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Topical haemostat

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https://www.readbyqxmd.com/read/29334308/neuromuscular-degenerative-effects-of-ankaferd-blood-stopper%C3%A2-in-mouse-sciatic-nerve-model
#1
Ramazan Üstün, Elif Kaval Oğuz, Çağrı Delilbaşı, Ayşe Şeker, Filiz Taşpınar, Mehmet Reşit Öncü, Ahmet Regaip Oğuz
Purpose Ankaferd Blood Stopper® (ABS), a licenced medicinal herbal extract, is commonly used as an effective topical haemostatic agent. This study is designed to investigate whether topical ABS application may cause peripheral nerve degeneration and neuromuscular dysfunction in a mouse sciatic nerve model. Methods Twenty mice were randomly divided into two groups; an ABS treated experimental group and a saline-treated control group. Left sciatic nerves were treated with 0.3 ml of ABS in the experimental group and 0...
January 15, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29244748/design-of-new-generation-usable-forms-of-topical-haemostatic-agents-containing-chitosan
#2
Dorota Zielińska, Marcin H Struszczyk, Longina Madej-Kiełbik, Edyta Chmal-Fudali, Magdalena Kucharska, Maria Wiśniewska-Wrona, Kinga Brzoza-Malczewska
Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and chitosan/alginate impregnated gauze. Both of the usable forms of the topical haemostatic agent, being the main part of the modified combat gauze, were fabricated using the chitosan/alginate complex...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28942686/fibrin-glue-for-local-haemostasis-in-haemophilia-surgery
#3
E Carlos Rodriguez-Merchan
INTRODUCTION: Local fibrin glue (FG) appears to be a useful local haemostatic agent for severe haemorrhage in people with haemophilia (PWH) undergoing surgical procedures. AIM: To evaluate the role of local FG in PWH. METHODS: A review of the literature on the topic has been performed. RESULTS: Local FG is not always necessary to achieve haemostasis in all surgical procedures performed in PWH. However, it could be a good adjunct therapy, primarily when a surgical field will bleed more than expected (e...
October 3, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28902830/-use-of-tachocomb-agent-in-cardiovascular-surgery
#4
I M Ignat'ev, S V Moiseev
The article contains a review of the literature concerning the use of the Tachocomb haemostatic sponge in cardiovascular surgery. This is followed by enumerating the pharmacological properties of the agent, mechanism of its action, and methods of application. Also shown herein is a high haemostatic effect of the sponge, exceeding that of other means of topical haemostasis. Both safety and a hypoallergenic nature make it possible to widely use Tachocomb in surgical practice.
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28853336/the-percutaneous-absorption-of-soman-in-a-damaged-skin-porcine-model-and-the-evaluation-of-woundstat%C3%A2-as-a-topical-decontaminant
#5
Christopher Dalton, Charlotte Hall, Helen Lydon, John Jenner, J Kevin Chipman, John S Graham, Robert P Chilcott
PURPOSE: The aim of this study was to evaluate a candidate haemostat (WoundStat™), down-selected from previous in vitro studies, for efficacy as a potential skin decontaminant against the chemical warfare agent pinacoyl methylfluorophosphonate (Soman, GD) using an in vivo pig model. MATERIALS AND METHODS: An area of approximately 3 cm(2) was dermatomed from the dorsal ear skin to a nominal depth of 100 µm. A discrete droplet of (14)C-GD (300 µg kg(-1)) was applied directly onto the surface of the damaged skin at the centre of the dosing site...
August 30, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28852294/a-spilt-head-study-of-efficacy-of-placebo-versus-platelet-rich-plasma-injections-in-the-treatment-of-androgenic-alopecia
#6
Dilip Kachhawa, Gauri Vats, Durgesh Sonare, Pankaj Rao, Sandeep Khuraiya, Rohit Kataiya
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma with haemostatic and tissue repairing effects. Being enriched by various growth factors, PRP has become the focus of attention in numerous fields of medicine. Androgenic alopecia (AGA) is a common chronic hair loss disorder, characterised by progressive hair loss. Despite the therapeutic options available, there is low patient compliance and satisfaction rate...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28630388/spontaneous-liver-rupture-associated-with-anticoagulant-therapy-a-case-report
#7
Marco Clementi, Sara Colozzi, Stefano Guadagni, Beatrice Pessia, Federico Sista, Mario Schietroma, Andrea Della Penna, Gianfranco Amicucci
Spontaneous hepatic rupture without underlying liver diseases is uncommon entity. We report a rare case of spontaneous rupture of liver hematoma in patient treated with warfarin end enoxaparin sodium because of pulmonary embolism. Two day after admission the patient complained generalized abdominal pain and hemodynamic instability. The abdominal US and TC scan revealed free fluid and lesion at right liver lobe. The patient, despite intravenous fluid support and blood transfusion, was hemodinamically instable and urgent laparotomy was needed...
