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https://www.readbyqxmd.com/read/27622346/effects-of-clostridium-butyricum-and-bifidobacterium-on-btla-expression-on-cd4-t-cells-and-lymphocyte-differentiation-in-late-preterm-infants
#1
Shi-Fa Zhang, Zong-Sheng Tang, Ling Tong, Xiang-Xiang Tao, Qi-Feng Suo, Xue-Mei Xu
BACKGROUND & AIMS: Probiotics is recognized to promote growth performance and immune function via balancing the intestinal microflora. Live clostridium butyricum and bifidobacterium combined powder (LCBBCP) has been widely to treat intestinal dysbacteriosis in newborns in China. This study was undertaken to investigate the effects of the combined probiotics on the expression of B and T lymphocyte attenuator (BTLA) on CD4(+) T cells and the differentiation of lymphocyte subsets in late preterm infants...
September 10, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/26125762/well-balanced-commensal-microbiota-contributes-to-anti-cancer-response-in-a-lung-cancer-mouse-model
#2
Q-F Gui, H-F Lu, C-X Zhang, Z-R Xu, Y-H Yang
The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising the question of whether the microflora affects inflammatory processes that contribute to cancer and its therapy. Prebiotics have also been found to play an antitumor role that is not limited to the gut. We investigated the antitumor roles of the intestinal microbiota using the Lewis lung cancer mouse model. In mice treated with cisplatin combined with ABX (an antibiotic cocktail of vancomycin, ampicillin, and neomycin), which can destroy the host commensal microflora, the tumor size was larger than in mice on a single treatment of cisplatin...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/24452018/acquisition-of-innate-like-microbial-reactivity-in-mucosal-tissues-during-human-fetal-mait-cell-development
#3
Edwin Leeansyah, Liyen Loh, Douglas F Nixon, Johan K Sandberg
Innate-like, evolutionarily conserved MR1-restricted mucosa-associated invariant T (MAIT) cells represent a large antimicrobial T-cell subset in humans. Here, we investigate the development of these cells in second trimester human fetal tissues. MAIT cells are rare and immature in the fetal thymus, spleen and mesenteric lymph nodes. In contrast, mature IL-18Rα(+) CD8αα MAIT cells are enriched in the fetal small intestine, liver and lung. Independently of localization, MAIT cells express CD127 and Ki67 in vivo and readily proliferate in response to Escherichia coli in vitro...
2014: Nature Communications
https://www.readbyqxmd.com/read/23263901/probiotic-lactobacillus-rhamnosus-gg-modulates-the-mucosal-immune-response-in-giardia-intestinalis-infected-balb-c-mice
#4
Nisha Goyal, Geeta Shukla
BACKGROUND: Gut homeostasis can be altered by the oral administration of health-promoting microorganisms, namely probiotics that are known to reinforce the host immune response. AIM: The aim of this study was to elucidate the immunomodulatory effect of orally administered probiotic Lactobacillus rhamnosus GG (LGG) in Giardia-infected mice. METHODS: BALB/c mice were fed orally with probiotic LGG either 7 days prior to or simultaneously with the challenge dose of Giardia trophozoites...
May 2013: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/22826710/erythromycin-treatment-hinders-the-induction-of-oral-tolerance-to-fed-ovalbumin
#5
Sydney E Lambert, Jeremy M Kinder, Jenny E Then, Kelly N Parliament, Heather A Bruns
The mucosal immune system is constantly exposed to antigen, whether it be food antigen, commensal bacteria, or harmful antigen. It is essential that the mucosal immune system can distinguish between harmful and non-harmful antigens, and initiate an active immune response to clear the harmful antigens, while initiating a suppressive immune response (tolerance) to non-harmful antigens. Oral tolerance is an immunologic hyporesponsiveness to an orally administered antigen and is important in preventing unnecessary gastrointestinal tract inflammation, which can result in a number of autoimmune and hypersensitivity diseases...
2012: Frontiers in Immunology
https://www.readbyqxmd.com/read/22698680/pathological-effect-of-il-17a-producing-tcr%C3%AE-%C3%AE-t-cells-in-mouse-genital-mucosa-against-hsv-2-infection
#6
Jae-Ouk Kim, Hye-Ran Cha, Eun-Do Kim, Mi-Na Kweon
Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mRNA levels of IL-17A and RORγt were determined in TCRγδ(+) T cells isolated from mouse genital tract but lacked detectable expression of IFNγ, T-bet, and FoxP3. IL-17A production by genital TCRγδ(+) T cells was maintained after intravaginal vaccination with cholera toxin or avirulent herpes simplex virus type (HSV)-2 186 syn ΔTK strain...
