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https://www.readbyqxmd.com/read/27926516/frequent-silencing-of-the-candidate-tumor-suppressor-trim58-by-promoter-methylation-in-early-stage-lung-adenocarcinoma
#1
Koichiro Kajiura, Kiyoshi Masuda, Takuya Naruto, Tomohiro Kohmoto, Miki Watabnabe, Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Akira Tangoku, Issei Imoto
In this study, we aimed to identify novel drivers that would be epigenetically altered through aberrant methylation in early-stage lung adenocarcinoma (LADC), regardless of the presence or absence of tobacco smoking-induced epigenetic field defects. Through genome-wide screening for aberrantly methylated CpG islands (CGIs) in 12 clinically uniform, stage-I LADC cases affecting six non-smokers and six smokers, we identified candidate tumor-suppressor genes (TSGs) inactivated by hypermethylation. Through systematic expression analyses of those candidates in panels of additional tumor samples and cell lines treated or not treated with 5-aza-deoxycitidine followed by validation analyses of cancer-specific silencing by CGI hypermethylation using a public database, we identified TRIM58 as the most prominent candidate for TSG...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27923864/outcomes-of-the-smoker-s-health-project-a-pragmatic-comparative-effectiveness-trial-of-tobacco-dependence-interventions-based-on-self-determination-theory
#2
Geoffrey C Williams, Christopher P Niemiec, Heather Patrick, Richard M Ryan, Edward L Deci
A pragmatic comparative effectiveness trial examined whether extending the duration of a cost-effective, intensive tobacco-dependence intervention designed to support autonomy will facilitate long-term tobacco abstinence. Participants were randomly assigned to one of three tobacco-dependence interventions based on self-determination theory, namely, Intensive Treatment (IT; six contacts over 6 months), Extended Need Support (ENS; eight contacts over 12 months) and Harm Reduction (HR; eight contacts over 12 months with medication use if willing to reduce cigarette use by half)...
December 2016: Health Education Research
https://www.readbyqxmd.com/read/27920412/leptin-and-calorie-intake-among-different-nicotine-dependent-groups
#3
Muhammad Zulhusni Suhaimi, Zulkefli Sanip, Hamid Jan Jan, Harmy Mohamed Yusoff
BACKGROUND: Exposure to nicotine via tobacco smoking may influence leptin release and decrease food intake among smokers. However, the effect of nicotine exposure on leptin and food intake among different nicotine dependent groups is unclear. OBJECTIVE: We aimed to measure leptin and calorie intake among different nicotine dependent groups. DESIGN: Cross-sectional study. SETTING: Research department in school of medical sciences...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27918997/the-curvilinear-effects-of-sexual-orientation-on-young-adult-substance-use
#4
Jamie E Parnes, Ryan L Rahm-Knigge, Bradley T Conner
Alcohol, tobacco, and marijuana are commonly used by adolescents and linked with harmful health-related outcomes (e.g. injury, dependence). Moreover, heavy episodic (binge) drinking predicts more severe consequences. When examined by sexual orientation, highest rates of substance use have been found among bisexual individuals, with lower use at either end of the spectrum. When examined also by sex, this curvilinear trend is maintained among women but not men. These substance use patterns were identified using group differences (i...
November 18, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27917180/role-of-the-gacs-sensor-kinase-in-the-regulation-of-volatile-production-by-plant-growth-promoting-pseudomonas-fluorescens-sbw25
#5
Xu Cheng, Viviane Cordovez, Desalegn W Etalo, Menno van der Voort, Jos M Raaijmakers
In plant-associated Pseudomonas species, the production of several secondary metabolites and exoenzymes is regulated by the GacS/GacA two-component regulatory system (the Gac-system). Here, we investigated if a mutation in the GacS sensor kinase affects the production of volatile organic compounds (VOCs) in P. fluorescens SBW25 (Pf.SBW25) and how this impacts on VOCs-mediated growth promotion and induced systemic resistance of Arabidopsis and tobacco. A total of 205 VOCs were detected by Gas Chromatography Mass Spectrometry for Pf...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27914771/overview-of-electronic-nicotine-delivery-systems-a-systematic-review
#6
REVIEW
Allison M Glasser, Lauren Collins, Jennifer L Pearson, Haneen Abudayyeh, Raymond S Niaura, David B Abrams, Andrea C Villanti
CONTEXT: Rapid developments in e-cigarettes, or electronic nicotine delivery systems (ENDS), and the evolution of the overall tobacco product marketplace warrant frequent evaluation of the published literature. The purpose of this article is to report updated findings from a comprehensive review of the published scientific literature on ENDS. EVIDENCE ACQUISITION: The authors conducted a systematic review of published empirical research literature on ENDS through May 31, 2016, using a detailed search strategy in the PubMed electronic database, expert review, and additional targeted searches...
