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https://www.readbyqxmd.com/read/29055066/longitudinal-study-showed-that-the-quality-of-life-of-finnish-adolescents-with-cerebral-palsy-continued-to-be-relatively-good
#1
Sanna Böling, Tarja Varho, Leena Haataja
AIM: This longitudinal study examined what perceptions paediatric patients with cerebral palsy (CP) and their caregivers had of the patient's quality of life (QoL). It examined changing trends as children with CP became adolescents and examined the feasibility of the Finnish version of the CP QOL-Teen questionnaire. METHODS: Carried out in autumn 2015, this study formed part of the multi-centre Finnish national CP project and aimed to validate the CP QOL-Teen questionnaire, which was posted to 54 adolescents and their caregivers...
October 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29054935/familial-history-aggregation-on-acute-appendicitis
#2
Francesc Simó Alari, Israel Gutierrez, Judit Gimenéz Pérez
Appendectomy is the most commonly performed surgical procedure, affecting 1%-8% of the paediatric population, with a total 7% lifetime risk, most likely in adolescents and young adults.A case of familial aggregation was reported in our hospital in a family composed of nine siblings from which six of them (66.6%) had been treated of acute appendicitis, five of them in our centre.Many factors have been described as predisposing to appendicitis. Several studies have highlighted the influence of genes in the evolution of this disease and its severity, demonstrating a relative risk increase by three when family history is present...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054932/improving-paediatric-residents-knowledge-and-perspectives-regarding-the-insulin-pump-using-a-novel-educational-workshop
#3
Shipra Bansal, Albara Marwa, Kannan Kasturi, Sheila Perez-Colon
OBJECTIVES: As a pilot study, we aimed to investigate the knowledge and perceptions of categorical paediatric residents (RES) at our institution regarding insulin pumps (IPs) and the impact following a targeted workshop. METHODS: All RES at our institution in attendance at a routine noon conference participated in a workshop, completing an anonymous survey before and right after the intervention to evaluate knowledge, attitudes and self-reported comfort regarding IPs...
October 20, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29054862/current-evidence-based-recommendations-on-investigating-children-with-global-developmental-delay
#4
REVIEW
Renuka Mithyantha, Rachel Kneen, Emma McCann, Melissa Gladstone
INTRODUCTION: Global developmental delay (GDD) affects 1%-3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are exogenous, genetic (non-metabolic) or genetic (metabolic). Recent advances in biotechnology and genetic testing mean that the investigations available to perform for children under 5 years are increasing and are more sensitive than previously. This change in availability and type of testing necessitates an update in the recommendations for investigating GDD...
November 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29054560/transcultural-adaptation-into-spanish-of-the-induction-compliance-checklist-for-assessing-children-s-behaviour-during-induction-of-anaesthesia
#5
Carmen Jerez-Molina, Juan J Lázaro-Alcay, Ana M Ullán-de la Fuente
OBJECTIVE: Cross-cultural adaptation into Spanish of the Induction Compliance Checklist (ICC) for assessing children's behaviour during induction of anaesthesia. METHOD: A descriptive cross-sectional observational study was conducted on a sample of 81 children aged 2 to 12 years operated in an ambulatory surgery unit of a paediatric hospital in Barcelona. Adaptation by translation-back translation of the tool and analysis of the scale's validity and reliability...
October 17, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/29052340/absence-of-neurocognitive-disadvantage-associated-with-paediatric-hiv-subtype-a-infection-in-children-on-antiretroviral-therapy
#6
Paul Bangirana, Theodore D Ruel, Michael J Boivin, Satish K Pillai, Leila B Giron, Alla Sikorskii, Asish Banik, Jane Achan
INTRODUCTION: Infection with HIV subtype A has been associated with poorer neurocognitive outcomes compared to HIV subtype D in Ugandan children not eligible for antiretroviral therapy (ART). In this study, we sought to determine whether subtype-specific differences are also observed among children receiving ART. MATERIALS AND METHODS: Children were recruited from a clinical trial in which they were randomized to receive either lopinavir (LPV)- or non-nucleoside reverse transcriptase inhibitor (NNRTI)- based ART (NCT00978068)...
