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Integrated medicine

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https://www.readbyqxmd.com/read/28454110/personalizing-chinese-medicine-by-integrating-molecular-features-of-diseases-and-herb-ingredient-information-application-to-acute-myeloid-leukemia
#1
REVIEW
Lin Huang, Haichang Li, Duoli Xie, Tieliu Shi, Chengping Wen
Traditional Chinese Medicine (TCM) has been widely used as a complementary medicine in Acute Myeloid Leukemia (AML) treatment. In this study, we proposed a new classification of Chinese Medicines (CMs) by integrating the latest discoveries in disease molecular mechanisms and traditional medicine theory. We screened out a set of chemical compounds on basis of AML differential expression genes and chemical-protein interactions and then mapped them to Traditional Chinese Medicine Integrated Database. 415 CMs contain those compounds and they were categorized into 8 groups according to the Traditional Chinese Pharmacology...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453916/digital-technology-and-clinical-decision-making-in-depression-treatment-current-findings-and-future-opportunities
#2
REVIEW
Kevin A Hallgren, Amy M Bauer, David C Atkins
Clinical decision making encompasses a broad set of processes that contribute to the effectiveness of depression treatments. There is emerging interest in using digital technologies to support effective and efficient clinical decision making. In this paper, we provide "snapshots" of research and current directions on ways that digital technologies can support clinical decision making in depression treatment. Practical facets of clinical decision making are reviewed, then research, design, and implementation opportunities where technology can potentially enhance clinical decision making are outlined...
April 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28453650/plantismash-automated-identification-annotation-and-expression-analysis-of-plant-biosynthetic-gene-clusters
#3
Satria A Kautsar, Hernando G Suarez Duran, Kai Blin, Anne Osbourn, Marnix H Medema
Plant specialized metabolites are chemically highly diverse, play key roles in host-microbe interactions, have important nutritional value in crops and are frequently applied as medicines. It has recently become clear that plant biosynthetic pathway-encoding genes are sometimes densely clustered in specific genomic loci: biosynthetic gene clusters (BGCs). Here, we introduce plantiSMASH, a versatile online analysis platform that automates the identification of candidate plant BGCs. Moreover, it allows integration of transcriptomic data to prioritize candidate BGCs based on the coexpression patterns of predicted biosynthetic enzyme-coding genes, and facilitates comparative genomic analysis to study the evolutionary conservation of each cluster...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28453319/does-a-checklist-reduce-the-number-of-errors-made-in-nurse-assembled-discharge-prescriptions
#4
Corrine Byrne, Hannah Sierra, Rowan Tolhurst
BACKGROUND: The safe supply of medicines is an integral part of being discharged from hospital. Locally, nurses are responsible for assembling medication for discharge prescriptions. Over a 2-year period 15 serious medication errors relating to discharge were reported on the health and ageing unit. This project was designed to evaluate whether a discharge medication checklist could reduce errors on nurse-assembled discharge prescriptions. METHODS AND RESULTS: A baseline audit was conducted to identify the number of medication errors on nurse-assembled discharge prescriptions...
April 27, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28453275/dielectric-response-of-cytoplasmic-water-and-its-connection-to-the-vitality-of-human-red-blood-cells-ii-the-influence-of-storage
#5
Evgeniya Levy, Marcelo David, Gregory Barshtein, Saul Yedgar, Leonid Livshits, Paul Ben Ishai, Yuri Feldman
Maintaining an appropriate inventory of packaged blood products is a critical part of modern medicine. Consequently, the assessment of red blood cell (RBC) functionality is instrumental for the monitoring of the quality of stored RBC (sRBC) in the blood bank. We present a comprehensive study of sRBC lesion kinetics in SAGM (Saline, Adenine, Glucose, Mannitol) solution, using microwave dielectric spectroscopy (0.5 GHz - 50 GHz) and cell deformability. As part of the research we have isolated the microwave dielectric response of cytoplasmic water in sRBC...
