keyword
https://read.qxmd.com/read/38536788/a-dual-computational-and-experimental-strategy-to-enhance-tslp-antibody-affinity-for-improved-asthma-treatment
#1
JOURNAL ARTICLE
Yitong Lv, He Gong, Xuechao Liu, Jia Hao, Lei Xu, Zhiwei Sun, Changyuan Yu, Lida Xu
Thymic stromal lymphopoietin is a key cytokine involved in the pathogenesis of asthma and other allergic diseases. Targeting TSLP and its signaling pathways is increasingly recognized as an effective strategy for asthma treatment. This study focused on enhancing the affinity of the T6 antibody, which specifically targets TSLP, by integrating computational and experimental methods. The initial affinity of the T6 antibody for TSLP was lower than the benchmark antibody AMG157. To improve this, we utilized alanine scanning, molecular docking, and computational tools including mCSM-PPI2 and GEO-PPI to identify critical amino acid residues for site-directed mutagenesis...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38533367/co-occurrence-of-otitis-media-with-effusion-and-another-environment-dependent-disease-selected-allergic-conditions
#2
JOURNAL ARTICLE
Oksana Wojas, Edyta Krzych-Fałta, Konrad Furmańczyk, Diana Dziewa-Dawidczyk, Bolesław Samoliński, Piotr Samel-Kowalik
INTRODUCTION: Otitis media eith effusion (OME) is an inflammatory condition of the middle ear that involves accumulation of sterile fluid or effusion in the tympanic cavity with the tympanic membrane intact. The pathophysiology of OME is undoubtedly multifactorial. AIM: To assess the co-occurrence of OME, allergic rhinitis, and asthma. MATERIAL AND METHODS: The study involved a group of 18,617 subjects aged 6-7 years, 13-14 years, or 20-44 years...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533360/clinical-relevance-of-cluster-analysis-in-phenotyping-allergic-rhinitis-in-the-paediatric-population-of-the-kuyavian-pomeranian-voivodeship-poland
#3
JOURNAL ARTICLE
Agnieszka Kowalczyk, Aneta Krogulska
INTRODUCTION: Allergic rhinitis (AR) is the most common allergic disease in the world, and additionally, its prevalence is successively increasing. Children with AR constitute a heterogeneous group of patients differing both in the course of AR and in the frequency of asthma coexistence. It is possible to identify children with AR at risk of a more severe course of the disease by analysing the potential family, environmental and clinical factors related to the development of the disease; the findings will help identify patients with a higher risk of developing asthma in the future, and who will benefit the most from early allergen-specific immunotherapy...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533354/history-of-pollutant-adjuvants-in-respiratory-allergy
#4
REVIEW
Dennis Shusterman
Combined exposures to allergens and air pollutants emerged as a topic of concern in scientific circles by the 1980's, when it became clear that parallel increases in respiratory allergies and traffic-related air pollution had been occurring during the 20th century. Although historically there has been a tendency to treat exposure-related symptoms as either allergic or toxicologic in nature, cross-interactions have since been established between the two modalities. For example, exposure to selected air pollutants in concert with a given allergen can increase the likelihood that an individual will become sensitized to that allergen, strongly suggesting that the pollutant acted as an adjuvant ...
2024: Front Allergy
https://read.qxmd.com/read/38530239/piezo1-channels-restrain-ilc2s-and-regulate-the-development-of-airway-hyperreactivity
#5
JOURNAL ARTICLE
Benjamin P Hurrell, Stephen Shen, Xin Li, Yoshihiro Sakano, Mohammad Hossein Kazemi, Christine Quach, Pedram Shafiei-Jahani, Kei Sakano, Homayon Ghiasi, Omid Akbari
Mechanosensitive ion channels sense force and pressure in immune cells to drive the inflammatory response in highly mechanical organs. Here, we report that Piezo1 channels repress group 2 innate lymphoid cell (ILC2)-driven type 2 inflammation in the lungs. Piezo1 is induced on lung ILC2s upon activation, as genetic ablation of Piezo1 in ILC2s increases their function and exacerbates the development of airway hyperreactivity (AHR). Conversely, Piezo1 agonist Yoda1 reduces ILC2-driven lung inflammation. Mechanistically, Yoda1 inhibits ILC2 cytokine secretion and proliferation in a KLF2-dependent manner, as we found that Piezo1 engagement reduces ILC2 oxidative metabolism...