November 30, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27913438/quantifying-the-dynamics-of-field-cancerization-in-tobacco-related-head-and-neck-cancer-a-multiscale-modeling-approach
#7
Marc D Ryser, Walter T Lee, Neal E Ready, Kevin Z Leder, Jasmine Foo
High rates of local recurrence in tobacco-related head and neck squamous cell carcinoma (HNSCC) are commonly attributed to unresected fields of precancerous tissue. Because they are not easily detectable at the time of surgery without additional biopsies, there is a need for noninvasive methods to predict the extent and dynamics of these fields. Here, we developed a spatial stochastic model of tobacco-related HNSCC at the tissue level and calibrated the model using a Bayesian framework and population-level incidence data from the Surveillance, Epidemiology, and End Results (SEER) registry...
October 20, 2016: Cancer Research
https://www.readbyqxmd.com/read/27907086/stcdpk3-phosphorylates-in-vitro-two-transcription-factors-involved-in-ga-and-aba-signaling-in-potato-strsg1-and-stabf1
#8
Carolina Grandellis, Elisa Fantino, María Noelia Muñiz García, Magalí Graciela Bialer, Franco Santin, Daniela Andrea Capiati, Rita María Ulloa
Calcium-dependent protein kinases, CDPKs, decode calcium (Ca2+) transients and initiate downstream responses in plants. In order to understand how CDPKs affect plant physiology, their specific target proteins must be identified. In tobacco, the bZIP transcription factor Repression of Shoot Growth (NtRSG) that modulates gibberellin (GA) content is a specific target of NtCDPK1. StCDPK3 from potato is homologous (88% identical) to NtCDPK1 even in its N-terminal variable domain. In this work, we observe that NtRSG is also phosphorylated by StCDPK3...
2016: PloS One
https://www.readbyqxmd.com/read/27905949/burden-of-cumulative-risk-factors-associated-with-non-communicable-diseases-among-adults-in-uganda-evidence-from-a-national-baseline-survey
#9
Ronald Wesonga, David Guwatudde, Silver K Bahendeka, Gerald Mutungi, Fabian Nabugoomu, James Muwonge
BACKGROUND: Modification of known risk factors has been the most tested strategy for dealing with non-communicable diseases (NCDs). The cumulative number of NCD risk factors exhibited by an individual depicts a disease burden. However, understanding the risk factors associated with increased NCD burden has been constrained by scarcity of nationally representative data, especially in the developing countries and not well explored in the developed countries as well. METHODS: Assessment of key risk factors for NCDs using population data drawn from 3987 participants in a nationally representative baseline survey in Uganda was made...
December 1, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27905929/smoking-cessation-programmes-using-traditional-medicine-in-korea
#10
Soobin Jang, Yu Lee Park, Ju Ah Lee, Kyeong Han Kim, Eun-Kyoung Lee, Seung-Ho Sun, Yong-Cheol Shin, Seong-Gyu Ko, Sunju Park
BACKGROUND: There are growing interests in using various methods including traditional and complementary medicines (T&CM) for tobacco control. The study aimed to introduce how traditional Korean medicine (TKM) applied to smoking cessation programmes in Korea and to show the detail information of each programme for designing other smoke cessation programmes. METHODS: Reports of the smoke cessation programmes in Korea were searched on March 10th, 2016, from the webpages of the related agencies and the databases: the Ministry of Health and Welfare, the Korea Health Foundation, the Association of Korean Medicine, PubMed, Google scholar, the RISS, the KISS, the NDSL, and the OASIS...
