Yuxiang Liang, Qizhi Shuai, Xiao Zhang, Shanshan Jin, Yuqian Guo, Zhaowei Yu, Xinrui Xu, Ruifang Ao, Zhiwei Peng, Huimin Lv, Sheng He, Chunfang Wang, Guohua Song, Zhizhen Liu, Hong Zhao, Qilong Feng, Ruochen Du, Bin Zheng, Zhaoyang Chen, Jun Xie
Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, in severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation and tumorigenicity limit its use. Exosomes, more stable and immunogenicity-reduced than parent cells, have emerged as a promising avenue for IUA treatment. In this study, a novel approach has been proposed wherein exosomes originating from decidual stromal cells are encapsulated within sodium alginate hydrogel (SAH) scaffolds to repair endometrial damage and restore fertility in a mouse IUA model...
February 5, 2024: Advanced Healthcare Materials