Chang-Jun Lee, Song-Hee Lee, Beom-Seok Kang, Min-Kyu Park, Hyun-Wook Yang, Seo-Young Woo, Se-Wan Park, Dong-Yeon Kim, Hyun-Ho Jeong, Won-Il Yang, A-Ra Kho, Bo-Young Choi, Hong-Ki Song, Hui-Chul Choi, Yeo-Jin Kim, Sang-Won Suh
Epilepsy, marked by abnormal and excessive brain neuronal activity, is linked to the activation of L-type voltage-gated calcium channels (LTCCs) in neuronal membranes. LTCCs facilitate the entry of calcium (Ca2+ ) and other metal ions, such as zinc (Zn2+ ) and magnesium (Mg2+ ), into the cytosol. This Ca2+ influx at the presynaptic terminal triggers the release of Zn2+ and glutamate to the postsynaptic terminal. Zn2+ is then transported to the postsynaptic neuron via LTCCs. The resulting Zn2+ accumulation in neurons significantly increases the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, contributing to reactive oxygen species (ROS) generation and neuronal death...
March 24, 2024: Antioxidants (Basel, Switzerland)