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https://www.readbyqxmd.com/read/29204277/cytomegalovirus-mononucleosis-induced-thyroiditis-in-an-immunocompetent-patient
#1
V Larouche, M Tamilia
Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29181300/recurrence-of-escherichia-coli-meningitis-in-a-preterm-infant-and-co-infection-of-echovirus-18
#2
Kentaro Kato, Hiroshi Mizumoto, Kousaku Matsubara, Atsuko Hata, Jun-Ichi Wachino, Yoshichika Arakawa, Daisuke Hata
Introduction: Bacterial meningitis may relapse after adequate antibiotic treatment. In most cases, however, the pathophysiology cannot be identified. Presentation of case: We describe a preterm infant with recurrent episodes of meningitis due to infection with an identical Escherichia coli strain both at birth and at 10 days after cessation of a 3 week course of appropriate antibiotic treatment. At the time of recurrence, the patient presented with fulminant severe cardiac failure due to acute myocarditis, coupled with a concurrent echovirus 18 infection (confirmed by stool culture and serological analysis)...
2017: IDCases
https://www.readbyqxmd.com/read/29179969/-detection-of-herpes-virus-and-human-enterovirus-in-pathology-samples-using-low-density-arrays
#3
Sofía Del Carmen Martínez, Ruth Gervás Ríos, Yoana Franco Rodríguez, Cristina González Velasco, Miguel Ángel Cruz Sánchez, María Del Mar Abad Hernández
Despite the frequency of infections with herpesviridae family, only eight subtypes affect humans (Herpex Simplex Virus types 1 and 2, Varicella Zoster Virus, Epstein-Barr Virus, Citomegalovirus and Human Herpes Virus types 6, 7 and 8). Amongst enteroviruses infections, the most important are Poliovirus, Coxackievirus and Echovirus. Symptoms can vary from mild to severe and early diagnosis is of upmost importance. Nowadays, low-density arrays can detect different types of viruses in a single assay using DNA extracted from biological samples...
January 2017: Revista Española de Patología
https://www.readbyqxmd.com/read/29164043/antiviral-activity-of-itraconazole-against-echovirus-30-infection-in-vitro
#4
Jae-Sug Lee, Hwa-Jung Choi, Jae-Hyoung Song, Hyun-Jeong Ko, Kyungah Yoon, Jeong-Min Seong
Objectives: Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30. Methods: The cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known antiviral drugs, rupintrivir and pleconaril. The time course and time-of-addition assays were used to approximate the time at which itraconazole exerts its activity in the viral cycle...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29156511/molecular-epidemiology-and-prevalence-of-echovirus-30-in-zhejiang-province-china-from-2002-to-2015
#5
Yin Chen, Yi Sun, Juying Yan, Ziping Miao, Changping Xu, Yanjun Zhang, Haiyan Mao, Liming Gong
Echovirus 30 serotype (ECHO30) has been responsible for several, recent, worldwide outbreaks of viral meningitis. In Zhejiang Province, China, ECHO30 has been one of the main causes of viral meningitis for years. This study, using phylogenetic analysis on VP1 gene, was performed to investigate the general molecular epidemiology and genetic patterns of ECHO30 circulating in Zhejiang Province between the years 2002 and 2015. The nucleotide sequences of ECHO30 VP1 showed that they were 64.8% identical with the prototype strain, Bastianni, while the amino acids were 84...
November 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29134337/recombination-analysis-of-coxsackievirus-b5-genogroup-c
#6
Hongxing Shen
Coxsackievirus B5 (CVB5) is a member of the species Enterovirus B of the genus Enterovirus, family Picornaviridae. Based on its VP1 sequence, CVB5 is divided into four genogroups: A, B, C, and D. From 2002 to 2012, CVB5 serotype genogroup C caused an outbreak of aseptic meningitis in China. In order to study the evolution of CVB5 genogroup C, phylogenetic and recombination analysis was performed using the 399 available enterovirus B genome sequences in the GenBank database. The results indicated that 10 strains of CVB5 serotype genogroup C resulted from recombination between members of genogroup B and echovirus serotype E6, and another 5 strains resulted from recombination between members of genogroup C and serotype CVB4...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29116409/chronic-meningoencephalitis-caused-by-echo-virus%C3%A2-6-in-a%C3%A2-patient-with-common-variable-immunodeficiency-successful-treatment-with-pleconaril
#7
Igor Radanović, Deni Rkman, Paulo Zekan, Marko Kutleša, Bruno Baršić
Chronic enteroviral meningoencephalitis, most commonly caused by echoviruses, can particularly be seen in agammaglobulinemic patients. In spite of the fact that no specific treatment for enteroviral infections exists, pleconaril is an antiviral drug reported to be efficient against enteroviral infections in infants and adults. We present a case of a 42-year-old male, previously diagnosed with common variable immunodeficiency, who presented with severe chronic meningoencephalitis caused by Echo virus 6 and was successfully treated with pleconaril...
