keyword
MENU ▼
Read by QxMD icon Read
search

eGFR rate of decline

keyword
https://www.readbyqxmd.com/read/29453652/significance-of-the-nonneoplastic-renal-parenchymal-findings-in-robotic-partial-nephrectomy-series
#1
Ercan Malkoç, Matthew J Maurice, Oktay Akça, Önder Kara, Homayoun Zargar, Hiury Andrade, Daniel Ramirez, Peter Caputo, Robert Stein, Demirjian Sevag, Jihad H Kaouk
AIM: To describe the pathological characteristics of the peritumoral non-neoplastic renal parenchyma (NNRP) and to investigate their impact on long-term renal function after partial nephrectomy. MATERIALS AND METHODS: In our institutional robotic partial nephrectomy database, we identified 394 cases with pathological assessment of the NNRP and long-term postoperative renal functional follow-up. The NNRP was classified as normal (healthy renal parenchyma) or abnormal, based on the presence of arteriosclerosis, glomerulosclerosis, interstitial fibrosis, interstitial inflammation, and/or tubulopapillary hyperplasia...
February 16, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29452887/protein-intake-and-long-term-change-in-glomerular-filtration-rate-in-the-jackson-heart-study
#2
Rakesh Malhotra, Loren Lipworth, Kerri L Cavanaugh, Bessie A Young, Katherine L Tucker, Teresa C Carithers, Herman A Taylor, Adolfo Correa, Edmond K Kabagambe, T Alp Ikizler
OBJECTIVE: Dietary protein intake could have deleterious renal effects in populations at risk for chronic kidney disease. Here, we examined whether higher protein intake (≥80th percentile of energy from protein) is associated with decline in kidney function and whether this decline varies by diabetes status. DESIGN: Observational cohort study. SUBJECTS AND SETTINGS: Participants were African-Americans (n = 5,301), who enrolled in the Jackson Heart Study between 2000 and 2004...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29446007/significance-of-early-detection-of-acute-kidney-function-worsening-among-outpatients-having-ckd-using-automatic-calculation-system-for-the-rate-of-egfr-decline
#3
Jun Ito, Hirofumi Kita, Takashi Fujisawa
BACKGROUND: To retard progression of chronic kidney disease (CKD) and reduce end-stage kidney disease, it is important to detect acute kidney function worsening on CKD (AW-CKD) immediately and bring back their kidney functions to baselines by appropriate treatment. However, in general outpatient practice, it is difficult to detect the change in the slope of estimated glomerular filtration rate (eGFR). METHODS: We made automatic calculation system for the rate of eGFR decline (ΔeGFR), and retrospectively observed the situation of AW-CKD among outpatients, who had visited all clinical departments of Steel Memorial Hirohata Hospital between May and August 2016, using the system...
February 14, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29444269/association-of-angiotensin-ii-type-1-receptor-antibodies-with-graft-histology-function-and-survival-in-paediatric-renal-transplant-recipients
#4
Alexander Fichtner, Caner Süsal, Claudia Schröder, Britta Höcker, Susanne Rieger, Rüdiger Waldherr, Jens H Westhoff, Anja Sander, Duska Dragun, Burkhard Tönshoff
Background: We analysed in a carefully phenotyped cohort of paediatric patients the association of serum angiotensin II type 1 receptor antibodies (AT1R-Ab) with specific histological lesions and with graft function and survival in conjunction with overall and complement-binding donor-specific human leucocyte antigen donor-specific antibodies (HLA-DSA). Methods: Sera of 62 patients at the time of renal graft biopsy for clinical indication >1 year post-transplant were assessed for AT1R-Ab by enzyme-linked immunosorbent assay (ELISA) and for DSA and C1q-fixing DSA by single-antigen bead technology...
February 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29439930/low-protein-intake-in-the-population-low-risk-of-kidney-function-decline-but-high-risk-of-mortality
#5
Massimo Cirillo, Pierpaolo Cavallo, Giancarlo Bilancio, Cinzia Lombardi, Oscar Terradura Vagnarelli, Martino Laurenzi
OBJECTIVE: This population-based study investigated low protein intake, mortality, and kidney function decline. DESIGN: Observational longitudinal cohort study. SUBJECTS: Target cohort consisted of 4,679 adults participating in 1988-1992 and 2001-2007 examinations of the Gubbio Study (baseline and follow-up). Data collection included overnight urine urea nitrogen (UUN) and other variables at baseline, serum creatinine at baseline and follow-up, and mortality from baseline to follow-up...
