keyword
https://read.qxmd.com/read/38514653/parechovirus-infection-in-human-brain-organoids-host-innate-inflammatory-response-and-not-neuro-infectivity-correlates-to-neurologic-disease
#1
JOURNAL ARTICLE
Pamela E Capendale, Inés García-Rodríguez, Anoop T Ambikan, Lance A Mulder, Josse A Depla, Eline Freeze, Gerrit Koen, Carlemi Calitz, Vikas Sood, Renata Vieira de Sá, Ujjwal Neogi, Dasja Pajkrt, Adithya Sridhar, Katja C Wolthers
Picornaviruses are a leading cause of central nervous system (CNS) infections. While genotypes such as parechovirus A3 (PeV-A3) and echovirus 11 (E11) can elicit severe neurological disease, the highly prevalent PeV-A1 is not associated with CNS disease. Here, we expand our current understanding of these differences in PeV-A CNS disease using human brain organoids and clinical isolates of the two PeV-A genotypes. Our data indicate that PeV-A1 and A3 specific differences in neurological disease are not due to infectivity of CNS cells as both viruses productively infect brain organoids with a similar cell tropism...
March 21, 2024: Nature Communications
https://read.qxmd.com/read/38488486/diversity-of-enteroviruses-in-cerebrospinal-fluid-specimens-collected-from-hospitalised-patients-in-the-private-and-public-sector-in-south-africa
#2
JOURNAL ARTICLE
Megan Janse van Rensburg, Janet Mans, Rendani T Mafuyeka, Kathy-Anne Strydom, Marcelle Myburgh, Walda B van Zyl
Enteroviruses cause a wide range of neurological illnesses such as encephalitis, meningitis, and acute flaccid paralysis. Two types of enteroviruses, echovirus E4 and E9, have recently been detected in South Africa and are known to be associated with meningitis and encephalitis. The objective of this study was to characterize enterovirus strains detected in cerebrospinal fluid specimens of hospitalized patients in the private and public sector to identify genotypes associated with meningitis and encephalitis...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38471668/environmental-surveillance-reveals-co-circulation-of-distinctive-lineages-of-enteroviruses-in-southwest-china-s-border-cities-2020-2022
#3
JOURNAL ARTICLE
Jingjing Tang, Xiaodie Zhang, Jie Zhang, Zhixian Zhao, Zhengrong Ding
AIMS: Enteroviruses are significant human pathogens associated with a range of mild to severe diseases. This study aims to understand the diversity and genetic characterization of enteroviruses circulated in southwest China's border cities by using environmental surveillance. METHODS AND RESULTS: A total of 96 sewage samples were collected in three border cities and a port located in Yunnan Province, China from July 2020 to June 2022. After cell culture and VP1 sequencing, a total of 590 enterovirus isolates were identified, belonging to 21 types...
March 1, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38458420/increased-circulation-of-echovirus-11-in-the-general-population-and-hospital-patients-as-elicited-by-the-non-polio-enterovirus-laboratory-based-sentinel-surveillance-in-northern-italy-2023
#4
JOURNAL ARTICLE
Laura Pellegrinelli, Cristina Galli, Federica Giardina, Guglielmo Ferrari, Sara Colonia Uceda Renteria, Ferruccio Ceriotti, Arlinda Seiti, Sandro Binda, Antonino Maria Guglielmo Pitrolo, Roberta Schiavo, Sergio Maria Ivano Malandrin, Annalisa Cavallero, Marco Arosio, Claudio Farina, Massimo Oggioni, Pierluigi Congedo, Danilo Cereda, Francesca Rovida, Antonio Piralla, Elena Pariani, Fausto Baldanti
OBJECTIVES: Following the alert of echovirus 11 (E-11) infection in neonates in EU/EEA Member States, we conducted an investigation of E-11 circulation by gathering data from community and hospital surveillance of enterovirus (EV) in northern Italy from August 1st , 2021 to June 30th , 2023. METHODS: Virological results of EVs were obtained from the regional sentinel surveillance database for influenza-like illness (ILI) in outpatients, and from the laboratory database of ten hospitals for inpatients with either respiratory or neurological symptoms...
