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Lewy bodies hallucinations

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https://www.readbyqxmd.com/read/27911311/risk-factors-and-pathological-substrates-associated-with-agitation-aggression-in-alzheimer-s-disease-a-preliminary-study-using-nacc-data
#1
Simrin Sennik, Tom A Schweizer, Corinne E Fischer, David G Munoz
BACKGROUND: Neuropsychiatric symptoms are common manifestations of Alzheimer's disease (AD). A number of studies have targeted psychosis, i.e., hallucinations and delusions in AD, but few have assessed agitation/aggression in AD. OBJECTIVE: To investigate the risk factors and pathological substrates associated with presence [A(+)] and absence [A(-)] of agitation/aggression (A) in autopsy-confirmed AD. METHODS: Data was collected from the UDS data as of 2015 on the NACC database...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27897064/diagnosis-of-dementia-with-lewy-bodies-can-123-i-imp-and-123-i-mibg-scintigraphy-yield-new-core-features
#2
Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
OBJECTIVE: Since the clinical symptoms of different types of dementia frequently overlap, especially in the earlier stages at onset, it is difficult to distinguish dementias with Lewy bodies (DLB) from other neurodegenerative dementias based on their clinical manifestations alone. Nuclear medicine imaging has been reported as a high-value index for the objective evaluation and diagnosis of DLB. The aim of this study was to evaluate whether nuclear medicine imaging findings may yield core features to be added to the diagnosis of DLB...
November 29, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27794030/concomitant-ad-pathology-affects-clinical-manifestation-and-survival-in-dementia-with-lewy-bodies
#3
A W Lemstra, M H de Beer, C E Teunissen, C Schreuder, P Scheltens, W M van der Flier, S A M Sikkes
OBJECTIVE: To investigate whether concomitant Alzheimer's disease (AD) pathology, reflected by cerebrospinal fluid (CSF) biomarkers, has an impact on dementia with Lewy bodies (DLB) in terms of clinical presentation, cognitive decline, nursing home admittance and survival. PARTICIPANTS: We selected 111 patients with probable DLB and CSF available from the Amsterdam Dementia Cohort. On the basis of the AD biomarker profile (CSF tau/amyloid-β 1-42 (Aβ42) ratio >0...
October 28, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27723861/high-frequency-of-gba-gene-mutations-in-dementia-with-lewy-bodies-among-ashkenazi-jews
#4
Tamara Shiner, Anat Mirelman, Mali Gana Weisz, Anat Bar-Shira, Elissa Ash, Ron Cialic, Naomi Nevler, Tanya Gurevich, Noa Bregman, Avi Orr-Urtreger, Nir Giladi
Importance: Mutations in the glucocerebrosidase (GBA) gene are a risk factor for the development of dementia with Lewy bodies (DLB). These mutations are common among Ashkenazi Jews (AJ) and appear to have an effect on the natural history of the disease. Objectives: To evaluate the clinical and genetic characteristics of an AJ cohort of patients diagnosed with DLB, assess the association of phenotype of DLB with GBA mutations, and explore the effects of these mutations on the clinical course of the disease...
October 10, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27592250/ligand-autoradiographical-quantification-of-histamine-h3-receptor-in-human-dementia-with-lewy-bodies
#5
Natasha L Lethbridge, Paul L Chazot
Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 receptors (H3R) in a series of major cortical and basal ganglia structures in human DLB and Alzheimer's (AD) post-mortem cases using the highly selective radioligand, [(3)H] GSK189254. In the main, the levels of H3 receptor were largely preserved in DLB cases when compared with aged-matched controls...