November 7, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29046672/cross-resistance-of-uv-or-chlorine-dioxide-resistant-echovirus-11-to-other-disinfectants
#8
Qingxia Zhong, Anna Carratalà, Rachele Ossola, Virginie Bachmann, Tamar Kohn
The emergence of waterborne viruses with resistance to disinfection has been demonstrated in the laboratory and in the environment. Yet, the implications of such resistance for virus control remain obscure. In this study we investigate if viruses with resistance to a given disinfection method exhibit cross-resistance to other disinfectants. Chlorine dioxide (ClO2)- or UV-resistant populations of echovirus 11 were exposed to five inactivating treatments (free chlorine, ClO2, UV radiation, sunlight, and heat), and the extent of cross-resistance was determined...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29038056/worldwide-prevalence-of-viral-infection-in-aecopd-patients-a-meta-analysis
#9
REVIEW
Habib Jafarinejad, Mohsen Moghoofei, Shayan Mostafaei, Jafar Salimian, Sadegh Azimzadeh Jamalkandi, Ali Ahmadi
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. METHODS: PubMed database was systematically searched for population-based prevalence studies (1930-2017). Fixed and random effects models were used for estimation of summary effect-sizes...
October 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28979010/hand-foot-and-mouth-disease-in-west-bengal-india-a-preliminary-report-on-clinicovirological-trend-over-3-successive-years-2013-2015
#10
Nilendu Sarma, Sayantani Chakraborty, Abira Dutta, Provash Chandra Sadhukhan
INTRODUCTION: Hand, foot, and mouth disease (HFMD), an enteroviral disease has emerged as a major emerging infection in India. This is caused most commonly by enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) but can also be due to CVA4-10, CVA24, CVB2-5, and echovirus 18 (Echo18). Virological analysis of the cases of HFMD has been infrequently done in India. West Bengal is one of the worst affected states in India. OBJECTIVE: To document the clinical and etiological aspect, the changing patterns and clinic-virological correlation...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28960178/cpg-and-upa-dinucleotides-in-both-coding-and-non-coding-regions-of-echovirus-7-inhibit-replication-initiation-post-entry
#11
Jelke Jan Fros, Isabelle Dietrich, Kinda Alshaikhahmed, Tim Casper Passchier, David John Evans, Peter Simmonds
Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several cell types, we show that the restriction in E7 replication in mutants with increased CpG/UpA dinucleotides occurred immediately after viral entry, with incoming virions failing to form replication complexes. Sequences of CpG/UpA-high virus stocks showed no evidence of increased mutational errors that would render them replication defective, these viral RNAs were not differentially sequestered in cytoplasmic stress granules nor did they induce a systemic antiviral state...
September 29, 2017: ELife
https://www.readbyqxmd.com/read/28948184/acute-liver-failure-due-to-echovirus-9-associated-with-persistent-b-cell-depletion-from-rituximab
#12
Kristina L Bajema, Paul D Simonson, Alex L Greninger, Basak Çoruh, Paul S Pottinger, Renuka Bhattacharya, Iris W Liou, Florencia G Jalikis, Corinne L Fligner, Robert M Rakita
We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28927425/erratum-to-metabolomics-of-rhabdomyosarcoma-cell-during-echovirus-30-infection
#13
Sarika Tiwari, Tapan N Dhole
No abstract text is available yet for this article.
September 19, 2017: Virology Journal
https://www.readbyqxmd.com/read/28899311/australian-national-enterovirus-reference-laboratory-annual-report-2014
#14
Jason Roberts, Linda Hobday, Aishah Ibrahim, Thomas Aitken, Bruce Thorley
Following the World Health Organization (WHO) recommendation, Australia conducts surveillance for cases of acute flaccid paralysis (AFP) in children less than 15 years of age as the main method to monitor its polio-free status. Cases of AFP in children are notified to the Australian Paediatric Surveillance Unit or the Paediatric Active Enhanced Disease Surveillance System and faecal specimens are referred for virological investigation to the National Enterovirus Reference Laboratory. In 2014, no cases of poliomyelitis were reported from clinical surveillance and Australia reported 1...
