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https://www.readbyqxmd.com/read/29466658/variability-in-disinfection-resistance-within-an-between-currently-circulating-enterovirus-b-serotypes
#1
Simon Meister, Matthew E Verbyla, Marius Klinger, Tamar Kohn
The susceptibility of waterborne viruses to disinfection is known to vary between viruses and even between closely related strains, yet the extent of this variation is not known. Here, different enteroviruses (six strains of coxsackievirus B5, two strains of coxsackievirus B4 and one strain of coxackievirus B1) were isolated from wastewater and inactivated by UV254 , sunlight, free chlorine (FC), chlorine dioxide (ClO2 ), and heat. Inactivation kinetics of these isolates were compared with those of laboratory enterovirus strains (CVB5 Faulkner and echovirus 11 Gregory) and MS2 bacteriophage...
February 21, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29463289/strain-dependent-effects-of-clinical-echovirus-30-outbreak-isolates-at-the-blood-csf-barrier
#2
Tobias Dahm, Ortwin Adams, Sindy Boettcher, Sabine Diedrich, Vasily Morozov, Grant Hansman, Petra Fallier-Becker, Sebastian Schädler, Claus J Burkhardt, Christel Weiss, Carolin Stump-Guthier, Hiroshi Ishikawa, Horst Schroten, Christian Schwerk, Tobias Tenenbaum, Henriette Rudolph
BACKGROUND: Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the blood-cerebrospinal fluid barrier (BCSFB), which has been demonstrated to be involved in enteroviral CNS pathogenesis, may affect the tight junction (TJ) and adherens junction (AJ) function and morphology. METHODS: We used an in vitro human choroid plexus epithelial (HIBCPP) cell model to investigate the effect of three clinical outbreak strains (13-311, 13-759, and 14-397) isolated in Germany in 2013, and compared them to E-30 Bastianni...
February 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29425680/new-coxsackievirus-2apro-and-3cpro-protease-antibodies-for-virus-detection-and-discovery-of-pathogenic-mechanisms
#3
Olli H Laitinen, Emma Svedin, Sebastian Kapell, Minna M Hankaniemi, Pär G Larsson, Erna Domsgen, Virginia M Stone, Juha A E Määttä, Heikki Hyöty, Vesa P Hytönen, Malin Flodström-Tullberg
Enteroviruses (EVs), such as the Coxsackie B-viruses (CVBs), are common human pathogens, which can cause severe disease including meningitis, myocarditis and neonatal sepsis. EVs encode two proteases (2Apro and 3Cpro), which perform the proteolytic cleavage of the CVB polyprotein and also cleave host cell proteins to facilitate viral replication. The 2Apro cause direct damage to the infected heart and tools to investigate 2Apro and 3Cpro expression may contribute new knowledge on virus-induced pathologies. Here, we developed new antibodies to CVB-encoded 2Apro and 3Cpro; Two monoclonal 2Apro antibodies and one 3Cpro antibody were produced...
February 6, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29410201/cerebrospinal-fluid-features-in-adults-with-enteroviral-nervous-system-infection
#4
Jonas Ahlbrecht, Lilly Katrin Hillebrand, Philipp Schwenkenbecher, Tina Ganzenmueller, Albert Heim, Ulrich Wurster, Martin Stangel, Kurt-Wolfram Sühs, Thomas Skripuletz
OBJECTIVES: The aim of the study was to investigate clinical and laboratory features in adults with enteroviral nervous system infection with special emphasis on cerebrospinal fluid (CSF). METHODS: Data of 46 patients with positive PCR for enteroviruses in the CSF between 2002 and 2017 were evaluated. RESULTS: Meningitis was the most common clinical manifestation (89%), followed by encephalitis (7%) and isolated cranial nerve affection (4%)...
