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https://www.readbyqxmd.com/read/29351651/radiotherapy-proton-beam-profilometry-with-sccvd-diamond-detector-in-single-particle-mode
#1
Marzena Rydygier, Marcin Jastrzab, Dawid Krzempek, Tomasz Nowak, Leszek Grzanka, Piotr Bednarczyk, Liliana Stolarczyk
Proton radiotherapy requires precise knowledge of the volumetric dose distribution. In proton beam delivery systems, based on narrow pencil beams, a contribution from small doses in low-intensity regions, consisting mainly of scattered protons, may have not negligible influence on total dose delivered to patient. Insufficient information about dose profile can cause underestimation of dose and potential delivery of inflated dose during hadrontherapy treatment. Presented work aims to verify applicability of diamond detectors, produced by Chemical Vapor Deposition method, for therapeutic proton beam profilometry at large fields...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29351595/propensity-matched-comparison-between-minimally-invasive-and-conventional-sternotomy-in-aortic-valve-resuspension
#2
Nadejda Monsefi, Petar Risteski, Aleksandra Miskovic, Andreas Zierer, Anton Moritz
OBJECTIVES: The aim of the study was to compare the results of David procedure through conventional or minimally invasive approach. METHODS: A propensity-matched comparison in patients undergoing a minimally invasive (partial upper sternotomy, n = 103) or complete sternotomy (n = 103) David procedure from 1991 to 2016 was performed. Patients were 57 ± 14 years old on average in both groups. The David technique was modified by generating a neosinus (P < 0...
January 16, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29351577/effects-of-excess-thromboxane-a2-on-placental-development-and-nutrient-transporters-in-a-mus-musculus-model-of-fetal-growth-restriction
#3
Karen J Gibbins, Katherine N Gibson-Corley, Ashley S Brown, Matthew Wieben, Richard C Law, Camille M Fung
Hypertensive disease of pregnancy (HDP) with placental insufficiency is the most common cause of fetal growth restriction (FGR) in the developed world. Despite the known negative consequences of HDP both to the mother and fetus, little is known about the longitudinal placental changes that occur as HDP progresses in pregnancy. This is because longitudinal sampling of human placentae during each gestation is impossible. Therefore, using a mouse model of thromboxane A2-analog infusion to mimic human HDP in the last trimester, we calculated placental efficiencies based on fetal and placental weights, quantified spongiotrophoblast and labyrinth thicknesses and vascular density within these layers, examined whether hypoxia signaling pathway involving vascular endothelial growth factor A (VEGFA) and its receptors (VEGFR1, VEGFR2) and matrix metalloproteinases (MMPs) contributed to vascular change, and examined nutrient transporter abundance including glucose transporters 1 and 3 (GLUT1, GLUT3), neutral amino acid transporters 1, 2, and 4 (SNAT1, SNAT2, and SNAT4), fatty acid transporters 2 and 4 (FATP2, FATP4) and fatty acid translocase (CD36) from embryonic day 15...
January 17, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29351306/an-approach-to-localization-for-ensemble-based-data-assimilation
#4
Bin Wang, Juanjuan Liu, Li Liu, Shiming Xu, Wenyu Huang
Localization techniques are commonly used in ensemble-based data assimilation (e.g., the Ensemble Kalman Filter (EnKF) method) because of insufficient ensemble samples. They can effectively ameliorate the spurious long-range correlations between the background and observations. However, localization is very expensive when the problem to be solved is of high dimension (say 106 or higher) for assimilating observations simultaneously. To reduce the cost of localization for high-dimension problems, an approach is proposed in this paper, which approximately expands the correlation function of the localization matrix using a limited number of principal eigenvectors so that the Schür product between the localization matrix and a high-dimension covariance matrix is reduced to the sum of a series of Schür products between two simple vectors...
