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Ketorolac

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https://www.readbyqxmd.com/read/28429492/body-weight-gender-and-pregnancy-affect-enantiomer-specific-ketorolac-pharmacokinetics
#1
Pyry A Välitalo, Heidi Kemppainen, Aida Kulo, Anne Smits, Kristel van Calsteren, Klaus T Olkkola, Jan de Hoon, Catherijne A J Knibbe, Karel Allegaert
AIMS: Although ketorolac analgesia is linked only to the S-enantiomer, there is limited information on the stereo-selective pharmacokinetics of ketorolac. We studied the stereo-selective pharmacokinetics of ketorolac in a pooled dataset of two studies, with women at delivery and 4-5 months postpartum, and males and non-pregnant females. METHODS: Non-linear mixed effect modeling was used to evaluate stereo-selective pharmacokinetics of ketorolac tromethamine after single intravenous injection immediately after delivery (n = 41), 4-5 months postpartum (n = 8, paired), and in non-pregnant female (n = 14) and male (n = 12) subjects...
April 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28420308/nanodispersion-loaded-mucoadhesive-polymeric-inserts-for-prolonged-treatment-of-postoperative-ocular-inflammation
#2
Nadia Morsi, Dalia Ghorab, Hanan Refai, Hoda Teba
Mucoadhesive polymeric films incorporated with ketorolac tromethamine loaded nanodispersion aiming the sustained delivery of the drug to the cornea have been developed and characterized for the treatment of postoperative ocular inflammation. Nanodispersions were prepared by ionic gelation method with various concentrations of chitosan and sodium tripolyphosphate. The developed nanodispersions were analyzed for morphology, particle size, dispersion homogeneity, zeta potential, entrapment efficiency and drug release...
April 19, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28418546/in-patients-in-the-emergency-department-with-acute-pain-10-15-and-30-mg-of-ketorolac-did-not-differ-for-pain-relief
#3
Christopher R Carpenter
No abstract text is available yet for this article.
April 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28408853/tumescent-mastectomy-the-current-indications-and-operative-tips-and-tricks
#4
Ashraf Khater, Alaa Mazy, Mona Gad, Ola Taha Abd Eldayem, Mohamed Hegazy
BACKGROUND: Tumescent mastectomy refers to usage of a mixture of lidocaine and epinephrine in a diluting saline solution that makes flaps firm and tense, thus minimizing systemic drugs toxicity and making surgery possible with minimal bleeding. This technique is very useful in elder women and those with American Society of Anesthesiologists; score III and IV. The objective was to establish an alternative safe technique to general anesthesia in some selected mastectomy patients. PATIENTS AND METHODS: Twenty candidate women for total mastectomy and axillary dissection were enrolled and consented to participate...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28407163/effect-of-topical-nonsteroidal-anti-inflammatory-drugs-on-pupillary-size-during-uncomplicated-cataract-surgery
#5
Alejandro Rodríguez-García, Julio C Hernández-Camarena, Gilberto R López-Jaime, José A Nava-García
PURPOSE: To compare the effectiveness of three different topical nonsteroidal anti-inflammatory drugs (NSAIDs) in inhibiting surgically induced miosis during uncomplicated cataract phacoemulsification. METHODS: Prospective, randomized, double-masked comparative study of patients aged 40 years or older with grades II to III cataracts (Lens Opacities Classification System) and no other comorbidities. Participants were randomized into four groups: 0.1% nepafenac, 0...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28407162/effects-of-short-term-preoperative-topical-ketorolac-on-pupil-diameter-in-eyes-undergoing-femtosecond-laser-assisted-capsulotomy
#6
Vasilios F Diakonis, Georgios A Kontadakis, Apostolos G Anagnostopoulos, Nilufer Yesilirmak, Daniel P Waren, Florence Cabot, Sonia H Yoo, Kendall E Donaldson
PURPOSE: To assess pupil diameter before and after femtosecond laser-assisted capsulotomy in patients who were pretreated with a short-term topical nonsteroidal anti-inflammatory drug (NSAID) (ketorolac) versus those without pretreatment. METHODS: This prospective, randomized, observational case series included consecutive patients scheduled to undergo cataract extraction using the Catalys femtosecond laser platform (Abbott Medical Optics, Inc., Santa Ana, CA) to perform only capsulotomies...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28402744/single-incision-versus-three-port-laparoscopic-appendectomy-short-and-long-term-outcomes
#7
Samatha Vellei, Alessandro Borri
AIM: To compare the outcome of patients who had undergone single-incision laparoscopic appendectomy (SILA) with others who had undergone three-port laparoscopic appendectomy (3-PORT). MATERIALS AND METHODS: Data from all adults with uncomplicated appendicitis treated by laparoscopic appendectomy between June 2012 and December 2015 were prospectively collected. Patients with chronic pain, appendix malignancy, at least two previous laparotomies, and those undergoing concomitant surgery for different condition were excluded from analysis...
