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https://www.readbyqxmd.com/read/28346935/dysbiosis-in-the-neonatal-period-role-of-cesarean-section
#1
Josef Neu
From epidemiological studies and studies done evaluating microbiomes in infants, there is a strong signal that the infants born by elective cesarean section (C-section) develop microbiota that differs from those babies born by vaginal delivery. Epidemiological studies show increased odds ratios for the development of immunological disorders such as type 1 diabetes, celiac disease, asthma, allergic diseases as well as metabolic diseases such as obesity in babies born by C-section. These are interesting associations, and if supported by additional studies that rigorously control for confounding factors, they will have major public health implications...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346234/outstanding-animal-studies-in-allergy-i-from-asthma-to-food-allergy-and-anaphylaxis
#2
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed. RECENT FINDINGS: While domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results...
March 24, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28346024/increased-il-4-and-il-17-producing-cd8-cells-are-related-to-decreased-cd39-cd4-foxp3-cells-in-allergic-asthma
#3
Li Ping, Zhen Yang, Qin Zhang, Wei Wang, Jiong Yang
OBJECTIVE: In allergic asthma, regulatory T cell (Treg) number and function are decreased. Antigen primed CD8(+) T cells play an indispensable role in the full development of airway inflammation and airway hyper-responsiveness (AHR) occurring in asthma. In this study, we investigated the relationship between subpopulations of CD8(+) T cells and CD39(+) Tregs. METHODS: Female C57BL/6 mice were used to develop the model of allergic asthma. Experimental mice were immunized with ovalbumin (OVA) by intra-peritoneal (i...
March 27, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28345180/population-based-study-shows-that-teenage-girls-with-asthma-had-impaired-health-related-quality-of-life
#4
Linnea Hedman, Caroline Stridsman, Martin Andersson, Helena Backman, Sven-Arne Jansson, Eva Rönmark
AIM: This study examined the health-related quality of life (HRQoL) of teenagers with and without asthma, including the impact of their sex, allergic conditions, smoking, living conditions and physical activity. METHODS: The Obstructive Lung Disease in Northern Sweden (OLIN) studies recruited a cohort of schoolchildren in 2006. The parents of all children aged 7-8 years in three municipalities were invited to complete a questionnaire and 2,585 (96%) participated...
March 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28343320/allergic-airway-inflammation-induces-migration-of-mast-cell-populations-into-the-mouse-airway
#5
David Schmit, Duc Dung Le, Sebastian Heck, Markus Bischoff, Thomas Tschernig, Christian Herr, Christoph Beisswenger, Peter Kobelt, Phillipp Moritz Lepper, Kian Fan Chung, Robert Bals, Quoc Thai Dinh
Mast cells (MCs) and airway nerves play an important role in allergic asthma. However, little is known about the MCs and their interaction with airway nerves during allergic airway inflammation. This study aims to investigate the distribution and proliferation of MC populations in different lung compartments, along with the association of mast cells with nerve endings, using a house dust mite (HDM) model for allergic airway inflammation. BALB/c mice were exposed to HDM extract intranasally (25 μg/50 μl) for 5 consecutive days a week over 7 weeks...
March 25, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28342859/hydroethanolic-extract-from-echinodorus-scaber-rataj-leaves-inhibits-inflammation-in-ovalbumin-induced-allergic-asthma
#6
Suellen Iara Guirra Rosa, Fabrício Rios-Santos, Sikiru Olaitan Balogun, Danielle Ayr Tavares de Almeida, Amilcar Sabino Damazo, Thais Campos Dias da Cruz, Eduarda Pavan, Robson Dos Santos Barbosa, Tarso da Costa Alvim, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Antonio Macho, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Echinodorus scaber, Alismataceae, is popularly known in Brazil as "chapéu-de-couro". The plant leaves are used by the population as decoction, infusion, or maceration in bottled spirits, to treat inflammatory respiratory diseases. AIM OF THE STUDY: To investigate the anti-inflammatory mechanism of the hydroethanolic extract of leaves of Echinodorus scaber (HEEs) in allergic asthma. A phytochemical analysis of the extract was performed as well...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28342137/skewed-exposure-to-environmental-antigens-complements-hygiene-hypothesis-in-explaining-the-rise-of-allergy
#7
Wilfried Allaerts, Tse Wen Chang
The Hygiene Hypothesis has been recognized as an important cornerstone to explain the sudden increase in the prevalence of asthma and allergic diseases in modernized culture. The recent epidemic of allergic diseases is in contrast with the gradual implementation of Homo sapiens sapiens to the present-day forms of civilization. This civilization forms a gradual process with cumulative effects on the human immune system, which co-developed with parasitic and commensal Helminths. The clinical manifestation of this epidemic, however, became only visible in the second half of the twentieth century...
