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https://www.readbyqxmd.com/read/28214453/reciprocal-regulation-of-enos-h2s-and-co-synthesizing-enzymes-in-human-atheroma-correlation-with-plaque-stability-and-effects-of-simvastatin
#1
Fragiska Sigala, Panagiotis Efentakis, Dimitra Karageorgiadi, Konstadinos Filis, Paraskevas Zampas, Efstathios K Iliodromitis, George Zografos, Andreas Papapetropoulos, Ioanna Andreadou
The molecular and cellular mechanisms underlying plaque destabilization remain obscure. We sought to elucidate the correlation between NO, H2S and CO-generating enzymes, nitro-oxidative stress and plaque stability in carotid arteries. Carotid atherosclerotic plaques were collected from 62 patients who had undergone endarterectomy due to internal artery stenosis. Following histological evaluation the plaques were divided into stable and unstable ones. To investigate the impact of simvastatin we divided patients with stable plaques, into those receiving and to those not receiving simvastatin...
February 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28213038/hydrolysate-from-a-mixture-of-legume-flours-with-antifungal-activity-as-an-ingredient-for-prolonging-the-shelf-life-of-wheat-bread
#2
Carlo Giuseppe Rizzello, Michela Verni, Stefano Bordignon, Valerio Gramaglia, Marco Gobbetti
Aiming at identifying antifungal compounds from plant matrices to be used as ingredients in the bakery industry, a water/salt-soluble extract (WSE) was produced from a legume enzyme hydrolysate, consisting of a mixture of pea, lentil, and faba bean flours, and assayed towards Penicillium roqueforti DPPMAF1. Agar diffusion assays allowed the selection of the optimal processing conditions for hydrolysis. As shown by hyphal radial growth rate, the inhibition was observed towards several fungi, including Aspergillus parasiticus CBS971...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28212299/exogenous-and-endogenous-hydrogen-sulfide-protects-gastric-mucosa-against-the-formation-and-time-dependent-development-of-ischemia-reperfusion-induced-acute-lesions-progressing-into-deeper-ulcerations
#3
Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Zbigniew Sliwowski, Robert Pajdo, Grzegorz Ginter, Slawomir Kwiecien, Tomasz Brzozowski
Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST). The mechanism(s) involved in H₂S-gastroprotection against ischemia/reperfusion (I/R) lesions and their time-dependent progression into deeper gastric ulcerations have been little studied. We determined the effect of l-cysteine, H₂S-releasing NaHS or slow H₂S releasing compound GYY4137 on gastric blood flow (GBF) and gastric lesions induced by 30 min of I followed by 3, 6, 24 and 48 h of R...
February 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211686/multipole-moments-in-the-effective-fragment-potential-method
#4
Colleen Bertoni, Lyudmila V Slipchenko, Alston J Misquitta, Mark S Gordon
In the effective fragment potential (EFP) method the Coulomb potential is represented using a set of multipole moments generated by the distributed multipole analysis (DMA) method. Misquitta, Stone, and Fazeli recently developed a basis space-iterated stockholder atom (BS-ISA) method to generate multipole moments. This study assesses the accuracy of the EFP interaction energies using sets of multipole moments generated from the BS-ISA method, and from several versions of the DMA method (such as analytic and numeric grid-based), with varying basis sets...
February 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28209838/genome-sequence-of-type-strain-fonsecaea-multimorphosa-cbs-980-96-t-a-causal-agent-of-feline-cerebral-phaeohyphomycosis
#5
Aniele C Ribas Leao, Vinicius Almir Weiss, Vania Aparecida Vicente, Flavia Costa, Amanda Bombassaro, Roberto Tadeu Raittz, Maria Berenice R Steffens, Fabio Oliveira Pedrosa, Renata R Gomes, Valter Baura, Helisson Faoro, Michelle Zibetti Tadra Sfeir, Eduardo Balsanelli, Leandro F Moreno, M Javad Najafzadeh, Sybren de Hoog, Emanuel Maltempi Souza
A draft genome sequence of type strain Fonsecaea multimorphosa CBS 980.96(T) was obtained. This species was first isolated from a cat with cerebral phaeohyphomycosis in Queensland, Australia.