August 31, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27567844/paired-studies-comparing-clinical-profiles-of-lewy-body-dementia-with-alzheimer-s-and-parkinson-s-diseases
#6
Douglas W Scharre, Shu-Ing Chang, Haikady N Nagaraja, Ariane Park, Anahita Adeli, Punit Agrawal, Anne Kloos, Deb Kegelmeyer, Shannon Linder, Nora Fritz, Sandra K Kostyk, Maria Kataki
Limited data compares clinical profiles of Lewy Body Dementia (LBD) with Alzheimer's disease (AD) and Parkinson's disease (PD). Twenty-one mildly demented ambulatory LBD subjects were individually matched by MMSE score with 21 AD subjects and by UPDRS motor score with 21 PD subjects. Matched by age, gender, education, and race, pairs were compared using cognitive, functional, behavioral, and motor measures. LBD group performed worse than PD on axial motor, gait, and balance measures. AD had more amnesia and orientation impairments, but less executive and visuospatial deficits than LBD subjects...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27553583/visual-signs-and-symptoms-of-corticobasal-degeneration
#7
REVIEW
Richard A Armstrong
Corticobasal degeneration is a rare, progressive neurodegenerative disease and a member of the 'parkinsonian' group of disorders, which also includes Parkinson's disease, progressive supranuclear palsy, dementia with Lewy bodies and multiple system atrophy. The most common initial symptom is limb clumsiness, usually affecting one side of the body, with or without accompanying rigidity or tremor. Subsequently, the disease affects gait and there is a slow progression to influence ipsilateral arms and legs. Apraxia and dementia are the most common cortical signs...
November 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27540431/brain-18-f-fdg-18-f-florbetaben-pet-ct-123-i-fp-cit-spect-and-cardiac-123-i-mibg-imaging-for-diagnosis-of-a-cerebral-type-of-lewy-body-disease
#8
Axel Van Der Gucht, Laurent Cleret de Langavant, Ophélie Bélissant, Corentin Rabu, Anne-Ségolène Cottereau, Eva Evangelista, Julia Chalaye, Sophie Bonnot-Lours, Gilles Fénelon, Emmanuel Itti
A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. (18)F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but (123)I-FP-CIT SPECT was normal and cardiac (123)I-MIBG imaging showed no signs of sympathetic denervation...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27527713/delirium-prior-to-dementia-as-a-clinical-phenotype-of-lewy-body-disease-an-autopsied-case-report
#9
Hiroshige Fujishiro, Ito Kawakami, Kenichi Oshima, Kazuhiro Niizato, Shuji Iritani
Although delirium shares clinical characteristics with dementia with Lewy bodies (DLB), there is limited information regarding the relationship between delirium and Lewy body pathology. Here, we report an 89-year-old Japanese woman with an episode of delirium who was pathologically confirmed to have limbic-type Lewy body disease (LBD). Although she exhibited transient visual hallucinations during the delirium, she had no overt dementia. She developed no core clinical features of DLB and died of pneumonia at the age of 90 years...
August 16, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27511183/evolution-of-clinical-features-in-possible-dlb-depending-on-fp-cit-spect-result
#10
Zuzana Walker, Emilio Moreno, Alan Thomas, Fraser Inglis, Naji Tabet, Tim Stevens, Tim Whitfield, Dag Aarsland, Michael Rainer, Alessandro Padovani
OBJECTIVE: To test the hypothesis that core and suggestive features in possible dementia with Lewy bodies (DLB) would vary in their ability to predict an abnormal dopamine transporter scan and therefore a follow-up diagnosis of probable DLB. A further objective was to assess the evolution of core and suggestive features in patients with possible DLB over time depending on the (123)I-FP-CIT SPECT scan result. METHODS: A total of 187 patients with possible DLB (dementia plus one core or one suggestive feature) were randomized to have dopamine transporter imaging or to follow-up without scan...
September 6, 2016: Neurology
https://www.readbyqxmd.com/read/27502301/parkinson-disease-and-dementia
#11
Sara Garcia-Ptacek, Milica G Kramberger
Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present...
