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R M Santi, M Ceccarelli, G Catania, C Monagheddu, A Evangelista, E Bernocco, F Monaco, M Federico, U Vitolo, S Cortelazzo, M G Cabras, M Spina, L Baldini, C Boccomini, A Chiappella, A Bari, S Luminari, M Calabrese, A Levis, C Visco, L Contino, G Ciccone, M Ladetto
BACKGROUND: Recent studies show that the risk of VTE in NHL pts is similar to that observed in high risk solid tumors (i.e. pancreatic, ovarian cancer). VTE in NHL occurs in most cases within three months from diagnosis and can have substantial impact on treatment delivery and outcome as well as on quality of life. However few data are available on potential predictors. AIMS: To better clarify the epidemiology of early (within six months from treatment start) VTE in NHL we conducted a pooled data analysis of 12 clinical trials from FIL...
April 2016: Thrombosis Research
Mayumi Yoshimi, Yutaka Kadowaki, Yuji Kikuchi, Tsuyoshi Takahashi
A 76-year-old woman was referred to our hospital because of anemia. The laboratory findings revealed hemolysis. Although a direct Coombs test was negative, a high titer of RBC-bound IgG was detected, and a diagnosis of Coombs-negative autoimmune hemolytic anemia was made. She was successfully treated with prednisolone. One year and five months later, she again presented anemia and was diagnosed with pure red cell aplasia. Anti-erythropoietin receptor antibody was detected in the serum. She was treated with cyclosporine and obtained prompt recovery...
2016: Internal Medicine
Zuzana Stránská, Štěpán Svačina
Physical inactivity is demonstrably related to the manifestation of chronic diseases which significantly modify the quality and prognosis of life in a negative way. The benefits of exercise are surely mediated by many pathophysiological mechanisms interrelated in varying degrees, which have not yet been fully examined in their complexity. In the late 20th century it was positively proven that a working striated muscle really regulates the metabolic and physiological response in the other organs. These involve several hundred substances with autocrine, paracrine and endocrine effects...
April 2015: Vnitr̆ní Lékar̆ství
Magdalena Maria Fraczek, Katarzyna Łacka
It is well established that thyroid hormones affect the cardiovascular system through genomic and nongenomic actions. TRalpha1 is the major thyroid hormone receptor in the heart. T3 suppresses increased mitotic activity of stimulated cardiomyocytes. Hyperthyroidism induces a hyperdynamic cardiovascular state, which is associated with enhanced left ventricular systolic and diastolic function and the chronotropic and inotropic properties of thyroid hormones. Hypothyroidism, however, is characterized by opposite changes...
September 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Morteza Entezari, Manuchehr Esmaeili, Mehdi Yaseri
BACKGROUND: To evaluate the efficacy of intravenous erythropoietin (EPO) on improvement of visual function and color vision in patients with recent indirect traumatic optic neuropathy (TON). METHODS: In a case series, 18 eyes of 18 patients with diagnosis of indirect TON with duration of less than 2 weeks underwent 20,000 IU intravenous EPO injections daily for 3 days. Best corrected visual acuity (BCVA) and color vision were checked by Ishihara test before, 1, and 3 months after injections...
August 2014: Graefe's Archive for Clinical and Experimental Ophthalmology
Max Hardeman, Tamas Alexy, Bram Brouwer, Philippe Connes, Friedrich Jung, Harm Kuipers, Oguz K Baskurt
Recombinant human erythropoietin (rHuEPO) is an agent commonly used by athletes with the aim to improve performance in endurance sports. However, the scientific community continues to debate the risks, benefits and its mechanism of action when used as a doping agent. This paper provides a brief overview on the pros and cons of rHuEPO use, as discussed by a group of scientist with diverse background, at the 17th Conference of the European Society for Clinical Hemorheology and Microcirculation in Pecs, Hungary...
2014: Biorheology
M Hasanova, Ch Asadov, Z Alimirzoyeva, T Mammadova, A Shirinova
Alpha-thalassemia is widely spread in human population and one of the most common types of α-thalassemia is hemoglobinopathy H which develops with mild microcytic hypochromic anemia, hepatosplenomegaly and jaundice. The basic method of anemia correction is blood transfusion. However this method has crucial deficiencies. As it is known recombinant erythropoetin (rEPO) contributes to erythroid proliferation and could be used for anemia treatment. The aim of the study was to qualify efficiency of administration rEPO in complex therapy of hemaglobinopathy H...
