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https://www.readbyqxmd.com/read/28315901/the-effect-of-sitagliptin-on-lipid-metabolism-of-fatty-liver-mice-and-related-mechanisms
#1
Bilin Xu, Tian Shen, Lin Chen, Juan Xia, Cuiping Zhang, Hongping Wang, Ming Yu, Tao Lei
BACKGROUND In clinics, patients with type 2 diabetes complicated with non-alcoholic fatty liver disease (NAFLD) have been shown to receive significant improvements in blood glucose levels, lipid levels, and liver function after sitagliptin treatment, although the mechanism of drug action remains poorly understood. This study investigated the possible mechanism of sitagliptin on lipid metabolism of NAFLD mice. MATERIAL AND METHODS Male C57/BL6 mice were induced for NAFLD via 16 weeks of a high-fat diet, and were treated with 15 mg/kg/day sitagliptin for 16 consecutive weeks...
March 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28306532/evaluation-of-the-sub-chronic-toxicity-profile-of-the-corm-of-xanthosoma-sagittifolium-on-hematology-and-biochemistry-of-alloxan-induced-diabetic-wistar-rats
#2
Olayinka A Oridupa, Oluyemisi F Folasire, Adedotun J Owolabi
Background Hematological and biochemical changes associated with diabetes mellitus and probable reversal were assessed in alloxan-induced diabetic Wistar rats fed with varied percentages of Xanthosoma sagittifolium corm feed (Xs). The changes were compared to normoglycemic rats and diabetic rats treated with glibenclamide. Methods The study had eight groups in all with group 8 (control) consisting of five normoglycemic rats fed with normal rat pellets (Nrp). Diabetes was experimentally induced by intraperitoneal injection of alloxan to normoglycemic rats...
March 11, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28304335/the-relationship-between-fatty-acids-and-different-depression-related-brain-regions-and-their-potential-role-as-biomarkers-of-response-to-antidepressants
#3
REVIEW
Maria Fernanda Fernandes, David M Mutch, Francesco Leri
Depression is a complex disorder influenced by a variety of biological and environmental factors. Due to significant heterogeneity, there are remarkable differences in how patients respond to treatment. A primary objective of psychiatric research is to identify biological markers that could be used to better predict and enhance responses to antidepressant treatments. Diet impacts various aspects of health, including depression. The fatty acid composition of the Western diet, which has a high ratio of n-6:n-3 polyunsaturated fatty acids, is associated with increased incidence of depression...
March 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28302517/exercise-training-rescues-high-fat-diet-induced-neuronal-nitric-oxide-synthase-expression-in-the-hippocampus-and-cerebral-cortex-of-mice
#4
Yuki Tomiga, Saki Yoshimura, Ai Ito, Shihoko Nakashima, Kentaro Kawanaka, Yoshinari Uehara, Hiroaki Tanaka, Yasuki Higaki
Consumption of a high fat diet (HFD) and being overweight both induce functional deterioration and atrophy of the hippocampus. These alterations are associated with mental disorders such as depression and anxiety. Exercise combats obesity and enhances brain health. There is substantial evidence that neuronal nitric oxide synthase (nNOS) is a key regulator of affective behavior, and that increased brain nNOS leads to anxiety while environmental enrichment (EE), which reduces brain nNOS, has anxiolytic effects...
March 13, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28302152/myocardial-susceptibility-to-ischaemia-reperfusion-in-obesity-a-re-evaluation-of-the-effects-of-age
#5
I Webster, R Salie, E Marais, W-J Fan, G Maarman, B Huisamen, A Lochner
BACKGROUND: Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and diet-induced obesity (DIO) on myocardial I/R injury and preconditioning potential. METHODS: Four groups of Wistar male rats were used: age-matched controls (AMC) receiving standard rat chow for (i) 16 weeks and (ii) 16 months respectively; DIO rats receiving a sucrose-supplemented diet for (iii) 16 weeks and (iv) 16 months respectively...
