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Frank B. Hu

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https://www.readbyqxmd.com/read/28888344/plasma-retinol-binding-protein-4-levels-and-the-risk-of-ischemic-stroke-among-women
#1
Pamela M Rist, Monik C Jiménez, Shelley S Tworoger, Frank B Hu, JoAnn E Manson, Qi Sun, Kathryn M Rexrode
BACKGROUND: Plasma retinol-binding protein 4 (RBP4) levels have been associated with cardiovascular risk factors and risk of coronary heart disease, but little is known about the association between RBP4 and the risk of ischemic stroke. We hypothesized that elevated RBP4 levels would be associated with an increased risk of ischemic stroke among women. METHODS: We performed a nested case-control study among women enrolled in the Nurses' Health Study who provided blood samples between 1989 and 1990 and were free of prior stroke and cancer...
September 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28887409/longitudinal-change-in-fasting-blood-glucose-and-myocardial-infarction-risk-in-a-population-without-diabetes
#2
Cheng Jin, Shuohua Chen, Anand Vaidya, Yuntao Wu, Zhijun Wu, Frank B Hu, Penny Kris-Etherton, Shouling Wu, Xiang Gao
OBJECTIVE: To examine the change in fasting blood glucose (FBG) during repeated assessments over time and its potential impact on the risk of developing myocardial infarction (MI). RESEARCH DESIGN AND METHODS: This prospective cohort study included 68,297 participants without diabetes (mean age 49 years) who were free of MI, stroke, and cancer prior to or in 2010 (baseline of the current analysis). FBG concentrations were measured in 2006, 2008, and 2010. The FBG trajectories during 2006-2010, the primary exposure of the current study, were identified by latent mixture modeling...
September 8, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28882871/independent-and-synergistic-associations-of-biomarkers-of-vitamin-d-status-with-risk-of-coronary-heart-disease
#3
Lu Qi, Wenjie Ma, Yoriko Heianza, Yan Zheng, Tiange Wang, Dianjianyi Sun, Eric B Rimm, Frank B Hu, Edward Giovannucci, Christine M Albert, Kathryn M Rexrode, JoAnn E Manson
OBJECTIVE: To comprehensively evaluate the independent associations and potential interactions of vitamin D-related biomarkers including total and bioavailable 25-hydroxyvitamin D (25OHD), VDBP (vitamin D binding protein), and parathyroid hormone (PTH) with risk of coronary heart disease (CHD). APPROACH AND RESULTS: We prospectively identified incident cases of nonfatal myocardial infarction and fatal CHD among women in the Nurses' Health Study during 20 years of follow-up (1990-2010)...
September 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28854932/a-healthy-approach-to-dietary-fats-understanding-the-science-and-taking-action-to-reduce-consumer-confusion
#4
REVIEW
Ann G Liu, Nikki A Ford, Frank B Hu, Kathleen M Zelman, Dariush Mozaffarian, Penny M Kris-Etherton
Consumers are often confused about nutrition research findings and recommendations. As content experts, it is essential that nutrition scientists communicate effectively. A case-study of the history of dietary fat science and recommendations is presented, summarizing presentations from an Experimental Biology Symposium that addressed techniques for effective scientific communication and used the scientific discourse of public understanding of dietary fats and health as an example of challenges in scientific communication...
August 30, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28814398/plasma-lipidomic-profiles-and-cardiovascular-events-in-a-randomized-intervention-trial-with-the-mediterranean-diet
#5
Estefanía Toledo, Dong D Wang, Miguel Ruiz-Canela López, Clary B Clish, Cristina Razquin, Yan Zheng, Marta Guasch-Ferré, Adela Hruby, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, Emilio Ros, José Lapetra, Montserrat Fito, Fernando Aros, Luis Serra-Majem, Liming Liang, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).Objective: We evaluated the associations between 1) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subsequent CVD.Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)]...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28811361/chemoradiotherapy-resistance-in-colorectal-cancer-cells-is-mediated-by-wnt-%C3%AE-catenin-signaling
#6
Georg Emons, Melanie Spitzner, Sebastian Reineke, Janneke Möller, Noam Auslander, Frank Kramer, Yue Hu, Tim Beissbarth, Hendrik A Wolff, Margret Rave-Fränk, Elisabeth Heßmann, Jochen Gaedcke, B Michael Ghadimi, Steven A Johnsen, Thomas Ried, Marian Grade
Activation of Wnt/β-catenin signaling plays a central role in the development and progression of colorectal cancer. The Wnt-transcription factor, TCF7L2, is overexpressed in primary rectal cancers that are resistant to chemoradiotherapy and TCF7L2 mediates resistance to chemoradiotherapy. However, it is unclear whether the resistance is mediated by a TCF7L2 inherent mechanism or Wnt/β-catenin signaling in general. Here, inhibition of β-catenin by siRNAs or a small-molecule inhibitor (XAV-939) resulted in sensitization of colorectal cancer cells to chemoradiotherapy...