2018: PloS One
https://www.readbyqxmd.com/read/29351220/assessment-of-validity-and-reproducibility-of-the-zinc-specific-dietary-intake-questionnaire-conducted-for-young-polish-female-respondents
#5
Dominika Głąbska, Aleksandra Staniec, Dominika Guzek
One of the brief methods enabling the assessment of the zinc intake and identification of individuals characterized by insufficient zinc intake, is zinc-specific food frequency questionnaire. The aim of the study was to assess the validity and reproducibility of the elaborated zinc-specific food frequency questionnaire ZINC-FFQ (Zinc INtake Calculation-Food Frequency Questionnaire) in a group of young Polish female respondents. The validity was assessed in comparison with 3-day dietary records, while reproducibility was assessed for the ZINC-FFQ filled in twice (FFQ1 and FFQ2-six weeks apart)...
January 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29351180/one-stage-vs-two-stage-repair-of-asymmetric-bilateral-cleft-lip-a-20-year-retrospective-study-of-clinical-outcome
#6
KyungHoon Chung, Lun-Jou Lo
BACKGROUND: The one-stage or two-stage approaches have been a widely used technique for patients with an asymmetric bilateral cleft lip (ABCL). There is insufficient long-term outcome data between these two methods. The purpose of this retrospective study is to compare the clinical outcome over the last 20 years. METHODS: The senior author's database was searched for patients with ABCL from 1995 to 2015. Qualified patients were divided into two groups: one-stage vs...
January 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29351138/the-effect-of-melatonin-upon-postacute-withdrawal-among-males-in-a-residential-treatment-program-m-paws-a-randomized-double-blind-placebo-controlled-trial
#7
Corry D Bondi, Khalid M Kamal, David A Johnson, Paula A Witt-Enderby, Vincent J Giannetti
OBJECTIVE: Assess the effect of melatonin (5 mg) compared with placebo as an adjuvant treatment along with current behavioral and pharmacotherapy for 28 days on weekly self-reported severity of anxiety, depression, stress, and sleep complaints, and also how sleep is affecting daily life in males 18 years of age and older in recovery from substance use at a residential program in south-western Pennsylvania. BACKGROUND: Individuals in recovery experience a variety of symptoms including, but are not limited to, anxiety, depression, sleep difficulties, and stress...
January 18, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29351104/frequency-of-blood-pressure-and-estimated-glomerular-filtration-rate-monitoring-in-patients-affected-by-hypertension-a-retrospective-study-with-176%C3%A2-565-patients-in-germany
#8
Louis Jacob, Florian Seitz, Karel Kostev
OBJECTIVE: The aim of this study was to analyze the frequency of blood pressure (BP) and estimated glomerular filtration rate (eGFR) monitoring in hypertension patients followed in primary care practices in Germany. PATIENTS AND METHODS: This study included patients who had received at least two hypertension diagnoses (ICD-10: I10) in 2016. The primary outcome of this study was the frequency of BP and eGFR monitoring in patients with hypertension in the year 2016...
January 18, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29350873/test-procedures-to-assess-somatosensory-abnormalities-in-individuals-with-peripheral-joint-pain-a-systematic-review-of-psychometric-properties
#9
REVIEW
Abdullah Alqarni, Donald Manlapaz, David Baxter, Steve Tumilty, Ramakrishnan Mani
BACKGROUND: Test procedures that were developed to assess somatosensory abnormalities should possess optimal psychometric properties (PMPs) to be used in clinical practice. The aim of this systematic review is to evaluate the literature to assess the level of evidence for PMPs of test procedures investigated in individuals with peripheral joint pain (PJP). METHODS: A comprehensive electronic literature search was conducted in seven databases from inception to March 2016...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29350708/sleep-wake-disturbance-a-systematic-review-of-evidence-based-interventions-for-management-in-patients-with-cancer
#10
Ellyn Matthews, Patricia Carter, Margaretta Page, Grace Dean, Ann Berger
BACKGROUND: New or worsening sleep-wake disturbance (SWD) can occur throughout the cancer trajectory.
. OBJECTIVES: The purpose of this article is to critically review available empirical evidence supporting the efficacy of interventions for SWD, highlighting new evidence since the 2006 and 2009 Putting Evidence Into Practice (PEP) SWD publications.