February 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28199110/kinetics-of-hydrogen-abstraction-and-addition-reactions-of-3-hexene-by-%C3%A8-h-radicals
#6
Feiyu Yang, Fuquan Deng, Youshun Pan, Yingjia Zhang, Chenglong Tang, Zuohua Huang
Rate coefficients of H-atom abstraction and H-atom addition reactions of 3-hexene by the hydroxyl radicals were determined using both conventional transition-state theory and canonical variational transition-state theory, with potential energy surface (PES) evaluated at the CCSD(T)/CBS//BHandHLYP/6-311G (d, p) level and quantum mechanical effect corrected by the compounded methods including one-dimensional Wigner method, multi-dimensional zero-curvature tunneling method and small-curvature tunneling method...
February 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28195686/diagnosis-of-anaplastic-lymphoma-kinase-rearrangement-in-cytological-samples-through-a-fluorescence-in-situ-hybridization-based-assay-cytological-smears-versus-cell-blocks
#7
Federica Zito Marino, Giulio Rossi, Matteo Brunelli, Maria Gabriella Malzone, Giuseppina Liguori, Giuseppe Bogina, Alessandro Morabito, Gaetano Rocco, Renato Franco, Gerardo Botti
Anaplastic lymphoma kinase (ALK) status analysis of lung cytological specimens should be successfully encouraged in routine practice because biopsy specimens are not always available. To date, the US Food and Drug Administration has approved both fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) as diagnostic tests for identifying ALK-positive patients eligible for treatment with crizotinib. Although ALK IHC is an optimal diagnostic tool, FISH becomes mandatory in equivocal cases. ALK FISH of paraffin-embedded tissue material is still the gold standard, whereas the cytological specimen assay has not yet been completely standardized...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28190595/fractionated-dynamic-headspace-sampling-in-the-analysis-of-matrices-of-vegetable-origin-in-the-food-field
#8
Erica Liberto, Cecilia Cagliero, Chiara Cordero, Patrizia Rubiolo, Carlo Bicchi, Barbara Sgorbini
Recent technological advances in dynamic headspace sampling (D-HS) and the possibility to automate this sampling method have lead to a marked improvement in its the performance, a strong renewal of interest in it, and have extended its fields of application. The introduction of in-parallel and in-series automatic multi-sampling and of new trapping materials, plus the possibility to design an effective sampling process by correctly applying the breakthrough volume theory, have make profiling more representative, and have enhanced selectivity, and flexibility, also offering the possibility of fractionated enrichment in particular for high-volatility compounds...
February 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28188925/impact-of-genetic-polymorphisms-in-key-enzymes-of-homocysteine-metabolism-on-the-pathophysiology-of-sickle-cell-anemia
#9
Danilo Grünig Humberto da Silva, Edis Belini Junior, Lidiane de Souza Torres, Jessika Viviani Okumura, Willian Marcel Barberino, Renan Garcia de Oliveira, Vanessa Urbinatti Teixeira, Clarisse Lopes de Castro Lobo, Eduardo Alves de Almeida, Claudia Regina Bonini-Domingos
This work aimed at studying a possible influence of methylenetetrahydrofolate reductase (MTHFR; c. 677C>T) and cystathionine β-synthase (CBS; 844ins68) polymorphisms on overall oxidative status of sickle cell anemia (SCA) patients and on routine markers, correlating them with hydroxycarbamide (HC) treatment. We evaluated 95 unrelated and diagnosed SCA patients. All patients received a prophylactic treatment with folic acid of 5mg/day, while 41 (43.2%) of them were under hydroxycarbamide (HC) treatment (average dose: 22mg/kg/day)...
February 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28188160/endogenous-hydrogen-sulfide-contributes-to-uterine-quiescence-during-pregnancy
#10
Xingji You, Zixi Chen, Huina Zhao, Chen Xu, Weina Liu, Qianqian Sun, Ping He, Hang Gu, Xin Ni
Recent evidence suggests that uterine activation for labor is associated with inflammation within uterine tissues. Hydrogen sulfide (H2S) plays a critical role in inflammatory responses in various tissues. Our previous study has shown that human myometrium produces H2S via its generating enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthetase (CBS) during pregnancy. We therefore explored whether H2S plays a role in the maintenance of uterine quiescence during pregnancy. Human myometrial biopsies were obtained from pregnant women at term...
