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https://www.readbyqxmd.com/read/28550262/increased-plasma-homocysteine-level-is%C3%A2-associated-with-executive-dysfunction-in%C3%A2-type-2-diabetic-patients-with-mild-cognitive-impairment
#1
Sai Tian, Jing Han, Rong Huang, Jie Sun, Rongrong Cai, Yanjue Shen, Shaohua Wang
BACKGROUND: Homocysteine (Hcy) is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. OBJECTIVE: We aimed to investigate the role of Hcy in T2DM patients with mild cognitive impairment (MCI), and to determine whether methylene tetrahydrofolate reductase (MTHFR) C677T or cystathionine beta-synthase (CBS) 844ins68 polymorphism is related to T2DM-associated MCI. METHODS: We recruited 285 T2DM patients and divided them into two groups, 140 patients with MCI, and 145 healthy-cognition controls, on the basis of Montreal Cognitive Assessment (MoCA) scores...
May 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28548852/unification-of-the-w1x-and-g4-mp2-6x-composite-protocols
#2
Bun Chan
We have devised the composite procedures WG and WGh to unify the W1X and the (computationally more economical) G4(MP2)-6X protocols. The WG procedure employs a combination of MP2, MP2-F12, CCSD-F12b, and CCSD(T) to approximate the all-electron scalar-relativistic CCSD(T)/CBS energy. In addition, it incorporates features such as the scaling of the energy components and an empirical "higher-level-correction" term. The WGh protocol represents a somewhat more economical variant of WG with partial removal of diffuse functions...
May 26, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28546478/draft-genome-sequence-of-the-mycoparasitic-oomycete-pythium-oligandrum-strain-cbs-530-74
#3
Sandeep K Kushwaha, Ramesh R Vetukuri, Laura J Grenville-Briggs
The oomycete Pythium oligandrum is a mycoparasite and licenced biological control agent. Here, we report the draft genome sequence of P. oligandrum strain CBS 530.74, which is 36.80 Mb. It contains 341 scaffolds and 11,647 predicted protein-coding genes. As reported for plant-pathogenic Pythium species, RXLR-type effector sequences are absent.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28545163/coccygeal-body-revisited-an-immunohistochemical-study-using-donated-elderly-cadavers
#4
Zhe Wu Jin, Kwang Ho Cho, Hyung Suk Jang, Gen Murakami, Jose Francisco Rodríguez-Vázquez, Masahito Yamamoto, Shin-Ichi Abe
To describe the normal anatomy and histology of the adult coccygeal body (CB) and to discuss about the origin and function. Using immunohistochemistry, we examined 29 CBs found in 32 elderly donated cadavers without macroscopic pathology in the pelvis. The CB was usually located in or near the anococcygeal ligaments. It was almost always composed of multiple masses or nodules of round glomus cells (smooth muscle actin, or SMA++). However, the CB sometimes contained abundant dilated veins with scattered glomus cells...
May 25, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28537489/hydrogen-sulfide-as-a-potential-target-in-preventing-spermatogenic-failure-and-testicular-dysfunction
#5
Jing Wang, Wan Wang, Shuangyue Li, Yi Han, Ping Zhang, Guoliang Meng, Yujiao Xiao, Liping Xie, Xin Wang, Jiahao Sha, Qi Chen, Philip K Moore, Rui Wang, Wenpei Xiang, Yong Ji
AIMS: Testis and sperm are particularly susceptible to inflammation and oxidative stress. Although Hydrogen sulfide (H2S) has been considered as an important biological signaling molecule in inflammatory and oxidative stress processes, its role in male reproductive system was poorly understood. The aim of this study was to investigate the role of H2S in the regulation of male reproductive system. RESULTS: We found that both sub-fertile and infertile patients, especially asthenospermic patients, exhibited a decreased concentration of H2S in their seminal plasma and diminished expression of H2S-generating enzyme (cystathionine β-synthase, CBS) in sperm...