September 2012: Immunology Letters
https://www.readbyqxmd.com/read/22384106/interleukin-7-links-t-lymphocyte-and-intestinal-epithelial-cell-homeostasis
#7
Shabnam Shalapour, Katrin Deiser, Anja A Kühl, Rainer Glauben, Susanne M Krug, André Fischer, Ozen Sercan, Stephane Chappaz, Stefan Bereswill, Markus M Heimesaat, Christoph Loddenkemper, Michael Fromm, Daniela Finke, Günter J Hämmerling, Bernd Arnold, Britta Siegmund, Thomas Schüler
Interleukin-7 (IL-7) is a major survival factor for mature T cells. Therefore, the degree of IL-7 availability determines the size of the peripheral T cell pool and regulates T cell homeostasis. Here we provide evidence that IL-7 also regulates the homeostasis of intestinal epithelial cells (IEC), colon function and the composition of the commensal microflora. In the colon of T cell-deficient, lymphopenic mice, IL-7-producing IEC accumulate. IEC hyperplasia can be blocked by IL-7-consuming T cells or the inactivation of the IL-7/IL-7R signaling pathway...
2012: PloS One
https://www.readbyqxmd.com/read/22151521/identification-of-immune-cells-by-flow-cytometry-in-vaginal-lavages-from-women-with-vulvovaginitis-and-normal-microflora
#8
Paulo César Giraldo, Joziani Beghini Junqueira de Carvalho, Rose Luce Gomes do Amaral, Ana Katherine da Silveira Gonçalves, José Eleutério, Fernando Guimarães
PROBLEM:   The extent of the vaginal immune response is not fully determined. The purpose of this study was to evaluate the vaginal immune cells from women with vulvovaginitis (VV). METHOD OF STUDY: A total of 142 volunteers diagnosed with bacterial vaginosis (BV), vulvovaginal candidiasis (VC), and BV associated with VC or normal microflora were sampled to evaluate the immune cells by flow cytometry. The immune cells were obtained by vaginal lavage and labeled with fluorochrome-conjugated monoclonal antibodies to identify neutrophil granulocytes, macrophages, CD4(+) and CD8(+) T lymphocytes, B lymphocytes, and NK lymphocytes...
March 2012: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/21947722/protective-effect-of-probiotics-on-intestinal-barrier-function-in-malnourished-rats-after-liver-transplantation
#9
Zhi-Gang Ren, Hui Liu, Jian-Wen Jiang, Li Jiang, Hui Chen, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng
BACKGROUND: Most patients waiting for liver transplantation have end-stage liver diseases with malnutrition, which is prone to induce intestinal barrier dysfunction after liver transplantation. We aimed to study the effect of probiotics on intestinal barrier function in malnourished rats following liver transplantation with long-term antibiotics. METHODS: Twelve Lewis rats were selected as donors. Twelve BN rats, which served as recipients, were subjected to malnutrition by semi-starvation for 4-5 weeks...
October 2011: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/21917242/age-related-changes-in-the-distribution-and-frequency-of-myeloid-and-t-cell-populations-in-the-small-intestine-of-calves
#10
Patrick N Fries, Yurij I Popowych, Le Luo Guan, Philip J Griebel
Mucosal dendritic cells (DCs) play a key role in discriminating between dietary antigens, commensal microflora and pathogens but little is known regarding age-related changes in mucosal DC populations. We analyzed lymphoid and myeloid populations within the epithelium and lamina propria (LP) of the ileum and jejunum of weaned calves (6 months old) and compared their frequency and distribution with newborn calves (3-5 weeks old). CD4, CD8 and γδ TcR T cells and CD11c(Hi)MHC Class II(+) myeloid cell frequency were significantly different when comparing ileum and jejunum of weaned calves...