February 10, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29426298/albuminuria-serum-creatinine-and-estimated-glomerular-filtration-rate-as-predictors-of-cardio-renal-outcomes-in-patients-with-type-2-diabetes-mellitus-and-kidney-disease-a-systematic-literature-review
#6
Keith C Norris, Karen E Smoyer, Catherine Rolland, Jan Van der Vaart, Eliza Beth Grubb
BACKGROUND: Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid represent independent predictors of kidney disease progression or subsequent outcomes among individuals with type 2 diabetes mellitus (T2DM). This study systematically examined the available literature documenting the role of albuminuria, serum creatinine, eGFR, and uric acid in predicting kidney disease progression and cardio-renal outcomes in persons with T2DM...
February 9, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29409725/treatment-of-rheumatoid-arthritis-with-biologic-agents-lowers-the-risk-of-incident-chronic-kidney-disease
#7
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fatima Hassan, Fridtjof Thomas, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
Rheumatoid arthritis is associated with reduced kidney function, possibly due to chronic inflammation or the use of nephrotoxic therapies. However, little is known about the effects of using the newer novel non-nephrotoxic biologic agents on the risk of incident chronic kidney disease (CKD). To study this we used a cohort of 20,757 United States veterans diagnosed with rheumatoid arthritis with an estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73m2 or more, recruited between October 2004 and September 2006, and followed through 2013...
February 3, 2018: Kidney International
https://www.readbyqxmd.com/read/29404927/fast-gfr-decline-and-progression-to-ckd-among-primary-care-patients-with-preserved-gfr
#8
Farrukh M Koraishy, Denise Hooks-Anderson, Joanne Salas, Michael Rauchman, Jeffrey F Scherrer
BACKGROUND: Fast glomerular filtration rate (GFR) decline is associated with adverse outcomes, but the associated risk factors among patients without chronic kidney disease (CKD) are not well defined. METHODS: From a primary care registry of 37,796, we identified 2219 (6%) adults with at least three estimated (e)GFR values and a baseline eGFR between 60 and 119 ml/min/1.73 m2 during an observation period of 8 years. We defined fast GFR decline as > 5 ml/min/1...
February 5, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29402767/bardoxolone-methyl-improves-kidney-function-in-patients-with-chronic-kidney-disease-stage-4-and-type-2-diabetes-post-hoc-analyses-from-bardoxolone-methyl-evaluation-in-patients-with-chronic-kidney-disease-and-type-2-diabetes-study
#9
Melanie P Chin, George L Bakris, Geoffrey A Block, Glenn M Chertow, Angie Goldsberry, Lesley A Inker, Hiddo J L Heerspink, Megan O'Grady, Pablo E Pergola, Christoph Wanner, David G Warnock, Colin J Meyer
BACKGROUND: Increases in measured inulin clearance, measured creatinine clearance, and estimated glomerular filtration rate (eGFR) have been observed with bardoxolone methyl in 7 studies enrolling approximately 2,600 patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The largest of these studies was Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON), a multinational, randomized, double-blind, placebo-controlled phase 3 trial which enrolled patients with T2D and CKD stage 4...
January 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29395351/end-stage-renal-disease-and-mortality-outcomes-across-different-glomerulonephropathies-in-a-large-diverse-us-population
#10
John J Sim, Simran K Bhandari, Michael Batech, Aviv Hever, Teresa N Harrison, Yu-Hsiang Shu, Dean A Kujubu, Tracy Y Jonelis, Michael H Kanter, Steven J Jacobsen
OBJECTIVE: To compare renal function decline, incident end-stage renal disease (ESRD), and mortality among patients with 5 common glomerular diseases in a large diverse population. PATIENTS AND METHODS: A retrospective cohort study (between January 1, 2000, and December 31, 2011) of patients with glomerulonephropathy using the electronic health record of an integrated health system was performed. Estimated glomerular filtration rate (eGFR) change, incident ESRD, and mortality were compared among patients with biopsy-proven focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MN), minimal change disease (MCD), immunoglobulin A nephropathy (IgAN), and lupus nephritis (LN)...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29393842/a-study-of-urinary-tamm-horsfall-protein-excretion-in-adult-type-2-diabetes-mellitus%C3%A2
#11
Mao Zheng, Shandong Ye, Yan Chen, Meinan Chen
AIM: To study the excretion of urinary Tamm-Horsfall protein (THP) with a wide range of urinary albumin creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) in a population with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: A retrospective investigation was performed in 3,599 adult inpatients with T2DM in Anhui Provincial Hospital of China. Demographic information, urinary THP data, and other lab reports were obtained from the Electronic Patient Record (EPR)...