March 6, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38440301/implementation-of-a-prospective-index-cluster-sampling-strategy-for-the-detection-of-presymptomatic-viral-respiratory-infection-in-undergraduate-students
#5
JOURNAL ARTICLE
Diya M Uthappa, Micah T McClain, Bradly P Nicholson, Lawrence P Park, Ilya Zhbannikov, Sunil Suchindran, Monica Jimenez, Florica J Constantine, Marshall Nichols, Daphne C Jones, Lori L Hudson, L Brett Jaggers, Timothy Veldman, Thomas W Burke, Ephraim L Tsalik, Geoffrey S Ginsburg, Christopher W Woods
BACKGROUND: Index-cluster studies may help characterize the spread of communicable infections in the presymptomatic state. We describe a prospective index-cluster sampling strategy (ICSS) to detect presymptomatic respiratory viral illness and its implementation in a college population. METHODS: We enrolled an annual cohort of first-year undergraduates who completed daily electronic symptom diaries to identify index cases (ICs) with respiratory illness. Investigators then selected 5-10 potentially exposed, asymptomatic close contacts (CCs) who were geographically co-located to follow for infections...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38439877/metatranscriptomics-revealed-the-molecular-characterization-of-circulating-enterovirus-strains-causing-aseptic-meningitis-in-children-in-wuxi-china
#6
JOURNAL ARTICLE
Ying Hua, Zhenyan Lv, Yineng Zhou, Hongxia Xiang, Mingxia Sun, Yan-Jun Kang
Enteroviruses are major etiological agents of aseptic meningitis globally, however information on circulating enterovirus types associated with this disease in Wuxi, China is limited. In this study, cerebrospinal fluid samples were collected from 20 pediatric aseptic meningitis cases in a Wuxi hospital in 2020 and subjected to metagenomic analysis to detect pathogens. Enterovirus B was detected in 9 cases, including 7 echovirus 18 (E18) and 2 echovirus 11 (E11) strains. The E18 strains exhibited 87.5-98.2% nucleotide identity and phylogenetically clustered with other China E18 strains, while the E11 strains showed 97...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38417531/the-combination-of-pleconaril-rupintrivir-and-remdesivir-efficiently-inhibits-enterovirus-infections-in-vitro-delaying-the-development-of-drug-resistant-virus-variants
#7
JOURNAL ARTICLE
Aleksandr Ianevski, Irene Trøen Frøysa, Hilde Lysvand, Carlemi Calitz, Teemu Smura, Hans-Johnny Schjelderup Nilsen, Erling Høyer, Jan Egil Afset, Adithya Sridhar, Katja C Wolthers, Eva Zusinaite, Tanel Tenson, Reet Kurg, Valentyn Oksenych, Angel S Galabov, Adelina Stoyanova, Magnar Bjørås, Denis E Kainov
Enteroviruses are a significant global health concern, causing a spectrum of diseases from the common cold to more severe conditions like hand-foot-and-mouth disease, meningitis, myocarditis, pancreatitis, and poliomyelitis. Current treatment options for these infections are limited, underscoring the urgent need for effective therapeutic strategies. To find better treatment option we analyzed efficacy of 12 known broad-spectrum anti-enterovirals both individually and in combinations against different enteroviruses in vitro...
February 26, 2024: Antiviral Research
https://read.qxmd.com/read/38399946/molecular-amplification-and-cell-culturing-efficiency-for-enteroviruses-detection-in-cerebrospinal-fluids-of-algerian-patients-suffering-from-meningitis
#8
JOURNAL ARTICLE
Abdelwahab Rai, Zohra Ammi, Dahbia Leila Anes-Boulahbal, Aymen Amin Assadi, Abdeltif Amrane, Oussama Baaloudj, Lotfi Mouni
Enteroviruses (EVs) represent a major cause of viral meningitis, being responsible for nearly 1 billion infections each year worldwide. Several techniques were developed to obtain better diagnostic results of EV infections. Herein, we evaluated the efficiency of EV detection through isolation on both Rhabdomyosarcoma (RD) and Vero cell line cultures, conventional reverse transcription-polymerase chain reaction (RT-PCR) and real-time RT-PCR. Thus, 50 cerebrospinal fluid (CSF) samples belonging to patients suspected to have viral meningitis in northern Algeria were collected, anonymously numbered from 1 to 50 and subjected to the above-mentioned techniques for EV detection...