August 15, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28747298/estimating-one-year-risk-of-incident-chronic-kidney-disease-retrospective-development-and-validation-study-using-electronic-medical-record-data-from-the-state-of-maine
#7
Shiying Hao, Tianyun Fu, Qian Wu, Bo Jin, Chunqing Zhu, Zhongkai Hu, Yanting Guo, Yan Zhang, Yunxian Yu, Terry Fouts, Phillip Ng, Devore S Culver, Shaun T Alfreds, Frank Stearns, Karl G Sylvester, Eric Widen, Doff B McElhinney, Xuefeng B Ling
BACKGROUND: Chronic kidney disease (CKD) is a major public health concern in the United States with high prevalence, growing incidence, and serious adverse outcomes. OBJECTIVE: We aimed to develop and validate a model to identify patients at risk of receiving a new diagnosis of CKD (incident CKD) during the next 1 year in a general population. METHODS: The study population consisted of patients who had visited any care facility in the Maine Health Information Exchange network any time between January 1, 2013, and December 31, 2015, and had no history of CKD diagnosis...
July 26, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28745975/identification-of-chemical-compounds-that-inhibit-the-function-of-histidyl-trna-synthetase-from-pseudomonas-aeruginosa
#8
Yanmei Hu, Stephanie O Palmer, Sara T Robles, Tahyra Resto, Frank B Dean, James M Bullard
Pseudomonas aeruginosa histidyl-tRNA synthetase (HisRS) was selected as a target for antibiotic drug development. The HisRS protein was overexpressed in Escherichia coli and kinetically evaluated. The KM values for interaction of HisRS with its three substrates, histidine, ATP, and tRNA(His), were 37.6, 298.5, and 1.5 μM, while the turnover numbers were 8.32, 16.8, and 0.57 s(-1), respectively. A robust screening assay was developed, and 800 natural products and 890 synthetic compounds were screened for inhibition of activity...
July 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28738312/habitual-sleep-quality-and-diurnal-rhythms-of-salivary-cortisol-and-dehydroepiandrosterone-in-postmenopausal-women
#9
Tianyi Huang, Elizabeth M Poole, Celine Vetter, Kathryn M Rexrode, Laura D Kubzansky, Eva Schernhammer, Nicolas Rohleder, Frank B Hu, Susan Redline, Shelley S Tworoger
Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has been suggested as a potential mechanism linking sleep and cardiometabolic disorders. However, the associations of two primary outputs of the HPA axis, cortisol and its antagonist dehydroepiandrosterone (DHEA), with sleep are less well studied. In the Nurses' Health Study II, 233 postmenopausal women provided five timed saliva samples over one day (immediately upon waking, 45min, 4h, and 10h after waking, and prior to going to sleep) to measure cortisol and DHEA...
October 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28728684/healthful-and-unhealthful-plant-based-diets-and-the-risk-of-coronary-heart%C3%A2-disease-in-u-s-adults
#10
Ambika Satija, Shilpa N Bhupathiraju, Donna Spiegelman, Stephanie E Chiuve, JoAnn E Manson, Walter Willett, Kathryn M Rexrode, Eric B Rimm, Frank B Hu
BACKGROUND: Plant-based diets are recommended for coronary heart disease (CHD) prevention. However, not all plant foods are necessarily beneficial for health. OBJECTIVES: This study sought to examine associations between plant-based diet indices and CHD incidence. METHODS: We included 73,710 women in NHS (Nurses' Health Study) (1984 to 2012), 92,329 women in NHS2 (1991 to 2013), and 43,259 men in Health Professionals Follow-up Study (1986 to 2012), free of chronic diseases at baseline...