. METHODS: A systematic review of studies published from 2009-2017 was conducted to identify effective interventions for cancer-related SWD...
February 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29350667/the-schmidt-syndrome
#11
Carmine Siniscalchi, Valentina Moretti, Simona Cataldo, Anna Rocci, Manuela Basaglia, Maria Ilaria Tassoni, Roberto Quintavalla
Addison's disease (AD) is a rare endocrine condition related to adrenal insufficiency. Autoimmune adrenalitis is commonly associated with autoimmune diseases. Autoimmune Addison's Disease (AAD) describes Autoimmune Polyendocrine Syndrome (APS) in 60% of patients with an important immunitary pathogenesis imprinting. We describes a case of Autoimmune Polyendocrine Syndrome charachterize by adrenal insufficiency and thyroid disease (Schmidt Syndrome). In this case report, Addison's disease had a slow onset in absence of the typical weight loss...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350393/is-it-possible-to-improve-compliance-in-hypertension-and-reduce-therapeutic-inertia-of-physicians-by-mandatory-periodical-examinations-of-workers
#12
Andrzej Marcinkiewicz, Michał Plewka, Wojciech Hanke, Paweł Kałużny, Marta Wiszniewska, Agnieszka Lipińska-Ojrzanowska, Jolanta Walusiak-Skorupa
BACKGROUND: Due to high prevalence, insufficient recognition and ineffectual treatment, hypertension (HT) still remains a major medical and socio-economic problem. There is a real necessity to develop effective prophylaxis for cardiovascular disorders (CVD), based on strategies which support compliance during long-term therapy. The Polish scheme of occupational health services (OHS) with mandatory periodical employee check-ups creates a unique opportunity for effective HT prophylaxis...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350371/fundus-first-technique-and-partial-cholecystectomy-for-difficult-laparoscopic-cholecystectomies
#13
İsmail Cem Sormaz, Yiğit Soytaş, Ali Fuat Kaan Gök, İlker Özgür, Levent Avtan
BACKGROUND: This study aims to evaluate the impact of conversion from retrograde dissection to fundus-first technique (FF) or laparoscopic partial cholecystectomy (LPC) on complication rates, operation time, and duration of hospitalization. METHODS: The medical records of 210 consecutive patients who underwent laparoscopic cholecystectomy between January 2010 and December 2014 were retrospectively evaluated. All laparoscopic cholecystectomies were initiated with retrograde dissection (RD)...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350350/biochemical-changes-and-clinical-outcomes-in-34-patients-with-classic-galactosemia
#14
Tatiana Yuzyuk, Krista Viau, Ashley Andrews, Marzia Pasquali, Nicola Longo
Impaired activity of galactose-1-phosphate uridyltransferase (GALT) causes galactosemia, an autosomal recessive disorder of galactose metabolism. Early initiation of a galactose-restricted diet can prevent or resolve neonatal complications. Despite therapy, patients often experience long-term complications including speech impairment, learning disabilities, and premature ovarian insufficiency in females. This study evaluates clinical outcomes in 34 galactosemia patients with markedly reduced GALT activity and compares outcomes between patients with different levels of mean galactose-1-phosphate in red blood cells (GAL1P) using logistic regression: group 1 (n = 13) GAL1P ≤1...
January 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29350254/sacubitril-valsartan-for-heart-failure-with-reduced-left-ventricular-ejection-fraction-a%C3%A2-retrospective-cohort-study
#15
R De Vecchis, C Ariano, G Di Biase, M Noutsias
BACKGROUND: The combination drug sacubitril/valsartan was reported to be superior to enalapril in reducing all-cause death, cardiovascular mortality, and heart failure (HF) hospitalizations in patients with cardiac insufficiency and reduced left ventricular ejection fraction (HFREF) with NYHA class II-IV. METHODS: Our retrospective cohort study aimed to assess the effects of sacubitril/valsartan in addition to a beta-blocker and mineral receptor antagonist (MRA) in a group of HFREF patients with NYHA class II-III HF vs...