January 23, 2024: Viruses
https://read.qxmd.com/read/38392881/echovirus-30-in-bulgaria-during-the-european-upsurge-of-the-virus-2017-2018
#9
JOURNAL ARTICLE
Irina Georgieva, Asya Stoyanova, Savina Stoitsova, Lubomira Nikolaeva-Glomb
In 2018, an increase in echovirus 30 (E30) detections was reported in some European countries. To assess the circulation and phylogenetic relationships of E30 in Bulgaria, E30 samples identified at the National Reference Laboratory for Enteroviruses, National Centre of Infectious and Parasitic Diseases, Bulgaria (NRL for Enteroviruses) in 2017 and 2018 were subjected to sequencing and phylogenetic analysis. The present study revealed that sample positivity did not significantly increase in Bulgaria during the European upsurge...
February 5, 2024: Pathogens
https://read.qxmd.com/read/38332009/genotype-f-of-echovirus-25-with-multiple-recombination-pattern-have-been-persistently-and-extensively-circulating-in-chinese-mainland
#10
JOURNAL ARTICLE
Xiaoyi Wang, Jianping Cun, Shikang Li, Yong Shi, Yingying Liu, Haiyan Wei, Yong Zhang, Ruyi Cong, Tingting Yang, Wenhui Wang, Jinbo Xiao, Yang Song, Dongmei Yan, Qian Yang, Qiang Sun, Tianjiao Ji
Echovirus 25 (E25), a member of the Enterovirus B (EV-B) species, can cause aseptic meningitis (AM), viral meningitis (VM), and acute flaccid paralysis (AFP). However, systematic studies on the molecular epidemiology of E25, especially those concerning its evolution and recombination, are lacking. In this study, 18 strains of E25, isolated from seven provinces of China between 2009 and 2018, were collected based on the Chinese hand, foot, and mouth disease (HFMD) surveillance network, and 95 sequences downloaded from GenBank were also screened...
February 8, 2024: Scientific Reports
https://read.qxmd.com/read/38316300/detection-of-echovirus-11-lineage-1-in-wastewater-samples-in-sicily
#11
JOURNAL ARTICLE
Giovanni M Giammanco, Chiara Filizzolo, Mariangela Pizzo, Giuseppa L Sanfilippo, Federica Cacioppo, Floriana Bonura, Stefano Fontana, Gabriele Buttinelli, Paola Stefanelli, Simona De Grazia
We report the presence of Echovirus 11 (E11) in wastewater in Sicily (Southern Italy), since August 2022. Overall, the 5.4 % of sewage samples (7/130) collected in 2022 were positives for E11 and then the percentage of E11-positive sewage samples reached the value of 27.27(18/66) in the first semester of 2023. Phylogenetic analysis of VP1 sequences showed for most E11-positive samples (16/25: 64 %) close genetic correlation (98.4-99.4 % nucleotide identity) to E11 lineage 1 strains involved in recently reported severe neonatal infections...
February 3, 2024: Science of the Total Environment
https://read.qxmd.com/read/38257881/brilacidin-as-a-broad-spectrum-inhibitor-of-enveloped-acutely-infectious-viruses
#12
JOURNAL ARTICLE
Carol A Anderson, Michael D Barrera, Niloufar A Boghdeh, Miata Smith, Farhang Alem, Aarthi Narayanan
Alphaviruses, belonging to the Togaviridae family, and bunyaviruses, belonging to the Paramyxoviridae family, are globally distributed and lack FDA-approved vaccines and therapeutics. The alphaviruses Venezuelan equine encephalitis virus (VEEV) and eastern equine encephalitis virus (EEEV) are known to cause severe encephalitis, whereas Sindbis virus (SINV) causes arthralgia potentially persisting for years after initial infection. The bunyavirus Rift Valley Fever virus (RVFV) can lead to blindness, liver failure, and hemorrhagic fever...