February 10, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28185984/hydrogen-sulfide-in-paraventricular-nucleus-attenuates-blood-pressure-by-regulating-oxidative-stress-and-inflammatory-cytokines-in-high-salt-induced-hypertension
#11
Yan-Feng Liang, Dong-Dong Zhang, Xiao-Jing Yu, Hong-Li Gao, Kai-Li Liu, Jie Qi, Hong-Bao Li, Qiu-Yue Yi, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Yu-Ming Kang
Hydrogen sulfide (H2S) is an important gaseous signaling molecule in neuro-modulation, anti-inflammatory, anti-oxidant and anti-hypertensive effects. The paraventricular nucleus (PVN) is a major integrative nucleus in regulating BP and SNA. The aim of this study is to explore whether endogenous or exogenous H2S changed by hydroxylamine hydrochloride (HA) or GYY4137 infused in the PVN affects RSNA and MAP by regulating oxidative stress or the balance between pro-inflammatory cytokines (PICs) and anti-inflammatory cytokines in high salt-induced hypertensive rats...
February 6, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28180086/draft-genome-sequence-of-sugiyamaella-xylanicola-ufmg-cm-y1884-t-a-xylan-degrading-yeast-species-isolated-from-rotting-wood-samples-in-brazil
#12
Thiago M Batista, Rennan G Moreira, Heron O Hilário, Camila G Morais, Glória R Franco, Luiz H Rosa, Carlos A Rosa
We present the draft genome sequence of the type strain of the yeast Sugiyamaella xylanicola UFMG-CM-Y1884(T) (= UFMG-CA-32.1(T) = CBS 12683(T)), a xylan-degrading species capable of fermenting d-xylose to ethanol. The assembled genome has a size of ~ 13.7 Mb and a GC content of 33.8% and contains 5971 protein-coding genes. We identified 15 genes with significant similarity to the d-xylose reductase gene from several other fungal species. The draft genome assembled from whole-genome shotgun sequencing of the yeast Sugiyamaella xylanicola UFMG-CM-Y1884(T) (= UFMG-CA-32...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/28179466/blood-based-nfl-a-biomarker-for-differential-diagnosis-of-parkinsonian-disorder
#13
Oskar Hansson, Shorena Janelidze, Sara Hall, Nadia Magdalinou, Andrew J Lees, Ulf Andreasson, Niklas Norgren, Jan Linder, Lars Forsgren, Radu Constantinescu, Henrik Zetterberg, Kaj Blennow
OBJECTIVE: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. METHODS: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts, comprising healthy controls and patients with PD, progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), as well as an early disease cohort (n = 109) of patients with PD, PSP, MSA, or CBS with disease duration ≤3 years...
February 8, 2017: Neurology
https://www.readbyqxmd.com/read/28177674/exercise-restores-bioavailability-of-hydrogen-sulfide-and-promotes-autophagy-influx-in-livers-of-mice-fed-with-high-fat-diet
#14
Bing Wang, Jing Zeng, Qi Gu
In the gold standard treatment for non-alcoholic fatty liver disease (NAFLD), exercise training has been shown to effectively improve NASH. However, limited data are available about the underlying mechanisms involved. This work was undertaken to investigate the mechanisms underlying the beneficial effect of exercise training on high-fat diet (HFD)-induced NAFLD in mice. Male mice were fed with HFD and given moderate-intensity exercise for 24 weeks. Exercise training lowered weight gain, attenuated systemic insulin resistance and glucose intolerance, mitigated hepatic steatosis and fibrosis in mice fed with HFD...
January 10, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28168314/cocoa-butter-like-lipid-production-ability-of-non-oleaginous-and-oleaginous-yeasts-under-nitrogen-limited-culture-conditions
#15
Yongjun Wei, Verena Siewers, Jens Nielsen
Cocoa butter (CB) extracted from cocoa beans is the main raw material for chocolate production. However, growing chocolate demands and limited CB production has resulted in a shortage of CB supply. CB is mainly composed of three different kinds of triacylglycerols (TAGs), POP (C16:0-C18:1-C16:0), POS (C16:0-C18:1-C18:0), and SOS (C18:0-C18:1-C18:0). The storage lipids of yeasts, mainly TAGs, also contain relative high-level of C16 and C18 fatty acids and might be used as CB-like lipids (CBL). In this study, we cultivated six different yeasts, including one non-oleaginous yeast strain, Saccharomyces cerevisiae CEN...