February 1, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29407377/analysis-of-enterovirus-types-in-patients-with-symptoms-of-aseptic-meningitis-in-2014-in-shandong-china
#5
Peng Chen, Xiaojuan Lin, Guifang Liu, Suting Wang, Lizhi Song, Zexin Tao, Aiqiang Xu
We reviewed the epidemiological and clinical characteristics of 927 aseptic meningitis patients in Shandong in 2014, and the phylogeny of predominant enterovirus (EV) types causing this disease was analyzed. A total of 209 patients that were positive for EV were identified by both cell culture and a reverse transcription-seminested PCR in cerebrospinal fluid samples. The positive patients were most likely to be children within 15 years of age, had symptoms such as fever, vomiting and nausea (P< .05). The 209 EV sequences belonged to 11 types, and coxsackievirus B5, echovirus types 6 and 30 were predominant types...
January 30, 2018: Virology
https://www.readbyqxmd.com/read/29372173/acute-transverse-myelitis-caused-by-echovirus-11-in-a-pediatric-patient-case-report-and-review-of-the-current-literature
#6
Heidi L Moline, Peter I Karachunski, Anna Strain, Jayne Griffith, Cynthia Kenyon, Mark R Schleiss
A 12-year-old boy presented with acute flaccid weakness of the right upper extremity and was found to have acute flaccid myelitis with transverse myelitis involving the cervical cord (C1-T1). An interdisciplinary team-based approach was undertaken, including input from a generalist, an infectious diseases physician, and a pediatric neurologist. Consultation was sought from the Minnesota Department of Health to investigate for a potential etiology and source of the responsible infection. Evaluation for an infectious etiology demonstrated infection with human echovirus 11...
2018: Child Neurology Open
https://www.readbyqxmd.com/read/29356522/kinetics-of-inactivation-of-waterborne-enteric-viruses-by-ozone
#7
Camille Wolf, Urs von Gunten, Tamar Kohn
Ozone is an effective disinfectant against all types of waterborne pathogens. However, accurate and quantitative kinetic data regarding virus inactivation by ozone is scarce, due to the experimental challenges associated with the high reactivity of ozone towards viruses. Here, we established an experimental batch system that allows tailoring and quantifying very low ozone exposures and simultaneously measuring virus inactivation. Second-order ozone inactivation rate constants (kO3-virus) of five enteric viruses (laboratory and two environmental strains of coxsackievirus B5: CVF, CVEnv1 and CVEnv2, human adenovirus: HAdV, and echovirus 11: EV) and four bacteriophages (MS2, Qβ, T4 and Φ174) were measured in buffered solutions...
January 22, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29323107/serological-survey-of-neutralizing-antibodies-to-eight-major-enteroviruses-among-healthy-population
#8
Rui Zhu, Tong Cheng, Zhichao Yin, Dongxiao Liu, Longfa Xu, Yongchao Li, Wei Wang, Jian Liu, Yuqiong Que, Xiangzhong Ye, Qiyi Tang, Qinjian Zhao, Shengxiang Ge, Shuizhen He, Ningshao Xia
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29248990/large-scale-survey-of-human-enteroviruses-in-wastewater-treatment-plants-of-a-metropolitan-area-of-southern-italy
#9
Francesca Pennino, Antonio Nardone, Paolo Montuori, Sara Aurino, Ida Torre, Andrea Battistone, Roberto Delogu, Gabriele Buttinelli, Stefano Fiore, Concetta Amato, Maria Triassi
Human enteroviruses (HEVs) occur in high concentrations in wastewater and can contaminate receiving environmental waters, constituting a major cause of acute waterborne disease worldwide. In this study, we investigated the relative abundance, occurrence, and seasonal distribution of polio and other enteroviruses at three wastewater treatment plants (WWTPs) in Naples, Southern Italy, from January 2010 to December 2014. Influent and effluent samples from the three WWTPs were collected monthly. One hundred and sixty-one of the 731 wastewater samples collected (22...