2011: Cellular Immunology
https://www.readbyqxmd.com/read/21767856/leukocytic-responses-and-intestinal-mucin-dynamics-of-broilers-protected-with-enterococcus-faecium-ef55-and-challenged-with-salmonella-enteritidis
#11
Martin Levkut, Viera Revajová, Andrea Lauková, Zuzana Ševčíková, Viera Spišáková, Zita Faixová, Mária Levkutová, Viola Strompfová, Juraj Pistl, Mikuláš Levkut
The protective effect of Enterococcus faecium EF55 in chickens challenged with Salmonella enterica serovar Enteritidis phage type 4 (SE PT4) was assessed. The antibacterial effect on the bacterial microflora in the small intestine in relation to white blood cell count, phenotyping of peripheral blood and intestinal lymphocytes, functional activity of lymphocytes and phagocytes and mucin quantitation were investigated. Day-old chicks (85) were randomly divided into four groups. The probiotic group (EF) and Salmonella+probiotic group (EFSE) received E...
August 2012: Research in Veterinary Science
https://www.readbyqxmd.com/read/21446172/-immunological-and-bacteriological-monitoring-of-patients-with-pneumonia-and-influenza-a-h1n1-infection
#12
K G Shapovalov, T E Belokrinitskaia, Zh S Burdinskaia, A V Maliarchikov
AIM: To study features of immune status and causative agents of severe pneumonia in patients with influenza A/H1N1. MATERIALS AND METHODS: Fifty-seven isolates from 43 patients with pneumonia, which complicated pandemic influenza A/ H1N1 and treated in Chita city clinical hospital No.1 as well as 32 immunograms were retrospectively studied. Comparison of immunologic and epidemiologic status of patients with influenza A/ H1N1 complicated by pneumonia was performed...
January 2011: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
https://www.readbyqxmd.com/read/20954806/fermentation-metabolites-from-lactobacillus-gasseri-and-propionibacterium-freudenreichii-exert-bacteriocidal-effects-in-mice
#13
COMPARATIVE STUDY
Yuko Kato-Mori, Takenori Orihashi, Yuta Kanai, Michiko Sato, Kenji Sera, Katsuro Hagiwara
Lactobacillus gasseri OLL 2716 promotes the elimination of Helicobacter pylori and is utilized in yogurts that are specifically labeled as health foods. On the other hand, milk whey fermented by Propionibacterium freudenreichii ET-3, which increases the numbers of Bifidobacterium, is effective for intestinal disorders. We previously demonstrated that oral administration of L. gasseri and P. freudenreichii fermentation metabolites (LP-FM) improved calf intestinal microflora and reduced the incidence of diarrhea...
December 2010: Journal of Medicinal Food
https://www.readbyqxmd.com/read/20860856/diet-exercise-and-gut-mucosal-immunity
#14
REVIEW
Roxana Valdés-Ramos, Beatriz E Martínez-Carrillo, Irma I Aranda-González, Ana Laura Guadarrama, Rosa Virgen Pardo-Morales, Patricia Tlatempa, Rosa A Jarillo-Luna
Diet and exercise are primary strategies recommended for the control of the obesity epidemic. Considerable attention is being paid to the effect of both on the immune system. However, little research has been done on the effect of diet, nutrients or exercise on the mucosal immune system. The gastrointestinal tract (gut) is not only responsible for the entry of nutrients into the organism, but also for triggering the primary immune response to orally ingested antigens. The gut-associated lymphoid tissue contains a large amount of immune cells, disseminated all along the intestine in Peyer's patches and lamina propria...
November 2010: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/20452828/epithelial-specific-blockade-of-myd88-dependent-pathway-causes-spontaneous-small-intestinal-inflammation
#15
Jianfeng Gong, Jingyue Xu, Weiming Zhu, Xiang Gao, Ning Li, Jieshou Li
Accumulating evidence suggests a role for Toll-like receptor (TLR) signaling at the intestinal epithelial cells (IECs) level for intestinal protection against exogenous injury or pathogenic infection. We hypothesized that MyD88 dependent TLR signaling at intestinal epithelium is critical for mucosal immune homeostasis. In the current study, a transgenic mouse model was generated in which a dominant-negative mutant of MyD88 (dnMyD88) was driven by an intestinal epithelial-specific murine villin promoter. Aged transgenic mice spontaneously developed chronic small intestinal inflammation, as revealed by increased CD4+ and CD8+ lymphocytes, neutrophil and macrophage infiltration, increased production of cytokines as TNF-alpha, IFN-gamma, IL-1beta, and IL-17, crypt abscesses, lymphedema, and Goblet cell depletion...