May 24, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28537281/comprehensive-theoretical-study-of-all-1812-c60-isomers
#6
Rebecca Sure, Andreas Hansen, Peter Schwerdtfeger, Stefan Grimme
We investigate all 1812 isomers of the fullerene C60 consistently with high-accuracy quantum chemistry methods. The isomers are optimized at the PBE-D3/def2-TZVP level of theory and their relative energies are obtained at the affordable and accurate hybrid-DFT level PW6B95-D3(ATM)/def2-QZVP. For the first time reliable values for the relative energy distribution among the 1812 isomers (maximum value of 549.1 kcal mol(-1), average value of 189.8 ± 46.8 kcal mol(-1), 1267 isomers in an energy window of 150-250 kcal mol(-1)) are given...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28536766/pediatric-radiology-malpractice-claims-characteristics-and-comparison-to-adult-radiology-claims
#7
REVIEW
Micheál A Breen, Kathy Dwyer, Winnie Yu-Moe, George A Taylor
Medical malpractice is the primary method by which people who believe they have suffered an injury in the course of medical care seek compensation in the United States and Canada. An increasing body of research demonstrates that failure to correctly diagnose is the most common allegation made in malpractice claims against radiologists. Since the 1994 survey by the Society of Chairmen of Radiology in Children's Hospitals (SCORCH), no other published studies have specifically examined the frequency or clinical context of malpractice claims against pediatric radiologists or arising from pediatric imaging interpretation...
June 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28531158/impact-analysis-of-flow-shaping-in-ethernet-avb-tsn-and-afdx-from-network-calculus-and-simulation-perspective
#8
Feng He, Lin Zhao, Ershuai Li
Ethernet-AVB/TSN (Audio Video Bridging/Time-Sensitive Networking) and AFDX (Avionics Full DupleX switched Ethernet) are switched Ethernet technologies, which are both candidates for real-time communication in the context of transportation systems. AFDX implements a fixed priority scheduling strategy with two priority levels. Ethernet-AVB/TSN supports a similar fixed priority scheduling with an additional Credit-Based Shaper (CBS) mechanism. Besides, TSN can support time-triggered scheduling strategy. One direct effect of CBS mechanism is to increase the delay of its flows while decreasing the delay of other priority ones...
May 22, 2017: Sensors
https://www.readbyqxmd.com/read/28529880/cytologic-assessment-of-estrogen-receptor-progesterone-receptor-and-her2-status-in-metastatic-breast-carcinoma
#9
Fresia Pareja, Melissa P Murray, Ryan Des Jean, Fumiko Konno, Maria Friedlander, Oscar Lin, Marcia Edelweiss
BACKGROUND: Discordance in the receptor status between primary breast carcinomas (PBC) and corresponding metastasis is well documented. Interrogation of the receptor status of metastatic breast carcinoma (MBC) in cytology material is common practice; however, its utility has not been thoroughly validated. We studied patients with MBC, and evaluated the concordance rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between PBC surgical specimens and corresponding MBC cell blocks (CBs)...