July 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28724646/association-between-microbiota-dependent-metabolite-trimethylamine-n-oxide-and-type-2-diabetes
#11
Zhilei Shan, Taoping Sun, Hao Huang, Sijing Chen, Liangkai Chen, Cheng Luo, Wei Yang, Xuefeng Yang, Ping Yao, Jinquan Cheng, Frank B Hu, Liegang Liu
Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.Objective: We evaluated the association of plasma TMAO with newly diagnosed type 2 diabetes and the potential modification of TMAO-generating enzyme flavin monooxygenase 3 (FMO3) polymorphisms.Design: This was an age- and sex-matched case-control study of 2694 participants: 1346 newly diagnosed cases of type 2 diabetes and 1348 controls. Concentrations of plasma TMAO were measured, and FMO3 E158K polymorphisms (rs2266782) were genotyped...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28719691/associations-of-weight-gain-from-early-to-middle-adulthood-with-major-health-outcomes-later-in-life
#12
Yan Zheng, JoAnn E Manson, Changzheng Yuan, Matthew H Liang, Francine Grodstein, Meir J Stampfer, Walter C Willett, Frank B Hu
Importance: Data describing the effects of weight gain across adulthood on overall health are important for weight control. Objective: To examine the association of weight gain from early to middle adulthood with health outcomes later in life. Design, Setting, and Participants: Cohort analysis of US women from the Nurses' Health Study (1976-June 30, 2012) and US men from the Health Professionals Follow-Up Study (1986-January 31, 2012) who recalled weight during early adulthood (at age of 18 years in women; 21 years in men), and reported current weight during middle adulthood (at age of 55 years)...
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28701334/genetic-susceptibility-change-in-physical-activity-and-long-term-weight-gain
#13
Tiange Wang, Tao Huang, Yoriko Heianza, Dianjianyi Sun, Yan Zheng, Wenjie Ma, Majken K Jensen, Jae H Kang, Janey L Wiggs, Louis R Pasquale, Eric B Rimm, JoAnn E Manson, Frank B Hu, Walter C Willett, Lu Qi
Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a body mass index (BMI)-genetic risk score (GRS) based on 77 BMI-associated single-nucleotide polymorphisms (SNPs) and a body fat percentage (BF%)-GRS based on 12 BF%-associated SNPs, respectively, in 9,390 women from the Nurses' Health Study (NHS) and 5,291 men from the Health Professionals Follow-up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses...
July 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28700845/association-of-changes-in-diet-quality-with-total-and-cause-specific-mortality
#14
Mercedes Sotos-Prieto, Shilpa N Bhupathiraju, Josiemer Mattei, Teresa T Fung, Yanping Li, An Pan, Walter C Willett, Eric B Rimm, Frank B Hu
BACKGROUND: Few studies have evaluated the relationship between changes in diet quality over time and the risk of death. METHODS: We used Cox proportional-hazards models to calculate adjusted hazard ratios for total and cause-specific mortality among 47,994 women in the Nurses' Health Study and 25,745 men in the Health Professionals Follow-up Study from 1998 through 2010. Changes in diet quality over the preceding 12 years (1986-1998) were assessed with the use of the Alternate Healthy Eating Index-2010 score, the Alternate Mediterranean Diet score, and the Dietary Approaches to Stop Hypertension (DASH) diet score...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28700699/smoking-during-pregnancy-in-relation-to-grandchild-birth-weight-and-bmi-trajectories
#15
Ming Ding, Changzheng Yuan, Audrey J Gaskins, Alison E Field, Stacey A Missmer, Karin B Michels, Frank Hu, Cuilin Zhang, Matthew W Gillman, Jorge Chavarro
BACKGROUND: Maternal smoking has been linked to lower birth weight and higher risk of childhood obesity. However, it is unknown whether grand-maternal smoking during pregnancy is associated with grandchildren birth weight and body mass index (BMI) trajectories. METHODS: We investigated associations of smoking during pregnancy with birth weight, risks of overweight and BMI trajectories among 46,858 mother-child dyads and 6,583 grandmother-mother-child triads of three cohort studies of related individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28694524/prevalence-of-overweight-and-obesity-in-15-8-million-men-aged-15-49-years-in-rural-china-from-2010-to-2014
#16
Yuan He, An Pan, Yuanyuan Wang, Ying Yang, Jihong Xu, Ya Zhang, Dujia Liu, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Zuoqi Peng, Frank B Hu, Xu Ma
