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https://www.readbyqxmd.com/read/28204989/assessment-of-noninvasive-predictors-of-bladder-detrusor-underactivity-in-bph-luts-patients
#1
Fei Luo, Hong-Hong Sun, Yan-Hui Su, Zhi-Hua Zhang, Ya-Shen Wang, Zhen Zhao, Jian Li
PURPOSE: To retrospectively assess the diagnostic predictive value of clinical characteristics to improve the diagnostic accuracy of bladder detrusor underactivity (DU) among benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) patients who cannot undergo urodynamic examinations. METHODS: A total of 704 BPH/LUTS patients at Tianjin Medical Union Center from January 2013 through June 2016 were enrolled in the study. All cases were stratified by maximum detrusor pressure (Pdet...
February 15, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28148533/inhibition-of-vascular-smooth-muscle-inward-rectifier-k-channels-restores-myogenic-tone-in-mouse-urinary-bladder-arterioles
#2
Nathan R Tykocki, Adrian D Bonev, Thomas Andrew Longden, Thomas J Heppner, Mark T Nelson
Prolonged decreases in urinary bladder blood flow are linked to overactive and underactive bladder pathologies. However, the mechanisms regulating bladder vascular reactivity are largely unknown. To investigate these mechanisms, we examined myogenic and vasoactive properties of mouse bladder feed arterioles (BFAs). Unlike similar-sized arterioles from other vascular beds, BFAs failed to constrict in response to increases in intraluminal pressure (5-80 mmHg). Consistent with this lack of myogenic tone, arteriolar smooth muscle cell membrane potential was hyperpolarized (-72...
February 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28138557/characterization-of-mirna-regulated-networks-hubs-of-signaling-and-biomarkers-in-obstruction-induced-bladder-dysfunction
#3
Ali Hashemi Gheinani, Bernhard Kiss, Felix Moltzahn, Irene Keller, Rémy Bruggmann, Hubert Rehrauer, Catharine Aquino Fournier, Fiona C Burkhard, Katia Monastyrskaya
Bladder outlet obstruction (BOO) induces significant organ remodeling, leading to lower urinary tract symptoms accompanied by urodynamic changes in bladder function. Here, we report mRNA and miRNA transcriptome sequencing of bladder samples from human patients with different urodynamically defined states of BOO. Patients' miRNA and mRNA expression profiles correlated with urodynamic findings. Validation of RNA sequencing results in an independent patient cohort identified combinations of 3 mRNAs (NRXN3, BMP7, UPK1A) and 3 miRNAs (miR-103a-3p, miR-10a-5p, miR-199a-3p) sufficient to discriminate between bladder functional states...
January 26, 2017: JCI Insight
https://www.readbyqxmd.com/read/28042309/the-link-between-vascular-dysfunction-bladder-ischemia-and-aging-bladder-dysfunction
#4
REVIEW
Karl-Erik Andersson, Donna B Boedtkjer, Axel Forman
The vascular supply to the human bladder is derived mainly from the superior and inferior vesical arteries, the latter being directly connected to the internal iliac artery. Aging is associated with an impairment of blood vessel function and changes may occur in the vasculature at the molecular, cellular and functional level. Pelvic arterial insufficiency may play an important role in the development of bladder dysfunctions such as detrusor overactivity (DO) and the overactive bladder syndrome. Chronic ischemia-related bladder dysfunction may progress to bladder underactivity and it would be desirable to treat not only lower urinary tract symptoms (LUTS) induced by chronic ischemia, but also the progression of the morphological bladder changes...
January 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27958325/onabotulinumtoxina-urethral-sphincter-injection-as-treatment-for-non-neurogenic-voiding-dysfunction-a-randomized-double-blind-placebo-controlled-study
#5
Yuan-Hong Jiang, Chung-Cheng Wang, Hann-Chorng Kuo
Non-neurogenic voiding dysfunction including dysfunctional voiding and detrusor underactivity caused by a spastic or non-relaxing external urethral sphincter can theoretically be treated by injections of botulinum A toxin into the external urethral sphincter. This randomized, double-blind, placebo-controlled trial was designed to determine the clinical efficacy of onabotulinumtoxinA urethral sphincter injections in patients with dysfunctional voiding or detrusor underactivity. Patients with medically refractory dysfunctional voiding (n = 31) or detrusor underactivity (n = 31) were randomly allocated in a 2:1 ratio to receive either onabotulinumtoxinA (100 U) (n = 38) or placebo (normal saline) (n = 24)...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847918/does-uroflowmetry-parameter-facilitate-discrimination-between-detrusor-underactivity-and-bladder-outlet-obstruction
#6
Kwon Soo Lee, Phil Hyun Song, Young Hwii Ko
PURPOSE: Though urodynamic study (UDS) is the current established standard to distinguish between detrusor underactivity (DU) and bladder outlet obstruction (BOO), concerns of patient discomfort and potential complications of catheterization deters its use. We inspected clinical variables to discriminate between DU and BOO in uroflowmetry, which can be more easily performed in clinical practice. MATERIALS AND METHODS: Total 240 men who both underwent UDS and uroflowmetry were reviewed...