January 2017: Journal of the American Society of Cytopathology
https://www.readbyqxmd.com/read/28527463/sub-doppler-infrared-spectroscopy-of-ch2oh-radical-in-a-slit-supersonic-jet-vibration-rotation-tunneling-dynamics-in-the-symmetric-ch-stretch-manifold
#10
Michael D Schuder, Fang Wang, Chih-Hsuan Chang, David J Nesbitt
The sub-Doppler CH-symmetric stretch (ν3) infrared absorption spectrum of a hydroxymethyl (CH2OH) radical is observed and analyzed with the radical formed in a slit-jet supersonic discharge expansion (Trot = 18 K) via Cl atom mediated H atom abstraction from methanol. The high sensitivity of the spectrometer and reduced spectral congestion associated with the cooled expansion enable first infrared spectroscopic observation of hydroxymethyl transitions from both ± symmetry tunneling states resulting from large amplitude COH torsional motion...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28523891/neonatal-endocrinologic-problems-in-collodion-babies
#11
Ahmet Ozdemir, Sabriye Korkut, Selim Kurtoglu, Nihal Hatipoglu, Tamer Gunes, Mehmet Adnan Ozturk
OBJECTIVES: To identify endocrinologic problems, particularly those concerning growth, in collodion babies (CBs). METHODS: Clinically identified newborn CBs were included in the study group (group 1). Because CBs are generally born premature, small for gestational age (SGA), or both, a control group matched to the study group in terms of gestational age and birthweight (group 2) was also established. Blood specimens were collected from both groups for thyroid function tests and to measure serum growth hormone (GH), insulinlike growth factor 1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28514598/the-communal-relation-of-mthfr-mtr-ace-gene-polymorphisms-and-hyperhomocysteinemia-as-conceivable-risk-of-coronary-artery-disease
#12
Rizwan Masud, Haider Zaigham Baqai
Homocysteine and its modulating genes have strongly emerged as novel biomarkers for coronary artery disease (CAD). In present study, we investigated whether polymorphisms in homocysteine pathway genes and the plasma levels of homocysteine, folate and vitamin B12, independently or in combination, are associated with CAD risk. A total of 504 participants were recruited (cases n = 254, controls n = 250, respectively). Tetra primer allele refractory mutation system (ARMS) PCR was used for resolving the genotypes of 5'10' methylenetetrahydrofolate reductase 'MTHFR' polymorphisms (rs1801133, rs1801131), 5' methyl tetrahydrofolate homocysteine methyltransferase 'MTR' polymorphism (rs1805087), paroxanse1 'PON1' polymorphism (rs662), and cystathionine beta synthase 'CBS' polymorphism (rs5742905)...
May 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28512525/h2s-donor-nahs-changes-the-production-of-endogenous-h2s-and-no-in-d-galactose-induced-accelerated-ageing
#13
Wei Wu, Cui-Lan Hou, Xue-Pan Mu, Chen Sun, Yi-Chun Zhu, Ming-Jie Wang, Qian-Zhou Lv
Aims. The study was designed to explore whether hydrogen sulphide (H2S) and nitric oxide (NO) generation changed in D-galactose- (D-gal-) induced ageing, the possible effects of exogenous H2S supplementation, and related mechanisms. Results. In D-gal-induced senescent mice, both H2S and NO levels in the heart, liver, and kidney tissues were decreased significantly. A similar trend was observed in D-gal-challenged human umbilical vein endothelial cells (HUVECs). Sustained H2S donor (NaHS) treatment for 2 months elevated H2S and NO levels in these mice, and during this period, the D-gal-induced senescent phenotype was reversed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28512446/neuroprotective-roles-of-l-cysteine-in-attenuating-early-brain-injury-and-improving-synaptic-density-via-the-cbs-h2s-pathway-following-subarachnoid-hemorrhage-in-rats
#14
Tong Li, Lingxiao Wang, Quan Hu, Song Liu, Xuemei Bai, Yunkai Xie, Tiantian Zhang, Shishi Bo, Xiangqian Gao, Shuhua Wu, Gang Li, Zhen Wang
l-Cysteine is a semi-essential amino acid and substrate for cystathionine-β-synthase (CBS) in the central nervous system. We previously reported that NaHS, an H2S donor, significantly alleviated brain damage after subarachnoid hemorrhage (SAH) in rats. However, the potential therapeutic value of l-cysteine and the molecular mechanism supporting these beneficial effects have not been determined. This study was designed to investigate whether l-cysteine could attenuate early brain injury following SAH and improve synaptic function by releasing endogenous H2S...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28507667/photoacoustic-probes-for-real-time-tracking-of-endogenous-h2s-in-living-mice
#15
Ben Shi, Xianfeng Gu, Qiang Fei, Chunchang Zhao
H2S is a key chemical mediator that exerts a vital role in diverse physiological and pathological processes. However, in vivo tracking of endogenous H2S generation still remains difficult due to the lack of reliable analytical methods. Herein, we present the first example of activatable photoacoustic probes for real-time imaging of H2S in living mice through the full utilization of the superiority of photoacoustic imaging modality at fine spatial resolution during deep tissue penetration. The designed probe can generate high NIR absorption at 780 nm in the presence of H2S, thus producing a strong photoacoustic signal output in the NIR region...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28502790/crystallographic-and-biochemical-characterization-of-the-dimeric-architecture-of-site-2-protease
#16
Magdalena Schacherl, Monika Gompert, Els Pardon, Tobias Lamkemeyer, Jan Steyaert, Ulrich Baumann
Regulated intramembrane proteolysis by members of the site-2 protease family (S2P) is an essential signal transduction mechanism conserved from bacteria to humans. There is some evidence that extra-membranous domains, like PDZ and CBS domains, regulate the proteolytic activity of S2Ps and that some members act as dimers. Here we report the crystal structure of the regulatory CBS domain pair of S2P from Archaeoglobus fulgidus, AfS2P, in the apo and nucleotide-bound form in complex with a specific Nanobody from llama...