April 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28392176/increased-frequency-of-topical-steroids-provides-benefit-in-patients-with-recalcitrant-postsurgical-macular-edema
#8
Peter A Campochiaro, Yong S Han, Tahreem A Mir, Saleema Kherani, Gulnar Hafiz, Claudia Krispel, T Y Alvin Liu, Jiangxia Wang, Adrienne W Scott, Ingrid Zimmer-Galler
PURPOSE: To compare standard and frequent topical steroids for postsurgical macular edema (ME) DESIGN: Randomized clinical trial METHODS: Subjects with postsurgical ME stratified into post-cataract surgery ME (PCSME) and post-other surgery ME (POSME) were randomized to ketorolac four times a day (qid) + 1% prednisolone acetate (PA) every hour while awake (q1hWA, group 1) or qid (group 2). Mean change from baseline best corrected visual acuity (BCVA) was determined at week 12 after which group 2 subjects with persistent edema were crossed over to PA q1hWA...
April 6, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28390888/liposomal-bupivacaine-mixture-has-similar-pain-relief-and-significantly-fewer-complications-at-less-cost-compared-to-indwelling-interscalene-catheter-in-total-shoulder-arthroplasty
#9
William J Weller, Michael G Azzam, Richard A Smith, Frederick M Azar, Thomas W Throckmorton
BACKGROUND: The efficacy and costs of indwelling interscalene catheter (ISC) and liposomal bupivacaine (LBC), with and without adjunctive medications, in patients with primary shoulder arthroplasty are a source of current debate. METHODS: In 214 arthroplasties, 156 patients had ISC and 58 had LBC injections that were mixed with morphine, ketorolac, and 0.5% bupivacaine with epinephrine. Charts were reviewed for visual analog scale pain scores, oral morphine equivalent (OME) usage, major complications, and costs...
March 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28385937/multimodal-infiltration-of-local-anaesthetic-in-total-knee-arthroplasty-is-posterior-capsular-infiltration-worth-the-risk-a-prospective-double-blind-randomised-controlled-trial
#10
P Pinsornsak, S Nangnual, K Boontanapibul
AIMS: Multimodal infiltration of local anaesthetic provides effective control of pain in patients undergoing total knee arthroplasty (TKA). There is little information about the added benefits of posterior capsular infiltration (PCI) using different combinations of local anaesthetic agents. Our aim was to investigate the effectiveness of the control of pain using multimodal infiltration with and without infiltration of the posterior capsule of the knee. PATIENTS AND METHODS: In a double-blind, randomised controlled trial of patients scheduled for unilateral primary TKA, 86 were assigned to be treated with multimodal infiltration with (Group I) or without (Group II) PCI...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28381310/biochemical-histopathologic-physiologic-and-behavioral-effects-of-nonsteroidal-antiinflammatory-drugs-in-rainbow-trout-oncorhynchus-mykiss
#11
Amy L Rizzo, Gregory A Wooster, Luce E Guanzini, Christine M Peterson, Karryssas Fenderson, Hollis N Erb, Paul R Bowser, Mary E Martin
Because the number of fish being used in research is increasing rapidly, evaluating the analgesic and pathologic effects of NSAID in fish is essential. To determine the biochemical, histopathologic, physiologic and behavioral effects of 3 NSAID, 48 rainbow trout underwent anesthesia with tricaine methanesulfonate and exploratory celiotomy and were randomly assigned to receive flunixin (0.5 mg/kg IM), ketorolac (0.5 mg/kg IM), ketoprofen (2 mg/kg IM), or saline. Clinical pathologic variables were assessed 1 wk before surgery and 48 h after surgery...