February 2, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29391834/independent-and-combined-effect-of-bilirubin-and-smoking-on-the-progression-of-chronic-kidney-disease
#12
Jiancheng Wang, Binyan Wang, Min Liang, Guobao Wang, Jianping Li, Yan Zhang, Yong Huo, Yimin Cui, Xiping Xu, Xianhui Qin
Objective: Whether serum bilirubin and cigarette smoking affect the risk of renal function decline remains inconclusive. We aimed to test the independent and combined effects of bilirubin and cigarette smoking on the progression of chronic kidney disease (CKD) in hypertensive adults. Methods: The study population consisted of 12,633 patients in the renal sub-study of the China Stroke Primary Prevention Trial. The primary outcome was progression of CKD, defined as a decrease in estimated glomerular filtration rate (eGFR) of ≥30% and to a level of <60 mL/min/1...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29390103/non-alcoholic-fatty-liver-disease-and-clinical-outcomes-in-chronic-kidney-disease
#13
Rajkumar Chinnadurai, James Ritchie, Darren Green, Philip A Kalra
Background: Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor associated with cardiovascular disease (CVD) and incidence of chronic kidney disease (CKD). NAFLD is threatening to become a major public health problem in association with the metabolic syndrome. The association of NAFLD with outcomes in patients with advanced CKD has not been evaluated. In this study, the prevalence of NAFLD and its impact on cardiovascular and renal outcomes and mortality were determined in a large secondary care CKD cohort...
January 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29377515/impact-of-interferon-free-regimens-on-the-glomerular-filtration-rate-during-treatment-of-chronic-hepatitis-c-in-a-real-life-cohort
#14
María Jesús Alvarez-Ossorio, Rui Sarmento E Castro, Rafael Granados, Juan Macías, Luis E Morano-Amado, María J Ríos, Dolores Merino, Enrique Nuño Álvarez, Antonio Collado, Montserrat Pérez-Pérez, Francisco Téllez, José María Martín, Josefina Méndez, Juan A Pineda, Karin Neukam
Little data is available on renal toxicity exerted by direct-acting antivirals (DAAs) in real-life. The aim of this study was to assess the impact of direct-acting antivirals against hepatitis C virus infection currently used in Spain and Portugal on the estimated glomerular filtration rate (eGFR) in clinical practise. From an international, prospective multicohort study, patients treated with DAAs for at least 12 weeks and with eGFR ≥30 ml/min/1.73 m2 at baseline were selected. eGFR was determined using the CKD-EPI formula...
January 28, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29372470/uric-acid-lowering-and-renoprotective-effects-of-topiroxostat-a-selective-xanthine-oxidoreductase-inhibitor-in-patients-with-diabetic-nephropathy-and-hyperuricemia-a-randomized-double-blind-placebo-controlled-parallel-group-study-upward-study
#15
Takashi Wada, Tatsuo Hosoya, Daisuke Honda, Ryusuke Sakamoto, Kazutaka Narita, Tomomitsu Sasaki, Daisuke Okui, Kenjiro Kimura
BACKGROUND: Hyperuricemia is supposed to be an independent risk factor for kidney dysfunction in diabetic patients. We attempted to examine the uric acid-lowering effect and the renoprotective effect of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia in this pilot study. METHODS: The study design was randomized, double-blind, placebo-controlled, parallel-group study. A total of 65 patients with hyperuricemia and diabetic nephropathy with microalbuminuria were enrolled and assigned to either the topiroxostat group or the placebo group...
