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https://www.readbyqxmd.com/read/29244639/oscillatory-mechanisms-of-response-conflict-elicited-by-color-and-motion-direction-an-individual-differences-approach
#1
Marlies E Vissers, K Richard Ridderinkhof, Michael X Cohen, Heleen A Slagter
Goal-directed behavior requires control over automatic behavior, for example, when goal-irrelevant information from the environment captures an inappropriate response and conflicts with the correct, goal-relevant action. Neural oscillations in the theta band (∼6 Hz) measured at midfrontal electrodes are thought to form an important substrate of the detection and subsequent resolution of response conflict. Here, we examined the extent to which response conflict and associated theta-band activity depend on the visual stimulus feature dimension that triggers the conflict...
December 15, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29244522/pulmonary-vasodilator-therapy-in-shock-associated-cardiac-arrest
#2
Ryan W Morgan, Robert M Sutton, Michael Karlsson, Andrew J Lautz, Constantine D Mavroudis, William P Landis, Yuxi Lin, Sejin Jeong, Nancy Craig, Vinay M Nadkarni, Todd J Kilbaugh, Robert A Berg
RATIONALE: Many in-hospital cardiac arrests are precipitated by hypotension, often associated with systemic inflammation. These patients are less likely to be successfully resuscitated and novel approaches to their treatment are needed. OBJECTIVES: To determine if the addition of inhaled nitric oxide (iNO) to hemodynamic-directed cardiopulmonary resuscitation (HD-CPR) would improve short-term survival from cardiac arrest associated with shock and systemic inflammation...
December 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29243435/-new-qualities-control-strategy-of-scutellaria-baicalensis-by-isothermal-titration-calorimetry
#3
Tong Li, Hao Zhang, Xue-Hao Tian, Hui Wang, Guang-Xi Ren, Wen-Guang Jing, Bing Xu, Fu-Hao Chu, Peng-Long Wang, Hai-Min Lei
It has been focused on that there will be precipitates when decoction of Scutellariat Radix mixed with Coptidis Rhizoma. Precipitation was derived from interaction between acidic and basic compounds. This study was based on the interaction between active ingredients after compatibility, strived to explore whether it was feasible to judge the qualities of different Scutellariat Radix by isothermal titration calorimetry (ITC), build a new method established to characterize the qualities of traditional Chinese medicine by taking a series of active ingredients as index...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29242809/effect-of-levodopa-carbidopa-intestinal-gel-on-non-motor-symptoms-in-patients-with-advanced-parkinson-s-disease
#4
David G Standaert, Ramon L Rodriguez, John T Slevin, Michael Lobatz, Susan Eaton, Krai Chatamra, Maurizio F Facheris, Coleen Hall, Kavita Sail, Yash J Jalundhwala, Janet Benesh
Background: Levodopa-carbidopa intestinal gel (LCIG; carbidopa-levodopa enteral suspension in the United States), delivered via percutaneous gastrojejunostomy (PEG-J) and titrated in the inpatient setting, is an established treatment option for advanced Parkinson's disease (PD) patients with motor fluctuations. However, long-term prospective data on the efficacy of LCIG on non-motor symptoms and the safety of outpatient titration are limited. Methods: In this 60-week, open-label phase 3b study, LCIG titration was initiated in an outpatient setting following PEG-J placement in PD patients...
