keyword
MENU ▼
Read by QxMD icon Read
search

Bacteria brain

keyword
https://www.readbyqxmd.com/read/29339415/genome-wide-identification-by-transposon-insertion-sequencing-of-escherichia-coli-k1-genes-essential-for-in-vitro-growth-gastrointestinal-colonizing-capacity-and-survival-in-serum
#1
Alex J McCarthy, Richard A Stabler, Peter W Taylor
Escherichia coli K1 strains are major causative agents of invasive disease of the new born. The age dependency of infection can be reproduced in the neonatal rat. Colonization of the small intestine following oral administration of K1 bacteria leads rapidly to invasion of the blood circulation; bacteria that avoid capture by the mesenteric lymphatic system and evade antibacterial mechanisms in the blood may disseminate to cause organ-specific infections such as meningitis. Some E. coli K1 surface constituents, in particular the polysialic acid capsule, are known to contribute to invasive potential but a comprehensive picture of the factors that determine the fully virulent phenotype has not so far emerged...
January 16, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29324833/evidence-for-pmat-and-oct-like-biogenic-amine-transporters-in-a-probiotic-strain-of-lactobacillus-implications-for-interkingdom-communication-within-the-microbiota-gut-brain-axis
#2
Mark Lyte, David R Brown
The ability of prokaryotic microbes to produce and respond to neurochemicals that are more often associated with eukaryotic systems is increasingly recognized through the concept of microbial endocrinology. Most studies have described the phenomena of neurochemical production by bacteria, but there remains an incomplete understanding of the mechanisms by which microbe- or host-derived neuroactive substances can be recognized by bacteria. Based on the evolutionary origins of eukaryotic solute carrier transporters, we hypothesized that bacteria may possess an analogous uptake function for neuroactive biogenic amines...
2018: PloS One
https://www.readbyqxmd.com/read/29317592/gut-microbiome-populations-are-associated-with-structure-specific-changes-in-white-matter-architecture
#3
Irene M Ong, Jose G Gonzalez, Sean J McIlwain, Emily A Sawin, Andrew J Schoen, Nagesh Adluru, Andrew L Alexander, John-Paul J Yu
Altered gut microbiome populations are associated with a broad range of neurodevelopmental disorders including autism spectrum disorder and mood disorders. In animal models, modulation of gut microbiome populations via dietary manipulation influences brain function and behavior and has been shown to ameliorate behavioral symptoms. With striking differences in microbiome-driven behavior, we explored whether these behavioral changes are also accompanied by corresponding changes in neural tissue microstructure...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29315980/probiotics-or-pro-healers-the-role-of-beneficial-bacteria-in-tissue-repair
#4
Jovanka Lukic, Vivien Chen, Ivana Strahinic, Jelena Begovic, Hadar Lev-Tov, Stephen C Davis, Marjana Tomic-Canic, Irena Pastar
Probiotics are beneficial microorganisms, known to exert numerous positive effects on human health, primarily in the battle against pathogens. Probiotics have been associated with improved healing of intestinal ulcers, and healing of infected cutaneous wounds. This manuscript reviews the latest findings on probiotics related to their pro-healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts and epithelial cells' migration and function...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29313865/evaluation-of-emdogain%C3%A2-antimicrobial-effectiveness-against-biofilms-containing-the-keystone-pathogen-porphyromonas-gingivalis
#5
Jérôme Lasserre, Selena Toma, Ana-Maria Dos Santos-Gonçalvez, Julian Leprince, Gaëtane Leloup, Michel Brecx
This study aimed to evaluate the antimicrobial activity of Emdogain® (EMD) against biofilms containing the periopathogen Porphyromonas gingivalis. A brain-Heart infusion broth inoculated with S. gordonii and P. gingivalis was perfused (7-d, anaerobiosis) through a closed circuit containing two Robbins devices as to form biofilms. The latter were then treated for 2 min with various antimicrobials (Chlorhexidine (CHX) 0.2%, Povidone iodine (PVI) 5%, PVI 10%, essential oils (EO), EO Zero™ or EMD)(n=8) and cell densities were calculated and compared...
