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Ustekinumab crohn's

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https://www.readbyqxmd.com/read/28329588/ustekinumab-for-treatment-of-cutaneous-crohn-s-disease
#1
Rana Abdat, Alina Markova, Francis A Farraye, Michael K Lichtman
Cutaneous Crohn disease (CD) affecting the vulva, perineum, and perianal skin, is a rare entity, which may accompany or precede gastrointestinal CD. Vulvar involvement, if untreated, may ultimately require extensive surgery including vulvectomy to gain control of the disease. Both gastrointestinal and cutaneous CD respond to biologics, which block TNF. In addition, ustekinumab, which targets both IL-12 and IL-23 cytokines, is effective in patients with gastrointestinal CD who fail TNF blockade. However, it is unclear if ustekinumab is effective for cutaneous CD...
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328624/long-term-maintenance-of-clinical-endoscopic-and-radiographic-response-to-ustekinumab-in-moderate-to-severe-crohn-s-disease-real-world-experience-from-a-multicenter-cohort-study
#2
Christopher Ma, Richard N Fedorak, Gilaad G Kaplan, Levinus A Dieleman, Shane M Devlin, Nathan Stern, Karen I Kroeker, Cynthia H Seow, Yvette Leung, Kerri L Novak, Brendan P Halloran, Vivian W Huang, Karen Wong, Philip K Blustein, Subrata Ghosh, Remo Panaccione
BACKGROUND: Ustekinumab is a monoclonal antibody targeting interleukins 12 and 23. While effective in clinical trials for Crohn's disease (CD), long-term maintenance of response in the real-world setting is unclear. We aim to assess the efficacy of ustekinumab for maintaining clinical, endoscopic, and radiographic response in CD. METHODS: A retrospective multicenter cohort study was performed on patients with CD achieving steroid-free clinical response to ustekinumab induction, and advanced onto a regularly scheduled maintenance ustekinumab regimen between 2011 and 2016...
March 21, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28321458/-erratum-to-ustekinumab-for-the-treatment-of-crohn-s-disease-uniti-im-uniti
#3
B Siegmund, S Nitschmann
No abstract text is available yet for this article.
March 20, 2017: Der Internist
https://www.readbyqxmd.com/read/28252210/clinical-endoscopic-and-radiographic-outcomes-with-ustekinumab-in-medically-refractory-crohn-s-disease-real-world-experience-from-a-multicentre-cohort
#4
C Ma, R N Fedorak, G G Kaplan, L A Dieleman, S M Devlin, N Stern, K I Kroeker, C H Seow, Y Leung, K L Novak, B P Halloran, V W Huang, K Wong, P K Blustein, S Ghosh, R Panaccione
BACKGROUND: Ustekinumab is a monoclonal antibody targeting interleukins-12 and -23, with efficacy in Crohn's disease (CD) demonstrated in clinical trials. AIM: To assess the real-world clinical, endoscopic and radiographic response and remission outcomes achieved with ustekinumab in medically-refractory CD. METHODS: A retrospective multicentre cohort study was performed on CD patients receiving ustekinumab between 2011 and 2016. The primary outcome was achievement of clinical and objective steroid-free response and remission at 3, 6 and 12 months...
March 2, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28247573/review-article-moving-towards-common-therapeutic-goals-in-crohn-s-disease-and-rheumatoid-arthritis
#5
REVIEW
P B Allen, P Olivera, P Emery, D Moulin, J-Y Jouzeau, P Netter, S Danese, B Feagan, W J Sandborn, L Peyrin-Biroulet
BACKGROUND: Crohn's disease (CD) and rheumatoid arthritis are chronic, progressive and disabling conditions that frequently lead to structural tissue damage. Based on strategies originally developed for rheumatoid arthritis, the treatment goal for CD has recently moved from exclusively controlling symptoms to both clinical remission and complete mucosal healing (deep remission), with the final aim of preventing bowel damage and disability. AIM: To review the similarities and differences in treatment goals between CD and rheumatoid arthritis...
March 1, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28204858/-ustekinumab-for-the-treatment-of-crohn-s-disease-uniti-im-uniti
#6
B Siegmund, S Nitschmann
No abstract text is available yet for this article.