January 20, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28397668/-topical-haemostatic-agents-in-neurosurgery
#8
Jon Foss-Skiftesvik, Rachid Bech-Azeddine
Haemostasis is of fundamental significance in neurosurgery, and insufficient control of bleeding is associated with morbidity and mortality. Topical haemostatic agents play an important role, as the characteristics of neuronal tissue limit the use of classical surgical haemostasis techniques. Appropriate choice of agent depends on the location and type of bleeding, but also on knowledge of the products' mechanisms of action, indications, price and accessibility. Biological products are superior to the mechanical in efficacy but require more preparation and are significantly more cost-intensive...
January 30, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28218409/development-of-haemostatic-decontaminants-for-treatment-of-wounds-contaminated-with-chemical-warfare-agents-3-evaluation-of-in-vitro-topical-decontamination-efficacy-using-damaged-skin
#9
Helen L Lydon, Charlotte A Hall, Christopher H Dalton, J Kevin Chipman, John S Graham, Robert P Chilcott
Previous studies have demonstrated that haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD)...
February 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28218394/cross-sectional-observational-study-of-the-availability-of-evidence-supporting-novel-implantable-devices-used-in-gastrointestinal-surgery
#10
S J Chapman, B Shelton, M Maruthappu, P Singh, P McCulloch, A Bhangu
BACKGROUND: Evidence supporting the implementation of novel surgical devices is unstandardized, despite recommendations for assessing novel innovations. This study aimed to determine the proportion of novel implantable devices used in gastrointestinal surgery that are supported by evidence from RCTs. METHODS: A list of novel implantable devices placed intra-abdominally during gastrointestinal surgery was produced. Systematic searches were performed for all devices via PubMed and clinical trial registries...
May 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28151829/haemotherapy-algorithm-for-the-management-of-trauma-induced-coagulopathy-an-australian-perspective
#11
REVIEW
James Winearls, Biswadev Mitra, Michael C Reade
PURPOSE OF REVIEW: Recent advances in the understanding of the pathophysiological processes associated with traumatic haemorrhage and trauma-induced coagulopathy have resulted in improved outcomes for seriously injured trauma patients. However, a significant number of trauma patients still die from haemorrhage. This article reviews the various transfusion strategies utilized in the management of traumatic haemorrhage and describes the major haemorrhage protocol (MHP) strategy employed by an Australian trauma centre...
April 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27788559/reducing-inflow-occlusion-occlusion-duration-and-blood-loss-during-hepatic-resections
#12
Ya Ruth Huo, Tim Shiraev, Nayef Alzahrani, Francis Chu
BACKGROUND: To assess the changes in blood loss during hepatic resection with improved haemostatic devices such as a bipolar sealing device and a topical haemostatic agent. METHODS: This retrospective clinical study of prospectively collected data will assess hepatic resections performed by a single surgeon between 2005 and 2013, with the introduction of the two haemostatic techniques in 2009. RESULTS: A total of 371 hepatic resections (214 from 2005 to 2008 and 157 from 2009 to 2013) were included in this study...
October 27, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27631446/-the-new-german-guideline-on-postpartum-haemorrhage-pph-essential-aspects-for-coagulation-and-circulatory-therapy
#13
Heiko Lier, Dietmar Schlembach, Wolfgang Korte, Christian von Heymann, Susanne Steppat, Maritta Kühnert, Holger Maul, Wolfgang Henrich, Werner Rath, Jürgen Wacker, Franz Kainer, Daniel Surbek, Hanns Helmer
Worldwide, post-partum haemorrhage (PHH) remains one of the leading causes for maternal mortality. The German Society of Gynaecology and Obstetrics, the German Midwifes' Society, the German Society of Thrombosis and Haemostasis and the German Society of Anaesthesiology and Intensive Care updated the former guideline. The resulting recommendations are the results of a structured literature search and a formal consensus process and contain all aspects of PPH including diagnosis, causes, risk factors and therapy...
September 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27580747/an-update-on-topical-haemostatic-agents-in-liver-surgery-systematic-review-and-meta-analysis
#14
REVIEW
Raffaele Brustia, Benjamin Granger, Olivier Scatton
Mortality and morbidity in hepatic surgery are affected by blood loss and transfusion. Topical haemostatic agents (THA) are composed by a matrix and/or fibrin sealants, and their association known as "carrier-bound fibrin sealant" (CBFS): despite widely used for secondary haemostasis, the level of evidence remains low. To realize a meta-analysis on the results of CBFS on haemostasis and postoperative complications. Searches in PubMed, PubMed Central, Cochrane and Google Scholar using keywords: "topical_haemostasis" OR "haemostatic_agents" OR "sealant_patch" OR "fibrin_sealant" OR "collagen_sealant" AND "liver_surgery" OR "hepatic_surgery" OR "liver_transplantation"...