May 6, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38530238/the-human-mif-polymorphism-catt-7-enhances-pro-inflammatory-macrophage-polarization-in-a-clinically-relevant-model-of-allergic-airway-inflammation
#6
JOURNAL ARTICLE
Hazel Dunbar, Ian J Hawthorne, Eóin N McNamee, Michelle E Armstrong, Seamas C Donnelly, Karen English
High level expression of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has been associated with severe asthma. The role of MIF and its functional promotor polymorphism in innate immune training is currently unknown. Using novel humanized CATT7 MIF mice, this study is the first to investigate the effect of MIF on bone marrow-derived macrophage (BMDM) memory after house dust mite (HDM) challenge. CATT7 BMDMs demonstrated a significant primed increase in M1 markers following HDM and LPS stimulation, compared to naive mice...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38529710/sq-sublingual-immunotherapy-tablets-for-children-with-allergic-rhinitis-a-review-of-phase-three-trials
#7
REVIEW
Péter Csonka, Eckard Hamelmann, Mirjana Turkalj, Graham Roberts, Douglas P Mack
AIM: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebo-controlled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. METHODS: PubMed searches were conducted and unpublished data were included if necessary. RESULTS: Of the 93 publications, 12 were identified reporting 10 trials...
March 26, 2024: Acta Paediatrica
https://read.qxmd.com/read/38529288/comprehensive-analysis-of-lung-macrophages-and-dendritic-cells-in-two-murine-models-of-allergic-airway-inflammation-reveals-model-and-subset-specific-accumulation-and-phenotypic-alterations
#8
JOURNAL ARTICLE
Belinda Camp, Ilka Jorde, Franka Sittel, Alexander Pausder, Andreas Jeron, Dunja Bruder, Jens Schreiber, Sabine Stegemann-Koniszewski
INTRODUCTION: Allergic asthma has been mainly attributed to T helper type 2 (Th2) and proinflammatory responses but many cellular processes remain elusive. There is increasing evidence for distinct roles for macrophage and dendritic cell (DC) subsets in allergic airway inflammation (AAI). At the same time, there are various mouse models for allergic asthma that have been of utmost importance in identifying key inflammatory pathways in AAI but that differ in the allergen and/or route of sensitization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528652/the-contribution-of-the-wnt-pathway-to-the-therapeutic-effects-of-montelukast-in-experimental-murine-airway-inflammation-induced-by-ovalbumin-and-lipopolysaccharide
#9
JOURNAL ARTICLE
Yesim Kaya-Yasar, Seckin Engin, Elif Nur Barut, Cihan Inan, Ismail Saygin, Ilknur Erkoseoglu, Sena F Sezen
The wingless/integrase-1 (WNT) pathway involved in the pathogenesis of inflammatory airway diseases has recently generated considerable research interest. Montelukast, a leukotriene receptor antagonist, provides therapeutic benefits in allergic asthma involving eosinophils. We aimed to investigate the role of the WNT pathway in the therapeutic actions of montelukast (MT) in a mixed type of allergic-acute airway inflammation model induced by ovalbumin (OVA) and lipopolysaccharide (LPS) in mice. Female mice were sensitized with intraperitoneal OVA-Al(OH)3 administration in the initiation phase and intranasal OVA followed by LPS administration in the challenge phase...
April 2024: Drug Development Research
https://read.qxmd.com/read/38528383/postpartum-maternal-anxiety-affects-the-development-of-food-allergy-through-dietary-and-gut-microbial-diversity-during-early-infancy
#10
JOURNAL ARTICLE
Hyunbin Cho, Jiwon Kim, Sukyung Kim, Hye-In Jeong, Mijeong Kwon, Hyun Mi Kim, Ji Sun Shim, Kyunga Kim, Jihyun Baek, Yechan Kyung, Suk-Joo Choi, Soo-Young Oh, Jaewoong Bae, Hong-Hee Won, Jihyun Kim, Kangmo Ahn
PURPOSE: We aimed to investigate the mediating factors between maternal anxiety and the development of food allergy (FA) in children until 2 years from birth. METHODS: In this longitudinal cohort of 122 mother-child dyads from pregnancy to 24 months of age, we regularly surveyed maternal psychological states, infant feeding data, and allergic symptoms and collected stool samples at 6 months of age for microbiome analysis. Considering the temporal order of data collection, we investigated serial mediating effects and indirect effects among maternal anxiety, dietary diversity (DD), gut microbial diversity, and FA using structural equation modeling...