Obesity has been increasing worldwide. Data on obesity status among men of reproductive age are scarce. This study aimed to assess the national prevalence and trend of overweight and obesity among reproductive-age men in rural China. In the nationwide population-based study, data were obtained from the National Free Preconception Health Examination Project in rural China from 2010 to 2014. Weight and height were measured in 16 161 982 men aged 15-49 years and their female partners (15 997 739 participants aged 15-49 years) before conception, and body mass index (BMI) was calculated...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28686739/defining-and-characterizing-the-critical-transition-state-prior-to-the-type-2-diabetes-disease
#17
Bo Jin, Rui Liu, Shiying Hao, Zhen Li, Chunqing Zhu, Xin Zhou, Pei Chen, Tianyun Fu, Zhongkai Hu, Qian Wu, Wei Liu, Daowei Liu, Yunxian Yu, Yan Zhang, Doff B McElhinney, Yu-Ming Li, Devore S Culver, Shaun T Alfreds, Frank Stearns, Karl G Sylvester, Eric Widen, Xuefeng B Ling
BACKGROUND: Type 2 diabetes mellitus (T2DM), with increased risk of serious long-term complications, currently represents 8.3% of the adult population. We hypothesized that a critical transition state prior to the new onset T2DM can be revealed through the longitudinal electronic medical record (EMR) analysis. METHOD: We applied the transition-based network entropy methodology which previously identified a dynamic driver network (DDN) underlying the critical T2DM transition at the tissue molecular biological level...
2017: PloS One
https://www.readbyqxmd.com/read/28674038/genetic-interference-with-endothelial-ppar-%C3%AE-peroxisome-proliferator-activated-receptor-%C3%AE-augments-effects-of-angiotensin-ii-while-impairing-responses-to-angiotensin-1-7
#18
T Michael De Silva, Chunyan Hu, Dale A Kinzenbaw, Mary L Modrick, Curt D Sigmund, Frank M Faraci
Pharmacological activation of PPAR-γ (peroxisome proliferator-activated receptor-γ) protects the vasculature. Much less is known on the cell-specific impact of PPAR-γ when driven by endogenous ligands. Recently, we found that endothelial PPAR-γ protects against angiotensin II-induced endothelial dysfunction. Here, we explored that concept further examining whether effects were sex dependent along with underlying mechanisms. We studied mice expressing a human dominant-negative mutation in PPAR-γ driven by the endothelial-specific vascular cadherin promoter (E-V290M), using nontransgenic littermates as controls...
September 2017: Hypertension
https://www.readbyqxmd.com/read/28666597/diet-quality-inflammation-and-the-ankle-brachial-index-in-adults-with-or-without-cardiometabolic-conditions
#19
Josiemer Mattei, Daniela Sotres-Alvarez, Marc Gellman, Sheila F Castañeda, Frank B Hu, Katherine L Tucker, Anna Maria Siega-Riz, Robert C Kaplan
BACKGROUND & AIMS: Diet quality may influence non-traditional cardiovascular disease (CVD) risk factors - namely, C-reactive protein (CRP) and the ankle-brachial index (ABI). Pre-existing traditional cardiometabolic conditions may confound this association. We aimed to determine whether diet quality was associated with high-risk CRP or ABI, independently from traditional cardiometabolic risk factors. METHODS: Baseline data were analyzed from US-Hispanics/Latinos aged 18-74 y without previously-diagnosed CVD participating in the population-based Hispanic Community Health Study/Study of Latinos cohort...
June 8, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28659407/an-empirical-dietary-inflammatory-pattern-score-enhances-prediction-of-circulating-inflammatory-biomarkers-in-adults
#20
COMPARATIVE STUDY
Fred K Tabung, Stephanie A Smith-Warner, Jorge E Chavarro, Teresa T Fung, Frank B Hu, Walter C Willett, Edward L Giovannucci
Background: Two indexes exist to describe dietary inflammatory potential: an empirical dietary inflammatory pattern (EDIP) composed of food groups as reported on a food-frequency questionnaire (FFQ) and a literature-derived dietary inflammatory index (DII) composed mainly of nutrients.Objective: We compared the ability of the 2 indexes to predict concentrations of inflammatory markers and hypothesized that the EDIP would be more predictive because it was derived on the basis of circulating inflammatory markers...
August 2017: Journal of Nutrition
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