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Cole R Drifka, Agnes G Loeffler, Kara Mathewson, Adib Keikhosravi, Jens C Eickhoff, Yuming Liu, Sharon M Weber, W John Kao, Kevin W Eliceiri
Risk factors for pancreatic ductal adenocarcinoma (PDAC) progression after surgery are unclear, and additional prognostic factors are needed to inform treatment regimens and therapeutic targets. PDAC is characterized by advanced sclerosis of the extracellular matrix, and interactions between cancer cells, fibrillar collagen, and other stromal components play an integral role in progression. Changes in stromal collagen alignment have been shown to modulate cancer cell behavior and have important clinical value in other cancer types, but little is known about its role in PDAC and prognostic value...
October 20, 2016: Oncotarget
S C Cifuentes, E Frutos, R Benavente, V Lorenzo, J L González-Carrasco
This work deals with the mechanical characterization by depth-sensing indentation (DSI) of PLLA and PLDA composites reinforced with micro-particles of Mg (up to 15wt%), which is a challenging task since the indented volume must provide information of the bulk composite, i.e. contain enough reinforcement particles. The composites were fabricated by combining hot extrusion and compression moulding. Physico-chemical characterization by TGA and DSC indicates that Mg anticipates the thermal degradation of the polymers but does not compromise their stability during processing...
September 21, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Iuliana Aprodu, Florentina-Mihaela Ursache, Mihaela Turturică, Gabriela Râpeanu, Nicoleta Stănciuc
Sea buckthorn has gained importance as a versatile nutraceutical, due to its high nutritive value in terms of carotenoids content. β-Lactoglobulin (β-LG) is a natural carrier for various bioactive compounds. In this study, the effect of thermal treatment in the temperature range of 25 to 100°C for 15min on the complex formed by β-LG and carotenoids from sea buckthorn was reported, based on fluorescence spectroscopy, molecular docking and molecular dynamics simulation results. Also, the berries extracts were analyzed for their carotenoids content...
October 17, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Chang-Gui Pan, You-Sheng Liu, Guang-Guo Ying
Perfluoroalkyl substances (PFASs) are a group of chemicals with wide industrial and commercial applications, and have been received great attentions due to their persistence in the environment. The information about their presence in urban water cycle is still limited. This study aimed to investigate the occurrence and removal efficiency of eighteen PFASs in wastewater treatment plants (WWTPs) and drinking water plants (DWTPs) with different treatment processes. The results showed that both perfluorobutane sulfonic acid (PFBS) and perfluorooctane sulfonic acid (PFOS) were the predominant compounds in the water phase of WWTPs and DWTPs, while PFOS was dominant in dewatered sludge of WWTPs...
October 19, 2016: Water Research
Nelly Rahkonen, Aki Stubb, Maia Malonzo, Sanna Edelman, Maheswara Reddy Emani, Elisa Närvä, Harri Lähdesmäki, Hannele Ruohola-Baker, Riitta Lahesmaa, Riikka Lund
MicroRNAs (miRNA) are central regulators of diverse biological processes and are important in the regulation of stem cell self-renewal. One of the widely studied miRNA-protein regulators is the Lin28-Let-7 pair. In this study, we demonstrate that contrary to the well-established models of mouse ES cells (mESC) and transformed human cancer cells, the pluripotent state of human ES cells (hESC) involves expression of mature Let-7 family miRNAs with concurrent expression of all LIN28 proteins. We show that mature Let-7 miRNAs are regulated during hESC differentiation and have opposite expression profile with LIN28B...
September 24, 2016: Stem Cell Research
E Auvinet, F Multon, V Manning, J Meunier, J P Cobb
Gait asymmetry information is a key point in disease screening and follow-up. Constant Relative Phase (CRP) has been used to quantify within-stride asymmetry index, which requires noise-free and accurate motion capture, which is difficult to obtain in clinical settings. This study explores a new index, the Longitudinal Asymmetry Index (ILong) which is derived using data from a low-cost depth camera (Kinect). ILong is based on depth images averaged over several gait cycles, rather than derived joint positions or angles...