October 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29051812/patients-perceptions-on-the-usability-of-the-surepal%C3%A2-self-injection-device-for-omnitrope-%C3%A2-a-questionnaire-based-observational-study-conducted-in-paediatric-patients-in-france
#7
Régis Coutant, Clémentine Dupuis, Patricia Pigeon, Phillipe Rebaud
BACKGROUND: A questionnaire-based survey was conducted to evaluate attitudes towards a reusable self-injection system, SurePal™, among paediatric patients with growth disturbances who were prescribed treatment with somatropin (Omnitrope(®)) as part of routine clinical practice. METHODS: This cross-sectional survey was incorporated into the multinational, multi-centre, noninterventional PAtients TReated with Omnitrope(®) (PATRO) Children study. Questions were mainly focused on five areas: the attractiveness of SurePal™; training received; use of the device; opinion of the low-drug wastage system; experience compared with previous devices used (among pretreated patients)...
September 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29051625/paediatric-rheumatology-dna-methylation-in-oligoarticular-jia
#8
Joanna Collison
No abstract text is available yet for this article.
October 20, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29051328/how-does-sevoflurane-induction-followed-by-a-ketamine-maintenance-infusion-affect-intraocular-pressure-establishment-of-an-anaesthetic-protocol-for-paediatric-glaucoma-examinations-under-anaesthesia
#9
Jessica Gwendoline van der Walt, Francois Roodt, Christopher Tinley
Accurate measurement of intraocular pressure (IOP) is essential in paediatric glaucoma management. Children require serial measurements and examination under anaesthesia (EUA). Most anaesthetic agents reduce IOP, and the ideal time to measure IOP under anaesthesia is questionable. STUDY PURPOSE: To determine the effect of sevoflurane induction, followed by intravenous ketamine infusion on IOP, in children undergoing EUA for glaucoma or suspected glaucoma, and to establish the earliest time point at which reliable, repeatable IOP measurements can be obtained under anaesthesia...
October 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29051195/management-of-paediatric-hernia
#10
Kirk Bowling, Natasha Hart, Phil Cox, Gandrapu Srinivas
No abstract text is available yet for this article.
October 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29050690/how-should-we-treat-the-aya-patient-with-newly-diagnosed-all
#11
REVIEW
Nicolas Boissel
Adolescent and young adult (AYA) patients with acute lymphoblastic leukaemia (ALL) are recognized as a unique population with specific characteristics and needs. In adolescents aged 15-20 years old, the use of full paediatric protocols is supported by many comparative studies of paediatric and adult cooperative groups. In young adults, growing evidence suggests that paediatric-inspired approaches may also improve outcomes and lead to long-term survival rates of almost 70%. In the last decade, better knowledge of ALL oncogenic landscape, age distribution, and minimal residual disease prognostic impact have improved risk stratification...
September 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29050646/worldwide-incidence-and-prevalence-of-inflammatory-bowel-disease-in-the-21st-century-a-systematic-review-of-population-based-studies
#12
Siew C Ng, Hai Yun Shi, Nima Hamidi, Fox E Underwood, Whitney Tang, Eric I Benchimol, Remo Panaccione, Subrata Ghosh, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung, Gilaad G Kaplan
BACKGROUND: Inflammatory bowel disease is a global disease in the 21st century. We aimed to assess the changing incidence and prevalence of inflammatory bowel disease around the world. METHODS: We searched MEDLINE and Embase up to and including Dec 31, 2016, to identify observational, population-based studies reporting the incidence or prevalence of Crohn's disease or ulcerative colitis from 1990 or later. A study was regarded as population-based if it involved all residents within a specific area and the patients were representative of that area...