January 19, 2018: Herz
https://www.readbyqxmd.com/read/29350249/efficacy-of-phloroglucinol-for-treatment-of-abdominal-pain-a-systematic-review-of-literature-and-meta-analysis-of-randomised-controlled-trials-versus-placebo
#16
REVIEW
Clara Blanchard, Denis Pouchain, Paul Vanderkam, Marie-Christine Perault-Pochat, Rémy Boussageon, Hélène Vaillant-Roussel
AIM: Phloroglucinol is a musculotropic anti-spasmodic drug. It is frequently prescribed in many European countries with a considerable cost for health services. The purpose of this study was to review the existing randomised controlled trials (RCT) comparing the efficacy of phloroglucinol treating abdominal pain versus placebo. METHODS: A literature search was carried out up to May 2017 to select RCT comparing the effect of phloroglucinol versus placebo with intensity of abdominal pain as an endpoint...
January 19, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29350111/sustained-viral-suppression-with-co-administration-of-oxcarbazepine-and-dolutegravir
#17
Manar M Kandil, Melissa E Badowski, Christopher A Schriever
Co-administration of dolutegravir and oxcarbazepine has been reported to reduce levels of dolutegravir and therefore is contraindicated due to insufficient data to make dosing recommendations. We present eight cases in which patients with human immunodeficiency virus (HIV) inadvertently received oxcarbazepine while concurrently receiving 50 mg of dolutegravir daily as part of their antiretroviral therapy. Upon further evaluation, lab results revealed that despite the risk of decreased levels of dolutegravir due to possible oxcarbazepine enzyme induction, patients maintained at or near virologic suppression (viral load <20 copies/ml)...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29350009/-etiological-analysis-preventional-and-therapeutical-strategies-for-the-unsatisfied-cervical-posterior-decompression-surgery
#18
De-An Qin, Xiao-Guang Liu, Feng-Liang Wu, Zhong-Jun Liu, Feng-Shan Zhang, Yu Sun
OBJECTIVE: To discuss the causes of unsatisfied cervical posterior decompression surgery and describe the overhauling strategies and precaution. METHODS: The clinical data of 14 patients required revision surgery were retrospectively analyzed, and these patients with unsatisfied effects were due to cervical posterior decompression surgery from January 2012 to December 2014. Overhauling reasons were analyzed and then different revision procedures were performed. The functions of cervical cord and ambulation were evaluated respectively by modified Japanese Orthopedic Association(mJOA) score and Nurick grade according to the course order:preoperative for the first time, pre-revision and at final follow-up...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349937/changes-in-clinical-characteristics-of-patients-with-an-initial-diagnosis-of-prostate-cancer-in-korea-10-year-trends-reported-by-a-tertiary-center
#19
Ji Eun Heo, Hyun Kyu Ahn, Jinu Kim, Byung Ha Chung, Kwang Suk Lee
BACKGROUND: The Korea Central Cancer Registry reported that incidence rates of prostate cancer have not increased continuously. We used recent trends in the incidence of prostate cancer to generate a preliminary report of the Korean population with prostate cancer. METHODS: Patients initially diagnosed with prostate cancer by prostate biopsy from 2006 to 2015 at our tertiary center were selected. All patients were categorized according to age (< 65, 65-75, > 75 years), time period (2006-2010 vs...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349730/ccn5-in-alveolar-epithelial-proliferation-and-differentiation-during-neonatal-lung-oxygen-injury
#20
Najla Fiaturi, Joshua W Russo, Heber C Nielsen, John J Castellot
Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks of gestation. These infants are at high risk of developing respiratory distress syndrome (RDS), a lung disease caused by insufficient surfactant production and immaturity of saccular/alveolar type II epithelial cells in the lung. RDS treatment includes oxygen and respiratory support that improve survival but also increase the risk for bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by arrested alveolarization, airway hyperreactivity, and pulmonary hypertension...
January 18, 2018: Journal of Cell Communication and Signaling
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