August 24, 2016: Gait & Posture
Sarah C Boyle, Andrew M Earle, Joseph W LaBrie, Kayla Ballou
Studies examining representations of college drinking on social media have almost exclusively focused on Facebook. However, recent research suggests college students may be more influenced by peers' alcohol-related posts on Instagram and Snapchat, two image-based platforms popular among this demographic. One potential explanation for this differential influence is that qualitative distinctions in the types of alcohol-related content posted by students on these three platforms may exist. Informed by undergraduate focus groups, this study examined the hypothesis that, of the three platforms, students tend to use Instagram most often for photos glamourizing drinking and Snapchat for incriminating photos of alcohol misuse and negative consequences...
October 19, 2016: Addictive Behaviors
Simon Spalthoff, Rüdiger Zimmerer, Philipp Jehn, Nils-Claudius Gellrich, Jörg Handschel, Gertrud Krüskemper
PURPOSE: In this study of patients with oral squamous cell carcinoma, the authors sought to clarify the functional and psychosocial harms of neck dissection (ND), which lessens quality of life. MATERIALS AND METHODS: The study included questionnaire responses from patients with oral squamous cell carcinoma (n = 1,652) and clinicians (n = 1,489), as collected in the DÖSAK Rehab Study. Psychosocial and functional factors were assessed. Functional and psychosocial outcomes in patients who did not receive ND were compared with those in patients who underwent selective supraomohyoid ND (SND), modified radical ND (MND), and radical ND (RND)...
September 28, 2016: Journal of Oral and Maxillofacial Surgery
Thomas Schmidt, Alan J Situ, Tobias S Ulmer
The solvation of membrane proteins by both lipids and water makes their membrane immersion difficult to predict and the choice of a membrane mimic challenging. To characterize protein-lipid contacts and bicelle membrane mimics, we examined protein-lipid cross-relaxation of integrin αIIb and β3(A711P) transmembrane helices in isotropic phospholipid bicelles (q=0.5 and 0.7). Long-chain bicelle lipids dominated contacts with central helix segments, whereas both short- and long-chain lipids contacted the terminal turns of each helix in corroboration of the mixed bicelle model...
October 24, 2016: Journal of Physical Chemistry Letters
Martin Paparella, Annamaria Colacci, Miriam N Jacobs
An approach for a systematic description of the uncertainties and complexity of the standard animal testing and assessment approach for carcinogenicity is explored by using a draft OECD Guidance document that was originally developed for reporting defined in vitro approaches to testing and assessment (OECD, 2016). The format is suitable for this re-purposing and it appears that the potential multitude of approaches for integrating and interpreting data from standard animal testing may ultimately be conceptually similar to the challenge of integrating relevant in vitro and in silico data...
October 24, 2016: ALTEX
Amy E Barth, Amy Elleman
Purpose: We examined the effectiveness of a multistrategy inference intervention designed to increase inference making and reading comprehension for middle-grade struggling readers. Method: A total of 66 middle-grade struggling readers were randomized to treatment (n = 33) and comparison (n = 33) conditions. Students in the treatment group received explicit instruction in 4 inference strategies (i.e., clarification using text clues; activating and using prior knowledge; understanding character perspectives and author's purpose; answering inferential questions)...
October 24, 2016: Language, Speech, and Hearing Services in Schools
Cristian Torres-Díaz, Jorge Gallardo-Cerda, Paris Lavin, Rómulo Oses, Fernando Carrasco-Urra, Cristian Atala, Ian S Acuña-Rodríguez, Peter Convey, Marco A Molina-Montenegro
Most climate and environmental change models predict significant increases in temperature and precipitation by the end of the 21st Century, for which the current functional output of certain symbioses may also be altered. In this context we address the following questions: 1) How the expected changes in abiotic factors (temperature, and water) differentially affect the ecophysiological performance of the plant Colobanthus quitensis? and 2) Will this environmental change indirectly affect C. quitensis photochemical performance and biomass accumulation by modifying its association with fungal endophytes? Plants of C...
2016: PloS One
Ulrike Herberg, Katharina Linden, Oliver Dewald, Eva Gatzweiler, Matthias Seehase, Georg Daniel Duerr, Jonas Dörner, Stephanie Kleppe, Dennis Ladage, Johannes Breuer
BACKGROUND: Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data...