October 13, 2017: Lancet
https://www.readbyqxmd.com/read/29049836/fluid-accumulation-after-closure-of-atrial-septal-defects-the-role-of-colloid-osmotic-pressure
#13
Marianne Indrebø, Ansgar Berg, Henrik Holmstrøm, Egil Seem, Hans Jørgen Guthe, Helge Wiig, Gunnar Norgård
OBJECTIVES: Following paediatric cardiac surgery with cardiopulmonary bypass (CPB), there is a tendency for fluid accumulation. The colloid osmotic pressure of plasma (COPp) and interstitial fluid (COPi) are determinants of transcapillary fluid exchange but only COPp has been measured in sick children. The aim of this study was to assess the net colloid osmotic pressure gradient in children undergoing atrial septal defect closure. METHODS: Twenty-three patients had interventional and 18 had surgical atrial septal defect closures...
October 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049743/additional-veno-venous-gas-exchange-as-a-problem-solving-strategy-for-an-oxygenator-not-transferring-oxygen-in-paediatric-cardiopulmonary-bypass
#14
Wolfgang Boettcher, Nicodème Sinzobahamvya, Frank Dehmel, Andreas Matschke, Andre Iben, Mi-Young Cho, Mathias Redlin, Joachim Photiadis
OBJECTIVES: Oxygenator failure during cardiopulmonary bypass constitutes a life-threatening event, especially when perfusion is conducted under normothermia. An alternative solution to emergency oxygenator changeover is described. METHODS: A supplementary oxygenator is added in the venous line without interrupting perfusion. De-airing is achieved through the cardiotomy reservoir. Oxygen supply is adapted to ensure physiologic partial oxygen pressure. RESULTS: On 5 occasions in the past 4 years, Capiox Baby FX 05 oxygenator ( n  = 4) and Capiox FX15 ( n  = 1) failed to exchange blood gases after bypass run ranging from 290 min to 563 min...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049673/incidence-and-echocardiographic-predictors-of-early-postoperative-right-ventricular-dysfunction-following-left-ventricular-assist-implantation-in-paediatric-patients
#15
Mathias Redlin, Oliver Miera, Helmut Habazettl, Joachim Photiadis, María Irene Carísimo-Cresta, Mathias Hommel, Benjamin O'Brien, Marian Kukucka
OBJECTIVES: Left ventricular assist device implantation is an established therapy for paediatric patients with end-stage heart failure. Early right ventricular dysfunction (RVD) after implantation still remains a challenge in the postoperative period. This study sought to determine the incidence of RVD and to identify echocardiographic predictors of RVD in paediatric patients, as well describing associated clinical outcome. METHODS: Prospectively collected preoperative echocardiographic, haemodynamic, demographic and biochemical data from 48 patients scheduled for left ventricular assist device implantation were evaluated...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048980/the-2016-lifetime-immunization-schedule-approved-by-the-italian-scientific-societies-a-new-paradigm-to-promote-vaccination-at-all-ages
#16
Paolo Bonanni, Giampietro Chiamenti, Giorgio Conforti, Tommasa Maio, Anna Odone, Rocco Russo, Silvestro Scotti, Carlo Signorelli, Alberto Villani
Medical scientific societies have the core mission of producing, pooling and disseminating solid and updated scientific information. We report the successful experience of the partnership of four national Medical Scientific Societies active in Italy in producing scientific advice on vaccines and vaccination. In particular, i) the Italian Society of Hygiene, Preventive Medicine and Public Health; SitI, ii) the Italian Society of Paediatrics; SIP, ii) the Italian Federation of Family Paediatricians; FIMP, and iv) the Italian Federation of General Medicine FIMMG) have worked together since 2012 to produce shared evidence-based recommendations on vaccination schedules, namely the "Lifetime Immunization Schedule" which introduced for the first time in Italy a life-course approach to vaccination...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048448/exposure-to-individual-and-multiple-carcinogenic-metals-during-paediatric-age-an-experience-from-an-italian-urban-scenario