October 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27402483/erratum-to-comparison-of-the-topical-haemostatic-efficacy-of-nano-micro-particles-of-clinoptilolite-and-kaolin-in-a-rat-model-of-haemorrhagic-injury
#15
A Bayır, M Eryılmaz, M Demirbilek, E B Denkbaş, I Arzıman, M Durusu
No abstract text is available yet for this article.
December 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/27061269/fibrin-the-preferred-scaffold-for-cell-transplantation-after-myocardial-infarction-an-old-molecule-with-a-new-life
#16
REVIEW
Santiago Roura, Carolina Gálvez-Montón, Antoni Bayes-Genis
Fibrin is a topical haemostat, sealant and tissue glue, which consists of concentrated fibrinogen and thrombin. It has broad medical and research uses. Recently, several studies have shown that engineered patches comprising mixtures of biological or synthetic materials and progenitor cells showed therapeutic promise for regenerating damaged tissues. In that context, fibrin maintains cell adherence at the site of injury, where cells are required for tissue repair, and offers a nurturing environment that protects implanted cells without interfering with their expected benefit...
August 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27017161/a-multicentre-prospective-randomized-controlled-trial-comparing-evarrest%C3%A2-fibrin-sealant-patch-to-standard-of-care-in-controlling-bleeding-following-elective-hepatectomy-anatomic-versus-non-anatomic-resection
#17
RANDOMIZED CONTROLLED TRIAL
Jonathan B Koea, Jonathan Batiller, Nicolas Aguirre, Jessica Shen, Richard Kocharian, Grant Bochicchio, O James Garden
BACKGROUND: This multicentre, randomized clinical trial assessed the safety and effectiveness of the EVARREST™ Fibrin Sealant Patch (FP) in treating parenchymal bleeding following anatomic and non-anatomic liver resections. METHODS: One hundred and two patients were stratified according to the type of hepatic resection (anatomic/non-anatomic), and randomized (1:1) after identification of an appropriate bleeding site, to FP vs Standard of Care (SoC, manual compression ± topical haemostat)...
March 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27015755/use-of-a-novel-saline-bipolar-radiofrequency-energy-instrument-as-an-adjunct-for-arresting-ongoing-solid-organ-surface-and-laceration-bleeding-in-critically-injured-patients
#18
Chad G Ball, Andre Campbell, Sean C Grondin, Elijah Dixon, Joseph DuBose, Paul B McBeth, Rohan Lall
INTRODUCTION: Solid organ (liver, spleen and kidney) haemorrhage is often life threatening and can be difficult to stop in critically ill patients. Traditional techniques for arresting this ongoing bleeding include coagulation by high voltage cautery (Bovie), topical haemostatic application, and the delivery of ignited argon gas. The goal of this study was to evaluate the efficacy of a new energy device for arresting persistent solid organ haemorrhage. PATIENTS AND METHODS: A novel instrument utilizing bipolar radiofrequency (RF) energy which acts to ignite/boil dripping saline from a simple hand piece was employed to arrest ongoing bleeding from solid organ injuries at 2 high volume, level 1 trauma centres...
September 2016: Injury
https://www.readbyqxmd.com/read/26925418/qualitative-chemical-analyses-of-ankaferd-hemostat-and-its-antioxidant-content-in-synthetic-gastric-fluids
#19
Ahmet Koluman, Nejat Akar, Umit Y Malkan, Ibrahim C Haznedaroglu
INTRODUCTION: Ankaferd hemostat (ABS) is the first topical haemostatic agent involving the red blood cell-fibrinogen interactions. The antihemorrhagic efficacy of ABS has been tested in controlled clinical trials. The drug induces the formation of an encapsulated complex protein web with vital erythroid aggregation. The aim of this study is to detect the essential toxicity profile and the antioxidant molecules inside ABS. METHODS: The pesticides were analyzed by GC-MS and LC-MS...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26636489/clinician-reported-ease-of-use-for-a-novel-fibrin-sealant-patch-for-hemostasis-results-from-four-randomized-controlled-trials
#20
M Corral, N Ferko, S Hollmann, A Hogan, N Jamous, J Batiller, J Shen
BACKGROUND: In addition to rapid and sustained efficacy, ease of use is also an important characteristic of topical hemostats. OBJECTIVES: To evaluate clinician-reported ease of use for the Evarrest fibrin sealant patch across various surgical bleeding situations. METHODS: An ease of use questionnaire (EUQ) was validated and administered in four randomized studies comparing the fibrin sealant patch to standard of care (SoC) in soft tissue and hepatic surgical bleeding...
2016: Current Medical Research and Opinion
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