January 25, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29369156/hepatitis-c-virus-cure-does-not-impact-kidney-function-decline-in-hiv-co-infected-patients
#16
Carmine Rossi, Sahar Saeed, Joseph Cox, Marie-Louise Vachon, Valérie Martel-Laferrière, Sharon L Walmsley, Curtis Cooper, M John Gill, Mark Hull, Erica E M Moodie, Marina B Klein
OBJECTIVE: To examine the impact of sustained virologic response (SVR) and illicit (injection and non-injection) drug use on kidney function among hepatitis C virus (HCV) and HIV co-infected individuals. DESIGN: Longitudinal observational cohort study of HCV-HIV co-infected patients. METHODS: Data from 1,631 patients enrolled in the Canadian Co-Infection Cohort between 2003 and 2016 were analyzed. Patients who achieved SVR were matched 1:2 with chronically infected patients using time-dependent propensity scores...
January 23, 2018: AIDS
https://www.readbyqxmd.com/read/29367427/high-baseline-levels-of-tumor-necrosis-factor-receptor-1-are-associated-with-progression-of-kidney-disease-in-indigenous-australians-with-diabetes-the-egfr-follow-up-study
#17
Elizabeth L M Barr, Federica Barzi, Jaquelyne T Hughes, George Jerums, Wendy E Hoy, Kerin O'Dea, Graham Jones, Paul D Lawton, Alex D H Brown, Mark Thomas, Elif I Ekinci, Ashim Sinha, Alan Cass, Richard J MacIsaac, Louise J Maple-Brown
OBJECTIVE: To examine the association between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and kidney disease progression in Indigenous Australians at high risk of kidney disease. RESEARCH DESIGN AND METHODS: This longitudinal observational study examined participants aged ≥18 years recruited from >20 sites across diabetes and/or kidney function strata. Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history...
January 24, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29366878/trajectories-of-egfr-decline-over-a-four-year-period-in-an-indigenous-australian-population-at-high-risk-of-ckd-the-egfr-follow-up-study
#18
Federica Barzi, Graham R D Jones, Jaquelyne T Hughes, Paul D Lawton, Wendy Hoy, Kerin O'Dea, George Jerums, Richard J MacIsaac, Alan Cass, Louise J Maple-Brown
Being able to estimate kidney decline accurately is particularly important in Indigenous Australians, a population at increased risk of developing chronic kidney disease and end stage kidney disease. The aim of this analysis was to explore the trend of decline in estimated glomerular filtration rate (eGFR) over a four year period using multiple local creatinine measures, compared with estimates derived using centrally-measured enzymatic creatinine and with estimates derived using only two local measures. METHOD: The eGFR study comprised a cohort of over 600 Aboriginal Australian participants recruited from over twenty sites in urban, regional and remote Australia across five strata of health, diabetes and kidney function...
January 20, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29365049/reproductive-failure-in-mice-expressing-transgenic-follicle-stimulating-hormone-is-not-caused-by-loss-of-oocyte-quality
#19
Dannielle H Upton, Kirsty A Walters, Kirsten J McTavish, Janet Holt, David J Handelsman, Charles M Allan
Human female reproductive aging features declining ovarian follicle reserve and oocyte quality, and rising levels of circulating follicle stimulating hormone (FSH). We determined the effects of elevated FSH on oocyte-embryo development in mature mice exhibiting premature infertility caused by progressively rising transgenic human FSH (TgFSH) levels. Oocyte-embryo developmental competence and quality were examined using oocyte maturation and aneuploidy rates, biomarkers of oocyte quality, and reciprocal embryo transfers assessed for implantation and pregnancy...
January 22, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29360915/the-effects-of-egfr-change-on-cvd-renal-and-mortality-outcomes-in-a-hypertensive-cohort-treated-with-3-different-antihypertensive-medications
#20
Joshua I Barzilay, Barry R Davis, Sara L Pressel, Alokananda Ghosh, Mahboob Rahman, Paula T Einhorn, William C Cushman, Paul K Whelton, Jackson T Wright
BACKGROUND: Impaired renal function is a risk factor for cardiovascular disease, end-stage renal disease (ESRD), and mortality. The impact of short-term renal function decline on outcomes is less well studied. The association of antihypertensive medications with the impact of short-term estimated glomerular filtration rate (eGFR) decline is not known. METHODS: We examined 20,207 hypertensive participants with baseline and 2-year creatinine levels from which eGFR changes were estimated...
January 19, 2018: American Journal of Hypertension
keyword
keyword
44847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"