February 15, 2017: Der Internist
https://www.readbyqxmd.com/read/28179246/legionella-pneumophila-pneumonia-possibly-due-to-ustekinumab-therapy-in-a-patient-with-crohn-s-disease
#7
Joaquín Borrás-Blasco, Xavier Cortes, Sergio Fernandez-Martinez, Elvira Casterá, Beatriz Antequera
PURPOSE: A case report of Legionella pneumophila pneumonia associated with off-label use of ustekinumab in a patient with Crohn's disease (CD) is presented. SUMMARY: A 57-year-old man with longstanding CD was hospitalized with a four-day history of fever (38.5 °C), dyspnea, left pleuritic pain, and weight loss (more than 6 kg) about six weeks after beginning treatment with ustekinumab, a human monoclonal antibody approved in the United States for two indications (plaque psoriasis and psoriatic arthritis) and currently under investigation as a potential treatment for CD and other inflammatory disorders...
February 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28175164/p594-ustekinumab-treatment-effectiveness-in-clinical-practice-a-multicentre-retrospective-review-of-long-term-outcomes-in-crohn-s-disease
#8
C R Rowan, A Alakkari, C Moran, J O'Connell, G Cullen, H Mulcahy, C O'Morain, D McNamara, J Leyden, P MacMathuna, A O'Toole, S Patchett, S McKiernan, D Kevans, G A Doherty, B Ryan
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175158/p626-ustekinumab-for-the-treatment-of-perianal-fistulas-in-patients-with-crohn-s-disease
#9
R Battat, T Bessissow, M Strohl, U Kopylov, A Bitton, A Cohen, E Seidman, W Afif
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175147/p549-effect-of-maintenance-ustekinumab-on-corticosteroid-free-clinical-outcomes-in-patients-with-crohn-s-disease
#10
B G Feagan, C Gasink, P Pollack, D Jacobstein, L-L Gao, J Johanns, Y Miao, S Targan, S Ghosh
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175098/p360-trough-levels-and-antibodies-to-ustekinumab-are-not-correlated-to-response-to-ustekinumab-treatment-in-crohn-s-disease-patients
#11
P Claire, B Severine, D Nicolas, N Maria, D Pierre, B Julien, G Romain, B Medina, L Myriam, P Benjamin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174962/dop053-the-fecal-microbiome-as-a-tool-for-monitoring-and-predicting-response-outcomes-in-ustekinumab-treated-anti-tnf%C3%AE-refractory-crohn-s-disease-patients-results-from-the-certifi-study
#12
M K Doherty, C Koumpouras, S E Telesco, C Monast, C Brodmerkel, P D Schloss
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174941/dop052-molecular-response-to-ustekinumab-in-moderate-to-severe-crohn-s-disease-by-serum-protein-and-biopsy-gene-expression-analysis-results-from-ustekinumab-phase-3-studies
#13
K Li, K Hayden, E Wadman, S Bhagat, S Emrich, D Jacobstein, C Gasink, C Brodmerkel
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174928/dop046-genome-wide-association-study-of-baseline-disease-characteristics-and-response-to-ustekinumab-in-moderate-to-severe-crohn-s-disease
#14
A Hart, K Li, C Gasink, D Jacobstein, C Brodmerkel
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174927/dop027-long-term-efficacy-and-safety-of-ustekinumab-in-refractory-crohn-s-disease-patients-a-multicenter-retrospective-experience
#15
P Wils, Y Bouhnik, P Michetti, B Flourie, H Brixi, A Bourrier, M Allez, B Duclos, M Serrero, A Buisson, A Amiot, M Fumery, X Roblin, L Peyrin-Biroulet, J Filippi, G Bouguen, V Abitbol, B Coffin, M Simon, D Laharie, B Pariente
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173013/p597-ustekinumab-use-in-crohn-s-disease-a-tertiary-centre-experience
#16
A Greenup, G Rosenfeld, B Bressler
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172810/p625-ustekinumab-use-in-crohn-s-disease-effectiveness-of-dose-escalation
#17
A Greenup, G Rosenfeld, B Bressler
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172686/op010-long-term-efficacy-and-safety-of-ustekinumab-for-crohn-s-disease-results-from-im-uniti-long-term-extension-through-2-years
#18
W Sandborn, P Rutgeerts, C Gasink, D Jacobstein, L-L Gao, J Johanns, B Sands, S B Hanauer, S Targan, S Ghosh, W J S de Villiers, J-F Colombel, B G Feagan
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172546/p588-ustekinumab-for-the-treatment-of-crohn-s-disease-patients-with-tnf-antagonist-induced-psoriasis-real-life-experience-from-a-tertiary-referral-center-through-week-54
#19
T Kuehbacher, R Abu Hashem, N Langel, S Schreiber, O Drvarov
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172536/p465-efficacy-of-ustekinumab-for-induction-and-maintenance-of-histological-healing-in-patients-with-crohn-s-disease
#20
K Li, D Chan, P Pollack, D Jacobstein, C Brodmerkel, C Gasink, B G Feagan, W Sandborn, P Rutgeerts, G De Hertogh
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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