November 2017: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/29242650/infusion-dose-requirement-of-rocuronium-in-patients-on-phenytoin-therapy-a-prospective-comparative-study
#5
Veena Sheshadri, Arathi Radhakrishnan, Kusuma Halemani, Venkatesh H Keshavan
Background and Aims: Patients with intracranial tumour are usually on anticonvulsants. Patients on phenytoin therapy demonstrate rapid metabolism of nondepolarising muscle relaxants secondary to enzyme induction. Infusion dose requirement of rocuronium in such patients has been sparingly studied. We studied the continuous infusion dose requirement of rocuronium bromide in patients on phenytoin therapy and its correlation with serum levels of phenytoin. Methods: Seventy-five patients scheduled for supratentorial tumour surgery were included in the study...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29241317/optimization-of-soymilk-mango-nectar-and-sucrose-solution-mixes-for-better-quality-of-soymilk-based-beverage
#6
Rahel Getu, Yetenayet B Tola, Satheesh Neela
BACKGROUND: Soy milk-based beverages play an important role as a healthy food alternative for human consumption. However, the ‘beany’ flavor and chalky mouth feel of soy milk often makes it unpalatable to consumers. The objective of the present study is to optimize a blend of soy milk, mango nectar and sucrose solution for the best quality soy milk-based beverage. METHODS: This study was designed to develop a soy milk blended beverage, with mango nectar and sucrose solutions, with the best physicochemical and sensory properties...
October 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29241218/analysis-of-the-cariogenic-potential-of-various-almond-milk-beverages-using-a-streptococcus-mutans-biofilm-model-in-vitro
#7
Janelle Lee, Janice A Townsend, Tatyana Thompson, Thomas Garitty, Arpan De, Qingzhao Yu, Brian M Peters, Zezhang T Wen
To evaluate the cariogenic properties of almond milk beverages, 6 almond milks, along with soy and whole bovine milk, were analyzed for their abilities to support Streptococcus mutans biofilm formation and acid production, and their capacity to buffer changes in pH. Biofilm formation by S. mutans was analyzed using an in vitro 96-well plate model and measured by crystal violet staining. Acid production by S. mutans was evaluated by a colorimetric L-lactate assay and pH measurement of bacterial cultures. Buffering capacity was assessed by a pH titration assay...
December 15, 2017: Caries Research
https://www.readbyqxmd.com/read/29240650/oxytocin-use-in-labor-legal-implications
#8
Susan Drummond
Oxytocin is one of the most commonly used medications in obstetrics and has been associated with claims of negligence in cases of adverse outcomes. Errors involving intravenous oxytocin administration for induction or augmentation of labor are most commonly dose related and include failure to avoid or treat tachysystole or failure to asses or treat a fetal heart rate pattern indicative of disruption in oxygenation. Clinicians should be knowledgeable regarding pharmacokinetics of oxytocin and the effect of uterine contractions on fetal oxygenation as well as safe titration of oxytocin to achieve the desired effect while minimizing harm...
December 13, 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29240642/body-mass-s-impact-on-response-to-fixed-dose-vasopressin-in-patients-with-septic-shock
#9
Heather Torbic, Gretchen L Sacha, Seth R Bauer, Simon W Lam
INTRODUCTION: The effect of patient weight and body mass index (BMI) on hemodynamic response to vasoactive medications is not fully understood. In titratable vasopressors, this effect is less likely a concern due to the ability to titrate dose to response, however, with the use of fixed-dose vasopressin, patient weight and BMI may impact response. METHODS: This was a single center, retrospective cohort of patients who received fixed-dose vasopressin for septic shock for ≥6 hours with concomitant catecholamines in the medical, surgical, or neurosciences intensive care unit (ICU) at a tertiary care center...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240404/conservation-of-specificity-in-two-low-specificity-proteins
#10
Lucas C Wheeler, Jeremy A Anderson, Anneliese J Morrison, Caitlyn E Wong, Michael Harms
Many regulatory proteins bind peptide regions of target proteins and modulate their activity. Such regulatory proteins can often interact with highly diverse target peptides. In many instances, it is not known if the peptide-binding interface discriminates targets in a biological context, or whether biological specificity is achieved exclusively through external factors such as subcellular localization. We used an evolutionary biochemical approach to distinguish these possibilities for two such low-specificity proteins: S100A5 and S100A6...
