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Parichat Into, Ana Pontes, Noémie Jacques, Serge Casaregola, Savitree Limtong, José Paulo Sampaio
During a survey of the yeast community associated with the phylloplane of corn in Thailand, a basidiomycetous yeast strain belonging to the genus Papiliotrema was isolated. Analyses of the D1/D2 domains of the 26S (LSU) rRNA gene and complete ITS region supported the recognition of a novel species, for which the name Papiliotrema plantarum sp. nov. is proposed (type strain DMKU-CP801T =CBS 15220T =PYCC 7257T ). Another strain of P. plantarum sp. nov., isolated in French Guiana, was found to be sexually compatible with the Thai isolate and mycelium with clamp connections, basidia and basidiospores were observed in culture...
April 20, 2018: International Journal of Systematic and Evolutionary Microbiology
Konstantinos Anastasiadis, Elisabeth A Koulaouzidou, Georgios Palaghias, George Eliades
PURPOSE: To evaluate the effects on the surface properties (morphology, roughness, microhardness, composition) and bond strength to composite of four types of base cements (Equia-Fil/EQF, Angelus white MTA/MTA, Biodentin/ BDN and IRM/IRM) when treated with phosphoric acid etching (PAE) or two self-etch adhesives (Select One Prime & Bond and Clearfil S3 Bond). MATERIALS AND METHODS: Disk-shaped specimens were prepared and stored until complete setting. The surfaces before and after treatments were examined by stereomicroscopy, optical profilometry, ATR-FTIR, and LV-SEM/EDX...
April 19, 2018: Journal of Adhesive Dentistry
Yu Amanda Guo, Mei Mei Chang, Weitai Huang, Wen Fong Ooi, Manjie Xing, Patrick Tan, Anders Jacobsen Skanderup
Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. Here, we unbiasedly analyze 212 gastric cancer (GC) whole genomes to identify recurrently mutated non-coding regions in GC. Applying comprehensive statistical approaches to accurately model background mutational processes, we observe significant enrichment of non-coding indels (insertions/deletions) in three gastric lineage-specific genes. We further identify 34 mutation hotspots, of which 11 overlap CTCF binding sites (CBSs)...
April 18, 2018: Nature Communications
Heejune Park, Giovanni Meloni
In this study, interactions between the superalkali species Li3F2 and four volatile organic compounds (VOCs), methanol, ethanol, formaldehyde, and acetaldehyde, are assessed using the CBS-QB3 composite model. Adiabatic ionization energy (AIE), adiabatic electron affinity (AEA), binding energy (BE), charge transfer (∆q), and highest occupied molecular orbital and lowest unoccupied molecular orbital (HOMO-LUMO) gaps have been computed. Stronger interactions are observed between Li3F2 and the aldehydes than alcohols...
April 18, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Kiersten L Gurley, Shamai A Grossman, Margaret Janes, C Winnie Yu-Moe, Ellen Song, Carrie D Tibbles, Nathan I Shapiro, Carlo L Rosen
BACKGROUND: Data are lacking on how emergency medicine (EM) malpractice cases with resident involvement differs from cases that do not name a resident. OBJECTIVES: To compare malpractice case characteristics in cases where a resident is involved (resident case) to cases that do not involve a resident (non-resident case) and to determine factors that contribute to malpractice cases utilizing EM as a model for malpractice claims across other medical specialties. METHODS: We used data from the Controlled Risk Insurance Company (CRICO) Strategies' division Comparative Benchmarking System (CBS) to analyze open and closed EM cases asserted from 2009-2013...
April 17, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Ning Liu, Xiaoshi Ma, Xuan Luo, Yunchang Zhang, Yu He, Zhaolai Dai, Ying Yang, Guoyao Wu, Zhenlong Wu
Background: Programmed cell death plays a fundamental role in intestinal development and mucosal homeostasis. Dysregulation of these processes is associated with an impaired intestinal-mucosal barrier, reduced nutrient absorption, and initiation and progression of intestinal diseases. 4-Hydroxy-2-nonenal (4-HNE), a product of lipid peroxidation, is commonly used to induce oxidative stress in cells. l-Glutamine is known to protect cells from apoptosis. However, the underlying mechanisms are largely unknown...
April 1, 2018: Journal of Nutrition
Christopher J Smith, Anna K Huff, Rebecca B Mackenzie, Kenneth R Leopold
The complex formed from acetic sulfuric anhydride (CH3 COOSO2 OH, ASA) and water has been observed by pulsed nozzle Fourier transform microwave spectroscopy. ASA was formed in situ in the supersonic jet via the reaction of SO3 and CH3 COOH, and subsequently complexed with water using a concentric, dual injection needle that allows reagents to be introduced at different points along the expansion axis. Spectroscopic constants for the parent, fully deuterated, and CH3 13 COOSO2 OH species are reported. Both A and E internal rotor states have been observed and analyzed...