#17
C Protano, M L Astolfi, S Canepari, R Andreoli, A Mutti, F Valeriani, V Romano Spica, A Antonucci, V Mattei, S Martellucci, M Vitali
BACKGROUND: Exposure to single and multiple carcinogenic metals and/or semimetals represents a major environmental risk factor for public health. In particular, children are more susceptible to environmental pollutants than adults, but specific studies are still limited. The aims of the present study were: 1) to trace the exposure and co-exposure profiles to eight known or suspected carcinogenic metals and semimetals (As, Be, Cd, Co, Cr, Ni, Pb, and Sb); and: 2) to evaluate the influence of some possible interfering/confounding factors on the exposure to these elements during childhood...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048102/high-interpatient-variability-of-treosulfan-exposure-is-associated-with-early-toxicity-in-paediatric-hsct-a-prospective-multicentre-study
#18
M Y Eileen C van der Stoep, Alice Bertaina, Marloes H Ten Brink, Robbert G Bredius, Frans J Smiers, Dominique C M Wanders, Dirk Jan A R Moes, Franco Locatelli, Henk-Jan Guchelaar, Juliëtte Zwaveling, Arjan C Lankester
Treosulfan-based conditioning is increasingly employed in paediatric haematopoietic stem cell transplantation (HSCT). Data on treosulfan pharmacokinetics in children are scarce, and the relationship between treosulfan exposure, toxicity and clinical outcome is unresolved. In this multicentre prospective observational study, we studied treosulfan pharmacokinetics and the drug's relationship with regimen-related toxicity and early clinical outcome in 77 paediatric patients. Treosulfan dose was 30 g/m(2) , administered over 3 consecutive days in infants <1 year old (n = 12) and 42 g/m(2) in children ≥1 year old (n = 65)...
October 19, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29047407/a-web-based-collection-of-genotype-phenotype-associations-in-hereditary-recurrent-fevers-from-the-eurofever-registry
#19
Riccardo Papa, Matteo Doglio, Helen J Lachmann, Seza Ozen, Joost Frenkel, Anna Simon, Bénédicte Neven, Jasmin Kuemmerle-Deschner, Huri Ozgodan, Roberta Caorsi, Silvia Federici, Martina Finetti, Maria Trachana, Jurgen Brunner, Liliana Bezrodnik, Mari Carmen Pinedo Gago, Maria Cristina Maggio, Elena Tsitsami, Wafaa Al Suwairi, Graciela Espada, Anna Shcherbina, Guzide Aksu, Nicolino Ruperto, Alberto Martini, Isabella Ceccherini, Marco Gattorno
BACKGROUND: Hereditary recurrent fevers (HRF) are a group of rare monogenic diseases leading to recurrent inflammatory flares. A large number of variants has been described for the four genes associated with the best known HRF, namely MEFV, NLRP3, MVK, TNFRSF1A. The Infevers database ( http://fmf.igh.cnrs.fr/ISSAID/infevers ) is a large international registry collecting variants reported in these genes. However, no genotype-phenotype associations are provided, but only the clinical phenotype of the first patient(s) described for each mutation...
October 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29046982/ureteroscopy-for-stone-disease-in-paediatric-population-is-safe-and-effective-in-medium-volume-and-high-volume-centres-evidence-from-a-systematic-review
#20
REVIEW
Shazna Rob, Patrick Jones, Amelia Pietropaolo, Stephen Griffin, Bhaskar K Somani
PURPOSE OF REVIEW: The incidence of urinary stone disease among the paediatric population is increasing. Whilst there has been a rise in the number of original studies published on ureteroscopy (URS) in children, critical review still remains under-reported. RECENT FINDINGS: A Cochrane style systematic review was performed to identify all original articles on URS (minimum of 25 cases) for stone disease in paediatric patients between Jan. 1996 and Dec. 2016. Based on the number of reported cases, centres were divided into medium (25-49 cases) and high (≥ 50 cases) volume studies...
October 18, 2017: Current Urology Reports
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