January 2014: Georgian Medical News
Christoph R Werner, Daniel P Egetemeyr, Ulrich M Lauer, Silvio Nadalin, Alfred Königsrainer, Nisar P Malek, Christoph P Berg
Management of recurrent Hepatitis C virus (HCV) infection following liver transplantation remains a major challenge. In non-transplanted HCV genotype 1 patients, the introduction of protease inhibitor-based regimens has significantly increased the rate of sustained virological response. In this follow-up study, on the first published cohort of post-liver transplant patients treated with telaprevir-based triple therapy, we investigated both efficacy and safety data in follow-up to 24 weeks (SVR 24) after end of treatment (EOT)...
2013: PloS One
F Tahan, H H Akar, I Dursun, K Yilmaz
Human recombinant erythropoietins (EPO) and darbepoetins are widely used for anemias associated with chronic kidney disease.  Allergic reactions to erythropoetins and darbepoetins have only occasionally been reported. These skin reactions include pruritus, wheals at the injection site, orofacial anaphylaxis and anjioedema. In this article, we report an 11 year-old female who experienced generalized   erithematous skin eruption and desquamation after both erythropoietin and darbepoetin treatments.  We successfully used darbepoetin with the support of premedication and desensitization...
October 2013: European Annals of Allergy and Clinical Immunology
Margarita Borovka, Sergio Teruya, Julissa Alvarez, Stephen Helmke, Mathew S Maurer
BACKGROUND: Hyporesponders to erythropoietin-stimulating agents (ESAs) have been associated with an increased subsequent risk of death or cardiovascular events. We hypothesized that subjects who are hyporesponsive to erythropoietin alfa would have higher plasma volumes and lower red cell deficits than subjects who are responsive to therapy. METHODS: As part of a prospective, single blind, randomized, placebo-controlled study comparing erythropoietin alfa with placebo in older adults (n = 56) with heart failure and a preserved ejection fraction (HFPEF), we performed blood volume analysis with the use of an indicator dilution technique with (131)iodine-labeled albumin...
October 2013: Journal of Cardiac Failure
Frank Schwarz, Gordon John, Thomas Kaiser, Ilja Mihatovic, Vladimir Golubovic, Jürgen Becker
AIM: The aim of the present study was to investigate the impact of proangiogenic factors [erythropoetin (EPO), human growth hormone (HGH), fibroblast growth factor (FGF), and platelet derived growth factor (PDGF-BB)] on the organization and biodegradation of a porcine-derived collagen matrix (CM) in rats. MATERIAL AND METHODS: Collagen matrix specimens were soak-loaded either with EPO, HGH, FGF or PDGF-BB, each delivered in three concentrations (high, medium, low), and randomly allocated in unconnected subcutaneous pouches separated surgically on the back of 112 Wistar rats, which were divided into four groups (4, 7, 14 and 60 days of healing)...
April 2014: Clinical Oral Implants Research
Marija Jelić, Tatjana Cvetković, Vidojko Djordjević, Goran Damnjanovć, Predrag Vlahović, Gordana Kocić, Natasa Djindjić, Biljana Jovović, Ana Antić
BACKGROUND/AIM: [corrected] Hepcidin may play a pathogenetic role in iron metobolism disorders. The aim of this study was to determine the correlation between hepcidin concentration and parameters of iron metabolism in patients with different stage of chronic kidney disease (CKD). METHODS: The study involved 104 patients with CKD: 64 on hemodialysis (HD) and 40 patients in pre-dialysis stadium (pre-HD) with adequate erythropoetin therapy and iron supplementation...
April 2013: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Iu S Milovanov, L Iu Milovanova
AIM: Comparison of efficacy of 12-month treatment of anemia in patients with chronic kidney disease (CKD) of stage III - IV with a long-acting drug darbepoetin alpha - aranesp and short-acting drug erythropoietin beta - recormon. MATERIAL AND METHODS: A total of 44 patients with CKD of stage III-IVwere divided into two groups. Of them, 24 had chronic glomerulonephritis and 20 had tubulointerstitial nephritis with verified nephrogenic anemia. Group 1 consisted of 22 patients given long-acting erythropoetin (darbepoetin alpha) in an initial dose 0,75 mcg/kg each 2 weeks subcutaneously...