December 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27905641/-factors-associated-with-success-of-a-smoking-cessation-program
#11
Pedro Peña, Mónica Zagolin, Mónica Acuña, Sandra Navarrete, Pilar Bustamante, Andrea Canals
BACKGROUND: Smoking cessation therapies include counseling, psychological management and pharmacological therapy. Varenicline is the most effective and safe medication available. AIM: To study risk factors for the failure of pharmacological smoking cessation therapy with varenicline. PATIENTS AND METHODS: Retrospective analysis of 281 patients aged 45 ± 11 years (65% males) with a mean consumption of 31 ± 22 packs/year. They completed a smoking cessation program comprising psychological support and use of varenicline in a private clinic...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27903957/medicalisation-smoking-and-e-cigarettes-evidence-and-implications
#12
Kylie Morphett, Adrian Carter, Wayne Hall, Coral Gartner
There is debate in the tobacco control literature about the value of a medical model in reducing smoking-related harm. The variety of medical treatments for smoking cessation has increased, health professionals are encouraged to use them to assist smoking cessation and tobacco dependence is being described as a 'chronic disease'. Some critics suggest that the medicalisation of smoking undermines the tobacco industry's responsibility for the harms of smoking. Others worry that it will lead smokers to deny personal responsibility for cessation, create beliefs in 'magic bullets' for smoking cessation, or erode smokers' confidence in their ability to quit...
November 30, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27901585/a-review-of-positron-emission-tomography-studies-exploring-the-dopaminergic-system-in-substance-use-with-a-focus-on-tobacco-as-a-co-variate
#13
Thulasi Thiruchselvam, Saima Malik, Bernard Le Foll
With the evolving sensitivity of positron emission tomography (PET) and the emergence of novel radiotracers, greater insight has been gained into the dopaminergic system as it relates to substance use. In this review, we summarize PET investigations from the last ten years that explore the dopaminergic system in tobacco, alcohol, stimulant, opiates, and cannabis addiction. In light of the prevalence of substance co-use, this review will also explore the effect of tobacco and other substance abuse co-morbidity on the dopaminergic system across study samples in the reviewed literature...
November 30, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27900650/smoking-cessation-and-electronic-cigarettes-in-community-mental-health-centers-patient-and-provider-perspectives
#14
Li-Shiun Chen, Timothy Baker, Ross C Brownson, Robert M Carney, Douglas Jorenby, Sarah Hartz, Nina Smock, Mark Johnson, Douglas Ziedonis, Laura J Bierut
Little is known about patients' electronic cigarette use, interest in and use of smoking cessation treatments, and providers' attitude towards such treatment. We assessed patients (N = 231) and providers (45 psychiatrists, 97 case workers) in four Community Mental Health Centers. Interestingly, 50% of smokers reported interest in using electronic cigarettes to quit smoking, and 22% reported current use. While 82% of smokers reported wanting to quit or reduce smoking, 91% of psychiatrists and 84% of case workers reported that patients were not interested in quitting as the lead barrier, limiting the provision of cessation interventions...