December 28, 2023: Microorganisms
https://read.qxmd.com/read/38240591/enterovirus-d68-3c-protease-antagonizes-type-i-interferon-signaling-by-cleaving-signal-transducer-and-activator-of-transcription-1
#13
JOURNAL ARTICLE
Xiaohan Li, Haoran Guo, Jiaxin Yang, Xize Liu, Huili Li, Wanying Yang, Lili Zhang, Yan Li, Wei Wei
Following the successful control of poliovirus, the re-emergence of respiratory enterovirus D68 (EV-D68), a prominent non-polio enterovirus, has become a serious public health concern worldwide. Host innate immune responses are the primary defense against EV-D68 invasion; however, the mechanism underlying viral evasion of the antiviral activity of interferons (IFN) remains unclear. In this study, we found that EV-D68 inhibited type I IFN signaling by cleaving signal transducer and activator of transcription 1 (STAT1), a crucial factor in cellular responses to interferons and other cytokines...
January 19, 2024: Journal of Virology
https://read.qxmd.com/read/38164047/novel-intertypic-recombination-of-echovirus-11-in-the-enterovirus-species-b
#14
JOURNAL ARTICLE
Yu-Nong Gong, Shu-Li Yang, Yi-Ching Chen, Yi-Chun Liu, Yhu-Chering Huang, Kuo-Chien Tsao
Enteroviruses (EVs), single-stranded, positive-sense RNA viruses, can be classified into four species (A-D), which have previously been linked to a diverse range of disease manifestations and infections affecting the central nervous system. In the Enterovirus species B (EV-B), Echovirus type 11 (E11) has been observed to occasionally circulate in Taiwan, which was responsible for an epidemic of enterovirus infections in 2018. Here, 48 clinical specimens isolated in 2003, 2004, 2009, and 2018 were collected for the high-throughput sequencing...
January 2024: Journal of Medical Virology
https://read.qxmd.com/read/38149210/optimization-of-rt-pcr-methods-for-enterovirus-detection-in-groundwater
#15
JOURNAL ARTICLE
Boeun Yoo, Mi-Gyeong Kim, A Young Min, Doo Won Seo, Seung Hwan Kim, Soon Han Kim
Enteroviruses (EVs), which belong to the Picornaviridae family, infect individuals asymptomatically or cause mild symptoms (fever, runny nose, cough, skin rash, sneezing, mouth blister). Severe cases can cause various diseases, such as acute hemorrhagic conjunctivitis, aseptic meningitis, or myocarditis, especially in infants. These viruses can be transmitted via the fecal-oral route via contaminated water. In this study, we established a polymerase chain reaction (PCR) method for detecting EVs in water sample using Coxsackievirus B5 (CV-B5) and Echovirus 30 (E-30), which belong to species B of the four species of EVs (EV-A to D)...
December 2023: Heliyon
https://read.qxmd.com/read/38128296/elongation-of-n-6-benzyladenosine-scaffold-via-pd-catalyzed-c-c-bond-formation-leads-to-derivatives-with-antiflaviviral-activity
#16
JOURNAL ARTICLE
Anastasia A Zenchenko, Mikhail S Drenichev, Evgeny V Khvatov, Victoria I Uvarova, Alexander S Goryashchenko, Vasilisa S Frolenko, Evgenia V Karpova, Liubov I Kozlovskaya, Dmitry I Osolodkin, Aydar A Ishmukhametov, Sergey N Mikhailov, Vladimir E Oslovsky
Decoration of nucleoside analogues with lipophilic groups often leads to compounds with improved antiviral activity. For example, N6 -benzyladenosine derivatives containing elongated lipophilic substituents in the benzyl core efficiently inhibit reproduction of tick-borne encephalitis virus (TBEV), while N6 -benzyladenosine itself potently inhibits reproduction of human enterovirus A71 (EV-A71). We have extended a series of N6 -benzyladenosine analogues using effective synthetic methods of CC bond formation based on Pd-catalyzed cross-coupling reactions (Sonogashira and Suzuki) in order to study the influence of bulky lipophilic substituents in the N6 position of adenosine on the antiviral activity against flaviviruses, such as TBEV, yellow fever virus (YFV) and West Nile virus (WNV), as well as a panel of enteroviruses including EV-A71, Echovirus 30 (E30), and poliovirus type 2 (PV2)...