January 9, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29302204/metagenome-analysis-of-bodily-microbiota-in-a-mouse-model-of-alzheimer-disease-using-bacteria-derived-membrane-vesicles-in-blood
#6
Jin-Young Park, Juli Choi, Yunjin Lee, Jung-Eun Lee, Eun-Hwa Lee, Hye-Jin Kwon, Jinho Yang, Bo-Ri Jeong, Yoon-Keun Kim, Pyung-Lim Han
Emerging evidence has suggested that the gut microbiota contribute to brain dysfunction, including pathological symptoms of Alzheimer disease (AD). Microbiota secrete membrane vesicles, also called extracellular vesicles (EVs), which contain bacterial genomic DNA fragments and other molecules and are distributed throughout the host body, including blood. In the present study, we investigated whether bacteria-derived EVs in blood are useful for metagenome analysis in an AD mouse model. Sequence readings of variable regions of 16S rRNA genes prepared from blood EVs in Tg-APP/PS1 mice allowed us to identify over 3,200 operational taxonomic units corresponding to gut microbiota reported in previous studies...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29301010/diminished-capsule-exacerbates-virulence-blood-brain-barrier-penetration-intracellular-persistence-and-antibiotic-evasion-of-hyperhemolytic-group-b-streptococcus
#7
Claire Gendrin, Sean Merillat, Jay Vornhagen, Michelle Coleman, Blair Armistead, Lisa Ngo, Anjali Aggarwal, Phoenicia Quach, Jacob Berrigan, Lakshmi Rajagopal
Group B Streptococcus (GBS) are encapsulated, β-hemolytic bacteria that are a common cause of infections in human newborns and certain adults. Two virulence factors important for GBS virulence are the sialic acid capsular polysaccharide that promotes immune evasion and the hemolytic pigment that induces host cell cytotoxcity. These virulence factors are often oppositely regulated by the CovR/CovS two-component system. Clinical GBS strains exhibiting hyperhemolysis and low capsule due to pathoadaptive covR/S mutations have been isolated from patients...
January 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29297142/bacterial-infections-of-the-central%C3%A2-nervous-system
#8
REVIEW
Renu Suthar, Naveen Sankhyan
Bacterial infections of the central nervous system (CNS) continue to be an important cause of morbidity and mortality in children. The spectrum of bacterial infection of CNS includes; focal or multifocal infections like brain abscesses or subdural empyema; or more generalized or diffuse infections like pyogenic meningitis or ventriculitis. Focal and generalized infections may co-exist in an individual patient. Prompt and adequate antibiotic therapy and occasionally neurosurgical interventions are the cornerstone of effective management...
January 3, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29290328/human-intestinal-microbiota-interaction-between-parasites-and-the-host-immune-response
#9
REVIEW
Oswaldo Partida-Rodríguez, Angélica Serrano-Vázquez, Miriam E Nieves-Ramírez, Patricia Moran, Liliana Rojas, Tobias Portillo, Enrique González, Eric Hernández, B Brett Finlay, Cecilia Ximenez
The human gut is a highly complex ecosystem with an extensive microbial community, and the influence of the intestinal microbiota reaches the entire host organism. For example, the microbiome regulates fat storage, stimulates or renews epithelial cells, and influences the development and maturation of the brain and the immune system. Intestinal microbes can protect against infection by pathogenic bacteria, viruses, fungi and parasites. Hence, the maintenance of homeostasis between the gut microbiota and the rest of the body is crucial for health, with dysbiosis affecting disease...