August 2010: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/19395514/effects-of-yeast-culture-supplementation-on-growth-performance-intestinal-health-and-immune-response-of-nursery-pigs
#16
RANDOMIZED CONTROLLED TRIAL
Y B Shen, X S Piao, S W Kim, L Wang, P Liu, I Yoon, Y G Zhen
A total of 216 weaning pigs were used in 2 experiments to determine the effects of dietary supplementation of yeast culture (YC) at different dose levels on the growth performance, nutrient digestibility, intestinal morphology, intestinal microflora, and immune response in weanling pigs and to determine whether YC can be a candidate to replace antibiotic growth promoters (AGP). In Exp. 1, 192 pigs (7.5 +/- 0.2 kg of BW) weaned at 28 d of age were randomly allotted to 6 treatments: 1) control (without AGP or YC); 2) AGP (chlortetracycline, 80 mg/kg); 3) 2...
August 2009: Journal of Animal Science
https://www.readbyqxmd.com/read/18835196/commensal-dna-limits-regulatory-t-cell-conversion-and-is-a-natural-adjuvant-of-intestinal-immune-responses
#17
Jason A Hall, Nicolas Bouladoux, Cheng Ming Sun, Elizabeth A Wohlfert, Rebecca B Blank, Qing Zhu, Michael E Grigg, Jay A Berzofsky, Yasmine Belkaid
The intestinal tract is in intimate contact with the commensal microflora. Nevertheless, how commensals communicate with cells to ensure immune homeostasis is still unclear. In this study, we found that gut flora DNA (gfDNA) plays a major role in intestinal homeostasis through Toll-like receptor 9 (TLR9) engagement. Tlr9(-/-) mice displayed increased frequencies of CD4(+)Foxp3(+) regulatory T (Treg) cells within intestinal effector sites and reduced constitutive IL-17- and IFN-gamma-producing effector T (Teff) cells...
October 17, 2008: Immunity
https://www.readbyqxmd.com/read/18759154/involvement-of-central-immunity-in-uncomplicated-diverticular-disease
#18
Rossella Cianci, Federico Iacopini, Lucio Petruzziello, Giovanni Cammarota, Franco Pandolfi, Guido Costamagna
OBJECTIVE: The pathogenesis of symptoms of uncomplicated diverticular disease (UDD) is unclear, but changes in gut microflora and physiologic inflammation may be implicated. The objective of the study was to investigate the distribution of gut homing lymphocytes in peripheral blood and intestinal mucosa of UDD patients, and the effects of luminal antibiotic treatment. MATERIAL AND METHODS: Ten UDD patients and 10 age- and gender-matched healthy subjects underwent peripheral blood sampling, and colonoscopy with biopsies taken from the transverse and sigmoid colon...
2009: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/18420983/detection-of-t-lymphocytes-in-intestine-of-broiler-chicks-treated-with-lactobacillus-spp-and-challenged-with-salmonella-enterica-serovar-enteritidis
#19
RANDOMIZED CONTROLLED TRIAL
J C Noujaim, R L Andreatti Filho, E T Lima, A S Okamoto, R L Amorim, R Torres Neto
The expression of immune response in the form of leukocytic infiltrate by CD3+, CD4+, and CD8+ cells in the epithelium and in the intestinal lamina propria of chicks was studied in the present work by means of immunohistochemical reaction. The chicks were treated with Lactobacillus spp. or cecal microflora (CM) and experimentally challenged or not with Salmonella enterica serovar Enteritidis. The 320 birds utilized were divided into 4 groups containing 80 chicks each and submitted to treatments with Lactobacillus reuteri, Lactobacillus salivarius, Lactobacillus acidophilus, and CM...
May 2008: Poultry Science
https://www.readbyqxmd.com/read/17870185/influence-of-the-probiotic-bacillus-cereus-var-toyoi-on-the-intestinal-immunity-of-piglets
#20
RANDOMIZED CONTROLLED TRIAL
L Scharek, B J Altherr, C Tölke, M F G Schmidt
In a feeding trial, sows and piglets were fed with the probiotic bacterium Bacillus cereus var. toyoi as a feed additive, and the effects on immune cell populations were examined. The development of the gut immune system was determined for piglets at the ages of 14, 28, 35 and 56 days post partum. Tissue samples of the Jejunum and the continuous Peyer's patch were used for enumeration of intraepithelial lymphocyte populations by fluorescence activated flow cytometry and fluorescence microscopy. Both independent methods of investigation led to similar results: the population of intraepithelial CD8+ T cells was significantly enhanced in the probiotic group piglets (p< or =0...
December 15, 2007: Veterinary Immunology and Immunopathology
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