May 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28502220/dynamic-assessment-of-visual-neglect-the-mobility-assessment-course-as-a-diagnostic-tool
#17
Antonia F Ten Brink, Johanna M A Visser-Meily, Tanja C W Nijboer
INTRODUCTION: Visual neglect is a frequent disorder following stroke and is often diagnosed by neuropsychological assessment. However, paper-and-pencil tasks have low predictive value as they lack sensitivity to capture neglect in complex, dynamic situations, such as activities of daily living. Aims of the current study were to assess the feasibility of the Mobility Assessment Course (MAC), a visual search multitask, to assess neglect, and its relation with existing neglect tasks. METHOD: Stroke patients admitted for inpatient rehabilitation and healthy controls were tested with the MAC in different corridors...
May 14, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28501605/the-role-of-multilayers-in-preventing-the-premature-buckling-of-the-pulmonary-surfactant
#18
Mustafa Al-Saiedy, Ali Tarokh, Sultan Nelson, Kiavash Hossini, Francis Green, Chang-Chun Ling, Elmar J Prenner, Matthias Amrein
The pulmonary surfactant is a protein-lipid mixture that spreads into a film at the air-lung interface. The highly-compacted molecules of the film keep the interface from shrinking under the influence of otherwise high surface tension and thus prevent atelectasis. We have previously shown that for the film to withstand a high film pressure without collapsing it needs to assume a specific architecture of a molecular monolayer with islands of stacks of molecular multilayers scattered over the area. Surface activity was assessed in a captive bubble surfactometer (CBS) and the role of cholesterol and oxidation on surfactant function examined...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28493867/transplantation-of-purified-ipsc-derived-cardiomyocytes-in-myocardial-infarction
#19
Sebastian V Rojas, George Kensah, Alexander Rotaermel, Hassina Baraki, Ingo Kutschka, Robert Zweigerdt, Ulrich Martin, Axel Haverich, Ina Gruh, Andreas Martens
BACKGROUND: Induced pluripotent stem cells (iPSC) can be differentiated into cardiomyocytes and represent a possible autologous cell source for myocardial repair. We analyzed the engraftment and functional effects of murine iPSC-derived cardiomyocytes (iPSC-CMs) in a murine model of myocardial infarction. METHODS AND RESULTS: To maximize cardiomyocyte yield and purity a genetic purification protocol was applied. Murine iPSCs were genetically modified to express a Zeocin™ resistance gene under control of the cardiac-specific α-myosin heavy chain (α-MHC, MYH6) promoter...
2017: PloS One
https://www.readbyqxmd.com/read/28492150/selective-screening-for-organic-acidurias-and-amino-acidopathies-in-pakistani-children
#20
Noreen Abbas Sherazi, Aysha Habib Khan, Lena Jafri, Azeema Jamil, Nasir Ali Khan, Bushra Afroze
OBJECTIVE: To determine the frequency of organic acidurais (OA) and amino acidopathies (AA) in selected high-risk patients screened in two years. STUDY DESIGN: Retrospective Observational study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital (AKUH), Karachi, from January 2013 to December 2014. METHODOLOGY: Patients with OA and AA were included in the study and patients with IMDs other than OA and AA were excluded...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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