June 30, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28857219/non-polio-enterovirus-detection-with-acute-flaccid-paralysis-a-systematic-review
#15
Sneha Suresh, Sarah Forgie, Joan Robinson
Acute flaccid paralysis (AFP), as defined by the World Health Organization (WHO), is characterized by an acute onset of limb weakness. In the post-polio era, other enterovirus (EV) serotypes associated with AFP may become more prominent. This study aims to collate the data on the non-polio enteroviruses (NPEV) associated with AFP. A systematic review of published case reports, case series, and surveillance studies of AFP from 1960 through 2017 was undertaken. Data were collected including the country of the study, number of specimens positive for NPEV and available clinical data...
August 31, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28837336/resistance-of-echovirus-11-to-clo2-is-associated-with-enhanced-host-receptor-use-altered-entry-routes-and-high-fitness
#16
Qingxia Zhong, Anna Carratalà, Hyunjin Shim, Virginie Bachmann, Jeffrey D Jensen, Tamar Kohn
Waterborne viruses can exhibit resistance to common water disinfectants, yet the mechanisms that allow them to tolerate disinfection are poorly understood. Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental evolution, and we assessed the associated genotypic and phenotypic traits. ClO2 resistance emerged after E11 populations were repeatedly reduced (either by ClO2-exposure or by dilution) and then regrown in cell culture. The resistance was linked to an improved capacity of E11 to bind to its host cells, which was further attributed to two potential causes: first, the resistant E11 populations possessed mutations that caused amino acid substitutions from ClO2-labile to ClO2-stable residues in the viral proteins, which likely increased the chemical stability of the capsid toward ClO2...
September 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28814774/molecular-characterization-of-two-novel-echovirus-18-recombinants-associated-with-hand-foot-mouth-disease
#17
Haihao Zhang, Yilin Zhao, Hongbo Liu, Hao Sun, Xiaoqin Huang, Zhaoqing Yang, Shaohui Ma
Human echovirus 18 (E-18) is a member of the enterovirus B species. To date, sixteen full-length genome sequences of E-18 are available in the GenBank database. In this study, we describe the complete genomic characterization of two E-18 strains isolated in Yunnan, China. Pairwise comparisons of the nucleotide sequences and the deduced amino acid sequences revealed that the two Yunnan E-18 strains had 87.5% nucleotide identity and 96.3-96.5% amino acid identity with the Chinese strain. Phylogenetic and bootscanning analyses revealed the two E-18 strains had the highest identity with other several EV-B serotypes than the other E-18 strains in the P3 coding region, especially, 3B region of the Swine Vesicular disease virus (SVDV) strain HK70, indicated that frequent intertypic recombination might have occurred in the two Yunnan strains...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806062/exploring-strategies-for-labeling-viruses-with-gold-nanoclusters-through-non-equilibrium-molecular-dynamics-simulations
#18
Emmi Pohjolainen, Sami Malola, Gerrit Groenhof, Hannu Häkkinen
Biocompatible gold nanoclusters can be utilized as contrast agents in virus imaging. The labeling of viruses can be achieved noncovalently but site-specifically by linking the cluster to the hydrophobic pocket of a virus via a lipid-like pocket factor. We have estimated the binding affinities of three different pocket factors of echovirus 1 (EV1) in molecular dynamics simulations combined with non-equilibrium free-energy calculations. We have also studied the effects on binding affinities with a pocket factor linked to the Au102pMBA44 nanocluster in different protonation states...
September 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28766163/seroepidemiology-of-echovirus-30-in-korean-children
#19
Joo Young Lee, Yumi Seo, Ui Yoon Choi, Jong-Hyun Kim, Jin Han Kang
BACKGROUND: Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern, no data have been reported on Children's immune status against echovirus type 30. The current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus 30. METHODS: Two hundred and fifty residual serum samples were collected at St. Paul's Hospital. Individuals were categorized by age into four groups: group 1 (3 months-2 years), group 2 (3-6 years), group 3 (7-10 years) and group 4 (11-15 years)...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28761901/metagenomic-sequencing-of-an-echovirus-30-genome-from-cerebrospinal-fluid-of-a-patient-with-aseptic-meningitis-and-orchitis
#20
Anne Piantadosi, Shibani S Mukerji, Pooja Chitneni, Tracey A Cho, Lisa A Cosimi, Deborah T Hung, Marcia B Goldberg, Pardis C Sabeti, Daniel R Kuritzkes, Yonatan H Grad
Enteroviruses cause a wide spectrum of clinical disease. In this study, we describe the case of a young man with orchitis and aseptic meningitis who was diagnosed with enterovirus infection. Using unbiased "metagenomic" massively parallel sequencing, we assembled a near-complete viral genome, the first use of this method for full-genome viral sequencing from cerebrospinal fluid. We found that the genome belonged to the subgroup echovirus 30, which is a common cause of aseptic meningitis but has not been previously reported to cause orchitis...
2017: Open Forum Infectious Diseases
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