March 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38527438/demethylzeylasteral-t-96-alleviates-allergic-asthma-via-inhibiting-mapk-erk-and-nf-%C3%AE%C2%BAb-pathway
#11
JOURNAL ARTICLE
Jianan Huang, Hui Cai, Xiaofen Ye, Ge Zhang, Ling Ye, Chunxin Yang, Jian Wang, Meiling Jin
INTRODUCTION: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the protective effect and underlying mechanism of T-96 in allergic asthma. METHODS: The OVA-induced asthmatic mice were administered by gavage with T-96 (0.1 mg/10 g, 0.3 mg/10 g, or 0.6 mg/10 g) 1 h before each challenge. The airway hyperresponsiveness was assessed, pathological changes were evaluated by HE and PAS staining, and expressions of Th2 cytokines were determined by PCR and ELISA...
March 25, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38527432/-air-that-once-was-breath-part-2-wildfire-smoke-and-airway-disease-climate-change-allergy-and-immunology-special-iaai-article-collection-collegium-internationale-allergologicum-update-2023
#12
REVIEW
Willis S Bowman, Rebecca J Schmidt, Gursharan K Sanghar, George R Thompson Iii, Hong Ji, Amir A Zeki, Angela Haczku
BACKGROUND: Population growth and climate change have led to more frequent and larger wildfires, increasing the exposure of individuals to wildfire smoke. Notably, asthma exacerbations and allergic airway sensitization are prominent outcomes of such exposure. SUMMARY: Key research questions relate to determining the precise impact on individuals with asthma, including the severity, duration, and long-term consequences of exacerbations. Identifying specific risk factors contributing to vulnerability, such as age, genetics, comorbidities, or environmental factors, is crucial...
March 25, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38527402/up-regulation-of-hsp90%C3%AE-in-hdm-induced-asthma-causes-pyroptosis-of-airway-epithelial-cells-by-activating-the-cgas-sting-er-stress-pathway
#13
JOURNAL ARTICLE
Haohua Huang, Yujie Qiao, Lanhe Chu, Cuiping Ye, Lishan Lin, Hua Liao, Xiaojing Meng, Fei Zou, Haijin Zhao, Mengchen Zou, Shaoxi Cai, Hangming Dong
Heat Shock protein 90 α (HSP90α), an main subtype of chaperone protein HSP90, involves important biological functions such as DNA damage repair, protein modification, innate immunity. However, the potential role of HSP90α in asthma occurrence and development is still unclear. This study aimed to elucidate the underlying mechanism of HSP90α in asthma by focusing on the cGAS-STING-Endoplasmic Reticulum stress pathway in inflammatory airway epithelial cell death (i.e., pyroptosis; inflammatory cell death)...
March 24, 2024: International Immunopharmacology
https://read.qxmd.com/read/38524785/covid-19-vaccine-uptake-among-young-adults-influence-of-asthma-and-sociodemographic-factors
#14
JOURNAL ARTICLE
Maria Ödling, Niklas Andersson, Sandra Ekström, Niclas Roxhed, Jochen M Schwenk, Sophia Björkander, Anna Bergström, Erik Melén, Inger Kull
BACKGROUND: Asthma was initially described as a risk factor for severe coronavirus disease 2019 (COVID-19), but the uptake of COVID-19 vaccine among young adults with asthma is not well studied. OBJECTIVE: The aims were to assess COVID-19 vaccine uptake among young adults in general and to explore potential determinants including sociodemographic factors and asthma. METHODS: Participants from the population-based birth cohort BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) were included: 4,064 in the study population, 3,064 in a follow-up at age 24 years, and 2,049 in a COVID-19 follow-up (mean age, 26...
May 2024: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/38524099/tezepelumab-for-severe-asthma-one-drug-targeting-multiple-disease-pathways-and-patient-types
#15
REVIEW
Reynold Panettieri, Njira Lugogo, Jonathan Corren, Christopher S Ambrose
Asthma is a heterogeneous inflammatory disease of the airways, affecting many children, adolescents, and adults worldwide. Up to 10% of people with asthma have severe disease, associated with a higher risk of hospitalizations, greater healthcare costs, and poorer outcomes. Patients with severe asthma generally require high-dose inhaled corticosteroids and additional controller medications to achieve disease control; however, many patients remain uncontrolled despite this intensive treatment. The treatment of severe uncontrolled asthma has improved with greater understanding of asthma pathways and phenotypes as well as the advent of targeted biologic therapies...