April 16, 2018: Journal of Physical Chemistry. A
Ying Ma, Zhonghai Yan, Xiaomei Deng, Junqi Guo, Jinxia Hu, Yuan Yu, Fei Jiao
Despite huge advances in lung cancer treatment, resistance to cisplatin‑based chemotherapy remains one of the major obstacles, and the elucidation of cisplatin resistance remains challenging. As an important biological and pharmacological mediator, hydrogen sulfide (H2S) performs a variety of homeostatic functions related to cancer formation and development. However, the effects of H2S on cisplatin‑resistance lung cancer remain largely unknown. In the present study, we investigated the anticancer effects and relevant mechanisms of NaHS (an exogenous donor of H2S) on A549/DDP cells (cisplatin‑resistant)...
April 12, 2018: Oncology Reports
Alexandra Kotogán, Carolina Zambrano, Anita Kecskeméti, Mónika Varga, András Szekeres, Tamás Papp, Csaba Vágvölgyi, Miklós Takó
Lipase enzymes of the oleaginous fungal group Mortierella are rarely studied. However, considering that most commercial lipases are derived from filamentous fungal sources, their investigation can contribute to the cost-effective development of new biotechnological processes. Here, an extracellular lipase with a molecular mass of 30 kDa was isolated from Mortierella echinosphaera CBS 575.75 and characterized. The purified lipase exhibited an optimal p -nitrophenyl palmitate ( p NPP)-hydrolyzing activity at 25 °C and pH 6...
April 10, 2018: International Journal of Molecular Sciences
Srinivas Monangi, Rangraj Setlur, Ramprasad Ramanathan, Sidharth Bhasin, Mridul Dhar
Background: "Code blue" (CB) is a popular hospital emergency code, which is used by hospitals to alert their emergency response team of any cardiorespiratory arrest. The factors affecting the outcomes of emergencies are related to both the patient and the nature of the event. The primary objective was to analyze the survival rate and factors associated with survival and also practical problems related to functioning of a CB system (CBS). Materials and Methods: After the approval of hospital ethics committee, an analysis and audit was conducted of all patients on whom a CB had been called in our tertiary care hospital over 24 months...
April 2018: Saudi Journal of Anaesthesia
Zachary Wilseck, Luis Savastano, Neeraj Chaudhary, Aditya S Pandey, Julius Griauzde, Sumanna Sankaran, David Wilkinson, Joseph J Gemmete
Carotid blowout syndrome (CBS) is a known devastating complication of head and neck surgery. The risk of developing CBS increases in the setting of radiation therapy, wound breakdown, or tumor recurrence. Traditionally, the treatment of choice for CBS is surgical ligation of the bleeding artery; however, recently, endovascular occlusion has become a more common option. If a pseudoaneurysm is present, treatment consists of trapping with endovascular coils or occlusion with a liquid embolic agent. Delayed migration of embolization coils into the airway causing acute respiratory distress is a rare occurrence...
April 7, 2018: Journal of Neurointerventional Surgery
Di Lu, Jianyong Zhuo, Modan Yang, Chao Wang, Pan Linhui, Haiyang Xie, Xiao Xu, Shusen Zheng
BACKGROUNDS AND AIM: Hepatitis B recurrence adversely affects patients' survival after liver transplantation. This study aims to find association between donor gene variations of one carbon metabolism and post-transplant hepatitis B recurrence. METHODS: This study enrolled 196 patients undergoing liver transplantation for HBV related end-stage liver diseases. We detected 11 single nucleotide polymorphisms (SNP) of 7 one-carbon metabolism pathway genes (including MTHFR, MTR, MTRR, ALDH1L1, GART, SHMT1 and CBS) in donor livers and analyzed their association with HBV reinfection after liver transplantation...
April 5, 2018: Gene
Jing Huang, Cui-Ying Li, Jiu-Hui Jiang
BACKGROUND: This systematic review and meta-analysis aimed to identify whether there is any relationship between fixed orthodontic appliances and malodor, and if self-ligating brackets (SLBs) prevent malodor better than conventional brackets (CBs). METHODS: The electronic databases PubMed, Ovid, EMBASE, and the Cochrane Library were searched from inception to September 2016; a manual search was also performed. Randomized controlled and clinical controlled trials, in which experimental groups received fixed orthodontic therapy and malodor was measured, were included...