November 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27798943/effects-of-distigmine-on-electrical-field-stimulation-induced-contraction-of-mouse-urinary-bladder-smooth-muscles
#7
Keisuke Obara, Yurina Kobayashi, Daisuke Chino, Yoshio Tanaka
Distigmine bromide (distigmine), a reversible carbamate cholinesterase inhibitor, is used in Japan for treating detrusor underactivity, myasthenia gravis, and glaucoma. Although there is clinical evidence about the effectiveness of distigmine in the treatment of detrusor underactivity, mechanisms by which distigmine restores impaired urinary bladder smooth muscle (UBSM) contractility have not been fully investigated. The aims of this study were to investigate the potentiating effects of distigmine on UBSM contractions in response to parasympathetic nerve stimulation induced by electrical field stimulation (EFS) in mice...
November 1, 2016: Pharmacology
https://www.readbyqxmd.com/read/27751474/re-unravelling-detrusor-underactivity-development-of-a-bladder-outlet-resistance-bladder-contractility-nomogram-for-adult-male-patients-with-lower-urinary-tract-symptoms
#8
https://www.readbyqxmd.com/read/27751468/re-factors-impacting-bladder-underactivity-and-clinical-implications
#9
Alan J Wein
No abstract text is available yet for this article.
November 2016: Journal of Urology
https://www.readbyqxmd.com/read/27751467/re-detrusor-underactivity-and-the-underactive-bladder-symptoms-function-cause-what-do-we-mean-ici-rs-think-tank-2014
#10
Alan J Wein
No abstract text is available yet for this article.
November 2016: Journal of Urology
https://www.readbyqxmd.com/read/27687821/systematic-review-of-the-performance-of-noninvasive-tests-in-diagnosing-bladder-outlet-obstruction-in-men-with-lower-urinary-tract-symptoms
#11
REVIEW
Sachin Malde, Arjun K Nambiar, Roland Umbach, Thomas B Lam, Thorsten Bach, Alexander Bachmann, Marcus J Drake, Mauro Gacci, Christian Gratzke, Stephan Madersbacher, Charalampos Mamoulakis, Kari A O Tikkinen, Stavros Gravas
CONTEXT: Several noninvasive tests have been developed for diagnosing bladder outlet obstruction (BOO) in men to avoid the burden and morbidity associated with invasive urodynamics. The diagnostic accuracy of these tests, however, remains uncertain. OBJECTIVE: To systematically review available evidence regarding the diagnostic accuracy of noninvasive tests in diagnosing BOO in men with lower urinary tract symptoms (LUTS) using a pressure-flow study as the reference standard...
March 2017: European Urology
https://www.readbyqxmd.com/read/27547465/the-challenges-in-the-diagnosis-of-detrusor-underactivity-in-clinical-practice-a-mini-review
#12
REVIEW
Ahmed Ahmed, Bilal Farhan, Simone Vernez, Gamal M Ghoniem
OBJECTIVE: To review the current definitions, terminology, epidemiology and aetiology of detrusor underactivity (DU), with specific attention to the diagnostic criteria in use. In addition, we address the relation and the overlap between DU and bladder outlet obstruction (BOO). In this mini-review, we hope to help identify DU patients and facilitate structured clinical evaluation and research. METHODS: We searched the English literature using ScienceDirect and PubMed for relevant articles...
September 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27473156/a-cross-sectional-study-in-the-usa-of-the-epidemiology-and-quality-of-life-of-underactive-bladder-symptoms
#13
Kassem Faraj, Florence Doo, Judy Boura, Andrew Vereecke, Michael B Chancellor
PURPOSE: To assess the prevalence, awareness, and quality of life (QOL) impact of symptoms suggestive of underactive bladder (UAB) in the USA. METHODS: A thirteen-item paper survey was mailed to 25,000 individuals 60 years or older living in the USA. It aimed to collect information relating to demographics, familiarity with UAB, patient urinary symptoms, and QOL concerns. RESULTS: Nine hundred and seventy-seven survey participants were stratified into four groups based on the number of UAB symptoms (straining, retention, and difficulty emptying) present: zero, one, two, and three...
November 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27460338/phenotyping-women-with-detrusor-underactivity-by-presumed-etiology-is-it-plausible
#14
Elizabeth T Brown, Joshua A Cohn, Melissa R Kaufman, Roger R Dmochowski, William S Reynolds
AIMS: Underactive bladder (UAB) is a symptom complex with poorly characterized causation. The aim of this study was to determine if clinical and UDS parameters differed between categories of presumed detrusor underactivity (DU) etiologies. METHODS: A retrospective review was performed at a single institution from 2011 to 2015 to identify patients with symptoms of UAB. Patients were excluded if they were male, had anti-incontinence, or pelvic organ prolapse (POP) surgery within 1 year, or the UDS did not demonstrate DU as defined within...