March 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28375752/local-infiltration-for-postsurgical-analgesia-following-total-hip-arthroplasty-a-comparison-of-liposomal-bupivacaine-to-traditional-bupivacaine
#12
Carl V Asche, Jinma Ren, Minchul Kim, Kate Gordon, Marie McWhirter, Carmen S Kirkness, Brian T Maurer
OBJECTIVE: To assess postsurgical clinical and economic outcomes of patients who received local infiltration containing liposomal bupivacaine versus traditional bupivacaine for pain management following total hip arthroplasty (THA). METHODS: This retrospective study included two groups of consecutive patients undergoing THA. The experimental group received local infiltration with a combination of liposomal bupivacaine, bupivacaine HCl 0.25% with epinephrine 1:200,000, and ketorolac for postsurgical analgesia...
April 4, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28374466/post-operative-pain-relief-using-local-infiltration-analgesia-during-open-abdominal-hysterectomy-a-randomized-double-blind-study
#13
J M Hayden, J Oras, O I Karlsson, K G Olausson, S-E Thörn, A Gupta
BACKGROUND: Post-operative pain is common and often severe after open abdominal hysterectomy, and analgesic consumption high. This study assessed the efficacy of local infiltration analgesia (LIA) injected systematically into different tissues during surgery compared with saline on post-operative pain and analgesia. METHODS: Fifty-nine patients were randomized to Group LIA (n = 29) consisting of 156 ml of a mixture of 0.2% ropivacaine + 30 mg ketorolac + 0.5 mg (5 ml) adrenaline, where the drugs were injected systematically in the operating site, around the proximal vagina, the ligaments, in the fascia and subcutaneously, or to saline and intravenous ketorolac, Group C (Control, n = 28), in a double-blind study...
May 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28372658/a-case-of-paradoxical-presentation-of-a-postural-postdural-puncture-headache-after-combined-spinal-epidural-anesthesia
#14
John W Bordlee, Burton D Beakley, Rayomond Mody, Anne P McConville, Jonathan T Weed, Brian P McClure, Peter J Foldes, Jonathan G Ma, Alan D Kaye, Jonathan P Eskander
We report a case of paradoxical presentation of a postural postdural puncture headache secondary to dural puncture with a 25-gauge Whitacre needle for combined spinal-epidural anesthesia. This 27-year-old female patient presented to the emergency department with elevated blood pressure and a global headache 9 days after administration of epidural anesthesia for a spontaneous vaginal delivery after an uncomplicated pregnancy. The patient reported that the headache was more intense when lying down and immediately improved when she sat or stood up from a recumbent position...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28320541/comparative-evaluation-of-premedication-with-ketorolac-and-prednisolone-on-postendodontic-pain-a-double-blind-randomized-controlled-trial
#15
R Praveen, Sophia Thakur, M Kirthiga
INTRODUCTION: The present clinical trial aimed to evaluate and compare the effect of a single pretreatment dose of ketorolac (20 mg), prednisolone (30 mg), and placebo on postendodontic pain in patients undergoing endodontic therapy for irreversible pulpitis or pulpal necrosis using a visual analog scale. METHODS: Ninety-two subjects were included in the present trial; 46 subjects had a pulpal diagnosis of irreversible pulpitis, and the other 46 had pulpal necrosis...