April 2018: Medicine (Baltimore)
Erik Engwall, Lars Glimelius, Elin Hynning
 small cell lung cancer (NSCLC) is a tumour type thought to be well-suited for
 proton radiotherapy. However, the lung region poses many problems related to organ
 motion and can for actively scanned beams induce severe interplay effects. In this study we investigate four mitigating rescanning techniques: (1) volumetric rescanning, (2) layered rescanning, (3) breath-sampled (BS) layered rescanning, and (4) continuous breath-sampled (CBS) layered rescanning. The breath-sampled methods will spread the layer rescans over a full breathing cycle, resulting in an improved averaging effect at the expense of longer treatment times...
April 4, 2018: Physics in Medicine and Biology
Erin M Leonard, Shaima Salman, Colin A Nurse
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood. In mammals, the bilaterally-paired carotid bodies (CBs) are the main peripheral chemoreceptor organs that are richly vascularized and are strategically located at the carotid bifurcation. The CBs contribute to the maintenance of O2 , CO2 /H+ , and glucose homeostasis and have attracted much clinical interest because hyperactivity in these organs is associated with several pathophysiological conditions including sleep apnea, obstructive lung disease, heart failure, hypertension, and diabetes...
2018: Frontiers in Physiology
Rosario Isasi, Cherie Mastronardi, Mia Golder, David Allan, Mark Walker, Mike Halpenny, Lin Yang, Heidi Elmoazzen, Sophie Chargé
BACKGROUND: Research is needed to enhance cord blood (CB) transplantation outcomes and to develop new clinical applications. Based on quality criteria for transplantation, CB collected by public CB banks (CBBs) is often unsuitable for banking, but may still be valuable for research. Canadian researchers have described a need for a centralized program providing ethically sourced CB for research projects. To meet this need, Canadian Blood Services (CBS), in partnership with The Ottawa Hospital, launched the Cord Blood for Research Program (CBRP) in 2014...
April 1, 2018: Transfusion
Y F Ma, Z H Wu, M Gao, J J Loor
Nuclear factor (erythroid-derived 2)-like factor 2 (NFE2L2, formerly Nrf2) is a transcription factor that binds to the antioxidant response element (ARE) in the upstream promoter region of various antioxidant-responsive genes. Hence, at least in nonruminants, the NFE2L2-ARE signaling pathway plays an important role in the cellular antioxidant defense system. Whether oxidative stress in bovine mammary epithelial cells alters NFE2L2 or the NFE2L2-ARE pathway is unclear. Therefore, the objective of this study was to examine the response in NFE2L2- and NFE2L2-ARE-related components in bovine mammary epithelial cells (BMEC) under oxidative stress...
March 28, 2018: Journal of Dairy Science
Aslı Ünal, Uğur Bozkaya
An extensive study of structures and energetics for anionic pentamer and hexamer clusters is performed employing high level ab initio quantum chemical methods, such as the density-fitted orbital-optimized linearized coupled-cluster doubles (DF-OLCCD), coupled-cluster singles and doubles (CCSD), and coupled-cluster singles and doubles with perturbative triples [CCSD(T)] methods. In this study, sixteen anionic pentamer clusters and eighteen anionic hexamer clusters are reported. Relative, binding, and vertical detachment energies (VDE) are presented at the complete basis set limit (CBS), extrapolating energies of aug4-cc-pVTZ and aug4-cc-pVQZ custom basis sets...
March 28, 2018: Journal of Chemical Physics
Jian-du Yang, Qi Sun, Xiao-Gang Guo, Gong-Bu Zhou, Xu Liu, Bin Luo, Hui-Qiang Wei, Jackson J Liang, Jian Ma
INTRODUCTION: The 'Crosstalk' technique- if pulmonary vein isolation (PVI) of the superior one is not achieved due to a gap in the inferior part, it could be done during inferior vein cryo-ablation. This maneuver while minimizing the total energy delivery time and number of lesions. We aimed to correlate the likelihood of crosstalk phenomenon with certain anatomic characteristics. METHODS: A total of 676 patients undergoing a first ablation procedure for paroxysmal or persistent AF (470 first-generation cryoballoon (CB) and 206 second-generation CB) between June 2014 and December 2016 were included...
March 30, 2018: Pacing and Clinical Electrophysiology: PACE
Shinae Kim, Chelsea M Kaliszewski, Emilie B Guidez, Mark S Gordon
The usual modeling of dispersion interactions in density functional theory (DFT) is often limited by the use of empirically fitted parameters. In this study, the accuracies of the popular empirical dispersion corrections and the first principles derived effective fragment potential (EFP) dispersion correction are compared by computing the DFT-D and HF-D equilibrium interaction energies and intermolecular distances of the S22 test set dimers. Functionals based on the local density approximation (LDA) and generalized gradient approximation (GGA) as well as hybrid functionals are compared for the DFT-D calculations, using coupled cluster CCSD(T) at the complete basis set (CBS) limit as the reference method...
March 30, 2018: Journal of Physical Chemistry. A
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