December 16, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/29225923/experimental-adaptation-of-human-echovirus-11-to-ultraviolet-radiation-leads-to-resistance-to-disinfection-and-ribavirin
#10
Anna Carratalà, Hyunjin Shim, Qingxia Zhong, Virginie Bachmann, Jeffrey D Jensen, Tamar Kohn
Ultraviolet light in the UVC range is a commonly used disinfectant to control viruses in clinical settings and water treatment. However, it is currently unknown whether human viral pathogens may develop resistance to such stressor. Here, we investigate the adaptation of an enteric pathogen, human echovirus 11, to disinfection by UVC, and characterized the underlying phenotypic and genotypic changes. Repeated exposure to UVC lead to a reduction in the UVC inactivation rate of approximately 15 per cent compared to that of the wild-type and the control populations...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/29204277/cytomegalovirus-mononucleosis-induced-thyroiditis-in-an-immunocompetent-patient
#11
V Larouche, M Tamilia
Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29181300/recurrence-of-escherichia-coli-meningitis-in-a-preterm-infant-and-co-infection-of-echovirus-18
#12
Kentaro Kato, Hiroshi Mizumoto, Kousaku Matsubara, Atsuko Hata, Jun-Ichi Wachino, Yoshichika Arakawa, Daisuke Hata
Introduction: Bacterial meningitis may relapse after adequate antibiotic treatment. In most cases, however, the pathophysiology cannot be identified. Presentation of case: We describe a preterm infant with recurrent episodes of meningitis due to infection with an identical Escherichia coli strain both at birth and at 10 days after cessation of a 3 week course of appropriate antibiotic treatment. At the time of recurrence, the patient presented with fulminant severe cardiac failure due to acute myocarditis, coupled with a concurrent echovirus 18 infection (confirmed by stool culture and serological analysis)...
2017: IDCases
https://www.readbyqxmd.com/read/29179969/-detection-of-herpes-virus-and-human-enterovirus-in-pathology-samples-using-low-density-arrays
#13
Sofía Del Carmen Martínez, Ruth Gervás Ríos, Yoana Franco Rodríguez, Cristina González Velasco, Miguel Ángel Cruz Sánchez, María Del Mar Abad Hernández
Despite the frequency of infections with herpesviridae family, only eight subtypes affect humans (Herpex Simplex Virus types 1 and 2, Varicella Zoster Virus, Epstein-Barr Virus, Citomegalovirus and Human Herpes Virus types 6, 7 and 8). Amongst enteroviruses infections, the most important are Poliovirus, Coxackievirus and Echovirus. Symptoms can vary from mild to severe and early diagnosis is of upmost importance. Nowadays, low-density arrays can detect different types of viruses in a single assay using DNA extracted from biological samples...
January 2017: Revista Española de Patología
https://www.readbyqxmd.com/read/29164043/antiviral-activity-of-itraconazole-against-echovirus-30-infection-in-vitro
#14
Jae-Sug Lee, Hwa-Jung Choi, Jae-Hyoung Song, Hyun-Jeong Ko, Kyungah Yoon, Jeong-Min Seong
Objectives: Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30. Methods: The cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known antiviral drugs, rupintrivir and pleconaril. The time course and time-of-addition assays were used to approximate the time at which itraconazole exerts its activity in the viral cycle...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29156511/molecular-epidemiology-and-prevalence-of-echovirus-30-in-zhejiang-province-china-from-2002-to-2015
#15
Yin Chen, Yi Sun, Juying Yan, Ziping Miao, Changping Xu, Yanjun Zhang, Haiyan Mao, Liming Gong
Echovirus 30 serotype (ECHO30) has been responsible for several, recent, worldwide outbreaks of viral meningitis. In Zhejiang Province, China, ECHO30 has been one of the main causes of viral meningitis for years. This study, using phylogenetic analysis on VP1 gene, was performed to investigate the general molecular epidemiology and genetic patterns of ECHO30 circulating in Zhejiang Province between the years 2002 and 2015. The nucleotide sequences of ECHO30 VP1 showed that they were 64.8% identical with the prototype strain, Bastianni, while the amino acids were 84...