July 26, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27450935/long-term-efficacy-of-holmium-laser-enucleation-of-the-prostate-in-patients-with-detrusor-underactivity-or-acontractility
#15
Derek J Lomas, Amy E Krambeck
OBJECTIVE: To evaluate long-term outcomes for men with benign prostatic obstruction (BPO) and concurrent detrusor underactivity (DUA) or acontractility following holmium laser enucleation of the prostate (HoLEP). METHODS: A retrospective chart review was performed on all patients with BPO and urodynamic evidence of DUA or acontractility secondary to a nonneurogenic etiology that underwent HoLEP at our institution over a 4-year period. Patients were included if they had at least 24 months of follow-up...
November 2016: Urology
https://www.readbyqxmd.com/read/27447991/ultrasound-detrusor-wall-thickness-measurement-in-combination-with-bladder-capacity-can-safely-detect-detrusor-underactivity-in-adult-men
#16
Kevin L J Rademakers, Gommert A van Koeveringe, Matthias Oelke
PURPOSE: Detrusor underactivity (DU) has lately gained increasing interest because this bladder condition is an important cause of post-void residual urine and lower urinary tract symptoms (LUTS) in adult men. Until now, DU can only be diagnosed by pressure-flow measurement. Therefore, the aim of this study was to search for noninvasive tests which can safely predict DU in adult men. METHODS: Unselected, treatment-naïve male patients aged ≥40 years with uncomplicated, non-neurogenic LUTS were prospectively evaluated...
July 22, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27444952/the-potential-role-of-unregulated-autonomous-bladder-micromotions-in-urinary-storage-and-voiding-dysfunction-overactive-bladder-and-detrusor-underactivity
#17
REVIEW
Marcus J Drake, Anthony Kanai, Dominika A Bijos, Youko Ikeda, Irina Zabbarova, Bahareh Vahabi, Christopher H Fry
The isolated bladder shows autonomous micromotions, which increase with bladder distension, generate sensory nerve activity, and are altered in models of urinary dysfunction. Intravesical pressure resulting from autonomous activity putatively reflects three key variables; the extent of micromotion initiation, distances over which micromotions propagate, and overall bladder tone. In vivo, these variables are subordinate to the efferent drive of the central nervous system. In the micturition cycle storage phase, efferent inhibition keeps autonomous activity generally at a low level, where it may signal 'state of fullness', whilst maintaining compliance...
January 2017: BJU International
https://www.readbyqxmd.com/read/27437534/progressive-changes-in-detrusor-function-and-micturition-patterns-with-chroinc-bladder-ischemia
#18
Zuohui Zhao, Roya Azad, Jing-Hua Yang, Mike B Siroky, Kazem M Azadzoi
PURPOSE: Lower urinary tract symptoms (LUTS) are bothersome constellation of voiding symptoms in men and women as they age. Multiple factors and comorbidities are attributed to this problem but underlying mechanisms of nonobstructive nonneurogenic detrusor overactivity, detrusor underactivity and LUTS remain largely unknown. Our goal was to characterize detrusor function and voiding patterns in relation to muscarinic receptors expression, nerve fiber density, and neural ultrastructure in chronic bladder ischemia...
July 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27436428/urothelial-barrier-deficits-suburothelial-inflammation-and-altered-sensory-protein-expression-in-detrusor-underactivity
#19
Yuan-Hong Jiang, Hann-Chorng Kuo
PURPOSE: The pathophysiology of detrusor underactivity remains unclear and impaired bladder afferent function is considered one of the important etiologies. We investigated urothelial barrier deficits, suburothelial inflammation and sensory proteins expressed in the bladder mucosa of patients with detrusor underactivity. MATERIALS AND METHODS: Bladder mucosa biopsies were performed in 34 patients with videourodynamic proven detrusor underactivity as the study group and in 10 women with stress urinary incontinence as controls...
January 2017: Journal of Urology
https://www.readbyqxmd.com/read/27366877/role-of-bladder-dysfunction-in-men-with-lower-urinary-tract-symptoms-refractory-to-alpha-blocker-therapy-a-video-urodynamic-analysis
#20
Yuan-Hong Jiang, Chun-Hou Liao, Hann-Chorng Kuo
OBJECTIVES: Lower urinary tract symptoms (LUTS) in men result from a complex interplay of pathophysiology, including bladder and bladder outlet dysfunction. This study retrospectively analyzed bladder dysfunction in men with LUTS based on the results of video-urodynamic studies (VUDS). METHODS: Male patients (aged ≥40 years), with LUTS and an International Prostate Symptom Score of 8 or more, who were refractory to alpha-blocker treatment were retrospectively recruited and evaluated with VUDS and total prostate volume (TPV)...
July 1, 2016: Lower Urinary Tract Symptoms
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