2012: Terapevticheskiĭ Arkhiv
Lin-Xi Li, Shaikh M Atif, Shirdi E Schmiel, Seung-Joo Lee, Stephen J McSorley
Recent studies have shed light on the connection between elevated erythropoetin production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this article, we provide another mouse model, the SIRPα-deficient (Sirpα⁻/⁻) mouse, that manifests increased erythropoiesis as well as heightened susceptibility to Salmonella infection. Sirpα⁻/⁻ mice succumbed to systemic infection with attenuated Salmonella, possessing significantly higher bacterial loads in both the spleen and the liver...
September 1, 2012: Journal of Immunology: Official Journal of the American Association of Immunologists
Laura E A Harrison, James O Burton, Cheuk-Chun Szeto, Philip K T Li, Christopher W McIntyre
BACKGROUND/OBJECTIVES: Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and appears to be driven by acute repetitive dialysis induced circulatory stress. Resistance to erythropoietin (EPO) has been identified as a predictor of mortality risk, and associated with inflammation and malnutrition. This study aims to explore the potential link between previously unrecognised endotoxaemia and EPO Resistance Index (ERI) in HD patients...
2012: PloS One
T Wobrock, A Hasan, P Falkai
Schizophrenia is a brain disorder associated with subtle, but replicable cerebral volume loss mostly prevalent in frontal and temporal brain regions. Post-mortem studies of the hippocampus point to a reduction of the neuropil constituting mainly of synapses associated with changes of molecules mediating plastic responses of neurons during development and learning. Derived from animal studies interventions to enhance neuroplasticity by inducing adult neurogenesis, synaptogenesis, angiogenesis and long-term potentiation (LTP) were developed and the results translated into clinical studies in schizophrenia...
June 2012: Current Pharmaceutical Biotechnology
Johannes Roth, Volker Hingst, Jan-Hendrik Lenz
PURPOSE: Severe trauma of the viscerocranium or neurocranium may result in impaired visual acuity or even blindness. Case based epidemiology, pathomechanism and actual strategies in midfacial trauma for initial therapy and prevention of posttraumatic blindness are discussed. CASE AND REVIEW: A 58-year old patient was treated at our Department of Oral and Maxillofacial Plastic Surgery after his central midface had been hit by a swinging steel girder. Initially he was blind on both eyes...
October 2012: Journal of Cranio-maxillo-facial Surgery
Enric Vilar, Ken Farrington
Residual renal function (RRF) is well recognized as an important marker of outcomes in peritoneal dialysis (PD), and contributes vitally to solute clearance. Recently, its importance in hemodialysis (HD) has emerged with evidence that it is strongly associated with improved outcomes. The presence of RRF is associated with improved nutrition, reduced erythropoetin requirements, better potassium clearance, and improved quality of life. Retrospective and observational evidence is now available, which suggests that the presence of RRF is independently associated with survival and that this benefit goes beyond what is expected simply from augmentation of small solute clearance...
September 2011: Seminars in Dialysis
Ivana Knezevic, Elwyn Griffiths
Biotechnology derived medicinal products are presently the best characterized biologicals with considerable production and clinical experience, and have revolutionized the treatment of some of the most difficult-to-treat diseases, prolonging and improving the quality of life and patient care. They are also currently one of the fastest growing segments of the pharmaceutical industry market. The critical challenge that the biopharmaceutical industry is facing is the expiry of patents for the first generation of biopharmaceuticals, mainly recombinant DNA derived products, such as interferons, growth hormone and erythropoetin...
September 2011: Biologicals: Journal of the International Association of Biological Standardization
Teguh Santoso, Cosphiadi Irawan, Idrus Alwi, Auda Aziz, Agus Kosasih, Sri Inggriani, Ardian Saputra, Merry Wintery, Linda Lison
AIM: to assess the safety and feasibility of combined granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO) based intracoronary peripheral blood stem cells (PBSCs) therapy in patients with recent myocardial infarction (RMI) who had successful reperfusion therapy with drug-eluting stent. METHODS: a total of 18 patients diagnosed with anterior ST-segment elevation AMI who had successful percutaneous coronary intervention (PCI) with drug-eluting stent implantation within 15 days after onset of symptom were enrolled...
April 2011: Acta Medica Indonesiana
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