March 24, 2017: Acta Biotheoretica
https://www.readbyqxmd.com/read/28341882/lifetime-allergic-rhinitis-prevalence-among-us-primary-farm-operators-findings-from-the-2011-farm-and-ranch-safety-survey
#8
Jacek M Mazurek, Paul K Henneberger
PURPOSE: Allergic rhinitis is associated with decreased quality of life, and reduced workplace performance and productivity. This study investigated the prevalence of lifetime allergic rhinitis and factors associated with allergic rhinitis among US primary farm operators. METHODS: The 2011 Farm and Ranch Safety Survey data collected from 11,210 active farm operators were analyzed. Survey respondents were determined to have lifetime allergic rhinitis based on a "yes" response to the question: "Have you ever been told by a doctor, nurse, or other health professional that you had hay fever, seasonal allergies, or allergic rhinitis?" Data were weighted to produce nationally representative estimates...
March 24, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28341820/il-23-gene-and-protein-expression-in-childhood-asthma
#9
Soheila Alyasin, Reza Amin, Ali Fazel, Mohammad Hossein Karimi, Seyed Hesamedin Nabavizadeh, Hossein Esmaeilzadeh, Maryam Babaei
BACKGROUND: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adult allergic asthma has been studied. OBJECTIVE: To explore IL-23 serum levels and its expression in persistent asthma compared with healthy children younger than five years old...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341172/comparison-of-pediatric-and-adult-systemic-reactions-to-subcutaneous-immunotherapy
#10
Chen E Lim, Cristina P Sison, Punita Ponda
BACKGROUND: Subcutaneous immunotherapy (SCIT) has been used to treat allergic rhinitis for over a century, and current regimens have wide variability with an array of practice styles and dosing strategies. Although there are some statements about contraindications and cautions, no specific formal age- or weight-based dosing guidelines are utilized when administering SCIT. OBJECTIVE: The primary objective of this study was to estimate the overall incidence rate of any reaction to SCIT and to consider the severity of the reaction by grade in children and adults...
March 21, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28340863/serum-cytokine-profiles-as-predictors-of-asthma-control-in-adults-from-the-egea-study
#11
Zeina Akiki, Marta Rava, Oscar Diaz Gil, Isabelle Pin, Nicole le Moual, Valérie Siroux, Stefano Guerra, Soulaima Chamat, Regis Matran, Montserrat Fitó, Pascale Salameh, Rachel Nadif
BACKGROUND: To which extent serum cytokines may predict asthma control in adults remains understudied. OBJECTIVES: We investigated cross-sectional and longitudinal associations between cytokine profiles and asthma outcomes. METHODS: Serum interleukin (IL)-1Ra, IL-5, IL-7, IL-8, IL-10, IL-13 and TNF-α levels were determined in 283 adults with current asthma from the 2nd survey of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA2)...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28339145/respiratory-syncytial-virus-host-interaction-in-the-pathogenesis-of-bronchiolitis-and-its-impact-on-respiratory-morbidity-in-later-life
#12
REVIEW
Giovanni A Rossi, Andrew A Colin
Rossi GA, Colin AA(.) Respiratory syncytial virus - host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life. Pediatr Allergy Immunol. Respiratory syncytial virus (RSV) is the most common agent of severe airway disease in infants and young children. Large epidemiologic studies have demonstrated a clear relationship between RSV infection and subsequent recurrent wheezing and asthma into childhood, thought to be predominantly related to long-term changes in neuroimmune control of airway tone rather than to allergic sensitization...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28338920/dendritic-cell-expression-of-the-signaling-molecule-traf6-is-required-for-immune-tolerance-in-the-lung
#13
Daehee Han, Matthew C Walsh, Kwang Soon Kim, Sung-Wook Hong, Junyoung Lee, Jaeu Yi, Gloriany Rivas, Yongwon Choi, Charles D Surh
Immune tolerance in the lung is important for preventing hypersensitivity, such as allergic asthma. Maintenance of tolerance in the lung is established by coordinated activities of poorly understood cellular and molecular mechanisms, including participation of dendritic cells (DCs). We have previously identified DC expression of the signaling molecule TRAF6 as a non-redundant requirement for the maintenance of immune tolerance in the small intestine of mice. Because mucosal tissues share similarities in how they interact with exogenous antigens, we examined the role of DC-expressed TRAF6 in the lung...