March 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28315341/low-doses-of-tizanidine-synergize-the-anti-nociceptive-and-anti-inflammatory-effects-of-ketorolac-or-naproxen-while-reducing-of-side-effects
#16
Selene I Patiño-Camacho, Myrna Déciga Campos, Karla Beltrán-Villalobos, Dalia A Castro-Vidal, Rosa M Montiel-Ruiz, Francisco J Flores-Murrieta
The aim of the present study was to determine whether tizanidine, an alpha2-adrenoceptor agonist, is able to increase the anti-inflammatory and anti-nociceptive effects of naproxen and ketorolac with a low incidence of gastric injury and spontaneous activity in rats. The anti-inflammatory effect was assayed in a carrageenan test, and oral administration of tizanidine (ED40 =0.94±0.2mg/kg), naproxen (ED40=3.18±0.4mg/kg), and ketorolac (ED40=16.4±1.9mg/kg) showed a dose-dependent effect on inflammation. The anti-nociceptive effect was assayed in the formalin test, and administration of tizanidine (ED40=0...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28294366/antihyperalgesic-effects-of-indomethacin-ketorolac-and-metamizole-in-rats-effects-of-metformin
#17
Crystell Guadalupe Guzmán-Priego, Roberto Méndez-Mena, Manuel Alfonso Baños-González, Claudia Ivonne Araiza-Saldaña, Gabriela Castañeda-Corral, Jorge Elías Torres-López
Preclinical Research Metformin-dependent mechanisms have been implicated in the antinociceptive effect of some non-steroidal anti-inflammatory drugs (NSAIDs). In this study, the effect of local peripheral or systemic administration of metformin on the local peripheral or systemic antinociception induced by indomethacin, ketorolac and metamizole was assessed in the rat carrageenan-induced thermal hyperalgesia model. Rats were injected with carrageenan (1%, 50 µl) into the right hindpaw which reduced paw withdrawal latency, a measure of thermal hyperalgesia...
March 15, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28286832/the-effect-of-magnesium-sulfate-on-renal-colic-pain-relief-a-randomized-clinical-trial
#18
Abolfazl Jokar, Ali Cyrus, Maryam Babaei, Majid Taheri, Amir Almasi-Hashiani, Ezatollah Behzadinia, Arash Yazdanbakhsh
INTRODUCTION: Renal colic can be managed by preventing the contraction movements of ureter muscles. By reducing acetylcholine in the nerve terminals, magnesium sulfate could be effective in this regard. The aim of this study is to investigate the effect of magnesium sulfate on acute renal colic pain relief. METHOD: The present study was a double-blind clinical trial in which the patients suffering from acute renal colic were randomly divided into 2 groups of who either received standard protocol (intravenous infusion of 0...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28286809/ketorolac-versus-magnesium-sulfate-in-migraine-headache-pain-management-a-preliminary-study
#19
Hossein Delavar Kasmaei, Marzieh Amiri, Ahmed Negida, Samaneh Hajimollarabi, Nastaransadat Mahdavi
INTRODUCTION: Migraine is a common cause of emergency department (ED) visits. To date, there is no recommended drug of choice for pain management of these patients. In the present study, we aimed to evaluate the effectiveness of ketorolac and magnesium sulfate in this regard. METHODS: This is a cross-sectional study performed on all 18 - 60 year-old patients, visiting two different EDs with complaint of moderate to severe migraine headache. Patients were treated with 30 mg ketorolac in one hospital and 1 gram magnesium sulfate in the other...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28279492/group-2-innate-lymphoid-cells-are-recruited-to-the-nasal-mucosa-in-patients-with-aspirin-exacerbated-respiratory-disease
#20
Jacqueline J Eastman, Kellen J Cavagnero, Adam S Deconde, Alex S Kim, Maya R Karta, David H Broide, Bruce L Zuraw, Andrew A White, Sandra C Christiansen, Taylor A Doherty
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by tissue eosinophilia and mast cell activation, including abundant production of prostaglandin D2 (PGD2). Group 2 innate lymphoid cells (ILC2s), which promote tissue eosinophilia and mast cell responses, undergo chemotaxis and cytokine production in response to PGD2, but it is unknown whether ILC2s are active in patients with AERD. OBJECTIVE: We sought to determine whether ILC2 numbers change in peripheral blood and the nasal mucosa during COX-1 inhibitor-induced reactions in patients with AERD...
January 27, 2017: Journal of Allergy and Clinical Immunology
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