February 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28165889/force-induced-h2s-by-pdlscs-modifies-osteoclastic-activity-during-tooth-movement
#16
F Liu, F Wen, D He, D Liu, R Yang, X Wang, Y Yan, Y Liu, X Kou, Y Zhou
Hydrogen sulfide (H2S), a gasotransmitter, has been recently linked to mesenchymal stem cell (MSC) function and bone homeostasis. Periodontal ligament stem cells (PDLSCs) are the main MSCs in PDL, which respond to mechanical force to induce physiological activities during orthodontic tooth movement (OTM). However, it is unknown whether mechanical force might induce endogenous H2S production by PDLSCs to regulate alveolar bone homeostasis. Here, we used a mouse OTM model to demonstrate that orthodontic force-induced endogenous H2S production in PDL tissue was associated with macrophage accumulation and osteoclastic activity in alveolar bone...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28161784/benchmark-dft-assessments-cooperativity-and-energy-decomposition-analysis-of-the-hydrogen-bonds-in-hcn-hnc-oligomeric-complexes
#17
Paulo McMiller C de Oliveira, Juliana A B Silva, Ricardo L Longo
Hydrogen cyanide (HCN) and its tautomer hydrogen isocyanide (HNC) are relevant for extraterrestrial chemistry and possible relation to the origin of biomolecules. Several processes and reactions involving these molecules depend on their intermolecular interactions that can lead to aggregates and liquids especially due to the hydrogen bonds. It is thus important to comprehend, to describe, and to quantify their hydrogen bonds, mainly their nature and the cooperativity effects. A systematic study of all linear complexes up to pentamers of HCN and HNC is presented...
February 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28161778/benchmarking-dft-methods-with-small-basis-sets-for-the-calculation-of-halogen-bond-strengths
#18
Antti Siiskonen, Arri Priimagi
In recent years, halogen bonding has become an important design tool in crystal engineering, supramolecular chemistry and biosciences. The fundamentals of halogen bonding have been studied extensively with high-accuracy computational methods. Due to its non-covalency, the use of triple-zeta (or larger) basis sets is often recommended when studying halogen bonding. However, in the large systems often encountered in supramolecular chemistry and biosciences, large basis sets can make the calculations far too slow...
February 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28161170/maternal-supplementation-with-rumen-protected-methionine-increases-prepartal-plasma-methionine-concentration-and-alters-hepatic-mrna-abundance-of-1-carbon-methionine-and-transsulfuration-pathways-in-neonatal-holstein-calves
#19
C B Jacometo, Z Zhou, D Luchini, M N Corrêa, J J Loor
An important mechanism of nutritional "programming" induced by supplementation with methyl donors during pregnancy is the alteration of mRNA abundance in the offspring. We investigated the effects of rumen-protected Met (RPM) on abundance of 17 genes in the 1-carbon, Met, and transsulfuration pathways in calf liver from cows fed the same basal diet without (control, CON) or with RPM at 0.08% of diet dry matter/d (MET) from -21 through +30 d around calving. Biopsies (n = 8 calves per diet) were harvested on d 4, 14, 28, and 50 of age...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28160110/brettanomyces-acidodurans-sp-nov-a-new-acetic-acid-producing-yeast-species-from-olive-oil
#20
Gábor Péter, Dénes Dlauchy, Andrea Tóbiás, László Fülöp, Martina Podgoršek, Neža Čadež
Two yeast strains representing a hitherto undescribed yeast species were isolated from olive oil and spoiled olive oil originating from Spain and Israel, respectively. Both strains are strong acetic acid producers, equipped with considerable tolerance to acetic acid. The cultures are not short-lived. Cellobiose is fermented as well as several other sugars. The sequences of their large subunit (LSU) rRNA gene D1/D2 domain are very divergent from the sequences available in the GenBank. They differ from the closest hit, Brettanomyces naardenensis by about 27%, mainly substitutions...
February 3, 2017: Antonie Van Leeuwenhoek
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