2024: Journal of Asthma and Allergy
https://read.qxmd.com/read/38523669/the-clinical-burden-of-food-allergies-insights-from-the-food-allergy-research-education-fare-patient-registry
#16
JOURNAL ARTICLE
Christopher Warren, Ruchi Gupta, Arpamas Seetasith, Robert Schuldt, Rongrong Wang, Ahmar Iqbal, Sachin Gupta, Thomas B Casale
BACKGROUND: Food allergies are serious and potentially life-threatening, and often place a large burden on patients and their caregivers, including impacts on quality of life. OBJECTIVE: To assess the real-world patient burden of food allergies, using self-reported data available from the Food Allergy Research & Education (FARE) Patient Registry (NCT04653324). METHODS: The FARE Patient Registry is voluntary and captures real-world experiences of adults and pediatric patients in the United States, and their caregivers, through a series of surveys assessing patient health and experiences with food allergies...
March 2024: World Allergy Organization Journal
https://read.qxmd.com/read/38521900/increased-di-2-ethylhexyl-phthalate-exposure-poses-a-differential-risk-for-adult-asthma-clusters
#17
JOURNAL ARTICLE
Yuan-Ting Hsu, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Yi-Hsin Yang, Ming-Yen Cheng, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Yung-Fa Lai, Meng-Hsuan Cheng, Huang-Chi Chen, Chih-Jen Yang, Chien-Jen Wang, Huei-Ju Liu, Hua-Ling Chen, Chih-Hsing Hung, Chon-Lin Lee, Ming-Shyan Huang, Shau-Ku Huang
BACKGROUND: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology. METHODS: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions...
March 23, 2024: Respiratory Research
https://read.qxmd.com/read/38521452/atopic-dermatitis-in-early-childhood-and-risk-of-inflammatory-bowel-disease-a-scandinavian-birth-cohort-study
#18
JOURNAL ARTICLE
Tereza Lerchova, Ketil Størdal, Björn Andersson, Johnny Ludvigsson, Karl Mårild
OBJECTIVE: To examine the association between early-life atopic manifestations and later risk of inflammatory bowel disease (IBD), for which prospective data are scarce. STUDY DESIGN: The population-based All Babies in Southeast Sweden (ABIS) and Norwegian Mother, Father, and Child (MoBa) cohorts follow children from birth (ABIS 1997-1999; MoBa 2000-2009) to the end of 2021. Based on validated questionnaires, parents prospectively reported information on asthma, food-related allergic symptoms, atopic dermatitis, and allergic rhinitis by age 3...
March 21, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38520686/bronchiectasis-severity-index-and-faced-scores-in-patients-with-allergic-bronchopulmonary-aspergillosis-complicating-asthma-do-they-correlate-with-immunological-severity-or-high-attenuation-mucus
#19
JOURNAL ARTICLE
Shruti Phadnis, Valliappan Muthu, Inderpaul S Sehgal, Kuruswamy T Prasad, Sahajal Dhooria, Ashutosh N Aggarwal, Ritesh Agarwal
Background: The utility of two disease-severity indices, namely bronchiectasis severity index (BSI) and FACED score in allergic bronchopulmonary aspergillosis (ABPA) remains unknown. Objective: To correlate the BSI and FACED scores with immunological parameters (serum IgE [total and A. fumigatus -specific], A. fumigatus -specific IgG, blood eosinophil count), and high-attenuation mucus on chest computed tomography in ABPA. The secondary objectives were to evaluate the correlation between BSI and FACED scores and correlate the BSI/FACED scores with the bronchiectasis health questionnaire (BHQ) and Saint George's Respiratory Questionnaire (SGRQ)...
March 23, 2024: Journal of Asthma
https://read.qxmd.com/read/38519555/association-of-factors-with-childhood-asthma-and-allergic-diseases-using-latent-class-analysis
#20
JOURNAL ARTICLE
Teresa To, Cornelia M Borkhoff, Laura N Anderson, Catherine S Birken, Sharon D Dell, Magdalena Janus, Jonathon L Maguire, Theo J Moraes, Patricia C Parkin, Padmaja Subbarao, Anne Van Dam, Beverly Guttman, Emilie Terebessy, Kimball Zhang, Jingqin Zhu
We hypothesize that children characterized by deprived factors have poorer health outcomes. We aim to identify clustering of determinants and estimate risk of early childhood diseases. This 1993-2019 longitudinal cohort study combines three Canadian pediatric cohorts and their families. Mothers and children are clustered using latent class analysis (LCA) by 16 indicators in three domains (maternal and newborn; socioeconomic status [SES] and neighbourhood; environmental exposures). Hazard ratios (HR) of childhood asthma, allergic rhinitis (AR), and eczema are quantified with Cox proportional hazard (PH) regression...
March 22, 2024: Scientific Reports
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