November 30, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27891376/smokeless-tobacco-and-stroke-a-clinico-epidemiological-follow-up-study-in-a-tertiary-care-hospital
#15
Subhransu Sekhar Jena, Shobhitendu Kabi, Baikuntha Nath Panda, B C Kameswari, Payal, Ishwar Chandra Behera, Subrat Kumar Tripathy, Seemanchana Mahanta
INTRODUCTION: Among the modifiable risk factors for stroke, tobacco smoking is well recognized. In some studies the use of Smokeless Tobacco (ST) has also been contributed as a risk factor for ischemic stroke. Use of ST is very common in South-East Asia. The form of ST varies according to the geographical and cultural variation. AIM: To study the various clinical symptoms and radiological findings of stroke due to different types of ST. MATERIALS AND METHODS: This was a prospective hospital based study carried out over a period of 2 years...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890648/bupropion-sustained-release-for-pregnant-smokers-a%C3%A2-randomized-placebo-controlled-trial
#16
Tatiana N Nanovskaya, Cheryl Oncken, Valentina M Fokina, Richard S Feinn, Shannon M Clark, Holly West, Sunil K Jain, Mahmoud S Ahmed, Gary D V Hankins
BACKGROUND: Bupropion is used to treat depression during pregnancy. However, its usefulness as a smoking cessation aid for pregnant women is not fully known. OBJECTIVE: The objective of the study was to evaluate the preliminary efficacy of bupropion sustained release for smoking cessation during pregnancy. STUDY DESIGN: We conducted a randomized, prospective, double-blind, placebo-controlled, pilot trial. Pregnant women who smoked daily received individualized behavior counseling and were randomly assigned to a 12 week, twice-a-day treatment with 150 mg bupropion sustained release or placebo...
November 25, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27888969/smoking-behaviors-and-medical-co-morbidities-in-patients-with-mental-illnesses
#17
Peggy El-Mallakh, Danielle McPeak, Milan Khara, Chizimuzo T Okoli
Correlations among smoking behaviors and co-morbid medical illnesses were examined among 982 smokers with mental illnesses enrolled in a smoking cessation program within Mental Health and Addictions Services in Vancouver, Canada. Significant correlates among individuals with psychotic disorders included associations between a history of emphysema/chronic obstructive pulmonary (COPD) disease and cigarettes smoked per day (r's=.35, p≤.01), Confidence in quitting (r's=-.33, p≤.01), and nicotine dependence (r's=...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27878808/interventions-for-tobacco-use-cessation-in-people-in-treatment-for-or-recovery-from-substance-use-disorders
#18
REVIEW
Dorie Apollonio, Rose Philipps, Lisa Bero
BACKGROUND: Smoking rates in people with alcohol and other drug dependencies are two to four times those of the general population. Concurrent treatment of tobacco dependence has been limited due to concern that these interventions are not successful in this population or that recovery from other addictions could be compromised if tobacco cessation was combined with other drug dependency treatment. OBJECTIVES: To evaluate whether interventions for tobacco cessation are associated with tobacco abstinence for people in concurrent treatment for or in recovery from alcohol and other drug dependence...
November 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27878174/dynamic-dna-controlled-stop-and-go-assembly-of-well-defined-protein-domains-on-rna-scaffolded-tmv-like-nanotubes
#19
Angela Schneider, Fabian J Eber, Nana L Wenz, Klara Altintoprak, Holger Jeske, Sabine Eiben, Christina Wege
A DNA-based approach allows external control over the self-assembly process of tobacco mosaic virus (TMV)-like ribonucleoprotein nanotubes: their growth from viral coat protein (CP) subunits on five distinct RNA scaffolds containing the TMV origin of assembly (OAs) could be temporarily blocked by a stopper DNA oligomer hybridized downstream (3') of the OAs. At two upstream (5') sites tested, simple hybridization was not sufficient for stable stalling, which correlates with previous findings on a non-symmetric assembly of TMV...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27871728/the-chrna5-a3-b4-gene-cluster-and-smoking-from-discovery-to-therapeutics
#20
REVIEW
Glenda Lassi, Amy E Taylor, Nicholas J Timpson, Paul J Kenny, Robert J Mather, Tim Eisen, Marcus R Munafò
Genome-wide association studies (GWASs) have identified associations between the CHRNA5-CHRNA3-CHRNB4 gene cluster and smoking heaviness and nicotine dependence. Studies in rodents have described the anatomical localisation and function of the nicotinic acetylcholine receptors (nAChRs) formed by the subunits encoded by this gene cluster. Further investigations that complemented these studies highlighted the variability of individuals' smoking behaviours and their ability to adjust nicotine intake. GWASs of smoking-related health outcomes have also identified this signal in the CHRNA5-CHRNA3-CHRNB4 gene cluster...
November 18, 2016: Trends in Neurosciences
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