December 28, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29287686/indole-and-indoxyl-sulfate-gut-bacteria-metabolites-of-tryptophan-change-arterial-blood-pressure-via-peripheral-and-central-mechanisms-in-rats
#10
Tomasz Huć, Artur Nowinski, Adrian Drapala, Piotr Konopelski, Marcin Ufnal
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and indoxyl sulfate (indoxyl), a liver metabolite of indole.
December 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29283065/we-are-not-alone-in-our-body-insights-into-the-involvement-of-microbiota-in-the-etiopathogenesis-and-pharmacology-of-mental-illness
#11
Claudia Pisanu, Alessio Squassina
BACKGROUND: The etiopathogenesis of psychiatric disorders is still not completely understood. Growing evidence supports the hypothesis that mental illness and related disturbances in the brain neurobiology do not necessarily originate in the brain. Inflammation has been suggested to play a central role in psychiatric disorders, and altered levels of peripheral cytokines have been reported in several studies. OBJECTIVE AND METHODS: In this review, we present and discuss studies exploring the role of dysbiosis and products of the gut-microbiota in the pathogenesis of psychiatric disorders, as well as its potential involvement in mediating the effect of antidepressants, mood stabilizers, and antipsychotics...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29278751/correlation-between-gut-microbiota-and-personality-in-adults-a-cross-sectional-study
#12
Han-Na Kim, Yeojun Yun, Seungho Ryu, Yoosoo Chang, Min-Jung Kwon, Juhee Cho, Hocheol Shin, Hyung-Lae Kim
Personality affects fundamental behavior patterns and has been related with health outcomes and mental disorders. Recent evidence has emerged supporting a relationship between the microbiota and behavior, referred to as brain-gut relationships. Here, we first report correlations between personality traits and gut microbiota. This research was performed using the Revised NEO Personality Inventory and the sequencing data of the 16S rRNA gene in 672 adults. The diversity and the composition of the human gut microbiota exhibited significant difference when stratified by personality traits...
December 23, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29249963/exploring-the-association-between-alzheimer-s-disease-oral-health-microbial-endocrinology-and-nutrition
#13
REVIEW
Alice Harding, Ulrike Gonder, Sarita J Robinson, StJohn Crean, Sim K Singhrao
Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer's disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear. A working hypothesis links extrinsic inflammation as a secondary cause of AD. This hypothesis suggests a compromised oral hygiene leads to a dysbiotic oral microbiome whereby Porphyromonas gingivalis, a keystone periodontal pathogen, with its companion species, orchestrates immune subversion in the host...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29248954/methylmercury-biogeochemistry-in-freshwater-ecosystems-a-review-focusing-on-dom-and-photodemethylation
#14
REVIEW
Sara J Klapstein, Nelson J O'Driscoll
Mercury contamination is a growing concern for freshwater food webs in ecosystems without point sources of mercury. Methylmercury (MeHg) is of particular concern, as this is the form of mercury that crosses the blood-brain barrier and is neurotoxic to organisms. Wetlands and benthic sediments have high organic content and low oxygen availability. Anaerobic bacteria drive the metabolic function in these ecosystems and subsequently can methylate mercury. The bioavailability of MeHg is controlled by physicochemical characteristics such as pH, binding affinities, and dissolved organic matter (DOM)...
December 16, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29246601/infection-related-to-deep-brain-stimulation-in-patients-with-parkinson-disease-clinical-characteristics-and-risk-factors
#15
Mi Sun Kim, Jae Sim Jeong, Ho-Sung Ryu, Sang-Ho Choi, Sun Ju Chung
OBJECTIVE: Risk factors of infection after deep brain stimulation (DBS) surgery in patients with Parkinson disease (PD) have been controversial. We aimed to investigate the clinical characteristics and risk factors of infection after DBS surgery in PD patients. METHODS: We retrospectively investigated 246 consecutive DBS surgeries in 169 advanced PD patients. Clinical data were collected and analyzed to clarify the clinical characteristics associated with infection after DBS surgery...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29243233/finding-the-needle-in-the-haystack-systematic-identification-of-psychobiotics
#16
REVIEW
Aisling Bambury, Kiran Sandhu, John F Cryan, Timothy G Dinan
The brain-gut-microbiota axis is increasingly viewed as a novel paradigm in neuroscience with the capacity to generate innovative therapies for patients with psychiatric illnesses. Psychobiotics, defined as live bacteria which when ingested in adequate amounts confer mental health benefits, are increasingly of interest, as pre-clinical trials continue to show promising results. Particularly in stress related, anxiety and depressive disorders, there is potential for psychobiotics to deliver new therapies. The question of which microbes may prove to be the most promising psychobiotic in delivering such therapies at clinical level is of great importance...