2016: PloS One
Yuko Okumura, Tessei Kobayashi, Shoji Itakura
Social cues in interaction with others enable infants to extract useful information from their environment. Although previous research has shown that infants process and retain different information about an object depending on the presence of social cues, the effect of eye contact as an isolated independent variable has not been investigated. The present study investigated how eye contact affects infants' object processing. Nine-month-olds engaged in two types of social interactions with an experimenter. When the experimenter showed an object without eye contact, the infants processed and remembered both the object's location and its identity...
2016: PloS One
Sandra Utz, Claus-Christian Carbon
Thompson (1980) first detected and described the Thatcher Illusion, where participants instantly perceive an upright face with inverted eyes and mouth as grotesque, but fail to do so when the same face is inverted. One prominent but controversial explanation is that the processing of configural information is disrupted in inverted faces. Studies investigating the Thatcher Illusion either used famous faces or non-famous faces. Highly familiar faces were often thought to be processed in a pronounced configural mode, so they seem ideal candidates to be tested in one Thatcher study against unfamiliar faces-but this has never been addressed so far...
2016: PloS One
Bing Zheng, Jun Liu, Jianlei Gu, Jing Du, Lin Wang, Shengli Gu, Juan Cheng, Jun Yang, Hui Lu
BACKGROUND: A key challenge in thyroid carcinoma is preoperatively diagnosing malignant thyroid nodules. A novel diagnostic test that measures the expression of a 3-gene signature (DPP4, SCG5 and CA12) has demonstrated promise in thyroid carcinoma assessment. However, more reliable prediction methods combining clinical features with genomic signatures with high accuracy, good stability and low cost are needed. METHODOLOGY/PRINCIPAL FINDINGS: 25 clinical information were recorded in 771 patients...
2016: PloS One
Michael F Regner, Naomi Saenz, Keeran Maharajh, Dorothy J Yamamoto, Brianne Mohl, Korey Wylie, Jason Tregellas, Jody Tanabe
OBJECTIVE: We hypothesized that compared to healthy controls, long-term abstinent substance dependent individuals (SDI) will differ in their effective connectivity between large-scale brain networks and demonstrate increased directional information from executive control to interoception-, reward-, and habit-related networks. In addition, using graph theory to compare network efficiencies we predicted decreased small-worldness in SDI compared to controls. METHODS: 50 SDI and 50 controls of similar sex and age completed psychological surveys and resting state fMRI...
2016: PloS One
Arianna Rubin Means, Julie Jacobson, Aryc W Mosher, Judd L Walson
BACKGROUND: While some evidence supports the beneficial effects of integrating neglected tropical disease (NTD) programs to optimize coverage and reduce costs, there is minimal information regarding when or how to effectively operationalize program integration. The lack of systematic analyses of integration experiences and of integration processes may act as an impediment to achieving more effective NTD programming. We aimed to learn about the experiences of NTD stakeholders and their perceptions of integration...
October 2016: PLoS Neglected Tropical Diseases
Antoun Nader, Mark C Kendall, David W Manning, Matthew Beal, Rohit Rahangdale, Robert Dekker, Gildasio S De Oliveira, Eric Kamenetsky, Robert J McCarthy
BACKGROUND AND OBJECTIVES: A single-dose adductor canal block can provide postoperative analgesia for patients undergoing total knee arthroplasty (TKA). The purpose of this study was to assess postoperative opioid consumption after ultrasound-guided single-injection bupivacaine compared with saline adductor canal block for patients undergoing TKA. METHODS: After institutional review board approval, written informed consent was obtained from patients (>18 years old) undergoing elective TKA...
November 2016: Regional Anesthesia and Pain Medicine
Tian Gan, Liming Wang, Lisha Zhang, Wei Fang, Ruolei Gu
This study used the event-related potential technique to explore the neural correlates of outcome evaluation about helping others during a decision task. The results showed that the amplitude of feedback-related negativity elicited by 'failed outcome' (indicating a failure in helping others) was larger than that elicited by 'successful outcome' (indicating a success in helping others). Failed outcome also elicited a larger and longer P300 than successful outcome. The feedback-related negativity and P300 reflect the automatic process in an early stage and the control process in a late stage of outcome evaluation, respectively...
December 7, 2016: Neuroreport
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