April 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28448782/amcp-partnership-forum-driving-value-and-outcomes-in-oncology
#6
(no author information available yet)
Innovation in cancer treatment has provided a wealth of recently available therapeutic agents and a healthy drug pipeline that promises to change the way we approach this disease and the lives of those affected in the years to come. However, the majority of these new agents, many of which are targeted to specific genomic features of various tumors, may challenge the health care system's ability to afford cancer care. This innovation drives the need to focus on the value of the treatments provided to patients with cancer and on methods to optimize the efficiency of the dollars we spend, in addition to the clinical value itself...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448775/exploring-electronic-medical-record-and-self-administered-medication-risk-screening-tools-in-a-primary-care-clinic
#7
Mark J Makowsky, Ken Cor, Tat Wong
BACKGROUND: Electronic medical record (EMR) screening for indicators of medication risk could improve efficiency in identifying primary care clinic patients in need of clinical pharmacist care compared with patient self-reporting. OBJECTIVES: To (a) compare the performance of an EMR medication risk assessment questionnaire (MRAQ) with a self-administered (SA) MRAQ and (b) explore each tool's ability to predict indicators of health behavior, health status, and health care utilization...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28447035/novel-therapeutic-approaches-rett-syndrome-and-human-induced-pluripotent-stem-cell-technology
#8
REVIEW
Mohan Gomathi, Vellingiri Balachandar
Recent advances in induced pluripotent stem cell (iPSC) technology target screening and discovering of therapeutic agents for the possible cure of human diseases. Human induced pluripotent stem cells (hiPSC) are the right kind of platform for testing potency of specific active compounds. Ayurveda, the Indian traditional system of medicine developed between 2,500 and 500 BC, is a science involving the intelligent formulations of herbs and minerals. It can serve as a "goldmine" for novel neuroprotective agents used for centuries to treat neurological disorders...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28444778/development-and-implementation-of-an-84-channel-matrix-gradient-coil
#9
Sebastian Littin, Feng Jia, Kelvin J Layton, Stefan Kroboth, Huijun Yu, Jürgen Hennig, Maxim Zaitsev
PURPOSE: Design, implement, integrate, and characterize a customized coil system that allows for generating spatial encoding magnetic fields (SEMs) in a highly-flexible fashion. METHODS: A gradient coil with a high number of individual elements was designed. Dimensions of the coil were chosen to mimic a whole-body gradient system, scaled down to a head insert. Mechanical shape and wire layout of each element were optimized to increase the local gradient strength while minimizing eddy current effects and simultaneously considering manufacturing constraints...
April 25, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28444679/membranes-derived-from-human-umbilical-cord-wharton-s-jelly-stem-cells-as-novel-bioengineered-tissue-like-constructs
#10
B D Jaimes-Parra, I Garzón, V Carriel, D Durand-Herrera, M A Martín-Piedra, J M García, M C Sánchez-Quevedo, M Alaminos, A Campos
Cell-derived matrices were recently described as novel biomaterials generated by human cells allowed to grow and synthetize their own extracellular matrix in culture. In the present work, we generated and evaluated a novel tissue-like substitute (WDM) consisting of a membrane derived from cultured human Wharton's jelly stem cells. WDM were evaluated ex vivo and in vivo by histochemistry and immunohistochemistry for several mesenchymal cell markers and fibrillar and non-fibrillar extracellular matrix components...
April 26, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28444384/e-science-technologies-in-a-workflow-for-personalized-medicine-using-cancer-screening-as-a-case-study
#11
Ola Spjuth, Andreas Karlsson, Mark Clements, Keith Humphreys, Emma Ivansson, Jim Dowling, Martin Eklund, Alexandra Jauhiainen, Kamila Czene, Henrik Grönberg, Pär Sparén, Fredrik Wiklund, Abbas Cheddad, Þorgerður Pálsdóttir, Mattias Rantalainen, Linda Abrahamsson, Erwin Laure, Jan-Eric Litton, Juni Palmgren
Objective: We provide an e-Science perspective on the workflow from risk factor discovery and classification of disease to evaluation of personalized intervention programs. As case studies, we use personalized prostate and breast cancer screenings. Materials and Methods: We describe an e-Science initiative in Sweden, e-Science for Cancer Prevention and Control (eCPC), which supports biomarker discovery and offers decision support for personalized intervention strategies...
April 21, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28443949/is-reiki-or-prayer-effective-in-relieving-pain-during-hospitalization-for-cesarean-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Guilherme Augusto Rago Ferraz, Meline Rosseto Kron Rodrigues, Silvana Andrea Molina Lima, Marcelo Aparecido Ferraz Lima, Gabriela Lopes Maia, Carlos Alberto Pilan, Michelle Sako Omodei, Ana Cláudia Molina, Regina El Dib, Marilza Vieira Cunha Rudge
CONTEXT AND OBJECTIVE: This systematic review compared reiki and prayer with drug use for relieving pain during hospitalization for cesarean, given that the popularity of integrative medicine and spiritual healing has been increasing. It had the aim of evaluating whether reiki or prayer is effective in relieving pain during cesarean section. DESIGN AND SETTING: Systematic review with meta-analysis conducted at Botucatu Medical School, UNESP, São Paulo, Brazil. METHODS: The following databases were searched up to March 2016: MEDLINE, Embase, LILACS and CENTRAL...
April 20, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28443130/modular-design-of-picroside-ii-biosynthesis-deciphered-through-ngs-transcriptomes-and-metabolic-intermediates-analysis-in-naturally-variant-chemotypes-of-a-medicinal-herb-picrorhiza-kurroa
#13
Varun Kumar, Ankush Bansal, Rajinder S Chauhan
Picroside-II (P-II), an iridoid glycoside, is used as an active ingredient of various commercial herbal formulations available for the treatment of liver ailments. Despite this, the knowledge of P-II biosynthesis remains scarce owing to its negligence in Picrorhiza kurroa shoots which sets constant barrier for function validation experiments. In this study, we utilized natural variation for P-II content in stolon tissues of different P. kurroa accessions and deciphered its metabolic route by integrating metabolomics of intermediates with differential NGS transcriptomes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28442961/integration-of-simulation-in-postgraduate-studies-in-saudi-arabia-the-current-practice-in-anesthesia-training-program
#14
REVIEW
Abeer Arab, Abdulaleem Alatassi, Elias Alattas, Usamah Alzoraigi, Zaki AlZaher, Abdulaziz Ahmad, Hesham Albabtain, Abdulaziz Boker
The educational programs in the Saudi Commission for Health Specialties are developing rapidly in the fields of technical development. Such development is witnessed, particularly in the scientific areas related to what is commonly known as evidence-based medicine. This review highlights the critical need and importance of integrating simulation into anesthesia training and assessment. Furthermore, it describes the current utilization of simulation in anesthesia and critical care assessment process.