December 15, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29241384/effects-of-ciprofloxacin-and-quercetin-on-fetal-brain-development-a-biochemical-and-histopathological-study
#17
Zumrut Dogan, Aymelek Cetin, Ebru Elibol, Nigar Vardi, Yusuf Turkoz
PURPOSE: Teratogens cause birth defects and malformations while human development is being completed. In pregnancy, urinary tract infection (UTI) is a common health problem caused by bacteria. The fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin, and gemifloxacin can treat various types of bacterial infections successfully. The aim of this study is to determine whether the use of ciprofloxacin during pregnancy causes oxidative stress on brain tissues of the fetus, and whether quercetin contributes to prevent this damage if stress has already occurred...
January 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29237453/human-microglia-and-astrocytes-constitutively-express-the-neurokinin-1-receptor-and-functionally-respond-to-substance-p
#18
Amanda R Burmeister, M Brittany Johnson, Vinita S Chauhan, Megan J Moerdyk-Schauwecker, Ada D Young, Ian D Cooley, Alejandra N Martinez, Geeta Ramesh, Mario T Philipp, Ian Marriott
BACKGROUND: The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, SP/NK-1R interactions have been associated with severe neuroinflammation and neuronal damage. We have previously demonstrated that NK-1R antagonists can limit neuroinflammatory damage in a mouse model of bacterial meningitis. Furthermore, we have since shown that these agents can attenuate bacteria-induced neuronal and glial inflammatory mediator production in nonhuman primate (NHP) brain explants and isolated neuronal cells, and following in vivo infection...
December 13, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29233677/alzheimer-s-disease-and-gut-microbiota-modifications-the-long-way-between-preclinical-studies-and-clinical-evidence
#19
REVIEW
Cesare Mancuso, Rosaria Santangelo
Recent studies have suggested the role of an infectious component in the pathogenesis of Alzheimer's disease (AD). In light of this, research has focused on some bacteria constituting the intestinal microbial flora which can produce amyloid. Once generated, the latter hypothetically triggers a systemic inflammatory response which compromises complex brain functions, such as learning and memory. Clinical studies have shown that, in cognitively impaired elderly patients with brain amyloidosis, there is lower abundance in the gut of E...
December 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29232157/bacterial-dissemination-to-the-brain-in-sepsis
#20
Benjamin H Singer, Robert P Dickson, Scott J Denstaedt, Michael W Newstead, Kwi Kim, Nicole R Falkowski, John R Erb-Downward, Thomas M Schmidt, Gary B Huffnagle, Theodore J Standiford
RATIONALE: Sepsis causes both brain dysfunction and neuroinflammation. It is unknown whether neuroinflammation in sepsis is initiated by dissemination of bacteria to the brain and sustained by persistent infection, or whether neuroinflammation is a sterile process resulting solely from circulating inflammatory mediators. OBJECTIVES: To determine if gut bacteria translocate to the brain during sepsis, and are associated with neuroinflammation. METHODS: Murine sepsis was induced using cecal ligation and puncture and sepsis survivor mice were compared to sham and unoperated controls...
December 12, 2017: American Journal of Respiratory and Critical Care Medicine
keyword
keyword
44816
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"