January 15, 2024: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/38127927/shotgun-metagenomics-to-investigate-unknown-viral-etiologies-of-pediatric-meningoencephalitis
#17
JOURNAL ARTICLE
Andrea Castellot, Juan Camacho, María Dolores Fernández-García, David Tarragó
INTRODUCTION: Meningoencephalitis in children poses a diagnostic challenge, as etiology remains unknown for most of patients. Viral metagenomics by shotgun sequencing represents a powerful tool for investigating unknown viral infections related to these cases. PATIENTS AND METHODS: In a two-year, reference-centre, retrospective study, we investigated the usefulness of viral metagenomics of cerebrospinal fluid (CSF) for the diagnosis of viral infectious meningoencephalitis in forty seven pediatric patients, forty of them previously tested negative with a routine neurologic panel of viral targets that included herpesvirus 1-3 and enterovirus...
2023: PloS One
https://read.qxmd.com/read/38022906/france-reports-rise-in-severe-neonatal-infections-caused-by-a-new-enterovirus-echovirus-11-variant
#18
JOURNAL ARTICLE
Deepak Chandran, Sandip Chakraborty, Sirwan Khalid Ahmed, Hitesh Chopra, Md Rabiul Islam, Kuldeep Dhama
The surge in severe neonatal sepsis cases caused by a novel variant of Echovirus 11 (E-11) in France and several European countries has sparked concern. The affected infants, mostly premature and twins, displayed rapid clinical decline within days after birth, presenting symptoms akin to septic shock with hepatic impairment and multi-organ failure. Laboratory findings revealed profound coagulopathy, low platelet counts, and acute renal failure, indicating severe disease progression. Genetic analysis identified a distinct recombinant E-11 lineage, previously unseen in France before July 2022...
2023: Clinical pathology
https://read.qxmd.com/read/37995831/non-polio-enteroviruses-circulation-in-acute-flaccid-paralysis-cases-and-sewage-in-senegal-from-2013-to-2021
#19
JOURNAL ARTICLE
Ndack Ndiaye, Ousmane Kébé, Maryam Diarra, Fatou Diène Thiaw, Mohamed Dia, NDongo Dia, Amadou Alpha Sall, Malick Fall, Ousmane Faye, Martin Faye
BACKGROUND: Several factors can cause acute flaccid paralysis cases including non-polio enteroviruses. In Senegal, few studies on non-polio enteroviruses (NPEV) have been performed. METHODS: Our study assess the molecular epidemiology of non-polio enteroviruses in Senegal from 2013 to 2021 through the previously existing programs for surveillance of polioviruses. RESULTS: A total of 3815 stool samples and 281 sewage samples were collected...
November 21, 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/37909741/molecular-characterization-of-a-novel-clade-echovirus-3-isolated-from-patients-with-hand-foot-and-mouth-disease-in-southwest-china
#20
JOURNAL ARTICLE
Junwei Chen, Zhaoyang Chu, Ming Zhang, Yuhan Liu, Changzeng Feng, Li Li, Zhaoqing Yang, Shaohui Ma
Echovirus 3 (E3) belongs to the species Enterovirus B. Currently, three nearly whole-genome sequences of E3 are available in GenBank in China. In this study, we determined the whole genomic sequences of six E3 strains isolated from the stools of patients with hand-foot-and-mouth disease in Southwest China in 2022. Their nucleotide and amino acid sequences shared 82.1%-86.4% and 96.6%-97.2% identity with the prototype Morrisey strain, respectively, and showed 87.1% and 97.2% mutual identity. The six E3 strains are not clustered with other Chinese strains and formed a novel subgenotype (C6) with the recent American and British strains...
November 2023: Journal of Medical Virology
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