September 2016: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/27484179/grey-matter-atrophy-in-prodromal-stage-of-dementia-with-lewy-bodies-and-alzheimer-s-disease
#12
Frederic Blanc, Sean J Colloby, Benjamin Cretin, Paulo Loureiro de Sousa, Catherine Demuynck, John T O'Brien, Catherine Martin-Hunyadi, Ian McKeith, Nathalie Philippi, John-Paul Taylor
BACKGROUND: Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). METHODS: In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer's disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0...
2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27475955/phenotypic-differences-based-on-staging-of-alzheimer-s-neuropathology-in-autopsy-confirmed-dementia-with-lewy-bodies
#13
Guerry M Peavy, Steven D Edland, Belinda M Toole, Lawrence A Hansen, Douglas R Galasko, Ann M Mayo
INTRODUCTION: The goal was to compare subgroups of dementia with Lewy Bodies (DLB) using neuropathological measures to differentiate 'pure' Lewy body (LB) dementia from 'mixed' DLB [co-occurring LB and Alzheimer's disease (AD) pathology] to facilitate diagnostic decision-making and future development of interventions based on predicted type(s) of neuropathology. Studies comparing these groups are rare relative to those differentiating 'pure' AD and all-cause DLB, and are limited by insufficient sample size, brief cognitive batteries, and/or absence of autopsy confirmation...
October 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27458607/trem2-p-r47h-substitution-is-not-associated-with-dementia-with-lewy-bodies
#14
Ronald L Walton, Alexandra I Soto-Ortolaza, Melissa E Murray, Oswaldo Lorenzo-Betancor, Kotaro Ogaki, Michael G Heckman, Sruti Rayaprolu, Rosa Rademakers, Nilüfer Ertekin-Taner, Ryan J Uitti, Jay A van Gerpen, Zbigniew K Wszolek, Glenn E Smith, Kejal Kantarci, Val J Lowe, Joseph E Parisi, David T Jones, Rodolfo Savica, Jonathan Graff-Radford, David S Knopman, Ronald C Petersen, Neill R Graff-Radford, Tanis J Ferman, Dennis W Dickson, Bradley F Boeve, Owen A Ross, Catherine Labbé
Dementia with Lewy bodies (DLB) is the second leading cause of neurodegenerative dementia in the elderly and is clinically characterized by the presence of cognitive decline, parkinsonism, REM sleep behavior disorder, and visual hallucinations.(1,2) At autopsy, α-synuclein-positive Lewy-related pathology is observed throughout the brain. Concomitant Alzheimer disease-related pathology including amyloid plaques and, to a lesser degree, neurofibrillary tangles are often present.(2) The clinical characteristics of DLB share overlapping features with Alzheimer disease dementia (AD) and Parkinson disease (PD)...
August 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27403372/evaluation-of-nonmotor-symptoms-in-diagnosis-of-parkinsonism-and-tremor
#15
Andrew H Evans, Chiun-Hian Chai
Background. Nonmotor symptoms particularly olfactory dysfunction, RBD, depression, hallucinations, and constipation are currently not included in the typical clinical criteria for diagnosing Lewy body Parkinsonian disorders (LBPD). The aim of this study is to determine the diagnostic value of nonmotor symptoms in patients presenting with Parkinsonism and tremor. Methods. All new patients seen between January 2007 and May 2013 in the Movement Disorders Specialist Clinics of the Royal Melbourne Hospital (RMH), who were referred with a possible neurodegenerative syndrome or concerns of Parkinsonism and/or tremor, were included...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27372647/neurocognitive-deficits-distinguishing-mild-dementia-with-lewy-bodies-from-mild-alzheimer-s-disease-are-associated-with-parkinsonism
#16
Kolbørn Brønnick, Monica H Breitve, Arvid Rongve, Dag Aarsland
BACKGROUND: The cognitive profile of mild dementia with Lewy bodies (DLB) versus mild Alzheimer's disease (AD) has not been extensively studied, and the relation of cognitive deficits to the core diagnostic criteria for DLB (fluctuations, visual hallucinations, and parkinsonism) remains poorly understood. OBJECTIVE: To compare the cognitive profile in patients with mild DLB to patients with mild AD and investigate the relation between cognitive deficits distinguishing DLB from AD and the core diagnostic features in DLB...