December 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/29239979/monitoring-haloperidol-plasma-concentration-and-associated-adverse-events-in-critically-ill-children-with-delirium-first-results-of-a-clinical-protocol-aimed-to-monitor-efficacy-and-safety
#11
Valerie D Slooff, Desley K van den Dungen, Babette S van Beusekom, Naomi Jessurun, Erwin Ista, Dick Tibboel, Saskia N de Wildt
OBJECTIVES: As delirium in critically ill children is increasingly recognized, more children are treated with the antipsychotic drug haloperidol, while current dosing guidelines are lacking solid evidence and appear to be associated with a high risk of adverse events. We aim to report on the safety and efficacy of a recently implemented clinical dose-titration protocol with active monitoring of adverse events. DESIGN: From July 2014 until June 2015, when a potential delirium was identified by regular delirium scores and confirmed by a child psychiatrist, haloperidol was prescribed according to the Dutch Pediatric Formulary...
December 12, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29239774/the-clinical-use-of-mechanical-insufflation-exsufflation-in-children-with-neuromuscular-disorders-in-europe
#12
REVIEW
Brit Hov, Tiina Andersen, Vegard Hovland, Michel Toussaint
Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in studies vary. Our objective was to assess the actual MI-E settings being used in current clinical treatment of children with NMDs and a survey was sent in July 2016 to European expertise centers. Ten centers from seven countries gave information on MI-E settings for 240 children aged 4 months to 17...
November 3, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29239606/biosurfactant-protein-interaction-in%C3%AF-uences-of-mannosylerythritol-lipids-a-on-%C3%AE-glucosidase
#13
Linlin Fan, Pu-Jun Xie, Ying Wang, Zisu Huang, Jianzhong Zhou
In this work, the influences of a biosurfactant, mannosylerythritol lipids-A (MEL-A) towards β-glucosidase activity and their molecular interactions were studied by using differential scanning calorimetry (DSC), circular dichroism spectroscopy (CD), isothermal titration calorimetry (ITC) and docking simulation. The enzyme inhibition kinetics data showed that MEL-A at a low concentration (< CMC, 20.0±5.0 μM) enhanced β-glucosidase activity, whereas it inhibited the enzyme activity at higher concentrations more than 20...
December 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29239515/rationale-and-design-of-transition-a-randomized-trial-of-pre-discharge-vs-post-discharge-initiation-of-sacubitril-valsartan
#14
Domingo Pascual-Figal, Rolf Wachter, Michele Senni, Jan Belohlavek, Adele Noè, David Carr, Dmytro Butylin
AIMS: The prognosis after hospitalization for acute decompensated heart failure (ADHF) remains poor, especially <30 days post-discharge. Evidence-based medications with prognostic impact administered at discharge improve survival and hospital readmission, but robust studies comparing pre-discharge with post-discharge initiation are rare. The PARADIGM-HF trial established sacubitril/valsartan as a new evidence-based therapy in patients with heart failure (HF) and reduced left ventricular ejection fraction (<40%) (rEF)...
December 14, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29239148/effects-of-closed-loop-intravenous-anesthesia-guided-by-the-bispectral-index-in-adult-patients-on-emergence-delirium-a-randomized-controlled-study
#15
Antonella Cotoia, Lucia Mirabella, Renata Beck, Pompeo Matrella, Valentina Assenzo, Thierry Chazot, Gilda Cinnella, Ngai Liu, Michele Dambrosio
BACKGROUND: Emergence delirium (ED) is an acute change in cognition after general anesthesia (GA) occurring in operative room, recovery room or in postanesthesia care. The automated propofolremifentanil titration by Bispectral index (BIS) (AutoTIVA) avoids period of deep (BIS<40) anesthesia and could potentially decrease the ED. The aim of this study was to evaluate ED in surgical patients under AutoTIVA, manual titration of propofol-remifentanil (ManualTIVA) or volatile BIS-guided GA...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29239081/development-and-validation-of-2d-difference-intensity-analysis-for-chemical-library-screening-by-protein-detected-nmr
#16
John M Egner, Davin R Jensen, Mike D Olp, Nolan W Kennedy, Brian F Volkman, Francis C Peterson, Brian C Smith, R Blake Hill
An academic chemical screening approach was developed and a 352-chemical fragment library screened against 3 different protein targets using 2D protein-detected NMR. The approach was optimized against 2 protein targets with known ligands, CXCL12 and BRD4. Principal component analysis reliably identified compounds that induced NMR crosspeak broadening, but did not unambiguously identify ligands with specific affinity (hits). For improved hit detection, a novel scoring metric - difference intensity analysis (DIA) - was devised that sums all positive and negative intensities from 2D difference spectra...