November 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29134337/recombination-analysis-of-coxsackievirus-b5-genogroup-c
#16
Hongxing Shen
Coxsackievirus B5 (CVB5) is a member of the species Enterovirus B of the genus Enterovirus, family Picornaviridae. Based on its VP1 sequence, CVB5 is divided into four genogroups: A, B, C, and D. From 2002 to 2012, CVB5 serotype genogroup C caused an outbreak of aseptic meningitis in China. In order to study the evolution of CVB5 genogroup C, phylogenetic and recombination analysis was performed using the 399 available enterovirus B genome sequences in the GenBank database. The results indicated that 10 strains of CVB5 serotype genogroup C resulted from recombination between members of genogroup B and echovirus serotype E6, and another 5 strains resulted from recombination between members of genogroup C and serotype CVB4...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29116409/chronic-meningoencephalitis-caused-by-echo-virus%C3%A2-6-in-a%C3%A2-patient-with-common-variable-immunodeficiency-successful-treatment-with-pleconaril
#17
Igor Radanović, Deni Rkman, Paulo Zekan, Marko Kutleša, Bruno Baršić
Chronic enteroviral meningoencephalitis, most commonly caused by echoviruses, can particularly be seen in agammaglobulinemic patients. In spite of the fact that no specific treatment for enteroviral infections exists, pleconaril is an antiviral drug reported to be efficient against enteroviral infections in infants and adults. We present a case of a 42-year-old male, previously diagnosed with common variable immunodeficiency, who presented with severe chronic meningoencephalitis caused by Echo virus 6 and was successfully treated with pleconaril...
November 7, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29046672/cross-resistance-of-uv-or-chlorine-dioxide-resistant-echovirus-11-to-other-disinfectants
#18
Qingxia Zhong, Anna Carratalà, Rachele Ossola, Virginie Bachmann, Tamar Kohn
The emergence of waterborne viruses with resistance to disinfection has been demonstrated in the laboratory and in the environment. Yet, the implications of such resistance for virus control remain obscure. In this study we investigate if viruses with resistance to a given disinfection method exhibit cross-resistance to other disinfectants. Chlorine dioxide (ClO2)- or UV-resistant populations of echovirus 11 were exposed to five inactivating treatments (free chlorine, ClO2, UV radiation, sunlight, and heat), and the extent of cross-resistance was determined...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29038056/worldwide-prevalence-of-viral-infection-in-aecopd-patients-a-meta-analysis
#19
REVIEW
Habib Jafarinejad, Mohsen Moghoofei, Shayan Mostafaei, Jafar Salimian, Sadegh Azimzadeh Jamalkandi, Ali Ahmadi
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a chronic progressive lung disease. On the other hand, viral infections of the airway are associated with the acute exacerbations of COPD. A systematic review and meta-analysis were performed to determine the prevalence rate of viral infections in acute exacerbations of COPD patients. METHODS: PubMed database was systematically searched for population-based prevalence studies (1930-2017). Fixed and random effects models were used for estimation of summary effect-sizes...
October 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28979010/hand-foot-and-mouth-disease-in-west-bengal-india-a-preliminary-report-on-clinicovirological-trend-over-3-successive-years-2013-2015
#20
Nilendu Sarma, Sayantani Chakraborty, Abira Dutta, Provash Chandra Sadhukhan
INTRODUCTION: Hand, foot, and mouth disease (HFMD), an enteroviral disease has emerged as a major emerging infection in India. This is caused most commonly by enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) but can also be due to CVA4-10, CVA24, CVB2-5, and echovirus 18 (Echo18). Virological analysis of the cases of HFMD has been infrequently done in India. West Bengal is one of the worst affected states in India. OBJECTIVE: To document the clinical and etiological aspect, the changing patterns and clinic-virological correlation...
September 2017: Indian Journal of Dermatology
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