcinolone acetonide and sustained-release dexamethasone implant), oral corticosteroid (Deflazacort), intravitreal anti-vascular endothelial growth factor agents (ranibizumab and bevacizumab), grid laser photocoagulation, pars plana vitrectomy, or ketorolac were also effective in improving CME secondary to RP...
October 4, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28985855/safety-of-perioperative-ketorolac-administration-in-pediatric-appendectomy
#19
Hibbut-Ur-Rauf Naseem, Robert Michael Dorman, George Ventro, David H Rothstein, Kaveh Vali
BACKGROUND: Recent studies in adults undergoing gastrointestinal surgeries show an increased rate of complications with the use of ketorolac. This calls into question the safety of ketorolac in certain procedures. We sought to evaluate the impact of perioperative ketorolac administration on outcomes in pediatric appendectomy. METHODS: The Pediatric Health Information System database was queried for patients aged 5-17 y with a primary diagnosis of appendicitis and a primary procedure of appendectomy during the period 2010-2014...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28975070/paracetamol-instead-of-ketorolac-in-post-video-assisted-thoracic-surgery-pain-management-a-randomized-trial
#20
Alireza Jahangiri Fard, Behrooz Farzanegan, Ali Khalili, Nejatali Ebrahimi Ahmadabad, Abolghasem Daneshvar Kakhaki, Tahereh Parsa, Maziyar Mahjoobifard, Mohammad Khabiri, Majid Golestani Eraghi
BACKGROUND: Video-assisted thoracic surgery (VATS) is a minimally invasive procedure that is growing more common around the world. Despite causing less pain compared open thoracic surgery, postoperative pain management is still important. OBJECTIVES: The aim of the present study was to compare the analgesic effects of paracetamol and ketorolac in VATS patients. METHODS: This was a double-blinded randomized clinical trial conducted on 70 patients undergoing lobectomy or segmentectomy due to lung masses, using video-assisted methods...
December 2016: Anesthesiology and Pain Medicine
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