December 13, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29238782/a-new-heptadentate-picolinate-based-ligand-and-its-corresponding-gd-iii-complex-the-effect-of-pendant-picolinate-versus-acetate-on-complex-properties
#17
Bedika Phukan, Chandan Mukherjee, Raunak Varshney
To attain high relaxivity as well as stability, a new water-soluble, water-coordinated Gd(iii) complex, which was synthesised by reacting equimolar amounts of picolinate-based ligand H4peada and GdCl3·xH2O at pH ∼ 6.5, was examined. The number of inner sphere water molecules (q) in the complex was found to be 1.7 ± 0.1 from luminescence lifetime measurements of its Tb(iii) congener, complex 2. At 1.41 T, 25 °C, and pH = 7.4, the longitudinal relaxivity (r1) value of the complex was found to be 6.08 mM-1 s-1, which remained almost constant in the pH range 4-10...
December 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29238574/role-of-guaifenesin-in-the-management-of-chronic-bronchitis-and-upper-respiratory-tract-infections
#18
REVIEW
Helmut H Albrecht, Peter V Dicpinigaitis, Eric P Guenin
Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. It is used for relief of wet cough and chest congestion due to the common cold, and remains the only legally marketed expectorant in the US (per OTC Monograph). An ingredient in numerous over-the-counter (OTC) cough/cold medications, guaifenesin has a secondary indication for use in stable chronic bronchitis (professional indication). Clinical pharmacology and patient studies support the clinical utility of guaifenesin in respiratory conditions where mucus hypersecretion is prevalent: acute upper respiratory tract infections (URTIs), stable chronic bronchitis, and possibly rhinosinusitis...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29238506/comparison-of-the-effect-of-topiramate-versus-gabapentin-on-neuropathic-pain-in-patients-with-polyneuropathy-a-randomized-clinical-trial
#19
Surena Nazarbaghi, Mohammad Reza Amiri-Nikpour, Aynaz Foroughi Eghbal, Rohollah Valizadeh
Background: Neuropathic pain is one of the most common complaints of neurologic clinics. Neuropathic pain is common and important and has inappropriate complications, and despite their importance, there is no effective treatment for them. Objective: Because of the importance of neuropathic pain and safe and effective treatment, in this study, we determined the effect of topiramate versus gabapentin in patients with neuropathic pain. Methods: In this randomized clinical trial, 30 patients with pain attributed to neuropathy who had at least one month of neuropathic pain in one area, were randomized to receive either gabapentin, titrated from 300 mg/day to a maximum of 900 mg/day or topiramate, titrated from 50 mg/day to a maximum of 100 mg/day after a 4-week period in the neurology clinic of Imam Khomeini Hospital of Urmia city, Iran in 2015...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238468/effect-of-fetal-and-adult-bovine-serum-on-pyocyanin-production-in-pseudomonas-aeruginosa-isolated-from-clinical-and-soil-samples
#20
Aylin Moayedi, Jamileh Nowroozi, Abbas Akhavan Sepahy
Objectives: Pyocyanin is a blue-greenish redox-active pigment, produced by Pseudomonas aeruginosa, with a wide range of biological and biotechnological applications. Pyocyanin biosynthesis is regulated by the quorum-sensing (QS) system in which the expression of QS genes and QS-controlled virulence genes may be affected by serum as a complex medium. In the current study, effects of adult bovine serum (ABS) and fetal bovine serum (FBS) on the production of pyocyanin were examined in order to develop it...
December 2017: Iranian Journal of Basic Medical Sciences
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