March 17, 2017: BMC Physiology
https://www.readbyqxmd.com/read/28298322/fruit-and-vegetable-consumption-and-psychological-distress-cross-sectional-and-longitudinal-analyses-based-on-a-large-australian-sample
#6
Binh Nguyen, Ding Ding, Seema Mihrshahi
OBJECTIVES: Growing evidence suggests a link between diet and mental health. This study aimed to investigate the association between fruit and vegetable consumption and the prevalence and incidence of psychological distress in middle-aged and older Australians. DESIGN: Cross-sectional and prospective. SETTING: New South Wales, Australia. METHODS: A sample of 60 404 adults aged ≥45 years completed baseline (2006-2008) and follow-up (2010) questionnaires...
March 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28295744/contributing-factors-for-therapeutic-diet-adherence-in-patients-receiving-haemodialysis-treatment-an-integrative-review
#7
REVIEW
Lissete González Oquendo, José Miguel Morales Asencio, Candela Bonill de Las Nieves
AIMS AND OBJECTIVES: The objective of this integrative review is to identify the factors that contribute to diet adherence in people suffering from kidney disease who are receiving haemodialysis treatment. BACKGROUND: Adherence to the therapeutic regimen determines therapeutic success, quality of life, and survival in patients on haemodialysis. Lack of diet adherence ranges from 25 to 86% in patients receiving haemodialysis treatment and affects patient morbidity and mortality...
March 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28294985/effects-of-a-diet-based-weight-reducing-program-with-probiotic-supplementation-on-satiety-efficiency-eating-behaviour-traits-and-psychosocial-behaviours-in-obese-individuals
#8
Marina Sanchez, Christian Darimont, Shirin Panahi, Vicky Drapeau, André Marette, Valerie H Taylor, Jean Doré, Angelo Tremblay
This study evaluated the impact of probiotic supplementation (Lactobacillus rhamnosus CGMCC1.3724 (LPR)) on appetite sensations and eating behaviors in the context of a weight-reducing program. Obese men (n = 45) and women (n = 60) participated in a double-blind, randomized, placebo-controlled trial that included a 12-week weight loss period (Phase 1) based on moderate energy restriction, followed by 12 weeks of weight maintenance (Phase 2). During the two phases of the program, each subject consumed two capsules per day of either a placebo or a LPR formulation (10 mg of LPR equivalent to 1...
March 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28290485/complementary-transcriptomic-and-proteomic-analyses-reveal-regulatory-mechanisms-of-milk-protein-production-in-dairy-cows-consuming-different-forages
#9
Wenting Dai, Qiong Chen, Quanjuan Wang, Robin R White, Jianxin Liu, Hongyun Liu
Forage plays a critical role in the milk production of dairy cows; however, the mechanisms regulating bovine milk synthesis in dairy cows fed high forage rations with different basal forage types are not well-understood. In the study, rice straw (RS, low-quality) and alfalfa hay (AH, high-quality) diets were fed to lactating cows to explore how forage quality affected the molecular mechanisms regulating milk production using RNA-seq transcriptomic method with iTRAQ proteomic technique. A total of 554 transcripts (423 increased and 131 decreased) and 517 proteins (231 up-regulated and 286 down-regulated) were differentially expressed in the mammary glands of the two groups...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28283824/prospective-association-between-adherence-to-the-mediterranean-diet-and-risk-of-depressive-symptoms-in-the-french-su-vi-max-cohort
#10
Moufidath Adjibade, Karen E Assmann, Valentina A Andreeva, Cédric Lemogne, Serge Hercberg, Pilar Galan, Emmanuelle Kesse-Guyot
PURPOSE: This study examines whether adherence to the Mediterranean Diet (MD) measured by several dietary indexes was associated with incident depressive symptoms in a large French cohort. METHODS: The study sample consisted of 3523 participants from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort who had at least three dietary records at baseline during the first 2 years of follow-up (1994-1996), free of depression at the beginning of the study (1996-1997) and available Center for Epidemiologic Studies Depression Scale (CES-D) data at the end of follow-up (2007-2009)...