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28442515/genetic-polymorphisms-rs699947-rs1570360-and-rs3025039-on-the-vegf-gene-are-correlated-with-extracranial-internal-carotid-artery-stenosis-and-ischemic-stroke
#15
Binod Kumar Yadav, Renu Yadav, Hyuk Chang, Kangho Choi, Joon-Tae Kim, Man Seok Park, Hyun Goo Kang, Insung Choo, Seong Hwan Ahn, Dong Seok Oh, Yeon Soo Ha, Ihngyu Kim, Man-Wook Seo, Byoung-Soo Shin
Extracranial internal carotid artery (ECICA) stenosis is a modifiable risk factor of ischemic stroke. VEGF plays a crucial role in the maintenance of endothelial integrity and physiological function. This study was designed to assess the correlations of VEGF polymorphisms with ECICA stenosis in ischemic stroke and to explore the relationships between these polymorphisms and different biochemical parameters. This study included a total of 650 ischemic stroke patients, 232 with ECICA stenosis while 418 had no ECICA stenosis as assessed by magnetic resonance angiography...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28442298/how-to-study-and-overcome-tumor-heterogeneity-with-circulating-biomarkers-the-breast-cancer-case
#16
REVIEW
Valentina Appierto, Serena Di Cosimo, Carolina Reduzzi, Valentina Pala, Vera Cappelletti, Maria Grazia Daidone
Breast cancer ranks first among female cancer-related deaths in Western countries. As the primary tumor can often be controlled by surgical resection, the survival of women with breast cancer is closely linked to the incidence of distant metastases. Molecular screening by next generation sequencing highlighted the spatial and temporal heterogeneity of solid tumors as well as the clonal evolution of cancer cells during progression and under treatment pressure. Such findings question whether an optimal assessment of disease progression and a screening for druggable mutations should be based on molecular features of primary or recurrent/metastatic lesions and therefore represent a crucial element for failure or success of personalized medicine...
April 22, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28441505/error-detection-based-model-to-assess-educational-outcomes-in-crisis-resource-management-training-a-pilot-study
#17
Sarah Bouhabel, Emily Kay-Rivest, Carol Nhan, Ilana Bank, Peter Nugus, Rachel Fisher, Lily Hp Nguyen
Otolaryngology-head and neck surgery (OTL-HNS) residents face a variety of difficult, high-stress situations, which may occur early in their training. Since these events occur infrequently, simulation-based learning has become an important part of residents' training and is already well established in fields such as anesthesia and emergency medicine. In the domain of OTL-HNS, it is gradually gaining in popularity. Crisis Resource Management (CRM), a program adapted from the aviation industry, aims to improve outcomes of crisis situations by attempting to mitigate human errors...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28441481/best-practices-of-computer-aided-drug-discovery-cadd-lessons-learned-from-the-development-of-a-preclinical-candidate-for-prostate-cancer-with-a-new-mechanism-of-action
#18
Fuqiang Ban, Kush Dalal, Huifang Li, Eric LeBlanc, Paul S Rennie, Artem Cherkasov
Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Low molecular weight chemicals represent an attractive therapeutic option as they are readily accessible to organic synthesis and can easily be characterized.1 Their potency, as well as pharmacokinetic and pharmacodynamic properties can be systematically and rationally investigated, and ultimately optimized via expert science behind medicinal chemistry and methods of computer-aided drug design (CADD)...
April 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28441057/oxidative-stress
#19
Helmut Sies, Carsten Berndt, Dean P Jones
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative eustress, is essential for governing life processes through redox signaling. Recent interest has focused on the intricate ways by which redox signaling integrates these converse properties. Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-κB/IκB is used for system-wide oxidative stress response...
April 24, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28440999/-epistemic-injustice-during-the-medical-education-process-in-the-hospital-context
#20
Carolina Consejo-Y Chapela, Carlos Alfonso Viesca-Treviño
BACKGROUND: The educational model adopted by the Universidad Nacional Autónoma de México (UNAM) Faculty of Medicine is constructivist; it is a model based on competence development. It aims to provide learning environments that incorporate real activities (it helps the students to develop social negotiation skills, as part of their integral learning; it encourages them to take a critical and reflexive approach; and it is also a student-centered model). However, many challenges arise when this model is implemented in the context of hospital environments...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
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