June 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27370065/-hoarding-behav%C3%A4-our-in-three-different-types-of-dementia-cases
#17
Bilgen Biçer Kanat, Umut Altunöz, Sevinç Kırıcı, Gülbahar Baştuğ, Erguvan Tuğba Özel Kızıl
INTRODUCTION: Hoarding behaviour, which is generally defined as collecting and keeping unnecessary, cheap objects or things that can not be used, is more common in elderly than young people. The prevelance of hoarding behaviour in dementia was reported as 22%. In this paper, three different types of dementia cases are presented in order to emphasize the clinical awareness for hoarding disorder, which is common in the elderly, especially those with dementia. CASES: The first case is a patient with a diagnosis of frontotemporal dementia who was collecting old things before the appearance of bahavioural changes like verbal and physical agitation...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27357212/analysis-of-primary-visual-cortex-in-dementia-with-lewy-bodies-indicates-gabaergic-involvement-associated-with-recurrent-complex-visual-hallucinations
#18
Ahmad A Khundakar, Peter S Hanson, Daniel Erskine, Nichola Z Lax, Joseph Roscamp, Evangelia Karyka, Eliona Tsefou, Preeti Singh, Simon J Cockell, Andrew Gribben, Lynne Ramsay, Peter G Blain, Urs P Mosimann, Deborah J Lett, Matthias Elstner, Douglass M Turnbull, Charles C Xiang, Michael J Brownstein, John T O'Brien, John-Paul Taylor, Johannes Attems, Alan J Thomas, Ian G McKeith, Christopher M Morris
Dementia with Lewy bodies (DLB) patients frequently experience well formed recurrent complex visual hallucinations (RCVH). This is associated with reduced blood flow or hypometabolism on imaging of the primary visual cortex. To understand these associations in DLB we used pathological and biochemical analysis of the primary visual cortex to identify changes that could underpin RCVH. Alpha-synuclein or neurofibrillary tangle pathology in primary visual cortex was essentially absent. Neurone density or volume within the primary visual cortex in DLB was also unchanged using unbiased stereology...
June 30, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27356810/similarity-of-symptoms-between-transient-epileptic-amnesia-and-lewy-body-disease
#19
Katsuyuki Ukai, Hiroshige Fujishiro, Masako Watanabe, Kenji Kosaka, Norio Ozaki
Epilepsy with the main symptom of amnesia is known as transient epileptic amnesia (TEA). Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia. The concept that Lewy body disease includes Parkinson's disease with dementia and dementia with Lewy bodies was proposed in the 2005 revision of the Clinical Diagnostic Criteria. Here, we describe a woman with cognitive impairment, olfactory dysfunction, and reduced (123) I-meta-iodobenzylguanidine uptake on myocardial scintigraphy...
June 30, 2016: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/27264344/the-prevalence-of-dementia-with-lewy-bodies-in-a-rural-area-of-china
#20
Wei Yue, Xiao-Dan Wang, Zhihong Shi, Yajing Wang, Shuai Liu, Shuling Liu, Ying Zhang, Yajing Zhang, Hui Lu, Wenhua Su, Yong Ji
INTRODUCTION: Data on the prevalence of dementia with Lewy bodies (DLB) in China are limited. The aim of this study was to estimate the prevalence of DLB in individuals aged 60 years and older and to analyze the associated risk factors and clinical features of DLB. METHODS: We conducted a cross-sectional, two-phase, door-to-door, population-based study that included 5542 participants aged at least 60 years who resided in Ji County. In phase I of the study, we used the Mini-Mental State Examination, the Clinical Dementia Rating scale, and the Activities of Daily Living scale to screen for dementia...
August 2016: Parkinsonism & related Disorders
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