March 10, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28282940/the-health-and-working-conditions-of-women-employed-in-child-care
#11
Laura Linnan, Gabriela Arandia, Lori A Bateman, Amber Vaughn, Natalie Smith, Dianne Ward
Over one million women are employed in child care and are among the lowest wage workers in the US. The health and working conditions of 674 child care workers (118 administrators and 556 staff) from 74 centers is described using baseline data from a larger intervention trial. Participants were 39.9 (±13.0) years old; 55.4% African American, 37.1% Caucasian, and 5.3% of Hispanic ethnicity. Seventy-six percent reported having an Associate's degree or less; 42% were classified as at or below poverty (<$20,000); and exhibited many health risks such as excess weight, insufficient activity, poor diet, and inadequate sleep...
March 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28279226/the-ppar-pan-agonist-bezafibrate-ameliorates-cardiomyopathy-in-a-mouse-model-of-barth-syndrome
#12
Yan Huang, Corey Powers, Victoria Moore, Caitlin Schafer, Mindong Ren, Colin K L Phoon, Jeanne F James, Alexander V Glukhov, Sabzali Javadov, Frédéric M Vaz, John L Jefferies, Arnold W Strauss, Zaza Khuchua
BACKGROUND: The PGC-1α/PPAR axis has been proposed as a potential therapeutic target for several metabolic disorders. The aim was to evaluate the efficacy of the pan-PPAR agonist, bezafibrate, in tafazzin knockdown mice (TazKD), a mouse model of Barth syndrome that exhibits age-dependent dilated cardiomyopathy with left ventricular (LV) dysfunction. RESULTS: The effect of bezafibrate on cardiac function was evaluated by echocardiography in TazKD mice with or without beta-adrenergic stress...
March 9, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28273871/the-association-between-dietary-quality-and-dietary-guideline-adherence-with-mental-health-outcomes-in-adults-a-cross-sectional-analysis
#13
Amy P Meegan, Ivan J Perry, Catherine M Phillips
The prevalence of adverse mental health outcomes in adults is increasing. Although beneficial effects of selected micronutrients and foods on mental health have been reported, they do not reflect the impact of the habitual diet on mental health. Therefore, our objective is to examine potential associations between dietary quality, dietary composition and compliance with food pyramid recommendations with depressive symptoms, anxiety and well-being (assessed using CES-D, HADS-A and WHO-5 screening tools) in a cross-sectional sample of 2047 middle-aged adults...
March 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28273202/lifestyle-intervention-using-the-psychoeducational-approach-is-associated-with-greater-cardiometabolic-benefits-and-retention-of-individuals-with-worse-health-status
#14
Adriana Cezaretto, Camila Risso de Barros, Bianca de Almeida-Pititto, Antonela Siqueira-Catania, Milena Monfort-Pires, Luciana Gavilan Dias Folchetti, Sandra Roberta Gouvea Ferreira
Objective: This study aimed to compare the effects of two lifestyle intervention programs for type 2 diabetes mellitus (T2DM) prevention - traditional or interdisciplinary psychoeducation-based intervention - in daily habits and cardiometabolic risk factors and investigate the role of the psychoeducational approach for the retention of individuals in the program. Subjects and methods: Between 2008 and 2010, in a public health service, 183 pre-diabetic individuals were allocated to two 18-month interventions involving diet and physical activity...
January 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28262343/pedf-improves-atherosclerotic-plaque-stability-by-inhibiting-macrophage-inflammation-response
#15
Hao Wen, Minghao Liu, Zhaoqiang Liu, Xiaoyan Yang, Xiaoling Liu, Mei Ni, Mei Dong, Xiaorong Luan, Yan Yuan, Xinsheng Xu, Huixia Lu
BACKGROUND: Atherosclerosis is a vascular disease with plaque formation and growth. Instable plaque with chronic inflammation is closely related to adverse cardiac outcomes. Pigment epithelium-derived factor (PEDF) is an endogenous multifunctional cytokine that possesses the ability of anti-inflammation. The aim of this study is to detect whether PEDF has protective effect on the stability of atherosclerotic plaque and to explore whether the effect of anti-inflammation involved. METHODS AND RESULTS: ApoE(-/-) mice fed with high fat diet and RAW264...