March 11, 2017: International Immunology
https://www.readbyqxmd.com/read/28338907/fish-and-seafood-consumption-during-pregnancy-and-the-risk-of-asthma-and-allergic-rhinitis-in-childhood-a-pooled-analysis-of-18-european-and-us-birth-cohorts
#14
Nikos Stratakis, Theano Roumeliotaki, Emily Oken, Ferran Ballester, Henrique Barros, Mikel Basterrechea, Sylvaine Cordier, Renate de Groot, Herman T den Dekker, Liesbeth Duijts, Merete Eggesbø, Maria Pia Fantini, Francesco Forastiere, Ulrike Gehring, Marij Gielen, Davide Gori, Eva Govarts, Hazel M Inskip, Nina Iszatt, Maria Jansen, Cecily Kelleher, John Mehegan, Carolina Moltó-Puigmartí, Monique Mommers, Andreia Oliveira, Sjurdur F Olsen, Fabienne Pelé, Costanza Pizzi, Daniela Porta, Lorenzo Richiardi, Sheryl L Rifas-Shiman, Sian M Robinson, Greet Schoeters, Marin Strøm, Jordi Sunyer, Carel Thijs, Martine Vrijheid, Tanja G M Vrijkotte, Alet H Wijga, Manolis Kogevinas, Maurice P Zeegers, Leda Chatzi
Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies...
February 27, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28336811/the-circadian-protein-bmal1-in-myeloid-cells-is-a-negative-regulator-of-allergic-asthma
#15
Zbigniew Zaslona, Sarah Case, James O Early, Stephen J Lalor, Rachel M McLoughlin, Anne M Curtis, Luke A O'Neill
Our body clock drives rhythms in the expression of genes that have a 24-hour periodicity. BMAL1 is a transcription factor, which is a crucial component in the molecular clock. A number of physiological processes, including immune function are modulated by the circadian clock. Asthma is of particular relevance to the area of circadian control of immunity, since it is a disease with very strong clinical evidence demonstrating regulation by circadian variation. Airway hypersensitivity and asthma attacks are more common at night in humans...
March 23, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28332366/soluble-cd93-in-serum-as-a-marker-of-allergic-inflammation
#16
Hye Jung Park, Heejae Han, Sang Chul Lee, Young Woong Son, Da Woon Sim, Kyung Hee Park, Yoon Hee Park, Kyoung Yong Jeong, Jung Won Park, Jae Hyun Lee
PURPOSE: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up. RESULTS: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332107/mechanisms-driving-gender-differences-in-asthma
#17
REVIEW
Hubaida Fuseini, Dawn C Newcomb
PURPOSE OF REVIEW: Many phenotypes of asthma exist, ranging from mild asthma with onset during childhood to severe asthma with later onset, making asthma a broad disease with different pathologies. A gender disparity exists in asthma prevalence. As adults, women have an increased asthma prevalence compared to men. Further, women are more likely to have severe asthma and a later onset of asthma compared to men. Here, we review clinical and animal studies that have defined the role of sex hormones in airway inflammation, smooth muscle contraction, mucus production, and airway mechanics associated with asthma pathogenesis...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28329706/exposure-to-bacterial-cpg-dna-protects-from-airway-allergic-inflammation-by-expanding-regulatory-lung-interstitial-macrophages
#18
Catherine Sabatel, Coraline Radermecker, Laurence Fievez, Genevieve Paulissen, Svetoslav Chakarov, Claudia Fernandes, Sabine Olivier, Marie Toussaint, Dimitri Pirottin, Xue Xiao, Pascale Quatresooz, Jean-Claude Sirard, Didier Cataldo, Laurent Gillet, Hicham Bouabe, Christophe J Desmet, Florent Ginhoux, Thomas Marichal, Fabrice Bureau
Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow...
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28328160/co-morbidities-in-severe-asthma-clinical-impact-and-management
#19
REVIEW
Celeste Porsbjerg, Andrew Menzies-Gow
Patients with severe asthma represent a minority of the total asthma population, but carry a majority of the morbidity and healthcare costs. Achieving better asthma control in this group of patients is therefore of key importance. Systematic assessment of patients with possible severe asthma to identify treatment barriers and triggers of asthma symptoms, including co-morbidities, improves asthma control and reduces healthcare costs and is recommended by international guidelines on management of severe asthma...
March 22, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28328094/asthma-management-a-new-phenotype-based-approach-using-presence-of-eosinophilia-and-allergy
#20
REVIEW
Milan Terl, Vratislav Sedlák, Petr Cap, Renata Dvořáková, Viktor Kašák, Tomáš Kočí, Bronislava Novotna, Ester Seberova, Petr Panzner, Vladimir Zindr
Asthma is a heterogeneous disease. The Czech Pneumology and Allergology Societies commissioned 10 experts to review the literature and create joint national guidelines for managing asthma, reflecting this heterogeneity. The aim was to develop an easy-to-use diagnostic strategy as a rational approach to the widening opportunities for the use of phenotype-targeted therapy. The guidelines were presented on websites for public comments by members of both the societies. The reviewers' comments contributed to creating the final version of the guidelines...
March 22, 2017: Allergy
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