February 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28259401/replacing-alfalfa-silage-with-tannin-containing-birdsfoot-trefoil-silage-in-total-mixed-rations-for-lactating-dairy-cows
#16
G A Broderick, J H Grabber, R E Muck, U C Hymes-Fecht
Two lactation trials were conducted comparing the feeding value of silages made from birdsfoot trefoil (BFT, Lotus corniculatus L.) that had been selected for low (BFTL), medium (BFTM), and high (BFTH) levels of condensed tannins (CT) to an alfalfa silage (AS) when fed as the principal forage in total mixed rations. Diets also included corn silage, high-moisture shelled corn, soybean meal, soy hulls, and supplemental fat. In trial 1, 32 lactating Holstein cows were blocked by days in milk, assigned to treatment sequences in 8 balanced 4 × 4 Latin squares, and fed 50% dietary dry matter from AS or 1 of 3 BFT silages containing 0...
March 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28259042/probiotic-treatment-reduces-depressive-like-behaviour-in-rats-independently-of-diet
#17
Anders Abildgaard, Betina Elfving, Marianne Hokland, Gregers Wegener, Sten Lund
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive disorder (MDD). However, some conceptual and mechanistical aspects need further elucidation. We therefore aimed at investigating whether the habitual diet may interact with the effect of probiotics on depression-related behaviour and further examined some potentially involved mechanisms underlying the microbe-mediated behavioural effects...
February 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28258037/the-role-of-zinc-deficiency-induced-changes-in-the-phospholipid-protein-balance-of-blood-serum-in-animal-depression-model-by-raman-ftir-and-uv-vis-spectroscopy
#18
J Depciuch, M Sowa-Kućma, G Nowak, B Szewczyk, U Doboszewska, M Parlinska-Wojtan
Depression is a serious mental illness. To study the mechanisms of diseases and search for new, more effective therapies, animal models are used. Unfortunately, none of the available models does reflect all symptoms of depression. Zinc deficiency is proposed as a new animal model of depression. However, it has not been yet validated in a detailed manner. Recently, spectroscopic techniques are increasingly being used both in clinical and preclinical studies. Here we examined the effect of zinc deficiency and amitryptyline treatment on the phospholipid - protein balance in the blood serum of rats using Raman, Fourier Transform Infra Red (FTIR) and UV-vis technique...
February 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28255098/outcomes-of-an-integrated-community-based-nurse-led-cardiovascular-disease-prevention-programme
#19
S B Connolly, K Kotseva, C Jennings, A Atrey, J Jones, A Brown, P Bassett, D A Wood
BACKGROUND: National guidance for England recommends that cardiovascular disease (CVD) should be managed as a family of diseases in the community. Here, we describe the results of such an approach. METHODS: Patients with established CVD or who were at high multifactorial risk (HRI) underwent a 12-week community-based nurse-led prevention programme (MyAction) that included lifestyle and risk factor management, prescription of medication and weekly exercise and education sessions...
March 2, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28254388/measuring-unmet-needs-for-anticipatory-guidance-among-adolescents-at-school-based-health-centers
#20
Mary M Ramos, Rachel A Sebastian, Scott P Stumbo, Jane McGrath, Gerry Fairbrother
PURPOSE: Our previously validated Youth Engagement with Health Services survey measures adolescent health care quality. The survey response format allows adolescents to indicate whether their needs for anticipatory guidance were met. Here, we describe the unmet needs for anticipatory guidance reported by adolescents and identify adolescent characteristics related to unmet needs for guidance. METHODS: We administered the survey in 2013-2014 to 540 adolescents who used school-based health centers in Colorado and New Mexico...
February 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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